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10,007,302 | The activity of 4CMB in the BHK cell-transformation assay. | [
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10,007,303 | A comparison of the response of BHK21 C13 cells to 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl and benzyl chloride in a cell transformation test. | [
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10,007,304 | Enhancement of viral transformation of hamster embryo cells by pretreatment with 4-chloromethylbiphenyl. | [
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10,007,305 | Treatment of Syrian hamster embryo cells with 4-chloromethylbiphenyl produced reproducible and quantitative concentration-dependent enhancement of viral transformation the statistical significance of which was independent of cell lethality. These results suggest this compound has carcinogenic potential since positive r... | [
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10,007,306 | The cytotoxic and mutagenic effects of 4CMB, BC and 4HMB in V79 Chinese hamster cells. | [
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10,007,307 | Mutation at the TK locus of mouse lymphoma L5178Y cells by 4CMB, 4HMB and BC. | [
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10,007,308 | Cytotoxic, and mutagenic effects at the HGPRT locus of 4CMB in V79 Chinese hamster cells. | [
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10,007,309 | The induction of mutants in L5178Y mouse lymphoma cells by 4-chloromethylbiphenyl. | [
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10,007,310 | The use of cultured mammalian cells the UKEMS collaborative genotoxicity trial (1981). | [
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10,007,311 | The effects of 4CMB, 4HMB and BC on SCE, chromosome aberration and point mutation in cultured Chinese hamster ovary cells. | [
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10,007,312 | Cultured Chinese hamster ovary cells (CHO-KI-BH4) were treated for 2 h with 4CMB, 4HMB and BC, in the absence of any exogenous metabolic activation system. The cells were subjected to tests for survival, sister-chromatid exchange, chromosome aberration and mutation to thioguanine resistance. 4HMB had no effect in any t... | [
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10,007,313 | Studies with 4-chloromethylbiphenyl in P388 cells selected in 5-iodo-2'-deoxyuridine. | [
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10,007,314 | Investigation of the cytogenetic effects of 4-chloromethylbiphenyl (4CMB) on cultured rat-liver cells. | [
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10,007,315 | Investigation of the cytogenetic effects of BC and 4CMB on human peripheral lymphocytes in vitro. | [
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10,007,316 | An assessment of the clastogenic potential of 4-chloromethylbiphenyl in human lymphocytes in vitro. | [
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10,007,317 | The clastogenic potential of 4CMB was assessed in vitro in human lymphocytes from 4 donors (2 male and 2 female) both with and without auxiliary metabolic activation. Although there were some variation in the response of the cells from different donors to 4CMB using 2 criteria for interpretation of the results; it was ... | [
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10,007,318 | Metaphase analysis of human lymphocytes treated with 4-chloromethylbiphenyl and benzyl chloride. | [
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10,007,319 | 4CMB and BC caused mitotic inhibition in human lymphocytes at low doses (greater than 20 and greater than 10 microgram/ml respectively). At non-inhibitory concentrations, neither substance produced increases in cells with breaks or breaks per cell, although 4CMB did induce a significant increase in gaps at dose. 4CMB a... | [
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10,007,320 | Sister-chromatid exchanges in human lymphocytes treated with 4-chloromethylbiphenyl and benzyl chloride. | [
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10,007,321 | At non-inhibitory concentrations, 4CMB and BC both induced small, but dose-related increases in SCE. The dose-response curves gave a highly significant correlation for 4CMB (r = 0.996, P less than 0.001) and a significant correlation for BC (r = 0.757, P less than 0.05) which reflects the relative activities of these s... | [
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10,007,322 | Chromosome analysis of cultured rat-liver epithelial cells (RL4) treated with 4-chloromethylbiphenyl, 4-hydroxymethylbiphenyl and benzyl chloride. | [
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10,007,323 | UKEMS collaborative genotoxicity trial. Cytogenetic tests of 4CMB, BC and 4HMB: summary and appraisal. | [
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10,007,324 | Sperm head abnormality test. | [
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10,007,325 | The effect of 4CMB on germ cells of the mouse. | [
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10,007,326 | The effect of 4CMB on meiosis in the mouse was studied using both male and female test systems. Females were superovulated and treated with 4CMB at metaphase I and oocytes sampled at metaphase II. Similarly with males, chromosome analysis was made at metaphase II for spermatocytes treated at metaphase I. No increase in... | [
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10,007,327 | 4-Chloromethylbiphenyl (4CMB)--an in vivo cytogenetic study in the Chinese hamster (Cricetulus griseus). | [
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10,007,328 | The study was part of the UK EMS Genetic Toxicology trial, to determine the clastogenic potential of 4CMB in the bone-marrow cell chromosomes of the Chinese hamster. At dose levels of 50, 100, 200, 300 and 400 mg/kg of 4CMB statistical analysis of the data failed to show any significant differences in chromosomal damag... | [
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10,007,329 | The assay of 4-chloromethylbiphenyl in the dominant lethal assay in mice. | [
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10,007,330 | 4CMB, 4HMB and BC evaluated by the micronucleus test using a multiple sampling method. | [
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10,007,331 | Assay of 4CMB, 4HMB and BC by the micronucleus tests--subcutaneous administration. | [
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10,007,332 | Dose-response relationship for induction of structural chromosome aberrations in Chinese hamster oocytes after x-irradiation. | [
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10,007,333 | Cytogenetic effects of BC and 4CMB in the mouse evaluated by the micronucleus test. | [
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10,007,334 | The effects of 4CMB, 4HMB and BC in the micronucleus test. | [
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10,007,335 | An evaluation of the mutagenic potential of 4-chloromethylbiphenyl (4CMB) using the micronucleus test. | [
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10,007,336 | 4CMB: investigation of activity in a mouse micronucleus test. | [
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10,007,337 | To study possible clastogenic effects of 4-chloromethylbiphenyl (4CMB), a mouse micronucleus test was performed (as part of the UKEMS genetic toxicology trial). Mice were given 4CMB by intraperitoneal injection, once daily for 5 consecutive days. Although the range of dosages employed included highly toxic or lethal do... | [
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10,007,338 | UKEMS genotoxicity trial 1981. In vivo assay systems. | [
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10,007,339 | 4CMB was tested in 7 mouse micronucleus assays (3 i.p., 2 oral, 1 s.c., 1 foetal), 2 mouse sperm-head morphology assays (1 i.p., 1 s.c.), 1 dominant lethal test in mouse (oral), 3 SLRL tests in Drosophila (2 feeding, 1 injection) and one somatic cell segregation assay in Drosophila (feeding). 4HMB was tested in 4 mouse... | [
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0.0... |
10,007,340 | Genetic effects of microwave radiation in mice. | [
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10,007,341 | Effects in the mammalian spot test: cyclamate versus saccharin. | [
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10,007,342 | Activity of 4CMB in the mouse-skin sebaceous-gland suppression test. | [
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0.0386... |
10,007,343 | Is 4CMB clastogenic in vivo? Preliminary results from the mouse transplacental micronucleus test. | [
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10,007,344 | Saccharin and the induction of presumed somatic mutations in the mouse. | [
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0.0217... |
10,007,345 | Cytotoxicity and mutagenicity of dinitrotoluenes in Chinese hamster ovary cells. | [
0.02567928656935692,
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10,007,346 | Technical grade dinitrotoluene (DNT), a mixture composed predominantly of 2,4- and 2,6-DNT but containing lesser amounts of 2,3-, 2,5-, 3,4- and 3,5-DNT, has been shown to be a hepatocarcinogen in rats, The mutagenicity of these compounds has been evaluated using the CHO/HGPRT system, a quantitative mammalian somatic c... | [
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10,007,347 | A novel mutant of mouse lymphoma cells sensitive to alkylating agents and caffeine. | [
-0.011780812405049801,
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... |
10,007,348 | Two-methyl-methanesulfonate-sensitive strains have been isolated, one of which, M10, was cross-sensitive to X-rays as reported before. Sensitivities of parental L5178Y, M10, and newly isolated MS-1 cells to various mutagens were examined. Mutagens tested were UV, X-rays, 4-nitroquinoline 1-oxide (4NQO), caffeine and al... | [
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0.0355426... |
10,007,349 | Cytogenetic study of workers exposed to methyl-parathion. | [
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0.04911928... |
10,007,350 | When compared with non-exposed controls, a group of pesticide plant workers chronically exposed to methyl-parathion did not show an increased frequency of chromosome aberrations in lymphocyte cultures. Although methyl-parathion increased chromosome aberrations in cases of intoxication, a chronic exposure to small doses... | [
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0.014004687778651714,
0.0412961... |
10,007,351 | Patulin, a further clastogenic mycotoxin, is negative in the SCE assay in Chinese hamster V79-E cells in vitro. | [
0.0406433567404747,
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0.009677276946604252,
0.0... |
10,007,352 | Patulin is a potent inducer of chromatid-type aberrations in Chinese hamster V79-E cells, but loses its activity when 9000 g supernatant of rat-liver homogenate is added. The narrow dose range of patulin clastogenicity shows a quantitative relationship between absolute amount of mycotoxin applied and the number of indi... | [
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0... |
10,007,353 | Action of mutagens at germ-cell stages. | [
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0.003738375147804618,
0.03470... |
10,007,354 | 2,4-Dichlorophenoxyacetic acid--a new environmental mutagen. | [
-0.01840018481016159,
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0.025877470150589943,
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0.028444016352295876,
-0.... |
10,007,355 | Induction of sister-chromatid exchange in human lymphocytes by smoke condensates from different brands of cigarette. | [
-0.013060477562248707,
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0.006282326299697161,
... |
10,007,356 | Normal sister-chromatid exchanges in oral contraceptive users. | [
-0.03748677670955658,
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0.02437858283519745,
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-0.05820141... |
10,007,357 | Sister-chromatid exchanges in peripheral lymphocytes were examined in 115 healthy women, aged 15-43 years. 63 women were on no medication at all, and 52 women used oral contraceptives. 30 metaphases from each culture were scored for SCE. In accord with previous studies, cigarette smoking increased SCE. The use of oral ... | [
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0.030294593423604965,
-0.0905030... |
10,007,358 | 5-Bromodeoxyuridine substitution and differential radiosensitivity of uni- and bi-filar chromatids. | [
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0.06454455107450485,
0.0... |
10,007,359 | Radiosensitivity of fibroblasts from patients with retinoblastoma and chromosome-13 anomalies. | [
-0.0014568092301487923,
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0.0... |
10,007,360 | Diploid fibroblast cell strains derived from 14 patients with various forms of retinoblastoma (RB) and 5 non-RB patients with constitutional chromosome anomalies involving chromosome 13 were assayed for their clonogenic survival after X-irradiation. Cells from a patient with ataxia telangiectasia (AT) was used as a rad... | [
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0.04217235743999481,
0.023786716163158417,
0.030665788799524307,
0... |
10,007,361 | Cytogenetic analyses of lymphocytes from workers in a nickel refinery. | [
-0.033492278307676315,
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0.052273716777563095,
0.0... |
10,007,362 | Comparison of the frequencies of SCEs induced by chemical mutagens in bone-marrow, spleen and spermatogonial cells of mice. | [
-0.013670231215655804,
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0.01903289556503296,
0.00469... |
10,007,363 | Chromosome-breaking ability of arecoline, a major betel-nut alkaloid, in mouse bone-marrow cells in vivo. | [
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-0.0... |
10,007,364 | The chromosomal damaging properties of arecoline, a major betel-nut alkaloid were investigated in vivo after its administration to mice. Arecoline was injected in doses of 0.25, 0.5, 1 and 2 mg for 10, 20 and 30 days each. Significant numbers of aberrations were observed in the form of chromatid breaks, chromosome brea... | [
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-0.03... |
10,007,365 | The killifish Nothobranchius rachowi, a new animal in genetic toxicology. | [
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0.0078383... |
10,007,366 | Nothobranchius rachowi, a tropical fish that belongs to the family of the Cyprinodontidae, is introduced as a new animal for genetic toxicological studies. The karyotype of N. rachowi consists of 16 large chromosomes. This species can be used for studies on chromosomal aberrations as well as for observations on sister-... | [
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0.014171849936246872,
0.040... |
10,007,367 | Mutagenic evaluation of carcinogens and non-carcinogens in the L5178Y/TK assay utilizing postmitochondrial fractions (S9) from normal rat liver. | [
0.06837303936481476,
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-0.... |
10,007,368 | As part of continuing effort to investigate various metabolic activation procedures in the L5178Y TK +/- leads to TK -/- mutation assay, a series of 18 chemicals including both carcinogens and non-carcinogens selected from 7 chemical classes were tested in the presence of 5% (v/v) 9000 x g postmitochondrial supernatant... | [
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0.012693580240011215,
-0.... |
10,007,369 | Mutagenicity testing on non-selectively cloned Chinese hamster ovary cells with the protein-mapping method. | [
0.006304779089987278,
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0.05571013316512108,
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0.03854008764028549,
0.01815163902938366,
-0.0055555314756929874,
-0.066101... |
10,007,370 | Chemical mutagenesis was studied on Chinese hamster ovary cells by protein mapping. Cell cultures were treated with methylnitrosourea and the cells were cloned in non-selective media. The proteins of single clones were separated by 2-dimensional electrophoresis and analysed for qualitative (electrophoretic mobility) an... | [
0.02876066416501999,
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0.06807157397270203,
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0.005842429585754871,
-0.0825164... |
10,007,371 | Creatine kinase activity in normal and Duchenne muscular dystrophy fibroblasts. | [
-0.059207916259765625,
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0.012852109968662262... |
10,007,372 | Cultured human skin fibroblasts from 9 patients with Duchenne muscular dystrophy (DMD) and 8 normal age- and sex-matched controls were examined for creatine kinase (CK) activity. Both the normal and the DMD fibroblasts were found to have significant levels of CK activity (approximately 10 x 10(-3) IU per milligram of f... | [
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... |
10,007,373 | Hereditary polymyopathy and cardiomyopathy in the Syrian hamster. I. Progression of heart and skeletal muscle lesions in the UM-X7.1 line. | [
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0.04116617515683174,
0.01303738821297884,
0.02... |
10,007,374 | The Syrian hamster polymyopathy is a hereditary disease, transmitted by an autosomal recessive gene, involving the heart and the entire musculature. The chronology of the pathologic events in the myocardium and skeletal muscle has been investigated in UM-X7.1 myopathic hamsters aged 0-250 days. A phasic pattern in the ... | [
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0.04563470929861069,
0.0691... |
10,007,375 | Hereditary polymyopathy and cardiomyopathy in the Syrian hamster. II. Development of heart necrotic changes in relation to defective mitochondrial function. | [
0.049515772610902786,
0.02263857051730156,
0.0282415933907032,
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0.029447542503476143,
0... |
10,007,376 | The mitochondrial oxidative phosphorylation, calcium and magnesium contents, and swelling-contraction activity were investigated in relation to the progression of the hereditary hamster cardiomyopathy. The assessment was made in animals between 22 and 232 days of age, which were divided into 7 groups according to stage... | [
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0.01485175359994173,
0.004041461274027824,
0.0051872581243515015,
0.09557267278432846,
0.048... |
10,007,377 | Changes in the forms of the components of the troponin complex during regeneration of injured skeletal muscle. | [
-0.08789778500795364,
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0.023234475404024124,
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... |
10,007,378 | Using the immunoperoxidase technique, antibodies to the fast components of the troponin complex stained all regenerating cells after localized alcohol injury to rat skeletal muscle. Antibodies to slow troponin components stained only some of these cells. About 6 weeks after injury with the nerve intact, the fast and sl... | [
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0.020373880863189697,
0.07003600150346756,
0.044979967176914215,
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... |
10,007,379 | Gangliosides and sialoglycoproteins in normal and denervated rat diaphragm muscle. | [
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0.016521846875548363,
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0.0... |
10,007,380 | Ganglioside-and glycoprotein-bound sialic acid in endplate and non-endplate regions of rat diaphragm muscles were assessed 1-16 days after phrenic nerve transection. Sialic acid in glycoproteins (90% of total) and gangliosides (10% of total) from intact hemidiaphragms was distributed uniformly throughout endplate and n... | [
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0.03608953580260277,
0.08017207682132721,
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0.0506... |
10,007,381 | Neuron specific in vitro cytotoxicity of sera from patients with amyotrophic lateral sclerosis. | [
0.009281597100198269,
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0.028718607500195503,
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0.1214248389005661,
0.07511410117149353,
0.0099... |
10,007,382 | Sera from patients with amyotrophic lateral sclerosis (ALS) were assayed for a neuron-specific cytotoxic effect on long-term organized cultures of neonatal mouse anterior horn segments. Blind studies show that ALS sera when incorporated into the culture media have a greater degree of antineuronal toxicity than sera fro... | [
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0.045974086970090866,
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0.051128752529621124,
0.015408358536660671,
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10,007,383 | Regeneration of peripheral nerve through a polyglactin tube. | [
-0.016426915302872658,
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0.009588929824531078,
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0.10758396983146667,
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0.0... |
10,007,384 | Polyglactin 910, a resorbable synthetic material, was used as a mesh-tube to bridge defects (7 to 9 mm in length) in a sectioned rabbit tibial nerve. After absorption of the mesh a new nerve sheath was formed which enclosed numerous minute fascicles of regenerating axons. The polyglactin tube influenced the direction t... | [
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0.0937558189034462,
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0.08897947520017624,
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0.1707324... |
10,007,385 | Serum creatine kinase in the detection of Duchenne muscular dystrophy carriers: effects of season and multiple testing. | [
-0.05036987364292145,
0.01022128015756607,
0.01075124554336071,
0.008739864453673363,
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0.062396980822086334,
0.0895... |
10,007,386 | The usefulness of serum creatine kinase (CK) activity in the detection of Duchenne muscular dystrophy (DMD) carriers is dependent upon a reliable control distribution. In controls there is a small but reproducible seasonal variation in CK activity, with a statistically significant variation in the upper 95th percentile... | [
-0.02133280038833618,
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0.007124017924070358,
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0.... |
10,007,387 | Lupus myositis. | [
-0.03885187208652496,
0.02748866379261017,
0.037944894284009933,
0.04777360334992409,
0.027505477890372276,
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0.01217346079647541,
0.011037194170057774,
0.03219250962138176,
0.018808022141456604,
0.0532740019... |
10,007,388 | Eleven patients met rigid criteria for having both polymyositis and systemic lupus erythematosus (SLE). The patients differed little in clinical features when compared with patients who had SLE and polymyositis in a previously reported series. The overall mortality rate of 18% and the finding that 56% of survivors were... | [
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0.002106644678860903,
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0.09948188811540604,
0.0536128394305706,
0.0341... |
10,007,389 | Energetics of isometric contraction in dystrophic fast and slow muscles. | [
-0.020372234284877777,
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0.028740448877215385,
0.027728023007512093,
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0.0037009394727647305,
0.... |
10,007,390 | The amount of phosphoryl creatine (PC) hydrolysed during a ten-second isometric contraction was measured in the biceps brachii (fast) and soleus (slow) muscles of adult normal and dystrophic mice (Re 129 strain) following inhibition of glycolysis and oxidative phosphorylation. The dystrophic muscles were found to have ... | [
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0.019414624199271202,
0.029241658747196198,
0.006588229909539223,
0... |
10,007,391 | A preparation for studying dystrophic avian muscle and neuromuscular junctions. | [
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0.0002487479359842837,
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0.03792053461074829,
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0.001085606636479497,
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0.09... |
10,007,392 | The extensor of the second digit of the chicken wing (EDII) is a small, fast-twitch muscle susceptible to chicken muscular dystrophy and well suited for correlated studies of the morphology and physiology of identified nerve and muscle fibers. In cross section, the dystrophic EDII shows morphological abnormalities comm... | [
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0.03573586046695709,
0.01545854564756155,
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0.07... |
10,007,393 | The effects of diltiazem in dystrophic hamsters. | [
0.11776749789714813,
0.0439922958612442,
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0.03455787152051926,
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0.021820437163114548,
0.029204921796917915,
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0.0890412... |
10,007,394 | Calcium accumulates in muscles of dystrophic hamsters (DH) and patients with Duchenne muscular dystrophy. Various Ca antagonists were beneficial to the cardiomyopathy of DH, but had only minor effects on skeletal muscle. We administered a new Ca antagonist, diltiazem, 25 mg/kg/day orally to normal and dystrophic hamste... | [
0.02993806079030037,
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0.0407143272459507,
0.0038901299703866243,
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0.033278755843639374,
0.1114809... |
10,007,395 | Increased protein degradation in muscle diseases: cause or effect. | [
0.018509667366743088,
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0.027600964531302452,
0.04776489734649658,
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0.11552365869283676,
0.05017828941345215,
0.04... |
10,007,396 | "Idiopathic" Bence Jones proteinuria: long-term follow-up in seven patients. | [
-0.027993401512503624,
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0.006335048470646143,
0.025378430262207985,
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0.0015244997339323163,
0.00743979774415493,
0.064... |
10,007,397 | We studied seven patients with idiopathic Bence Jones proteinuria (excretion greater than 1.0 g per 24 hours) who did not have acquired Fanconi's syndrome or an intact monoclonal immunoglobulin in the serum. None had evidence of overt multiple myeloma, of its variants, of systemic amyloidosis, or of malignant lymphopro... | [
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0.015764130279421806,
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0.04107090085744858,
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0.019757622852921486,
0.04473260045051575,
0.005045... |
10,007,398 | Socioeconomic evaluation of a state-funded comprehensive hemophilia-care program. | [
0.031119773164391518,
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0.012385505251586437,
0.03810105100274086,
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0.... |
10,007,399 | To assess the effectiveness, cost, and socioeconomic gains associated with a comprehensive state-funded hemophilia program, we compared data from a three-year experience with such a program in Rhode Island with those from the preceding year. Self-treatment, integration of children into school, and achieving satisfying ... | [
-0.0002635743876453489,
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0.024967167526483536,
0.005200093612074852,
0.00442102923989296,
-0.04312123730778694,
0.0... |
10,007,400 | Fetal surgery for congenital hydronephrosis. | [
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0.007916716858744621,
0.055542442947626114,
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0.022030320018529892,
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-0.07975050061941147,
... |
10,007,401 | Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 10-1982. Male child with atelectasis of the left lung and hilar calcification. | [
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0.010329868644475937,
0.007867250591516495,
-0.0009358516545034945,
-0.020270749926567078,
0.009... |
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