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10,008,002 | Maldistribution with respect of medical practice location and specialty continues to present barriers to quality care for many Americans. Residents of rural communities in Colorado often lack access to health care services appropriate in number and nature to their needs. A valid determination of the severity of inacces... | [
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10,008,003 | Infectious disease in a total institution: a study of the influenza epidemic of 1978 on a college campus. | [
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10,008,004 | The influenza epidemic of 1978 was studied on a college campus, since a college is a type of "total institution" in which work, residence, and recreation are all concentrated in one organization with clearly delineated social boundaries and a unique social structure, A survey of a sample of 418 persons (378 students, 4... | [
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10,008,005 | [Short presentation of the research project "Sociotherapy with Delinquents"]. | [
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10,008,006 | [Drive representation, orienting reflex, alarm reaction. A sketch of subject matter and research logic in psychosomatics]. | [
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10,008,007 | Adjuvant therapies of cancer. | [
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10,008,008 | Metastatic potential of metastases, tumor cell heterogeneity, and therapeutic implications. | [
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10,008,009 | The metastasizing capacity of spontaneous metastases of several murine tumors of different histology, origin, and disseminative pattern was investigated to test the hypothesis that metastases originate from various subpopulations within the primary tumor. Overall, tumor cells from individual metastases did not show gre... | [
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10,008,010 | Early results of combined modality therapy of patients with Ewing's sarcoma. | [
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10,008,011 | Fourteen patients with localized Ewing's sarcoma were treated with radiation therapy to the involved bone and systemic chemotherapy. Nine patients remained free of disease for a median follow-up period of 3 years. The actuarial 5-year disease-free survival rate is 60%. | [
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10,008,012 | Natural history of breast cancer. | [
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10,008,013 | Retrospective analysis was made of 3,918 cases of breast cancer seen during 1954-1964. Median survival was 4.5 years and 30% of patients survived through a 10-year period. For stages I, II, and III patients, the mortality increased during 1-4 years after diagnosis and then slowly declined. Beyond 15 years, stage III pa... | [
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10,008,014 | Short-term and long-term effects of chemoimmunotherapy on granulopoiesis: adjuvant therapy of breast cancer. | [
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10,008,015 | The effect of adjuvant chemoimmunotherapy on normal human granulopoiesis has been studied. The short-term pattern of hemopoietic depletion and regeneration confirms that human bone marrow shows reaction to cytotoxic agents similarly to that observed in animal experiments. A regenerative response to the drug-induced dep... | [
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10,008,016 | Radiotherapy as adjuvant local therapy of local tumors. | [
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10,008,017 | Chemotherapy of metastatic gastrointestinal cancers: prospects for future adjuvant systemic therapies. | [
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10,008,018 | Overall survival enhancement for patients with gastrointestinal malignancies is most likely to come from the integration of active systemic drug therapies into combined modality programs, applied in the surgical adjuvant or locoregional disease setting. Recent results of chemotherapy trials in advanced disease are disc... | [
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10,008,019 | Long-term costs of adjuvant radiotherapy. | [
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10,008,020 | Long-term cost of combined radiotherapy and chemotherapy. | [
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10,008,021 | Complications after treatment of Hodgkin's disease are a good model to evaluate the long-term cost of combined chemo- and radiotherapy. Secondary malignancies and mainly acute myelocytic leukemias are the main complications. The 35 of 1,889 cases reported represent increased risk by factor 129. Often preceded by a leuk... | [
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10,008,022 | Studies of clonogenic human tumor stem cells. | [
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10,008,023 | In vitro tissue culture methods for cloning human tumor cells from fresh biopsy samples appear to provide a simple yet quantitative approach to study the biology and chemosensitivity of neoplastic cells which are likely to be responsible for micrometastasis and tumor progression in vivo. Use of this assay technique may... | [
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10,008,024 | Pericellular collagen in alcoholics with liver cirrhosis. | [
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10,008,025 | Therapy with enzyme inducing drugs may improve the clinical state of alcoholics with liver cirrhosis. The histological changes associated with the therapy were investigated by comparing liver biopsies before and after phenobarbital and medroxyprogesterone acetate treatment, known inducers of hepatic microsomal enzyme s... | [
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10,008,026 | The prevention of cyclophosphamide-induced cystitis in mice by disulfiram. | [
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10,008,027 | Cyclophosphamide administered intraperitoneally to mice at a dose of 100 mg/kg caused a dose related increase in urinary bladder weight within 48 hours of treatment. Disulfiram effectively prevented cyclophosphamide-induced increase in bladder weight when disulfiram was administered by either the oral or intraperitonea... | [
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10,008,028 | Doisynolic acids: potent estrogens with very low affinity for estrogen receptors. | [
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10,008,029 | Doisynolic acids are alkaline degradation products of steroidal estrogens. While these doisynolic acids are potent estrogens, some being more estrogenic than estradiol itself, they bind to cytoplasmic estrogen receptors only feebly compared with estradiol. | [
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10,008,030 | Chronic lithium decreases blood pressure in spontaneously hypertensive rats. | [
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10,008,031 | The effects of chronic lithium treatment on the blood pressure of spontaneously hypertensive rats were examined. Treated rats were fed a pelleted solid diet containing 1.696 g LiCl (40 mmol) /Kg diet. Control rats received a similar diet lacking the lithium. Rats were fed their respective diet for 21 days at which time... | [
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10,008,032 | Effect of arterial-venous plasma concentration differences on the determination of mean residence time of drugs in the body. | [
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10,008,033 | Using dogs or rabbits as model animals the effect of arterial-venous plasma concentration differences of propranolol, procainamide, griseofulvin, furosemide and theophylline on the determination of mean residence time (MRT) following intravenous administration was evaluated using standard methods. The MRT values calcul... | [
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10,008,034 | Effect of phospholipase C on lipid peroxidation of rat liver mitochondria. | [
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10,008,035 | Effect of phospholipase C on lipid peroxidation in rat liver mitochondria was studied. The lipid peroxidation of mitochondria in the presence of ascorbic acid and Fe2+ (FeSO4) was inhibited by approximately 45% after pretreatment of phospholipase C for 30 min. However, when phosphatidylcholine instead of mitochondria w... | [
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10,008,036 | Effect of oral hypoglycemic drugs on heart norepinephrine (NE) in rats and mice. | [
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10,008,037 | We studied the effect of oral hypoglycemic drugs on heart NE in normal and diabetic animals as a possible model for obtaining some insight into the mechanism for the alleged cardiotoxicity of these drugs in diabetic humans. The biguanides, but not the sulfonylureas, lowered NE in the hearts of rats and mice. Our result... | [
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10,008,038 | Metabolism of N-acetyl-L-ethionine sulfoxide in rats. | [
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10,008,039 | N-Acetyl-L-ethionine sulfoxide, the main urinary metabolic product of L-ethionine in rats, is produced and excreted by hepatocytes, as shown by its identification in liver extracts of rats administered L-ethionine and in the cultivation medium from primary culture of rat hepatocytes incubated with L-[ethyl-1-14C] ethio... | [
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0.0016116690821945667,
-0.01675425097346306,
0... |
10,008,040 | The effect of running on the osteoarthritic joint: an experimental matched-pair study with rabbits. | [
0.07093299180269241,
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0.0739450603723526,
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0.027808474376797676,
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0.13306599855422974,
0.06603287160396576,
0.02453410... |
10,008,041 | Opinions differ on the effects of running on joints. The progression of osteoarthritis and selection makes it difficult to evaluate the effects of increased motion load on joints. The effects of treadmill running on experimentally produced unilateral osteoarthritis of the knee was estimated in a matched-pair study with... | [
0.08094654977321625,
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0.07376439869403839,
0.0272709... |
10,008,042 | The clinical assessment of sacro-iliac joint involvement in ankylosing spondylitis. | [
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0.13224852085113525,
0.024187741801142693,
0.07... |
10,008,043 | The clinical significance of pain threshold measurements. | [
0.05239133536815643,
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-0.005135565530508757,
0.11662664264440536,
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0... |
10,008,044 | Pain is an experience common to us all. There are various methods of attempting to measure pain in an individual. Pain threshold would appear to be the most useful of these as it is atraumatic and repeatable over long periods in healthy individuals. Various factors affect pain threshold such as anxiety. There are a num... | [
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0.043974462896585464,
0.02984732575714588,
0.05013... |
10,008,045 | Pulseless disease of the elderly: an unusual presentation of giant cell (temporal) arteritis. | [
0.0021359864622354507,
0.1088361144065857,
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0.004401676822453737,
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0.02922392077744007,
0.006... |
10,008,046 | Measurement of radiographic joint space in the rheumatoid knee: correlation with obesity, disease duration, and other factors. | [
0.017363471910357475,
0.02013925090432167,
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0.03525448217988014,
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0.04420732334256172,
0.08621849864721298,
0.043451551... |
10,008,047 | A new and highly reproducible method for measuring radiographic joint space in the rheumatoid knee is described. The joint space was measured in radiographs of the knees of 120 patients with rheumatoid arthritis and correlated by computer analysis with age, sex, duration of disease, erosions, degenerative change, thera... | [
0.006486689206212759,
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0.022766316309571266,
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0.05335609242320061,
0.07958907634019852,
0.02657... |
10,008,048 | [Advantages of linear tomography in plain roentgenography of small intrasellar space-occupying processes (author's transl)]. | [
0.028860224410891533,
-0.04376113414764404,
0.06981179118156433,
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0.04904541000723839,
0.08290138840675354,
-0.024250350892543793,
0.00... |
10,008,049 | Diagnosis of small intrasellar space-occupying processes, known as microadenomas, requires a subtle study of the structural conditions of the floor and anterior wall of the sella. The intended aim cannot be achieved by means of processes of measurement technology. Linear tomography, nowadays hardly used in the skull re... | [
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0.07338692992925644,
-0.01549056451767683,
0.019831977784633636,
0.05810... |
10,008,050 | [Lipohaemarthrosis (author's transl)]. | [
-0.009962872602045536,
-0.034234244376420975,
-0.00887184590101242,
0.04798974096775055,
-0.13415367901325226,
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0.014836619608104229,
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-0.014936883002519608,
-0.05932943522930145,
... |
10,008,051 | Besides the presence of blood in an injured joint, fat-containing blood can also be found in the joint with intra-articular fractures. This condition, which can be demonstrated by x-ray film, is known as lipohaemarthrosis. We found this to be the case in 8 out of 295 patients with shoulder dislocation. The origin, sign... | [
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0.02302381582558155,
0.040376774966716766,
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0.038426246494054794,
0.06822311878204346,
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-0.03566776588559151,
0.046772684901952744,
-0.03212348371744156,
-0.0... |
10,008,052 | [Radiological and scintiscan diagnosis and follow-up in plasmocytoma (author's transl)]. | [
0.0014706586953252554,
0.004744910169392824,
-0.032828111201524734,
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0.013360572047531605,
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0.024634594097733498,
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-0.008657417260110378,
0.015208830125629902,
... |
10,008,053 | The results of conventional x-ray examination and skeleton scintiscanning in 32 patients with multiple or monostotic affection of the bones in plasmocytoma in primary diagnosis and after radiation treatment of individual osseous foci, are presented in a comparative study. 15% of the roentgenologically established defec... | [
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0.023116396740078926,
0.05666249617934227,
0... |
10,008,054 | [A new method for puncture and marking of non-palpable breast-lesions (author's transl)]. | [
0.10387059301137924,
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0.015950728207826614,
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-0.02629282884299755,
0.0877... |
10,008,055 | A mammographic cone with a narrow grid of some hundred small holes makes possible the localisation of nonpalpable breast-tumors. The puncture strict repeating the angle of the imaging x-ray-beam guarantees exact needle position for aspiration biopsy and preoperative marking of suspicious lesions using a thin, flexible ... | [
0.08228837698698044,
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0.03838720917701721,
0.008179252967238426,
-0.008604751899838448,
0.0371... |
10,008,056 | [The value of the x-ray spectrum with regard to x-ray filtration (author's transl)]. | [
0.02305063232779503,
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0.023290926590561867,
0.016742024570703506,
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0.01623636484146118,
-0.05226480960845947,
0.04191344976425171,
0.09072... |
10,008,057 | After some preliminary remarks on the production and spectral composition of X-Rays it is demonstrated, how the total filtration of the X-Rays including the filtration in the anode can be found from the X-Ray Bremsspektrum. The curves for determining this filtration include filters up to 50 mm AI-Equivalent for 40 to 1... | [
0.013734806329011917,
0.02336367778480053,
0.002988907042890787,
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0.03643767163157463,
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0.07021809369325638,
0.02133757621049881,
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-0.010206514038145542,
0.007519209757447243,
-0.12342450022697449,
0.06955663859844208,
0.0377075... |
10,008,058 | [Polyostotic fibrous dysplasia of bone with Paget -- like changes of the skull and facial bones -- radiological features and diagnostic problems (author's transl)]. | [
-0.04624259099364281,
0.02143518067896366,
0.04972513020038605,
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0.07220868021249771,
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0.046342600136995316,
0.009515956044197083,
0.043062902987003326,
-0.01239938847720623,
0.01... |
10,008,059 | [Degree of spondylolisthesis -- use and significance of different measuring methods (author's transl)]. | [
0.030604491010308266,
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0.03626515343785286,
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0.0666063129901886,
0.04602396488189697,
0.02765890583395958,
0.03271... |
10,008,060 | [Annual review of surgery]. | [
-0.02557566575706005,
0.046004097908735275,
-0.039538998156785965,
0.004235478583723307,
-0.09977210313081741,
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0.002738910261541605,
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0.0013705766759812832,
-0.006577824708074331,
0.07190621644258499,
-0.014115926809608936,
0... |
10,008,061 | [Diagnosis and treatment of duodenal ulcer perforation (defense of the Taylor-Quenu method]. | [
0.06029217690229416,
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-0.024960996583104134,
0.07002213597297668,
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0.05862246826291084,
0.054343223571777344,
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0.03979157283902168,
-0.0003297360963188112,
0.022503452375531197,
0.015... |
10,008,062 | [Surgical treatment of pathologic obesity]. | [
0.04237325116991997,
0.056292273104190826,
-0.03181270509958267,
0.06631498783826828,
-0.10685417056083679,
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0.025697436183691025,
0.0337570384144783,
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-0.04759039357304573,
-0.019473861902952194,
0.005550514440983534,
-0.00... |
10,008,063 | [Gas gangrene and anaerobic cellulitis]. | [
-0.008495640009641647,
-0.007516175042837858,
-0.07087894529104233,
0.04030173644423485,
-0.03488107770681381,
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0.12394548952579498,
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0.013007673434913158,
-0.007333782035857439,
-0.0567794144153595,
-0.02684398554265499,
0.05... |
10,008,064 | [Current surgical aspects of superior cava syndromes]. | [
-0.0009329654276371002,
-0.005408767145127058,
0.023585177958011627,
-0.024298587813973427,
-0.12639012932777405,
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0.03324521332979202,
-0.001645417301915586,
0.011143709532916546,
0.023149190470576286,
0... |
10,008,065 | [Cancer of the porta hepatis]. | [
0.019394194707274437,
0.026378672569990158,
-0.10102774202823639,
-0.057741012424230576,
-0.07212454080581665,
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0.026177311316132545,
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... |
10,008,066 | Prediction and diagnosis: an experimental comparison. | [
0.02084372006356716,
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0.011139677837491035,
0.06509115546941757,
0.044581398367881775,
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0.010988256894052029,
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0.03668926656246185,
0.1080643... |
10,008,067 | Memory for the spatial layout of the everyday physical environment: differential rates of acquisition of different types of information. | [
0.16747795045375824,
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0.048144083470106125,
0.043295517563819885,
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0.03216462582349777,
0.02612718567252159,
0.07787829637527466,
0.028227735310792923,
0.064... |
10,008,068 | Stability and change in parental attitudes following an infant's birth into traditional and nontraditional Swedish families. | [
0.050436731427907944,
0.048627134412527084,
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0.030075659975409508,
0.11638316512107849,
0.024087686091661453,
-0.03131600096821785,
-0.... |
10,008,069 | [The value of serum ferritin, serum iron and iron-binding capacity in the differential diagnosis of microcytic hypochromic anemia]. | [
0.007347926031798124,
0.019092939794063568,
-0.10357367992401123,
0.09705426543951035,
0.017931053414940834,
0.017669470980763435,
0.025808971375226974,
0.12067875266075134,
0.002763755852356553,
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-0.06719297170639038,
-0.060763925313949585,
-0.054158780723810196,
-0.0... |
10,008,070 | Ferritin, iron, total iron binding capacity and transferrin saturation were measured in the serum of 247 patients with microcytic hypochromic anemia. Differentiation into various categories of microcytic hypochromic anemia was based on clinical criteria and on the response to iron treatment. This produced 147 patients ... | [
-0.018783634528517723,
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0.07218081504106522,
0.001405796268954873,
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0.036886878311634064,
0.12098803371191025,
0.03758537769317627,
-0.07785820215940475,
-0.05545256286859512,
-0.01565614342689514,
-0.050707437098026276,
-0.0... |
10,008,071 | [Sweet syndrome. Apropos of 6 cases]. | [
0.00470483023673296,
-0.06390015780925751,
-0.02068697102367878,
0.08869629353284836,
-0.08472463488578796,
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0.07962841540575027,
0.0916304960846901,
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0.07600798457860947,
0.06954630464315414,
0.05115073174238205,
-0.0467505119740963,
-0.02545785... |
10,008,072 | [IgG-IgM cryoglobulinemia with a purpura-arthralgia-nephritis syndrome]. | [
-0.04651833325624466,
-0.00029855340835638344,
-0.012114658951759338,
0.07958395034074783,
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0.03917798027396202,
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0.013208096846938133,
-0.08073428273200989,
-0.004211691673845053,
0.02292175218462944,
0.08... |
10,008,073 | The clinical and laboratory features in 7 patients with essential mixed cryoglobulinemia are presented. The clinical picture was characterized by arthralgia, purpura and glomerulonephritis (3 patients). The cryoprecipitate consisted of IgM and IgG, the IgM being monoclonal (3 patients) with anti-IgG activity. Depressed... | [
0.006151952780783176,
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0.029130440205335617,
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-0.079666867852211,
-0.035813864320516586,
0.01564209535717964,
0.0731906... |
10,008,074 | [Autopsies--valuable or unnecessary?]. | [
-0.12033374607563019,
0.14357048273086548,
-0.03839445486664772,
-0.08237716555595398,
0.038624025881290436,
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0.10390093922615051,
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0.04708573967218399,
0.058614492416381836,
-0.025237787514925003,
0.05983... |
10,008,075 | [Autopsies with unsatisfactory results]. | [
-0.08818711340427399,
0.04481491073966026,
0.002018782775849104,
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0.04453791305422783,
0.0729... |
10,008,076 | Autopsies are intended to provide information about the main disease process and the cause of death, and also to disclose relevant secondary findings. A review of 3076 autopsy protocols yielded 113 cases (3.7%) with unsatisfactory results. Of these, 56% constituted a first group in which substantial findings concerning... | [
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0.03278570622205734,
0.062017057090997696,
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0.010294914245605469,
0.0... |
10,008,077 | [Postoperative course in primary aldosteronism]. | [
0.011834581382572651,
0.032699476927518845,
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0.07412116229534149,
0.013464504852890968,
0.... |
10,008,078 | [Behavior of high-density lipoproteins in drug lipid-lowering treatment]. | [
0.03179005905985832,
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0.03244704008102417,
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0.0... |
10,008,079 | Changes in serum lipids, the individual lipoprotein fractions after ultracentrifugation and the apoproteins B, A1 and A2 were studied in 66 patients with primary hypercholesterolemia under treatment with different lipid-lowering agents. After 3 months with dietary treatment alone and a 4-week placebo period the patient... | [
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10,008,080 | The biological effects of low-level ionizing radiation. | [
0.09780851751565933,
0.023251991719007492,
0.03550896793603897,
0.09434863179922104,
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0.0687580555677414,
0.095590... |
10,008,081 | How an animal virus gets into and out of its host cell. | [
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0.02901763655245304,
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0.06018539518117905,
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-0.... |
10,008,082 | Environmental uses of the NIH-EPA chemical information system. | [
0.008594207465648651,
0.09047316759824753,
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10,008,083 | A publicly accessible computer system for chemical information has been developed jointly by a number of agencies of the U.S. government. The system contains spectroscopic, crystallographic, toxicological, and regulatory data for more than 200,000 chemicals. The entire data base may be searched for a particular chemica... | [
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10,008,084 | A new look inside the sickle erythrocyte. | [
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10,008,085 | An inhibitor of the binding of thyroid hormones to serum proteins is present in extrathyroidal tissues. | [
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10,008,086 | Extrathyroidal tissues of man and the rat contain a potent inhibitor of the binding of thyroid hormones to serum proteins and to an anion-exchange resin. The inhibitor is heat-labile and nondialyzable. It acts by reducing the binding affinity of thyroid hormones to serum proteins, not by reducing the number of binding ... | [
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0.0002622584579512477,
... |
10,008,087 | Recombinant inversion chromosomes in phenotypically normal chickens. | [
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0.028084898367524147,
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10,008,088 | Some progeny resulting from interbreeding of individuals heterozygous for a pericentric inversion of chromosome 1 in the chicken have the two complementary types of recombinant chromosomes arising from a single crossing-over within the inverted segment. These individuals are capable of reproduction. Their progeny can h... | [
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0.020557057112455368,
0.08024311065673828,
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10,008,089 | Polyamines inhibit the protein kinase 380--catalyzed phosphorylation of eukaryotic initiation factor 2 alpha. | [
-0.003850160166621208,
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0.11402222514152527,
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0.0... |
10,008,090 | Polyamines putrescine, spermidine, and spermine specifically inhibit the PK 380--catalyzed phosphorylation of eukaryotic initiation factor 2 alpha (eIF-2 alpha). Since te PK 380--dependent phosphorylation of eIF-2 alpha inhibits the initiation or protein synthesis, the possibility exists that the polyamines enhance pro... | [
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0.0448319... |
10,008,091 | Cancer in nickel-processing workers in New Caledonia. | [
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0.030225476250052452,
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0.016394969075918198,
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0.037484828382730484,
-0.0... |
10,008,092 | Defining death. | [
0.012023281306028366,
0.06528760492801666,
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10,008,093 | Biological markers for chemical exposure. | [
0.07524314522743225,
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0.007102993782609701,
0.01405... |
10,008,094 | A new marker for diabetes. | [
-0.011275810189545155,
0.012363415211439133,
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0.06635840237140656,
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-0.05895... |
10,008,095 | Identification of a BALB/c H-2Ld gene by DNA-mediated gene transfer. | [
-0.09516920894384384,
0.013922122307121754,
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10,008,096 | Gene transfer and immunoselection were used in the identification of a BALB/c genomic clone containing an H-2Ld gene (clone 27.5). Transformation of thymidine kinase-negative C3H mouse L cells with the cloned 27.5 DNA together with the herpes simplex virus tk gene produced transformants expressing Ld molecules detected... | [
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0.015086045488715172,
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0.005750753916800022,
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10,008,097 | DNA sequence of a gene encoding a BALB/c mouse Ld transplantation antigen. | [
-0.09580336511135101,
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-0.03666310757398605,
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0.04930184409022331,
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-0.06893792003393173,
-0.02... |
10,008,098 | The sequence of a gene, denoted 27.5, encoding a transplantation antigen for the BALB/c mouse has been determined. Gene transfer studies and comparison of the translated sequence with the partial amino acid sequence of the Ld transplantation antigen establish that gene 27.5 encodes an Ld polypeptide. A comparison of th... | [
-0.09668450057506561,
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10,008,099 | Histone proteins in HeLa S3 cells are synthesized in a cell cycle stage specific manner. | [
-0.035023752599954605,
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-0.12272913753986359,
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0.03365983068943024,
0.02522638626396656,
0.010143899358808994,
0.0025825058110058308,
0.01... |
10,008,100 | The synthesis of histone proteins in G1 and S phase HeLa S3 cells was examined by two-dimensional electrophoretic fractionation of nuclear and total cellular proteins. Newly synthesized histones were detected only in S phase cells. Histone messenger RNA sequences, as detected by hybridization with cloned human histone ... | [
0.007292419672012329,
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0.026824558153748512,
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10,008,101 | Primary changes of membrane currents during retention of associative learning. | [
0.05623567849397659,
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0.019632628187537193,
0.06785300374031067,
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0.009204345755279064,
0.02724236622452736,
0.06104307621717453,
-0.06540597230195999,
0.098237834... |
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