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10,008,903 | A method is described utilizing repetitive electrical stimulation for the production of long-term continuous pain which approaches the quality of clinical pain. This technique provides for on-line monitoring of actual power delivered to the subject. Incremental stimuli of high and low intensities were randomly superimp... | [
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10,008,904 | Operant control and cat locomotion. | [
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10,008,905 | An operant conditioning history can produce highly uniform kinematic performances by cats on a motor-driven treadmill, but in the present work there was additional stimulus control such that the animals moved smoothly backward or forward on the belt, "startled," or reached for a food tray at the front of the chamber. T... | [
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10,008,906 | Standardized technique for diagnosis of tarsal tunnel syndrome. | [
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10,008,907 | Incidence of Scheuermann's disease. Preliminary report. | [
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10,008,908 | This is a report on a study of 96 students aged 17 and 18 at two of our local schools. Each student completed a questionnaire, underwent a simple examination of the spine and a measurement of the passive stretch in the hamstring muscles, and had a lateral X-ray of the dorsal and upper lumbar spine. An overall X-ray evi... | [
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10,008,909 | Application of 31P-NMR spectroscopy to the study of striated muscle metabolism. | [
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10,008,910 | This review presents the principles and limitations of phosphorus nuclear magnetic resonance (31P-NMR) spectroscopy as applied to the study of striated muscle metabolism. Application of the techniques discussed include noninvasive measurement of high-energy phosphate, intracellular pH, intracellular free Mg2+, and meta... | [
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10,008,911 | Tonic force maintenance with reduced shortening velocity in arterial smooth muscle. | [
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10,008,912 | The isotonic shortening velocity of swine carotid media tissues contracting in response to high K+, histamine, norepinephrine, or AC electrical stimulation rapidly increased to a maximum value and then declined to a steady-state level while force was still increasing or steady. The maximum shortening velocity calculate... | [
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10,008,913 | Binding of peanut lectin to specific epithelial cell types in kidney. | [
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10,008,914 | The binding of peanut agglutinin (PNA) to epithelial membranes of the rabbit kidney was evaluated at the light- and electron-microscope level using PNA conjugated to horseradish peroxidase. In the renal cortex and outer stripe of the medulla PNA appears to bind exclusively to the luminal membrane of intercalated cells ... | [
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10,008,915 | Mechanics and energetics of muscle contraction in normal and dystrophic chickens. | [
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10,008,916 | Energy liberation and isometric force generation were compared at 25 degrees C in isolated normal (n = 15) and dystrophic (n = 18) posterior latissimus dorsi muscles (PLD) from 16- to 33-day-old chickens. Twitch-energy liberation in dystrophic muscle decreased by 27 +/- 6%, and force per cross-sectional area decreased ... | [
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10,008,917 | Contraction of arterial smooth muscle induced by magnesium ions. | [
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10,008,918 | Dose-response relationships for Mg2+ in a Mg2+-free bathing solution were obtained with isolated canine femoral arteries. At concentrations less than 5 mM, relaxant responses appeared in the preparations. In a concentration range of 10-20 mM, however, every one of the preparations invariably showed dose-dependent contr... | [
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10,008,919 | Depolarization-induced contractile activity of smooth muscle in calcium-free solution. | [
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10,008,920 | In calcium-free solution, strips of cat intestinal muscle developed slow, rhythmic electrical potential changes that triggered contractions. Some strips failed to develop spontaneous electrical activity in calcium-free solution but responded with contractions to depolarization by direct electrical stimulation or by tre... | [
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10,008,921 | Effects of butyrate on ouabain-sensitive respiration of hamster brown adipocytes. | [
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10,008,922 | Brown adipose tissue is an important site of cold-induced nonshivering thermogenesis in many mammals. The plasma membrane-bound Na+-K+-ATPase has been shown to be significantly involved in this thermogenesis although its exact role is unknown at present. Evidence that coupling of oxidative phosphorylation to electron t... | [
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10,008,923 | Development of contractile properties in avian embryonic skeletal muscle. | [
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10,008,924 | The development of the twitch and tetanic responses of the embryonic chick posterior latissimus dorsi muscle has been studied during the last week in ovo. Normalized twitch and tetanic forces increased 3- and 12-fold, respectively, during this period. The changes in the kinetics of the twitch and tetanic responses diff... | [
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10,008,925 | Erythrocyte permeability to lipophilic solutes changes with temperature. | [
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10,008,926 | Studies of permeability coefficients of biological barriers to members of homologous series can provide information of value in assessing barrier characteristics. To this end, we have determined the linear diffusion coefficients of tracer water (THO), [14C]antipyrine, [14C]acetamide, and n-[14C]alcohols over the range ... | [
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10,008,927 | Potassium transport by rabbit descending colon. | [
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10,008,928 | Unidirectional mucosal-to-serosal (Jm leads to s) and serosal-to-mucosal (Js leads to m) fluxes of potassium and sodium were determined simultaneously on paired sections of descending colon from the same rabbit under short-circuit conditions. In 13-16 pairs of tissues, net potassium secretion and sodium absorption aver... | [
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10,008,929 | Amino acid supply to individual cerebral structures in awake and anesthetized rats. | [
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10,008,930 | The movement of phenylalanine from plasma into various cerebral structures was examined in detail in normal alert rats as well as in rats anesthetized with nitrous oxide, halothane, and sodium pentobarbital. Radioactive phenylalanine was infused intravenously in such a way as to rapidly establish and maintain a trace c... | [
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10,008,931 | Insulin resistance for glucose metabolism in disused soleus muscle of mice. | [
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10,008,932 | Our hypothesis was that insulin resistance for carbohydrate metabolism develops after a single day of muscular disuse. The immobilization of the mouse hindlimb for 24 h was used to produce muscular disuse (group c). As food intake was voluntarily decreased during the immobilization, two additional groups were used: gro... | [
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10,008,933 | Effect of insulin on fat and protein deposition in diabetic lean and obese rats. | [
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10,008,934 | Five-week-old male obese and lean Zucker rats were made comparably diabetic by intracardiac injections of alloxan (65-72 mg/kg body wt). Lean rats were then given daily injections of protamine zinc insulin at 3 doses: 0.25, 1.25, and 4.0 U.100 g body wt-1.day-1 for 3 wk. Obese rats received identical amounts as corresp... | [
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10,008,935 | Muscle glycogenolysis during exercise: dual control by epinephrine and contractions. | [
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10,008,936 | The interaction of epinephrine and contractions on muscle metabolism was studied in the isolated perfused rat hindquarter. Subtetanic contractions (180/min) through 20 min elicited glycogenolysis and increased phosphorylase a activity. In the soleus, a slow-twitch red muscle, these effects were transient, but when epin... | [
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10,008,937 | Role of thyroxine in coordinate control of corticosterone and CBG in postnatal development. | [
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10,008,938 | The role of thyroxine (T4) in the ontogeny of serum corticosteroid-binding globulin (CBG) and corticosterone has been studied in the rat. Daily injection of T4 (0.1 micrograms/g body wt) resulted in the precocious appearance of both CBG and corticosterone. A dose-response study revealed an increase in both CBG and cort... | [
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10,008,939 | Methodologic considerations in the study of glomerular ultrafiltration. | [
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... |
10,008,940 | Over the past decade numerous studies have detailed the dynamics of glomerular ultrafiltration. Observations in a unique strain of Munich-Wistar rats, which afford the direct measurement of intraglomerular capillary hydrostatic pressure, have determined that under normal physiologic conditions these animals are in a st... | [
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0.17... |
10,008,941 | Kinetic constants for urate transport. | [
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0.0... |
10,008,942 | Decreased luminal membrane transport of phosphate in chronic renal failure. | [
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0.0781... |
10,008,943 | To examine the effects of the hyperparathyroidism that accompanies chronic renal failure (CRF) on Pi transport across the renal proximal tubular luminal membrane, brush border membrane vesicles (BBMV) were prepared from the viable portion of the kidney of dogs with CRF or normal renal function. Initial rates of Na+ gra... | [
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0.103674... |
10,008,944 | Aldosterone and the enhanced natriuresis of hypertonic infusions in the dog. | [
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10,008,945 | The purpose of this study was to determine whether small elevations in plasma sodium concentration (PNa) were effective in decreasing aldosterone secretion and, hence, in increasing sodium excretion in dogs fed normal sodium diets. Ten dogs fed a normal sodium diet, six DOCA-treated dogs, and four adrenalectomized dogs... | [
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10,008,946 | Luminal influences on potassium secretion: chloride replacement with sulfate. | [
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10,008,947 | Electrolyte transport by the renal distal tubule of rats was studied by in vivo continuous microperfusion to determine whether replacing luminal chloride with sulfate would stimulate net potassium secretion. Results in a first series of experiments showed that replacing all Cl in the perfusion fluid with SO4 reduced ne... | [
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10,008,948 | A new method for kidney perfusion in situ: application to dynamics of autoregulation. | [
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... |
10,008,949 | A procedure for in situ perfusion of kidney was developed in which renal resistance does not rise with continued perfusion at a constant rate and renal blood flow (RBF) can be changed as a step function. The kidney of dogs anesthetized with pentobarbital-chloralose was perfused by a pulsatile syringe pump via an extrac... | [
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... |
10,008,950 | Coulometric acid-base titration in nanoliter samples with glass and antimony electrodes. | [
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10,008,951 | A modification of the coulometric acid-base titration method is described for the measurement of titratable acid and ammonium in nanoliter samples. The main components consist of a pH-seeking device and a miniaturized antimony electrode system capable of delivering OH- ions at a known rate. The modifications include us... | [
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10,008,952 | Blood sugar oscillations and duodenal migrating myoelectric complexes. | [
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10,008,953 | Blood concentration of reducing sugar and electrical activity of the duodenum were simultaneously measured in four conscious pigs, each chronically fitted with a catheter in a jugular vein, a duodenal infusion catheter, and transparietal intestinal electrodes. After a meal, blood sugar concentration exhibited cyclic va... | [
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10,008,954 | Relative contribution of fat, protein, carbohydrate, and ethanol to intestinal hyperemia. | [
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10,008,955 | The relative contribution of dietary fat, protein, carbohydrate, and ethanol to postprandial intestinal hyperemia was assessed by comparing the vascular and metabolic effects of luminal placement of various solutions prepared from standard high -fat, high-protein, and high-carbohydrate test diets, corn oil, and ethanol... | [
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10,008,956 | Nature of flow dependence of protein secretion by the exocrine pancreas. | [
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0.058812431... |
10,008,957 | It has been proposed that bidirectional and concentration-dependent fluxes of digestive enzymes across pancreatic acinar cell membranes account for secretion. One implication of such a model is that protein secretion should be a function of fluid outflow, inasmuch as flow would be required to generate the necessary con... | [
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0.07345... |
10,008,958 | Effects of individual taurine-conjugated bile acids on biliary lipid secretion and sucrose clearance in the unanesthetized dog. | [
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10,008,959 | The effect of three taurine-conjugated bile acids on bile flow, induced biliary secretion of phospholipids and cholesterol, and the hepatobiliary clearance from plasma of sucrose and erythritol (two uncharged, nonmetabolizable permeability probe molecules) was assessed in the unanesthetized bile fistula dog under stead... | [
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0.0013... |
10,008,960 | Migrating action-potential complex activity in absence of fluid production is produced by B subunit of cholera enterotoxin. | [
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0.133... |
10,008,961 | The myoelectric response and fluid output from in vivo rabbit ileal loops injected with B subunits of purified cholera enterotoxin are compared with the response to the purified cholera holotoxin. Migrating action-potential complex (MAPC) frequency is similar after injection of purified cholera toxin or B subunits. In ... | [
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10,008,962 | Permeability characteristics of bile duct in the rat. | [
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10,008,963 | To determine the permeability of the bile duct epithelium of the rat to several hydrophilic nonelectrolytes, isolated segments of rat bile duct (1-2 cm) were perfused with Ringer solution in situ. [14C]urea, [14C]erythritol, [14C]sucrose, or [3H]inulin was administered intravenously, and drops of duct perfusate were co... | [
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10,008,964 | Elevated intraluminal pressure alters rabbit small intestinal transport in vivo. | [
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10,008,965 | The effect of acutely increased intraluminal hydrostatic pressure (IHP) on rabbit jejunal, ileal, and colonic water and electrolyte transport was determined in vivo in a distended test segment and adjacent control segment using a perfusion system with [14C]polyethylene glycol as a nonabsorbable marker. Test-segment IHP... | [
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10,008,966 | Stimulus-secretion coupling and protein carboxyl methylation. | [
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10,008,967 | Gastric emptying and postprandial duodenogastric reflux in pylorectomized dogs. | [
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10,008,968 | A two-marker technique was used to determine gastric emptying rate and postprandial duodenogastric reflux rate without transpyloric intubation. The fractional gastric emptying rate in five dogs with normal pylorus was 3.0 +/- 0.3 (SE) X 10(-2)/min. In three dogs with circular pylorectomy, it was 5.8 +/- 0.8 X 10(-2)/mi... | [
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0.083... |
10,008,969 | Sense and nonsense about the Fenn effect. | [
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0.0371653... |
10,008,970 | One of the most influential papers in muscle physiology was published by W. O. Fenn (J. Physiol. London 58: 175-203) in 1923. Fenn determined the quantitative relationship between muscle energy liberation and work performance. Despite the importance of this work, the implications of Fenn's observations are sometimes mi... | [
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0.1117586195... |
10,008,971 | Left ventricular performance in conscious thyrotoxic calves. | [
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10,008,972 | Construction and characterization of branched, elastic, transparent vessel models. | [
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0.086... |
10,008,973 | A technique is presented for the construction of compliant branched vessel models. Properties include wall transparency and geometric reproduction to any scale. A method for characterization of vessel compliance is discussed, as is the requirement for hydrodynamic similarity. | [
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10,008,974 | Noninvasive measurement of systolic and diastolic blood pressure in swine. | [
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10,008,975 | Arterial blood pressure was measured noninvasively using Doppler ultrasound and an occluding cuff. The subjects were 28 domestic pigs (10-49 kg) anesthetized with pentobarbital sodium (25 mg/kg). Indirect pressure measurements were made with the Doppler unit placed over the radial or the ulnar artery proximal to the ca... | [
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... |
10,008,976 | Comparative response of the developing canine myocardium to inotropic agents. | [
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0.08915698528289795,
0.05987999588251114,
0.0015797599917277694,
0.027959341183304787,
-0.044704485684633255,
0.08173132687807083,
0.0... |
10,008,977 | Developmental changes in cardiac muscle function were assessed in isolated dog ventricular muscle strips obtained from dogs of three age groups: 2 day, 4 wk, and adult. Active tension (AT) and maximum rate of contraction and relaxation (+dT/dt, -dT/dt) increased significantly with age. Total contraction time increased ... | [
0.01799829863011837,
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0.06674835830926895,
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0.010259128175675869,
0.08653580... |
10,008,978 | When is the left ventricular pressure fall exponential? | [
-0.0008825006079860032,
0.02483738772571087,
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0.03181459382176399,
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0.08629630506038666,
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0.... |
10,008,979 | Relationships between adenosine and coronary resistance in conscious exercising dogs. | [
0.04687700793147087,
0.022793883457779884,
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-0.01238148845732212,
0.083707... |
10,008,980 | The relation between myocardial adenosine content, coronary sinus plasma concentration, and coronary vascular resistance was studied in conscious dogs during rest or treadmill exercise. Exercise at 5 mi/h for 7 min on a 20% slope had a significant threefold increase in cardiac work over that of dogs at rest. Exercise i... | [
0.05849400535225868,
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0.006667526438832283,
0.022393368184566498,
0.09255... |
10,008,981 | Adaptive changes of pyruvate oxidation in perfused heart during adrenergic stimulation. | [
0.015207717195153236,
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0.0774... |
10,008,982 | Pyruvate oxidation was studied in isolated guinea pig hearts perfused under various conditions of work and stimulated by norepinephrine. Hearts metabolized pyruvate alone or in combination with 3-hydroxybutyrate or acetate as substrate. [1-14C]-pyruvate-dependent 14CO2 release into the venous effluent (MVpyr) was, like... | [
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0.002818852663040161,
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0.05378633... |
10,008,983 | Acute interaction of vasopressin and neurogenic mechanisms in DOC-salt hypertension. | [
-0.05445833131670952,
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0.... |
10,008,984 | We investigated the relative role of vasopressin and neurogenic factors in the control of vascular resistance in rats treated with desoxycorticosterone (DOC) and salt and in control rats. DOC-salt-treated rats had elevated hindquarter vascular resistance (P less than 0.05). Vasopressin and neurogenic tone contributed s... | [
0.006848632358014584,
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0.... |
10,008,985 | Pressor response to vasopressin and impaired baroreflex function in DOC-salt hypertension. | [
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0.021009264513850212,
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0.04603416100144386,
0.0... |
10,008,986 | Baroreflexes and pressor responses to intravenous arginine vasopressin (AVP) and phenylephrine (PE) were evaluated in conscious, less severely hypertensive desoxycorticosterone (DOC)-salt-treated rats, hypertensive DOC-salt-treated rats, and control rats (n = 6, each group). Pressor responses were retested after gangli... | [
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0.04304204881191254,
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0.021329790353775024,
0.015399225056171417,
0.0032852147705852985,
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0.029... |
10,008,987 | Fetal intestinal oxygen consumption at various levels of oxygenation. | [
0.049698784947395325,
0.0007783221080899239,
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0.07427149266004562,
0.05436372384428978,
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0.02441268414258957,
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-0.012... |
10,008,988 | In seven chronically catheterized fetal lambs, blood flow and oxygen consumption (VO2) in the combined small and large intestines were determined at various oxygen concentrations in fetal arterial blood (CaO2). Intestinal blood flow (Qi) was measured with the radioactive-microsphere technique; intestinal oxygen deliver... | [
0.022049767896533012,
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0.019778413698077202,
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-0.05196864530444145,
0.0305... |
10,008,989 | Blood flow and ultrastructure in ischemic myocardium of cats given dexamethasone. | [
0.05193371698260307,
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0.04645124077796936,
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0.010052759200334549,
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0.0801... |
10,008,990 | Regional myocardial blood flow or myocardial creatine kinase activity and ultrastructure was studied in anesthetized cats subjected to sham operation, 5 h of circumflex-artery ligation, or 2 h of coronary-artery ligation with 3 h of reperfusion. Sham-operated cats were given dexamethasone sodium phosphate (8 mg/kg iv) ... | [
0.06534077972173691,
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0.002779316157102585,
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0.04693465679883957,
0.115... |
10,008,991 | Effects of glucagon on cardiac chronotropic response to vagal stimulation in the dog. | [
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0.03090902417898178,
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0.02873163... |
10,008,992 | Glucagon accelerates the heart independent of sympathetic nervous system stimulation. The effect of glucagon on the chronotropic responses to repetitive bursts of vagal stimulation was determined in open-chest anesthesized dogs. When the cervical vagi were stimulated at constant frequencies, the change in heart rate wa... | [
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0.0003440848959144205,
... |
10,008,993 | Effects of inorganic phosphate on ion exchange, energy state, and contraction in mammalian heart. | [
-0.019113294780254364,
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0.049450360238552094,
0.035821594297885895,
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0.09996006637811661,
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0.04176882281899452,
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0.106... |
10,008,994 | Effects of inorganic phosphate (Pi) on contractile function, ionic exchange, and cellular energetic state were investigated in isolated, arterially perfused, interventricular rabbit septa. The addition of 10 or 20 mM Pi to a N-2-hydroxyethylpiperazine-N'-2-ethanesulfonic acid (HEPES) buffered perfusate showed 1) a decr... | [
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0.07758554071187973,
-0.03910238668322563,
0.04945439472794533,
0.06832374632358551,
0.098249517... |
10,008,995 | Effect of increased magnesium on recovery from ischemia in rat and rabbit hearts. | [
0.01132657565176487,
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0.05687902867794037,
0.09899860620498657,
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0.04863050952553749,
0.03421201556... |
10,008,996 | Perfusates containing high magnesium concentrations have been suggested to have a protective effect for ischemic myocardium, but the mechanism for such an effect is unclear. We investigated the recovery of isolated perfused rabbit and rat hearts from ischemia under varied conditions of increased Mg. Hearts were made is... | [
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0.0668150931596756,
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0.048029810190200806,
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0.06058430299162865,
0.09092966467142105,
0.09... |
10,008,997 | Importance of injection site for coronary blood flow determinations by microspheres in rats. | [
0.09701638668775558,
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0.005970016121864319,
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0.101... |
10,008,998 | Because coronary blood flow (CBF) determinations require that blood and microspheres be uniformly mixed in the root of the aorta, we developed a technique of left-atrial (LA) catheterization in rats and compared the variability of results obtained by LA injection and left-ventricular (LV) injection as regards systemic ... | [
0.13891999423503876,
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0.0... |
10,008,999 | Our daily rounds of activity and temperature. | [
0.03963103145360947,
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0.0003801974526140839,
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-0.018216997385025024,
0.04932... |
10,009,000 | Functional characterization of atrial pacemaker activity. | [
-0.087506964802742,
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0.0699692890048027,
0.033071212470531464,
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0.024335522204637527,
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0.02612747624516487,
0.0502... |
10,009,001 | Control of diving responses by carotid bodies and baroreceptors in ducks. | [
0.058678608387708664,
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0.005888108629733324,
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0... |
10,009,002 | The precise role of carotid body chemoreceptors and systemic baroreceptors in cardiovascular responses during experimental diving in ducks is controversial. The diving responses of chronically baroreceptor-denervated, chemoreceptor-denervated, and combined baroreceptor- and chemoreceptor-denervated White Pekin ducks, A... | [
0.01542019471526146,
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-0.04753192141652107,
-0.06983810663223267,
-0.007751774042844772,
0.0878... |
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