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purity = 0.0 for i in set(labels): indices = (labels==i) true_clusters = true_labels[indices] if len(true_clusters)==0: continue counts = Counter(true_clusters) lab, count = counts.most_common()[0] purity += count return float(purity)/len(labe...
def purity(labels, true_labels)
Calculates the purity score for the given labels. Args: labels (array): 1D array of integers true_labels (array): 1D array of integers - true labels Returns: purity score - a float bewteen 0 and 1. Closer to 1 is better.
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# use sklearn's BallTree bt = BallTree(dim_red.T) correct = 0 for i, l in enumerate(true_labels): dist, ind = bt.query([dim_red[:,i]], k=2) closest_cell = ind[0, 1] if true_labels[closest_cell] == l: correct += 1 return float(correct)/len(true_labels)
def nne(dim_red, true_labels)
Calculates the nearest neighbor accuracy (basically leave-one-out cross validation with a 1NN classifier). Args: dim_red (array): dimensions (k, cells) true_labels (array): 1d array of integers Returns: Nearest neighbor accuracy - fraction of points for which the 1NN 1NN cl...
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N, m = data.shape cost = ll + (N*m + m*k)*(np.log(data.sum()/(N*k))) return cost
def mdl(ll, k, data)
Returns the minimum description length score of the model given its log-likelihood and k, the number of cell types. a lower cost is better...
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data_means = data.mean(1) data_vars = data.var(1) nb_indices = data_means < 0.9*data_vars return nb_indices
def find_nb_genes(data)
Finds the indices of all genes in the dataset that have a mean < 0.9 variance. Returns an array of booleans.
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val = gammaln(a+1) - gammaln(a-b+1) - gammaln(b+1) return val
def log_ncr(a, b)
Returns log(nCr(a,b)), given that b<a. Does not assume that a and b are integers (uses log-gamma).
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# TODO: include factorial... #data = data + eps genes, cells = data.shape clusters = P.shape[1] lls = np.zeros((cells, clusters)) for c in range(clusters): P_c = P[:,c].reshape((genes, 1)) R_c = R[:,c].reshape((genes, 1)) # don't need constant factors... ll =...
def nb_ll(data, P, R)
Returns the negative binomial log-likelihood of the data. Args: data (array): genes x cells P (array): NB success probability param - genes x clusters R (array): NB stopping param - genes x clusters Returns: cells x clusters array of log-likelihoods
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lls = nb_ll(data, P, R) clusters = P.shape[1] for c in range(clusters): pass return lls
def zinb_ll(data, P, R, Z)
Returns the zero-inflated negative binomial log-likelihood of the data.
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p = params[0] r = params[1] n = len(data_row) ll = np.sum(gammaln(data_row + r)) - np.sum(gammaln(data_row + 1)) ll -= n*gammaln(r) ll += np.sum(data_row)*np.log(p) ll += n*r*np.log(1-p) return -ll
def nb_ll_row(params, data_row)
returns the negative LL of a single row. Args: params (array) - [p, r] data_row (array) - 1d array of data Returns: LL of row
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n = len(data_row) d = sum(digamma(data_row + r)) - n*digamma(r) + n*np.log(r/(r+np.mean(data_row))) return d
def nb_r_deriv(r, data_row)
Derivative of log-likelihood wrt r (formula from wikipedia) Args: r (float): the R paramemter in the NB distribution data_row (array): 1d array of length cells
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means = data.mean(1) variances = data.var(1) if (means > variances).any(): raise ValueError("For NB fit, means must be less than variances") genes, cells = data.shape # method of moments P = 1.0 - means/variances R = means*(1-P)/P for i in range(genes): result = mini...
def nb_fit(data, P_init=None, R_init=None, epsilon=1e-8, max_iters=100)
Fits the NB distribution to data using method of moments. Args: data (array): genes x cells P_init (array, optional): NB success prob param - genes x 1 R_init (array, optional): NB stopping param - genes x 1 Returns: P, R - fit to data
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genes, cells = data.shape if P_init is None: P_init = np.random.random((genes, k)) if R_init is None: R_init = np.random.randint(1, data.max(), (genes, k)) R_init = R_init.astype(float) if assignments is None: _, assignments = kmeans_pp(data, k, means) means = np...
def nb_cluster(data, k, P_init=None, R_init=None, assignments=None, means=None, max_iters=10)
Performs negative binomial clustering on the given data. If some genes have mean > variance, then these genes are fitted to a Poisson distribution. Args: data (array): genes x cells k (int): number of clusters P_init (array): NB success prob param - genes x k. Default: random R_init...
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for c in range(k): if data[:,assignments==c].shape[1] == 0: _, assignments = kmeans_pp(data, k) genes, cells = data.shape nb_gene_indices = np.array([True for i in range(genes)]) for c in range(k): c_data = data[:,assignments==c] nb_gene_indices = nb_gene_indices...
def fit_cluster(data, assignments, k, P_init, R_init, means)
Fits NB/poisson params to a cluster.
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genes, cells = data.shape clusters = means.shape[1] ll = np.zeros((cells, clusters)) d0 = (data==0) d1 = (data>0) for i in range(clusters): means_i = np.tile(means[:,i], (cells, 1)) means_i = means_i.transpose() L_i = np.tile(M[:,i], (cells, 1)) L_i = L_i.tra...
def zip_ll(data, means, M)
Calculates the zero-inflated Poisson log-likelihood. Args: data (array): genes x cells means (array): genes x k M (array): genes x k - this is the zero-inflation parameter. Returns: cells x k array of log-likelihood for each cell/cluster pair.
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l = params[0] pi = params[1] d0 = (data_row==0) likelihood = d0*pi + (1-pi)*poisson.pmf(data_row, l) return -np.log(likelihood+eps).sum()
def zip_ll_row(params, data_row)
Returns the negative log-likelihood of a row given ZIP data. Args: params (list): [lambda zero-inf] data_row (array): 1d array Returns: negative log-likelihood
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all_variants = adapter.get_variants() nr_variants = all_variants.count() nr_updated = 0 with progressbar(all_variants, label="Updating variants", length=nr_variants) as bar: for variant in bar: # Do not update if the variants have the correct format if 'chrom' i...
def migrate_database(adapter)
Migrate an old loqusdb instance to 1.0 Args: adapter Returns: nr_updated(int): Number of variants that where updated
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if (len(args) != 2): print(main.__doc__) sys.exit(1); # create the document doc = libsedml.SedDocument(); doc.setLevel(1); doc.setVersion(3); # create a data description ddesc = doc.createDataDescription() ddesc.setId('data1') ddesc.setName('Oscli Timecourse data') ddesc.setSource('f...
def main (args)
Usage: create_sedml2 output-filename
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import uncurl from uncurl.preprocessing import log1p, cell_normalize from sklearn.decomposition import TruncatedSVD data_subset = data if gene_subset: gene_subset = uncurl.max_variance_genes(data) data_subset = data[gene_subset, :] tsvd = TruncatedSVD(min(8, data_subset.shap...
def preproc_data(data, gene_subset=False, **kwargs)
basic data preprocessing before running gap score Assumes that data is a matrix of shape (genes, cells). Returns a matrix of shape (cells, 8), using the first 8 SVD components. Why 8? It's an arbitrary selection...
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mins = data.min(0) maxes = data.max(0) return mins, maxes
def calculate_bounding_box(data)
Returns a 2 x m array indicating the min and max along each dimension.
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k = len(set(clustering)) Wk = km.inertia_ mins, maxes = calculate_bounding_box(data) Wk_est = [] for i in range(B): data_sample = (maxes-mins)*np.random.random(data.shape) + mins km_b = KMeans(k) km_b.fit_predict(data_sample) Wk_est.append(km_b.inertia_) Wk_e...
def calculate_gap(data, clustering, km, B=50, **kwargs)
See: https://datasciencelab.wordpress.com/2013/12/27/finding-the-k-in-k-means-clustering/ https://web.stanford.edu/~hastie/Papers/gap.pdf Returns two results: the gap score, and s_k.
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if k_min == k_max: return k_min gap_vals = [] sk_vals = [] k_range = list(range(k_min, k_max, skip)) min_k = 0 min_i = 0 for i, k in enumerate(k_range): km = KMeans(k) clusters = km.fit_predict(data) gap, sk = calculate_gap(data, clusters, km, B=B) ...
def run_gap_k_selection(data, k_min=1, k_max=50, B=5, skip=5, **kwargs)
Runs gap score for all k from k_min to k_max.
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if not headers: headers = {} try: async with self._websession.request(method, url, headers=headers, params=params, json=json) as resp: resp.raise_for_status()...
async def _request( self, method: str, url: str, *, headers: dict = None, params: dict = None, json: dict = None) -> dict
Make a request against the RainMachine device.
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if not self.enabled: return None self.in_process = True response, _ = helpers.call_api( '/cloud/v1/deviceManaged/devices', 'post', headers=helpers.req_headers(self), json=helpers.req_body(self, 'devicelist') ) ...
def get_devices(self) -> list
Return list of VeSync devices
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user_check = isinstance(self.username, str) and len(self.username) > 0 pass_check = isinstance(self.password, str) and len(self.password) > 0 if user_check and pass_check: response, _ = helpers.call_api( '/cloud/v1/user/login', 'post', ...
def login(self) -> bool
Return True if log in request succeeds
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if self.device_time_check(): if not self.in_process: outlets, switches, fans = self.get_devices() self.outlets = helpers.resolve_updates(self.outlets, outlets) self.switches = helpers.resolve_updates( self.switches, swit...
def update(self)
Fetch updated information about devices
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for outlet in self.outlets: outlet.update_energy(bypass_check)
def update_energy(self, bypass_check=False)
Fetch updated energy information about devices
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#Assumes data to be in the form of a numpy matrix (r,c) = Dat.shape Poiss = np.zeros(r) Norm = np.zeros(r) LogNorm = np.zeros(r) for i in range(r): temp = GetDistFitError(Dat[i]) Poiss[i] = temp['poiss'] Norm[i] = temp['norm'] LogNorm[i] = temp['lognorm'] ...
def DistFitDataset(Dat)
Given a data matrix, this returns the per-gene fit error for the Poisson, Normal, and Log-Normal distributions. Args: Dat (array): numpy array with shape (genes, cells) Returns: d (dict): 'poiss', 'norm', 'lognorm' give the fit error for each distribution.
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# This will overwrite the updated case with the previous one if update: adapter.add_case(existing_case) else: adapter.delete_case(case_obj) for file_type in ['vcf_path','vcf_sv_path']: if not case_obj.get(file_type): continue variant_file = case_obj[file...
def delete(adapter, case_obj, update=False, existing_case=False)
Delete a case and all of it's variants from the database. Args: adapter: Connection to database case_obj(models.Case) update(bool): If we are in the middle of an update existing_case(models.Case): If something failed during an update we need to revert ...
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case_id = case_id or case_obj['case_id'] nr_deleted = 0 start_deleting = datetime.now() chrom_time = datetime.now() current_chrom = None new_chrom = None for variant in vcf_obj: formated_variant = build_variant( variant=variant, case_obj=case_obj, ...
def delete_variants(adapter, vcf_obj, case_obj, case_id=None)
Delete variants for a case in the database Args: adapter(loqusdb.plugins.Adapter) vcf_obj(iterable(dict)) ind_positions(dict) case_id(str) Returns: nr_deleted (int): Number of deleted variants
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adapter = ctx.obj['adapter'] variant_path = os.path.abspath(variant_file) expected_type = 'snv' if sv: expected_type = 'sv' if 'sv': nr_cases = adapter.nr_cases(sv_cases=True) else: nr_cases = adapter.nr_cases(snv_cases=True) LOG.info("Found {0} {1} cases in d...
def annotate(ctx, variant_file, sv)
Annotate the variants in a VCF
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data = {'data': [{'num': num} for num in tracking_numbers]} tracking_resp = await self._request('post', API_URL_TRACK, json=data) print(tracking_resp) if not tracking_resp.get('dat'): raise InvalidTrackingNumberError('Invalid data') packages = [] f...
async def find(self, *tracking_numbers: str) -> list
Get tracking info for one or more tracking numbers.
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loglevel = "INFO" if verbose: loglevel = "DEBUG" coloredlogs.install(level=loglevel) LOG.info("Running loqusdb version %s", __version__) configs = {} if config: try: configs = yaml.safe_load(config) except yaml.YAMLError as err: LOG.warning(e...
def cli(ctx, database, username, password, authdb, port, host, uri, verbose, config, test)
loqusdb: manage a local variant count database.
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thresholds = qualitative.min(1) + (qualitative.max(1) - qualitative.min(1))/2.0 binarized = qualitative > thresholds.reshape((len(thresholds), 1)).repeat(8,1) return binarized.astype(int)
def binarize(qualitative)
binarizes an expression dataset.
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genes, cells = data.shape clusters = qualitative.shape[1] output = np.zeros((genes, clusters)) missing_indices = [] genes_included = [] qual_indices = [] thresholds = qualitative.min(1) + (qualitative.max(1) - qualitative.min(1))/2.0 pvals = np.zeros(genes) for i in range(genes)...
def qualNorm_filter_genes(data, qualitative, pval_threshold=0.05, smoothing=1e-5, eps=1e-5)
Does qualNorm but returns a filtered gene set, based on a p-value threshold.
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genes, cells = data.shape clusters = qualitative.shape[1] output = np.zeros((genes, clusters)) missing_indices = [] qual_indices = [] thresholds = qualitative.min(1) + (qualitative.max(1) - qualitative.min(1))/2.0 for i in range(genes): if qualitative[i,:].max() == -1 and qualit...
def qualNorm(data, qualitative)
Generates starting points using binarized data. If qualitative data is missing for a given gene, all of its entries should be -1 in the qualitative matrix. Args: data (array): 2d array of genes x cells qualitative (array): 2d array of numerical data - genes x clusters Returns: Array of...
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genes, cells = data.shape clusters = qualitative.shape[1] output = np.zeros((genes, clusters)) missing_indices = [] qual_indices = [] for i in range(genes): if qualitative[i,:].max() == -1 and qualitative[i,:].min() == -1: missing_indices.append(i) continue ...
def qualNormGaussian(data, qualitative)
Generates starting points using binarized data. If qualitative data is missing for a given gene, all of its entries should be -1 in the qualitative matrix. Args: data (array): 2d array of genes x cells qualitative (array): 2d array of numerical data - genes x clusters Returns: Array of...
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if getattr(sys, 'frozen', False): # py2exe, PyInstaller, cx_Freeze path = abspath(sys.executable) else: path = inspect.getabsfile(pyobject) if follow_symlinks: path = realpath(path) return dirname(path)
def script_dir(pyobject, follow_symlinks=True)
Get current script's directory Args: pyobject (Any): Any Python object in the script follow_symlinks (Optional[bool]): Follow symlinks or not. Defaults to True. Returns: str: Current script's directory
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return join(script_dir(pyobject, follow_symlinks), filename)
def script_dir_plus_file(filename, pyobject, follow_symlinks=True)
Get current script's directory and then append a filename Args: filename (str): Filename to append to directory path pyobject (Any): Any Python object in the script follow_symlinks (Optional[bool]): Follow symlinks or not. Defaults to True. Returns: str: Current script's direct...
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if not variant_id: LOG.warning("Please provide a variant id") ctx.abort() adapter = ctx.obj['adapter'] version = ctx.obj['version'] LOG.info("Search variants {0}".format(adapter)) result = adapter.get_clusters(variant_id) if result.count() == 0: LOG.info("...
def identity(ctx, variant_id)
Check how well SVs are working in the database
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if ATTR_ENTITY_REGISTRATION_AUTHORITY in self.raw: try: return self.raw[ ATTR_ENTITY_REGISTRATION_AUTHORITY][ ATTR_ENTITY_REGISTRATION_AUTHORITY_ENTITY_ID][ ATTR_DOLLAR_SIGN] except KeyError: ...
def registration_authority_entity_id(self)
Some entities return the register entity id, but other do not. Unsure if this is a bug or inconsistently registered data.
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if ATTR_ENTITY_LEGAL_FORM in self.raw: try: return LEGAL_FORMS[self.legal_jurisdiction][ self.raw[ATTR_ENTITY_LEGAL_FORM][ ATTR_ENTITY_LEGAL_FORM_CODE][ATTR_DOLLAR_SIGN] ] except KeyError: ...
def legal_form(self)
In some cases, the legal form is stored in the JSON-data. In other cases, an ELF-code, consisting of mix of exactly four letters and numbers are stored. This ELF-code can be looked up in a registry where a code maps to a organizational type. ELF-codes are not unique, it can reocc...
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child_lei = list() for d in self.raw['data']: # We're not very greedy here, but it seems some records have # lapsed even through the issuer is active if d['attributes']['relationship']['status'] in ['ACTIVE']: child_lei.append( ...
def valid_child_records(self)
Loop through data to find a valid record. Return list of LEI.
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if var_obj: variant.INFO['Obs'] = var_obj['observations'] if var_obj.get('homozygote'): variant.INFO['Hom'] = var_obj['homozygote'] if var_obj.get('hemizygote'): variant.INFO['Hem'] = var_obj['hemizygote'] return variant
def annotate_variant(variant, var_obj=None)
Annotate a cyvcf variant with observations Args: variant(cyvcf2.variant) var_obj(dict) Returns: variant(cyvcf2.variant): Annotated variant
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variant_id = get_variant_id(variant) variant_obj = adapter.get_variant(variant={'_id':variant_id}) annotated_variant = annotated_variant(variant, variant_obj) return annotated_variant
def annotate_snv(adpter, variant)
Annotate an SNV/INDEL variant Args: adapter(loqusdb.plugin.adapter) variant(cyvcf2.Variant)
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for nr_variants, variant in enumerate(vcf_obj, 1): variant_info = get_coords(variant) match = adapter.get_structural_variant(variant_info) if match: annotate_variant(variant, match) yield variant
def annotate_svs(adapter, vcf_obj)
Annotate all SV variants in a VCF Args: adapter(loqusdb.plugin.adapter) vcf_obj(cyvcf2.VCF) Yields: variant(cyvcf2.Variant)
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variants = {} for nr_variants, variant in enumerate(vcf_obj, 1): # Add the variant to current batch variants[get_variant_id(variant)] = variant # If batch len == 1000 we annotate the batch if (nr_variants % 1000) == 0: for var_obj in adapter.sea...
def annotate_snvs(adapter, vcf_obj)
Annotate all variants in a VCF Args: adapter(loqusdb.plugin.adapter) vcf_obj(cyvcf2.VCF) Yields: variant(cyvcf2.Variant): Annotated variant
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type_ = geojson["type"].lower() if type_ == "geometrycollection": geometries = [] for geometry in geojson["geometries"]: geometries.append(Geometry.from_geojson(geometry, srid=None)) return GeometryCollection(geometries, srid) elif typ...
def from_geojson(geojson, srid=4326)
Create a Geometry from a GeoJSON. The SRID can be overridden from the expected 4326.
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if SHAPELY: WKBWriter.defaults["include_srid"] = True if srid: lgeos.GEOSSetSRID(sgeom._geom, srid) return Geometry(sgeom.wkb_hex) else: raise DependencyError("Shapely")
def from_shapely(sgeom, srid=None)
Create a Geometry from a Shapely geometry and the specified SRID. The Shapely geometry will not be modified.
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return self._to_wkb(use_srid=True, dimz=self.dimz, dimm=self.dimm)
def wkb(self)
Get the geometry as an (E)WKB.
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dimz = "Z" if self.dimz else "" dimm = "M" if self.dimm else "" if self.srid: return "geometry({}{}{},{})".format(self.type, dimz, dimm, self.srid) else: return "geometry({}{}{})".format(self.type, dimz, dimm)
def postgis_type(self)
Get the type of the geometry in PostGIS format, including additional dimensions and SRID if they exist.
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if sparse.issparse(data): return sparse_poisson_ll(data, means) genes, cells = data.shape clusters = means.shape[1] ll = np.zeros((cells, clusters)) for i in range(clusters): means_i = np.tile(means[:,i], (cells, 1)) means_i = means_i.transpose() + eps #ll[:,i] =...
def poisson_ll(data, means)
Calculates the Poisson log-likelihood. Args: data (array): 2d numpy array of genes x cells means (array): 2d numpy array of genes x k Returns: cells x k array of log-likelihood for each cell/cluster pair
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p1_1 = p1 + eps p2_1 = p2 + eps return np.sum(-p2_1 + p1_1*np.log(p2_1))
def poisson_ll_2(p1, p2)
Calculates Poisson LL(p1|p2).
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# ugh... p1_ = p1 + eps p2_ = p2 + eps return np.dot(p1_-p2_, np.log(p1_/p2_))
def poisson_dist(p1, p2)
Calculates the Poisson distance between two vectors. p1 can be a sparse matrix, while p2 has to be a dense matrix.
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if not (family_file or case_id): LOG.error("Please provide a family file") ctx.abort() adapter = ctx.obj['adapter'] # Get a ped_parser.Family object from family file family = None family_id = None if family_file: with open(family_file, 'r') as family_lines: ...
def delete(ctx, family_file, family_type, case_id)
Delete the variants of a case.
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if bypass_check or (not bypass_check and self.update_time_check): self.get_weekly_energy() if 'week' in self.energy: self.get_monthly_energy() self.get_yearly_energy() if not bypass_check: self.update_energy_ts = time.t...
def update_energy(self, bypass_check: bool = False)
Builds weekly, monthly and yearly dictionaries
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body = helpers.req_body(self.manager, 'devicestatus') body['uuid'] = self.uuid body['mode'] = 'auto' response, _ = helpers.call_api( '/15a/v1/device/nightlightstatus', 'put', headers=helpers.req_headers(self.manager), json=body ...
def turn_on_nightlight(self)
Turn on nightlight
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if len(args) != 3: print(main.__doc__) sys.exit(1) d = libsedml.readSedML(args[1]); if ( d.getErrorLog().getNumFailsWithSeverity(libsedml.LIBSEDML_SEV_ERROR) > 0): print (d.getErrorLog().toString()); else: libsedml.writeSedML(d, args[2]); return 0;
def main (args)
Usage: echo_sedml input-filename output-filename
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logging.basicConfig(level=logging.INFO) async with ClientSession() as websession: try: client = Client(websession) await client.profile.login('<EMAIL>', '<PASSWORD>') _LOGGER.info('Account ID: %s', client.profile.account_id) summary = await client....
async def main() -> None
Create the aiohttp session and run the example.
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module, attr = name.rsplit('.', 1) mod = __import__(module, fromlist=[attr]) klass = getattr(mod, attr) return klass()
def my_import(name)
dynamic importing
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if FACEBOOK_APP_ID is None: log.warning("FACEBOOK_APP_ID isn't setup correctly in your settings") # make sure FACEBOOK_APP_ID is setup correct and user is authenticated if FACEBOOK_APP_ID: request = context.get('request', None) if request: return {"LIKE_BUTTON_IS_V...
def like_button_js_tag(context)
This tag will check to see if they have the FACEBOOK_LIKE_APP_ID setup correctly in the django settings, if so then it will pass the data along to the intercom_tag template to be displayed. If something isn't perfect we will return False, which will then not install the javascript since...
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if FACEBOOK_APP_ID is None: log.warning("FACEBOOK_APP_ID isn't setup correctly in your settings") # make sure INTERCOM_APPID is setup correct and user is authenticated if FACEBOOK_APP_ID: request = context.get('request', None) if request: path_to_like = ( ...
def like_button_tag(context)
This tag will check to see if they have the FACEBOOK_APP_ID setup correctly in the django settings, if so then it will pass the data along to the intercom_tag template to be displayed. If something isn't perfect we will return False, which will then not install the javascript since it i...
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# Create a query for the database # This will include more variants than we want # The rest of the calculations will be done in python query = { 'chrom': variant['chrom'], 'end_chrom': variant['end_chrom'], 'sv_type': variant['sv_t...
def get_structural_variant(self, variant)
Check if there are any overlapping sv clusters Search the sv variants with chrom start end_chrom end and sv_type Args: variant (dict): A variant dictionary Returns: variant (dict): A variant dictionary
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query = {} if chromosome: query['chrom'] = chromosome if end_chromosome: query['end_chrom'] = end_chromosome if sv_type: query['sv_type'] = sv_type if pos: if not '$and' in query: query['$and'] = []...
def get_sv_variants(self, chromosome=None, end_chromosome=None, sv_type=None, pos=None, end=None)
Return all structural variants in the database Args: chromosome (str) end_chromosome (str) sv_type (str) pos (int): Left position of SV end (int): Right position of SV Returns: variants (Iterable(Variant))
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query = {'variant_id':variant_id} identities = self.db.identity.find(query) return identities
def get_clusters(self, variant_id)
Search what clusters a variant belongs to Args: variant_id(str): From ID column in vcf Returns: clusters()
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clusters = int(clusters) func = poisson_estimate_state dist = dist.lower() if dist=='poiss' or dist=='poisson': pass elif dist=='nb': func = nb_estimate_state elif dist=='zip': func = zip_estimate_state elif dist=='lognorm' or dist=='log-normal' or dist=='lognorm...
def run_state_estimation(data, clusters, dist='Poiss', reps=1, **kwargs)
Runs state estimation for multiple initializations, returning the result with the highest log-likelihood. All the arguments are passed to the underlying state estimation functions (poisson_estimate_state, nb_estimate_state, zip_estimate_state). Args: data (array): genes x cells clusters (int): numb...
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body = helpers.req_body(self.manager, 'devicedetail') head = helpers.req_headers(self.manager) r, _ = helpers.call_api('/131airpurifier/v1/device/deviceDetail', method='post', headers=head, json=body) if r is not None and helpers.check_response(...
def get_details(self)
Build details dictionary
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if self.device_status != 'on': body = helpers.req_body(self.manager, 'devicestatus') body['uuid'] = self.uuid body['status'] = 'on' head = helpers.req_headers(self.manager) r, _ = helpers.call_api('/131airPurifier/v1/device/deviceStatus', ...
def turn_on(self)
Turn Air Purifier on
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body = helpers.req_body(self.manager, 'devicestatus') body['uuid'] = self.uuid head = helpers.req_headers(self.manager) if self.details.get('mode') != 'manual': self.mode_toggle('manual') else: if speed is not None: level = int(sel...
def fan_speed(self, speed: int = None) -> bool
Adjust Fan Speed by Specifying 1,2,3 as argument or cycle through speeds increasing by one
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head = helpers.req_headers(self.manager) body = helpers.req_body(self.manager, 'devicestatus') body['uuid'] = self.uuid if mode != body['mode'] and mode in ['sleep', 'auto', 'manual']: body['mode'] = mode if mode == 'manual': body['level']...
def mode_toggle(self, mode: str) -> bool
Set mode to manual, auto or sleep
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output = 0 output += a[0]/2 w = a[1] for n in range(2, len(a), 2): n_ = n/2 val1 = a[n] val2 = a[n+1] output += val1*np.sin(n_*x*w) output += val2*np.cos(n_*x*w) return output
def fourier_series(x, *a)
Arbitrary dimensionality fourier series. The first parameter is a_0, and the second parameter is the interval/scale parameter. The parameters are altering sin and cos paramters. n = (len(a)-2)/2
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# convert adjacency list to adjacency dict adj = {x: [] for x in range(len(distances))} for n1, n2 in edges: adj[n1].append(n2) adj[n2].append(n1) # run dijkstra's algorithm to_visit = [] new_dist = {} for n in adj[start]: heapq.heappush(to_visit, (distances[star...
def graph_distances(start, edges, distances)
Given an undirected adjacency list and a pairwise distance matrix between all nodes: calculates distances along graph from start node. Args: start (int): start node edges (list): adjacency list of tuples distances (array): 2d array of distances between nodes Returns: dict o...
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output = 0.0 for n in range(0, len(a)): output += a[n]*x**n return output
def poly_curve(x, *a)
Arbitrary dimension polynomial.
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# TODO # 1. calculate a distance matrix... distances = np.array([[sum((x - y)**2) for x in fitted_vals.T] for y in fitted_vals.T]) # 2. start from the root node/cell, calculate distance along graph distance_dict = graph_distances(starting_node, edges, distances) output = [] for i in ran...
def pseudotime(starting_node, edges, fitted_vals)
Args: starting_node (int): index of the starting node edges (list): list of tuples (node1, node2) fitted_vals (array): output of lineage (2 x cells) Returns: A 1d array containing the pseudotime value of each cell.
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# type: (str, hxl.Row) -> None countryname = country.get('#country+name+preferred') cls._countriesdata['countrynames2iso3'][countryname.upper()] = iso3 iso2 = country.get('#country+code+v_iso2') if iso2: cls._countriesdata['iso2iso3'][iso2] = iso3 ...
def _add_countriesdata(cls, iso3, country)
Set up countries data from data in form provided by UNStats and World Bank Args: iso3 (str): ISO3 code for country country (hxl.Row): Country information Returns: None
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# type: (str) -> None cls._countriesdata = dict() cls._countriesdata['countries'] = dict() cls._countriesdata['iso2iso3'] = dict() cls._countriesdata['m49iso3'] = dict() cls._countriesdata['countrynames2iso3'] = dict() cls._countriesdata['regioncodes2coun...
def set_countriesdata(cls, countries)
Set up countries data from data in form provided by UNStats and World Bank Args: countries (str): Countries data in HTML format provided by UNStats Returns: None
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# type: (bool) -> List[Dict[Dict]] if cls._countriesdata is None: countries = None if use_live: try: countries = hxl.data(cls._ochaurl) except IOError: logger.exception('Download from OCHA feed faile...
def countriesdata(cls, use_live=True)
Read countries data from OCHA countries feed (falling back to file) Args: use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. Returns: List[Dict[Dict]]: Countries dictionaries
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# type: (str) -> None if url is None: url = cls._ochaurl_int cls._ochaurl = url
def set_ocha_url(cls, url=None)
Set World Bank url from which to retrieve countries data Args: url (str): World Bank url from which to retrieve countries data. Defaults to internal value. Returns: None
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# type: (str, bool, Optional[ExceptionUpperBound]) -> Optional[Dict[str]] countriesdata = cls.countriesdata(use_live=use_live) country = countriesdata['countries'].get(iso3.upper()) if country is not None: return country if exception is not None: ...
def get_country_info_from_iso3(cls, iso3, use_live=True, exception=None)
Get country information from ISO3 code Args: iso3 (str): ISO3 code for which to get country information use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. exception (Optional[ExceptionUpperBound]): An exception to raise if cou...
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# type: (str, bool, Optional[ExceptionUpperBound]) -> Optional[str] countryinfo = cls.get_country_info_from_iso3(iso3, use_live=use_live, exception=exception) if countryinfo is not None: return countryinfo.get('#country+name+preferred') return None
def get_country_name_from_iso3(cls, iso3, use_live=True, exception=None)
Get country name from ISO3 code Args: iso3 (str): ISO3 code for which to get country name use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. exception (Optional[ExceptionUpperBound]): An exception to raise if country not found...
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# type: (str, bool, Optional[ExceptionUpperBound]) -> Optional[str] countriesdata = cls.countriesdata(use_live=use_live) iso2 = countriesdata['iso2iso3'].get(iso3.upper()) if iso2 is not None: return iso2 if exception is not None: raise exception...
def get_iso2_from_iso3(cls, iso3, use_live=True, exception=None)
Get ISO2 from ISO3 code Args: iso3 (str): ISO3 code for which to get ISO2 code use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. exception (Optional[ExceptionUpperBound]): An exception to raise if country not found. Defaults ...
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# type: (str, bool, Optional[ExceptionUpperBound]) -> Optional[Dict[str]] iso3 = cls.get_iso3_from_iso2(iso2, use_live=use_live, exception=exception) if iso3 is not None: return cls.get_country_info_from_iso3(iso3, use_live=use_live, exception=exception) return None
def get_country_info_from_iso2(cls, iso2, use_live=True, exception=None)
Get country name from ISO2 code Args: iso2 (str): ISO2 code for which to get country information use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. exception (Optional[ExceptionUpperBound]): An exception to raise if country no...
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# type: (str, bool, Optional[ExceptionUpperBound]) -> Optional[str] iso3 = cls.get_iso3_from_iso2(iso2, use_live=use_live, exception=exception) if iso3 is not None: return cls.get_country_name_from_iso3(iso3, exception=exception) return None
def get_country_name_from_iso2(cls, iso2, use_live=True, exception=None)
Get country name from ISO2 code Args: iso2 (str): ISO2 code for which to get country name use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. exception (Optional[ExceptionUpperBound]): An exception to raise if country not found...
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# type: (str, bool, Optional[ExceptionUpperBound]) -> Optional[int] countriesdata = cls.countriesdata(use_live=use_live) m49 = countriesdata['m49iso3'].get(iso3) if m49 is not None: return m49 if exception is not None: raise exception ret...
def get_m49_from_iso3(cls, iso3, use_live=True, exception=None)
Get M49 from ISO3 code Args: iso3 (str): ISO3 code for which to get M49 code use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. exception (Optional[ExceptionUpperBound]): An exception to raise if country not found. Defaults to...
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# type: (int, bool, Optional[ExceptionUpperBound]) -> Optional[Dict[str]] iso3 = cls.get_iso3_from_m49(m49, use_live=use_live, exception=exception) if iso3 is not None: return cls.get_country_info_from_iso3(iso3, exception=exception) return None
def get_country_info_from_m49(cls, m49, use_live=True, exception=None)
Get country name from M49 code Args: m49 (int): M49 numeric code for which to get country information use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. exception (Optional[ExceptionUpperBound]): An exception to raise if count...
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# type: (int, bool, Optional[ExceptionUpperBound]) -> Optional[str] iso3 = cls.get_iso3_from_m49(m49, use_live=use_live, exception=exception) if iso3 is not None: return cls.get_country_name_from_iso3(iso3, exception=exception) return None
def get_country_name_from_m49(cls, m49, use_live=True, exception=None)
Get country name from M49 code Args: m49 (int): M49 numeric code for which to get country name use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. exception (Optional[ExceptionUpperBound]): An exception to raise if country not ...
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# type: (str) -> List[str] def replace_ensure_space(word, replace, replacement): return word.replace(replace, '%s ' % replacement).replace(' ', ' ').strip() countryupper = country.upper() for abbreviation in cls.abbreviations: countryupper = replace_ensu...
def expand_countryname_abbrevs(cls, country)
Expands abbreviation(s) in country name in various ways (eg. FED -> FEDERATED, FEDERAL etc.) Args: country (str): Country with abbreviation(s)to expand Returns: List[str]: Uppercase country name with abbreviation(s) expanded in various ways
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# type: (str) -> (str, List[str]) countryupper = country.upper() words = get_words_in_sentence(countryupper) index = countryupper.find(',') if index != -1: countryupper = countryupper[:index] index = countryupper.find(':') if index != -1: ...
def simplify_countryname(cls, country)
Simplifies country name by removing descriptive text eg. DEMOCRATIC, REPUBLIC OF etc. Args: country (str): Country name to simplify Returns: Tuple[str, List[str]]: Uppercase simplified country name and list of removed words
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# type: (str, bool, Optional[ExceptionUpperBound]) -> Optional[str] countriesdata = cls.countriesdata(use_live=use_live) countryupper = country.upper() len_countryupper = len(countryupper) if len_countryupper == 3: if countryupper in countriesdata['countries'...
def get_iso3_country_code(cls, country, use_live=True, exception=None)
Get ISO3 code for cls. Only exact matches or None are returned. Args: country (str): Country for which to get ISO3 code use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. exception (Optional[ExceptionUpperBound]): An exception...
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# type: (str, bool, Optional[ExceptionUpperBound]) -> Tuple[[Optional[str], bool]] countriesdata = cls.countriesdata(use_live=use_live) iso3 = cls.get_iso3_country_code(country, use_live=use_live) # don't put exception param here as we don't wan...
def get_iso3_country_code_fuzzy(cls, country, use_live=True, exception=None)
Get ISO3 code for cls. A tuple is returned with the first value being the ISO3 code and the second showing if the match is exact or not. Args: country (str): Country for which to get ISO3 code use_live (bool): Try to get use latest data from web rather than file in package. Defa...
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# type: (Union[int,str], bool, Optional[ExceptionUpperBound]) -> List[str] countriesdata = cls.countriesdata(use_live=use_live) if isinstance(region, int): regioncode = region else: regionupper = region.upper() regioncode = countriesdata['regi...
def get_countries_in_region(cls, region, use_live=True, exception=None)
Get countries (ISO3 codes) in region Args: region (Union[int,str]): Three digit UNStats M49 region code or region name use_live (bool): Try to get use latest data from web rather than file in package. Defaults to True. exception (Optional[ExceptionUpperBound]): An exception ...
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adapter = ctx.obj['adapter'] if variant_file: load_profile_variants(adapter, variant_file) if update: update_profiles(adapter) if stats: distance_dict = profile_stats(adapter, threshold=profile_threshold) click.echo(table_from_dict(distance_dict))
def load_profile(ctx, variant_file, update, stats, profile_threshold)
Command for profiling of samples. User may upload variants used in profiling from a vcf, update the profiles for all samples, and get some stats from the profiles in the database. Profiling is used to monitor duplicates in the database. The profile is based on the variants in the 'profi...
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results = self.db.profile_variant.insert_many(profile_variants) return results
def add_profile_variants(self, profile_variants)
Add several variants to the profile_variant collection in the database Args: profile_variants(list(models.ProfileVariant))
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genes, cells = data.shape m = data.mean(1) v = data.var(1) M = (v-m)/(m**2+v-m) #M = v/(v+m**2) #M[np.isnan(M)] = 0.0 M = np.array([min(1.0, max(0.0, x)) for x in M]) L = m + v/m - 1.0 #L = (v + m**2)/m L[np.isnan(L)] = 0.0 L = np.array([max(0.0, x) for x in L]) retu...
def zip_fit_params(data)
Returns the ZIP parameters that best fit a given data set. Args: data (array): 2d array of genes x cells belonging to a given cluster Returns: L (array): 1d array of means M (array): 1d array of zero-inflation parameter
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genes, cells = data.shape init, new_assignments = kmeans_pp(data+eps, k, centers=init) centers = np.copy(init) M = np.zeros(centers.shape) assignments = new_assignments for c in range(k): centers[:,c], M[:,c] = zip_fit_params_mle(data[:, assignments==c]) for it in range(max_iter...
def zip_cluster(data, k, init=None, max_iters=100)
Performs hard EM clustering using the zero-inflated Poisson distribution. Args: data (array): A 2d array- genes x cells k (int): Number of clusters init (array, optional): Initial centers - genes x k array. Default: None, use kmeans++ max_iters (int, optional): Maximum number of ite...
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for i in range(diffusion_rounds): weights = weights*weights weights = weights/weights.sum(0) X = dim_reduce(means, weights, d) if X.shape[0]==2: return X.dot(weights) else: return X.T.dot(weights)
def diffusion_mds(means, weights, d, diffusion_rounds=10)
Dimensionality reduction using MDS, while running diffusion on W. Args: means (array): genes x clusters weights (array): clusters x cells d (int): desired dimensionality Returns: W_reduced (array): array of shape (d, cells)
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X = dim_reduce(means, weights, d) if X.shape[0]==2: return X.dot(weights) else: return X.T.dot(weights)
def mds(means, weights, d)
Dimensionality reduction using MDS. Args: means (array): genes x clusters weights (array): clusters x cells d (int): desired dimensionality Returns: W_reduced (array): array of shape (d, cells)
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genes, cells = data.shape distances = np.zeros((cells, cells)) for i in range(cells): for j in range(cells): distances[i,j] = poisson_dist(data[:,i], data[:,j]) # do MDS on the distance matrix (procedure from Wikipedia) proximity = distances**2 J = np.eye(cells) - 1./cel...
def dim_reduce_data(data, d)
Does a MDS on the data directly, not on the means. Args: data (array): genes x cells d (int): desired dimensionality Returns: X, a cells x d matrix
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LOG.debug("Getting case {0} from database".format(case.get('case_id'))) case_id = case['case_id'] return self.db.case.find_one({'case_id': case_id})
def case(self, case)
Get a case from the database Search the cases with the case id Args: case (dict): A case dictionary Returns: mongo_case (dict): A mongo case dictionary
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query = {} if snv_cases: query = {'vcf_path': {'$exists':True}} if sv_cases: query = {'vcf_sv_path': {'$exists':True}} if snv_cases and sv_cases: query = None return self.db.case.count_documents(query)
def nr_cases(self, snv_cases=None, sv_cases=None)
Return the number of cases in the database Args: snv_cases(bool): If only snv cases should be searched sv_cases(bool): If only snv cases should be searched Returns: cases (Iterable(Case)): A iterable with mongo cases
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existing_case = self.case(case) if existing_case and not update: raise CaseError("Case {} already exists".format(case['case_id'])) if existing_case: self.db.case.find_one_and_replace( {'case_id': case['case_id']}, case, ...
def add_case(self, case, update=False)
Add a case to the case collection If the case exists and update is False raise error. Args: db (MongoClient): A connection to the mongodb case (dict): A case dictionary update(bool): If existing case should be updated Returns: mongo_case_id(Obje...
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mongo_case = self.case(case) if not mongo_case: raise CaseError("Tried to delete case {0} but could not find case".format( case.get('case_id') )) LOG.info("Removing case {0} from database".format( mongo_case.get('case_id') )) ...
def delete_case(self, case)
Delete case from the database Delete a case from the database Args: case (dict): A case dictionary
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