Chunk-level Retrieval Eval
Collection
Contextualized chunk-level (query2chunk) retrieval eval for the Citras benchmark. • 46 items • Updated
chunk_id string | chunk string | source_url string | title string | chunk_idx int64 | chunk_start_char int64 | chunk_end_char int64 |
|---|---|---|---|---|---|---|
27caf357-79a1-e9b8-5005-28aaa18faaa4::0 | Following a cerebral ischemic event, substantial alterations in both cellular and molecular activities occur due to ischemia-induced cerebral pathology. Mounting evidence indicates that the robust recruitment of immune cells plays a central role in the acute stage of stroke. Infiltrating peripheral immune cells and res... | 27caf357-79a1-e9b8-5005-28aaa18faaa4 | The Role of Immune Cells in Post-Stroke Angiogenesis and Neuronal Remodeling: The Known and the Unknown | 0 | 0 | 782 |
27caf357-79a1-e9b8-5005-28aaa18faaa4::1 | Neural tissue damage repair processes include angiogenesis, neurogenesis, and synaptic remodeling, etc. Post-stroke inflammatory cells can adopt divergent phenotypes that influence the aforementioned biological processes in both endothelial and neural stem cells by either alleviating acute inflammatory responses or sec... | 27caf357-79a1-e9b8-5005-28aaa18faaa4 | The Role of Immune Cells in Post-Stroke Angiogenesis and Neuronal Remodeling: The Known and the Unknown | 1 | 783 | 1,450 |
27caf357-79a1-e9b8-5005-28aaa18faaa4::2 | A comprehensive understanding of these inflammatory mechanisms may help identify potential targets for the development of novel immunoregulatory therapeutic strategies that ameliorate complications and improve functional rehabilitation after stroke. | 27caf357-79a1-e9b8-5005-28aaa18faaa4 | The Role of Immune Cells in Post-Stroke Angiogenesis and Neuronal Remodeling: The Known and the Unknown | 2 | 1,451 | 1,700 |
b4e3dc06-d990-ad53-927d-8561d8339bb8::0 | Although the knowledge and implementation gaps must be bridged, simply rectifying these inadequacies is insufficient for elimination of TB. Societal resolve and ambition are also required to garner the necessary resources for sustained efforts and effective programs, adapted to local epidemiologic realities. | b4e3dc06-d990-ad53-927d-8561d8339bb8 | Bridging Implementation, Knowledge, and Ambition Gaps to Eliminate Tuberculosis in the United States and Globally | 0 | 0 | 309 |
d41933e3-1f50-1539-541d-25cd16adab8f::0 | In our study we have shown that severity of hepatic fibrosis reflected using biomarkers is independently associated with increased risk of AF, even after adjusting for other traditional cardiac risk factors. With the increasing prevalence of AF in progressive liver disease, even in healthy patients without definite cir... | d41933e3-1f50-1539-541d-25cd16adab8f | The risk of atrial fibrillation in patients with non-alcoholic fatty liver disease and a high hepatic fibrosis index | 0 | 0 | 667 |
06b48efd-d724-9958-5489-59fc008c2b9a::0 | Psychiatric disorders present distinct clinical challenges due to the fact that their diagnosis relies predominantly on observing a patient’s behaviour and on their reporting symptoms rather than on clinical tests for biomarkers. This is mostly attributable to the sheer complexity of psychiatric disorders which are het... | 06b48efd-d724-9958-5489-59fc008c2b9a | Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk | 0 | 0 | 679 |
06b48efd-d724-9958-5489-59fc008c2b9a::1 | Given advances in our understanding of the genetic basis of psychiatric disorders, the question arises whether metrics that describe these, such as the polygenic risk score (PRS), could be used as biomarkers. | 06b48efd-d724-9958-5489-59fc008c2b9a | Potential use of clinical polygenic risk scores in psychiatry – ethical implications and communicating high polygenic risk | 1 | 680 | 888 |
03856395-b110-2945-45a6-e5541a0b8766::0 | There was no strong evidence for bias due to horizontal pleiotropy in the IVW estimates across the analyses. The Egger intercept did not support pleiotropy influencing the IVW estimate, other than for the assessment of the causal influence of depressed affect on anxiety disorders. In all analyses, estimates of the GSMR... | 03856395-b110-2945-45a6-e5541a0b8766 | Understanding the nature of association between anxiety phenotypes and anorexia nervosa: a triangulation approach | 0 | 0 | 570 |
fff35c9b-83ab-0ab7-b8cc-e04d93f585e1::0 | HS is unique compared to other chronic dermatological conditions due to its propensity for skin lesions that involve deeper layers of skin and of largely intimate body areas. This highlights the need for an independent investigation into the barriers to teledermatology for HS. | fff35c9b-83ab-0ab7-b8cc-e04d93f585e1 | Dermatologists’ Perceptions of the Use of Teledermatology in Managing Hidradenitis Suppurativa: Survey Study | 0 | 0 | 277 |
a71acf71-ad1f-3d84-9279-91568ad3f887::0 | Annotation of the identified methylated regions revealed a significant clustering of DNA methylation in gene-associated compartments of the genome in both the cancer and normal cells, and in regions found to be hypermethylated in the cancer cells. We identified numerous 5' gene upstream regions that were methylated in ... | a71acf71-ad1f-3d84-9279-91568ad3f887 | Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences | 0 | 0 | 666 |
a71acf71-ad1f-3d84-9279-91568ad3f887::1 | Two of these regions were confirmed to be novel biomarkers for prostate cancer in an independent set of prostate cancer cell lines and prostate cancer tissues. | a71acf71-ad1f-3d84-9279-91568ad3f887 | Chromosome-wide mapping of DNA methylation patterns in normal and malignant prostate cells reveals pervasive methylation of gene-associated and conserved intergenic sequences | 1 | 667 | 826 |
37fd0389-6333-e86f-7f5d-18dee11b3b55::0 | Perioperative blood transfusion is a strong predictor of poor survival after radical hepatectomy for HCCA. We suggest that circumvention of perioperative blood transfusion can play an important role in long-term survival for patients with HCCA. | 37fd0389-6333-e86f-7f5d-18dee11b3b55 | Perioperative Blood Transfusion as a Poor Prognostic Factor After Aggressive Surgical Resection for Hilar Cholangiocarcinoma | 0 | 0 | 244 |
a893f4c5-a4cc-538d-ba13-ff4b7d0b0f22::0 | It is known that having a psychiatric disorder can have an effect on the brain. Studies investigating schizophrenia and major depression show alterations in brain structure that are present in those with the disorder, but differ from those that are unaffected but at high-risk, indicating that these differences are a co... | a893f4c5-a4cc-538d-ba13-ff4b7d0b0f22 | Social cognition in children at familial high-risk of developing an eating disorder | 0 | 0 | 672 |
e634ab51-aae9-0197-23e0-dbecf6669664::0 | We examined lithium levels in the drinking water of the 274 municipalities of Kyushu Island in Japan and compared these with the crime rates in each municipality. | e634ab51-aae9-0197-23e0-dbecf6669664 | Lithium in drinking water and crime rates in Japan: cross-sectional study | 0 | 0 | 162 |
792a74ef-d597-fa53-c073-a3eebe7a3f02::0 | OncoDB is a comprehensive online database to analyze gene expression and methylation data from over 10 000 patients spanning 33 major cancer types. Researchers could conveniently retrieve and analyze a large quantity of cancer data without requiring advanced bioinformatics skills. In OncoDB, RNA-seq, DNA methylation, a... | 792a74ef-d597-fa53-c073-a3eebe7a3f02 | OncoDB: an interactive online database for analysis of gene expression and viral infection in cancer | 0 | 0 | 418 |
792a74ef-d597-fa53-c073-a3eebe7a3f02::1 | Another unique feature of OncoDB is its oncovirus analysis module, which was developed by integration of viral infection status with cancer genomic and clinical data; this new feature provides functional as well as clinical insights into the roles of oncoviruses in cancer development and progression. | 792a74ef-d597-fa53-c073-a3eebe7a3f02 | OncoDB: an interactive online database for analysis of gene expression and viral infection in cancer | 1 | 419 | 720 |
0d38f3b0-e95e-c748-a234-63a3a45399c8::0 | Intraoral devices have increasingly assumed a key role in the treatment of obstructive sleep apnea syndrome, but there are limitations to their indication and side effects that result from their continuous use, as well as the use of the continuous positive airway pressure device. | 0d38f3b0-e95e-c748-a234-63a3a45399c8 | Side effects of intraoral devices for OSAS treatment Efeitos colaterais dos aparelhos intraorais para tratamento da SAOS | 0 | 0 | 280 |
425d5602-dbbe-d013-7a3b-67e12769f872::0 | When all three classifications are compared, it is clear that some similarities exist based on descriptions. It is necessary to remember that all those classifications were arbitrarily chosen by morphology assessment. Because of the lack of physiopathological studies, these types might not be different. For example, a ... | 425d5602-dbbe-d013-7a3b-67e12769f872 | Posterior Malleolar Fracture Assessment: An Independent Interobserver and Intraobserver Validation of Three Computed Tomography-Based Classifications | 0 | 0 | 626 |
33b2e829-c77c-3c03-1749-df931fcb1f0a::0 | People who attend day centres may be at increased risk of experiencing mental illness-related stigma. Their attendance at the centre makes it more difficult to conceal their diagnosis and may be itself associated with stigma independent of a diagnosis of mental illness. This population have been traditionally neglected... | 33b2e829-c77c-3c03-1749-df931fcb1f0a | Risk factors associated with experienced stigma among people diagnosed with mental ill-health: a cross-sectional study | 0 | 0 | 506 |
7f46ac82-ca83-2b0e-dae9-38a73dc99196::0 | Recovery after stroke is complex phenomenon. Many interventions have been developed to support the poststroke recovery and an increasing number of randomized controlled trials and systematic reviews are in progress. Spontaneous neuroplasticity triggered after stroke by behavioral demand of coordinated movements and the... | 7f46ac82-ca83-2b0e-dae9-38a73dc99196 | Influence of Inflammation on Poststroke Plasticity | 0 | 0 | 682 |
7f46ac82-ca83-2b0e-dae9-38a73dc99196::1 | Since postischemic inflammation is associated not only with ischemic damage but also with the repair of injured brain tissue, the most important aspect of therapies targeting the immune system will be to regulate the balance between the neurotoxic and neuroprotective effects of inflammatory state components. | 7f46ac82-ca83-2b0e-dae9-38a73dc99196 | Influence of Inflammation on Poststroke Plasticity | 1 | 683 | 992 |
d35cb082-bf49-200e-c646-5af4bebd961b::0 | A sample of 100 caregivers of persons with severe burns injury were administered questionnaires to assess their depression, anxiety, social support and quality of life. Findings show that depression and anxiety were negatively correlated with quality of life whereas social support was positively correlated with quality... | d35cb082-bf49-200e-c646-5af4bebd961b | Mediation effects of depression and anxiety on social support and quality of life among caregivers of persons with severe burns injury | 0 | 0 | 649 |
baf5ee51-7431-84d7-538d-b9cbe175e2ba::0 | The regression analysis showed that participants with higher levels of frustration towards farm work had a 2% higher probability of exhibiting mental disorders. A study on the global assessment of the environmental and socioeconomic impacts of drought on agricultural workers showed that drought was associated with incr... | baf5ee51-7431-84d7-538d-b9cbe175e2ba | Mental and Physical Symptoms of Female Rural Workers: Relation between Household and Rural Work | 0 | 0 | 655 |
baf5ee51-7431-84d7-538d-b9cbe175e2ba::1 | With regard to the participants in the present study, it is not possible to assert that their frustrations toward agricultural work were caused by drought, but regardless of the reasons for their frustration, the impacts of drought are quickly felt and impose a greater workload, which increases physical discomfort and ... | baf5ee51-7431-84d7-538d-b9cbe175e2ba | Mental and Physical Symptoms of Female Rural Workers: Relation between Household and Rural Work | 1 | 656 | 1,274 |
cae9ac58-9efd-c978-839a-c463d6a1d07b::0 | BQ showed an acceptable reliability after excluding the questions Has anyone noticed that you stop breathing during your sleep? and Have you ever dozed off or fallen asleep while driving?. This should be tested in further studies with samples mostly comprised of women and low educational level individuals. Given the bu... | cae9ac58-9efd-c978-839a-c463d6a1d07b | Prevalence of Risk for Obstructive Sleep Apnea Syndrome and Association With Risk Factors in Primary Care | 0 | 0 | 449 |
e4bd12f9-b5c6-5873-ff71-7e1faa356d28::0 | The aim of this in vitro study was to test the whitening effect of a newly developed gel formulation based on microcrystalline HAP. To exclude any abrasive influence by toothpaste abrasives harder than natural enamel, 20 and more importantly by the toothbrush that is used in daily oral care, this HAP-gel formulation do... | e4bd12f9-b5c6-5873-ff71-7e1faa356d28 | In Vitro Whitening Effect of a Hydroxyapatite-Based Oral Care Gel | 0 | 0 | 581 |
e4bd12f9-b5c6-5873-ff71-7e1faa356d28::1 | 1 The assumed mode of action of the newly developed whitening formulation with HAP is based on its adhesion of particles on the enamel surface. | e4bd12f9-b5c6-5873-ff71-7e1faa356d28 | In Vitro Whitening Effect of a Hydroxyapatite-Based Oral Care Gel | 1 | 582 | 725 |
1d93cbc6-9104-ca0a-596e-b37f060e21f7::0 | The questions of what the embryo is constituted of at fertilization and how it is shaped during development are major subjects of study in developmental biology. Research in this field is bringing important insight into epigenetic inheritance. For instance, the recognition that gene transcription supports the establish... | 1d93cbc6-9104-ca0a-596e-b37f060e21f7 | Epigenetic Inheritance: Impact for Biology and Society—recent progress, current questions and future challenges | 0 | 0 | 751 |
aa9164cd-01a2-1594-4882-f84755918eed::0 | Patients with sinistral portal hypertension frequently form varices most commonly in the fundus of the stomach. This location is explained by the venous drainage of the spleen via the short gastric veins. In contrast, gastric and oesophageal varices are more commonly precipitated by hepatic sinusoidal hypertension, but... | aa9164cd-01a2-1594-4882-f84755918eed | Iatrogenic Sinistral Hypertension Complicating Screening Colonoscopy | 0 | 0 | 652 |
aa9164cd-01a2-1594-4882-f84755918eed::1 | This complication has not been described previously to our knowledge. | aa9164cd-01a2-1594-4882-f84755918eed | Iatrogenic Sinistral Hypertension Complicating Screening Colonoscopy | 1 | 653 | 722 |
d3474036-e6f8-82a9-6876-5cf3d61884d8::0 | Thus, by implementing multiple DE and clustering packages BingleSeq enables users to explore and pick the method that is most suitable for their experiment. | d3474036-e6f8-82a9-6876-5cf3d61884d8 | BingleSeq: a user-friendly R package for bulk and single-cell RNA-Seq data analysis | 0 | 0 | 156 |
94b483f2-af5d-a1b4-e775-c4cefd069900::0 | This study defines three distinct and common anatomic subgroups of posterior malleolar fragments and defines the average trajectory angle for ideal posterior to anterior lag screw fixation of these subgroups. The use of CT imaging in intraarticular ankle fractures and specifically in posterior malleolar fractures can i... | 94b483f2-af5d-a1b4-e775-c4cefd069900 | Preoperative planning and surgical technique for optimizing internal fixation of posterior malleolar fractures: CT versus standard radiographs | 0 | 0 | 680 |
8e131e90-2c0c-1cec-c84b-c099c69736d1::0 | Splinting decreased the magnitude of stress and strain in teeth close to the center of splint and increased the stress and strain in teeth far from the center of splint. Adequate bone support of canine teeth must be ensured prior to selection of splinting as the treatment plan for the anterior mandible since it increas... | 8e131e90-2c0c-1cec-c84b-c099c69736d1 | Comparison of stress and strain distribution around splinted and non-splinted teeth with compromised periodontium: A three-dimensional finite element analysis | 0 | 0 | 354 |
be2e1318-8a7a-2d20-b1f5-09405408084b::0 | Neuropsychological assessment is central to the diagnosis of dementia and identifying individuals who may be in a prodromal phase of AD. People with MCI have a ten-fold higher risk of progressing to dementia every year than people of the same age in the general population. Thus, many people with MCI are actually in a p... | be2e1318-8a7a-2d20-b1f5-09405408084b | Neuropsychological Measures that Predict Progression from Mild Cognitive Impairment to Alzheimer's type dementia in Older Adults: a Systematic Review and Meta-Analysis | 0 | 0 | 653 |
be2e1318-8a7a-2d20-b1f5-09405408084b::1 | There is a critical need for a systematic analysis of this literature because of the large number of cognitive dimensions that can be measured and because each domain can be assessed with still a larger number of neuropsychological tools. | be2e1318-8a7a-2d20-b1f5-09405408084b | Neuropsychological Measures that Predict Progression from Mild Cognitive Impairment to Alzheimer's type dementia in Older Adults: a Systematic Review and Meta-Analysis | 1 | 654 | 892 |
f75a89a3-1583-a3fd-cc80-57901ce462ee::0 | We demonstrate that fracture care by plate osteosynthesis in multiple trauma patients is significantly associated with the formation of symptomatic heterotopic ossifications. We also found intramedullary nails being associated with a higher incidence of HO remote to the fracture site. Since HO was shown to lead to cons... | f75a89a3-1583-a3fd-cc80-57901ce462ee | Risk of symptomatic heterotopic ossification following plate osteosynthesis in multiple trauma patients: an analysis in a level-1 trauma centre | 0 | 0 | 593 |
b6de1630-123d-650d-82e8-3d5c13d1561d::0 | ASPECTS could be useful to early identify patients requiring DH after EVT for acute large vessel occlusion. | b6de1630-123d-650d-82e8-3d5c13d1561d | Early computed tomography-based scores to predict decompressive hemicraniectomy after endovascular therapy in acute ischemic stroke | 0 | 0 | 107 |
205121eb-22e0-8f01-52cd-356c3b18ad4b::0 | Experimental Condition 1 (EC1): A presentation on mental illness related stigma which included the social and personal impacts of stigma against people with mental illness together with personal testimonies from a mental health service user and a caregiver of a person with mental illness. | 205121eb-22e0-8f01-52cd-356c3b18ad4b | A controlled trial of mental illness related stigma training for medical students | 0 | 0 | 289 |
90c1bc72-1b98-b73f-b9fb-57c10711cead::0 | Understanding the associations of COPD hospitalizations with ambient environmental factors, and how the associations are modified by age and sex are paramount in devising health care guidance and policies, relieving the burden on patients and healthcare systems. Therefore, this study aims to evaluate the nonlinear and ... | 90c1bc72-1b98-b73f-b9fb-57c10711cead | The short-term associations of chronic obstructive pulmonary disease hospitalizations with meteorological factors and air pollutants in Southwest China: a time-series study | 0 | 0 | 546 |
90c1bc72-1b98-b73f-b9fb-57c10711cead::1 | To the best of the authors’ knowledge, this is the first study to explore DLNM in investigating COPD disease for the large inland city in China that also considers the modified effects of sex and age. | 90c1bc72-1b98-b73f-b9fb-57c10711cead | The short-term associations of chronic obstructive pulmonary disease hospitalizations with meteorological factors and air pollutants in Southwest China: a time-series study | 1 | 547 | 747 |
1c03b693-2428-aea4-64c0-03478bd4b64d::0 | In summary, this study showed that single and repeated ketamine infusions reduced SI in individuals with TRD, with cumulative effects observed with thrice-weekly repeated infusions, and maintenance of the effects of ketamine on SI with once-weekly infusions. Current treatment options for SI are limited and these findin... | 1c03b693-2428-aea4-64c0-03478bd4b64d | Single and repeated ketamine infusions for reduction of suicidal ideation in treatment-resistant depression | 0 | 0 | 665 |
1c03b693-2428-aea4-64c0-03478bd4b64d::1 | How long the antisuicidal effects of repeated ketamine infusions last, and whether ketamine-induced reduction in SI can be maintained with alternate pharmacological strategies remains unknown. Moreover, further research is required to determine whether reductions in SI following ketamine treatment translate into decrea... | 1c03b693-2428-aea4-64c0-03478bd4b64d | Single and repeated ketamine infusions for reduction of suicidal ideation in treatment-resistant depression | 1 | 666 | 1,038 |
9c7d324c-405e-66bc-2e74-ebc027467468::0 | Because this study is one of the few that have gathered together such a large number of Fabry patients and because upper lid blood vessels tortuosity was observed in over 90% of these subjects, we are extremely confident in proposing this clinical feature as a characteristic of the disease. | 9c7d324c-405e-66bc-2e74-ebc027467468 | Vascular Tortuosities of the Upper Eyelid: A New Clinical Finding in Fabry Patient Screening | 0 | 0 | 291 |
28e57c08-d010-d888-3b6e-7e07bf02fbc2::0 | These results highlight issues with restricting DNAm-transcript annotations to small genomic intervals and
question the validity of assuming a cis DNAm–GE pathway. | 28e57c08-d010-d888-3b6e-7e07bf02fbc2 | Large-scale integration of DNA methylation and gene expression array platforms identifies both cis and trans relationships | 0 | 0 | 164 |
32f91cd7-d907-f0c9-541e-b156e75e23ad::0 | We also found that the activation of a pathway (as measured by gene signature score) is mostly independent of the circRNAs within the pathway, but less so when looking at relative expression. These instances, for which the relative expression either positively or negatively correlates with the pathway expression, might... | 32f91cd7-d907-f0c9-541e-b156e75e23ad | Back-Splicing Transcript Isoforms (Circular RNAs) Affect Biologically Relevant Pathways and Offer an Additional Layer of Information to Stratify NMIBC Patients | 0 | 0 | 558 |
32f91cd7-d907-f0c9-541e-b156e75e23ad::1 | With a positive correlation there may be a cis-acting role on the pathways, since their relative expression increases with pathway activity but is not bound to the expression of the parental gene. The way by which these circRNAs potentially interact with pathways of interest cannot be directly deduced from this analysi... | 32f91cd7-d907-f0c9-541e-b156e75e23ad | Back-Splicing Transcript Isoforms (Circular RNAs) Affect Biologically Relevant Pathways and Offer an Additional Layer of Information to Stratify NMIBC Patients | 1 | 559 | 987 |
dc1f3b29-4247-0c4c-a57e-f03b8be8e327::0 | These results suggest that natural selection has, at least partially, a role in shaping the genome of Valle del Belice sheep and that ROH in the ovine genome may help to detect genomic regions involved in the determinism of traits under selection. | dc1f3b29-4247-0c4c-a57e-f03b8be8e327 | Genome-wide scan for runs of homozygosity identifies potential candidate genes associated with local adaptation in Valle del Belice sheep | 0 | 0 | 247 |
7536c801-5eb8-7a2d-352c-58ec8d3f440d::0 | Finally, mediation analyses revealed that the sphingomyelin metabolism pathway expression change was significantly correlated with percent change in HAM-D scores and that this effect was mediated via increases in mediodorsal thalamus volume. The mediodorsal thalamus is a nucleus within thalamus that is part of the puta... | 7536c801-5eb8-7a2d-352c-58ec8d3f440d | Integrative analysis of lithium treatment associated effects on brain structure and peripheral gene expression reveals novel molecular insights into mechanism of action | 0 | 0 | 534 |
7536c801-5eb8-7a2d-352c-58ec8d3f440d::1 | It has been suggested that sphingomyelin deposition in the hippocampus may be related to major depression and that antidepressant action may involve sphingomyelin/ceramide metabolism. Thus, drugs targeting sphingomyelin metabolism may be useful in bipolar depression. | 7536c801-5eb8-7a2d-352c-58ec8d3f440d | Integrative analysis of lithium treatment associated effects on brain structure and peripheral gene expression reveals novel molecular insights into mechanism of action | 1 | 535 | 802 |
a5022ae9-7293-ae31-6a9d-d4ea10388788::0 | The molecular mechanisms linking NAFLD and MetS are controversial and the association of NAFLD with the main diagnostic criteria of MetS opens the debate as to whether hepatic steatosis is a consequence or a cause of this disease (9). | a5022ae9-7293-ae31-6a9d-d4ea10388788 | The Liver in Children With Metabolic Syndrome | 0 | 0 | 234 |
79b98ad8-d8b8-cad6-f134-bfd51b200032::0 | Perceived rejection plays an important role for mental health and social integration. This study investigated the impact of rejection intensity and rejection sensitivity on social approach behavior. | 79b98ad8-d8b8-cad6-f134-bfd51b200032 | Effects of rejection intensity and rejection sensitivity on social approach behavior in women | 0 | 0 | 198 |
3bc1adca-e93c-0cde-f58e-3b13acb990dd::0 | Safety outcomes were measured by any adverse events or treatment-emergent adverse effects, which were defined in the trials as onset or exacerbation of an adverse event from the first dose of a study medication until a period of time after the last dose (ranging from 70 to 140 days). The NMA league table of adverse eve... | 3bc1adca-e93c-0cde-f58e-3b13acb990dd | Efficacy and Safety of Biologics and Small Molecules for Moderate-to-Severe Hidradenitis Suppurativa: A Systematic Review and Network Meta-Analysis | 0 | 0 | 498 |
e3fa9219-3df9-6506-d655-86f2c349d81e::0 | The literature reports rates between 13 and 39 per cent of pathological neck node metastases in parotid cancer. Neck dissection should be performed in patients with clinical or radiological evidence of nodal disease. | e3fa9219-3df9-6506-d655-86f2c349d81e | Management of Salivary Gland Tumours: United Kingdom National Multidisciplinary Guidelines SALIVARY GLAND TUMOURS: UK GUIDELINES | 0 | 0 | 216 |
be46ec81-4776-e567-c25d-d2c0b3bf283c::0 | The management of pain in Fabry disease is challenging as a result of the unique interplay between a number of factors. Pain in Fabry disease may affect patients from childhood. Novel techniques in detecting small fibre neuropathy are needed, whilst traditional disease modifying treatments have a limited impact on pain... | be46ec81-4776-e567-c25d-d2c0b3bf283c | Review of Mechanisms, Pharmacological Management, Psychosocial Implications, and Holistic Treatment of Pain in Fabry Disease | 0 | 0 | 321 |
3b93f8af-8006-33f2-4a3b-8213bad3ffb2::0 | Two years after the start of treatment, several participants offered positive stories about how they had achieved their recovery goals. For instance, a young man who at the first interview appeared as severely depressed and a bit delusional shared these goals and hopes with the interviewer during the first interview: | 3b93f8af-8006-33f2-4a3b-8213bad3ffb2 | Experiences of support in working toward personal recovery goals: a collaborative, qualitative study | 0 | 0 | 318 |
4920812f-6f6f-a1b5-6398-95572edd4b9f::0 | Having poor social support also demonstrated a significant association with a poor QoL in the general health domain and psychological domain of QoL. In a study conducted in Japan among pregnant women, social support during pregnancy was considered a necessary factor in the health and well-being of mothers. It concluded... | 4920812f-6f6f-a1b5-6398-95572edd4b9f | Depression and quality of life among pregnant women in first and third trimesters in Abeokuta: A comparative study | 0 | 0 | 601 |
4920812f-6f6f-a1b5-6398-95572edd4b9f::1 | In a study among menopausal women in South Korea, women who were younger at their first delivery and who had more deliveries were noted to be at increased risk of health-related QoL problems after menopause. Furthermore, having an unplanned pregnancy also revealed a significant relationship with poor QoL in the psychol... | 4920812f-6f6f-a1b5-6398-95572edd4b9f | Depression and quality of life among pregnant women in first and third trimesters in Abeokuta: A comparative study | 1 | 602 | 1,272 |
08a7bf4c-302e-4738-f497-dda0af51dff7::0 | Trained female Congolese interviewers verbally administered a quantitative survey after obtaining verbal informed consent. | 08a7bf4c-302e-4738-f497-dda0af51dff7 | Respondent-driven sampling to assess mental health outcomes, stigma and acceptance among women raising children born from sexual violence-related pregnancies in eastern Democratic Republic of Congo | 0 | 0 | 122 |
fb067458-9cad-ec1c-a298-f97c1dd5e287::0 | In the liver, we observed a significant decrease in dnmt1 transcription in males and females, including at environmentally relevant concentrations, demonstrating the very significant impact of BPA on the expression of this key DNA methylation maintenance enzyme. In addition, we report significant hypermethylation of th... | fb067458-9cad-ec1c-a298-f97c1dd5e287 | Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio) EPIGENETICS | 0 | 0 | 590 |
fb067458-9cad-ec1c-a298-f97c1dd5e287::1 | However, this could not be measured in the liver due to technical limitations related to the amount of DNA obtained from this tissue. The fact that changes in the transcript and methylation profile for dnmt1 occur at environmentally relevant concentrations highlights the potential for BPA to cause epigenetic effects in... | fb067458-9cad-ec1c-a298-f97c1dd5e287 | Bisphenol A causes reproductive toxicity, decreases dnmt1 transcription, and reduces global DNA methylation in breeding zebrafish (Danio rerio) EPIGENETICS | 1 | 591 | 964 |
0bd9bb0b-1aae-53a9-6f72-db09bfc69b27::0 | It was assumed that patients with PTSD show stronger negative emotions and cognitions related to one’s own body and suffer more from acute dissociative symptoms than HCs when being confronted with their mirrored body. Finally, the course of specific emotions during the mirror confrontation in patients with PTSD was exp... | 0bd9bb0b-1aae-53a9-6f72-db09bfc69b27 | Standardized mirror confrontation: Body-related emotions, cognitions and level of dissociation in patients with Posttraumatic Stress Disorder after childhood sexual abuse | 0 | 0 | 326 |
5c2a7d5c-1f7d-7ac7-b680-bee345cefc53::0 | For instance, it is known that disruptions in the development of DA circuitry perinatally can contribute to the symptomatology of various psychiatric disorders, such as schizophrenia, that appear later in life. | 5c2a7d5c-1f7d-7ac7-b680-bee345cefc53 | Role of netrin-1 in the organization and function of the mesocorticolimbic dopamine system | 0 | 0 | 210 |
9a0d92ab-6c27-be92-b622-915e1f4b6543::0 | Since there was no non-intervention group in our study it is impossible to say whether the dietary measures directly contributed to the improvement in cough quality of life. Chronic cough may follow a waxing and waning course [31] and it is possible that the improvement in cough score may be explicable by regression to... | 9a0d92ab-6c27-be92-b622-915e1f4b6543 | Dietary intervention in the treatment of patients with cough and symptoms suggestive of airways reflux as determined by Hull airways Reflux Questionnaire | 0 | 0 | 614 |
2271fee0-2a11-1709-4e46-9191ec817a4d::0 | Older patients with OSA have an increased risk of liver injury and NAFLD, and sleep apnea and high TG are important factors in contributing to the development of liver injury. | 2271fee0-2a11-1709-4e46-9191ec817a4d | Relationship between Obstructive Sleep Apnea and Liver Abnormalities in Older Patients: A Cross-Sectional Study | 0 | 0 | 175 |
d9ca6e1d-e999-f155-0c23-7c55ccf63930::0 | Recent studies in patients with coeliac disease have reported an increase in the relative amounts of gram negative bacterial genera such as Bacteroides, Prevotella, and Escherichia, and reduced amounts of protective anti-inflammatory bacteria such as Bifidobacteria and Lactobacilli. Dysbiotic microbiota may lead to a d... | d9ca6e1d-e999-f155-0c23-7c55ccf63930 | Role of the gut microbiota in the pathogenesis of coeliac disease and potential therapeutic implications | 0 | 0 | 606 |
677b2a7e-e525-2e85-a059-d2203671a46a::0 | The analysis revealed just one familial HSCR case carrying a rare variant in one of the genes, but showing no segregation with the phenotype since it was not present in the other affected member of the family and it had been inherited from his unaffected mother. The remaining variants were identified in sporadic HSCR c... | 677b2a7e-e525-2e85-a059-d2203671a46a | Overexpression of DNMT3b target genes during Enteric Nervous System development contribute to the onset of Hirschsprung disease | 0 | 0 | 617 |
677b2a7e-e525-2e85-a059-d2203671a46a::1 | One of them was a female L-HSCR patient carrying both variants in two different genes, SULF1 and CDK5RAP2, while the other one was a male S-HSCR patient with two different rare variants in CDK5RAP2. | 677b2a7e-e525-2e85-a059-d2203671a46a | Overexpression of DNMT3b target genes during Enteric Nervous System development contribute to the onset of Hirschsprung disease | 1 | 618 | 816 |
8f034c26-391d-5ca5-555a-bf8bd8600c12::0 | Intractable epistaxis remains a challenge for otolaryngologists. Historically, internal maxillary artery ligation via a transantral approach and ligation of the ethmoidal vessels and the external carotid artery have been the treatment of choice when conservative management failed. | 8f034c26-391d-5ca5-555a-bf8bd8600c12 | Endoscopic Cauterization of the Sphenopalatine Artery to Control Severe and Recurrent Posterior Epistaxis | 0 | 0 | 281 |
3feef4dc-45fa-0a40-d388-690b5f9c8a5d::0 | Using the experiment results on the accuracy of the integration methods we used on all possible combinations of the omics data types of the cancers, we further analyzed the influence of different omics data on the effectiveness of data integration in cancer subtyping. Moreover, to understand the inconsistency of the re... | 3feef4dc-45fa-0a40-d388-690b5f9c8a5d | Evaluation and comparison of multi-omics data integration methods for cancer subtyping | 0 | 0 | 765 |
f0759d45-d53d-0fd8-19c3-2dba71243f08::0 | Another thoughtful evaluation to be done is regarding the position of the roots of the upper incisors after alignment and leveling so as to place them for good incisal guidance [19]. The slope of the palatal plate should be evaluated as the change in inclination may end up contacting the palatal cortical plate and henc... | f0759d45-d53d-0fd8-19c3-2dba71243f08 | Sagittal Positional Changes of the Mandible Following Alignment and Levelling of Class II Division 2 Cases: An Observational Study in Decelerating Stages of Adolescent Growth Spurt | 0 | 0 | 356 |
76623cee-6ae3-358e-bbc2-135d9d342fe8::0 | However, these targeted studies also highlight the difficulty in finding genomic markers for a disease since the whole-exome analysis can identify more than 200,000 variants and some of these SNPs belong to genes that are not completely characterized. Therefore, the analysis of a high number of significant genetic vari... | 76623cee-6ae3-358e-bbc2-135d9d342fe8 | Tendon and multiomics: advantages, advances, and opportunities | 0 | 0 | 603 |
3f77be6e-37c5-9935-0922-fb65409288c6::0 | If the fracture type and localization allow intramedullary fixation, we prefer this technique due to biomechanical advantages and the possibility of a less invasive approach. Intramedullary nailing has become an established treatment option for many kinds of fractures. In our previous study we presented a new intramedu... | 3f77be6e-37c5-9935-0922-fb65409288c6 | Nailing vs. plating in comminuted proximal ulna fractures – a biomechanical analysis | 0 | 0 | 650 |
3f77be6e-37c5-9935-0922-fb65409288c6::1 | In comminuted fractures the nail can be used as a bridging construction possibly combined with a closed reduction technique, which supports callus formation and secondary bone healing. The results of this study showed sufficient biomechanical results under laboratory conditions for the new implant also in highly unstab... | 3f77be6e-37c5-9935-0922-fb65409288c6 | Nailing vs. plating in comminuted proximal ulna fractures – a biomechanical analysis | 1 | 651 | 1,379 |
38770896-027c-8fa8-e22b-8bcf4a57b26b::0 | We assessed AHI and intensity of snoring pre- and postoperatively through prospective investigation in class III malocclusion patients scheduled to have bimaxillary surgery, and found that the prevalence of newly developed snoring was 27.2% and OSA was 13.6% following surgery. Our findings indicate that dentofacial rep... | 38770896-027c-8fa8-e22b-8bcf4a57b26b | The structural changes of upper airway and newly developed sleep breathing disorders after surgical treatment in class III malocclusion subjects | 0 | 0 | 588 |
41fb366d-d7b8-b933-8db0-319830297d28::0 | To avoid unexpected short- to midterm complications it is of vital importance to evaluate the results of a newly introduced TKA system at an early stage. Therefore, the aim of this study was the evaluation of radiographic short-term results and their influence on implant-survivorship. To our knowledge, this is the firs... | 41fb366d-d7b8-b933-8db0-319830297d28 | Modern cemented total knee arthroplasty design shows a higher incidence of radiolucent lines compared to its predecessor | 0 | 0 | 586 |
106781f9-bfe2-4791-8d08-5118d33cd0e6::0 | Genetic mitochondrial diseases represent a significant challenge to human health. These diseases are extraordinarily heterogeneous in clinical presentation and genetic origin, and often involve multi-system disease with severe progressive symptoms. Mitochondrial diseases represent the most common cause of inherited met... | 106781f9-bfe2-4791-8d08-5118d33cd0e6 | The immune system as a driver of mitochondrial disease pathogenesis: a review of evidence | 0 | 0 | 619 |
2175f9ae-63d6-ed2d-ae07-5b1743a70ad0::0 | There was a strong association between some of our clinical parameters (more specifically point tenderness) and radiographic OA in the tender joint; RC OA (SLAC) wrist and tenderness over the anatomical snuff box, thumb CMC joint tenderness, and OA in the CMC joint, as well as an association between radial sided wrist ... | 2175f9ae-63d6-ed2d-ae07-5b1743a70ad0 | Osteoarthritis of the Wrist STT Joint and Radiocarpal Joint | 0 | 0 | 540 |
2175f9ae-63d6-ed2d-ae07-5b1743a70ad0::1 | Some patients were tender over the area of the STT joint without evidence of radiographic OA. It could be that pain is elicited before the radiographic signs are apparent, or that it is referred to the STT area from adjacent joints such as the thumb CMC joint. This finding supports the discrepancy between radiographic ... | 2175f9ae-63d6-ed2d-ae07-5b1743a70ad0 | Osteoarthritis of the Wrist STT Joint and Radiocarpal Joint | 1 | 541 | 942 |
1f040aa3-79b7-3651-1677-d1079c252f0b::0 | In conclusion, gut barrier dysfunction and bacterial LPS appear to affect CRC development through an increased inflammatory immune response. Changes in the gut barrier can trigger tumor-related inflammation and immune responses while intestinal inflammation promotes gut barrier disruption and increases susceptibility t... | 1f040aa3-79b7-3651-1677-d1079c252f0b | Gut Barrier Dysfunction and Bacterial Lipopolysaccharides in Colorectal Cancer | 0 | 0 | 692 |
20a6164d-e544-1707-4809-ee1f5dbd505b::0 | We strongly emphasize routine transoral inspection before CPAP treatment and further underline the importance of careful physical ENT examination in OSAS workup. | 20a6164d-e544-1707-4809-ee1f5dbd505b | Sleep apnea: Do not forget to inspect the throat! | 0 | 0 | 161 |
cfedff8b-8942-1b69-12ff-bf15865a2b45::0 | Volumetric syndesmotic incisura measurements have been shown to be accurate in diagnosing traumatic syndesmotic instability. Syndesmotic widening has also been recently demonstrated in PCFD patients in a case-control study with 62 symptomatic PCFD and 29 controls where the authors measured the distal tibiofibular synde... | cfedff8b-8942-1b69-12ff-bf15865a2b45 | Distance mapping and volumetric assessment of the ankle and syndesmotic joints in progressive collapsing foot deformity | 0 | 0 | 406 |
cfedff8b-8942-1b69-12ff-bf15865a2b45::1 | An explanation for syndesmotic widening and possible syndesmotic instability in PCFD patients would be related to persistent and progressively increased stresses in the lateral aspect of the tibiotalar, talofibular and subtalar joints secondary to PTS, sinus tarsi and subfibular impingements, as well as possible valgus... | cfedff8b-8942-1b69-12ff-bf15865a2b45 | Distance mapping and volumetric assessment of the ankle and syndesmotic joints in progressive collapsing foot deformity | 1 | 407 | 984 |
cfedff8b-8942-1b69-12ff-bf15865a2b45::2 | They also demonstrated that the widening was more pronounced when FAO values were between 7 and 9.3%, a range that can be considered as moderate to severe collapse and hindfoot valgus in PCFD patients, since values of FAO in healthy non-PCFD patients being reported as normal when up to 5.2%. The assessments performed i... | cfedff8b-8942-1b69-12ff-bf15865a2b45 | Distance mapping and volumetric assessment of the ankle and syndesmotic joints in progressive collapsing foot deformity | 2 | 985 | 1,403 |
cfedff8b-8942-1b69-12ff-bf15865a2b45::3 | since this study measured distance and volumes throughout the entire imaged extension of the distal tibiofibular syndesmosis, up to 10 cm proximal to the ankle joint, rather than a 2D area assessment performed in a single axial plane image. In our assessment, we did not confirm the initially expected syndesmotic wideni... | cfedff8b-8942-1b69-12ff-bf15865a2b45 | Distance mapping and volumetric assessment of the ankle and syndesmotic joints in progressive collapsing foot deformity | 3 | 1,404 | 1,874 |
cfedff8b-8942-1b69-12ff-bf15865a2b45::4 | A possible explanation for this could be that as the talus plantarflexes inside the mortise, likely secondarily to a loss of bony and ligamentous support related to the PTS, the thinner posterior part of the talus moves to interface with the mortise, explaining the increased averaged distances in the posterior aspect o... | cfedff8b-8942-1b69-12ff-bf15865a2b45 | Distance mapping and volumetric assessment of the ankle and syndesmotic joints in progressive collapsing foot deformity | 4 | 1,875 | 2,247 |
cfedff8b-8942-1b69-12ff-bf15865a2b45::5 | This same talar plantarflexion motion would also allow the distal fibula to rotate internally and displace medially, decreasing width of the mortise and potentially explaining the overall smaller averaged syndesmotic incisura distances observed in PCFD patients when compared to controls. Another possible explanation fo... | cfedff8b-8942-1b69-12ff-bf15865a2b45 | Distance mapping and volumetric assessment of the ankle and syndesmotic joints in progressive collapsing foot deformity | 5 | 2,248 | 2,829 |
cfedff8b-8942-1b69-12ff-bf15865a2b45::6 | In that hypothetical scenario, the resultant effects associated with talar plantarflexion could occur earlier, bringing the narrower part of the talar dome into the mortise, unloading the syndesmosis, allowing distal fibular internal rotation and subsequent decrease in the overall distances between the distal tibia and... | cfedff8b-8942-1b69-12ff-bf15865a2b45 | Distance mapping and volumetric assessment of the ankle and syndesmotic joints in progressive collapsing foot deformity | 6 | 2,830 | 3,287 |
cfedff8b-8942-1b69-12ff-bf15865a2b45::7 | Taken together, our results suggest that syndesmotic widening may be a symptom of more severe later stage PCFD, occurring secondary to chronic lateral stresses associated with sinus tarsi and primarily subfibular impingement. It also suggests that subfibular narrowing/impingement may provide an early marker for subsequ... | cfedff8b-8942-1b69-12ff-bf15865a2b45 | Distance mapping and volumetric assessment of the ankle and syndesmotic joints in progressive collapsing foot deformity | 7 | 3,288 | 3,755 |
978e733a-438a-dc44-58a6-552c90d81a27::0 | There has been a focus on protecting the rights to liberty and equality before the law for mental health patients. The nascent literature on promoting human rights in mental healthcare could mark a way forward beyond the ‘Geneva impasse’ that has dominated public debate in recent years. | 978e733a-438a-dc44-58a6-552c90d81a27 | Human rights promotion and the ‘Geneva impasse’ in mental healthcare: scoping review | 0 | 0 | 287 |
29feaec6-a2f1-6e2d-73f5-1ea06456fb99::0 | The CRASH 2 trial showed that TXA significantly reduces death due to bleeding in trauma patients without any increase in thromboembolic events when given within 3 hours of injury. More recently, the WOMAN trial , showed that TXA significantly reduces death due to bleeding in women with PPH. Once again there was no evid... | 29feaec6-a2f1-6e2d-73f5-1ea06456fb99 | No effect of tranexamic acid on platelet function and thrombin generation (ETAPlaT) in postpartum haemorrhage: a randomised placebo-controlled trial [version 1; peer review: 2 approved] | 0 | 0 | 542 |
36308d53-1b61-e829-5854-5fddb4a84d62::0 | Evidence of distrust towards healthcare professionals and western medicine by family and friends was present in some of the participants’ narrations. These include questioning the authenticity and legitimacy of clinical practice by therapists and doctors and believing that monetary gains were the motivation behind thei... | 36308d53-1b61-e829-5854-5fddb4a84d62 | Perceived mental illness stigma among family and friends of young people with depression and its role in help-seeking: a qualitative inquiry | 0 | 0 | 528 |
0fcd203c-c650-a6df-1f69-4333d9dce86d::0 | It will be necessary to study these constructs in the future to address tomorrow’s health issues. To further investigate and refine our findings, we could conduct a study with an experimental design presenting different scenarios with an increasing and controlled number of parameters to see the precise impact of each p... | 0fcd203c-c650-a6df-1f69-4333d9dce86d | Intolerance of Uncertainty and Attitudes towards Vaccination Impact Vaccinal Decision While Perceived Uncertainty Does Not | 0 | 0 | 519 |
0fcd203c-c650-a6df-1f69-4333d9dce86d::1 | However, if we consider that the decision to get vaccinated is more dependent on traits, then this would appear to be useless and doomed because even if we reduce the level of perceived uncertainty, individuals will continue to make decisions according to their attitudes towards vaccination and their level of IU. A stu... | 0fcd203c-c650-a6df-1f69-4333d9dce86d | Intolerance of Uncertainty and Attitudes towards Vaccination Impact Vaccinal Decision While Perceived Uncertainty Does Not | 1 | 520 | 1,221 |
34976e70-81d7-8c2d-9ddc-523a228ac658::0 | The 10-year cumulative survival rate of the arthroscopic BMS procedures was 82% (95% confidence interval [CI]: 77% to 87%). At 15 years of follow-up, the cumulative survival rate was 82% (95% CI: 76% to 86%). | 34976e70-81d7-8c2d-9ddc-523a228ac658 | Ten-Year Survival Rate of 82% in 262 Cases of Arthroscopic Bone Marrow Stimulation for Osteochondral Lesions of the Talus | 0 | 0 | 208 |
77016f17-e27a-5e96-abd6-8bf874c6a532::0 | Men and women showed distinctive lung function trajectories and associated risk factors. Lower lung function trajectories can be explained by not achieving maximally attainable function at age 18 years and by a function decline from 18 to 26 years. | 77016f17-e27a-5e96-abd6-8bf874c6a532 | Distinctive lung function trajectories from age 10 to 26 years in men and women and associated early life risk factors – a birth cohort study | 0 | 0 | 248 |
61e0a0fe-2b57-dc26-41a4-f9f5b9bc9a28::0 | Overall, the existing data in children with Down syndrome suggest that hypoglossal nerve stimulation is well-tolerated and effective for the treatment of OSA in children with Down syndrome. Future studies are needed to extend these results to children without Down syndrome as well. Additionally, results to date are gen... | 61e0a0fe-2b57-dc26-41a4-f9f5b9bc9a28 | The Hypoglossal Nerve Stimulation as a Novel Therapy for Treating Obstructive Sleep Apnea—A Literature Review | 0 | 0 | 673 |
61e0a0fe-2b57-dc26-41a4-f9f5b9bc9a28::1 | It is possible that in addition to the need to replace the device battery approximately every ten years, there may be a need for interval procedures to adjust leads due to growth in younger children. | 61e0a0fe-2b57-dc26-41a4-f9f5b9bc9a28 | The Hypoglossal Nerve Stimulation as a Novel Therapy for Treating Obstructive Sleep Apnea—A Literature Review | 1 | 674 | 873 |
7a216fcb-1c40-fad2-8f13-d367646e9d81::0 | It can be assumed that with a low population coverage with screening examinations, the incidence rates will not be objective due to the lack of information about abnormal changes in the lungs in the unexamined population. | 7a216fcb-1c40-fad2-8f13-d367646e9d81 | Tuberculosis in the Russian Federation: Prognosis and Epidemiological Models in a Situation After the COVID-19 Pandemic | 0 | 0 | 221 |
ec21f27c-9263-4cc4-52b2-b0cc4af39a49::0 | CT has been the most developed and advanced imaging modality in COPD. While CT imaging has certainly surpassed traditional chest X-ray in allowing for the detection of mild forms of emphysema, CT also allows for precise and quantitative analysis of pathologic patterns while simultaneously providing information regardin... | ec21f27c-9263-4cc4-52b2-b0cc4af39a49 | Role of medical and molecular imaging in COPD | 0 | 0 | 453 |
5de98f70-e2eb-967e-dd03-38d0abfba8b8::0 | The aim of the present article is to demonstrate the different treatment approaches for the correction of SB in a young patient with a complex clinical case, ultimately treated with clear aligners and precision wings. | 5de98f70-e2eb-967e-dd03-38d0abfba8b8 | Scissor Bite in Growing Patients: Case Report Treated with Clear Aligners | 0 | 0 | 217 |
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