Instruction datasets for Benchmark
Collection
28 items • Updated
unprocessed stringlengths 304 1.05k | processed stringlengths 4 1.23k |
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In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Selegiline - induced postural hypote... | <span class="chemical">Selegiline</span> - induced postural hypotension in Parkinson ' s disease : a longitudinal study on the effects of drug withdrawal . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: OBJECTIVES : The United Kingdom Park... | OBJECTIVES : The United Kingdom Parkinson ' s Disease Research Group ( UKPDRG ) trial found an increased mortality in patients with Parkinson ' s disease ( PD ) randomized to receive 10 mg <span class="chemical">selegiline</span> per day and <span class="chemical">L - dopa</span> compared with those taking <span class=... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Recently , we found that therapy wit... | Recently , we found that therapy with <span class="chemical">selegiline</span> and <span class="chemical">L - dopa</span> was associated with selective systolic orthostatic hypotension which was abolished by withdrawal of <span class="chemical">selegiline</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This unwanted effect on postural blo... | This unwanted effect on postural blood pressure was not the result of underlying autonomic failure . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The aims of this study were to confi... | The aims of this study were to confirm our previous findings in a separate cohort of patients and to determine the time course of the cardiovascular consequences of stopping <span class="chemical">selegiline</span> in the expectation that this might shed light on the mechanisms by which the drug causes orthostatic hypo... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: METHODS : The cardiovascular respons... | METHODS : The cardiovascular responses to standing and head - up tilt were studied repeatedly in PD patients receiving <span class="chemical">selegiline</span> and as the drug was withdrawn . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: RESULTS : Head - up tilt caused syst... | RESULTS : Head - up tilt caused systolic orthostatic hypotension which was marked in six of 20 PD patients on <span class="chemical">selegiline</span> , one of whom lost consciousness with unrecordable blood pressures . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A lesser degree of orthostatic hypot... | A lesser degree of orthostatic hypotension occurred with standing . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Orthostatic hypotension was ameliora... | Orthostatic hypotension was ameliorated 4 days after withdrawal of <span class="chemical">selegiline</span> and totally abolished 7 days after discontinuation of the drug . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Stopping selegiline also significant... | Stopping <span class="chemical">selegiline</span> also significantly reduced the supine systolic and diastolic blood pressures consistent with a previously undescribed supine pressor action . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: CONCLUSION : This study confirms our... | CONCLUSION : This study confirms our previous finding that <span class="chemical">selegiline</span> in combination with <span class="chemical">L - dopa</span> is associated with selective orthostatic hypotension . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The possibilities that these cardiov... | The possibilities that these cardiovascular findings might be the result of non - selective inhibition of monoamine oxidase or of <span class="chemical">amphetamine</span> and <span class="chemical">metamphetamine</span> are discussed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Further studies on effects of irriga... | Further studies on effects of irrigation solutions on rat bladders . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Further studies on the effects of ce... | Further studies on the effects of certain irrigating fluids on the rat bladder for 18 hours are reported . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The results have shown that the degr... | The results have shown that the degradation product <span class="chemical">p - choloroaniline</span> is not a significant factor in <span class="chemical">chlorhexidine - digluconate</span> associated erosive cystitis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A high percentage of kanamycin - col... | A high percentage of <span class="chemical">kanamycin</span> - <span class="chemical">colistin</span> and <span class="chemical">povidone - iodine</span> irrigations were associated with erosive cystitis and suggested a possible complication with human usage . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Picloxydine irrigations appeared to ... | <span class="chemical">Picloxydine</span> irrigations appeared to have a lower incidence of erosive cystitis but further studies would have to be performed before it could be recommended for use in urological procedures . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Effects of tetrandrine and fangchino... | Effects of <span class="chemical">tetrandrine</span> and <span class="chemical">fangchinoline</span> on experimental thrombosis in mice and human platelet aggregation . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Tetrandrine ( TET ) and fangchinolin... | <span class="chemical">Tetrandrine</span> ( <span class="chemical">TET</span> ) and <span class="chemical">fangchinoline</span> ( <span class="chemical">FAN</span> ) are two naturally occurring analogues with a <span class="chemical">bisbenzylisoquinoline</span> structure . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The present study was undertaken to ... | The present study was undertaken to investigate the effects of <span class="chemical">TET</span> and <span class="chemical">FAN</span> on the experimental thrombosis induced by collagen plus <span class="chemical">epinephrine</span> ( <span class="chemical">EP</span> ) in mice , and platelet aggregation and blood coagu... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In the in vivo study , the administr... | In the in vivo study , the administration ( 50 mg / kg , i . p . ) of <span class="chemical">TET</span> and <span class="chemical">FAN</span> in mice showed the inhibition of thrombosis by 55 % and 35 % , respectively , while <span class="chemical">acetylsalicylic acid</span> ( <span class="chemical">ASA</span> , 50 mg... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In the vitro human platelet aggregat... | In the vitro human platelet aggregations induced by the agonists used in tests , <span class="chemical">TET</span> and <span class="chemical">FAN</span> showed the inhibitions dose dependently . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In addition , neither TET nor FAN sh... | In addition , neither <span class="chemical">TET</span> nor <span class="chemical">FAN</span> showed any anticoagulation activities in the measurement of the activated partial thromboplastin time ( APTT ) , prothrombin time ( PT ) and thrombin time ( TT ) using human - citrated plasma . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These results suggest that antithrom... | These results suggest that antithrombosis of <span class="chemical">TET</span> and <span class="chemical">FAN</span> in mice may be mainly related to the antiplatelet aggregation activities . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Angioedema due to ACE inhibitors : c... | Angioedema due to <span class="chemical">ACE inhibitors</span> : common and inadequately diagnosed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The estimated incidence of angioedem... | The estimated incidence of angioedema during <span class="chemical">angiotensin - converting enzyme ( ACE ) inhibitor</span> treatment is between 1 and 7 per thousand patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This potentially serious adverse eff... | This potentially serious adverse effect is often preceded by minor manifestations that may serve as a warning . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Cocaine - induced mood disorder : pr... | <span class="chemical">Cocaine</span> - induced mood disorder : prevalence rates and psychiatric symptoms in an outpatient <span class="chemical">cocaine</span> - dependent sample . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This paper attempts to examine and c... | This paper attempts to examine and compare prevalence rates and symptom patterns of DSM substance - induced and other mood disorders . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: 243 cocaine - dependent outpatients ... | 243 <span class="chemical">cocaine</span> - dependent outpatients with <span class="chemical">cocaine</span> - induced mood disorder ( CIMD ) , other mood disorders , or no mood disorder were compared on measures of psychiatric symptoms . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The prevalence rate for CIMD was 12 ... | The prevalence rate for CIMD was 12 % at baseline . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Introduction of the DSM - IV diagnos... | Introduction of the DSM - IV diagnosis of CIMD did not substantially affect rates of the other depressive disorders . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Patients with CIMD had symptom sever... | Patients with CIMD had symptom severity levels between those of patients with and without a mood disorder . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These findings suggest some validity... | These findings suggest some validity for the new DSM - IV diagnosis of CIMD , but also suggest that it requires further specification and replication . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Effect of fucoidan treatment on coll... | Effect of <span class="chemical">fucoidan</span> treatment on collagenase - induced intracerebral hemorrhage in rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Inflammatory cells are postulated to... | Inflammatory cells are postulated to mediate some of the brain damage following ischemic stroke . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Intracerebral hemorrhage is associat... | Intracerebral hemorrhage is associated with more inflammation than ischemic stroke . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We tested the sulfated polysaccharid... | We tested the sulfated polysaccharide <span class="chemical">fucoidan</span> , which has been reported to reduce inflammatory brain damage , in a rat model of intracerebral hemorrhage induced by injection of bacterial collagenase into the caudate nucleus . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Rats were treated with seven day int... | Rats were treated with seven day intravenous infusion of <span class="chemical">fucoidan</span> ( 30 micrograms h - 1 ) or vehicle . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The hematoma was assessed in vivo by... | The hematoma was assessed in vivo by magnetic resonance imaging . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Motor behavior , passive avoidance ,... | Motor behavior , passive avoidance , and skilled forelimb function were tested repeatedly for six weeks . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Fucoidan - treated rats exhibited ev... | <span class="chemical">Fucoidan</span> - treated rats exhibited evidence of impaired blood clotting and hemodilution , had larger hematomas , and tended to have less inflammation in the vicinity of the hematoma after three days . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: They showed significantly more rapid... | They showed significantly more rapid improvement of motor function in the first week following hemorrhage and better memory retention in the passive avoidance test . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Acute white matter edema and eventua... | Acute white matter edema and eventual neuronal loss in the striatum adjacent to the hematoma did not differ between the two groups . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Investigation of more specific anti ... | Investigation of more specific anti - inflammatory agents and hemodiluting agents are warranted in intracerebral hemorrhage . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Recurarization in the recovery room ... | Recurarization in the recovery room . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A case of recurarization in the reco... | A case of recurarization in the recovery room is reported . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Accumulation of atracurium in the in... | Accumulation of <span class="chemical">atracurium</span> in the intravenous line led to recurarization after flushing the line in the recovery room . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A respiratory arrest with severe des... | A respiratory arrest with severe desaturation and bradycardia occurred . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Circumstances leading to this event ... | Circumstances leading to this event and the mechanisms enabling a neuromuscular blockade to occur , following the administration of a small dose of relaxant , are discussed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The haemodynamic effects of propofol... | The haemodynamic effects of <span class="chemical">propofol</span> in combination with <span class="chemical">ephedrine</span> in elderly patients ( ASA groups 3 and 4 ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The marked vasodilator and negative ... | The marked vasodilator and negative inotropic effects of <span class="chemical">propofol</span> are disadvantages in frail elderly patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: We investigated the safety and effic... | We investigated the safety and efficacy of adding different doses of <span class="chemical">ephedrine</span> to <span class="chemical">propofol</span> in order to obtund the hypotensive response . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The haemodynamic effects of adding 1... | The haemodynamic effects of adding 15 , 20 or 25 mg of <span class="chemical">ephedrine</span> to 200 mg of <span class="chemical">propofol</span> were compared to control in 40 ASA 3 / 4 patients over 60 years presenting for genito - urinary surgery . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The addition of ephedrine to propofo... | The addition of <span class="chemical">ephedrine</span> to <span class="chemical">propofol</span> appears to be an effective method of obtunding the hypotensive response to <span class="chemical">propofol</span> at all doses used in this study . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: However , marked tachycardia associa... | However , marked tachycardia associated with the use of <span class="chemical">ephedrine</span> in combination with <span class="chemical">propofol</span> occurred in the majority of patients , occasionally reaching high levels in individual patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Due to the risk of this tachycardia ... | Due to the risk of this tachycardia inducing myocardial ischemia , we would not recommend the use in elderly patients of any of the <span class="chemical">ephedrine</span> / <span class="chemical">propofol</span> / mixtures studied . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Gemcitabine plus vinorelbine in nons... | <span class="chemical">Gemcitabine</span> plus <span class="chemical">vinorelbine</span> in nonsmall cell lung carcinoma patients age 70 years or older or patients who cannot receive <span class="chemical">cisplatin</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Oncopaz Cooperative Group .
### Outp... | Oncopaz Cooperative Group . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: BACKGROUND : Although the prevalence... | BACKGROUND : Although the prevalence of nonsmall cell lung carcinoma ( NSCLC ) is high among elderly patients , few data are available regarding the efficacy and toxicity of chemotherapy in this group of patients . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Recent reports indicate that single ... | Recent reports indicate that single agent therapy with <span class="chemical">vinorelbine</span> ( <span class="chemical">VNB</span> ) or <span class="chemical">gemcitabine</span> ( <span class="chemical">GEM</span> ) may obtain a response rate of 20 - 30 % in elderly patients , with acceptable toxicity and improvement... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In the current study the efficacy an... | In the current study the efficacy and toxicity of the combination of <span class="chemical">GEM</span> and <span class="chemical">VNB</span> in elderly patients with advanced NSCLC or those with some contraindication to receiving <span class="chemical">cisplatin</span> were assessed . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: METHODS : Forty - nine patients with... | METHODS : Forty - nine patients with advanced NSCLC were included , 38 of whom were age > / = 70 years and 11 were age < 70 years but who had some contraindication to receiving <span class="chemical">cisplatin</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: All patients were evaluable for resp... | All patients were evaluable for response and toxicity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Treatment was comprised of VNB , 25 ... | Treatment was comprised of <span class="chemical">VNB</span> , 25 mg / m ( 2 ) , plus <span class="chemical">GEM</span> , 1000 mg / m ( 2 ) , both on Days 1 , 8 , and 15 every 28 days . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Patients received a minimum of three... | Patients received a minimum of three courses unless progressive disease was detected . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: RESULTS : One hundred sixty - five c... | RESULTS : One hundred sixty - five courses were administered , with a median of 3 . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: 6 courses per patient .
### Output T... | 6 courses per patient . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The overall response rate was 26 % (... | The overall response rate was 26 % ( 95 % confidence interval , 15 - 41 % ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Two patients attained a complete res... | Two patients attained a complete response ( 4 % ) and 11 patients ( 22 % ) achieved a partial response . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Eastern Cooperative Oncology Group p... | Eastern Cooperative Oncology Group performance status improved in 35 % of those patients with an initial value > 0 , whereas relief of at least 1 symptom without worsening of other symptoms was noted in 27 patients ( 55 % ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The median time to progression was 1... | The median time to progression was 16 weeks and the 1 - year survival rate was 33 % . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Toxicity was mild .
### Output Text: | Toxicity was mild . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Six patients ( 12 % ) had World Heal... | Six patients ( 12 % ) had World Health Organization Grade 3 - 4 neutropenia , 2 patients ( 4 % ) had Grade 3 - 4 thrombocytopenia , and 2 patients ( 4 % ) had Grade 3 neurotoxicity . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Three patients with severe neutropen... | Three patients with severe neutropenia ( 6 % ) died of sepsis . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The median age of those patients dev... | The median age of those patients developing Grade 3 - 4 neutropenia was significantly higher than that of the remaining patients ( 75 years vs . 72 years ; P = 0 . 047 ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: CONCLUSIONS : The combination of GEM... | CONCLUSIONS : The combination of <span class="chemical">GEM</span> and <span class="chemical">VNB</span> is moderately active and well tolerated except in patients age > / = 75 years . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This age group had an increased risk... | This age group had an increased risk of myelosuppression . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Therefore the prophylactic use of gr... | Therefore the prophylactic use of granulocyte - colony stimulating factor should be considered with this treatment . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: New chemotherapy combinations with h... | New chemotherapy combinations with higher activity and lower toxicity are needed for elderly patients with advanced NSCLC . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: A selective dopamine D4 receptor ant... | A selective <span class="chemical">dopamine</span> D4 receptor antagonist , <span class="chemical">NRA0160</span> : a preclinical neuropharmacological profile . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: NRA0160 , 5 - [ 2 - ( 4 - ( 3 - fluo... | <span class="chemical">NRA0160</span> , <span class="chemical">5 - [ 2 - ( 4 - ( 3 - fluorobenzylidene ) piperidin - 1 - yl ) ethyl ] - 4 - ( 4 - fluorophenyl ) thiazole - 2 - carboxamide</span> , has a high affinity for human cloned <span class="chemical">dopamine</span> D4 . 2 , D4 . 4 and D4 . 7 receptors , with Ki ... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: NRA0160 is over 20 , 000fold more po... | <span class="chemical">NRA0160</span> is over 20 , 000fold more potent at the <span class="chemical">dopamine</span> D4 . 2 receptor compared with the human cloned <span class="chemical">dopamine</span> D2L receptor . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: NRA0160 has negligible affinity for ... | <span class="chemical">NRA0160</span> has negligible affinity for the human cloned <span class="chemical">dopamine</span> D3 receptor ( Ki = 39 nM ) , rat <span class="chemical">serotonin</span> ( <span class="chemical">5 - HT</span> ) 2A receptors ( Ki = 180 nM ) and rat alpha1 adrenoceptor ( Ki = 237 nM ) . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: NRA0160 and clozapine antagonized lo... | <span class="chemical">NRA0160</span> and <span class="chemical">clozapine</span> antagonized locomotor hyperactivity induced by <span class="chemical">methamphetamine</span> ( <span class="chemical">MAP</span> ) in mice . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: NRA0160 and clozapine antagonized MA... | <span class="chemical">NRA0160</span> and <span class="chemical">clozapine</span> antagonized <span class="chemical">MAP</span> - induced stereotyped behavior in mice , although their effects did not exceed 50 % inhibition , even at the highest dose given . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: NRA0160 and clozapine significantly ... | <span class="chemical">NRA0160</span> and <span class="chemical">clozapine</span> significantly induced catalepsy in rats , although their effects did not exceed 50 % induction even at the highest dose given . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: NRA0160 and clozapine significantly ... | <span class="chemical">NRA0160</span> and <span class="chemical">clozapine</span> significantly reversed the disruption of prepulse inhibition ( PPI ) in rats produced by <span class="chemical">apomorphine</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: NRA0160 and clozapine significantly ... | <span class="chemical">NRA0160</span> and <span class="chemical">clozapine</span> significantly shortened the <span class="chemical">phencyclidine</span> ( <span class="chemical">PCP</span> ) - induced prolonged swimming latency in rats in a water maze task . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: These findings suggest that NRA0160 ... | These findings suggest that <span class="chemical">NRA0160</span> may have unique antipsychotic activities without the liability of motor side effects typical of classical antipsychotics . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Warfarin - induced artery calcificat... | <span class="chemical">Warfarin</span> - induced artery calcification is accelerated by growth and <span class="chemical">vitamin D</span> . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The present studies demonstrate that... | The present studies demonstrate that growth and <span class="chemical">vitamin D</span> treatment enhance the extent of artery calcification in rats given sufficient doses of <span class="chemical">Warfarin</span> to inhibit gamma - carboxylation of matrix Gla protein , a calcification inhibitor known to be expressed b... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The first series of experiments exam... | The first series of experiments examined the influence of age and growth status on artery calcification in <span class="chemical">Warfarin</span> - treated rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Treatment for 2 weeks with Warfarin ... | Treatment for 2 weeks with <span class="chemical">Warfarin</span> caused massive focal calcification of the artery media in 20 - day - old rats and less extensive focal calcification in 42 - day - old rats . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: In contrast , no artery calcificatio... | In contrast , no artery calcification could be detected in 10 - month - old adult rats even after 4 weeks of <span class="chemical">Warfarin</span> treatment . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: To directly examine the importance o... | To directly examine the importance of growth to <span class="chemical">Warfarin</span> - induced artery calcification in animals of the same age , 20 - day - old rats were fed for 2 weeks either an ad libitum diet or a 6 - g / d restricted diet that maintains weight but prevents growth . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Concurrent treatment of both dietary... | Concurrent treatment of both dietary groups with <span class="chemical">Warfarin</span> produced massive focal calcification of the artery media in the ad libitum - fed rats but no detectable artery calcification in the restricted - diet , growth - inhibited group . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: Although the explanation for the ass... | Although the explanation for the association between artery calcification and growth status cannot be determined from the present study , there was a relationship between higher serum <span class="chemical">phosphate</span> and susceptibility to artery calcification , with 30 % higher levels of serum <span class="chemi... |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: This observation suggests that incre... | This observation suggests that increased susceptibility to <span class="chemical">Warfarin</span> - induced artery calcification could be related to higher serum <span class="chemical">phosphate</span> levels . |
In the sentence extracted from biomedical literature, identify all the chemical entities. The required answer format is the same sentence with HTML <span> tags to mark up specific entities.
### Entity Markup Guides:
Use <span class="chemical"> to denote a chemical.
### Input Text: The second set of experiments examin... | The second set of experiments examined the possible synergy between <span class="chemical">vitamin D</span> and <span class="chemical">Warfarin</span> in artery calcification . |
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