Split (3)

train · 1k rows

id stringlengths 5 7	query stringlengths 4.64k 8.32k	answer stringlengths 392 2.53k
PLOS100	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Heart disease remains the most common source of mortality in the American population. The Western diet has been implicated as an important factor, though the mechanisms by which high levels of dietary sugar and fat contribute to heart failure remain controversial. Here, we use the fruit fly Drosophila to explore the ro...
PLOS101	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Meiosis is a special type of cell division occurring in germ cells to produce sexual gametes. Initially, germ cells contain two copies of each chromosome, one from the mother and one from the father, which are called homologs. During meiosis, cells divide twice to produce haploid gametes with only one copy of each chro...
PLOS102	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	An important strategy of Yersinia enterocolitica (Ye) to suppress the immune defense is to inject bacterial proteins (Yersinia outer proteins, Yops) after cell contact directly into host cells, which affects their functions. However, tracking of cells in which Yop injection occurred has only been described for Yersinia...
PLOS103	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Dengue viral infections have become one of the most important mosquito borne viral infections in the world and are one of the major emerging infectious diseases. The occurrence of dengue haemorrhagic fever is thought to result from a complex interplay between the virus, host genetics and host immune factors. Patients w...
PLOS104	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Chagas disease is a fatal illness caused by Trypanosoma cruzi parasites, which are transmitted by blood sucking triatomine insect vectors. Although blood is a natural food source for these insects, its digestion releases toxic products, which poses a dietary challenge for both triatomine insects and trypanosomes. To ov...
PLOS105	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Human brucellosis may present with a wide variety of symptoms and signs. Adequate laboratory diagnostic methods become necessary. The diagnostic method that proves infection caused by Brucella spp. is the isolation of the bacteria from body fluids or tissues, but the difficulty in obtaining positive bacterial cultures ...
PLOS106	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Schistosomiasis, a neglected tropical disease, owes its continued success to freshwater snails that support production of prolific numbers of human-infective cercariae. Encounters between schistosomes and snails do not always result in the snail becoming infected, in part because snails can mount immune responses that ...
PLOS107	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Little is known about communication patterns and social relations between health staff and long -term patients in African hospitals. An ethnography of a reference hospital treating patients afflicted with Buruli Ulcer (BU) and other chronic ulcers in Benin was conducted. Sources of psychosocial distress and communicati...
PLOS108	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Studies with rats in the 1930s showed a surprising increase in lifespan when the diet contained 30%–40% fewer calories than normal. This experiment has been repeated on many organisms and is the gold standard for extending lifespan. While we are beginning to understand how calorie restriction regulates lifespan, the me...
PLOS109	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Most human genes have introns that have to be removed after a gene is transcribed from DNA to RNA because they not encode information to translate RNA into proteins. As mutations in introns do not affect protein sequences, they are usually ignored when looking for normal or pathogenic genomic variation. However, intron...
PLOS110	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Perception inevitably depends on combining sensory input with prior expectations. This is particularly critical for identifying degraded input. However, the underlying neural mechanism by which expectations influence sensory processing is unclear. Predictive Coding theories suggest that the brain passes forward the une...
PLOS111	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Cystic echinococcosis (CE) is a parasitic zoonosis prevalent worldwide, especially in economically poor livestock raising areas. Parasitic cysts develop most commonly in the liver and are diagnosed primarily by ultrasound. Serology helps with diagnosis, particularly when ultrasound features are unclear. Unfortunately, ...
PLOS112	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The annual number of new leprosy cases has been stable in the past decade, indicating that transmission has not been yet been interrupted. As current control seems to be insufficient to bring down the number of cases, there is a need for novel tools to interrupt transmission. A diagnostic that permitted diagnosis of su...
PLOS113	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Cholera, which can be a severe watery diarrheal illness caused by the non-invasive bacterium Vibrio cholerae, remains a global public health concern for many developing countries. Immune responses targeting the O-specific polysaccharide (OSP) of V. cholerae are involved in mediating protection against cholera. Evidence...
PLOS114	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Despite considerable scientific advances in plant protection during the last century, agricultural crops remain vulnerable to infection by pathogens. The intensive cultivation particularly of clonally propagated crop plants increases the potential for the emergence and rapid spread of new diseases. Pseudomonas syringae...
PLOS115	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	CRISPR-Cas systems confer to bacteria and archaea an adaptive immunity that protects them against invading bacteriophages and plasmids. In this study, we characterize a CRISPR (RliB-CRISPR) that is present in all L. monocytogenes strains at the same genomic locus but is never associated with a cas operon. It is an unus...
PLOS116	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	One of the recent key innovations in the epidemiology of infectious diseases was the incorporation of explicit contact structure (i.e. who can infect whom) into epidemiological models. Theoretical studies have generated a broad consensus in the field that knowledge of the contact network may help to greatly improve the...
PLOS117	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Allostery is the process whereby a molecule binds to one site in a protein and alters the function of a distant site. This phenomenon is ubiquitous, as proteins frequently must adapt their behavior to changes in the cellular milieu. The mechanism(s) underlying allostery remains incompletely understood. In particular, p...
PLOS118	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Functional connectivity, as reflected in the statistical dependencies of distributed activity, is widely used to probe the organization of complex systems such as the brain. While this measure has been helpful for characterizing brain states and highlighting alterations of brain dynamics in various diseases, the mechan...
PLOS119	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Human bocavirus 1 (HBoV1) has been identified as one of the etiological agents of wheezing in young children with acute respiratory-tract infections. HBoV1 productively infects polarized primary human airway epithelia. However, no cell lines permissive to HBoV1 infection have yet been established. More importantly, the...
PLOS120	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	During development, processes such as cell division, fate determination, migration, and removal of dead cells occur in a directional (i.e., polar) manner. For example, cell divisions in the early embryo often occur in a directional manner to maintain specific cell–cell interactions. Later, during organ formation, tissu...
PLOS121	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Eukaryotic cells require specific arrangements of microtubules to carry out diverse functions, including cell division and intracellular transport. In dividing animal cells, microtubules are arranged radially around two centrosomes, promoting the correct distribution of DNA into daughter cells. As cells differentiate, ...
PLOS122	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	At least 70 million people have been infected with HIV since the beginning of the epidemic and an effective vaccine remains elusive. The high mutation rate and diversity of HIV strains enables the virus to effectively evade host immune responses, presenting a significant challenge for HIV vaccine design. We have develo...
PLOS123	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	To summarize our understanding of how genes, their products and other cellular actors interact with each other, we often employ networks to describe their interactions. However, networks do not fully specify how the underlying biological system behaves in different conditions, nor how such response evolves in time. We ...
PLOS124	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Replication of plus-stranded RNA viruses, which are important pathogens of humans, animals and plants, can be inhibited by host-coded proteins. In this paper, the authors show that the Cyp40-like Cpr7p prolyl isomerase of yeast can effectively inhibit tombusvirus replication. This inhibition is due to binding of the TP...
PLOS125	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Implantation in mammals requires a complex crosstalk between the conceptus (the embryo and associated membranes) and the uterus. An imbalanced regulation of the factors contributing to these interactions has negative impacts on the attachment of the fetus, the progression of the pregnancy, and the progeny. Focusing on ...
PLOS126	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The repeated infection that causes trachoma is spread from person to person via infected ocular and nasal secretions. The World Health Organization (WHO) strategy for trachoma control includes keeping children’s faces clean of discharges, yet “clean faces” are not measured in most of the district surveys that evaluate ...
PLOS127	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The human genome is structurally dynamic, frequently undergoing loss, duplication, and rearrangement of large chromosome segments. These structural changes occur both in normal and in cancerous cells and are thought to cause both benign and deleterious changes in cell function. Many of these structural alterations are ...
PLOS128	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Hox genes encode a conserved family of transcription factors that regulate unique cell types within the distinct morphological structures that arise along the body plan of animals. Hox transcription factors specify different cell fates by regulating the expression of downstream genes, many of which are part of cell sig...
PLOS129	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Social isolation severely affects the behavior and physiology of social animals, including humans. The fruit fly is a powerful model for studying the mechanisms of development, health and disease and is also used to study social behaviors such as mating and aggression. However, these studies are limited to examining fe...
PLOS130	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Onchocerciasis, also known as river blindness is a tropical disease causing health and socioeconomic problems in endemic communities especially sub-Saharan Africa. The disease is transmitted by a filarial nematode called Onchocerca volvulus, which is spread by the bite of infected Simulium black flies. Characteristic d...
PLOS131	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Pathogenic bacteria release a number of different proteins that function to interfere with host defenses and allow bacterial invasion, persistence, and replication in the host. In many bacterial pathogens, the type III secretion system is used to inject these virulence factors directly to the cytoplasm of the host cell...
PLOS132	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	White blood cells (leukocytes) are the effector cells of the immune system. The movement (extravasation) of leukocytes from the bloodstream to the surrounding tissue is a prerequisite for proper host defense. Platelets are anucleate cell particles that circulate in the blood and play a fundamental role in hemostasis. H...
PLOS133	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Lining the airways, brain ventricles, and oviducts, multicilia are small hair-like structures that beat in a whip-like motion to propel fluids, such as mucus, over cell surfaces. Dysfunction of multicilia arising from genetic perturbations is most prominently associated with a devastating disorder called primary ciliar...
PLOS134	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In neurodegenerative diseases, such as Alzheimer's disease and Huntington's disease, specific proteins escape the cell's quality-control system and associate together, forming insoluble aggregates. Until now, little was known about whether proteins aggregate in a non-disease context. In this study, we discovered that t...
PLOS135	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The animal body is protected by physical, chemical and immunological barriers. Identification of “promising” target sites is therefore of importance for any pathogen. This crucial step of the infection is still poorly understood. Here, we have studied target site selection by the flagellated Gram-negative gut pathogen ...
PLOS136	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Prions, which are the cause of fatal neurodegenerative disorders termed transmissible spongiform encephalopathies (TSEs), can be experimentally or naturally transmitted via prion-contaminated food, blood, milk, saliva, feces and urine. Here we demonstrate that prions can be transmitted through aerosols in mice. This al...
PLOS137	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	A. costaricensis is a poorly studied nematode that causes abdominal angiostrongyliasis, a human parasitic disease. Peptidases perform several functions in the life cycle of parasites, including nutrition, differentiation and host invasion. The present study characterized the repertoire of peptidases in A. costaricensis...
PLOS138	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The pathogenic fungus Aspergillus fumigatus causes disease in immunocompromised individuals such as cancer patients. The fungus makes a small molecule called gliotoxin which helps A. fumigatus bypass the immune system in ill people, and cause disease. Although a small molecule, gliotoxin biosynthesis is enabled by a co...
PLOS139	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In Creutzfeldt-Jakob disease (CJD), heterozygosity at residue 129 for methionine or valine in normal prion protein may affect disease phenotype, onset and progression. However, the relative contribution of each prion protein allotype to the infectious, disease associated form of prion protein (PrPSc) is unknown. Here w...
PLOS140	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Child development in early childhood lays a foundation for lifelong learning. Risk and protective factors for child development are known to include many issues faced by children growing up in low- and middle-income countries. Studies indicate a difference between boys and girls in terms of impact of factors influencin...
PLOS141	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Gene expression is a fundamental cellular process that contributes to phenotypic diversity. Gene expression can vary between alleles of an individual through differences in genomic imprinting or cis-acting regulatory variation. Distinguishing allelic activity is important for informing the abundance of altered mRNA and...
PLOS142	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	As fungi-attributed human deaths are increasing, there is an urgent need to develop new antifungal treatments. Two-component related proteins, such as the Ypd1 phosphorelay protein, have been heralded as antifungal targets as they are not found in humans and because inactivation of YPD1 in several different fungi cause...
PLOS143	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Myxoma virus (MYXV), a rabbit-specific poxvirus pathogen, encodes diverse immunomodulatory proteins that can collectively overcome essentially all of the host immune defenses. MYXV-encoded protein M013, a member of the cellular PYRIN domain-containing superfamily of proteins, was previously shown to be important for vi...
PLOS144	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The canid adapted intestinal tapeworms, Echinococcus granulosus, E. multilocularis and E. shuiqucus are well known to be endemic in Northwestern China. The first two species can cause fatal disease in humans. Although E. shiquicus has not been reported to infect humans, all three species can be transmitted by dogs. The...
PLOS145	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Genome-Wide Association Studies (GWAS) can reveal genetic-phenotypic relationships, but have limitations. To control false positives, population structure and kinship are incorporated in a fixed and random effect Mixed Linear Model (MLM). However, because of the confounding between population structure, kinship, and qu...
PLOS146	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The molecular mechanisms that underpin the link between scabies and bacterial pathogens were unknown. We proposed that scabies mites play a role in the establishment, proliferation and transmission of opportunistic pathogens. We investigated here the synergy between mites and one of the most recognised mite associated ...
PLOS147	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Most bacteria live in biofilms, microbial communities that cause more than 80% of human infections. Biofilms have a genetically identical sub-population of dormant cells, named persister cells, which are the well-recognized source of antibiotic resistance. Recently, it was demonstrated that toxins are highly upregulate...
PLOS148	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Visceral leishmaniasis (VL), a vector-transmitted disease caused by Leishmania donovani, is potentially fatal if left untreated. Vaccination against VL has received limited attention compared with cutaneous leishmaniasis, although the need for an effective vaccine is pressing for the control of the disease. Earlier, we...
PLOS149	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Chromosomes are replicated during the cell cycle and distributed to two progeny cells on a machine called the spindle, such that each cell has one complete copy of the genome. The chromosomes are moved by attachment to the long microtubule polymers of the mitotic spindle, formed from a centrosome at each end of the spi...
PLOS150	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Organ size is coordinately regulated by cell proliferation and cell expansion; however, the mechanisms of organ size control are still poorly understood. We have previously demonstrated that the Arabidopsis F-box protein STERILE APETALA (SAP)/SUPPRESSOR OF DA1 (SOD3) controls organ size by promoting meristemoid prolife...
PLOS151	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Leptospirosis disease is widespread in humans and broad range of animal species in Africa. However, leptospirosis is highly neglected and not extensively taught in both medical and veterinary schools almost across Africa. Availability of live leptospires isolated from Africa for use in its diagnosis by the gold standar...
PLOS152	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Epidemiological and biological lines of evidence support a possible involvement of a sub-group of human papillomaviruses (HPV), referred to as cutaneous beta HPV types, in the development of non-melanoma skin cancer (NMSC). However, their role in carcinogenesis, in particular whether they synergize with other NMSC risk...
PLOS153	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Evolutionary dynamic models have been intensively studied to elucidate the process of tumorigenesis. One key aspect of studying tumorigenesis is to distinguish the “driver” mutations providing a fitness advantage to cancer cells against neutral “passenger” or “hitchhiking” mutations. Many statistical models to address ...
PLOS154	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Sperm and oocytes are essential for the faithful transmission of genetic information during sexual reproduction. As germ cells mature into sperm and oocytes, DNA double-strand breaks (DSBs) are deliberately created on each chromosome and a subset of DSBs is repaired to form meiotic crossovers between homologous chromos...
PLOS155	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Type 1 diabetes (T1D) rates have been increasing globally in recent decades; however, the contributing factors to this increase have not been established. Childhood obesity has been suggested to contribute to T1D risk. Since obesity rates in children have been increasing in recent years, they may explain part of the ri...
PLOS156	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Previous studies revealed spatially coherent and biological-meaningful chromatin mark combinations in human cells. Here, we analyze thirteen epigenetic mark maps in the human cell line K562 at 100 kb resolution of MRT data. The complexity of epigenetic data is reduced to four chromatin states that display remarkable si...
PLOS157	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Spatial patterning is a common feature of biological systems at all length scales, from molecular to multi-organismic. Meiosis is the specialized cellular program in which a diploid cell gives rise to haploid gametes for sexual reproduction. Crossing-over between homologous maternal and paternal chromosomes (homologs) ...
PLOS158	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	5–8 million people in Latin America are infected with the single-cell parasite Trypanosoma cruzi, the causative agent of Chagas disease. Of these, approximately one-third will develop chronic disease pathology, leading to disability and premature death. Only two drugs are available, both of which can have severe side e...
PLOS159	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Herpesviral capsid assembly is initiated in the host nucleus. Due to size constraints, newly formed nucleocapsids are unable to leave the nucleus through the nuclear pore complex. Instead herpesviruses apply an evolutionarily conserved mechanism for nuclear export of capsids called nuclear egress. This process is initi...
PLOS160	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Most herbivorous insects specialize on one or a few host plants; understanding the processes and genetics underlying this specialization has broad implications across biology. Drosophila sechellia, a fruit fly endemic to the Seychelles, feeds exclusively on the ripe fruit of Morinda citrifolia, a tropical plant commonl...
PLOS161	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Chlamydia trachomatis remains the leading bacterial agent of sexually transmitted disease worldwide and causes a form of blindness called trachoma in Developing nations, which is recognised by the World Health Organisation as a neglected tropical disease. Despite this burden, we know comparatively little about how it c...
PLOS162	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Metastasis is the spread of malignant tumor cells from their original site to other parts of the body and is responsible for the vast majority of solid cancer-related mortality. PARP inhibitors are emerging as promising anticancer therapeutics and are currently undergoing clinical trials. It is therefore important to e...
PLOS163	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	A third of stillborn babies in the UK are born at term (>37 weeks) and were previously considered to be healthy. Prolongation of pregnancy at term is a known risk factor for stillbirth. Currently women are routinely offered induction of labour after 41 weeks gestation to avoid stillbirth. But 1 in 3 women have a stillb...
PLOS164	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The actomyosin cytoskeleton is the primary force that drives cell shape changes. These fibers are organized in elaborate structures that form sarcomeres in the muscle and the contractile ring during cytokinesis. In cytokinesis, the establishment of an equatorial actomyosin ring is preceded and regulated by many cell cy...
PLOS165	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The sequencing of full genomes and the development of high-throughput analysis technologies have made available both genome-scale metabolic networks and simultaneous transcription data for all the genes of an organism. Genome-scale metabolic models, with the assumption of steady state for the internal metabolites, allo...
PLOS166	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The incidence of complex diseases such as diabetes, asthma, and depression is almost epidemic in many countries and coincides with transition in lifestyles. Clearly this is a result of interaction between modern cultural and environmental factors with the genetic legacy of human history. To estimate the extent of the e...
PLOS167	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The evolution of multicellular animals (metazoans) from their single-celled ancestor required new molecular tools to create and coordinate the various biological functions involved in a communal, or multicellular, lifestyle. This would eventually include the unique cellular and physiological demands of specialized tiss...
PLOS168	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Understanding the role of genetic variants within a viral population is a necessary step toward predicting and treating emerging infectious diseases. The high mutation rate of RNA viruses increases the ability of these viruses to adapt to diverse hosts and cause new human and zoonotic diseases. The genetic diversity of...
PLOS169	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The photoperiodic flowering in Arabidopsis requires the key regulator CO and its target gene FT. However, how CO regulates FT expression in the context of chromatin remains largely obscure. In this work, we present Arabidopsis MRG1/2 as novel chromatin effectors directly involved in the CO-FT photoperiodic flowering. F...
PLOS170	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	A fundamental goal of population genetics is to understand why levels of genetic diversity vary among species and populations. Under the assumptions of the neutral model of molecular evolution, the amount of variation present in a population should be directly proportional to the size of the population. However, this p...
PLOS171	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	NPC1 and NPC2 proteins are involved in cholesterol trafficking in mammals. Using different approaches, we have detected the orthologues EhNPC1 and EhNPC2 proteins in Entamoeba histolytica. Trophozoites are particularly rich in membranes and vacuoles, but they do not possess the machinery to synthetize cholesterol. Thus...
PLOS172	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Spinal muscular atrophy is a debilitating disease that affects the motor nervous system. The disease is caused by the reduction of the protein survival motor neuron (SMN), which is involved in the assembly of ubiquitous small nuclear ribonucleoproteins. As SMN is required in every cell, it is important to understand th...
PLOS173	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Chagas disease is a major health problem in Latin America. Its infectious agent, Trypanosoma cruzi, is transmitted mainly by the feces of insects called triatomines. Although great progress has been made in reducing transmission in the countries in the southern cone of South America, limited progress has been made in t...
PLOS174	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Chikungunya virus (CHIKV), the etiologic agent of chikungunya fever (CHIK), is a positive sense, single-stranded RNA virus in the genus Alphavirus. Chikungunya fever begins as a flu-like illness, which progresses to severe arthralgia and debilitating arthritis. This syndrome is often self-limited and rarely fatal; howe...
PLOS175	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The contribution of genetic variation to phenotypic variation is well-established. By contrast, it is unknown how frequently epigenetic variation causes differences in organismal phenotypes. Epigenetic information is closely associated with but not encoded in the DNA sequence. In practice, it is challenging to disentan...
PLOS176	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Normal cells have robust mechanisms to maintain the proper sequence of their DNA; in cancer cells these mechanisms are compromised, resulting in complex changes in the DNA of tumors. How this genome instability begins has not been defined, except in cases of familial cancers, which often have mutations in genes called ...
PLOS177	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	All multicellular organisms have developed mechanisms to defend themselves against predators, parasites and pathogens. As a common mechanism, animals, plants and fungi use a large arsenal of carbohydrate-binding proteins (lectins) to protect themselves from predation and parasitism. The success of this type of innate d...
PLOS178	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Using a dataset of more than 130,000 de novo mutations we show that there is large-scale variation in the mutation rate at the 100KB and 1MB scales. We show that different types of mutation vary in concert and in a manner that is not expected to generate variation in base composition; hence mutation bias is not respons...
PLOS179	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Is neural activity more than the sum of its individual parts? What is the impact of cooperative, or correlated, spiking among multiple cells? We can start addressing these questions, as rapid advances in experimental techniques allow simultaneous recordings from ever-increasing populations. However, we still lack a gen...
PLOS180	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Hepatitis C virus (HCV) chronically infects 130 million people and is a major cause of cirrhosis and liver cancer. The current antiviral therapy of pegylated interferon-2 alfa + ribavirin is successful in only half of treated patients. This has led to an intensive effort to design improved therapeutic strategies. The i...
PLOS181	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Lymphatic filariasis (LF) is a neglected tropical disease (NTD) that is targeted for elimination and is thought to be potentially eradicable through once yearly mass drug administration (MDA) using drugs that are currently donated to LF endemic countries by the pharmaceutical companies that manufacture them. MDA has pr...
PLOS182	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The strength of ecological interactions, measured as the costs or benefits sustained by each species, depends on the environmental context in which the interaction occurs. Stressful environmental conditions should favor trading between species that can produce a given resource or service at the lowest cost. Mutualisms,...
PLOS183	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	One role for silent heterochromatin is to preserve the integrity of the genome by stabilizing regions rich in repetitive sequence and mobile elements. Compaction of repetitive sequences by heterochromatin is needed to prevent genome rearrangement and loss of genetic material. Furthermore, uncontrolled movement of mobil...
PLOS184	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Opisthorchiasis, caused by the food-borne trematode Opisthorchis viverrini, affects more than 8 million people in Southeast Asia, and in its chronic phase it might lead to cholangiocarcinoma. Praziquantel (PZQ) is the sole drug available to treat the disease and is administered as a racemic mixture of R and S enantiome...
PLOS185	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Leishmaniases are a set of tropical and sub-tropical diseases caused by protozoan parasites of the genus Leishmania. They affect about 12 million people and cause a high morbidity. Since treatments against all forms of leishmaniasis are limited in number and efficacy, many efforts are made to identify potential drug ta...
PLOS186	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Prions are infectious agents causing irremediably fatal neurodegenerative diseases in human and in farmed or wild animals. They are thought to be formed from abnormally folded assemblies (PrPSc) of the host-encoded prion protein (PrPC). Different PrPSc conformational variants associated with distinct biological phenoty...
PLOS187	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Human hepatocellular carcinoma (HCC) is one of the most common malignancy worldwide and among the leading causes of cancer-related death. HCC is often diagnosed at an advanced stage and there is still no effective therapeutic strategy for non-resectable HCCs. It has been suggested that the therapeutic delivery of certa...
PLOS188	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The production of red blood cells, platelet-producing megakaryocytes, and immune response-directing granulocytes and monocytes is initiated at an early stage in the developing embryo and continues throughout life. The proportion of each cell type varies depending on the specific needs of the organism. We know that in t...
PLOS189	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Cholera is a potentially deadly diarrheal disease caused by toxin-secreting strains of Vibrio cholerae. The bacterium can trigger severe epidemics in countries with limited access to potable water and sanitation. Hygiene promotion, proper sanitation and improved access to safe drinking water are essential to control ch...
PLOS190	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Antiretroviral therapy (ART) does not eradicate HIV-1 in infected individuals due to virus persistence in latently infected reservoir cells, despite apparently effective ART. The persistent virus and can rekindle infection when ART is interrupted. The goal of the “shock and kill” viral clearance strategy is to induce e...
PLOS191	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The differentiation process has classically been seen as a stereotyped program leading from one progenitor toward a functional cell. This vision was based upon cell population-based analyses averaged over millions of cells. However, new methods have recently emerged that allow interrogation of the molecular content at ...
PLOS192	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Salmonella enterica serovar Typhimurium is a foodborne pathogen that causes gastroenteritis in humans. To successfully trigger infection, S. Typhimurium invades epithelial cells, a process that requires the coordinated expression of a set of genes. HilD is a pivotal regulator of S. Typhimurium pathogenicity, as it acti...
PLOS193	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Microorganisms play a crucial role in nutrient biogeochemical cycles. Arsenic is found throughout the environment from both natural and anthropogenic sources. Its inorganic forms are highly toxic and impair the physiology of most higher organisms. Arsenic contamination of groundwater supplies is giving rise to increasi...
PLOS194	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Dietary guidelines promote intakes of polyunsaturated fatty acids (PUFAs) for cardiometabolic health, whereas evidence on PUFAs for pregnant women is scarce. Experimental and observational studies have linked both dietary and circulating fatty acids to the risk of developing type 2 diabetes, insulin resistance, and β-c...
PLOS195	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	During HIV infection, a small proportion of infected cells containing integrated proviral DNA enter a long-lived resting phase, thus creating latent reservoirs of virus. These reservoirs are a major barrier to curing HIV and have been studied intensively in this light. Latent reservoirs might also affect viral dynamics...
PLOS196	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Schistosomes are parasitic worms that infect hundreds of millions of people in developing countries. They cause disease by virtue of the fact that the eggs that they produce, which are intended for release from the host in order to allow transmission of infection, can become trapped in target organs such as the liver, ...
PLOS197	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Apicomplexan parasites infect many different hosts and tissues, causing numerous human diseases, including malaria. These important pathogens have a peculiar cell cycle in which chromosomes sometimes amplify to remarkable levels, followed by concerted cell division—providing an unusual proliferative capacity. This capa...
PLOS198	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Two-component signal transduction systems are a primary means of regulating gene expression in bacteria. Recognizing the diversity of mechanisms associated with these systems is therefore critical to understanding the full signaling potential of bacterial cells. We have analyzed the behavior of two orphan, atypical res...
PLOS199	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Yellow fever is becoming one of the most important re-emerging mosquito-borne viral diseases in many African countries despite the availability of an effective vaccine. Hence, assessing information on what a community knows about Yellow fever would contribute to the design of appropriate control strategies in addition ...

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