Split (3)

train · 1k rows

id stringlengths 5 7	query stringlengths 4.64k 8.32k	answer stringlengths 392 2.53k
PLOS400	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Salmonella are a group of bacteria that cause illnesses and death worldwide. There are two types of Salmonella–Typhi and non-typhoidal (NTS). In humans, the majority of illnesses caused by NTS are related to gastro-intestinal problems, though uncommonly, it also invades the bloodstream. On the other hand, typhoid fever...
PLOS401	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Almost all cellular mRNAs terminate in a 3′ poly(A) tail, the removal of which can induce both translational silencing and mRNA decay. Mammalian cells encode many poly(A)-specific exoribonucleases, but their individual roles are poorly understood. Here, we undertook an analysis of the role of PARN deadenylase in mouse ...
PLOS402	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Macrophages are one of the major target cells for HIV-1 infection and play an important role in viral pathogenesis. Previous studies indicated that the pathway of HIV-1 particle morphogenesis is distinct in primary human macrophages, and this has been suggested to play a role in viral persistence. Early reports indicat...
PLOS403	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Mitochondrial pathologies which result from mutations in the nuclear DNA remain incurable and often lead to death. As mitochondria play various roles in cellular and tissue-specific contexts, the symptoms of mitochondrial pathologies can differ between patients. Thus, diagnosis and treatment of mitochondrial disorders ...
PLOS404	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In this study, we compared measures of entomological risk collected through routine household entomological monitoring by estimating an association with human DENV infection. Longitudinal entomological and human serology data from Iquitos, Peru, were used to test associations between Ae. aegypti indices and the 6-month...
PLOS405	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Infectious diseases cause important health problems worldwide and create difficult challenges for public health policy makers. That is why they need reliable computational tools to better understand disease and to predict case counts. They will benefit from such computational tools to make more informed decisions in de...
PLOS406	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	There are many examples of recent emergence of mosquito-borne viruses, such as chikungunya virus outbreaks throughout the Caribbean in 2013, Zika virus outbreaks throughout Southern and Central America in 2015, and yellow fever virus in Brazil in 2017. Each outbreak draws attention to the limits associated with predict...
PLOS407	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Gene signatures are a powerful tool to investigate biological processes in human cancer. However, it is clear that these gene signatures do not fully reflect the complexity of human cancer. Here we demonstrate how a latent factor model can improve the in vivo relevance of these pathway-associated gene signatures by dis...
PLOS408	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Understanding how proteins recognize each other is central to deciphering the inner workings of living things and for biomedical research. It has long been known that the sequence of a protein, which is a string of different amino acids, can dictate how a protein molecule folds into a well-defined shape required for bi...
PLOS409	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Economic theory assumes that we assign some sort of value to options that are presented to us in order to choose between them. In neuroscience, evidence suggests that memory brain regions, such as the hippocampus, are involved in imagining novel situations. We therefore hypothesized that the hippocampus might be critic...
PLOS410	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Dystrophin is a long rod-shaped protein that forms a complex with several membrane and cytoplasmic proteins in muscle. Genetic defects in components of this dystrophin complex are responsible for many forms of muscular dystrophy, including Duchenne muscular dystrophy. C. elegans possesses the dystrophin complex and mut...
PLOS411	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Ethylene is one of the most essential hormones for plant developmental processes and stress responses. However, the phosphorylation regulation in the ethylene signaling pathway is largely unknown. Here we found that ethylene induces the phosphorylation of CBP20 at S245, and the phosphorylation is involved in root growt...
PLOS412	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	One of the challenging tasks in systems biology is to quantitatively predict the metabolic behavior of the cell under given genetic and environmental constraints. To this end, genome-scale metabolic reconstructions and simulation tools are indispensable. The choice of the objective function to be used for simulating ge...
PLOS413	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In response to DNA damage all eukaryotic cells activate a surveillance mechanism, known as the DNA damage checkpoint, which delays cell cycle progression and modulates DNA repair. Yeast RAD9 was the first DNA damage checkpoint gene identified. The genetic tools available in this model system allow to address relevant q...
PLOS414	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The functional expression of DNA sequence depends on the chromatin status. Epigenetic marks at specific loci could affect local chromatin accessibility, thus affect the gene activity of that loci. We applied an enzyme methylome approach to globally detect one type of epigenetic mark, cytosine methylation at CCGG restri...
PLOS415	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Chagas disease is caused by the parasite Trypanosoma cruzi, which is transmitted by kissing bugs in endemic areas located in Central and South America. In its acute phase, the disease has unspecific and mild symptoms, whereas in the chronic phase infected individuals might develop severe cardiomyopathy. For many years,...
PLOS416	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Although relatively mild, the 2009 H1N1 pandemic reminded us once again of the on-going threat posed by novel respiratory viruses and the need for understanding better how such pathogens emerge and spread. From April to September 2009, countries in temperate regions of the Southern hemisphere experienced large epidemic...
PLOS417	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In spite of the rapid development of antiviral agents, antiviral resistance remains a challenge for the treatment of viral infections including hepatitis B and C virus (HBV, HCV), human immunodeficiency virus (HIV) and influenza. Virus spreads from infected cells to surrounding uninfected host cells to develop infectio...
PLOS418	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Human leukocyte antigen (HLA) class I molecules present pathogen-derived components (peptides) to cytotoxic T cells, thereby inducing the T cells to kill virus-infected cells. A complex cellular pathway involving the transporter associated with antigen processing (TAP) is typically required for the loading of peptides ...
PLOS419	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	AID (Activation Induced Deaminase) deaminates cytosines in DNA to initiate immunoglobulin gene diversification and to reprogram the genome in early development. AID is potentially highly mutagenic, as it deaminates C to U within single-stranded regions. Here we show that AID abundance is regulated by cell cycle, and th...
PLOS420	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The establishment of single-celled leaf hairs (trichomes) from pluripotent epidermal (protodermal) cells provides a powerful system to determine the gene regulatory networks involved in plant cell fate determination. Two transcription factors—GL1 and GL3—have been associated with the initiation of trichome formation; y...
PLOS421	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Scrub typhus is an infectious disease common in Southeast Asia, caused by the intracellular bacteria Orientia tsutsugamushi. These microorgansims infect humans through chigger mite bites, after which O. tsutsugamushi invades cells in the dermis, causing an inflammatory lesion called an eschar. Other rickettsia causing ...
PLOS422	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Neurodegenerative diseases encompass a wide range of clinical conditions remaining incurable while the genetic and molecular basis of most of these conditions remains unknown due to their heterogeneity and the lack of animal models. Mutations in nuclear genes encoding mitochondrial proteins have recently emerged as nov...
PLOS423	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Rabies virus continues to cross carnivorous species and to infect humans and livestock in China. Rabies vaccination of the principal reservoir animals is even now being neglected in most regions of China, resulting in continuous expansion of rabies epidemics. Since there is no oral vaccine for stray dogs and wild anima...
PLOS424	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	It is still unknown to what extent ecological associations between microbes, as measured by co-occurrence of different taxa in 16S rRNA surveys, can be explained, or predicted, using composition and structure of microbial genomes alone. Here I introduce two new genome-wide, pairwise indices for quantifying the propensi...
PLOS425	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Cytokinesis is the finalizing step of the complex scenario of mitosis, leading to separation of two sister cells. The cellular mechanism of cytokinesis in eukaryotes differs at least between yeasts, plants and animals. So far, it is also not clear whether all mammalian cells follow the same mechanistic rules of cytokin...
PLOS426	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Bacterial pathogens frequently evolve mechanisms to vary the composition of their surface structures. The consequence is enhanced long-term survival by facilitating persistence and evasion of the host immune system. Salmonella sp., cause severe infections in a range of mammalian hosts and guard themselves with a protec...
PLOS427	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Schistosomiasis, a disease caused by worms from the genus Schistosoma, is one of the most widespread neglected tropical diseases in the world. Due to the intensive use of praziquantel, some reports of drug resistance have emerged. Thus it is important to search for new chemotherapeutic agents for the treatment disease....
PLOS428	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Enteroviruses contain a large number of closely related human pathogens, including poliovirus, EV71, and coxsackie viruses, and cause ~3 billion infections annually. Among the nonstructural proteins of enteroviruses or picornaviruses, protein 2CATPase is the most conserved and complex but the least understood. On the b...
PLOS429	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Auxin is an important plant hormone which regulates many aspects of plant growth and development, such as embryogenesis and directional growth in response to light or gravity. Recent molecular genetics advances in angiosperms revealed that transcriptional regulation is critical for auxin response. Although auxin respon...
PLOS430	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Calcium is vital to all living organisms. It is used within cells to regulate many essential processes and, because of this, its cellular concentration is tightly controlled. To change cellular calcium levels, cells use calcium transport proteins. These proteins can alter calcium concentration by moving calcium into or...
PLOS431	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	We studied intestinal helminth infection status in primary-school children and the hygiene conditions of primary schools in Ikenne Local Government Area of Ogun State, Nigeria in order to help guide the development of school-based health programmes. Two government-owned schools (one urban and the other rural) plus one ...
PLOS432	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Humans and animals are able to learn complex behaviors based on a massive stream of sensory information from different modalities. Early animal studies have identified learning mechanisms that are based on reward and punishment such that animals tend to avoid actions that lead to punishment whereas rewarded actions are...
PLOS433	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	An RNA molecule is made up of a linear sequence of nucleotides, which form pairwise interactions that define its folded three-dimensional structure; the particular structure largely depends on the specific sequence. These base-pairing interactions are stabilizing, and the RNA will tend to fold in a particular way to ma...
PLOS434	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Describing the multiple conformations of proteins is important for understanding the relationship between molecular flexibility and function. However, most methods for interpreting data from X-ray crystallography focus on building a single structure of the protein, which limits the potential for biological insights. He...
PLOS435	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Human African Trypanomiasis (HAT) is among a list of Neglected Tropical Diseases (NTDs) that impose devastating burdens on both public health and economy of some of the most unprivileged societies across the world. To secure the long-term global control of the disease, it is critical to understand the mechanisms underl...
PLOS436	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The biological interpretation of most disease-associated variants has become a real challenge, especially with the implementation of next-generation sequencing. Particular attention is typically given to protein-coding changes often neglecting the potential impact of exonic variants on RNA splicing. Here, we used the e...
PLOS437	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The standard approach in genome-wide association studies is to analyse the relationship between genetic variants and disease one marker at a time. Significant associations between markers and disease are then used as evidence to implicate biological intermediates and pathways likely to be involved in disease aetiology....
PLOS438	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In mammals, secreted host defence peptides (HDPs) protect against a wide range of infectious pathogens. They also perform a range of immune modulatory functions which regulate the immune response to pathogens, ensuring that the protective inflammatory response is not exacerbated and that post-infection repair mechanism...
PLOS439	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Adherence clubs are an intervention to retain people living with HIV on antiretroviral therapy (ART) and decongest busy clinics in high-burden settings. In adherence clubs, groups of 20–30 patients meet every other month for a 1-hour counseling and medication pickup session in a clinic or community setting. There is cu...
PLOS440	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Chagas disease is caused by the protozoan parasite Trypanosoma cruzi, constituting an important health problem in the American Continent. In the Brazilian Amazon, Chagas disease has been recognized as an emerging problem. There are few studies exploring the genetic and biological framework of stocks of T. cruzi from th...
PLOS441	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	There is a growing body of evidence indicating that mitochondrial dysfunction, a result of genetic variation in the mitochondrial genome, is a critical component in the aetiology of a number of complex traits. Here, we take advantage of recent technical and methodological advances to examine the role of common mitochon...
PLOS442	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Being endemic in several countries in Asia, Africa, the Middle East and Southeastern Europe, the Crimean-Congo Hemorrhagic Fever Virus (CCHFV) is the geographically most widespread tick-borne arbovirus. As evidenced by the recent occurrence of an autochthonous CCHFV infection in Spain, it possesses also a significant p...
PLOS443	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In the late 1960s, Mark Kac asked, "Can one hear the shape of a drum?" challenging readers to reconstruct the geometry of the drum from a provided list of overtones. Physicists and mathematicians found that, although in general, one cannot hear the shape of a drum, many of its properties, such as its area and perimeter...
PLOS444	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Much of our current understanding of how proteins mediate membrane fusion derives from the study of enveloped virus fusion proteins. These fusion protein complexes function autonomously to co-ordinately regulate virus–cell attachment and subsequent membrane merger. In contrast, the reovirus Fusion-Associated Small Tran...
PLOS445	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Transposable elements comprise major portions of most animal genomes and are selfish genetic elements that may encode proteins needed for their own spread to new genomic locations. Though often considered genomic parasites, these elements also occasionally create novel genes that prove beneficial to the host, a process...
PLOS446	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	In soybean plants, low-phosphorus (P) stress is more detrimental than other nutrient deficiencies, toxicities or diseases; however, it is difficult to select soybean varieties with high P efficiencies based on phenotypes. Although QTL map-based cloning is a powerful method, it is time-consuming, and the QTLs underlying...
PLOS447	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Mutations in the amyloid protein precursor (APP), presenilin-1 (PSEN1), and presenilin-2 (PSEN2) genes are a known cause of familial, early-onset Alzheimer disease (EOAD) (onset below age 65). However, in order to improve genetic counseling, it is necessary to report mutational screening from large cohorts of patients....
PLOS448	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Animals use behavior as one of the principal means of meeting their basic needs and responding flexibly to changes in their environment. An emerging insight is that changes in behavior are associated with massive changes in gene expression in the brain, but we know relatively little about how these changes are regulate...
PLOS449	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	As one of the most prevalent parasitic infections worldwide, schistosomiasis is caused by blood-flukes of the genus Schistosoma. Pathology coincides with egg production, which is started upon pairing of the dioeciously living adults. A constant pairing contact is required to induce mitoses and differentiation processes...
PLOS450	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	There are more than 2 million people receiving hemodialysis (HD) treatment worldwide. Cardiovascular disease is the most common cause of death in those patients. There are several non-invasive methods to assess if a person from general population has a high risk for developing cardiovascular disease, but it is unclear ...
PLOS451	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Pseudomonas aeruginosa causes serious infections in people with compromised immune systems. Individuals with Cystic Fibrosis and hospital patients are particularly vulnerable to P. aeruginosa infections. This bacterium does not respond to many antibiotics, making these infections difficult to treat. P. aeruginosa can g...
PLOS452	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The free-living amoeba, Naegleria fowleri, is commonly found in water sources including swimming pools having inadequate levels of chlorine, lakes, and rivers. N. fowleri can act as an opportunistic pathogen causing severe brain injury called Primary Amebic Meningoencephalitis (PAM), often in healthy children and young...
PLOS453	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Cystic hydatid disease (CHD), caused by the dog tapeworm, Echinococcus granulosus, is hyperendemic in western China. However, until recently the disease had been grossly neglected there due primarily to a weak economy and the primitive control measures used. The situation is now changing because of China's growing econ...
PLOS454	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Small for gestational age (SGA) occurs in more than 30 million infants every year. SGA has been associated with increased risks of stillbirth and neonatal mortality, but data on long-term childhood mortality are scarce. We evaluated the association between SGA and mortality from 28 days after birth to 18 years of age, ...
PLOS455	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The interactions between proteins play a crucial role for almost every undertaking of a cell. Many of these interactions are mediated by the binding of relatively short unstructured polypeptide segments, or peptides, in one protein to well-folded domains in other proteins. Such protein-peptide interactions have some in...
PLOS456	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Chagas disease is among the most serious public health problems in Latin America; the highest prevalence of infection by its causative agent, the parasite Trypanosoma cruzi, has historically been recorded in some parts of Bolivia. In the early 2000s, a massive insecticide-spraying program was set up to control dwelling...
PLOS457	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	A quantitative description of transcription factor (TF) binding in vivo is critical for our understanding of gene regulation. Chromatin Immunoprecipitation followed by sequencing (ChIP-seq) provides a genome-scale map of TF-binding. However, a quantitative characterization of the impact of genome accessibility on TF-bi...
PLOS458	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The transition of vertebrates from water to land is a fundamental step in the evolution of terrestrial life. Innovations that were critical to this transition were the evolution of a weight bearing pelvis, hindlimbs and their associated musculature, and the development of the “rear wheel drive” strategy that predominat...
PLOS459	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The Ca2+-independent phospholipase A2 (iPLA2) enzyme is a potential target for the development of medicinal agents against heart and neurological diseases, multiple sclerosis, arthritis, and cancer. However, no structural information is currently available for the iPLA2. The binding of the enzyme to human membranes is ...
PLOS460	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Arthropod-borne pathogens account for millions of deaths each year. Understanding the genetic mechanisms controlling arthropod susceptibility to pathogens has profound implications for developing novel strategies for controlling insect-transmitted infectious diseases. Although it was postulated that apoptosis (a geneti...
PLOS461	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	We have examined the role of two factors, RAD52 and POLQ, in genome maintenance pathways. While these factors are biochemically distinct, they are both synthetic lethal with loss of the BRCA1 and BRCA2 tumor suppressor genes, and hence are emerging therapeutic targets. Furthermore, RAD52 and POLQ have been implicated i...
PLOS462	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Dengue infection along with its related disease conditions poses a significant threat to human populations. The pathogen responsible for this infection is dengue virus (DENV), which is primarily transmitted to humans through the bites of Ae. aegypti mosquitoes. Unavailability of vaccines has recently sparked research e...
PLOS463	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Despite being a part of the normal flora of healthy individuals, Candida albicans is the most common fungal pathogen of humans and can cause infections that are associated with staggeringly high mortality rates. Here we devise a model for the study of the host immune response to C. albicans infection using the nematode...
PLOS464	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Zika virus (ZIKV) infection has become a major concern due to its association with congenital birth defects and Guillain-Barré Syndrome. We enrolled 33 laboratory-confirmed Zika cases (index cases) and their household members (109 contacts) in Managua, Nicaragua, and followed them for three weeks, collecting serum/plas...
PLOS465	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	FoxA transcriptional regulatory proteins are “pioneer factors” that engage silent genes, helping to endow the competence for activation. About a third of the DNA sites we found to be occupied by FoxA in the adult liver are at genes that are silent. Analysis of transcription factor binding motifs near the FoxA sites at ...
PLOS466	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	EBV is an oncogenic virus involved in the development of about 1.5% of human cancers worldwide. EBV infection has latent and lytic forms. Both forms of infection contribute to the oncogenic capacity of the virus. During the lytic cycle, a cascade of temporally regulated events takes place leading to release of new viru...
PLOS467	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Suboptimal diet is a leading cause of cardiovascular disease, death, and health disparities. Dietary policies have the potential to reduce this burden. However, the potential benefits of policies targeting fruit, vegetable, and sugar-sweetened beverage consumption in the whole US population and among those participatin...
PLOS468	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Consistently wearing shoes may help in preventing onset or progression of a wide range of Neglected Tropical Diseases (NTDs). This study assessed the factors that influenced shoe wearing behaviors among people living in a rural community in highland Ethiopia. In this community, a substantial proportion of people are at...
PLOS469	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Despite the long recognition that skunks are an important reservoir host for rabies, the control of this disease among this host has not been achieved, and the disease is currently only passively monitored in North America. The need for rabies control among striped skunks is, however, well acknowledged, and reports of ...
PLOS470	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Even with recent progress in determining the genetic basis of complex diseases, the issue of ‘missing heritability’ remains and its potential sources are frequently speculated about but rarely explained. Parent-of-origin effects might contribute to the ‘missing heritability’ and involve genetic and epigenetic mechanism...
PLOS471	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Pathogenic bacteria use a weapon called the ‘Type VI secretion system’ (T6SS) to fire toxic proteins into other cells. These target cells are very often rival bacteria, allowing the T6SS-wielding bacteria to outcompete other pathogens or harmless bacteria. Some bacteria deploy this weapon defensively, only firing back ...
PLOS472	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The collective movement of animals in a group is an impressive phenomenon whereby large scale spatio-temporal patterns emerge from simple interactions between individuals. Theoretically, much of our understanding of animal group motion comes from models inspired by statistical physics. In these models, animals are trea...
PLOS473	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Episodic memories relate positive or negative experiences to environmental context. The neurophysiological mechanisms of this connection, however, remain unknown. Hippocampal place cells represent location, but it is unclear if they encode only the spatial representation of the environment or if they are also processin...
PLOS474	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Innate immunity represents the first line of defense against invading pathogens chiefly through anti-viral cytokines. The mitochondrial antiviral signaling (MAVS)-dependent innate immune pathways are critical for inflammatory cytokine production. Deficiency in essential innate immune components, such as MAVS, severely ...
PLOS475	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The biology of germ cells is intimately intertwined with meiosis. Meiosis I is a unique biological event, when chromosomes pair, recombine, and segregate. The synaptonemal complex is a protein lattice that enables chromosome pairing and recombination and is unique to meiosis I. Meiosis I requires a subset of factors th...
PLOS476	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	As public health agencies strive to harness big data to improve outbreak surveillance, they face the challenge of extracting meaningful information that can be directly used to improve public health, without incurring additional costs. In this article, we address the question: Which nodes in a social network should be ...
PLOS477	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	As modern experimental techniques uncover new components in biological systems and describe their mutual interactions, the problem of determining the contribution of each component becomes critical. The many feedback loops created by these interactions can lead to oscillatory behavior. Examples of oscillations in biolo...
PLOS478	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Native DNA usually folds to form the canonical double helix, however, under certain conditions, it can also fold into other secondary structures. Some of the most interesting ones are G-quadruplexes (G4)—compact DNA structures in which guanines assemble into multilayered tetrads, and whose formation has been reported a...
PLOS479	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Understanding how the brain makes sense of our acoustic environment remains a major challenge. One way to describe the complexity of our acoustic environment is in terms of information entropy: acoustic signals with high entropy convey large amounts of information, whereas low entropy signifies redundancy. To investiga...
PLOS480	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Genome-wide association studies (GWAS) have identified hundreds of regions of the human genome that are associated with susceptibility to common diseases. Yet many lines of evidence indicate that many susceptibility loci, which cannot be detected by standard statistical methods, remain to be discovered. We have develop...
PLOS481	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Mosquitoes are vectors of numerous human diseases including malaria. Disease transmission requires that microbes overcome the robust mosquito immune system. In the African malaria mosquito, the TEP1 protein that is homologous to mammalian complement factor C3 is shown to play a central role in mosquito immunity to mala...
PLOS482	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	When analyzing metabolic networks, one often searches for metabolic pathways with certain (desired) properties, for example, conversion routes that maximize the yield of a product from a given substrate. While those problems can be solved with established methods of constraint-based modeling, no algorithm is currently ...
PLOS483	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Bacterial infection begins with microbial adhesion to host cells. For gram-negative bacteria, adhesion is often mediated by pili, proteinaceous polymers that protrude from the bacterial surface and recognize host receptors. During assembly, each pilus protein subunit is assisted in folding by a chaperone that shuttles ...
PLOS484	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Polarity allows the specialization of cell function and is required to coordinate cell movements, differentiation, proliferation and apoptosis to build and maintain complex tissues such as the mammary gland. Disruption of polarity is a diagnostic criterion of cancer, but exactly how deregulation of core polarity genes ...
PLOS485	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Chagas disease is caused by the Trypanosoma cruzi protozoan, which is transmitted to vertebrates through the feces of infected triatomines during blood sucking. The vascular injury caused by the bite triggers mechanisms capable of preventing the association with hosts, such as immune response, inflammation and haemosta...
PLOS486	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Young macaques kept in captivity at Primate Research Centers often develop chronic diarrhea, which is difficult to treat because it is poorly understood. This disease shares many features with ulcerative colitis, which is an autoimmune disease affecting the intestinal tract of humans. Recently, parasitic worms have bee...
PLOS487	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Data on the prevalence and distribution of Strongyloides stercoralis (threadworm) is scarce in many resource-poor countries. We carried out a cross-sectional study during the dry season among 2,396 rural Cambodians of all ages. We used a rigorous diagnostic approach, involving two stool samples per person and two exami...
PLOS488	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Amyloid diseases are characterized by the presence of amyloid fibrils on organs and tissue in the body. Alzheimer's disease, Parkinson's diseases and Type II Diabetes are all examples of amyloid diseases. Determining the structure of amyloid fibrils is critical for understanding the mechanism of fibril formation as wel...
PLOS489	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Burkholderia pseudomallei is a bacterium that infect macrophages and other cell types and causes a diseases called melioidosis. Inflammasomes are multiprotein complexes that control activation of the proteases caspase-1 and caspase-11 resulting in production of the inflammatory mediators IL-1β and IL-18 and death of in...
PLOS490	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The number of individuals in sub-Saharan Africa needing antiretroviral therapy (ART) for HIV—and chronic disease care more broadly—is expected to increase over the coming decades, further straining already under-resourced health systems in the region. Community delivery of antiretroviral drugs (ARVs) has the potential ...
PLOS491	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Starvation is a common physiological condition encountered by most organisms in their natural environments. However, the molecular mechanisms that allow organisms to accurately sense nutrient availability and match their energetic demands accordingly are not well understood. To elucidate these mechanisms, we isolated m...
PLOS492	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	The TLR pathway mediated antiviral immune response is well identified in mammals, yet, Toll pathway governing this protection in invertebrates remains unknown. In the present study, we uncover that a shrimp Toll4 from a total of nine Tolls in L. vannamei confers resistance to WSSV thought inducing the NF-κB transcripti...
PLOS493	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	When cells duplicate their genome, the replication machinery is constantly at risk of encountering obstacles, including unusual DNA structures, bound proteins, or transcribing polymerases and transcripts. Cells possess DNA helicases that facilitate movement of the replication fork through such obstacles. Here, we repor...
PLOS494	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Our genome harbors epigenetic marks, such as DNA methylation (DNAm) at cytosine residues, which govern cellular differentiation. Some epigenetic modifications accumulate throughout life in a highly reproducible manner–they may contribute to the aging process and facilitate reliable age-predictions. So far, little is kn...
PLOS495	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Skin infection, oral and vaginal thrush, or bloodstream candidiasis are some of the diseases caused by the human pathogen Candida albicans. The high versatility of infection niches reflects the capacity of this yeast to respond to strong variations in its environment such as CO2 concentration. This molecule initiates t...
PLOS496	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Visceral leishmaniasis (VL) affects organs rich in lymphocytes, being characterized by intense Leishmania-induced T-cell depletion and reduction in other hematopoietic cells. In other infectious and non-infectious diseases in which the immune system is affected, such as HIV-AIDS and inflammatory bowel disease, damage t...
PLOS497	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	When organisms are exposed to different environments, the rates and types of mutations that spontaneously arise in each environment can vary due to differing mutagenic pressures imposed by each environment, and these can potentially influence the evolution of the organism. Little is known about the types of mutations t...
PLOS498	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Proteins interact with each other in a network manner to precisely regulate complicated physiological functions of life. Diseases such as cancer may occur if the network regulations go wrong. In cancer research, network mining has been utilized to identify biomarkers, predict therapeutic targets, and discover new mecha...
PLOS499	*TASK* the task is to simplify the input abstract of a biomedical literature *INPUT* the input is the abstract of a biomedical literature *OUTPUT* the output is the simplified abstract for the input abstract of a biomedical literature *DOCUMENTATION* *EXAMPLES* Input: Output: *EXAMPLES* Inp...	Protein interactions are important for all life processes, and an ability to rationally control or selectively inhibit protein complexes would impact studies of cellular structure, biological information processing, molecular regulatory processes and other phenomena. Rational protein design has applications in developi...

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