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"O",
"B-T038",
"I-T038",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
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"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
... | [
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"db_id": "C0854135",
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"db_id... | [
"DCTN4",
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95,... | DCTN4 as a modifier of chronic Pseudomonas aeruginosa infection in cystic fibrosis Pseudomonas aeruginosa (Pa) infection in cystic fibrosis (CF) patients is associated with worse long-term pulmonary disease and shorter survival, and chronic Pa infection (CPA) is associated with reduced lung function, faster rate of lung decline, increased rates of exacerbations and shorter survival. By using exome sequencing and extreme phenotype design, it was recently shown that isoforms of dynactin 4 (DCTN4) may influence Pa infection in CF, leading to worse respiratory disease. The purpose of this study was to investigate the role of DCTN4 missense variants on Pa infection incidence, age at first Pa infection and chronic Pa infection incidence in a cohort of adult CF patients from a single centre. Polymerase chain reaction and direct sequencing were used to screen DNA samples for DCTN4 variants. A total of 121 adult CF patients from the Cochin Hospital CF centre have been included, all of them carrying two CFTR defects: 103 developed at least 1 pulmonary infection with Pa, and 68 patients of them had CPA. DCTN4 variants were identified in 24% (29/121) CF patients with Pa infection and in only 17% (3/18) CF patients with no Pa infection. Of the patients with CPA, 29% (20/68) had DCTN4 missense variants vs 23% (8/35) in patients without CPA. Interestingly, p.Tyr263Cys tend to be more frequently observed in CF patients with CPA than in patients without CPA (4/68 vs 0/35), and DCTN4 missense variants tend to be more frequent in male CF patients with CPA bearing two class II mutations than in male CF patients without CPA bearing two class II mutations (P = 0.06). Our observations reinforce that DCTN4 missense variants, especially p.Tyr263Cys, may be involved in the pathogenesis of CPA in male CF. |
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"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"O",
"B-T074",
"I-T074",
"O",
"O",
"O",
"O",
"B-T082",
"I-T082",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"O",... | [
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"db_id": null,... | [
"Prevascularized",
"silicon",
"membranes",
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... | Prevascularized silicon membranes for the enhancement of transport to implanted medical devices Recent advances in drug delivery and sensing devices for in situ applications are limited by the diffusion -limiting foreign body response of fibrous encapsulation. In this study, we fabricated prevascularized synthetic device ports to help mitigate this limitation. Membranes with rectilinear arrays of square pores with widths ranging from 40 to 200 μm were created using materials (50 μm thick double-sided polished silicon) and processes (photolithography and directed reactive ion etching) common in the manufacturing of microfabricated sensors. Vascular endothelial cells responded to membrane geometry by either forming vascular tubes that extended through the pore or completely filling membrane pores after 4 days in culture. Although tube formation began to predominate overgrowth around 75 μm and continued to increase at even larger pore sizes, tubes formed at these large pore sizes were not completely round and had relatively thin walls. Thus, the optimum range of pore size for prevascularization of these membranes was estimated to be 75-100 μm. This study lays the foundation for creating a prevascularized port that can be used to reduce fibrous encapsulation and thus enhance diffusion to implanted medical devices and sensors. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater, 104B: 1602-1609, 2016. |
[
"B-T033",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"B-T082",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"B-T033",
"I-T033... | [
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"db_id": "C0231452",
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9... | Seated maximum flexion: An alternative to standing maximum flexion for determining presence of flexion - relaxation? The flexion - relaxation phenomenon (FRP) in standing is a specific and sensitive diagnostic tool for low back pain. Seated flexion as an alternative could be beneficial for certain populations, yet the behavior of the trunk extensors during seated maximum flexion compared to standing flexion remains unclear. Compare FRP occurrences and spine angles between seated and standing flexion postures in three levels of the erector spinae muscles. Thirty-one participants free of back pain performed seated and standing maximum trunk flexion. Electromyographical signals were recorded from the bilateral lumbar (L3), lower-thoracic (T9), and upper-thoracic (T4) erector spinae and assessed for the occurrence of FRP. Spine angles corresponding to FRP onset and cessation were determined, and FRP occurrences and angles were compared between posture and muscle. FRP occurrence was similar in standing and seated maximum flexion across all muscles, with the lumbar muscles showing the greatest consistency. Standing FRP onset and cessation angles were consistently greater than the corresponding seated FRP angles. Considering the similar number of FRP occurrences, seated maximum flexion may constitute an objective criterion for low back pain diagnosis. Future work should seek to confirm the utility of this test in individuals with low back pain. |
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"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
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"O",
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"I-T058",
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"I-T082",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"B-T058",
"O",
"B-T082",
"I-T08... | [
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"db_id": "C024... | [
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9... | The Relationship Between Distance and Post-operative Visit Attendance Following Medical Male Circumcision in Nyanza Province, Kenya To date, there is no research on voluntary medical male circumcision (VMMC) catchment areas or the relationship between distance to a VMMC facility and attendance at a post-operative follow-up visit. We analyzed data from a randomly selected subset of males self-seeking circumcision at one of 16 participating facilities in Nyanza Province, Kenya between 2008 and 2010. Among 1437 participants, 46.7 % attended follow-up. The median distance from residence to utilized facility was 2.98 km (IQR 1.31-5.38). Nearly all participants (98.8 %) lived within 5 km from a facility, however, 26.3 % visited a facility more than 5 km away. Stratified results demonstrated that among those utilizing fixed facilities, greater distance was associated with higher odds of follow-up non-attendance (OR 5.01-10km vs. 0-1km = 1.71, 95 % CI 1.08, 2.70, p = 0.02; OR >10km vs. 0-1 km = 2.80, 95 % CI 1.26, 6.21, p = 0.01), adjusting for age and district of residence. We found 5 km marked the threshold distance beyond which follow-up attendance significantly dropped. These results demonstrate distance is an important predictor of attending follow-up, and this relationship appears to be modified by facility type. |
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"O",
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"I-T033",
"I-T033",
"O",
"O",
"O",
"O",
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"B-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"I-T098",
"O",
"O",
"O",
"O",
"O"... | [
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"db_id": "C0424578",
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"db_id": "C042... | [
"Promoting",
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... | Promoting lifestyle behaviour change and well-being in hospital patients: a pilot study of an evidence-based psychological intervention Lifestyle risk behaviours show an inverse social gradient, clustering in vulnerable groups. We designed and piloted an intervention to address barriers to lifestyle behaviour change among hospital patients. We designed our intervention using effective components of behaviour change interventions informed by psychological theory. Delivered by a health psychologist based at the Royal Free London NHS Foundation Trust, the 4-week intervention included detailed baseline assessment, personalized goal setting, psychological skills development, motivation support and referral to community services. Primary outcomes were feasibility and patient acceptability. We also evaluated changes to health and well-being. From 1 July 2013 to 31 September 2014, 686 patients were referred, 338 (49.3%) attended a first appointment and 172 (25.1%) completed follow-up. Furthermore, 72.1% of attenders were female with the median age 55 years and poor self-reported baseline health. After 4 weeks, self-efficacy, health and well-being scores significantly improved: 63% of lifestyle goals and 89% of health management goals were fully achieved; 58% of referrals to community lifestyle behaviour change services and 79% of referrals to other services (e.g. Citizen's Advice Bureau) were accepted; 99% were satisfied / very satisfied with the service. Our hospital-based intervention was feasible, acceptable and showed preliminary health and well-being gains. |
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"O",
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"O",
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"O",
"O",
"O",
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"B-T204",
"O",
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"B-T168",
"O",
"O",
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"B-T103",
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"O",
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"B-T168",
"O",
"O",
"O",
"O",
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"O",
"O",
"O",
"O",
"... | [
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"db_id": "C0021576",
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"db_id": null,... | [
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... | Combining electrostatic powder with an insecticide: effect on stored - product beetles and on the commodity The opportunity to reduce the amount of pirimiphos-methyl applied to grain by formulating it in an electrostatic powder was investigated. The insecticidal efficacy of pirimiphos-methyl in EC formulation or formulated using electrostatic powder (EP) as an inert carrier was investigated against Sitophilus oryzae (L.), Oryzaephilus surinamensis (L.), Rhyzopertha dominica (F.) and Tribolium confusum Jacquelin du Val. Furthermore, the adhesive properties of EP to rice, corn and wheat, together with the effect on bulk density and bread - and pasta - making properties, were investigated. The results showed that pirimiphos-methyl formulated with EP provided better efficacy against adults when compared with EC formulation for O. surinamensis and T. confusum, but there was no difference for R. dominica. Progeny production was consistently lower in grain treated with the EP formulation than in grain treated with the EC. Tests showed that EP adhered to the kernels for longer on hard wheat than on maize or rice. In most commodities, EP did not alter the bulk density. Finally, the addition of EP did not affect flour - and bread - making properties, nor the pasta -making properties. The results of the present study suggest that an EP could be used to reduce the amount of pirimiphos-methyl applied to grain for effective pest control, with no detrimental effects on grain quality. © 2016 Society of Chemical Industry. |
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"B-T058",
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"O",
"O",
"B-T017",
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"I-T017",
"B-T017",
"I-T017",
"I-T017",
"O",
"O",
"O",
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"B-T017",
"I-T017",
"I-T017",
"I-T017",
"I-T017",
"I-T017",
"O",
"O",
"O",
"O",
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... | [
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"db_id": "C0850292",
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{
"db_id": "C0850292",
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"db_id": "C0447025",
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"db_id": "C0447025",
"db_name": "U... | [
"Radiofrequency",
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... | Radiofrequency ablation of posteroseptal accessory pathways associated with coronary sinus diverticula Posteroseptal accessory pathways may be associated with a coronary sinus (CS) diverticulum. Our purpose was to describe the clinical characteristics, mapping and ablation of these pathways. This was a retrospective study of all patients who underwent ablation of posteroseptal accessory pathways in a single centre. Patients with a diverticulum of the CS or one of its tributaries were included in group I, while the other patients formed group II. Clinical presentation, ablation procedure and outcome were compared between the two groups. A total of 51 patients were included, 16 in group I and 35 in group II. There were no significant differences in age or sex distribution. Atrial fibrillation (AF) and previous unsuccessful ablation were more common in group I. A negative delta wave in lead II was the ECG finding with best sensitivity and specificity for the presence of a diverticulum. A pathway potential was common at the successful site in group I, and the interval between local ventricular electrogram and delta wave onset was shorter (19.5 ± 8 vs 33.1 ± 7.6 ms, p < 0.001). There was a trend toward lower procedural success rate and higher recurrence rate in group I, although this was not significant. CS diverticula should be suspected in patients with manifest posteroseptal accessory pathways who have a previous failed ablation, documented AF or typical electrocardiographic signs. A discrete potential is frequently seen at the successful site, but the local ventricular electrogram is not as early as in other accessory pathways. |
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... | Association of RBP4 levels with increased arterial stiffness in adolescents with family history of type 2 diabetes The aim of this study was to explore the impact of family history of type 2 diabetes (FH2D) on arterial stiffness in young people and its relationship to adipocytokines. This case-control study included 52 adolescents (male / female 28/24) with FH2D (FH2D+) and 40 adolescents (male / female 21/19) without FH2D (FH2D-). Anthropometric measurements, including height, weight, waist circumference (WC), and blood pressure, were obtained. Blood samples were collected, fasting plasma glucose (FPG), serum lipids, Retinol Binding Protein 4 (RBP4), C reactive protein (CRP), adiponectin and visfatin were examined. Brachial-ankle pulse wave velocity (baPWV) was used to evaluate arterial stiffness. Visceral fat area (VFA) was measured by computerized tomography. Compared with FH2D- group, FH2D+ group had a significantly higher oral glucose tolerance test (OGTT) 2-hour insulin, RBP4 and baPWV levels, a lower adiponectin and glucose infusing rate (GIR) (P<0.05). BaPWV was positively correlated with age, systolic blood pressure (SBP), diastolic blood pressure (DBP), 2-hour (OGTT) insulin, RBP4, and VFA, and negatively correlated with GIR in FH2D+ group. After multivariate analysis, age, SBP, RBP4 and VFA maintained an independent association with baPWV in FH2D+ group (P<0.05), while only age, SBP, and VFA were independent predictors of baPWV in FH2D- group (P<0.05). These findings led to the conclusion that RBP4 level was associated with increased arterial stiffness in young subjects with family history of type 2 diabetes. |
[
"O",
"O",
"O",
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"I-T058",
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"B-T082",
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"B-T017",
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"O",
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"B-T033",
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"I-T033",
"O",
"O",
"O",
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"B-T038",
"I-T038",
"B-T082",
"B-T017",
"B-T038",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038... | [
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... | [
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6... | The effect of total hip arthroplasty on sagittal spinal - pelvic-leg alignment and low back pain in patients with severe hip osteoarthritis Sagittal spinopelvic malalignment has been reported in spinal disorders such as low back pain (LBP), and restoration of normal alignment is targeted when treating these disorders. Abnormal sagittal spinal - pelvic-leg alignment has been reported in patients with severe hip osteoarthritis (OA), who have a high prevalence of associated LBP. This prospective longitudinal study aimed to investigate changes in sagittal spinal - pelvic-leg alignment after total hip arthroplasty (THA) in patients with severe hip OA, and whether these changes contribute to LBP relief. Patients undergoing primary THA due to severe unilateral hip OA were recruited. Physical examination and X-ray films were taken to rule out any spinal disorder. Sagittal alignment of pelvis, hip, and spine was analyzed on lateral radiographs taken before (baseline) and 1 year after (follow-up) THA. Functional instruments were completed by patients including: visual analog scale (VAS) for LBP, Roland-Morris Disability Questionnaire (RMDQ), and Harris Hip Score (HHS). Comparisons were carried out at baseline and follow-up, and between patients with and without LBP. The recruited 69 patients showed significantly reduced hip flexion and improved global spinal balance at follow-up compared with baseline. LBP was reported by 39 patients (56.5 %) before surgery; at follow-up, 17 reported complete resolution, while 22 reported significant relief. Significant decreases in VAS and RMDQ scores in lumbar spine and increase in hip HHS were observed. THA in patients with severe hip OA could help correct abnormal sagittal spinal - pelvic-leg alignment and relieve comorbid LBP. Improvements in hip flexion and global spinal balance might be involved in the mechanism of LBP relief. |
[
"O",
"O",
"O",
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"O",
"O",
"O",
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"I-T038",
"O",
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"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
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... | [
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"db_id": null,... | [
"Impact",
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1... | Impact of totally laparoscopic combined management of colorectal cancer with synchronous hepatic metastases on severity of complications: a propensity-score -based analysis Thanks to widespread diffusion of minimally invasive approach in the setting of both colorectal and hepatic surgeries, the interest in combined resections for colorectal cancer and synchronous liver metastases (SCLM) by totally laparoscopic approach (TLA) has increased. Aim of this study was to compare outcome of combined resections for SCLM performed by TLA or by open approach, in a propensity-score-based study. All 25 patients undergoing combined TLA for SCLM at San Raffaele Hospital in Milano were compared in a case-matched analysis with 25 out of 91 patients undergoing totally open approach (TOA group). Groups were matched with 1:2 ratio using propensity scores based on covariates representing disease severity. Main endpoints were postoperative morbidity and long-term outcome. The Modified Accordion Severity Grading System was used to quantify complications. The groups resulted comparable in terms of patients and disease characteristics. The TLA group, as compared to the TOA group, had lower blood loss (350 vs 600 mL), shorter postoperative stay (9 vs 12 days), lower postoperative morbidity index (0.14 vs 0.20) and severity score for complicated patients (0.60 vs 0.85). Colonic anastomosis leakage had the highest fractional complication burden in both groups. In spite of comparable long-term overall survival, the TLA group had better recurrence-free survival. TLA for combined resections is feasible, and its indications can be widened to encompass a larger population of patients, provided its benefits in terms of reduced overall risk and severity of complications, rapid functional recovery and favorable long-term outcomes. |
[
"O",
"O",
"O",
"O",
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"B-T033",
"O",
"O",
"B-T082",
"I-T082",
"O",
"O",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",... | [
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... | Application of an Analytical Solution as a Screening Tool for Sea Water Intrusion Sea water intrusion into aquifers is problematic in many coastal areas. The physics and chemistry of this issue are complex, and sea water intrusion remains challenging to quantify. Simple assessment tools like analytical models offer advantages of rapid application, but their applicability to field situations is unclear. This study examines the reliability of a popular sharp-interface analytical approach for estimating the extent of sea water in a homogeneous coastal aquifer subjected to pumping and regional flow effects and under steady-state conditions. The analytical model is tested against observations from Canada, the United States, and Australia to assess its utility as an initial approximation of sea water extent for the purposes of rapid groundwater management decision making. The occurrence of sea water intrusion resulting in increased salinity at pumping wells was correctly predicted in approximately 60% of cases. Application of a correction to account for dispersion did not markedly improve the results. Failure of the analytical model to provide correct predictions can be attributed to mismatches between its simplifying assumptions and more complex field settings. The best results occurred where the toe of the salt water wedge is expected to be the closest to the coast under predevelopment conditions. Predictions were the poorest for aquifers where the salt water wedge was expected to extend further inland under predevelopment conditions and was therefore more dispersive prior to pumping. Sharp-interface solutions remain useful tools to screen for the vulnerability of coastal aquifers to sea water intrusion, although the significant sources of uncertainty identified in this study require careful consideration to avoid misinterpreting sharp-interface results. |
[
"O",
"O",
"O",
"B-T017",
"O",
"B-T017",
"B-T038",
"I-T038",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"B-T038",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"O"... | [
{
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"db_id... | [
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[
29,
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[
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78,... | The Role of TRAF4 and B3GAT1 Gene Expression in the Food Hypersensitivity and Insect Venom Allergy in Mastocytosis Mastocytosis is an uncommon disease classified as a myeloproliferative neoplasm, however, its symptoms are broad and place patients at crossroads between dermatology, hematology and allergology. Patients with mastocytosis often suffer from symptoms resulting from the activation and release of mediators from the mast cells, such as generalized itching, redness, headache, abdominal cramps, diarrhea, bone pain or arthritis, hypotension and shock. The possible severe, fatal or near fatal reactions caused by food hypersensitivity are reasons for the research focused on marker identification. The aim of the study was to analyse the gene expression differences in mastocytosis patients with and without food and drug hypersensitivity and insect venom allergy (IVA). A total of 57 Caucasian patients with mastocytosis were studied [median age 41.8; range 18-77 years; 15 (26.3 %) males and 42 (73.7 %) females]. Quantitative RT-PCRs of 11 genes plus ribosomal 18S RNA were run. Symptoms of food hypersensitivity were found in 12 patients (21 %), including 3 patients (13 %) with cutaneous mastocytosis (CM), and 9 (28 %) with indolent systemic mastocytosis (ISM). IVA was confirmed in 13 patients (22.8 %) including 6 patients (10.5 %) with CM, and 7 patients (12.3 %) with ISM. Drug hypersensitivity was diagnosed in 10 patients (17.5 %). Significant differences in the gene expression were found for TRAF4 (p = 0.008) in the comparison of the mastocytosis patients with and without concomitant food hypersensitivity. Furthermore significant differences were found in gene expression for B3GAT1 (p = 0.003) in patients with IVA compared to patients without insect sting anaphylaxis in the medical history. The expression of studied genes did not differ according to the presence of drug hypersensitivity. The TRAF4 expression was higher in mastocytosis patients with food hypersensitivity in their medical history, the B3GAT1 expression was lower in mastocytosis patients with IVA in history. |
[
"B-T033",
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"I-T033",
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"B-T033",
"O",
"O",
"O",
"O",
"O",
"O",
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"B-T092",
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"O",
"O",
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"I-T033",
"O",
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"O"... | [
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... | [
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"... | [
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... | Generalized Weakness in a Transplant Patient: A Case Presentation Generalized weakness in transplant patients is a major complaint in tertiary rehabilitation hospitals. The diagnosis and management of generalized weakness in this population pose challenges for physicians. We present the case of a transplant patient with generalized weakness who was eventually diagnosed with calciphylaxis using a multidisciplinary diagnostic approach of electrodiagnostics, vascular study, and skin biopsy. Calciphylaxis is a rare cutaneous disorder that mimics other collagen vascular diseases in its presentation and fulminant course. Physiatrists should be cognizant of calciphylaxis, as it signals a poor prognosis if not correctly diagnosed and treated in a timely manner, with high incidence of sepsis, wound pain, and disability. V. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"B-T082",
"B-T204",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"... | [
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... | [
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98,... | Use of ecoacoustics to determine biodiversity patterns across ecological gradients The variety of local animal sounds characterizes a landscape. We used ecoacoustics to noninvasively assess the species richness of various biotopes typical of an ecofriendly forest plantation with diverse ecological gradients and both nonnative and indigenous vegetation. The reference area was an adjacent large World Heritage Site protected area (PA). All sites were in a global biodiversity hotspot. Our results showed how taxa segregated into various biotopes. We identified 65 singing species, including birds, frogs, crickets, and katydids. Large, natural, protected grassland sites in the PA had the highest mean acoustic diversity (14.1 species / site). Areas covered in nonnative timber or grass species were devoid of acoustic species. Sites grazed by native and domestic megaherbivores were fairly rich (5.1) in acoustic species but none were unique to this habitat type, where acoustic diversity was greater than in intensively managed grassland sites (0.04). Natural vegetation patches inside the plantation mosaic supported high mean acoustic diversity (indigenous forests 7.6, grasslands 8.0, wetlands 9.1), which increased as plant heterogeneity and patch size increased. Indigenous forest patches within the plantation mosaic contained a highly characteristic acoustic species assemblage, emphasizing their complementary contribution to local biodiversity. Overall, acoustic signals determined spatial biodiversity patterns and can be a useful tool for guiding conservation. |
[
"O",
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"I-T038",
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"I-T017",
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"I-T103",
"I-T103",
"O",
"B-T103",
"I-T103",
"I-T103",
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"O",
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"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"O",
"O",
... | [
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... | [
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... | [
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[
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[
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[
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... | Relationship between XspI Site Polymorphisms of LDL-R Gene and Serum IL-2 and IL-10 in Patients with Hypercholesterolemia Relationship has been identified in sporadic reports between polymorphisms and hypercholesterolemia. However, the relationship between inflammatory cytokines and polymorphism of low-density lipoprotein receptor (LDL-R) gene in hypercholesterolemia is unclear. This study aimed to explore the relationship and significance between polymorphisms of LDL-R gene and serum Interleukin-2 (IL-2), IL-10 in patients with hypercholesterolemia. PCR-RFLP and direct DNA sequencing assay were employed to determine polymorphism of LDL-R gene in 900 patients with hypercholesterolemia and 400 healthy cases. ELISA was applied to assay serum concentration of IL-2 and IL-10. Blood lipid indexes were tested in all cases. Compared with the healthy controls, level of IL-2 increased significantly, while IL-10 decreased significantly (P < 0.05). Correlation analysis showed that IL-2 was positively correlated with total cholesterol (TC), LDL-c, and genotype (r = 0.542, 0.410, 0.598, P < 0.05) and negatively correlated with HDL-c (r = -0.352, P < 0.05). Negative relationship also was found between TC, LDL-c, genotype, and IL-10 (r = -0.452, -0.390, -0.613, P < 0.05), and positive correlation between HDL-c and IL-10 (r = 0.398, P < 0.05). Multiple linear regression showed that genotypes and TC were independent factors affecting the levels of IL-2 and IL-10 (P < 0.05). IL-2 and IL-10 were related to gene polymorphisms of LDL-R, which might be involved in the development and progress of hypercholesterolemia. |
[
"O",
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"B-T103",
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"B-T098",
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"B-T082",
"B-T082",
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"O",
"O",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"O",
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"B-T03... | [
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{
... | [
"Low",
"serum",
"vitamin",
"D",
"is",
"associated",
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"higher",
"cortical",
"porosity",
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"elderly",
"men",
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"elderly",
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"mainly",
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"... | [
[
0,
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4,
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10,
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18,
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23,
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[
34,
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39,
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79... | Low serum vitamin D is associated with higher cortical porosity in elderly men Bone loss at peripheral sites in the elderly is mainly cortical and involves increased cortical porosity. However, an association between bone loss at these sites and 25-hydroxyvitamin D has not been reported. To investigate the association between serum levels of 25-hydroxyvitamin D, bone microstructure and areal bone mineral density (BMD) in elderly men. A population -based cohort of 444 elderly men (mean ± SD age 80.2 ± 3.5 years) was investigated. Bone microstructure was measured by high-resolution peripheral quantitative computed tomography, areal BMD by dual-energy X-ray absorptiometry and serum 25-hydroxyvitamin D and parathyroid hormone levels by immunoassay. Mean cortical porosity at the distal tibia was 14.7% higher (12.5 ± 4.3% vs. 10.9 ± 4.1%, P < 0.05) whilst cortical volumetric BMD, area, trabecular bone volume fraction and femoral neck areal BMD were lower in men in the lowest quartile of vitamin D levels compared to the highest. In men with vitamin D deficiency (<25 nmol L(-1)) or insufficiency [25-49 nmol L(-1), in combination with an elevated serum level of parathyroid hormone (>6.8 pmol L(-1))], cortical porosity was 17.2% higher than in vitamin D - sufficient men (P < 0.01). A linear regression model including age, weight, height, daily calcium intake, physical activity, smoking vitamin D supplementation and parathyroid hormone showed that 25-hydroxyvitamin D independently predicted cortical porosity (standardized β = -0.110, R(2) = 1.1%, P = 0.024), area (β = 0.123, R(2) = 1.4%, P = 0.007) and cortical volumetric BMD (β = 0.125, R(2) = 1.4%, P = 0.007) of the tibia as well as areal BMD of the femoral neck (β = 0.102, R(2) = 0.9%, P = 0.04). Serum vitamin D is associated with cortical porosity, area and density, indicating that bone fragility as a result of low vitamin D could be due to changes in cortical bone microstructure and geometry. |
[
"O",
"O",
"O",
"O",
"B-T017",
"O",
"B-T058",
"B-T103",
"B-T103",
"O",
"O",
"B-T074",
"I-T074",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"B-T058",
"B-T103",
"B-T103",
... | [
{
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"db_id": "C382... | [
"Rapid",
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... | [
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30,
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7... | Rapid Fabrication of a Cell - Seeded Collagen Gel -Based Tubular Construct that Withstands Arterial Pressure: Rapid Fabrication of a Gel -Based Media Equivalent Based on plastically compressed cell - seeded collagen gels, we fabricated a small-diameter tubular construct that withstands arterial pressure without prolonged culture in vitro. Specifically, to mimic the microstructure of vascular media, the cell - seeded collagen gel was uniaxially stretched prior to plastic compression to align collagen fibers and hence cells in the gel. The resulting gel sheet was then wrapped around a custom-made multi-layered braided tube to form aligned tubular constructs whereas the gel sheet prepared similarly but without uniaxial stretching formed control constructs. With the braided tube, fluid in the gel construct was further removed by vacuum suction aiming to consolidate the concentric layers of the construct. The construct was finally treated with transglutaminase. Both SEM and histology confirmed the absence of gaps in the wall of the construct. Particularly, cells in the wall of the aligned tubular construct were circumferentially aligned. The enzyme -mediated crosslinking increased burst pressure of both the constructs significantly; the extent of the increase of burst pressure for the aligned tubular construct was greater than that for the control counterpart. Increasing crosslinking left the compliance of the aligned tubular construct unchanged but reduced that of the control construct. Cells remained viable in transglutaminase -treated plastically compressed gels after 6 days in culture. This study demonstrated that by combining stretch-induced fiber alignment, plastic compression, and enzyme -mediated crosslinking, a cell - seeded collagen gel -based tubular construct with potential to be used as vascular media can be made within 3 days. |
[
"B-T038",
"O",
"B-T058",
"O",
"B-T103",
"I-T103",
"O",
"B-T204",
"B-T017",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"B-T058",
"B-T005",
"I-T005",
"O",
"B-T005",
"O",
"O",
"O",
"B-T204",
"O",
"B-T033",
"B-T005",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058"... | [
{
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},
{
"db_id": null,
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{
"db_id": "C0597301",
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{
"db_id": null,
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{
"db_id": "C0017968",
"db_name": "UMLS"
},
{
"db_id": "C0017968",
"db_name": "UMLS"
}... | [
"Expression",
"and",
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... | [
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34,
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47,
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52,
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59,
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[
65,
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66,
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69,
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71,
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... | Expression and Purification of E2 Glycoprotein from Insect Cells (Sf9) for Use in Serology Chikungunya virus (CHIKV) is a mosquito - borne arbovirus which poses a major threat to global public health. Definitive CHIKV diagnosis is crucial, especially in distinguishing the disease from dengue virus, which co-circulates in endemic areas and shares the same mosquito vectors. Laboratory diagnosis is mainly based on serological or molecular approaches. The E2 glycoprotein is a good candidate for serological diagnosis since it is the immunodominant antigen during the course of infection, and reacts with seropositive CHIKV sera. In this chapter, we describe the generation of stable clone Sf9 (Spodoptera frugiperda) cells expressing secreted, soluble, and native recombinant CHIKV E2 glycoprotein. We use direct plasmid expression in insect cells, rather than the traditional technique of generating recombinant baculovirus. This recombinant protein is useful for serological diagnosis of CHIKV infection. |
[
"O",
"B-T033",
"I-T033",
"O",
"B-T033",
"I-T033",
"O",
"B-T033",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"O",
"B-T038",
"B-T062",
"B-T033",
"O",
"O",
"O",
"O",
"B-T091",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0035648",
"db_name": "UMLS"
},
{
"db_id": "C0035648",
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{
"db_id": null,
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},
{
"db_id": "C0038663",
"db_name": "UMLS"
},
{
"db_id": "C0038663",
"db_name": "UMLS"
}... | [
"Acute",
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"factors",
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"suicide",
"attempts",
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"but",
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[
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23,
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31,
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[
40,
43
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44,
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49,
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[
51,
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63,
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72,
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[
77,
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8... | Acute risk factors for suicide attempts and death: prospective findings from the STEP - BD study Suicide is unfortunately common in psychiatric practice, but difficult to predict. The present study sought to assess which clinical symptoms increase in the months before suicidal behavior in a sample of psychiatric outpatients with bipolar disorder. Data from the Systematic Treatment Enhancement Program for Bipolar Disorder (STEP - BD) trial were used. A total of 103 participants who attempted suicide or died by suicide during the trial were included; a 15% random sample of the remaining participants (n = 427) was used as a comparison sample. Linear mixed models in the six months before suicidal behavior were conducted for each of five proposed acute risk factors for suicidal behavior. Participants were assessed using the Clinical Monitoring Form (CMF) at each visit for the following potential acute risk factors for suicidal behavior: suicidal ideation, loss of interest, anxiety, psychomotor agitation, and high-risk behavior. Each of the five symptoms was elevated overall in individuals who engaged in suicidal behavior (p < 0.05). The severity of both suicidal ideation and loss of interest significantly increased in the months before suicidal behavior (p < 0.001). Anxiety demonstrated comparable effect sizes across multiple models. Psychomotor agitation and high-risk behavior were not significantly elevated before suicidal behavior. Suicidal ideation, loss of interest and, to a lesser extent, anxiety may represent acute suicide risk factors up to four months before suicidal behavior in outpatients with bipolar disorder. Further investigation of these potential acute risk factors in prospective analyses is warranted. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"B-T033",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"O",
"O",
"O",
"B-T058",
"I-T058",
... | [
{
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},
{
"db_id": null,
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{
"db_id": null,
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{
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{
"db_id": null,
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{
"db_id": null,
"db... | [
"Measurement",
"of",
"Outcomes",
"of",
"Upper",
"Limb",
"Reconstructive",
"Surgery",
"for",
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"Reconstructive",
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[
0,
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15,
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24,
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[
33,
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[
38,
52
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[
53,
60
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[
61,
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[
65,
76
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[
77,
91
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[
92,
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95,
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... | Measurement of Outcomes of Upper Limb Reconstructive Surgery for Tetraplegia Reconstructive arm/hand surgery for tetraplegia is performed to improve arm/hand function and therefore personal well-being for individuals who accept such elective surgeries. However, changes at an impairment level do not always translate into functional or quality of life changes. Therefore, multiple outcome tools should be used that incorporate sufficient responsiveness to detect changes in arm/hand function, activity and participation, and quality of life of the individuals involved. This narrative review aims to assist clinicians to choose the most appropriate tools to assess the need for reconstructive surgery and to evaluate its outcomes. Our specific objectives are (1) to describe aspects to consider when choosing a measure and (2) to describe the measures advised by an international therapist consensus group established in 2007. All advised measures are appraised in terms of the underlying construct, administration, and clinical relevance to arm/hand reconstructions. Essentially there are currently no criterion standard measures to evaluate the consequences of reconstructive arm/hand surgery. However, with judicious use of available measures it is possible to ensure the questions asked or tasks completed are relevant to the surgical reconstruction (s) undertaken. Further work in this field is required. This would be best met by immediate collaboration between 2 outcome's tool developers and by analysis of pre - and postoperative data already held in various international sites, which would allow further evaluation of the measures already in use, or components thereof. |
[
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"I-T033",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"B-T058",
"O",
"O",
"O"... | [
{
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{
"db_id": null,
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},
{
"db_id": "C2584307",
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{
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{
"db_id": null,
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},
{
"db_id": null,
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{
"db_id": null,... | [
"Factors",
"preventing",
"kneeling",
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"group",
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"educated",
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"one",
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"scoring",
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[
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[
28,
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[
31,
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33,
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[
39,
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[
42,
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[
45,
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[
46,
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[
55,
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[
64,
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7... | Factors preventing kneeling in a group of pre-educated patients post total knee arthroplasty Difficulties in kneeling, one of the poorest scoring functional outcomes post total knee arthroplasty (TKA),have been attributed to a lack of patient education. This is the first study to investigate specific factors affecting a patient's perceived ability to kneel post TKA, following exposure to a preoperative kneeling education session. A cross-sectional study was conducted following TKA with patients who had been educated about kneeling prior to the operation. Patients completed kneeling questionnaires at 6 (n = 115) and 12 (n = 82) months post TKA. In addition to the 12-month kneeling questionnaire, patients also completed the Oxford knee score (OKS) survey. Seventy-two percent of patients perceived they could kneel at 12 months post TKA. Overall, pain and discomfort were the most common factors deterring patients from kneeling. Perceived kneeling ability was the poorest scored outcome on the OKS with patients reporting mild to moderate difficulty with this task. Kneeling scores were strongly correlated with overall knee function scores (R = 0.70), strongly correlated with pain scores (R = 0.45) and weakly correlated with knee stability scores (R = 0.29). When asked about other factors preventing kneeling other than pain or discomfor t, 75 % had reasons unrelated to the knee or TKA. The most common reason was 'problems with the other knee ' (n = 19). Patients in this study were provided with education regarding their kneeling ability post TKA, yet still experienced limitations in perceived kneeling ability post operatively. Contrary to previous research, our study suggests that factors other than patient education affect a patient's perceived kneeling ability post TKA. |
[
"B-T033",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T017",
"O",
"B-T017",
"O",
"B-T017",
"I-T017",
"... | [
{
"db_id": "C0184511",
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{
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{
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"db_id": "C0027868",
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{
"db_id": "C0027868",
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{
... | [
"Improved",
"diagnostic",
"yield",
"of",
"neuromuscular",
"disorders",
"applying",
"clinical",
"exome",
"sequencing",
"in",
"patients",
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"Neuromuscular",
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[
0,
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[
53,
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77,
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[
88,
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91,
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100,
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[
... | Improved diagnostic yield of neuromuscular disorders applying clinical exome sequencing in patients arising from a consanguineous population Neuromuscular diseases (NMDs) include a broad range of disorders affecting muscles, nerves and neuromuscular junctions. Their overlapping phenotypes and heterogeneous genetic nature have created challenges in diagnosis which calls for the implementation of massive parallel sequencing as a candidate strategy to increase the diagnostic yield. In this study, total of 45 patients, mostly offspring of consanguineous marriages were examined using whole exome sequencing. Data analysis was performed to identify the most probable pathogenic rare variants in known NMD genes which led to identification of causal variants for 33 out of 45 patients (73.3%) in the following known genes: CAPN3, Col6A1, Col6A3, DMD, DYSF, FHL1, GJB1, ISPD, LAMA2, LMNA, PLEC1, RYR1, SGCA, SGCB, SYNE1, TNNT1 and 22 novel pathogenic variants were detected. Today, the advantage of whole exome sequencing in clinical diagnostic strategies of heterogeneous disorders is clear. In this cohort, a diagnostic yield of 73.3% was achieved which is quite high compared to the overall reported diagnostic yield of 25% to 50%. This could be explained by the consanguineous background of these patients and is another strong advantage of offering clinical exome sequencing in diagnostic laboratories, especially in populations with high rate of consanguinity. |
[
"O",
"O",
"O",
"B-T058",
"B-T058",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"O"... | [
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{
"db_id": null,
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{
"db_id": "C0001558",
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{
"db_id": "C0021083",
"db_name": "UMLS"
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{
"db_id": null,
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"db_id... | [
"Laser",
"-",
"facilitated",
"epicutaneous",
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... | [
[
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19,
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32,
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46,
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[
49,
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[
52,
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[
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[
62,
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[
70,
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88,
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10... | Laser -facilitated epicutaneous immunotherapy to IgE-mediated allergy Allergen specific immunotherapy has been shown to be the only effective treatment for long-lasting clinical benefit to IgE-mediated allergic diseases, but a fewer than 5% of patients choose the treatment because of inconvenience and a high risk of anaphylaxis. Recently, epicutaneous allergen-specific immunotherapy (EPIT) has proven effective, yet with limitations owing to strong skin reactions. We demonstrate here safer and faster EPIT, named μEPIT, by delivering powdered allergen and adjuvants into many micropores in the epidermis. We fabricated a microarray patch fractionally coated with a powder mixture of ovalbumin (OVA) model allergen, CpG, and 1,25-dihydroxyvitamin D3 (VD3). Topical application of the patch onto laser-microperforated skin resulted in a high level of epidermal delivery while greatly minimizing allergen leakage into circulation system as compared to current subcutaneous immunotherapy (SCIT). Moreover, only three times of μEPIT over two weeks could sufficiently inhibit allergen-specific IgE responses in mice suffering OVA -induced airway hyperresponsivness (AHR), which was unattainable by eight times of SCIT over three weeks. Mechanistically, μEPIT preferably enhanced IgG2a production suggesting TH1-biased immune responses and induced a high level of T-regulatory (Treg) cells against repeated allergen sensitization. The immune tolerance was confirmed by marked reduction in airway wall thickness as well as eosinophil and neutrophil infiltration into the respiratory airway. The μEPIT represents a novel and painless technology to treat IgE-mediated allergic diseases with little local skin reaction and a minimal risk of anaphylaxis. |
[
"O",
"O",
"O",
"B-T098",
"O",
"O",
"O",
"B-T038",
"B-T038",
"O",
"O",
"B-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T06... | [
{
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{
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"db_id": null,... | [
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... | [
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49,
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... | Predicting real - world functional milestones in schizophrenia Schizophrenia is a severe disorder that often causes impairments in major areas of functioning, and most patients do not achieve expected real - world functional milestones. The aim of this study was to identify which variables of demography, illness activity, and functional capacity predict patients ' ability to attain real - world functional milestones. Participants were 235 outpatients, 149 men and 86 women, diagnosed with schizophrenia spectrum disorder. Our results showed that younger patients managed to achieve a higher level of functioning in educational level, marital status, and social contacts. Patients ' functional capacity was primarily associated with educational level and housing situation. We also found that women needed less support regarding housing and obtained a higher level of marital status as compared with men. Our findings demonstrate the importance of considering current symptoms, especially negative symptoms, and remission stability over time, together with age, duration of illness, gender, educational level, and current functional capacity, when predicting patients ' future real - world functioning. We also conclude that there is an advantage in exploring symptoms divided into positive, negative, and general domains considering their probable impact on functional achievements. |
[
"B-T017",
"O",
"B-T017",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T03... | [
{
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{
"db_id": null,
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{
"db_id": "C1412471",
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{
"db_id": "C1412481",
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{
"db_id": "C1412481",
"db_name": "UMLS"
}... | [
"LDLR",
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"central",
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"atherosclerotic",
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[
0,
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4,
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6,
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[
11,
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15,
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20,
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[
26,
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40,
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67,
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80,... | LDLR, ApoB and ApoE genes polymorphisms and classical risk factors in premature coronary artery disease Lipoproteins play a central role in the development of atherosclerotic disease. So, with their ability to affect lipid levels, the LDLR, ApoB and ApoE polymorphisms could be one of the factors influencing development of atherosclerosis. This hypothesis has been tested in different populations with conflicting results. The purpose of the present study was to investigate the association between the LDLR, ApoB and ApoE genes polymorphisms with premature CAD (PCAD) in Egyptians. One hundred thirty-five patients of PCAD and one hundred thirty-two ages and sex matched control subjects were included in the study. LDLR and ApoB genes polymorphisms were analyzed by polymerase chain reaction (PCR). The ApoE genotypes were identified by multiplex amplification refractory mutation system (multi-AMRS). We found that LDLR A(+)A(+) genotype, ApoB X(+) allele and ApoE E4 allele increased the risk of PCAD by 1.8, 2.1 and 12.1 respectively. The present study proved that smoking, metabolic syndrome, ApoB X(+)X(+) genotype and ApoE E4 allele were independent risk factors for the development of PCAD. This is the first study investigate the association between low density lipoprotein receptor, apolipoprotein B and apolipoprotein E genes polymorphisms with PCAD and lipid levels in Egyptians and we concluded that the LDLR A(+)A(+) genotype, ApoB X(+) allele and ApoE E4 allele may be associated with an increased risk for development of PCAD by elevated levels of total cholesterol (TC) and low density lipoprotein (LDLc). The coexistence of CAD risk factors with LDLR A(+)A(+) genotype, ApoB X(+) allele and ApoE E4 allele may increase the risk of the development of PCAD in Egyptian patients. |
[
"B-T017",
"B-T170",
"I-T170",
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"B-T098",
"O",
"O",
"B-T038",
"O",
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"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"B-T062",
"I-T062",
"I-T062",
"O",
"B-T062",
"I-T062",
"I-T062",
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
... | [
{
"db_id": "C0024687",
"db_name": "UMLS"
},
{
"db_id": "C0282574",
"db_name": "UMLS"
},
{
"db_id": "C0282574",
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{
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{
"db_id": "C0043210",
"db_name": "UMLS"
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{
"db_id": null,
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}... | [
"Mandibular",
"kinesiographic",
"pattern",
"of",
"women",
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"chronic",
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34,
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37,
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43,
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48,
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56,
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66,
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82,
93
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... | Mandibular kinesiographic pattern of women with chronic TMD after management with educational and self-care therapies: A double-blind, randomized clinical trial Limited mandibular movements are one of the most important signs of temporomandibular disorders (TMDs) and may cause functional difficulties. The purpose of this double-blind, randomized clinical trial was to evaluate the effect of treatment with only educational or education associated with self-care therapies on the pattern of mandibular movements of women with chronic painful TMDs. Forty-two women were selected and randomly divided into 3 groups, control group (CG, n=13), education group (EG, n=16), and education and self-care group (ESG, n=13), according to the sequence of treatment they received. A kinesiograph device recorded mandibular movements during maximum mouth opening and mastication at baseline (T0) and at 30-day (T1) and 60-day (T2) follow-up. Kinesiographic data were statistically analyzed using 1-way ANOVA, followed by the Bonferroni test for multiple comparisons of means (α=.05). The ESG group demonstrated an improvement in the maximum vertical opening (MVO = 5.1 ±3.4 mm; P=.012) and anteroposterior mandibular movement (MAM) during maximum opening (7.4 ±9.5; P=.019), significantly higher than that of the EG (MVO =1.8 ±3.5 mm; MAM =0.8 ±5.0 mm) and the CG (MVO =0.9 ±3.8 mm; MAM =0.8 ±4.4 mm) after 30 days of follow-up. Moreover, at T1, vertical mandibular movement during mastication was significantly higher in the ESG group (17.4 ±1.7 mm) than in the EG group (15.0 ±2.8, P=.027). No significant differences were found between the women who received treatment with educational and self-care therapies for 60 days and the women who received this treatment for 30 days. In the short-term, education and self-care treatment positively influenced the mandibular movement pattern of women with chronic painful TMDs. |
[
"B-T017",
"I-T017",
"I-T017",
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"I-T017",
"O",
"B-T062",
"B-T017",
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"O",
"O",
"O",
"O",
"O",
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"B-T038",... | [
{
"db_id": "C1537847",
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{
"db_id": "C1537847",
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{
"db_id": "C1537847",
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{
"db_id": null,
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{
"db_id": "C1160454",
"db_name": "UMLS"
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{
"db_id": "C1160454",
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"... | [
[
0,
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36,
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[
39,
44
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[
45,
53
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54,
65
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[
66,
69
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[
70,
78
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82
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83,
... | MiR-211 is epigenetically regulated by DNMT1 mediated methylation and inhibits EMT of melanoma cells by targeting RAB22A MiR-211 has strong inhibitive effects on melanoma cell growth, invasion and metastasis. However, how it is downregulated and whether other genes are involved its downstream regulation in melanoma are not clear. In this study, we firstly verified the expression of miR-211 in melanoma cell lines and observed that its downregulation is associated with increased DNMT1 expression. By performing qRT-PCR and MSP analysis, we confirmed that DNMT1 is negatively correlated with miR-211 expression and can modulate DNA methylation in the promoter region of miR-211. By performing bioinformatics analysis, we found that RAB22A is a possible target of miR-211, which has two broadly conversed binding sites with miR-211 in the 3'UTR. Following dual luciferase assay, qRT-PCR and western blot analysis confirmed the direct binding between miR-211 and RAB22A and the suppressive effect of miR-211 on RAB22A expression. Knockdown of RAB22A increased epithelial properties and impaired mesenchymal properties of the melanoma cells, suggesting that miR-211 modulates epithelial mesenchymal transition (EMT) of melanoma cells via downregulating RAB22A. In summary, the present study firstly demonstrated that DNMT1 mediated promoter methylation is a mechanism of miRNA suppression in melanoma and revealed a new tumor suppressor role of the miR-211 by targeting RAB22A in melanoma. The DNMT1 / miR-211 / RAB22A axis provides a novel insight into the pathogenesis of melanoma, particularly in the EMT process. |
[
"B-T201",
"I-T201",
"I-T201",
"O",
"B-T033",
"O",
"B-T033",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T201",
"I-T2... | [
{
"db_id": "C1305855",
"db_name": "UMLS"
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{
"db_id": "C1305855",
"db_name": "UMLS"
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{
"db_id": "C1305855",
"db_name": "UMLS"
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{
"db_id": null,
"db_name": null
},
{
"db_id": "C0038661",
"db_name": "UMLS"
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{
"db_id": null,
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}... | [
"Body",
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"different",
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[
0,
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10,
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36,
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[
47,
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[
59,
61
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[
62,
72
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[
73,
77
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[
78,
83
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84... | Body mass index and suicide methods Overweight and obesity is associated with lower rates of suicide. However, little is known about the association with different suicide methods. We studied the association between groups of body mass index and suicide methods. We identified all medicolegal autopsy cases with a cause of death due to external causes in Sweden during 1999-2013 (N = 39,368) and included 11,715 suicides and 13,316 accidents or homicides as controls. We applied multinomial regression models adjusted for age, sex, year and season of death. Obesity was associated with suicidal intoxication, OR 1.15 [95% confidence interval (CI) 1.02, 1.30] and negatively associated with all other suicide methods studied. Underweight showed a negative association with suicidal drowning and there was an indication towards a negative association with hanging in men OR 0.81 (95% CI 0.65, 1.01). We conclude that body mass index (BMI) is associated with the choice of suicide method. This may be of importance in a public health perspective, e.g. potential for prevention of intoxications. In the practice of forensic medicine, the physician's level of suspicion may rise if the apparent suicidal method is less common for the individual characteristics of the deceased, such as BMI. |
[
"B-T038",
"I-T038",
"O",
"B-T005",
"O",
"B-T005",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"B-T062",
"I-T062",
"I-T062",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"B-T005",
"I-T005",
"I-T005",
"O",
"B-T005",
"O",
"O",
"B-T005... | [
{
"db_id": "C0338656",
"db_name": "UMLS"
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{
"db_id": "C0338656",
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{
"db_id": null,
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},
{
"db_id": "C0019682",
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{
"db_id": null,
"db_name": null
},
{
"db_id": "C0220847",
"db_name": "UMLS"
}... | [
"Cognitive",
"impairment",
"in",
"HIV",
"and",
"HCV",
"co",
"-",
"infected",
"patients",
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"a",
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"impairment",
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"well",
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"human",
"immunodeficiency",
"virus",... | [
[
0,
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[
10,
20
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[
21,
23
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[
24,
27
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[
28,
31
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[
32,
35
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[
36,
38
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[
38,
39
],
[
39,
47
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[
48,
56
],
[
56,
57
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[
58,
59
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[
60,
70
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[
... | Cognitive impairment in HIV and HCV co-infected patients: a systematic review and meta-analysis Cognitive impairment has been well documented in human immunodeficiency virus (HIV) and hepatitis C virus (HCV) mono-infections. However, in the context of HIV / HCV co-infection the research is more limited. The aim of this systematic review was to describe the characteristics of cognitive impairment in HIV / HCV co-infection and to examine the differences in cognitive performance between HIV / HCV and HIV and HCV mono-infected patients. Of the 437 records initially screened, 24 papers met the inclusion criteria and were included in the systematic review. Four studies were included in the meta-analysis. Most studies indicated that HIV / HCV co-infected patients had a higher level of cognitive impairment than HIV mono-infected patients. Meta-analysis also indicated that HIV mono-infected patients had a significantly lower global deficit score than co-infected patients. The results also indicated that co-infected patients were more likely to be impaired in information processing speed than HIV mono-infected patients. These findings can be challenged by biasing factors such as the small number of included studies, heterogeneity of the samples and a large diversity of methodological procedures. Future research with consistent and comprehensive neuropsychological batteries and covering a greater diversity of risk factors is needed, in order to clarify the effects of both viruses on cognitive function and the mechanisms that underlie these effects. Because cognitive impairments may pose significant challenges to medication adherence, quality of life and overall functioning, such knowledge may have important implications to the planning and implementation of effective interventions aimed at optimising the clinical management of these infections. |
[
"O",
"O",
"B-T058",
"O",
"B-T038",
"B-T017",
"I-T017",
"I-T017",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T170",
"I-T170",
"O",
"B-T170",
"I-T170",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T038",
"B-T017",
"I-T017",
"I-T017",
"O",... | [
{
"db_id": null,
"db_name": null
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{
"db_id": null,
"db_name": null
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{
"db_id": "C0013931",
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{
"db_id": null,
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{
"db_id": "C1512608",
"db_name": "UMLS"
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{
"db_id": "C0752156",
"db_name": "UMLS"
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{
... | [
"Usefulness",
"of",
"Embolization",
"for",
"Iatrogenic",
"Dural",
"Arteriovenous",
"Fistula",
"Associated",
"with",
"Recurrent",
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"Subdural",
"Hematoma",
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"A",
"Case",
"Report",
"and",
"Literature",
"Review",
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"chronic",
"subdural",
"hematom... | [
[
0,
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[
11,
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[
14,
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[
27,
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[
31,
41
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[
42,
47
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[
48,
61
],
[
62,
69
],
[
70,
80
],
[
81,
85
],
[
86,
95
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[
96,
103
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[
104,
112
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[
... | Usefulness of Embolization for Iatrogenic Dural Arteriovenous Fistula Associated with Recurrent Chronic Subdural Hematoma: A Case Report and Literature Review Refractory chronic subdural hematomas due to iatrogenic dural arteriovenous fistulas (dAVFs) are difficult to treat. We report our experience and propose a guideline on basis of a literature review for the usefulness of embolization of middle meningeal artery (MMA) for the treatment of the same. We report a case with right hemiparesis and aphasia 1 month after a fall from a bicycle. Computed tomography scan of the head showed left chronic subdural hematoma, which was evacuated by burr-hole drainage. The postoperative course was complicated by reaccumulation within short period of time. On superselective digital subtraction angiography of MMA, iatrogenic dAVF was found on left side. We embolized successfully it using n-butyl cyanoacrylate after a third irrigation. No reaccumulation found in the postoperative period or at last follow-up. We propose treatment protocol based on our experience and literature review. Refractory chronic subdural hematoma with reaccumulation within a short interval should be subjected to digital subtraction angiography of the MMA. Embolization of ipsilateral MMA is safe, effective, and a useful option for the treatment of iatrogenic dAVF and resolution of hematoma. |
[
"O",
"O",
"B-T037",
"I-T037",
"O",
"B-T033",
"I-T033",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"B-T062",
"I-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"B-T037",
"I-T037",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0458012",
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{
"db_id": "C0458012",
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0035648",
"db_name": "UMLS"
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{
... | [
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"and",
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"crown",
"fractures... | [
[
0,
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[
10,
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[
13,
18
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[
19,
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[
28,
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[
32,
36
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[
37,
44
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[
45,
47
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[
48,
51
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[
52,
59
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[
60,
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[
69,
70
],
[
71,
72
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[
... | Incidence of crown fracture and risk factors in the primary dentition: a prospective longitudinal study Few studies have assessed the incidence and risk factors to crown fractures in preschool children. The aim of this study was to estimate the incidence of crown fracture in the primary dentition over a 1-year follow-up period, identify risk factors, and test the hypothesis that children with previous crown fracture are more prone to experience further cases of crown fracture independently of other risk factors. This study was developed in two phases: cross-sectional and prospective longitudinal study. The cross-sectional study was carried out 261 preschool children. The prospective longitudinal study was carried out 194 children allocated to two groups: exposed group (children with prior exposure to crown fracture) and non - exposed group (children without prior exposure). On both occasions, children were examined for the diagnosis of crown fracture and evaluation of lip coverage and overjet. The parents were interviewed with regard to the socioeconomic indicators. New cases of crown fracture were identified based on the comparison of the two examinations. Data analysis involved Pearson's chi-square test, McNemar's test, and Poisson regression with robust variance. Among the 261 children who participated in the cross-sectional study, 194 were re-examined (65 in the exposed group and 129 in the non - exposed group). The overall incidence of crown fracture was 55.7% (n = 108). The difference in percentage of increased risk of crown fracture in exposed and non - exposed groups was 13.4%. A greater incidence of crown fracture was found in the exposed group (64.6%; P < 0,001). The children exposed (RR: 1.30; 95% CI: 1.01-1.67) had a greater risk of developing new cases of crown fracture in comparison with the non - exposed group. The incidence of crown fracture was high and children with previous crown fracture had a greater risk of suffering new cases of crown fracture during the 1-year follow-up period. |
[
"O",
"O",
"O",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"B-T082",
"O",
"O",
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"O",
"O",
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"I-T038",
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"B-T062",
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"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
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"O",... | [
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... | [
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9... | An Efficient and Reliable Statistical Method for Estimating Functional Connectivity in Large Scale Brain Networks Using Partial Correlation Currently, network-oriented analysis of fMRI data has become an important tool for understanding brain organization and brain networks. Among the range of network modeling methods, partial correlation has shown great promises in accurately detecting true brain network connections. However, the application of partial correlation in investigating brain connectivity, especially in large-scale brain networks, has been limited so far due to the technical challenges in its estimation. In this paper, we propose an efficient and reliable statistical method for estimating partial correlation in large-scale brain network modeling. Our method derives partial correlation based on the precision matrix estimated via Constrained L1-minimization Approach (CLIME), which is a recently developed statistical method that is more efficient and demonstrates better performance than the existing methods. To help select an appropriate tuning parameter for sparsity control in the network estimation, we propose a new Dens-based selection method that provides a more informative and flexible tool to allow the users to select the tuning parameter based on the desired sparsity level. Another appealing feature of the Dens-based method is that it is much faster than the existing methods, which provides an important advantage in neuroimaging applications. Simulation studies show that the Dens-based method demonstrates comparable or better performance with respect to the existing methods in network estimation. We applied the proposed partial correlation method to investigate resting state functional connectivity using rs-fMRI data from the Philadelphia Neurodevelopmental Cohort (PNC) study. Our results show that partial correlation analysis removed considerable between-module marginal connections identified by full correlation analysis, suggesting these connections were likely caused by global effects or common connection to other nodes. Based on partial correlation, we find that the most significant direct connections are between homologous brain locations in the left and right hemisphere. When comparing partial correlation derived under different sparse tuning parameters, an important finding is that the sparse regularization has more shrinkage effects on negative functional connections than on positive connections, which supports previous findings that many of the negative brain connections are due to non-neurophysiological effects. An R package "DensParcorr" can be downloaded from CRAN for implementing the proposed statistical methods. |
[
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"O",
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"O",
"B-T033",
"O",
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"O",
"O",
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"B-T168",
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"O"... | [
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... | [
"Metabolite",
"Profiling",
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"Tomato",
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"with",
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... | Metabolite Profiling of Italian Tomato Landraces with Different Fruit Types Increased interest toward traditional tomato varieties is fueled by the need to rescue desirable organoleptic traits and to improve the quality of fresh and processed tomatoes in the market. In addition, the phenotypic and genetic variation preserved in tomato landraces represents a means to understand the genetic basis of traits related to health and organoleptic aspects and improve them in modern varieties. To establish a framework for this approach, we studied the content of several metabolites in a panel of Italian tomato landraces categorized into three broad fruit type classes (flattened / ribbed, pear / oxheart, round / elongate). Three modern hybrids, corresponding to the three fruit shape typologies, were included as reference. Red ripe fruits were morphologically characterized and biochemically analyzed for their content in glycoalkaloids, phenols, amino acids, and Amadori products. The round / elongate types showed a higher content in glycoalkaloids, whereas flattened types had higher levels of phenolic compounds. Flattened tomatoes were also rich in total amino acids and in particular in glutamic acid. Multivariate analysis of amino acid content clearly separated the three classes of fruit types. Making allowance of the very low number of genotypes, phenotype-marker relationships were analyzed after retrieving single nucleotide polymorphisms (SNPs) among the landraces available in the literature. Sixty-six markers were significantly associated with the studied traits. The positions of several of these SNPs showed correspondence with already described genomic regions and QTLs supporting the reliability of the association. Overall the data indicated that significant changes in quality -related metabolites occur depending on the genetic background in traditional tomato germplasm, frequently according to specific fruit shape categories. Such a variability is suitable to harness association mapping for metabolic quality traits using this germplasm as an experimental population, paving the way for investigating their genetic / molecular basis, and facilitating breeding for quality-related compounds in tomato fruits. |
[
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"I-T038",
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"O",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"B-T103",
"O",
"O",
"B-T103",
"O",
"B-T168",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O... | [
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"db_id": "C0057445",
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82,... | Cross-reactivity features of deoxynivalenol (DON)-targeted immunoaffinity columns aiming to achieve simultaneous analysis of DON and major conjugates in cereal samples Immunoaffinity columns (IACs) are a well-established tool in the determination of regulated mycotoxins in food and feed commodities. However, they also have the potential to become attractive pre-concentration and clean-up materials for the determination of masked (also called modified) mycotoxins, which have been recognised as important contributors to the toxicological hazard deriving from fungal spoilage of goods. However, the information available in the literature concerning the cross-reactivity of DON - IACs against the major conjugates (DON-3-G, 15-AcDON and 3-AcDON) is incomplete and often contradictory. We have carried out a detailed characterisation of the cross-reactivity of the four main IACs brands against DON and its conjugates as well as an assessment of the competition among the analytes. Only one IAC enabled the simultaneous analysis of all relevant DON forms while two missed 15-AcDON and the fourth one missed DON-3-G and 3-AcDON. In the case of the multivalent IAC, the analytes modified at the C-3 position compete for the antibody binding with preference for 3-AcDON (less spatially hindered) while DON-3-G has the more-hindered access to the active sites. Taking into consideration the levels of DON conjugates existing in real samples, the cross-reactivity of one DON - IAC allows a quantitative analysis of all of these analytes. Important but rather neglected aspects such as the continuous supply of IACs with identical characteristics, and of columns which are strictly blank, are also addressed in this paper. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
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"I-T033",
"I-T033",
"O",
"O",
"O",
"O",
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"O",
"B-T033",
"O",
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"I-T033",
"O",
"O",
"O",
"O",
"O",
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"Improving",
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... | Improving Early Identification and Ongoing Care of Children With Autism Spectrum Disorder Poor adherence to recommended screening for autism spectrum disorder (ASD) and pediatricians ' lack of confidence in providing care for children with ASD reflect quality gaps in primary care. This study aimed to increase the proportion of toddlers screened for ASD and improve physicians ' self-efficacy in providing care to children with ASD. Twenty-six Utah primary care practices participated in a 3 to 6 month learning collaborative (LC) to improve identification and ongoing care of children with ASD. Monthly chart audits assessed whether an ASD screening tool was administered at 18- and 24- month visits. Physicians completed pre-LC and post-LC surveys to assess changes in self-efficacy in providing care and changes in perceived barriers to implementation of screening and caring for children with ASD. Before the LC, 15% of 18- and 24- month visits had documented ASD screening, compared with 91% during the last month of the LC (P < .001). This rate of ASD screening was sustained 4 years after the LC by most practices. Compared with survey responses before the LC, physicians reported significant improvement in their ability to care for children with ASD and decreases in their perceived barriers to screening and caring for children with ASD. The LC was effective in increasing and sustaining recommended ASD screening of toddlers and improving physicians ' perceived self-efficacy in caring for children with ASD. Improving primary care screening, skills, and knowledge may improve the timing of diagnosis, initiation of treatment, quality of care, and outcomes for children with ASD. |
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"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
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"O",
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"O",
"O",
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"B-T062",
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"I-T062",
"O",
"O",
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"O",
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"O",
"O",
"O",
"O",
"O",
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... | Describing Self-Care Self-Efficacy: Definition, Measurement, Outcomes, and Implications The pragmatic utility method of concept analysis was used to explore the usefulness of the concept self-care self-efficacy. Empirical studies across disciplines published between 1996 and 2015 were used as data. A data matrix was developed. Analytical questions and responses were derived from the data to understand patterns, develop new knowledge and achieve synthesis. Usefulness of the concept is contingent on how it is defined and measured. Self-care self-efficacy is associated with performance of self-care activities and positive health outcomes in diverse populations. Research can guide development of targeted interventions to increase patients ' self-care self-efficacy, thus reducing costs, and assisting people to achieve optimal health. |
[
"O",
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"O",
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"B-T038",
"I-T038",
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"O",
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"O",
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"B-T103",
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"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
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... | [
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"db_id... | [
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[
0,
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35,
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50,
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9... | Dynamics of intestinal metabolites and morphology in response to necrotic enteritis challenge in broiler chickens Despite the relatively small contribution to metabolizable energy that volatile fatty acids (VFAs) provide in chickens, these organic acids have been reported to play beneficial roles in the gastrointestinal tract (GIT) of birds, for example, inhibition of the growth of some pathogenic bacteria. However, information regarding the dynamics of these metabolites in the GIT of chickens is still scarce, especially under disease conditions such as necrotic enteritis (NE). Here, we investigated the dynamics of VFAs and lactic acid, and intestinal morphology in response to NE predisposing factors, that is, excessive dietary fishmeal and Eimeria inoculation, and causative agent Clostridium perfringens producing NetB toxin. The experiment was designed in a 2 × 2 × 2 factorial arrangement of treatments with or without: fishmeal feeding, Eimeria inoculation and C. perfringens challenge. The results showed that these factors significantly influenced composition and concentration of VFAs and lactic acids, pH and histomorphometry in one way or another. These changes may be important for the onset of NE or only the synergetic responses to micro environmental stress. Eimeria appeared to be more important than fishmeal in predisposing birds to NE, thus the application of Eimeria in NE challenge provides more consistent success in inducing the disease. The metabolic responses to various adverse factors such as excessive dietary fishmeal and Eimeria infection are complex. Thus, intensive efforts are required to better understand NE so as to achieve the control of the disease in the absence of antibiotics. |
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63,... | Ehlers-Danlos syndrome The Ehlers-Danlos syndromes (EDSs) were originally described by Ehlers in Denmark and Danlos in Paris in 1898 and 1908, respectively. They had both published individual case studies in which the common factor was laxity of ligaments leading to joint hypermobility and hyperextensibility of the skin. The choice of the name of this eponymous disease had been made by Dr Parkes Weber, an eminent London physician in the 1930s, who had a penchant for eponymous diseases, having had no less than seven attributed to himself, at least in part. Unfortunately, this was before the age of a computerised literature search, and Parkes Weber had inadvertently overlooked the very first description of EDS which had been made by Tchernabogov, a Russian dermatologist, whose description was published in 1891 and remains one of the best descriptions of EDS in the literature. |
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... | Assessment of laparoscopic stomach preserving surgery with sentinel basin dissection versus standard gastrectomy with lymphadenectomy in early gastric cancer -A multicenter randomized phase III clinical trial (SENORITA trial) protocol Along with the marked increase in early gastric cancer (EGC) in the Eastern countries, there has been an effort to adopt the sentinel node concept in EGC to preserve gastric function and reduce the occurrence of postoperative complications. Based on promising results from a previous quality control study, this prospective multicenter randomized controlled phase III clinical trial aims to elucidate the oncologic safety of laparoscopic stomach-preserving surgery with sentinel basin dissection (SBD) compared to a standard laparoscopic gastrectomy. This trial is an investigator-initiated, open-label, multicenter randomized controlled phase III trial with a non-inferiority design. Patients diagnosed with a single lesion of clinical stage T1N0M0 gastric adenocarcinoma, with a diameter of 3 cm or less are eligible for the present study. A total of 580 patients (290 per group) will be randomized to either laparoscopic stomach-preserving surgery with SBD or standard surgery. The primary end-point is 3-year disease-free survival (DFS) and the secondary endpoints include postoperative morbidity and mortality, quality of life, 5-year DFS, and overall survival. Qualified investigators who completed the prior quality control study are exclusively allowed to participate in this phase III clinical trial. The proposed trial is expected to verify whether laparoscopic stomach-preserving surgery with SBD achieves similar oncologic outcomes and improved quality of life compared to a standard gastrectomy in EGC patients. This study was registered at the NIH ClinicalTrial.gov database (NCT01804998) on March 4th, 2013. |
[
"O",
"O",
"B-T103",
"O",
"B-T038",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T017",
"O",
"O",
"B-T082",
"I-T082",
"I-T082",
"B-T017",
"I-T017",
"I-T017",
"I-T017",
"I-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"B-T103",
"O",
"O",
... | [
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"db_id... | [
"Association",
"of",
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"with",
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"and",
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"2",
"Diabetes",
"Based",
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... | Association of Metabolites with Obesity and Type 2 Diabetes Based on FTO Genotype The single nucleotide polymorphism rs9939609 of the gene FTO, which encodes fat mass and obesity -associated protein, is strongly associated with obesity and type 2 diabetes (T2D) in multiple populations; however, the underlying mechanism of this association is unclear. The present study aimed to investigate FTO genotype -dependent metabolic changes in obesity and T2D. To elucidate metabolic dysregulation associated with disease risk genotype, genomic and metabolomic datasets were recruited from 2,577 participants of the Korean Association REsource (KARE) cohort, including 40 homozygous carriers of the FTO risk allele (AA), 570 heterozygous carriers (AT), and 1,967 participants carrying no risk allele (TT). A total of 134 serum metabolites were quantified using a targeted metabolomics approach. Through comparison of various statistical methods, seven metabolites were identified that are significantly altered in obesity and T2D based on the FTO risk allele (adjusted p < 0.05). These identified metabolites are relevant to phosphatidylcholine metabolic pathway, and previously reported to be metabolic markers of obesity and T2D. In conclusion, using metabolomics with the information from genome-wide association studies revealed significantly altered metabolites depending on the FTO genotype in complex disorders. This study may contribute to a better understanding of the biological mechanisms linking obesity and T2D. |
[
"B-T170",
"O",
"O",
"B-T091",
"O",
"O",
"B-T091",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T091",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C0600644",
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},
{
"db_id": null,
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{
"db_id": null,
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"db_id": "C0033873",
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id... | [
"Anthology",
"of",
"Venezuelan",
"psychiatry",
"Reception",
"of",
"Psychiatry",
"in",
"Venezuela",
"since",
"the",
"19th",
"Century",
"to",
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"late",
"20th",
"Century",
"merits",
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"approach",
".",
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"following",
"work",
"proposes",
"t... | [
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82,
86
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87,
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... | Anthology of Venezuelan psychiatry Reception of Psychiatry in Venezuela since the 19th Century to the late 20th Century merits a historical approach. The following work proposes to research some of the very origins of Venezuelan psychiatry and its possible influence on contemporary mental health practice. Through documental research, the early works of local authors from the 19th Century through 20th Century finals: Carlos Arvelo, Lisandro Alvarado, Francisco Herrera Luque, Jose Luis Vethencourt and Jose Solanes, are subjected to study. This journey illustrates a descriptive panoramic view which allows to better comprenhend the current state of our psychiatry. In a brief introduction the most important events are described, since the arrival of Pinel's ideas, followed by the early research paperworks published and the beginnings of the academic teachings of this specialty in Venezuela and displaying the main contemporary research groups thorough the country. |
[
"O",
"O",
"B-T082",
"B-T098",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"B-T098",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T097",
"O",
"O",
"O",
"O",
... | [
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{
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{
"db_id": "C1705920",
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{
... | [
"How",
"variation",
"between",
"individuals",
"affects",
"species",
"coexistence",
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"coexistence",
",",
... | [
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0,
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[
4,
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50,
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62,
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[
71,
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75,
82
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[
83,
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86,
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[
96,
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... | How variation between individuals affects species coexistence Although the effects of variation between individuals within species are traditionally ignored in studies of species coexistence, the magnitude of intraspecific variation in nature is forcing ecologists to reconsider. Compelling intuitive arguments suggest that individual variation may provide a previously unrecognised route to diversity maintenance by blurring species - level competitive differences or substituting for species - level niche differences. These arguments, which are motivating a large body of empirical work, have rarely been evaluated with quantitative theory. Here we incorporate intraspecific variation into a common model of competition and identify three pathways by which this variation affects coexistence: (1) changes in competitive dynamics because of nonlinear averaging, (2) changes in species ' mean interaction strengths because of variation in underlying traits (also via nonlinear averaging) and (3) effects on stochastic demography. As a consequence of the first two mechanisms, we find that intraspecific variation in competitive ability increases the dominance of superior competitors, and intraspecific niche variation reduces species - level niche differentiation, both of which make coexistence more difficult. In addition, individual variation can exacerbate the effects of demographic stochasticity, and this further destabilises coexistence. Our work provides a theoretical foundation for emerging empirical interests in the effects of intraspecific variation on species diversity. |
[
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"B-T103",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"B-T103",
"B-T038",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038"... | [
{
"db_id": "C1524026",
"db_name": "UMLS"
},
{
"db_id": "C1524026",
"db_name": "UMLS"
},
{
"db_id": null,
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{
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"db_id": null,
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{
"db_id": null,
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{
"db_id... | [
"Intracellular",
"Metabolism",
"of",
"α",
",",
"β",
"-",
"Unsaturated",
"Carbonyl",
"Compounds",
",",
"Acrolein",
",",
"Crotonaldehyde",
"and",
"Methyl",
"Vinyl",
"Ketone",
",",
"Active",
"Toxicants",
"in",
"Cigarette",
"Smoke",
":",
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"Glut... | [
[
0,
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14,
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25,
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[
28,
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[
29,
30
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[
30,
31
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[
31,
32
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[
32,
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[
44,
52
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[
53,
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[
62,
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64,
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72,
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... | Intracellular Metabolism of α,β-Unsaturated Carbonyl Compounds, Acrolein, Crotonaldehyde and Methyl Vinyl Ketone, Active Toxicants in Cigarette Smoke: Participation of Glutathione Conjugation Ability and Aldehyde-Ketone Sensitive Reductase Activity The major toxicants in cigarette smoke, α,β-unsaturated aldehydes, such as acrolein (ACR) and crotonaldehyde (CA), and α,β-unsaturated ketone, methyl vinyl ketone (MVK), are known to form Michael-type adducts with glutathione (GSH) and consequently cause intracellular GSH depletion, which is involved in cigarette smoke - induced cytotoxicity. We have previously clarified that exposure to cigarette smoke extract (CSE) of a mouse melanoma cell culture medium causes rapid reduction of intracellular GSH levels, and that the GSH - MVK adduct can be detected by LC/MS analysis while the GSH - CA adduct is hardly detected. In the present study, to clarify why the GSH - CA adduct is difficult to detect in the cell medium, we conducted detailed investigation of the structures of the reaction products of ACR, CA, MVK and CSE in the GSH solution or the cell culture medium. The mass spectra indicated that in the presence of the cells, the GSH - CA and GSH - ACR adducts were almost not detected while their corresponding alcohols were detected. On the other hand, both the GSH - MVK adducts and their reduced products were detected. In the absence of the cells, the reaction of GSH with all α,β-unsaturated carbonyls produced only their corresponding adducts. These results show that the GSH adducts of α,β-unsaturated aldehydes, CA and ACR, are quickly reduced by certain intracellular carbonyl reductase(s) and excreted from the cells, unlike the GSH adduct of α,β-unsaturated ketone, MVK. Such a difference in reactivity to the carbonyl reductase might be related to differences in the cytotoxicity of α,β-unsaturated aldehydes and ketones. |
[
"B-T058",
"O",
"B-T058",
"B-T017",
"I-T017",
"B-T038",
"B-T017",
"I-T017",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"B-T082",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"... | [
{
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{
"db_id": "C1510438",
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{
"db_id": "C0230812",
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},
{
"db_id": "C0230812",
"db_name": "UMLS"
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{
"db_id": "C0007613",
"db_name": "U... | [
"Strategies",
"for",
"Assaying",
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"Membrane",
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"Late",
"endosomal",
"organelles",
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... | [
[
0,
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11,
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60,
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65,
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86,
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91,
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101,
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... | Strategies for Assaying Lysosomal Membrane Permeabilization Late endosomal organelles have an acidic pH and contain hydrolytic enzymes to degrade cargo delivered either from the extracellular environment by endocytosis or from within the cell itself by autophagy. In the event of lysosomal membrane permeabilization (LMP), the contents of late endosomes and lysosomes can be released into the cytosol and then initiate apoptosis. Compounds that can trigger LMP are therefore candidates for the induction of apoptosis, in particular in anticancer therapy. Alternatively, drug-delivery systems, such as nanoparticles, can have side effects that can include LMP, which has toxic consequences for the cells. To determine when, to what extent, and with what consequences LMP occurs is therefore of paramount importance for the evaluation of new potentially LMP - inducing compounds. In this introduction, we provide an overview of some basic assays for assessing LMP, such as staining with lysosomotropic dyes and measurement of cysteine cathepsin activity, and discuss additional strategies for the detection of the release of endogenous lysosomal molecules or preloaded exogenous tracers into the cytosol. |
[
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"B-T017",
"I-T017",
"I-T017",
"I-T017",
"I-T017",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"B-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"B-T038",
"O",
"O",
"B-T017... | [
{
"db_id": null,
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{
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{
"db_id": "C0596290",
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{
"db_id": "C0596290",
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{
"db_id": null,
"db_name": null
},
{
"db_id": "C0073870",
"db_name": "UMLS"
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{
... | [
"Stimulation",
"of",
"cell",
"proliferation",
"by",
"glutathione",
"monoethyl",
"ester",
"in",
"aged",
"bone",
"marrow",
"stromal",
"cells",
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"associated",
"with",
"the",
"assistance",
"of",
"TERT",
"gene",
"expression",
"and",
"telomerase",
"activity",
"The"... | [
[
0,
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[
12,
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15,
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20,
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[
34,
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37,
48
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[
49,
58
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[
59,
64
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[
65,
67
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[
68,
72
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[
73,
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[
78,
84
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[
85,
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... | Stimulation of cell proliferation by glutathione monoethyl ester in aged bone marrow stromal cells is associated with the assistance of TERT gene expression and telomerase activity The proliferation and differentiation potential of aged bone marrow stromal cells (BMSCs) are significantly reduced. In order to improve the performance of the aged BMSCs, these cells were treated with 2 mM glutathione monoethyl ester (GSH-MEE) for 24 h. Proliferation rate, telomerase activity, telomere length, and differentiation to cholinergic neuron-like cells (CNLCs) were observed to increase. Though, the expression level of telomerase reverse transcriptase gene increased, but CTC1 and TEN1 genes from Ctc1-Stn1-Ten1 complex encoding proteins with regulatory function significantly decreased. Trypan blue exclusion assay was used to analyze the proliferation and, while telomere length, its several related gene expressions, and telomerase activity were measured using the real time reverse transcription-polymerase chain reaction and polymerase chain reaction enzyme-linked immunosorbent assay techniques, respectively. CNLCs differentiation potential was evaluated by estimating the percentage of choline acetyltransferase immunereactive cells .The results suggested that GSH-MEE could improve aged rat BMSC properties and would be of potential benefit for enhancing the performance of aged people's BMSCs. |
[
"B-T168",
"I-T168",
"I-T168",
"O",
"B-T204",
"O",
"O",
"O",
"B-T168",
"B-T082",
"O",
"O",
"B-T082",
"O",
"B-T082",
"I-T082",
"O",
"B-T082",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"B-T168",
"I-T168"... | [
{
"db_id": "C0032099",
"db_name": "UMLS"
},
{
"db_id": "C0032099",
"db_name": "UMLS"
},
{
"db_id": "C0032099",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0016832",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
}... | [
"Wild",
"food",
"plants",
"and",
"fungi",
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"mycophilous",
"Tibetan",
"community",
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"Tewo",
"County",
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"Gansu",
",",
"China",
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"to",
"investigate",
"knowledge",
"and... | [
[
0,
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[
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[
32,
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[
35,
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[
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69,
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72,
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80... | Wild food plants and fungi used in the mycophilous Tibetan community of Zhagana (Tewo County, Gansu, China) The aim of the study was to investigate knowledge and use of wild food plants and fungi in a highland valley in the Gannan Tibetan Autonomous Region on the north-eastern edges of the Tibetan Plateau. Field research was carried out in four neighbouring villages in a mountain valley of the Diebu (Tewo) county, surrounded by spruce forests. The study consisted of 30 interviews with single informants, or group interviews (altogether 63 informants). Apart from collecting voucher specimens, we also identified fungi using DNA barcoding. We recorded the use of 54 species of vascular plants. We also recorded the use of 22 mushroom taxa, which made up the largest category of wild foods. Fruits formed the largest category of food plants, with 21 species, larger than the wild greens category, which consisted of 20 species eaten after boiling or frying and 7 as raw snacks. We also recorded the alimentary use of 10 species of edible flowers and 3 species with underground edible organs. On average, 20.8 edible taxa were listed per interview (median - 21). The most listed category of wild foods was green vegetables (mean - 7.5 species, median - 8 species), but fruits and mushrooms were listed nearly as frequently (mean - 6.3, median - 6 and mean - 5.8, - median 6 respectively). Other category lists were very short, e.g., flowers (mean - 1.3, median - 1) and underground edible parts (mean - 0.7, median - 1). Wild vegetables are usually boiled and/or fried and served as side-dishes, or their green parts are eaten as snacks during mountain treks (e.g., peeled rhubarb shoots). Wild fruits are mainly collected by children and eaten raw, they are not stored for further use. The most widely used wild staple foods are Potetilla anserina roots, an important ceremonial food served on such occasions as New Year or at funerals. They are boiled and served with sugar and butter. The most important famine plants remembered by people are the aerial bulbils of Persicaria vivipara. Flowers are used as children's snacks - their nectar is sucked. The number of wild taxa eaten in the studied valley is similar to that of other Tibetan areas. The structure of wild food plant taxa is also very typical for Tibetan speaking areas (e.g., the use of rhubarb shoots, Potentilla anserina, Persicaria vivipara). The studied community show a high level of mycophilia. |
[
"O",
"O",
"B-T082",
"B-T058",
"I-T058",
"O",
"B-T017",
"I-T017",
"I-T017",
"B-T058",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"B-T082",
"B-T058",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"I-T017",
"O",
"B-T058",
"I-T058",
"O",
"O",
... | [
{
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{
"db_id": "C0018670",
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{
"db_id": "C0439775",
"db_name": "UMLS"
},
{
"db_id": "C0439775",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Comparison",
"of",
"Head",
"Elevation",
"Protocols",
"Following",
"Femoral",
"Artery",
"Sheath",
"Removal",
"After",
"Coronary",
"Angiography",
"To",
"compare",
"2",
"standard",
"protocols",
"for",
"head",
"elevation",
"following",
"removal",
"of",
"a",
"femoral",
... | [
[
0,
10
],
[
11,
13
],
[
14,
18
],
[
19,
28
],
[
29,
38
],
[
39,
48
],
[
49,
56
],
[
57,
63
],
[
64,
70
],
[
71,
78
],
[
79,
84
],
[
85,
93
],
[
94,
105
],
[
... | Comparison of Head Elevation Protocols Following Femoral Artery Sheath Removal After Coronary Angiography To compare 2 standard protocols for head elevation following removal of a femoral artery sheath after coronary angiography and their effects on bleeding complications and reported levels of back pain. One protocol involved flat supine bed rest; the other allowed progressive head elevation. A prospective comparative study of 80 adult patients undergoing coronary angiography via the femoral approach. The Numeric Rating Scale was used as the measure of reported pain. No bleeding complications occurred in either group. Both groups had very low mean pain scores. Repeated- measures analysis demonstrated that the experience of pain differed significantly over time by location (F5,70 = 3.864, P = .004), with a notable decrease in pain scores more than 1 hour after sheath removal at the location that used the progressive head elevation protocol. Patients ' satisfaction scores after discharge did not differ significantly between the 2 groups. Patients with a history of chronic back pain had consistently higher pain scores, but those pain scores did not differ significantly by location (or protocol). It appears that using a progressive head - elevation protocol within the first 3 hours after diagnostic angiography is not associated with an increased risk of bleeding complications at the access site and warrants further exploration in the mitigation of back pain associated with prolonged supine bed rest. |
[
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0013203",
"db_name": "UMLS"
},
{
"db_id": "C0013203",
"db_name": "UMLS"
},
{
"db_id": "C0013203",
"db_name": "UMLS"
},
{
... | [
"Heterogeneous",
"Mechanisms",
"of",
"Primary",
"and",
"Acquired",
"Resistance",
"to",
"Third",
"-",
"Generation",
"EGFR",
"Inhibitors",
"To",
"identify",
"novel",
"mechanisms",
"of",
"resistance",
"to",
"third",
"-",
"generation",
"EGFR",
"inhibitors",
"in",
"pat... | [
[
0,
13
],
[
14,
24
],
[
25,
27
],
[
28,
35
],
[
36,
39
],
[
40,
48
],
[
49,
59
],
[
60,
62
],
[
63,
68
],
[
68,
69
],
[
69,
79
],
[
80,
84
],
[
85,
95
],
[
... | Heterogeneous Mechanisms of Primary and Acquired Resistance to Third-Generation EGFR Inhibitors To identify novel mechanisms of resistance to third-generation EGFR inhibitors in patients with lung adenocarcinoma that progressed under therapy with either AZD9291 or rociletinib (CO-1686). We analyzed tumor biopsies from seven patients obtained before, during, and/or after treatment with AZD9291 or rociletinib (CO-1686). Targeted sequencing and FISH analyses were performed, and the relevance of candidate genes was functionally assessed in in vitro models. We found recurrent amplification of either MET or ERBB2 in tumors that were resistant or developed resistance to third-generation EGFR inhibitors and show that ERBB2 and MET activation can confer resistance to these compounds. Furthermore, we identified a KRAS(G12S) mutation in a patient with acquired resistance to AZD9291 as a potential driver of acquired resistance. Finally, we show that dual inhibition of EGFR /MEK might be a viable strategy to overcome resistance in EGFR-mutant cells expressing mutant KRAS CONCLUSIONS: Our data suggest that heterogeneous mechanisms of resistance can drive primary and acquired resistance to third-generation EGFR inhibitors and provide a rationale for potential combination strategies. Clin Cancer Res; 1-11. ©2016 AACR. |
[
"B-T103",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"B-T031",
"O",
"B-T038",
"I-T038",
"O",
"B-T103",
"O",
"O",
"B-T103",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"... | [
{
"db_id": "C1609241",
"db_name": "UMLS"
},
{
"db_id": "C0037083",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Nax",
"signaling",
"evoked",
"by",
"an",
"increase",
"in",
"[",
"Na",
"+",
"]",
"in",
"CSF",
"induces",
"water",
"intake",
"via",
"EET",
"-",
"mediated",
"TRPV4",
"activation",
"Water",
"-",
"intake",
"behavior",
"is",
"under",
"the",
"control",
"of",
"... | [
[
0,
3
],
[
4,
13
],
[
14,
20
],
[
21,
23
],
[
24,
26
],
[
27,
35
],
[
36,
38
],
[
39,
40
],
[
40,
42
],
[
42,
43
],
[
43,
44
],
[
45,
47
],
[
48,
51
],
[
5... | Nax signaling evoked by an increase in [Na+] in CSF induces water intake via EET -mediated TRPV4 activation Water-intake behavior is under the control of brain systems that sense body-fluid conditions at sensory circumventricular organs (sCVOs); however, the underlying mechanisms have not yet been elucidated in detail. Nax is a sodium (Na(+)) level sensor in the brain, and the transient receptor potential vanilloid (TRPV) channels, TRPV1 and TRPV4, have been proposed to function as osmosensors. We herein investigated voluntary water intake immediately induced after an intracerebroventricular (icv) administration of a hypertonic NaCl solution in TRPV1-, TRPV4-, Nax-, and their double-gene knockout (KO) mice. The induction of water intake by TRPV1 - KO mice was normal, whereas that by TRPV4 - KO and Nax - KO mice was significantly less than that by WT mice. Water intake by Nax / TRPV4 - double KO mice was similar to that by the respective single KO mice. When TRPV4 activity was blocked with a specific antagonist HC-067047, water intake by WT mice was significantly reduced, whereas that by TRPV4 - KO and Nax - KO mice was not. Similar results were obtained with the administration of miconazole, which inhibits the biosynthesis of epoxyeicosatrienoic acids (EETs), endogenous agonists for TRPV4, from arachidonic acid (AA). Icv injection of hypertonic NaCl with AA or 5,6-EET restored water intake by Nax - KO mice to the WT level, but not that by TRPV4 - KO mice. These results suggest that the Na(+) signal generated in Nax - positive glial cells leads to the activation of TRPV4 - positive neurons in sCVOs in order to stimulate water intake by using EETs as gliotransmitters. |
[
"O",
"O",
"O",
"B-T204",
"I-T204",
"I-T204",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"I-T204",
"I-T204",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0887965",
"db_name": "UMLS"
},
{
"db_id": "C0887965",
"db_name": "UMLS"
},
{
"db_id": "C0887965",
"db_name": "UMLS"
},
{
... | [
"An",
"Accessible",
"and",
"Pragmatic",
"Experimental",
"Model",
"of",
"Nonalcoholic",
"Fatty",
"Liver",
"Disease",
"BACKGROUND",
"There",
"is",
"no",
"convenient",
"cheap",
"pragmatic",
"experimental",
"model",
"for",
"Nonalcoholic",
"Fatty",
"Liver",
"Disease",
"(... | [
[
0,
2
],
[
3,
13
],
[
14,
17
],
[
18,
27
],
[
28,
40
],
[
41,
46
],
[
47,
49
],
[
50,
62
],
[
63,
68
],
[
69,
74
],
[
75,
82
],
[
83,
93
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[
94,
99
],
[
1... | An Accessible and Pragmatic Experimental Model of Nonalcoholic Fatty Liver Disease BACKGROUND There is no convenient cheap pragmatic experimental model for Nonalcoholic Fatty Liver Disease (NAFLD)/ Nonalcoholic Steatohepatitis (NASH). Our objective was to create a pragmatic model of NAFLD / NASH. METHODS Sprague-Dawley rats were fed a high-fat, high sugar homemade diet ad libitum for seven weeks. The high-fat, high sugar diet included 59% of energy derived from fat, 30% from carbohydrates, and 11% from protein. Serum levels of fasting glucose, triglyceride, cholesterol, liver enzymes, insulin, and hepatic tumor necrosis factor-alpha (TNF-α) gene expression were determined. Hepatic histology was examined by H&E stain. RESULTS Rats fed the high-fat, high sugar diet developed hepatic steatosis, and a moderate inflammation, which was associated with increased serum levels of liver enzymes, glucose, insulin, triglyceride, cholesterol, and hepatic TNF-α gene expression. CONCLUSION This rat model resembles the key features of human NAFLD / NASH and provides a simple pragmatic experimental model for elucidating the disease prevention and treatment. |
[
"O",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"B-T058",
"I-T058",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"B-T038",
"I-T038",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0576773",
"db_name": "UMLS"
},
{
"db_id": null,... | [
"Comparison",
"of",
"the",
"Effects",
"of",
"Subcutaneous",
"Versus",
"Continuous",
"Infusion",
"of",
"Heparin",
"on",
"Key",
"Inflammatory",
"Parameters",
"Following",
"Sepsis",
"Sepsis",
"is",
"the",
"result",
"of",
"the",
"interaction",
"between",
"inflammatory",... | [
[
0,
10
],
[
11,
13
],
[
14,
17
],
[
18,
25
],
[
26,
28
],
[
29,
41
],
[
42,
48
],
[
49,
59
],
[
60,
68
],
[
69,
71
],
[
72,
79
],
[
80,
82
],
[
83,
86
],
[
... | Comparison of the Effects of Subcutaneous Versus Continuous Infusion of Heparin on Key Inflammatory Parameters Following Sepsis Sepsis is the result of the interaction between inflammatory mediators and coagulation pathway. Unfractionated heparin may play a role as an anti-inflammatory agent beyond its anticoagulatory effect in sepsis. As a result, it may cause reduction in organ failure rate in patients with sepsis due to its impact on both inflammatory and coagulation process. The aim of this study was to evaluate the anti-inflammatory effects of heparin in sepsis. Plasma plasminogen activator inhibitor-1 (PAI-1) as an inflammatory mediator and urinary necoutrophil gelatinase-associated lipocalin (NGAL) as a marker of kidney injury were investigated. This prospective, randomized controlled trial was conducted in a 32- bed intensive care unit. Thirty patients with sepsis were randomized to receive heparin infusion of 500 units/hour or 5000 units of heparin three times a day, subcutaneously. The plasma level of PAI-1 and urinary level of NGAL were determined at day 0, 2 and 7. The infusion group had a lower plasma PAI-1 level compared to the subcutaneous group at day 7 (11.3 ± 1.6 vs. 16.5 ± 4.2; P = 0.003). The urinary NGAL level was lower in the infusion group at day 2 (131.3 ± 11.9 vs. 151.2 ± 20.6; P = 0.014); however, at day 7 the NGAL level was decreased in the subcutaneous group as much as the infusion group and there was no significant difference between the two groups. There was no significant difference in the acute physiology and chronic health evaluation (APACHE) II and sequential organ failure assessment (SOFA) scores between the two groups at day 0, 2 and 7. Low-dose heparin infusion compared to subcutaneous heparin can decrease the plasma PAI-1 and urinary NGAL levels more rapidly. It can be related to anti-inflammatory effects of heparin, which may be more prominent in infusion route. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"B-T033",
"O",
"B-T170",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"B-T098",
"O",
"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db... | [
"The",
"Spreading",
"of",
"Social",
"Energy",
":",
"How",
"Exposure",
"to",
"Positive",
"and",
"Negative",
"Social",
"News",
"Affects",
"Behavior",
"Social",
"news",
",",
"unlike",
"video",
"games",
"or",
"TV",
"programs",
",",
"conveys",
"real",
"-",
"life"... | [
[
0,
3
],
[
4,
13
],
[
14,
16
],
[
17,
23
],
[
24,
30
],
[
30,
31
],
[
32,
35
],
[
36,
44
],
[
45,
47
],
[
48,
56
],
[
57,
60
],
[
61,
69
],
[
70,
76
],
[
7... | The Spreading of Social Energy: How Exposure to Positive and Negative Social News Affects Behavior Social news, unlike video games or TV programs, conveys real-life interactions. Theoretically, social news in which people help or harm each other and violate rules should influence both prosocial and violation behaviors. In two experiments, we demonstrated the spreading effects of social news in a social interaction context emphasizing social conventions and a nonsocial interaction context emphasizing moral norms. Across the two studies, the results showed that positive social news increased cooperation (decreased defection) but had no effect on cheating, whereas negative social news increased cheating but with no change in cooperation (or defection). We conclude that there is a spreading impact of positive social news in the conventional norm domain and of negative social news in the moral norm domain. |
[
"O",
"B-T170",
"I-T170",
"O",
"O",
"B-T038",
"I-T038",
"B-T062",
"B-T082",
"I-T082",
"O",
"B-T091",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0237604",
"db_name": "UMLS"
},
{
"db_id": "C0237604",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0025353",
"db_name": "UMLS"
},
{
... | [
"Using",
"Evolutionary",
"Theory",
"to",
"Guide",
"Mental",
"Health",
"Research",
"Evolutionary",
"approaches",
"to",
"medicine",
"can",
"shed",
"light",
"on",
"the",
"origins",
"and",
"etiology",
"of",
"disease",
".",
"Such",
"an",
"approach",
"may",
"be",
"e... | [
[
0,
5
],
[
6,
18
],
[
19,
25
],
[
26,
28
],
[
29,
34
],
[
35,
41
],
[
42,
48
],
[
49,
57
],
[
58,
70
],
[
71,
81
],
[
82,
84
],
[
85,
93
],
[
94,
97
],
[
9... | Using Evolutionary Theory to Guide Mental Health Research Evolutionary approaches to medicine can shed light on the origins and etiology of disease. Such an approach may be especially useful in psychiatry, which frequently addresses conditions with heterogeneous presentation and unknown causes. We review several previous applications of evolutionary theory that highlight the ways in which psychiatric conditions may persist despite and because of natural selection. One lesson from the evolutionary approach is that some conditions currently classified as disorders (because they cause distress and impairment) may actually be caused by functioning adaptations operating " normally " (as designed by natural selection). Such conditions suggest an alternative illness model that may generate alternative intervention strategies. Thus, the evolutionary approach suggests that psychiatry should sometimes think differently about distress and impairment. The complexity of the human brain, including normal functioning and potential for dysfunctions, has developed over evolutionary time and has been shaped by natural selection. Understanding the evolutionary origins of psychiatric conditions is therefore a crucial component to a complete understanding of etiology. |
[
"B-T038",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T204",
"I-T204",
"B-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"O",... | [
{
"db_id": "C0017262",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0031843",
"db_name": "UMLS"
},
{
"db_id": "C0031843",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Transcriptomic",
"and",
"Physiological",
"Responses",
"of",
"the",
"Green",
"Microalga",
"Chlamydomonas",
"reinhardtii",
"during",
"Short",
"-",
"Term",
"Exposure",
"to",
"Subnanomolar",
"Methylmercury",
"Concentrations",
"The",
"effects",
"of",
"short",
"-",
"term",... | [
[
0,
14
],
[
15,
18
],
[
19,
32
],
[
33,
42
],
[
43,
45
],
[
46,
49
],
[
50,
55
],
[
56,
65
],
[
66,
79
],
[
80,
91
],
[
92,
98
],
[
99,
104
],
[
104,
105
],
[
... | Transcriptomic and Physiological Responses of the Green Microalga Chlamydomonas reinhardtii during Short-Term Exposure to Subnanomolar Methylmercury Concentrations The effects of short-term exposure to subnanomolar methyl-mercury (MeHg) concentrations, representative of contaminated environments, on the microalga Chlamydomonas reinhardtii were assessed using both physiological end points and gene expression analysis. MeHg bioaccumulated and induced significant increase of the photosynthesis efficiency, while the algal growth, oxidative stress, and chlorophyll fluorescence were unaffected. At the molecular level, MeHg significantly dysregulated the expression of genes involved in motility, energy metabolism, lipid metabolism, metal transport, and antioxidant enzymes. Data suggest that the cells were able to cope with subnanomolar MeHg exposure, but this tolerance resulted in a significant cost to the cell energy and reserve metabolism as well as ample changes in the nutrition and motility of C. reinhardtii. The present results allowed gaining new insights on the effects and uptake mechanisms of MeHg at subnanomolar concentrations in aquatic primary producers. |
[
"O",
"O",
"B-T062",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0035171",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0475358",
"db_name": "UMLS"
},
{
"db_id... | [
"Hierarchical",
"Targeting",
"Strategy",
"for",
"Enhanced",
"Tumor",
"Tissue",
"Accumulation",
"/",
"Retention",
"and",
"Cellular",
"Internalization",
"Targeted",
"delivery",
"of",
"therapeutic",
"agents",
"is",
"an",
"important",
"way",
"to",
"improve",
"the",
"the... | [
[
0,
12
],
[
13,
22
],
[
23,
31
],
[
32,
35
],
[
36,
44
],
[
45,
50
],
[
51,
57
],
[
58,
70
],
[
71,
72
],
[
73,
82
],
[
83,
86
],
[
87,
95
],
[
96,
111
],
[
... | Hierarchical Targeting Strategy for Enhanced Tumor Tissue Accumulation / Retention and Cellular Internalization Targeted delivery of therapeutic agents is an important way to improve the therapeutic index and reduce side effects. To design nanoparticles for targeted delivery, both enhanced tumor tissue accumulation / retention and enhanced cellular internalization should be considered simultaneously. So far, there have been very few nanoparticles with immutable structures that can achieve this goal efficiently. Hierarchical targeting, a novel targeting strategy based on stimuli responsiveness, shows good potential to enhance both tumor tissue accumulation / retention and cellular internalization. Here, the recent design and development of hierarchical targeting nanoplatforms, based on changeable particle sizes, switchable surface charges and activatable surface ligands, will be introduced. In general, the targeting moieties in these nanoplatforms are not activated during blood circulation for efficient tumor tissue accumulation, but re-activated by certain internal or external stimuli in the tumor microenvironment for enhanced cellular internalization. |
[
"B-T033",
"I-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"B-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"... | [
{
"db_id": "C0034079",
"db_name": "UMLS"
},
{
"db_id": "C0034079",
"db_name": "UMLS"
},
{
"db_id": "C0034079",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Subsolid",
"pulmonary",
"nodule",
"morphology",
"and",
"associated",
"patient",
"characteristics",
"in",
"a",
"routine",
"clinical",
"population",
"To",
"determine",
"the",
"presence",
"and",
"morphology",
"of",
"subsolid",
"pulmonary",
"nodules",
"(",
"SSNs",
")",... | [
[
0,
8
],
[
9,
18
],
[
19,
25
],
[
26,
36
],
[
37,
40
],
[
41,
51
],
[
52,
59
],
[
60,
75
],
[
76,
78
],
[
79,
80
],
[
81,
88
],
[
89,
97
],
[
98,
108
],
[
... | Subsolid pulmonary nodule morphology and associated patient characteristics in a routine clinical population To determine the presence and morphology of subsolid pulmonary nodules (SSNs) in a non-screening setting and relate them to clinical and patient characteristics. A total of 16,890 reports of clinically obtained chest CT (06/2011 to 11/2014, single-centre) were searched describing an SSN. Subjects with a visually confirmed SSN and at least two thin-slice CTs were included. Nodule volumes were measured. Progression was defined as volume increase exceeding the software interscan variation. Nodule morphology, location, and patient characteristics were evaluated. Fifteen transient and 74 persistent SSNs were included (median follow-up 19.6 [8.3-36.8] months). Subjects with an SSN were slightly older than those without (62 vs. 58 years; p = 0.01), but no gender predilection was found. SSNs were mostly located in the upper lobes. Women showed significantly more often persistent lesions than men (94 % vs. 69 %; p = 0.002). Part-solid lesions were larger (1638 vs. 383 mm(3); p < 0.001) and more often progressive (68 % vs. 38 %; p = 0.02), compared to pure ground-glass nodules. Progressive SSNs were rare under the age of 50 years. Logistic regression analysis did not identify additional nodule parameters of future progression, apart from part-solid nature. This study confirms previously reported characteristics of SSNs and associated factors in a European, routine clinical population. • SSNs in women are significantly more often persistent compared to men. • SSN persistence is not associated with age or prior malignancy. • The majority of (persistent) SSNs are located in the upper lung lobes. • A part-solid nature is associated with future nodule growth. • Progressive solitary SSNs are rare under the age of 50 years. |
[
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"B-T033",
"O",
"B-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"B-T062",
"B-T170",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",... | [
{
"db_id": "C3899514",
"db_name": "UMLS"
},
{
"db_id": "C3899514",
"db_name": "UMLS"
},
{
"db_id": "C3899514",
"db_name": "UMLS"
},
{
"db_id": "C3899514",
"db_name": "UMLS"
},
{
"db_id": "C3899514",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": ... | [
"Dynamic",
"CT",
"myocardial",
"perfusion",
"imaging",
"identifies",
"early",
"perfusion",
"abnormalities",
"in",
"diabetes",
"and",
"hypertension",
":",
"Insights",
"from",
"a",
"multicenter",
"registry",
"To",
"identify",
"patients",
"with",
"early",
"signs",
"of"... | [
[
0,
7
],
[
8,
10
],
[
11,
21
],
[
22,
31
],
[
32,
39
],
[
40,
50
],
[
51,
56
],
[
57,
66
],
[
67,
80
],
[
81,
83
],
[
84,
92
],
[
93,
96
],
[
97,
109
],
[
... | Dynamic CT myocardial perfusion imaging identifies early perfusion abnormalities in diabetes and hypertension: Insights from a multicenter registry To identify patients with early signs of myocardial perfusion reduction, a reference base for perfusion measures is needed. To analyze perfusion parameters derived from dynamic computed tomography perfusion imaging (CTPI) in patients with suspected coronary artery disease (CAD), and relationship with risk factors. In this multicenter study, coronary CT angiography (cCTA) and dynamic CTPI were performed by second-generation dual-source CT in patients suspected of CAD. Risk factors were collected from hospital records. Patients with visual perfusion defects on CTPI, previous coronary intervention, or missing risk factor details were excluded. This analysis included 98 patients (mean age ± standard deviation [SD], 59.0 ± 8.6yrs; 73 male). Global measures of left ventricular myocardial blood flow (MBF), myocardial blood volume (MBV) and volume transfer constant (K(trans)) were calculated. Mean MBF was 139.3 ± 31.4 mL/100 mL/min, MBV 19.1 ± 2.7 mL/100 mL, and Ktrans 85.0 ± 17.5 mL/100 mL/min. No significant differences in perfusion parameters were found by gender or age category. Hypertension and diabetes mellitus resulted in lower perfusion parameters (hypertension vs normotension: MBV 18.5 ± 3.0 vs 19.7 ± 2.3 mL/100 mL and K(trans) 82.0 ± 18.0 vs 89.0 ± 16.0, p < 0.05; diabetes vs no diabetes: MBF 128.5 ± 31.5 vs 144.0 ± 30.5 mL/100 mL/min and MBV 17.9 ± 2.4 vs 19.4 ± 2.8 mL/100 mL, p < 0.05). In patients with hyperlipidemia, MBF was higher (146.8 ± 34.4 vs 130.7 ± 24.3 mL/100 mL/min, p < 0.05). Smoking and family history did not show perfusion parameter differences. Dynamic CTPI identifies early perfusion disturbances in conditions like diabetes and hypertension. With further standardization, absolute perfusion measures may improve CAD risk stratification in patients without visual perfusion defects. |
[
"B-T038",
"O",
"O",
"O",
"B-T103",
"O",
"B-T103",
"O",
"B-T038",
"I-T038",
"O",
"B-T204",
"I-T204",
"O",
"B-T204",
"I-T204",
"O",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T168",
"O",
"B-T168",
"I-T168",
"O",
"B-T168",
"O"... | [
{
"db_id": "C0009240",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0163159",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Cognition",
"Enhancing",
"Activity",
"of",
"Sulforaphane",
"Against",
"Scopolamine",
"Induced",
"Cognitive",
"Impairment",
"in",
"Zebra",
"Fish",
"(",
"Danio",
"rerio",
")",
"Several",
"epidemiological",
"studies",
"have",
"shown",
"that",
"consumption",
"of",
"lar... | [
[
0,
9
],
[
10,
19
],
[
20,
28
],
[
29,
31
],
[
32,
44
],
[
45,
52
],
[
53,
64
],
[
65,
72
],
[
73,
82
],
[
83,
93
],
[
94,
96
],
[
97,
102
],
[
103,
107
],
[
... | Cognition Enhancing Activity of Sulforaphane Against Scopolamine Induced Cognitive Impairment in Zebra Fish (Danio rerio) Several epidemiological studies have shown that consumption of large quantities of vegetables especially cruciferous vegetables (Broccoli and Brussels sprouts) can protect against chronic diseases. Sulforaphane, an isothiocynate found in cruciferous vegetables has been demonstrated to have neuroprotective effects in several experimental paradigms. This study was undertaken to examine the effect of sulforaphane on cognitive impairment in zebra fish model using a novel method of fear conditioning. Initially, the normal behaviour of zebra fishes was studied in light-dark tank for 10 min daily for 10 days. Fishes were then divided into seven groups of twelve in each. Group I served as normal, group II served as fear conditioned control, group III and group IV were sulforaphane (25 µM/L) and piracetam (200 mg/L) treated respectively. Group V served as scopolamine (400 µM/L) induced memory impairment fishes. Group VI and VII were sulforaphane (25 µM/L) and piracetam (200 mg/L) treated scopolamine induced memory impairment groups respectively. In normal behavioural analysis, fishes preferred to stay in dark compartment. The average number of entries into the dark and time spent in dark were significantly more. Fishes in group II to VII were individually subjected to fear conditioning passive avoidance task and evaluated for learned task memory. It was observed that the average number of entries into dark and time spent in dark were significantly decreased. After exposure to respective treatment fishes in group III to VII were subjected to cognitive evaluation. There was no significant difference in cognition of group III and IV fishes exposed to sulforaphane and piracetam alone respectively. Fishes exposed to scopolamine showed a significant cognitive impairment. Sulforaphane exposure prior to scopolamine significantly retained the memory of learned task. These findings suggest that sulforaphane might be a promising therapeutic agent for cognitive enhancement in Alzheimer's disease. |
[
"O",
"O",
"B-T103",
"O",
"B-T103",
"O",
"B-T103",
"B-T058",
"O",
"B-T201",
"B-T033",
"O",
"B-T033",
"I-T033",
"I-T033",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"B-T103",
"O",
"B-T103",
"B-T058",
"O",
"O",
"B-T033",
"O",
"B-... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0127306",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0246957",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Value",
"of",
"MDM2",
",",
"CDK4",
"and",
"SATB2",
"immunohistochemistry",
"in",
"histologic",
"diagnosis",
"of",
"low",
"-",
"grade",
"osteosarcoma",
"To",
"investigate",
"the",
"value",
"of",
"combined",
"application",
"of",
"MDM2",
",",
"CDK4",
"and",
"SAT... | [
[
0,
5
],
[
6,
8
],
[
9,
13
],
[
13,
14
],
[
15,
19
],
[
20,
23
],
[
24,
29
],
[
30,
50
],
[
51,
53
],
[
54,
64
],
[
65,
74
],
[
75,
77
],
[
78,
81
],
[
81,... | Value of MDM2, CDK4 and SATB2 immunohistochemistry in histologic diagnosis of low-grade osteosarcoma To investigate the value of combined application of MDM2, CDK4 and SATB2 immunohistochemistry in pathological diagnosis of low-grade osteosarcoma. Forty-seven cases of low grade osteosarcoma, including low grade central osteosarcoma (n=20) and parosteal osteosarcoma (n=27), were selected from Shanghai Jiaotong University Affiliated the Sixth People's Hospital. The clinical, radiography and histopathology were reviewed. The sensitivity and specificity of MDM2, CDK4 and SATB2 immunohistochemistry in the diagnosis of low-grade osteosarcoma were assessed along with an evaluation of their expressions in fibrous dysplasia, desmoplastic fibroma, low-grade fibrosarcoma and other fibrous tumors. Low-grade osteosarcoma had protracted clinical course, occurring mostly in elder adults and mainly involving long bones. Radiographic studies showed that low-grade central osteosarcoma had a mainly malignant lytic presentation, however about 5/18 of t umors overlapping with intermediate and benign bone diseases, while parosteal osteosarcoma was characterized by a densely sclerotic malignant appearance. Histologically, low-grade osteosarcoma s were characterized by well-differentiated spindle tumor cells, various mature tumor bones and an aggressive growth pattern. The positive expression rates of MDM2 and CDK4 in low-grade osteosarcoma were 74.5% and 55.3%, respectively. Eighty-three percent of low-grade osteosarcoma expressed one or both markers. Low-grade osteosarcoma and fibrous dysplasia were both positive for SATB2, while desmoplastic fibroma, low-grade fibrosacoma and other fibrous tumors were negative for SATB2. Accurate diagnosis of low-grade osteosarcoma should be based on combination of clinical presentation, imaging and histopathology, with immunohistochemistry as a diagnostic adjunct. Positive immunostaining for CDK4 and/or MDM2 supports the diagnosis of low-grade osteosarcoma, but the negative one does not rule out such lesion. The negative expression of SATB2 is helpful to exclude fibrous tumors originating from bone with the exception of fibrous dysplasia. |
[
"O",
"O",
"B-T091",
"B-T062",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"I-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T062",
"I-T062",
"O",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"O"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0887950",
"db_name": "UMLS"
},
{
"db_id": "C0035168",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0041573",
"db_name": "UMLS"
},
{
... | [
"Biobank",
"and",
"Genomic",
"Research",
"in",
"Uganda",
":",
"Are",
"Extant",
"Privacy",
"and",
"Confidentiality",
"Regimes",
"Adequate",
"?",
"Not",
"many",
"African",
"countries",
"have",
"been",
"able",
"to",
"develop",
"a",
"robust",
"system",
"for",
"reg... | [
[
0,
7
],
[
8,
11
],
[
12,
19
],
[
20,
28
],
[
29,
31
],
[
32,
38
],
[
38,
39
],
[
40,
43
],
[
44,
50
],
[
51,
58
],
[
59,
62
],
[
63,
78
],
[
79,
86
],
[
8... | Biobank and Genomic Research in Uganda: Are Extant Privacy and Confidentiality Regimes Adequate? Not many African countries have been able to develop a robust system for regulating health research within their respective jurisdictions, particularly in the realm of biobanking and genomics. This is not without reason. Aside from underdevelopment and all that it entails or perhaps in consequence thereof, countries in the region have been unable to make significant strides in medical research. But there are exceptions. Amongst the few seeming success stories is Uganda. Nonetheless, although the country has developed what appears to be a functional framework to govern genomic research and biobanking, the consistency of key provisions with international standards, especially those pertaining to privacy of research participants and confidentiality of their health information, is not at all clear. Yet, making this determination - the main objective of this article - is critical in determining the adequacy of protection available to human research subjects in the country. |
[
"O",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"B-T098",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"O",
"B-T... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0175566",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,... | [
"Impact",
"of",
"a",
"Casino",
"Opening",
"on",
"Gambling",
"Behaviors",
"of",
"People",
"Engaged",
"in",
"Methadone",
"Maintenance",
"This",
"study",
"examined",
"gambling",
"behavior",
"in",
"the",
"context",
"of",
"a",
"newly",
"opening",
"casino",
",",
"co... | [
[
0,
6
],
[
7,
9
],
[
10,
11
],
[
12,
18
],
[
19,
26
],
[
27,
29
],
[
30,
38
],
[
39,
48
],
[
49,
51
],
[
52,
58
],
[
59,
66
],
[
67,
69
],
[
70,
79
],
[
80... | Impact of a Casino Opening on Gambling Behaviors of People Engaged in Methadone Maintenance This study examined gambling behavior in the context of a newly opening casino, comparing disordered gamblers to non-disordered gamblers, in a population of individuals involved in methadone maintenance treatment. Disordered gamblers (N = 50) and non-disordered gamblers (N = 50) were surveyed before and after the opening of a new casino on gambling behaviors, substance use, and psychological symptoms. No statistically significant changes in gambling behaviors were observed for disordered gamblers or non-disordered gamblers across time points; however, non-disordered gamblers demonstrated non-significant increases in horse and dog race betting, electronic games, and casino table games. As expected, disordered gamblers were found to spend significantly more money on electronic games and casino table games (p < 0.05) and demonstrated higher rates of drug use and impulsivity than non-disordered gamblers. The introduction of a new casino did not appear to have a major impact on gambling behaviors of individuals attending methadone maintenance treatment, though the non-significant increases in gambling among non-disordered gamblers may indicate that this population is preferentially impacted by the opening of a new casino. Future investigation into the longer term effects of opening a new casino on this population may be warranted. |
[
"O",
"O",
"B-T038",
"O",
"B-T033",
"I-T033",
"O",
"O",
"O",
"O",
"B-T038",
"B-T033",
"O",
"B-T058",
"I-T058",
"B-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"B-T037",
"O",
"B-T037",
"I-T037",
"I-T037",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T01... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0948163",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C3806166",
"db_name": "UMLS"
},
{
"db_id": "C3806166",
"db_name": "UMLS"
},
{
... | [
"Association",
"between",
"Leukoaraiosis",
"and",
"Poor",
"Outcome",
"is",
"not",
"due",
"to",
"Reperfusion",
"Inefficiency",
"after",
"Intravenous",
"Thrombolysis",
"Leukoaraiosis",
"(",
"LA",
")",
"is",
"associated",
"with",
"structural",
"and",
"functional",
"cer... | [
[
0,
11
],
[
12,
19
],
[
20,
33
],
[
34,
37
],
[
38,
42
],
[
43,
50
],
[
51,
53
],
[
54,
57
],
[
58,
61
],
[
62,
64
],
[
65,
76
],
[
77,
89
],
[
90,
95
],
[
... | Association between Leukoaraiosis and Poor Outcome is not due to Reperfusion Inefficiency after Intravenous Thrombolysis Leukoaraiosis (LA) is associated with structural and functional cerebrovascular impairment, which may compromise the capacity of ischemic tissue to maximize reperfusion after intravenous thrombolysis (IVT). We aimed to determine whether severe LA is correlated with reperfusion inefficiency, which contributes to infarct growth and poor functional outcome. We analyzed data from our consecutive acute ischemic stroke (AIS) patients who had acquired baseline and 24-h follow-up diffusion- and perfusion-weighted imaging. Reperfusion was defined as reduction of ≥70 % of hypoperfusion lesion at 24 h from baseline. Severe LA was defined as Fazekas score 2 or 3 on FLAIR images. We investigated the relationship between severity of LA and reperfusion status. Multivariate statistical analysis was carried out for modeling the independent predictors of reperfusion, infarct growth, and functional outcome. Finally, 79 patients were included, among them 30 (37.97 %) had severe LA. Reperfusion was observed in 41 (51.89 %) patients, the proportion of reperfusion was very similar in patients with and without severe LA (53.33 vs 51.02 %, p = 1.000). Large artery occlusion was the only independent unfavorable predictor for reperfusion (OR = 0.202, 95 % confidence interval, 0.060-0.673; p = 0.014). Multiple linear regression analysis revealed that severe LA was independently associated with infarct growth (standardized coefficients = 0.191, p = 0.040). Severe LA was also an independent predictor of poor outcome (mRS ≥ 3) (OR = 4.004, 95 % confidence interval, 1.267-12.656, p = 0.018) after adjusting for reperfusion and baseline severity of stroke. Severe LA was associated with infarct growth and poor outcome independent of reperfusion status, which may expand the notion that LA contributes the intrinsic vulnerability of brain tissue to acute ischemic insults. The burden of LA may not serve as an imaging indicator of reperfusion inefficiency after IVT for AIS patients. |
[
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"B-T204",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
... | [
{
"db_id": "C1336767",
"db_name": "UMLS"
},
{
"db_id": "C1336767",
"db_name": "UMLS"
},
{
"db_id": null,
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id... | [
"RNA",
"topoisomerase",
"is",
"prevalent",
"in",
"all",
"domains",
"of",
"life",
"and",
"associates",
"with",
"polyribosomes",
"in",
"animals",
"DNA",
"Topoisomerases",
"are",
"essential",
"to",
"resolve",
"topological",
"problems",
"during",
"DNA",
"metabolism",
... | [
[
0,
3
],
[
4,
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],
[
18,
20
],
[
21,
30
],
[
31,
33
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[
34,
37
],
[
38,
45
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[
46,
48
],
[
49,
53
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[
54,
57
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[
58,
68
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[
69,
73
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[
74,
87
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[
8... | RNA topoisomerase is prevalent in all domains of life and associates with polyribosomes in animals DNA Topoisomerases are essential to resolve topological problems during DNA metabolism in all species. However, the prevalence and function of RNA topoisomerases remain uncertain. Here, we show that RNA topoisomerase activity is prevalent in Type IA topoisomerases from bacteria, archaea, and eukarya. Moreover, this activity always requires the conserved Type IA core domains and the same catalytic residue used in DNA topoisomerase reaction; however, it does not absolutely require the non-conserved carboxyl-terminal domain (CTD), which is necessary for relaxation reactions of supercoiled DNA. The RNA topoisomerase activity of human Top3β differs from that of Escherichia coli topoisomerase I in that the former but not the latter requires the CTD, indicating that topoisomerases have developed distinct mechanisms during evolution to catalyze RNA topoisomerase reactions. Notably, Top3β proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli and yeast lack the association. The Top3β - polyribosome association requires TDRD3, which directly interacts with Top3β and is present in animals but not bacteria or yeast. We propose that RNA topoisomerases arose in the early RNA world, and that they are retained through all domains of DNA -based life, where they mediate mRNA translation as part of polyribosomes in animals. |
[
"B-T170",
"I-T170",
"B-T082",
"I-T082",
"O",
"B-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"O",
"B-T170",
"O",
"O",
"B-T170",
"B-T082",
"I-T082",
"O",
"B-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T007",
"I-T0... | [
{
"db_id": "C1547277",
"db_name": "UMLS"
},
{
"db_id": "C1547277",
"db_name": "UMLS"
},
{
"db_id": "C2348746",
"db_name": "UMLS"
},
{
"db_id": "C2348746",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1027928",
"db_name": "U... | [
"First",
"Draft",
"Genome",
"Sequence",
"of",
"Staphylococcus",
"condimenti",
"F",
"-",
"2T",
"This",
"report",
"describes",
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"draft",
"genome",
"sequence",
"of",
"S",
".",
"condimenti",
"strain",
"F",
"-",
"2",
"(",
"T",
")",
"(",
"DSM",
"11674",
... | [
[
0,
5
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[
6,
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12,
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19,
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],
[
28,
30
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[
31,
45
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[
46,
56
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[
57,
58
],
[
58,
59
],
[
59,
61
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[
62,
66
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[
67,
73
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[
74,
83
],
[
8... | First Draft Genome Sequence of Staphylococcus condimenti F-2T This report describes the draft genome sequence of S. condimenti strain F-2(T) (DSM 11674), a potential starter culture. The genome assembly comprised 2,616,174 bp with 34.6% GC content. To the best of our knowledge, this is the first documentation that reports the whole-genome sequence of S. condimenti. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T074",
"I-T074",
"O",
"O",
"O",
"O",
"B-T074",
"B-T038",
"B-T074",
"O",
"B-T033",
"I-T033",
"O",
"O",
"O",
"O",
"B-T038",
"B-T170",
"O",
"B-T097",
"O",
"O",
"B-T170",
"O",
"O",
"O",
"B-T033",
"O",
"O",... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db... | [
"Efficacy",
"of",
"a",
"coaxial",
"system",
"with",
"a",
"compliant",
"balloon",
"catheter",
"for",
"navigation",
"of",
"the",
"Penumbra",
"reperfusion",
"catheter",
"in",
"tortuous",
"arteries",
":",
"technique",
"and",
"case",
"experience",
"OBJECTIVE",
"The",
... | [
[
0,
8
],
[
9,
11
],
[
12,
13
],
[
14,
21
],
[
22,
28
],
[
29,
33
],
[
34,
35
],
[
36,
45
],
[
46,
53
],
[
54,
62
],
[
63,
66
],
[
67,
77
],
[
78,
80
],
[
8... | Efficacy of a coaxial system with a compliant balloon catheter for navigation of the Penumbra reperfusion catheter in tortuous arteries: technique and case experience OBJECTIVE The authors describe a method by which they easily and atraumatically navigate a large-bore reperfusion catheter of the Penumbra system to an embolus by using a coaxial system with a compliant balloon catheter in patients with tortuous arteries. METHODS A retrospective review of the prospective endovascular database was performed to identify cases in which a coaxial system with a compliant balloon catheter (Scepter C, MicroVention / Terumo; or TransForm C, Stryker Neurovascular) and a large-bore reperfusion catheter of the Penumbra system (Penumbra, Inc.) was used. The authors achieved a stable guiding sheath position and delivered the coaxial system with a compliant balloon catheter and a large-bore reperfusion catheter. Then, the balloon was inflated somewhat when the distal tip of the balloon was slightly advanced from the tip of the reperfusion catheter, and together the coaxial system was advanced to an embolus over a 0.014-in guidewire, even around the corner. When the distal tip of the balloon catheter reached the embolus, the authors deflated the balloon and navigated the large-bore reperfusion catheter to the embolus. Finally, the aspiration of the embolus with the Penumbra MAX pump was begun. RESULTS Between May 2014 and September 2015, the authors used this technique in 17 cases: 16 cases of middle cerebral artery occlusion (including 5 cases of internal carotid artery occlusion) and 1 case of basilar artery occlusion (age range 36-88 years, mean age 74.7 years, 13 men). For the reperfusion catheter of the Penumbra system, the 5MAX ACE was used in 15 cases, and the 5MAX was used in 2 cases. As a compliant balloon catheter, the Scepter C was used in 16 cases, and the TransForm C was used in 1 case. The technique was successful in 16 cases (94.1%). No parent artery dissections were noted in any cases. Catheter -induced vasospasm was noted in 1 case, but the vasospasm was transient. CONCLUSIONS A coaxial system with a compliant balloon catheter can help safely and easily to navigate the large-bore reperfusion catheter of the Penumbra system to an embolus in patients with tortuous arteries. |
[
"B-T082",
"O",
"B-T017",
"O",
"B-T058",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"I-T204",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": "C0205054",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0022646",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0220825",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Hepatic",
"and",
"renal",
"toxicological",
"evaluations",
"of",
"an",
"industrial",
"ovotoxic",
"chemical",
",",
"4",
"-",
"vinylcyclohexene",
"diepoxide",
",",
"in",
"both",
"sexes",
"of",
"Wistar",
"rats",
"4",
"-",
"Vinylcyclohexene",
"diepoxide",
"(",
"VCD"... | [
[
0,
7
],
[
8,
11
],
[
12,
17
],
[
18,
31
],
[
32,
43
],
[
44,
46
],
[
47,
49
],
[
50,
60
],
[
61,
69
],
[
70,
78
],
[
78,
79
],
[
80,
81
],
[
81,
82
],
[
8... | Hepatic and renal toxicological evaluations of an industrial ovotoxic chemical, 4-vinylcyclohexene diepoxide, in both sexes of Wistar rats 4-Vinylcyclohexene diepoxide (VCD) is an industrial occupational health hazard chemical because it induces ovotoxicity in rodents. The current study investigated the impacts of VCD on selected hepatic and renal markers of oxidative stress and inflammation in both sexes of Wistar rats. Thus, male and female rats were randomly distributed into four groups of ten rats per group, and dosed orally with VCD for 28 days. The control male and female groups of rats received corn oil only, while each of the three remaining groups of both sexes of rats received VCD (100, 250 and 500 mg/kg BW) respectively. Thereafter, biomarkers of hepatic and renal oxidative damage, inflammation and immunohistochemical expressions of iNOS, COX-2, caspase-9 and caspase-3 were evaluated. The results revealed that VCD increased markers of liver and kidney functions, oxidative damage and inflammation, and disrupted the antioxidant homeostasis of the rats (p<0.05). Lastly, VCD enhanced the immunohistochemical expressions of iNOS, COX-2, caspase-9 and caspase-3 in the liver of the rats. Thus, our data imply that VCD induced toxicity in the liver and kidney of rats via the combined impacts of oxidative damage and inflammation. |
[
"B-T103",
"I-T103",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"B-T103",
"I-T103",
"B-T103",
"I-T103",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"B-T103",
"O",
"B-T103",
... | [
{
"db_id": "C0376433",
"db_name": "UMLS"
},
{
"db_id": "C0376433",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0037813",
"db_name": "UMLS"
},
{
... | [
"Combinatorial",
"Library",
"Screening",
"Coupled",
"to",
"Mass",
"Spectrometry",
"to",
"Identify",
"Valuable",
"Cyclic",
"Peptides",
"Combinatorial",
"library",
"screening",
"coupled",
"to",
"mass",
"spectrometry",
"(",
"MS",
")",
"analysis",
"is",
"a",
"practical"... | [
[
0,
13
],
[
14,
21
],
[
22,
31
],
[
32,
39
],
[
40,
42
],
[
43,
47
],
[
48,
60
],
[
61,
63
],
[
64,
72
],
[
73,
81
],
[
82,
88
],
[
89,
97
],
[
98,
111
],
[
... | Combinatorial Library Screening Coupled to Mass Spectrometry to Identify Valuable Cyclic Peptides Combinatorial library screening coupled to mass spectrometry (MS) analysis is a practical approach to identify useful peptides. Cyclic peptides can have high biological activity, selectivity, and affinity for target proteins, and high stability against proteolytic degradation. Here we describe two strategies to prepare combinatorial libraries suitable for MS analysis to accelerate the discovery of cyclic peptide structures. Both approaches use ChemMatrix resin and the linker 4-hydroxymethylbenzoic acid. One strategy involves the synthesis of a one-bead-two-peptides library in which each bead contains both the cyclic peptide and its linear counterpart to facilitate MS analysis. The other protocol is based on the synthesis of a cyclic depsipeptide library in which a glycolamidic ester group is incorporated by adding glycolic acid. After library screening, the ring is opened and the peptide is released simultaneously for subsequent MS analysis. © 2016 by John Wiley & Sons, Inc. |
[
"B-T098",
"I-T098",
"I-T098",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T170",
"I-T170",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T097",
"I-T097",
"I-T097",
"O",
"O",
"O",
... | [
{
"db_id": "C0043210",
"db_name": "UMLS"
},
{
"db_id": "C0043210",
"db_name": "UMLS"
},
{
"db_id": "C0043210",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Women",
"'",
"s",
"Sexual",
"Issues",
"After",
"Myocardial",
"Infarction",
":",
"A",
"Literature",
"Review",
"Sexual",
"activity",
"after",
"myocardial",
"infarction",
"(",
"MI",
")",
"is",
"a",
"concern",
"for",
"patients",
"and",
"often",
"a",
"challenge",
... | [
[
0,
5
],
[
5,
6
],
[
6,
7
],
[
8,
14
],
[
15,
21
],
[
22,
27
],
[
28,
38
],
[
39,
49
],
[
49,
50
],
[
51,
52
],
[
53,
63
],
[
64,
70
],
[
71,
77
],
[
78,
... | Women's Sexual Issues After Myocardial Infarction: A Literature Review Sexual activity after myocardial infarction (MI) is a concern for patients and often a challenge for health care professionals to address. It is widely recognized that most patients, of both sexes, report sexual problems or concerns after MI. However, there are reported differences between men and women. Women with sexual concerns may seek less help from health care providers and are more inclined to conceal them because of cultural barriers. The aim of the current study is to present a comprehensive review of the literature describing women's sexual issues after MI. A systematic search of the relevant literature was performed within international databases, including PubMed / Medline, Scopus, ScienceDirect, and ProQuest, as well as Google Scholar using relevant keywords. Also, Persian electronic databases such as Magiran, Scientific Information Databases, and Iran Medex were searched from the inception to October 2014. Articles focusing on the sexual issues after MI only in women, as well as articles on both sexes where women's results could be separated, were included in this review. A total of 8 articles were included in the final dataset. The main themes of women's sexual concerns after MI were " loss or decrease of sexual activity ," " dissatisfaction of sexual relationship ," " doubt about resumption time of sexual activity ," " fear of reinfarction or sudden death during sexual activity after MI ," " knowledge deficit regarding sexual activity after MI ," and " poor performance of health care providers in sexual counseling ." The results of this review demonstrate that women's post- MI sexual activity is affected by many concerns. The concerns may be a knowledge deficit related to not receiving necessary consultation on this topic. Nurses, as first-line care givers, can provide appropriate consultation and education for patients post- MI. As a result, breaking taboo imposed by cultural barriers, personal assumptions, or lack of confidence on giving sexual consultation may ultimately help patients to improve their quality of life. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"B-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db... | [
"Effect",
"of",
"autohydrolysis",
"on",
"the",
"wettability",
",",
"absorbility",
"and",
"further",
"alkali",
"impregnation",
"of",
"poplar",
"wood",
"chips",
"Autohydrolysis",
"with",
"different",
"severity",
"factors",
"was",
"performed",
"on",
"poplar",
"wood",
... | [
[
0,
6
],
[
7,
9
],
[
10,
24
],
[
25,
27
],
[
28,
31
],
[
32,
43
],
[
43,
44
],
[
45,
56
],
[
57,
60
],
[
61,
68
],
[
69,
75
],
[
76,
88
],
[
89,
91
],
[
92... | Effect of autohydrolysis on the wettability, absorbility and further alkali impregnation of poplar wood chips Autohydrolysis with different severity factors was performed on poplar wood chips prior to pulping, and the wettability, absorbility and the following impregnation of NaOH solution for the poplar wood chips were then investigated. The results showed that after autohydrolysis pretreatment the porosity, shrinkage and fiber saturation point (FSP) of the poplar wood chips were increased, while the surface contact angle decreased as the severity factor was increased. The autohydrolyzed chips absorbed more NaOH in impregnation that resulted in a low NaOH concentration in the bulk impregnation liquor (i.e., the impregnation liquor outside wood chips), while the concentration in the entrapped liquor (i.e., the impregnation liquor inside wood chips) was increased. Autohydrolysis substantially improved the effectiveness of alkali impregnation. |
[
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"O",
"B-T017",
"I-T017",
"I-T017",
"O",
"B-T031",
"I-T031",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"O",... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C3888803",
"db_name": "UMLS"
},
{
"db_id": "C3888803",
"db_name": "UMLS"
},
{
"db_id": "C3888803",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Effect",
"of",
"Transcatheter",
"Arterial",
"Chemoembolization",
"Combined",
"with",
"Argon",
"-",
"Helium",
"Cryosurgery",
"System",
"on",
"the",
"Changes",
"of",
"NK",
"Cells",
"and",
"T",
"Cell",
"Subsets",
"in",
"Peripheral",
"Blood",
"of",
"Hepatocellular",
... | [
[
0,
6
],
[
7,
9
],
[
10,
23
],
[
24,
32
],
[
33,
50
],
[
51,
59
],
[
60,
64
],
[
65,
70
],
[
70,
71
],
[
71,
77
],
[
78,
89
],
[
90,
96
],
[
97,
99
],
[
10... | Effect of Transcatheter Arterial Chemoembolization Combined with Argon-Helium Cryosurgery System on the Changes of NK Cells and T Cell Subsets in Peripheral Blood of Hepatocellular Carcinoma Patients Hepatocellular carcinoma (HCC) is one of the most aggressive tumors in humans. T lymphocytes and natural killer (NK) cells are the body's first line of defense to prevent tumor cell growth. Previous studies have demonstrated that transcatheter arterial chemoembolization (TACE) combined with argon-helium cryosurgery system (AHCS) can effectively treat liver cancer. However, the mechanism of the treatment is unclear yet. In the current study, we investigated the effects of TACE combined with AHCS on the changes of T cell subsets and NK cells in peripheral blood of HCC. Our data show that alpha-fetoprotein (AFP) levels in peripheral blood were significantly up-regulated in HCC patients before treatment when compared with healthy people and reduced after TACE combined with AHCS treatment (P < 0.01). In addition, we found that CD4+ cells and NK cells decreased (P < 0.05) and CD8+ cells increased (P < 0.05) in HCC patients when compared with healthy people. After treatment, the CD4+ cells, CD4+ / CD8+ ratio, and NK cells were dramatically increased in HCC patients (P < 0.05). In contrast, CD8+ cells were significantly decreased (P < 0.05). TACE combined with AHCS treatment significantly prolonged 1- year survival rate of HCC patients and did not show significant side effects. Taken together, our data indicate that TACE combined with AHCS treatment improves patients ' immune system. It is a feasible and effective therapeutic method for HCC patients. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"B-T... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db... | [
"The",
"\"",
"tight",
"orbit",
"\"",
":",
"Incidence",
"and",
"management",
"of",
"the",
"orbital",
"compartment",
"syndrome",
"The",
"orbital",
"compartment",
"syndrome",
"(",
"OCS",
")",
"constitutes",
"a",
"severe",
"emergency",
",",
"requiring",
"immediate",... | [
[
0,
3
],
[
4,
5
],
[
5,
10
],
[
11,
16
],
[
16,
17
],
[
17,
18
],
[
19,
28
],
[
29,
32
],
[
33,
43
],
[
44,
46
],
[
47,
50
],
[
51,
58
],
[
59,
70
],
[
71,... | The "tight orbit": Incidence and management of the orbital compartment syndrome The orbital compartment syndrome (OCS) constitutes a severe emergency, requiring immediate clinical diagnosis and surgical decompression. The key symptom is progressive visual impairment caused by an increase in intraorbital pressure, impairing the perfusion of relevant neurovascular and neurosensory structures. Intraorbital bleeding due to trauma and surgical intervention is known to be the main etiological factor. A retrospective analysis of all patients affected by an OCS between January 1, 2012, and May 31, 2015, was performed. Patients' records were reviewed with regard to etiology, initial ophthalmologic status, fracture pattern, concomitant medication, surgical management, and postoperative outcome. The incidence of OCS was calculated based on the total number of craniomaxillofacial (CMF) emergencies. Within 3.5 years, a total of 18,093 CMF emergencies were registered. In 16 patients, an OCS was documented, corresponding to an incidence of 0.088%. The mean patient age was 67.31 ± 23.86 years, ranging from 22 to 102 years. The etiology varied, but trauma with subsequent intraorbital bleeding was the main cause. The use of anticoagulative medication was documented in 50% of the cases. In 14 patients, immediate surgical orbital decompression was performed: in 10 patients, vision could be preserved; in three patients, blindness resulted; and one patient was lost to follow-up. Two patients were managed without surgery. With regard to the total number of CMF emergencies, OCS is a rare condition. Early clinical diagnosis and surgical decompression are required to prevent permanent vision impairment. Anticoagulative medication must be considered as a predisposing factor for an orbital compartment syndrome in patients affected by periorbital trauma. |
[
"B-T103",
"O",
"O",
"B-T082",
"I-T082",
"O",
"O",
"O",
"O",
"B-T005",
"B-T017",
"I-T017",
"O",
"O",
"O",
"O",
"B-T204",
"B-T031",
"O",
"B-T204",
"O",
"O",
"B-T031",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"O",
"O",
"B... | [
{
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},
{
"db_id": null,
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{
"db_id": null,
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{
"db_id": "C0444498",
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{
"db_id": "C0444498",
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{
"db_id": null,
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{
... | [
"Ammonia",
"as",
"an",
"In",
"Situ",
"Sanitizer",
":",
"Influence",
"of",
"Virus",
"Genome",
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"(",
"HEAM",
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"the",
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... | [
[
0,
7
],
[
8,
10
],
[
11,
13
],
[
14,
16
],
[
17,
21
],
[
22,
31
],
[
31,
32
],
[
33,
42
],
[
43,
45
],
[
46,
51
],
[
52,
58
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[
59,
63
],
[
64,
66
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[
6... | Ammonia as an In Situ Sanitizer: Influence of Virus Genome Type on Inactivation Treatment of human excreta and animal manure (HEAM) is key in controlling the spread of persistent enteric pathogens, such as viruses. The extent of virus inactivation during HEAM storage and treatment appears to vary with virus genome type, although the reasons for this variability are not clear. Here, we investigated the inactivation of viruses of different genome types under conditions representative of HEAM storage or mesophilic digestion. The goals were to characterize the influence of HEAM solution conditions on inactivation and to determine the potential mechanisms involved. Specifically, eight viruses representing the four viral genome types (single-stranded RNA [ssRNA], double-stranded RNA [dsRNA], single-stranded DNA [ssDNA], and double-stranded DNA [dsDNA]) were exposed to synthetic solutions with well-controlled temperature (20 to 35°C), pH (8 to 9), and ammonia (NH3) concentrations (0 to 40 mmol liter(-1)). DNA and dsRNA viruses were considerably more resistant than ssRNA viruses, resulting in up to 1,000-fold-longer treatment times to reach a 4-log inactivation. The apparently slower inactivation of DNA viruses was rationalized by the higher stability of DNA than that of ssRNA in HEAM. Pushing the system toward harsher pH (>9) and temperature (>35°C) conditions, such as those encountered in thermophilic digestion and alkaline treatments, led to more consistent inactivation kinetics among ssRNA and other viruses. This suggests that the dependence of inactivation on genome type disappeared in favor of protein -mediated inactivation mechanisms common to all viruses. Finally, we recommend the use of MS2 as a conservative indicator to assess the inactivation of ssRNA viruses and the stable ΦX174 or dsDNA phages as indicators for persistent viruses. Viruses are among the most environmentally persistent pathogens. They can be present in high concentrations in human excreta and animal manure (HEAM). Therefore, appropriate treatment of HEAM is important prior to its reuse or discharge into the environment. Here, we investigated the factors that determine the persistence of viruses in HEAM, and we determined the main mechanisms that lead to their inactivation. Unlike other organisms, viruses can have four different genome types (double- or single-stranded RNA or DNA), and the viruses studied herein represent all four types. Genome type appeared to be the major determinant for persistence. Single-stranded RNA viruses are the most labile, because this genome type is susceptible to degradation in HEAM. In contrast, the other genome types are more stable; therefore, inactivation is slower and mainly driven by the degradation of viral proteins. Overall, this study allows us to better understand the behavior of viruses in HEAM. |
[
"O",
"B-T058",
"O",
"O",
"B-T204",
"I-T204",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"B-T204",
"B-T204",
"O",
"O",
"O",
"B-T033",
"O",
"B-T062",
"I-T062",
"O",
"B-T038"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C2350499",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id": null,
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},
{
"db_id": "C0023276",
"db_name": "UMLS"
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{
"db_id": "C0023276",
"db_name": "UMLS"
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{
... | [
"An",
"electrochemical",
"genosensor",
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"Leishmania",
"major",
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"based",
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"electrocatalysis",
"of",
"cobalt",
"-",
"zinc",
"ferrite",
"quantum",
"dots",
"Identification",
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"Leishmania",
"pa... | [
[
0,
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[
3,
18
],
[
19,
29
],
[
30,
33
],
[
34,
44
],
[
45,
50
],
[
51,
60
],
[
61,
66
],
[
67,
69
],
[
70,
74
],
[
75,
81
],
[
82,
84
],
[
85,
99
],
[
1... | An electrochemical genosensor for Leishmania major detection based on dual effect of immobilization and electrocatalysis of cobalt-zinc ferrite quantum dots Identification of Leishmania parasites is important in diagnosis and clinical studies of leishmaniasis. Although epidemiological and clinical methods are available, they are not sufficient for identification of causative agents of leishmaniasis. In the present study, quantum dots of magnetic cobalt-zinc ferrite (Co0.5Zn0.5Fe2O4) were synthesized and characterized by physicochemical methods. The quantum dots were then employed as an electrode modifier to immobilize a 24-mer specific single stranded DNA probe, and fabrication of a label-free, PCR-free and signal-on electrochemical genosensor for the detection of Leishmania major. Hybridization of the complementary single stranded DNA sequence with the probe under the selected conditions was explored using methylene blue as a redox marker, utilizing the electrocatalytic effect of the quantum dots on the methylene blue electroreduction process. The genosensor could detect a synthetic single stranded DNA target in a range of 1.0×10(-11) to 1.0×10(-18)molL(-1) with a limit of detection of 2.0×10(-19)molL(-1), and genomic DNA in a range of 7.31×10(-14) to 7.31×10(-6)ngμL(-1) with a limit of detection of 1.80×10(-14)ngμL(-1) with a high selectivity and sensitivity. |
[
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0598695",
"db_name": "UMLS"
},
{
"db_id": "C0598695",
"db_name": "UMLS"
},
{
"db_id": "C0598695",
"db_name": "UMLS"
},
{
"db_id": "C0598695",
"db_name": "UMLS"
},
{
"db_id": "C0598695",
"db_name": "U... | [
"The",
"N",
"-",
"Methyl",
"d",
"-",
"Aspartate",
"Glutamate",
"Receptor",
"Antagonist",
"Ketamine",
"Disrupts",
"the",
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"Corticothalamic",
"Pathway",
"The",
"non",
"-",
"competitive",
"N",
"-",
"methyl",
"d",
"-",
"aspartate... | [
[
0,
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[
4,
5
],
[
5,
6
],
[
6,
12
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[
13,
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[
14,
15
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[
15,
24
],
[
25,
34
],
[
35,
43
],
[
44,
54
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[
55,
63
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[
64,
72
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[
73,
76
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[
77,
... | The N-Methyl d-Aspartate Glutamate Receptor Antagonist Ketamine Disrupts the Functional State of the Corticothalamic Pathway The non-competitive N-methyl d-aspartate glutamate receptor (NMDAR) antagonist ketamine elicits a brain state resembling high-risk states for developing psychosis and early stages of schizophrenia characterized by sensory and cognitive deficits and aberrant ongoing gamma oscillations (30-80 Hz)in cortical and subcortical structures, including the thalamus. The underlying mechanisms are unknown. The goal of the present study was to determine whether a ketamine - induced psychotic - relevant state disturbs the functional state of the corticothalamic (CT) pathway. Multisite field recordings were performed in the somatosensory CT system of the sedated rat. Baseline activity was challenged by activation of vibrissa - related prethalamic inputs. The sensory - evoked thalamic response was characterized by a short - latency (∼4 ms) prethalamic -mediated negative sharp potential and a longer latency (∼10 ms) CT -mediated negative potential. Following a single subcutaneous injection of ketamine (2.5 mg/kg), spontaneously occurring and sensory - evoked thalamic gamma oscillations increased and decreased in power, respectively. The power of the sensory -related gamma oscillations was positively correlated with both the amplitude and the area under the curve of the corresponding CT potential but not with the prethalamic potential. The present results show that the layer VI CT pathway significantly contributes in thalamic gamma oscillations, and they support the hypothesis that reduced NMDAR activation disturbs the functional state of CT and corticocortical networks. |
[
"O",
"B-T058",
"I-T058",
"O",
"O",
"B-T103",
"O",
"O",
"B-T017",
"O",
"B-T017",
"I-T017",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0021083",
"db_name": "UMLS"
},
{
"db_id": "C0021083",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0022144",
"db_name": "UMLS"
},
{
... | [
"Novel",
"immunotherapeutic",
"strategies",
"to",
"target",
"alloantibody",
"-",
"producing",
"B",
"and",
"plasma",
"cells",
"in",
"transplantation",
"There",
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"an",
"unmet",
"need",
"for",
"immunotherapeutic",
"agents",
"that",
"target",
"humoral",
"alloimmuni... | [
[
0,
5
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[
6,
23
],
[
24,
34
],
[
35,
37
],
[
38,
44
],
[
45,
57
],
[
58,
59
],
[
59,
68
],
[
69,
70
],
[
71,
74
],
[
75,
81
],
[
82,
87
],
[
88,
90
],
[
9... | Novel immunotherapeutic strategies to target alloantibody -producing B and plasma cells in transplantation There is an unmet need for immunotherapeutic agents that target humoral alloimmunity in solid organ transplantation. This includes sensitized patients with preformed donor -specific human leucocyte antigen antibodies and patients who develop de-novo donor -specific antibodies, both of which are associated with acute and chronic antibody-mediated rejection and allograft loss. In this review, we discuss recent progress in the generation of B-cell and plasma cell -targeted therapeutics, with an emphasis on novel agents. To deplete or inhibit B cells, B-cell -specific mAbs have been developed, including CD20, CD22, CD19 and bi-specific antibodies that target two B-cell antigens. In addition, inhibition of B-cell - activating cytokines, such as B cell-activating factor, may also reduce allo-B-cell activation. Plasma cells remain a difficult therapeutic target, but inhibition of germinal centre responses via costimulatory blockade or IL21 neutralization, induction of plasma cell apoptosis using proteasome inhibitors or disruption of the plasma cell niche are potential avenues being explored. The ultimate aim of these animal and human studies is to develop agents that efficiently target humoral effectors, whilst sparing B and plasma cells with a regulatory capacity to promote long-term allograft survival, but we remain some distance away from this goal. |
[
"B-T033",
"I-T033",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"O",
"O... | [
{
"db_id": "C1148433",
"db_name": "UMLS"
},
{
"db_id": "C1148433",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Survival",
"status",
"and",
"functional",
"outcome",
"of",
"children",
"who",
"required",
"prolonged",
"intensive",
"care",
"after",
"cardiac",
"surgery",
"Children",
"who",
"require",
"prolonged",
"intensive",
"care",
"after",
"cardiac",
"surgery",
"are",
"at",
... | [
[
0,
8
],
[
9,
15
],
[
16,
19
],
[
20,
30
],
[
31,
38
],
[
39,
41
],
[
42,
50
],
[
51,
54
],
[
55,
63
],
[
64,
73
],
[
74,
83
],
[
84,
88
],
[
89,
94
],
[
9... | Survival status and functional outcome of children who required prolonged intensive care after cardiac surgery Children who require prolonged intensive care after cardiac surgery are at risk of high mortality. The long-term survival and functional outcome of these children have not been studied in detail. Children who stayed in intensive care for >28 days after cardiac surgery from 1997 to 2012 were studied in a single institution. A total of 116 patients were identified; 107 (92%) were <1 year of age and 63 (54%) had univentricular physiology. The incidence of children requiring prolonged intensive care increased from 1.01/100 undergoing cardiac surgery in 1997 to 2000 to 2.66/100 in 2009 to 2012 (P trend = .002). This increase coincided with an increase in the number of children with hypoplastic left heart syndrome having prolonged intensive care during the same period (0.13/100 in 1997-2000 to 1.0/100 in 2009-2012; P trend = .001). Survival to pediatric intensive care unit (PICU) discharge was 74% (95% confidence interval [CI], 65-82) and 51% (95% CI, 41-59) at 3 years. Factors associated with mortality were univentricular repair (hazard ratio [HR], 2.12; 95% CI, 1.21-3.70; P = .008) and acute renal failure (HR, 3.01; 95% CI, 1.77-5.12; P < .001), but era did not influence mortality (1997-2005 vs 2006-2012; log-rank P = .66). Among PICU survivors, 3- year survival in those who did not need early reoperation was 81% (95% CI, 66-90), compared with 58% (95% CI, 42-71) in those who required early reoperation (log-rank P = .01). Among survivors, 36% had either moderate or severe disability and 13% had poor quality of life. The incidence of children requiring prolonged intensive care after cardiac surgery has increase d in our institution. Our data suggest that the long-term outcome for most of these children is poor, especially after univentricular repair. |
[
"O",
"B-T038",
"O",
"B-T017",
"B-T038",
"O",
"O",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"B-T038",
"O",
"O",
"B-T082",
"O",
"O",
"B-T098",
"I-T098",
"O",
"O",
"O",... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C2911691",
"db_name": "UMLS"
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{
"db_id": null,
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{
"db_id": "C0016504",
"db_name": "UMLS"
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{
"db_id": "C0242414",
"db_name": "UMLS"
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{
"db_id": null,
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{
... | [
"Haptic",
"feedback",
"helps",
"bipedal",
"coordination",
"The",
"present",
"study",
"investigated",
"whether",
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"-",
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"cyclical",
"feet",
"movem... | [
[
0,
6
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[
7,
15
],
[
16,
21
],
[
22,
29
],
[
30,
42
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[
43,
46
],
[
47,
54
],
[
55,
60
],
[
61,
73
],
[
74,
81
],
[
82,
89
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[
90,
96
],
[
97,
99
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[
1... | Haptic feedback helps bipedal coordination The present study investigated whether special haptic or visual feedback would facilitate the coordination of in-phase, cyclical feet movements of different amplitudes. Seventeen healthy participants sat with their feet on sliding panels that were moved externally over the same or different amplitudes. The participants were asked to generate simultaneous knee flexion-extension movements, or to let their feet be dragged, resulting in reference foot displacements of 150 mm and experimental foot displacements of 150, 120, or 90 mm. Four types of feedback were given: (1) special haptic feedback, involving actively following the motions of the sliders manipulated by two confederates, (2) haptic feedback resulting from passive motion, (3) veridical visual feedback, and (4) enhanced visual feedback. Both with respect to amplitude assimilation effects, correlations and standard deviation of relative phase, the results showed that enhanced visual feedback did not facilitate bipedal independence, but haptic feedback with active movement did. Implications of the findings for movement rehabilitation contexts are discussed. |
[
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"B-T103",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"O",
"O",... | [
{
"db_id": null,
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{
"db_id": null,
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{
"db_id": null,
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{
"db_id": null,
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},
{
"db_id": "C0029432",
"db_name": "UMLS"
},
{
"db_id": "C0029432",
"db_name": "UMLS"
},
{
"db_id... | [
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"vitro",
"bone",
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"The",
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"dianthin",
"G",
"promotes",
"osteoblast",
"(",
"bone",
"-",
"forming",
"cell",
"... | [
[
0,
9
],
[
10,
13
],
[
14,
16
],
[
17,
22
],
[
23,
27
],
[
28,
32
],
[
33,
41
],
[
42,
44
],
[
45,
54
],
[
55,
57
],
[
58,
61
],
[
62,
78
],
[
79,
87
],
[
... | Synthesis and in vitro bone cell activity of analogues of the cyclohexapeptide dianthin G The cyclohexapeptide natural product dianthin G promotes osteoblast (bone-forming cell) proliferation in vitro at nanomolar concentrations, and is therefore considered a promising candidate for the treatment of osteoporosis. An N(α)-methyl amide bond scan of dianthin G was performed to probe the effect of modifying amide bonds on osteoblast proliferation. In addition, to provide greater structural diversity, a series of dicarba dianthin G analogues was synthesised using ring closing metathesis. Dianthin G and one novel dicarba analogue increased the number of human osteoblasts and importantly they did not increase osteoclast (bone-resorbing cell) differentiation in bone marrow cells. |
[
"O",
"O",
"B-T038",
"I-T038",
"B-T168",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T168",
"I-T168",
"I-T168",
"O",
"O",
"O",
"O",
"B-T062",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"B-T082",
"O",
"O",
"B... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C3178952",
"db_name": "UMLS"
},
{
"db_id": "C3178952",
"db_name": "UMLS"
},
{
"db_id": "C0012155",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Effects",
"of",
"grazing",
"cow",
"diet",
"on",
"volatile",
"compounds",
"as",
"well",
"as",
"physicochemical",
"and",
"sensory",
"characteristics",
"of",
"12",
"-",
"month",
"-",
"ripened",
"Montasio",
"cheese",
"The",
"aim",
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"this",
"study",
"was",
... | [
[
0,
7
],
[
8,
10
],
[
11,
18
],
[
19,
22
],
[
23,
27
],
[
28,
30
],
[
31,
39
],
[
40,
49
],
[
50,
52
],
[
53,
57
],
[
58,
60
],
[
61,
76
],
[
77,
80
],
[
8... | Effects of grazing cow diet on volatile compounds as well as physicochemical and sensory characteristics of 12- month - ripened Montasio cheese The aim of this study was to evaluate the effects of pasture type and cow feeding supplementation level on a 12- mo - ripened Montasio protected designation of origin (PDO) cheese, which is one of the most important PDO cheeses produced in northeast Italy. Cheeses were characterized for volatile compounds, color, mechanical variables, and sensory descriptors. Pasture type significantly affected most of the instrumental variables considered and, as a consequence, sensory properties were affected as well. Cheeses from the pasture characterized by a nutrient-rich vegetation type were higher in protein and lower in fat content. Furthermore, such cheeses, evaluated by a sensory panel, were more intense in color with a more pungent and less cow-like odor, in agreement with what found through instrumental analyses. Supplementation level resulted in less pronounced effects, limited to volatile compounds and texture properties, which were not detected by sensory analysis. The characterization of the 12- mo ripened Montasio cheese reported here is an important step for the valorization of this PDO product. |
[
"O",
"O",
"O",
"O",
"B-T103",
"B-T103",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T007",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0025552",
"db_name": "UMLS"
},
{
"db_id": "C0022023",
"db_name": "UMLS"
},
{
"db_id... | [
"The",
"biological",
"effect",
"of",
"metal",
"ions",
"on",
"the",
"granulation",
"of",
"aerobic",
"granular",
"activated",
"sludge",
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"a",
"special",
"biofilm",
"structure",
",",
"microbial",
"attachment",
"is",
"believed",
"to",
"play",
"an",
"important",... | [
[
0,
3
],
[
4,
14
],
[
15,
21
],
[
22,
24
],
[
25,
30
],
[
31,
35
],
[
36,
38
],
[
39,
42
],
[
43,
54
],
[
55,
57
],
[
58,
65
],
[
66,
74
],
[
75,
84
],
[
8... | The biological effect of metal ions on the granulation of aerobic granular activated sludge As a special biofilm structure, microbial attachment is believed to play an important role in the granulation of aerobic granular activated sludge (AGAS). This experiment was to investigate the biological effect of Ca(2+), Mg(2+), Cu(2+), Fe(2+), Zn(2+), and K(+) which are the most common ions present in biological wastewater treatment systems, on the microbial attachment of AGAS and flocculent activated sludge (FAS), from which AGAS is always derived, in order to provide a new strategy for the rapid cultivation and stability control of AGAS. The result showed that attachment biomass of AGAS was about 300% higher than that of FAS without the addition of metal ions. Different metal ions had different effects on the process of microbial attachment. FAS and AGAS reacted differently to the metal ions as well, and in fact, AGAS was more sensitive to the metal ions. Specifically, Ca(2+), Mg(2+), and K(+) could increase the microbial attachment ability of both AGAS and FAS under appropriate concentrations, Cu(2+), Fe(2+), and Zn(2+) were also beneficial to the microbial attachment of FAS at low concentrations, but Cu(2+), Fe(2+), and Zn(2+) greatly inhibited the attachment process of AGAS even at extremely low concentrations. In addition, the acylated homoserine lactone (AHL)-based quorum sensing system, the content of extracellular polymeric substances and the relative hydrophobicity of the sludges were greatly influenced by metal ions. As all these parameters had close relationships with the microbial attachment process, the microbial attachment may be affected by changes of these parameters. |
[
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T1... | [
{
"db_id": "C0303636",
"db_name": "UMLS"
},
{
"db_id": "C0303636",
"db_name": "UMLS"
},
{
"db_id": "C0303636",
"db_name": "UMLS"
},
{
"db_id": "C0303636",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
}... | [
"Rh",
"(",
"III",
")",
"-",
"Catalyzed",
"Oxidative",
"Annulation",
"Leading",
"to",
"Substituted",
"Indolizines",
"by",
"Cleavage",
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"2",
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")",
"-",
"H",
"/",
"C",
"(",
"sp",
"(",
"3",
")",
")",
"-",
"H",
"Bonds",
"... | [
[
0,
2
],
[
2,
3
],
[
3,
6
],
[
6,
7
],
[
8,
9
],
[
10,
19
],
[
20,
29
],
[
30,
40
],
[
41,
48
],
[
49,
51
],
[
52,
63
],
[
64,
75
],
[
76,
78
],
[
79,
... | Rh(III) - Catalyzed Oxidative Annulation Leading to Substituted Indolizines by Cleavage of C(sp(2))-H/C(sp(3))-H Bonds Rhodium(III) - catalyzed oxidative annulation reactions of pyridinium trifluoromethanesulfonate salts with alkynes leading to substituted indolizines by cleavage of C(sp(2))-H/C(sp(3))-H bonds are developed. The starting materials are readily available, and the reactions have a broad substrate scope. This reaction overcomes some drawbacks of the previous indolizine synthetic methods and provides a new efficient route to indolizine derivatives. |
[
"B-T038",
"O",
"O",
"O",
"B-T038",
"I-T038",
"I-T038",
"B-T038",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"O",
"O",
"O",
"B-T082",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T03... | [
{
"db_id": "C1704275",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0024141",
"db_name": "UMLS"
},
{
"db_id": "C0024141",
"db_name": "UMLS"
},
{
... | [
"Pyomyositis",
"in",
"childhood",
"-",
"systemic",
"lupus",
"erythematosus",
"Pyomyositis",
"is",
"a",
"pyogenic",
"infection",
"of",
"skeletal",
"muscle",
"that",
"arises",
"from",
"hematogenous",
"spread",
"and",
"usually",
"presents",
"with",
"localized",
"absces... | [
[
0,
11
],
[
12,
14
],
[
15,
24
],
[
25,
26
],
[
27,
35
],
[
36,
41
],
[
42,
55
],
[
56,
67
],
[
68,
70
],
[
71,
72
],
[
73,
81
],
[
82,
91
],
[
92,
94
],
[
... | Pyomyositis in childhood - systemic lupus erythematosus Pyomyositis is a pyogenic infection of skeletal muscle that arises from hematogenous spread and usually presents with localized abscess. This muscle infection has been rarely reported in adult-onset systemic lupus erythematous and, to the best of our knowledge, has not been diagnosed in pediatric lupus population. Among our childhood-onset systemic lupus erythematous population, including 289 patients, one presented pyomyositis. This patient was diagnosed with childhood-onset systemic lupus erythematous at the age of 10 years-old. After six years, while being treated with prednisone, azathioprine and hydroxychloroquine, she was hospitalized due to a 30-day history of insidious pain in the left thigh and no apparent trauma or fever were reported. Her physical examination showed muscle tenderness and woody induration. Laboratory tests revealed anemia, increased acute phase reactants and normal muscle enzymes. Computer tomography of the left thigh showed collection on the middle third of the vastus intermedius, suggesting purulent stage of pyomyositis. Treatment with broad-spectrum antibiotic was initiated, leading to a complete clinical resolution. In conclusion, we described the first case of pyomyositis during childhood in pediatric lupus population. This report reinforces that the presence of localized muscle pain in immunocompromised patients, even without elevation of muscle enzymes, should raise the suspicion of pyomyositis. A prompt antibiotic therapy is strongly recommended. |
[
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"B-T033",
"I-T033",
"O",
"B-T033",
"B-T098",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"I-T033",
"O",
"B-T033",
"B-T098",
"O",
"O",
"B-T033",
"O",... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1956055",
"db_name": "UMLS"
},
{
"db_id": "C1956055",
"db_name": "UMLS"
},
{
"db_id... | [
"Quantitative",
"fetal",
"fibronectin",
"and",
"cervical",
"length",
"to",
"predict",
"preterm",
"birth",
"in",
"asymptomatic",
"women",
"with",
"previous",
"cervical",
"surgery",
"Quantitative",
"fetal",
"fibronectin",
"testing",
"has",
"demonstrated",
"accuracy",
"f... | [
[
0,
12
],
[
13,
18
],
[
19,
30
],
[
31,
34
],
[
35,
43
],
[
44,
50
],
[
51,
53
],
[
54,
61
],
[
62,
69
],
[
70,
75
],
[
76,
78
],
[
79,
91
],
[
92,
97
],
[
... | Quantitative fetal fibronectin and cervical length to predict preterm birth in asymptomatic women with previous cervical surgery Quantitative fetal fibronectin testing has demonstrated accuracy for prediction of spontaneous preterm birth in asymptomatic women with a history of preterm birth. Predictive accuracy in women with previous cervical surgery (a potentially different risk mechanism) is not known. We sought to compare the predictive accuracy of cervicovaginal fluid quantitative fetal fibronectin and cervical length testing in asymptomatic women with previous cervical surgery to that in women with 1 previous preterm birth. We conducted a prospective blinded secondary analysis of a larger observational study of cervicovaginal fluid quantitative fetal fibronectin concentration in asymptomatic women measured with a Hologic 10Q system (Hologic, Marlborough, MA). Prediction of spontaneous preterm birth (<30, <34, and <37 weeks) with cervicovaginal fluid quantitative fetal fibronectin concentration in primiparous women who had undergone at least 1 invasive cervical procedure (n = 473) was compared with prediction in women who had previous spontaneous preterm birth, preterm prelabor rupture of membranes, or late miscarriage (n = 821). Relationship with cervical length was explored. The rate of spontaneous preterm birth <34 weeks in the cervical surgery group was 3% compared with 9% in previous spontaneous preterm birth group. Receiver operating characteristic curves comparing quantitative fetal fibronectin for prediction at all 3 gestational end points were comparable between the cervical surgery and previous spontaneous preterm birth groups (34 weeks: area under the curve, 0.78 [95% confidence interval 0.64-0.93] vs 0.71 [95% confidence interval 0.64-0.78]; P = .39). Prediction of spontaneous preterm birth using cervical length compared with quantitative fetal fibronectin for prediction of preterm birth <34 weeks of gestation offered similar prediction (area under the curve, 0.88 [95% confidence interval 0.79-0.96] vs 0.77 [95% confidence interval 0.62-0.92], P = .12 in the cervical surgery group; and 0.77 [95% confidence interval 0.70-0.84] vs 0.74 [95% confidence interval 0.67-0.81], P = .32 in the previous spontaneous preterm birth group). Prediction of spontaneous preterm birth using cervicovaginal fluid quantitative fetal fibronectin in asymptomatic women with cervical surgery is valid, and has comparative accuracy to that in women with a history of spontaneous preterm birth. |
[
"B-T103",
"O",
"O",
"B-T204",
"B-T031",
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"B-T201",
"I-T201",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T097",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"O... | [
{
"db_id": "C0751973",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0034721",
"db_name": "UMLS"
},
{
"db_id": "C0229671",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Proteome",
"changes",
"in",
"rat",
"serum",
"after",
"a",
"chronic",
"ingestion",
"of",
"enriched",
"uranium",
":",
"Toward",
"a",
"biological",
"signature",
"of",
"internal",
"contamination",
"and",
"radiological",
"effect",
"The",
"civilian",
"and",
"military",... | [
[
0,
8
],
[
9,
16
],
[
17,
19
],
[
20,
23
],
[
24,
29
],
[
30,
35
],
[
36,
37
],
[
38,
45
],
[
46,
55
],
[
56,
58
],
[
59,
67
],
[
68,
75
],
[
75,
76
],
[
7... | Proteome changes in rat serum after a chronic ingestion of enriched uranium: Toward a biological signature of internal contamination and radiological effect The civilian and military use of uranium results in an increased risk of human exposure. The toxicity of uranium results from both its chemical and radiological properties that vary with isotopic composition. Validated biomarkers of health effects associated with exposure to uranium are neither sensitive nor specific to uranium radiotoxicity and/or radiological effect. This study aimed at investigating if serum proteins could be useful as biomarkers of both uranium exposure and radiological effect. Male Sprague-Dawley rats were chronically exposed through drinking water to low levels (40mg/L, corresponding to 1mg of uranium per animal per day) of either 4% (235) U-enriched uranium (EU) or 12% EU during 6 weeks. A proteomics approach based on two-dimensional electrophoresis (2D-DIGE) and mass spectrometry (MS) was used to establish protein expression profiles that could be relevant for discriminating between groups, and to identify some differentially expressed proteins following uranium ingestion. It demonstrated that the expressions of 174 protein spots over 1045 quantified spots were altered after uranium exposure (p<0.05). Using both inferential and non-supervised multivariate statistics, we show sets of spots features that lead to a clear discrimination between controls and EU exposed groups on the one hand (21 spots), and between 4% EU and 12% EU on the other hand (7 spots), showing that investigation of the serum proteome may possibly be of relevance to address both uranium contamination and radiological effect. Finally, using bioinformatics tools, pathway analyses of differentially expressed MS - identified proteins find that acute phase, inflammatory and immune responses as well as oxidative stress are likely involved in the response to contamination, suggesting a physiological perturbation, but that does not necessarily lead to a toxic effect. |
[
"O",
"O",
"B-T038",
"O",
"B-T037",
"I-T037",
"O",
"B-T038",
"B-T201",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"B-T201",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"B-T038",
"O",
"O",
"B-T037",
"I-T037",
"O... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0015376",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0149531",
"db_name": "UMLS"
},
{
"db_id": "C0149531",
"db_name": "UMLS"
},
{
... | [
"Prediction",
"of",
"extravasation",
"in",
"pelvic",
"fracture",
"using",
"coagulation",
"biomarkers",
"To",
"evaluate",
"the",
"usefulness",
"of",
"coagulation",
"biomarkers",
",",
"which",
"are",
"easy",
"and",
"quick",
"to",
"analyze",
"in",
"emergency",
"setti... | [
[
0,
10
],
[
11,
13
],
[
14,
27
],
[
28,
30
],
[
31,
37
],
[
38,
46
],
[
47,
52
],
[
53,
64
],
[
65,
75
],
[
76,
78
],
[
79,
87
],
[
88,
91
],
[
92,
102
],
[
... | Prediction of extravasation in pelvic fracture using coagulation biomarkers To evaluate the usefulness of coagulation biomarkers, which are easy and quick to analyze in emergency settings, for prediction of arterial extravasation due to pelvic fracture. The medical records of pelvic fracture patients transferred to the emergency department of Gunma University Hospital between December 2009 and May 2015 were reviewed. Patients were divided into two groups, those with (Extra(+)) and without (Extra(-)) arterial extravasation on enhanced CT or angiography. Levels of fibrin degradation products (FDP), D-dimer, fibrinogen, the ratio of FDP to fibrinogen, the ratio of D-dimer to fibrinogen, systolic blood pressure, heart rate, the Glasgow Coma Scale, pH, base excess, hemoglobin and lactate levels, the pattern of pelvic injury, and injury severity score were measured at hospital admission, and compared between the two groups. Parameters with a significant difference between the two groups were used to construct receiver operating characteristic (ROC) curves. The study included 29 patients with pelvic fracture. FDP, D-dimer, the ratio of FDP to fibrinogen and the ratio of D-dimer to fibrinogen were the most useful parameters for predicting arterial extravasation due to pelvic fracture. FDP, D-dimer, the ratio of FDP to fibrinogen, the ratio of D-dimer to fibrinogen, and hemoglobin and lactate levels were significantly higher in the Extra(+) group than in the Extra(-) group (FDP, 354.8μg/mL [median] versus 96.6μg/mL; D-dimer, 122.3μg/mL versus 42.1μg/mL; the ratio of FDP to fibrinogen, 3.39 versus 0.42; the ratio of D-dimer to fibrinogen, 1.14 versus 0.18; hemoglobin, 10.5g/dL versus 13.5g/dL; lactate, 3.5mmol/L versus 1.7mmol/L). The area under the ROC curves for FDP, D-dimer, the ratio of FDP to fibrinogen, the ratio of D-dimer to fibrinogen, hemoglobin and lactate levels were 0.900, 0.882, 0.918, 0.900, 0.815 and 0.765, respectively. Coagulation biomarkers, and hemoglobin and lactate levels could be useful to predict the existence of arterial extravasation due to pelvic fracture. The ratio of FDP to fibrinogen and the ratio of D-dimer to fibrinogen were the most accurate markers. Coagulation biomarkers may enable more rapid and specific treatment for pelvic fracture. |
[
"O",
"O",
"O",
"O",
"B-T033",
"O",
"B-T098",
"O",
"B-T098",
"B-T098",
"B-T098",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T098",
"O",
"B-T098",
"O",
"B-T098",
"B-T098",
"B-T098",
"O",
"B-T062",
"I-T062",
"I-T062",
"I-T06... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C1306577",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C033... | [
"Social",
"security",
"status",
"and",
"mortality",
"in",
"Belgian",
"and",
"Spanish",
"male",
"workers",
"To",
"assess",
"differences",
"in",
"mortality",
"rates",
"between",
"social",
"security",
"statuses",
"in",
"two",
"independent",
"samples",
"of",
"Belgian"... | [
[
0,
6
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[
7,
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],
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16,
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],
[
23,
26
],
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27,
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37,
39
],
[
40,
47
],
[
48,
51
],
[
52,
59
],
[
60,
64
],
[
65,
72
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73,
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76,
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[
8... | Social security status and mortality in Belgian and Spanish male workers To assess differences in mortality rates between social security statuses in two independent samples of Belgian and Spanish male workers. Study of two retrospective cohorts (Belgium, n=23,607; Spain, n=44,385) of 50-60 year old male employees with 4 years of follow-up. Mortality rate ratios (MRR) were estimated using Poisson regression models. Mortality for subjects with permanent disability was higher than for the employed, for both Belgium [MRR =4.56 (95% CI: 2.88-7.21)] and Spain [MRR =7.15 (95% CI: 5.37-9.51)]. For the unemployed / early retirees, mortality was higher in Spain [MRR =1.64 (95% CI: 1.24-2.17)] than in Belgium [MRR =0.88 (95% CI: 0.46-1.71)]. MRR differences between Belgium and Spain for unemployed workers could be partly explained because of differences between the two social security systems. Future studies should further explore mortality differences between countries with different social security systems. |
[
"O",
"O",
"O",
"B-T170",
"I-T170",
"I-T170",
"I-T170",
"I-T170",
"I-T170",
"O",
"B-T058",
"I-T058",
"I-T058",
"B-T062",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"I-T103",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T092",
"I-T092",
"I... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C4284879",
"db_name": "UMLS"
},
{
"db_id": "C4284879",
"db_name": "UMLS"
},
{
"db_id": "C4284879",
"db_name": "UMLS"
},
{
... | [
"Evaluation",
"of",
"the",
"Prostate",
"Imaging",
"Reporting",
"and",
"Data",
"System",
"for",
"Magnetic",
"Resonance",
"Imaging",
"Diagnosis",
"of",
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"Cancer",
"in",
"Patients",
"with",
"Prostate",
"-",
"specific",
"Antigen",
"<",
"20",
"ng",
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... | [
[
0,
10
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[
11,
13
],
[
14,
17
],
[
18,
26
],
[
27,
34
],
[
35,
44
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[
45,
48
],
[
49,
53
],
[
54,
60
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[
61,
64
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[
65,
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[
74,
83
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[
84,
91
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... | Evaluation of the Prostate Imaging Reporting and Data System for Magnetic Resonance Imaging Diagnosis of Prostate Cancer in Patients with Prostate-specific Antigen <20 ng/ml The European Society of Urogenital Radiology has built the Prostate Imaging Reporting and Data System (PI-RADS) for standardizing the diagnosis of prostate cancer (PCa). This study evaluated the PI-RADS diagnosis method in patients with prostate-specific antigen (PSA) <20 ng/ml. A total of 133 patients with PSA <20 ng/ml were prospectively recruited. T2-weighted (T2WI) and diffusion-weighted (DWI) magnetic resonance images of the prostate were acquired before a 12-core transrectal prostate biopsy. Each patient's peripheral zone was divided into six regions on the images; each region corresponded to two of the 12 biopsy cores. T2WI, DWI, and T2WI + DWI scores were computed according to PI-RADS. The diagnostic accuracy of the PI-RADS score was evaluated using histopathology of prostate biopsies as the reference standard. PCa was histologically diagnosed in 169 (21.2%) regions. Increased PI-RADS score correlated positively with increased cancer detection rate. The cancer detection rate for scores 1 to 5 was 2.8%, 15.0%, 34.6%, 52.6%, and 88.9%, respectively, using T2WI and 12.0%, 20.2%, 48.0%, 85.7%, and 93.3%, respectively, using DWI. For T2WI + DWI, the cancer detection rate was 1.5% (score 2), 13.5% (scores 3-4), 41.3% (scores 5-6), 75.9% (scores 7-8), and 92.3% (scores 9-10). The area under the curve for cancer detection was 0.700 (T2WI), 0.735 (DWI) and 0.749 (T2WI + DWI). The sensitivity and specificity were 53.8% and 89.2%, respectively, when using scores 5-6 as the cutoff value for T2WI + DWI. The PI-RADS score correlates with the PCa detection rate in patients with PSA <20 ng/ml. The summed score of T2WI + DWI has the highest accuracy in detection of PCa. However, the sensitivity should be further improved. |
[
"O",
"O",
"O",
"O",
"B-T103",
"O",
"B-T098",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"B-T062",
"O",
"B-T062",
"O",
"B-T062",
"I-T062",
"I-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"O",
"B-T103",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
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},
{
"db_id": null,
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{
"db_id": "C2000088",
"db_name": "UMLS"
},
{
"db_id": null,
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},
{
"db_id": "C007... | [
"Efficacy",
"and",
"safety",
"of",
"asenapine",
"in",
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"patients",
"with",
"an",
"acute",
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"randomized",
",",
"double",
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"blind",
",",
"6",
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",",
"placebo",
"-",
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36,
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42,
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[
51,
55
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56,
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59,
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[
65,
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[
78,
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8... | Efficacy and safety of asenapine in Asian patients with an acute exacerbation of schizophrenia: a multicentre, randomized, double-blind, 6- week, placebo-controlled study Asenapine is a second generation anti-psychotic approved in the USA in 2009 for the treatment of schizophrenia, but its efficacy has not been proven in Asian patients. The objectives of this study are to evaluate the efficacy and tolerability of asenapine in Asian patients experiencing an acute exacerbation of schizophrenia. In this prospective, double-blind study, patients in Japan, Korea, and Taiwan were randomized (1:1:1) to asenapine 5 mg twice daily (bid), 10 mg bid or placebo for 6 weeks after a 3- to 7- day washout / screening period. The primary endpoint was the mean change in the positive and negative syndrome scale (PANSS) total score from baseline to day 42/ treatment end. Of the 532 participants randomized, 530 received treatment. The primary endpoint was significantly greater with asenapine 5 and 10 mg bid than with placebo (-12.24 and -14.17 vs. -0.95; p < 0.0001). The results of secondary endpoints including PANSS negative subscale scores and PANSS responders at the end of treatment supported the results of the primary endpoint. There were no significant differences in the incidence of treatment -emergent adverse events reported with asenapine 5 and 10 mg bid and placebo (84.6, 80.7, and 81.6 %). There was a mean (± standard deviation) change in weight of -1.76 ± 2.45 kg for placebo, +0.42 ± 2.65 kg for asenapine 5 mg bid, and +0.81 ± 2.89 kg for asenapine 10 mg bid group. Asenapine was effective and generally well tolerated when used for the treatment of acute exacerbations of schizophrenia in Asian patients. |
[
"O",
"O",
"O",
"O",
"O",
"B-T033",
"I-T033",
"O",
"B-T204",
"I-T204",
"I-T204",
"I-T204",
"I-T204",
"O",
"B-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"I-T204",
"I-T204",
"I-T204",
"I-T204",
"O",
"B-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0422881",
"db_name": "UMLS"
},
{
"db_id": "C042... | [
"Effect",
"of",
"target",
"animacy",
"on",
"hand",
"preference",
"in",
"Sichuan",
"snub",
"-",
"nosed",
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"eight",
"captive",
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"snub",
"-",
"nosed",
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"rox... | [
[
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[
33,
43
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[
44,
46
],
[
47,
54
],
[
55,
59
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[
59,
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[
60,
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[
66,
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74... | Effect of target animacy on hand preference in Sichuan snub-nosed monkeys (Rhinopithecus roxellana) Twenty-eight captive Sichuan snub-nosed monkeys (Rhinopithecus roxellana) were involved in the current study. Many individuals showed handedness, with a modest tendency toward left-hand use especially for animate targets, although no group-level handedness was found. There was no significant gender difference in the direction and strength of hand preference for both targets. Females showed a significantly higher overall rate of actions toward animate targets than inanimate targets for both hands, whereas males displayed almost the reversed pattern. There were no significant interactions between lateral hand use and target animacy for either males or females. Most individuals showed rightward or leftward laterality shift trends between inanimate and animate targets. These findings to some extent support the existence of a potential trend concerning a categorical neural distinction between targets demanding functional manipulation (inanimate objects) and those demanding social manipulation (animate objects), even though specialized hand preference based on target animacy has not been fully established in this arboreal Old World monkey species. |
[
"O",
"O",
"B-T038",
"I-T038",
"O",
"O",
"B-T103",
"I-T103",
"I-T103",
"O",
"O",
"B-T038",
"I-T038",
"B-T038",
"I-T038",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0393639",
"db_name": "UMLS"
},
{
"db_id": "C0393639",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id... | [
"Association",
"of",
"Autoimmune",
"Encephalitis",
"With",
"Combined",
"Immune",
"Checkpoint",
"Inhibitor",
"Treatment",
"for",
"Metastatic",
"Cancer",
"Paraneoplastic",
"encephalitides",
"usually",
"precede",
"a",
"diagnosis",
"of",
"cancer",
"and",
"are",
"often",
"... | [
[
0,
11
],
[
12,
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],
[
15,
25
],
[
26,
38
],
[
39,
43
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[
44,
52
],
[
53,
59
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[
60,
70
],
[
71,
80
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[
81,
90
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[
91,
94
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[
95,
105
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[
106,
112
],
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... | Association of Autoimmune Encephalitis With Combined Immune Checkpoint Inhibitor Treatment for Metastatic Cancer Paraneoplastic encephalitides usually precede a diagnosis of cancer and are often refractory to immunosuppressive therapy. Conversely, autoimmune encephalitides are reversible conditions that can occur in the presence or absence of cancer. To report the induction of autoimmune encephalitis in 2 patients after treatment of metastatic cancer with a combination of the immune checkpoint inhibitors nivolumab and ipilimumab. A retrospective case study was conducted of the clinical and management course of 2 patients with progressive, treatment - refractory metastatic cancer who were treated with a single dose each (concomitantly) of the immune checkpoint inhibitors nivolumab, 1 mg/kg, and ipilimumab, 3 mg/kg. Nivolumab and ipilimumab. The clinical response to immunosuppressive therapy in suspected autoimmune encephalitis in the setting of immune checkpoint inhibitor use. Autoantibody testing confirmed identification of anti-N-methyl-D-aspartate receptor antibodies in the cerebrospinal fluid of 1 patient. Withdrawal of immune checkpoint inhibitors and initiation of immunosuppressive therapy, consisting of intravenous methylprednisolone sodium succinate equivalent to 1000 mg of methylprednisolone for 5 days, 0.4 mg/kg/d of intravenous immunoglobulin for 5 days, and 2 doses of rituximab, 1000 mg, in 1 patient and oral prednisone, 60 mg/d, in the other patient, resulted in improved neurologic symptoms. Immune checkpoint inhibition may favor the development of immune responses against neuronal antigens, leading to autoimmune encephalitis. Early recognition and treatment of autoimmune encephalitis in patients receiving immune checkpoint blockade therapy will likely be essential for maximizing clinical recovery and minimizing the effect of drug-related toxic effects. The mechanisms by which immune checkpoint inhibition may contribute to autoimmune encephalitis require further study. |
[
"B-T103",
"O",
"B-T082",
"B-T038",
"O",
"O",
"B-T017",
"I-T017",
"O",
"O",
"O",
"B-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T017",
"I-T017",
"I-T017",
"I-T017",
"I-T017",
"O",
"B-T204",
"I-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204"... | [
{
"db_id": "C0021920",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0456389",
"db_name": "UMLS"
},
{
"db_id": "C0032529",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Intron",
"Derived",
"Size",
"Polymorphism",
"in",
"the",
"Mitochondrial",
"Genomes",
"of",
"Closely",
"Related",
"Chrysoporthe",
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",",
"the",
"complete",
"mitochondrial",
"(",
"mt",
")",
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"austroafr... | [
[
0,
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[
7,
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[
15,
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],
[
20,
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],
[
33,
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[
36,
39
],
[
40,
53
],
[
54,
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[
62,
64
],
[
65,
72
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[
73,
80
],
[
81,
93
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[
94,
101
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[
... | Intron Derived Size Polymorphism in the Mitochondrial Genomes of Closely Related Chrysoporthe Species In this study, the complete mitochondrial (mt) genomes of Chrysoporthe austroafricana (190,834 bp), C. cubensis (89,084 bp) and C. deuterocubensis (124,412 bp) were determined. Additionally, the mitochondrial genome of another member of the Cryphonectriaceae, namely Cryphonectria parasitica (158,902 bp), was retrieved and annotated for comparative purposes. These genomes showed high levels of synteny, especially in regions including genes involved in oxidative phosphorylation and electron transfer, unique open reading frames (uORFs), ribosomal RNAs (rRNAs) and transfer RNAs (tRNAs), as well as intron positions. Comparative analyses revealed signatures of duplication events, intron number and length variation, and varying intronic ORFs which highlighted the genetic diversity of mt genomes among the Cryphonectriaceae. These mt genomes showed remarkable size polymorphism. The size polymorphism in the mt genomes of these closely related Chrysoporthe species was attributed to the varying number and length of introns, coding sequences and to a lesser extent, intergenic sequences. Compared to publicly available fungal mt genomes, the C. austroafricana mt genome is the second largest in the Ascomycetes thus far. |
[
"O",
"B-T005",
"B-T005",
"O",
"B-T038",
"O",
"B-T017",
"I-T017",
"B-T017",
"B-T005",
"O",
"O",
"B-T005",
"O",
"B-T005",
"O",
"B-T005",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"B-T033",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0016215",
"db_name": "UMLS"
},
{
"db_id": "C0011315",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0020564",
"db_name": "UMLS"
},
{
"db_id": null,
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},
{
... | [
"The",
"flavivirus",
"dengue",
"induces",
"hypertrophy",
"of",
"white",
"matter",
"astrocytes",
"Flaviviruses",
",",
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",",
"pose",
"a",
"serious",
"global",
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... | [
[
0,
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[
4,
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[
15,
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],
[
22,
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],
[
30,
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42,
44
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[
45,
50
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[
51,
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[
58,
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[
69,
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[
81,
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[
83,
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[
93,
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9... | The flavivirus dengue induces hypertrophy of white matter astrocytes Flaviviruses, including Zika and dengue (DENV), pose a serious global threat to human health. Of the 50+ million humans infected with DENV annually, approximately 1-3 % progress to severe disease manifestations, dengue hemorrhagic fever (DHF) or dengue shock syndrome (DSS). Several factors are suspected to mediate the course of infection and pathogenesis of DENV infection. DHF and DSS are associated with vascular leakage and neurological sequelae. Our hypothesis was that altered astrocyte activation and morphology would alter the dynamics of the extracellular space and hence, neuronal and vascular function. We investigated the mechanisms of neuropathogenesis DENV infection in rhesus macaques. There were decreased numbers of GFAP immunopositive astrocytes per unit area, although those that remained had increased arbor length and complexity. This was combined with structural hypertrophy of white matter astrocytes in the absence of increased vascular leakage. Combined, these studies show how even low-grade infection with DENV induces measurable changes within the parenchyma of infected individuals. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"O",
"O",
"O",
"O",
... | [
{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
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{
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{
"db_id": null,
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},
{
"db_id": null,
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},
{
"db_id": null,
"db... | [
"A",
"DANGEROUS",
"MUDDYING",
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... | [
[
0,
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[
2,
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[
12,
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],
[
21,
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],
[
24,
27
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28,
34
],
[
34,
35
],
[
36,
39
],
[
40,
41
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[
42,
53
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[
54,
58
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[
59,
60
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[
61,
63
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[
6... | A DANGEROUS MUDDYING OF THE WATERS? THE ' SIGNIFICANT HARM ' OF RE B AND G (CHILDREN) (CARE PROCEEDINGS)[2015] EWFC 3 The academic debate rages on as to whether male circumcision really is in the best interests of the child or if it constitutes an abusive practice. This commentary discusses the recent case of Re B and G (children) (care proceedings) [2015] EWFC 3, delivered by the current President of the Family Division of the High court, Sir James Munby. Two key issues are raised by this judgment. First, that President Munby's obiter comments constitute an attack on the legally accepted act of male circumcision by suggesting a similar nature between the illegal act of female genital mutilation (FGM) and that of male circumcision as well as the suggestion that male circumcision can be classed as a significant harm. Second, that this case reflects the woefully unprepared condition of the UK medical profession in dealing with FGM. |
[
"B-T103",
"I-T103",
"B-T103",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"B-T038",
"B-T038",
"I-T038",
"O",
"B-T038",
"I-T038",
"O",
"O",
"O",
"O",
"O",
"B-T103",
"O",
"O",
"B-T103",
"O",
"O",
"O",
"B-T038",
"I-T038",
"O",
"B-T038",
"O",
"O",
"B-T038",
"O"... | [
{
"db_id": "C1608304",
"db_name": "UMLS"
},
{
"db_id": "C1608304",
"db_name": "UMLS"
},
{
"db_id": "C1957162",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
... | [
"Zinc",
"transporter",
"ZIP10",
"forms",
"a",
"heteromer",
"with",
"ZIP6",
"which",
"regulates",
"embryonic",
"development",
"and",
"cell",
"migration",
"There",
"is",
"growing",
"evidence",
"that",
"zinc",
"and",
"its",
"transporters",
"are",
"involved",
"in",
... | [
[
0,
4
],
[
5,
16
],
[
17,
22
],
[
23,
28
],
[
29,
30
],
[
31,
40
],
[
41,
45
],
[
46,
50
],
[
51,
56
],
[
57,
66
],
[
67,
76
],
[
77,
88
],
[
89,
92
],
[
9... | Zinc transporter ZIP10 forms a heteromer with ZIP6 which regulates embryonic development and cell migration There is growing evidence that zinc and its transporters are involved in cell migration during development and in cancer. In the present study, we show that zinc transporter ZIP10 (SLC39A10) stimulates cell motility and proliferation, both in mammalian cells and in the zebrafish embryo. This is associated with inactivation of GSK-3α and -3ß and downregulation of E-cadherin (CDH1). Morpholino -mediated knock-down of zip10 causes delayed epiboly and deformities of the head, eye, heart and tail. Furthermore, zip10 deficiency results in overexpression of cdh1, zip6 and stat3, the latter gene product driving transcription of both zip6 and zip10 The non-reduntant requirement of Zip6 and Zip10 for epithelial to mesenchymal transition (EMT) is consistent with our finding that they exist as a heteromer. We postulate that a subset of ZIPs carrying PrP-like ectodomains, including ZIP6 and ZIP10, are integral to cellular pathways and plasticity programs, such as EMT. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T168",
"B-T168",
"I-T168",
"O",
"B-T168",
"B-T168",
"B-T170",
"O",
"O",
"B-T033",
"B-T062",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db... | [
"Demographics",
",",
"Health",
",",
"and",
"Risk",
"Behaviors",
"of",
"Young",
"Adults",
"Who",
"Drink",
"Energy",
"Drinks",
"and",
"Coffee",
"Beverages",
"Objective",
":",
"The",
"present",
"study",
"investigates",
"risk",
"behaviors",
",",
"sleep",
"habits",
... | [
[
0,
12
],
[
12,
13
],
[
14,
20
],
[
20,
21
],
[
22,
25
],
[
26,
30
],
[
31,
40
],
[
41,
43
],
[
44,
49
],
[
50,
56
],
[
57,
60
],
[
61,
66
],
[
67,
73
],
[
... | Demographics, Health, and Risk Behaviors of Young Adults Who Drink Energy Drinks and Coffee Beverages Objective: The present study investigates risk behaviors, sleep habits, and mental health factors associated with caffeinated beverage use in young adults. Materials and Methods: Students from a midsize private university (n = 159) completed a 15- minute anonymous questionnaire, including questions on risk behaviors, sleep habits, alcohol, and caffeine consumption. We compared behaviors between the top ∼15% ("high end") of energy drink users (≥3/ month) and coffee users (≥16/ month) to those with less frequent or no caffeine consumption. Results: Caffeine consumption was frequent among young adults. In the last month, 36% of students had an energy drink, 69% had coffee or espresso, and 86% reported having any caffeine; however, the majority of students were unaware of the caffeine content in these beverages. High-end energy drink consumers reported more risk-taking behaviors (increased drug and alcohol use and less frequent seat belt use), sleep disturbances (later bedtimes, harder time falling asleep, and more all-nighters), and higher frequency of mental illness diagnoses than those who consumed fewer energy drinks. In contrast, the frequency of most risk behaviors, sleep disturbances, and mental illness diagnoses was not significantly different between the high-end and general population of coffee drinkers. Conclusion: Students with delayed sleep patterns, mental illness, and higher frequency of substance use and risk behaviors were more likely to be regular energy drink users but not regular coffee drinkers. It is unclear whether the psychoactive content in energy drinks results in different behavioral effects than just caffeine in coffee, and/or different personality / health populations are drawn to the two types of beverages. |
[
"B-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T082",
"I-T082",
"I-T082",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T204",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T... | [
{
"db_id": "C0031865",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,... | [
"Phytoplankton",
"production",
"and",
"taxon",
"-",
"specific",
"growth",
"rates",
"in",
"the",
"Costa",
"Rica",
"Dome",
"During",
"summer",
"2010",
",",
"we",
"investigated",
"phytoplankton",
"production",
"and",
"growth",
"rates",
"at",
"19",
"stations",
"in",... | [
[
0,
13
],
[
14,
24
],
[
25,
28
],
[
29,
34
],
[
35,
36
],
[
37,
45
],
[
46,
52
],
[
53,
58
],
[
59,
61
],
[
62,
65
],
[
66,
71
],
[
72,
76
],
[
77,
81
],
[
... | Phytoplankton production and taxon - specific growth rates in the Costa Rica Dome During summer 2010, we investigated phytoplankton production and growth rates at 19 stations in the eastern tropical Pacific, where winds and strong opposing currents generate the Costa Rica Dome (CRD), an open - ocean upwelling feature. Primary production ((14)C - incorporation) and group-specific growth and net growth rates (two-treatment seawater dilution method) were estimated from samples incubated in situ at eight depths. Our cruise coincided with a mild El Niño event, and only weak upwelling was observed in the CRD. Nevertheless, the highest phytoplankton abundances were found near the dome center. However, mixed-layer growth rates were lowest in the dome center (∼0.5-0.9 day(-1)), but higher on the edge of the dome (∼0.9-1.0 day(-1)) and in adjacent coastal waters (0.9-1.3 day(-1)). We found good agreement between independent methods to estimate growth rates. Mixed-layer growth rates of Prochlorococcus and Synechococcus were largely balanced by mortality, whereas eukaryotic phytoplankton showed positive net growth (∼0.5-0.6 day(-1)), that is, growth available to support larger (mesozooplankton) consumer biomass. These are the first group-specific phytoplankton rate estimates in this region, and they demonstrate that integrated primary production is high, exceeding 1 g C m(-2) day(-1) on average, even during a period of reduced upwelling. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"B-T074",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T058",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T074",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T058",
"I-T058",
"I-T058",
"I-T0... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0175649",
... | [
"Incidence",
"and",
"Impact",
"of",
"Patient",
"-",
"Prosthesis",
"Mismatch",
"in",
"Isolated",
"Aortic",
"Valve",
"Surgery",
"The",
"mains",
"topics",
"of",
"this",
"work",
"are",
"the",
"incidence",
"of",
"patient",
"-",
"prosthesis",
"mismatch",
"and",
"the... | [
[
0,
9
],
[
10,
13
],
[
14,
20
],
[
21,
23
],
[
24,
31
],
[
32,
33
],
[
34,
44
],
[
45,
53
],
[
54,
56
],
[
57,
65
],
[
66,
72
],
[
73,
78
],
[
79,
86
],
[
... | Incidence and Impact of Patient - Prosthesis Mismatch in Isolated Aortic Valve Surgery The mains topics of this work are the incidence of patient - prosthesis mismatch and the influence in the early results of isolated aortic valve surgery. In 193 patients isolated aortic valve surgery was performed. The study population was divided in three subgroups: 20 patients with severe, 131 patients with moderate and 42 patients without patient - prosthesis mismatch. The indexed effective orifice area was used to define the subgroups. Operative mortality and perioperative complications were considered the indicators of the early results of aortic valve surgery. The incidence of severe and moderate patient - prosthesis mismatch was respectively 10.3% and 67.8%. Hospital mortality and perioperative complications were: mortality 5% vs. 3.1% vs. 2.4% (p = 0.855), low cardiac output 5% vs. 6.9% vs. 4.8% (p = 0.861); pulmonary complications 5% vs. 3.1 vs. 0.0% (p = 0.430); exploration for bleeding 5% vs. 0.8% vs. 2.4% (p = 0.319); atrial fibrillation 30% vs. 19.8% vs. 11.9% (p = 0.225); wound infection 5% vs. 0.8% vs. 0.00% (p = 0.165), respectively for the group with severe, moderate and without patient - prosthesis mismatch. Patient - prosthesis mismatch is a common occurrence in aortic valve surgery. This phenomenon does not affect the early results of aortic valve surgery. |
[
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"B-T098",
"O",
"O",
"O",
"O",
"B-T201",
"I-T201",
"B-T038",
"O",
"O",
... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db... | [
"Nutrient",
"Intakes",
"in",
"Early",
"Life",
"and",
"Risk",
"of",
"Obesity",
"There",
"is",
"increasing",
"evidence",
"that",
"environmental",
"factors",
"in",
"early",
"life",
"predict",
"later",
"health",
".",
"The",
"early",
"adiposity",
"rebound",
"recorded... | [
[
0,
8
],
[
9,
16
],
[
17,
19
],
[
20,
25
],
[
26,
30
],
[
31,
34
],
[
35,
39
],
[
40,
42
],
[
43,
50
],
[
51,
56
],
[
57,
59
],
[
60,
70
],
[
71,
79
],
[
8... | Nutrient Intakes in Early Life and Risk of Obesity There is increasing evidence that environmental factors in early life predict later health. The early adiposity rebound recorded in most obese subjects suggests that factors promoting body fat development have operated in the first years of life. Birth weight, growth velocity and body mass index (BMI) trajectories seem to be highly sensitive to the environmental conditions present during pregnancy and in early life ("The first 1000 days "). Particularly, nutritional exposure can have a long-term effect on health in adulthood. The high protein-low fat diet often recorded in young children may have contributed to the rapid rise of childhood obesity prevalence during the last decades. Metabolic programming by early nutrition could explain the development of later obesity and adult diseases. |
[
"O",
"O",
"O",
"O",
"O",
"B-T103",
"B-T038",
"O",
"O",
"B-T017",
"I-T017",
"O",
"B-T058",
"O",
"O",
"B-T103",
"I-T103",
"O",
"B-T103",
"O",
"B-T103",
"I-T103",
"O",
"B-T204",
"O",
"O",
"O",
"O",
"O",
"B-T038",
"O",
"O",
"B-T017",
"I-T017",
"O",
"... | [
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0009325",
"db_name": "UMLS"
},
{
"db_id": "C117... | [
"Characteristics",
"of",
"the",
"fibroplasia",
"and",
"collagen",
"expression",
"in",
"the",
"abdominal",
"wall",
"after",
"implant",
"of",
"the",
"polypropylene",
"mesh",
"and",
"polypropylene",
"/",
"polyglecaprone",
"mesh",
"in",
"rats",
"To",
"compare",
"fibro... | [
[
0,
15
],
[
16,
18
],
[
19,
22
],
[
23,
34
],
[
35,
38
],
[
39,
47
],
[
48,
58
],
[
59,
61
],
[
62,
65
],
[
66,
75
],
[
76,
80
],
[
81,
86
],
[
87,
94
],
[
... | Characteristics of the fibroplasia and collagen expression in the abdominal wall after implant of the polypropylene mesh and polypropylene / polyglecaprone mesh in rats To compare fibroplasia and the resistance of the abdominal wall when polypropylene meshes and polypropylene / poliglecaprone are used. Seventy-seven male Wistar rats were divided into three groups: Control Group (for resistance); Group E (polypropylene mesh); and Group U (polypropylene / poliglecaprone mesh). The animals in Groups E and U had a standard muscular and aponeurotic defect, with integral peritoneum, and correction with the mesh. Measurements were taken 4, 7, 14, 28 and 56 days after surgery. The resistance, and collagen density were studied. Resistance on the 56th day was similar in both meshes. The gain in resistance described an ascending curve for the polypropylene mesh and was irregular in the case of the polypropylene / poliglecaprone. Fibroplasia showed a gain in type I and type III collagen in both groups (p<0.001). Collagen III stabilized in the 14th day and collagen I continued to ascend. The gain in resistance of the polypropylene mesh is regular and ascending, whereas the polypropylene / poliglecaprone is not regular. The final resistance of both meshes is similar; the collagen density increases over time, and show the same inflammatory potential. |
[
"B-T058",
"I-T058",
"O",
"O",
"B-T074",
"B-T074",
"I-T074",
"I-T074",
"I-T074",
"O",
"B-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"I-T038",
"O",
"O",
"B-T082",
"O",
"O",
"B-T082",
"O",
"B-T082",
"O",
"O",
"B-T074",
"B-T074",
"I-T074",
"I-T07... | [
{
"db_id": "C4084924",
"db_name": "UMLS"
},
{
"db_id": "C4084924",
"db_name": "UMLS"
},
{
"db_id": null,
"db_name": null
},
{
"db_id": null,
"db_name": null
},
{
"db_id": "C0183001",
"db_name": "UMLS"
},
{
"db_id": "C0183001",
"db_name": "UMLS"
}... | [
"Clinical",
"evaluation",
"of",
"the",
"AutoPulse",
"automated",
"chest",
"compression",
"device",
"for",
"out",
"-",
"of",
"-",
"hospital",
"cardiac",
"arrest",
"in",
"the",
"northern",
"district",
"of",
"Shanghai",
",",
"China",
"Whether",
"the",
"AutoPulse",
... | [
[
0,
8
],
[
9,
19
],
[
20,
22
],
[
23,
26
],
[
27,
36
],
[
37,
46
],
[
47,
52
],
[
53,
64
],
[
65,
71
],
[
72,
75
],
[
76,
79
],
[
79,
80
],
[
80,
82
],
[
8... | Clinical evaluation of the AutoPulse automated chest compression device for out-of-hospital cardiac arrest in the northern district of Shanghai, China Whether the AutoPulse automated chest compression device is worthy of clinical use for out-of-hospital cardiac arrest (OHCA) remains controversial. A prospective controlled study was conducted to evaluate the effect of AutoPulse versus manual chest compression for cardiopulmonary resuscitation (CPR) of OHCA patients in the northern district of Shanghai, China. A total of 133 patients with OHCA who were treated at the Emergency Medical Center of the Tenth People's Hospital Affiliated with Tongji University between March 2011 and March 2012 were included. The patients were randomly assigned to the Manual CPR (n = 64) and AutoPulse CPR groups (n = 69) in accordance with the approach of chest compression received. The primary outcome measure was return of spontaneous circulation (ROSC), and the secondary outcome measures included 24-h survival rate, hospital discharge rate, and neurological prognosis at hospital discharge. The ROSC rate of patients with OHCA was significantly higher in the AutoPulse CPR group than in the Manual CPR group (44.9% vs. 23.4%; p = 0.009). The 24-h survival rate of OHCA patients was significantly higher in the AutoPulse CPR group than in the Manual CPR group (39.1% vs. 21.9%; p = 0.03). The hospital discharge rate of the patients with OHCA was significantly higher in the AutoPulse CPR group than in the Manual CPR group (18.8% vs. 6.3%; p = 0.03). The proportion of patients with OHCA and a cerebral performance category score of 1 or 2 points at hospital discharge was higher in the AutoPulse CPR group than in the Manual CPR group, but the difference was not statistically significant (16.2% vs. 13.4%, p = 1.00). Use of the AutoPulse increases CPR success and survival rates in patients with OHCA, but its ability to improve cerebral performance requires further evaluation. |
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