| --- |
| license: other |
| task_categories: |
| - tabular-classification |
| language: |
| - en |
| pretty_name: cytolexmuta ProteinGym DMS substitutions zero-shot scores |
| --- |
| |
| # cytolexmuta |
|
|
| `cytolexmuta` is a zero-shot map-fusion method for ProteinGym DMS substitutions. |
|
|
| It treats each component model as a complementary protein energy map: sequence-language plausibility, ProSST structure-aware likelihood, evolutionary coupling, and inverse-folding structural compatibility. These maps are projected into a shared assay-local coordinate system, and the released score follows a fixed convex path through that aligned map family. |
|
|
| The exact deterministic scoring rule is implemented in code. Normalization is computed independently within each DMS assay from prediction values only. The score files do not contain `DMS_score`, `DMS_score_bin`, labels, targets, or benchmark metrics. |
|
|
| ## Coverage |
|
|
| - Benchmark: ProteinGym DMS zero-shot substitutions |
| - Assays: 217 |
| - Variants: 2,465,767 |
| - Per-assay score column: `cytolexmuta` |
| - Score direction: higher is better |
|
|
| ## Frozen performance |
|
|
| - Average Spearman: 0.5347273342803031 |
| - Official rounded score: 0.535 |
| - Activity: 0.524200 |
| - Binding: 0.469375 |
| - Expression: 0.536833 |
| - OrganismalFitness: 0.490910 |
| - Stability: 0.652318 |
|
|
| ## Files |
|
|
| - `cytolexmuta_scores_full217.tar.gz`: 217 per-assay CSV files, each with columns `mutant,cytolexmuta`. |
| - `full217_cytolexmuta_scores.csv.gz`: combined full217 prediction table with `row_index,DMS_id,mutant,cytolexmuta`. |
| - `summary.json`: package manifest and validation summary. |
| - `METHOD_CARD.md`, `pr_body.md`, `issue_body.md`: method and ProteinGym submission drafts. |
|
|
| ## License and upstream note |
|
|
| This dataset is provided for benchmark review and reproducibility. Upstream model/code/data licenses remain with their respective authors. GEMME/JET2 runtime artifacts are not redistributed here. |
|
|
