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the synthesis methods and the use of nanostructures for various applications have been a very lucrative topic in the last decade. these efforts have lead to discoveries of unknown phenomena and/or new approaches to explain with precision the observed experimental and theoretical facts from the macro / micro world. when... | the phenomenon of persistent photoconductivity is elusive and has not been addressed to an extent to attract attention both in micro and nanoscale devices due to unavailability of clear material systems and device configurations capable of providing comprehensive information. in this work, we have employed a nanostruct... |
they produce mature progenies to replace short - lived cells and repair tissue damage while maintaining their numbers through self - renewing divisions (simons and clevers, 2011). many tissue stem cells are relatively quiescent, which delays their attrition and minimizes the accumulation of deleterious mutations (orfor... | summarythe activity of adult stem cells is regulated by signals emanating from the surrounding tissue. many niche signals have been identified, but it is unclear how they influence the choice of stem cells to remain quiescent or divide. here we show that when stem cells of the adult hippocampus receive activating signa... |
methods and any associated references are available in the online version of the paper at http://www.nature.com / naturemedicine/. | t - cell acute lymphoblastic leukemia (t - all) is an immature hematopoietic malignancy driven mainly by oncogenic activation of notch1 signaling1. in this study we report the presence of loss - of - function mutations and deletions of ezh2 and suz12 genes, encoding critical components of the polycomb repressive comple... |
elimination of vertical transmission of hiv is a global priority, yet progress remains marred by severe disparities across regions. while it is almost a reality in developed country settings, in many resource - poor settings, only an estimated 15% to 30% of eligible women complete the prevention of mother to child tran... | introductionnumerous barriers to optimal uptake of prevention of mother to child transmission (pmtct) services occur at community level (i.e., outside the healthcare setting). to achieve elimination of paediatric hiv, therefore, interventions must also work within communities to address these barriers and increase serv... |
restoration of a tooth with extensive destruction may require a post to retain the restorative material securely and promote an even distribution of forces in the root.1234 a post does not strengthen the tooth, thus the decision to use a post is dependent on whether the remaining tooth structure is sufficient to retain... | purposethe aim of this in vitro study was to evaluate the mechanical properties (bending strength and hardness) of seven different fiber reinforced composite posts, in relation to their microstructural characteristics.materials and methodstwo hundred eighty posts were divided into seven groups of 40, one group for each... |
additional -globin genes in sheep might produce extra -globin chains and, consequently, the subject carrying triplicated () or quadruplicated () haplotypes may exhibit different hematological phenotypes when compared to the normal duplicated () homozygotes (nn). both and heterozygous (nd) and and homozygous (dd) indivi... | |
diabetes mellitus is a growing health problem worldwide causing severe and costly complications including blindness, cardiac and kidney diseases (1). according to shaw (2010), the world prevalence of diabetes among adults will increase to 7.7%, and affect 439 million adults by 2030. between 2010 and 2030, there will b... | objective(s):ethnopharmacological field surveys demonstrated that many plants, such as gentiana olivieri, helichrysum graveolens, helichrysum plicatum ssp. plicatum, juniperus oxycedrus ssp. oxycedrus, juniperus communis var. saxatilis, viscum album (ssp. album, ssp. austriacum), are used as traditional medicine for di... |
the incidence of malignant melanoma has been increasing by 2.6% annually over the last decade, with approximately 76,790 new cases resulting in 9,480 deaths in 2013. additionally, melanoma is one of the most common forms of cancer in young adults and represents a significant health concern, particularly in terms of yea... | melanoma is a malignancy of melanocytes or pigment - producing cells located predominantly in the skin. it is less common than other skin cancers but causes the greatest number of skin cancer - related deaths worldwide. the incidence of melanoma continues to increase and early detection is the most promising means of d... |
amblyopia is a developmental ocular disorder characterized by a unilateral or bilateral visual deficiency that is out of proportion with any structural abnormalities that are present in the eye [14 ]., extensive neuroimaging studies have found decreased gray / white matter volumes [57 ] and reduced functional activatio... | amblyopia, which usually occurs during early childhood and results in poor or blurred vision, is a disorder of the visual system that is characterized by a deficiency in an otherwise physically normal eye or by a deficiency that is out of proportion with the structural or functional abnormalities of the eye. our previo... |
to meet the wide variety of consulting needs that undergraduate neuroscience programs and departments have, the pdcs maintains a database of faculty consultants with expertise in a broad range of areas. specific areas include (but are not limited to) : curriculum (evaluation, development, designing / improving special ... | in 2007 fun established the fun program and department consultations service, or fun - pdcs. since that founding, the service has provided numerous consultation recommendations to undergraduate programs seeking assistance with external program reviews, designing and improving courses and many other programmatic needs. ... |
youth violence is a major international public health concern [1, 2 ]. in nearly every region of the world, adolescents and young adults comprise the majority of violent death victims, resulting in significant losses in the world 's most productive citizens. indeed, global surveillance efforts estimate that an average ... | objective. using nationally representative data, this study examined the prevalence of very frequent physical fighting (12 times per year) among youth in 27 countries and cities. frequent physical fighting has rarely been reported in the previous literature despite the implications for research and practice. methods. a... |
forty patients with aphakia were randomized and allocated into anterior chamber (group 1) and retropupillary implantation (group 2) group. group one received artisan iris - claw iol (ophtec, groningen, the netherlands) implantation over the iris, and group 2 received retropupillary artisan iol implantation. this study ... | purpose : to compare the outcomes of anterior chamber and retropupillary implantation of iris - claw artisan intraocular lenses (iol).design : prospective, randomized, single - blinded study.patients and methods : forty eyes of forty aphakic patients were enrolled. patients were randomized into two groups. each group i... |
ak is a 61-year - old woman who developed right upper quadrant pain and underwent a laparoscopic cholecystectomy on january 22, 2013. operative findings included a porcelain gallbladder, an apparent liver metastasis, and peritoneal metastases. the gallbladder was removed and one liver lesion was biopsied. immunohistoch... | trastuzumab is a monoclonal antibody targeting her-2. her-2 overexpression has been described in gallbladder cancer and in cholangiocarcinoma. this report describes the first case of a patient with her-2 overexpressing metastatic gallbladder adenocarcinoma and responding radiographically and biochemically to trastuzuma... |
proper functioning of the central nervous system requires a fine balance between excitatory and inhibitory neurotransmission. cortical inhibitory neurons, classified by their expression of the inhibitory neurotransmitter gamma aminobutyric acid (gaba), comprise 1025% of neurons in the cortex and are the primary source ... | cortical inhibitory neurons play crucial roles in regulating excitatory synaptic networks and cognitive function and aberrant development of these cells have been linked to neurodevelopmental disorders. the secreted neurotrophic factor neuregulin-1 (nrg1) and its receptor erbb4 are established regulators of inhibitory ... |
leishmaniasis is a vector - borne disease caused by obligate intramacrophage protozoan parasites of the genus leishmania [1, 2 ]. the infecting leishmania species determines the clinical presentation of disease, of which there are three dominant clinical forms : cutaneous leishmaniasis (cl), mucocutaneous leishmaniasis... | in an attempt to investigate the effects of treatment of human leishmaniasis, the cytokines produced by peripheral blood mononuclear cells (pbmcs) of patients with cutaneous leishmaniasis (cl) and mucocutaneous leishmaniasis (mcl) under treatment with amphotericin b were determined during the active disease from cocult... |
the off - label use of drugs in paediatrics, i.e. the prescription of drugs which are not licensed for a specific age or mode of application, is often described as an ethical problem [13, 6, 10 ]. they need long - term antihypertensive therapy with drugs which, however, are not approved for children so far. drugs of fi... | off - label drug use in paediatrics is associated with an increased risk of adverse drug reactions. any risk benefit analysis has to be based on value judgments that should include parents ' views. however, nothing is known so far about the parents ' perspective on this critical issue. therefore, a quantitative survey ... |
this was a cross - sectional questionnaire study conducted on 1514 participants, which included faculty mds and bds and pgs in 40 dental colleges of india selected by multistage random sampling. the list of all dental colleges in india was obtained from the website of dental council of india. the survey instrument was ... | objective : research in the dental field is progressing at mightier speed worldwide, but an unfortunately representation of india at this platform is negligible. the present study was undertaken to unearth the barriers for dental research among dental professionals in indian scenario.materials and methods : a cross - s... |
cervicitis is defined clinically by the presence of either mucopurulent discharge or easily induced bleeding at the endocervical os, more subtle signs include edema of the cervical ectropion (edematous ectopy) and the presence of an elevated number of polymorphonuclear leukocytes, as detected by gram staining of a smea... | infection with genital herpes simplex virus (hsv) remains a common viral sexually transmitted disease, often subclinical and a major worldwide problem of women of reproductive age group. herpes cervicitis is an unusual presentation of herpes simplex virus infection in females. the finding of herpes cervicitis on routin... |
we developed an ordinary differential equation simulation model for hiv testing and treatment among msm in san francisco extending previous models [1, 4, 5 ]. we tested 3 art expansion strategies : (1) treatment of all individuals currently receiving hiv care with cd4 cell counts 500 cells / mm, cd4 cell count of 35050... | modeling of expanding antiretroviral treatment to all hiv infected adults already in care in san francisco predicts reductions in new hiv infections at 5 years of 59% among men who have sex with men (msm). addition of annual hiv testing for msm to universal treatment decreases new infections by 76%. |
the doctors said that it was puerperal fever and that it was ninety - nine chances in a hundred it would end in death. the whole day long there was fever, delirium, and unconsciousness. at midnight leo tolstoy 's anna karenina sepsis syndromes, which account for up to 50% of deaths in intensive care units (icus), are a... | sepsis is a major cause of mortality and morbidity in intensive care units. organ dysfunction is triggered by inflammatory insults and tissue hypoperfusion. the brain plays a pivotal role in sepsis, acting as both a mediator of the immune response and a target for the pathologic process. the measurement of brain dysfun... |
dipeptidyl peptidase4 (dpp4) inhibitors belong to a novel class of antidiabetic agents that increase the incretin hormones, glucagonlike peptide1 (glp1) and glucosedependent insulinotropic polypeptide (gip). sitagliptin is the first dpp4 inhibitor in japan, where it has been available for approximately 2 years. the ora... | abstract (j diabetes invest, doi : 10.1111/j.20401124.2012.00221.x, 2012) aims / introduction : to determine the efficacy and safety of sitagliptin monotherapy and combination therapy in japanese type 2 diabetes patients after 3 months therapy.materials and methods : a retrospective, observational study of 741 type 2 d... |
complete decompression and reconstruction of the anterior and middle portions of the spine column are facilitated via anterior surgery, which is important for neurological recovery and reestablishing immediate and permanent spine stability. after subtotal corpectomy, spinal canal could be thoroughly decompressed, and s... | background : subsidence and late fusion are commonly observed in anterior subtotal corpectomy and reconstruction for treating thoracolumbar burst fractures. the subsidence rate of this surgical method was reported from 19.6% to 75% in the literatures, which would cause treatment failure. thus, an improvement of anterio... |
abdominal obesity, characterized by preferential accumulation of intra - abdominal adipose tissue (iat), contributes to cardiovascular and metabolic risk beyond the risk defined by body mass index [1, 2 ] thus, prevention of abdominal obesity is key to reducing cardiometabolic risk. preferential iat accumulation, as me... | we have previously shown that physical activity predicts intra - abdominal adipose tissue (iat), but it is unknown whether energy intake predicts iat independently of physical activity in a community - based, naturalistic environment. the association of energy intake with iat was explored cross - sectionally in women, ... |
primary carcinoma of the extrahepatic bile duct is a rare tumor that represents less than 1.0% of all malignant neoplasms and less than 3.0% of all the tumors of the gastrointestinal system1). most malignant tumors generated in the biliary tract are adenocarcinomas, and adenosquamous carcinoma is rare (3.0~4.7%). adeno... | most malignant tumors originating from the biliary tract are adenocarcinomas, and adenosqamous carcinoma of klatskin 's tumor is a very rare finding. an 83-yr - old man was admitted to our hospital because of jaundice. the abdominal computed tomography and magnetic resonance cholangiopancreatography revealed wall thick... |
microwave imaging has received significant attention in the research community during the last couple of decades as a modality that potentially could improve the diagnostics of, for example, breast cancer tumors. today the research has come to the stage where early clinical trials have been and are being performed, [36... | nonlinear microwave imaging heavily relies on an accurate numerical electromagnetic model of the antenna system. the model is used to simulate scattering data that is compared to its measured counterpart in order to reconstruct the image. in this paper an antenna system immersed in water is used to image different cano... |
imagine that you were asked to evaluate whether a new medicine produces an allergic reaction as a side effect. to accomplish this task, you are shown the individual medical records of a number of patients where you can find out whether each patient took the medicine and whether he / she suffered an allergic reaction. h... | abstract. decades of research in causal and contingency learning show that people s estimations of the degree of contingency between two events are easily biased by the relative probabilities of those two events. if two events co - occur frequently, then people tend to overestimate the strength of the contingency betwe... |
the incidence of occupational disease in mo has increased during the past decade, after a downwards trend during the preceding years. the incidence in 2006 was twice that in 1999, passing the level in rf. the most common causes (36.6%) of occupational disease were noise and vibration (8). musculoskeletal problems and d... | objectiveswe aimed to describe how work exposure and occupational health is assessed for mine workers in murmansk oblast, russia.study designa descriptive study based on current practice, laws and available literature.methodsthe information and data were obtained from scientific publications, reports, regional and fede... |
healthy volunteers were recruited from the general population of the delaware valley (10). the protocol was approved by the institutional review board of the university of pennsylvania, and subjects gave written informed consent. briefly, criteria included healthy men or nonpregnant / lactating women, aged 1840 years, ... | objectivean emerging model of metabolic syndrome and type 2 diabetes is of adipose dysfunction with leukocyte recruitment into adipose leading to chronic inflammation and insulin resistance (ir). this study sought to explore potential mechanisms of inflammatory - induced ir in humans with a focus on adipose tissue.rese... |
the surveyed races were flat races on turf and dirt tracks held by the jra from january 1st, 2002, to december 31st, 2010. the race lengths were 1,200, 1,400, 1,600, 1,800 and 2,000 m on turf and 1,000, 1,200, 1,400, 1,700 and 1,800 m on dirt. these were the respective top 5 races in terms of their number of starters. ... | abstractthe running performance of thoroughbred racehorses has been reported to peak when they are between 4 and 5 years old. however, changes in their racing speed by month or season have not been reported. the purposes of this study were to reveal the average racing speed of thoroughbreds, and observe changes in thei... |
thirty patients were diagnosed with iac in the peking union medical college hospital (pumch) from january 2011 to september 2014, during which 275 patients were diagnosed with cca. all patients were retrospectively reviewed and information was collected including their sex, age, symptoms, weight loss (decreased > 5% wi... | background and aim : immunoglobulin g4-associated cholangitis (iac) shares many similar symptoms with cholangiocarcinoma (cca). however, the treatment and the prognosis are substantially different. this study aimed to identify the important markers for the differential diagnosis of these 2 diseases.methods:thirty iac p... |
the first core functionality of the laglidadg homing endonuclease database and engineering server (lahedes) resource is an updateable collection of wild - type and engineered lhes that have been shown to cleave precisely defined dna sequences corresponding to their target sites in original host gene, and for which the ... | laglidadg homing endonucleases (lhes) are dna cleaving enzymes, also termed meganucleases that are employed as gene - targeting reagents. this use of lhes requires that their dna specificity be altered to match sequences in genomic targets. the choice of the most appropriate lhe to target a particular gene is facilitat... |
the art world changed forever in 1945, the year that jackson pollock moved from downtown manhattan to the countryside of long island, new york. friends recall the many hours that pollock spent on the back porch of his new house, staring out at the scenery as if assimilating the natural shapes surrounding him (see figur... | fractals have been very successful in quantifying the visual complexity exhibited by many natural patterns, and have captured the imagination of scientists and artists alike. our research has shown that the poured patterns of the american abstract painter jackson pollock are also fractal. this discovery raises an intri... |
cardiovascular disease is the leading cause of death in patients with chronic kidney disease (ckd). cardiovascular mortality in patients with end - stage renal disease (esrd) is 10 to 20 times higher than in the general population. classic risk factors (diabetes mellitus, smoking, dyslipidemia, high blood pressure, sed... | background and aimscardiovascular (cv) disease is the leading cause of morbidity and mortality in hemodialysis (hd) patients. kidney disease is associated with increased oxidative stress (os), a nontraditional cv risk factor. few studies evaluate the effect of os markers on cv events (cve) and survival in hd patients. ... |
cp describes a group of permanent disorders of the development of movement and posture, causing activity limitation, that are attributed to nonprogressive disturbances that occurred in the developing fetal or infant brain. the motor disorders of cp are often accompanied by disturbances of sensation, perception, cogniti... | aim and objective : cerebral palsy (cp) is the most common motor disability in childhood. this study aimed to describe clinical spectrum, comorbidities, and risk factors associated with cp children.materials and methods : this hospital - based observational study was conducted in tertiary level hospital in jaipur inclu... |
the study population consisted of all consecutive patients undergoing ccta in our institution between 1 december 2003 and 29 february 2008, for evaluation of suspected cad. exclusion criteria were 1) typical angina pectoris, 2) a history of myocardial infarction including electrocardiographic signs of a silent myocardi... | objectivediabetic patients have a high prevalence of coronary artery disease (cad), but timely diagnosis of cad remains challenging. we assessed the ability of coronary computed tomography angiography (ccta) to detect cad in diabetic patients and to predict subsequent cardiac events.research design and methodswe analyz... |
the postinfectious irritable bowel syndrome is characterized by the sudden onset of symptoms mentioned in the diagnostic criteria for irritable bowel syndrome (with rome iv criteria being the most recently defined). they appear following an episode of acute infectious gastroenteritis characterized by two or more of the... | after acute infectious gastroenteritis, up to thirty percent of patients present prolonged gastrointestinal symptoms and a part of those affected patients can have the diagnostic criteria for postinfectious irritable bowel syndrome.treatment is symptom directed rather than curative and includes agents prescribed for th... |
all protocols and experiments were approved by the washington university animals studies committee (protocol 20150285) and followed national institutes of health animal care guidelines. male c57bl/6 mice, tsc1 and raptor mice, were purchased from the jackson laboratory (bar harbor, me). villin cre mice were obtained vi... | background & aimsintestinal adaptation is a compensatory response to the massive loss of small intestine after surgical resection. we investigated the role of intestinal epithelial cell specific mammalian target of rapamycin complex 1 (i - mtorc1) in intestinal adaptation after massive small bowel resection (sbr).metho... |
it is estimated that half a million cases occur worldwide annually, making primary liver cancer the fifth most common malignancy in men and the ninth in women [16 ]. hepatocellular carcinoma (hcc) accounts for 85% to 90% of primary liver cancers and the age - adjusted hcc mortality rate has increased in recent decades ... | backgroundthe incidence of hepatocellular carcinoma (hcc) continues to increase in japan, but the clinical characteristics of japanese patients with hcc have not been well described. the aim of this study was to determine the frequencies and utilities of elevated -fetoprotein (afp) and des - gamma - carboxy prothrombin... |
the ovaries are the most common sites affected, but endometriosis can also involve the gastrointestinal tract, urinary tract, chest, and soft tissues. endometriosis of the chest is uncommon, and the diagnosis is usually established on clinical grounds. endometrial tissue may involve the pleura by migrating from the per... | chest pain is a rare sign of thoracal endometriosis associated with endometrioma of the tubo - ovarian endometrioma. we report the case periodic episodes of chest pain concurrent with menstruation in a 35-year - old female, in which ovarian endometrioma was diagnosed and left - sided oophorectomy was performed. after s... |
bfgfbasic fibroblast growth factorcafcancer - associated fibroblastnatnormal fibroblast basic fibroblast growth factor cancer - associated fibroblast although genetic mutations in tumor cells are the primary drivers of tumorigenesis, stromal cells in the tumor microenvironment, including fibroblasts, immune cells, and ... | abstractcancer - associated fibroblasts (cafs) are major participants in the crosstalk between tumor cells and their microenvironment. cafs provide not only multiple soluble factors but also metabolic fuels to promote tumor growth, invasion, and metastasis. we discuss recent developments delineating the effects of meta... |
radicular back pain is an important public health issue that can result in long term disability and poor quality of life. conservative therapy is the initial treatment of choice, but fails to provide relief in a substantial number of patients. central and foraminal stenosis with entrapment of descending and/or exiting ... | background : spinal stenosis of the thoracic spine is less common than that of the cervical and lumbar regions. due to the close proximity to thoracic and abdominal organs, surgical operations can be difficult and carry a greater risk of complications. the most efficacious intervention for thoracic stenosis, whether ce... |
in 2000, the 24 member boards of the american board of medical specialties, including the american board of pathology, agreed to evolve their recertification programs toward continuous professional development to ensure that physicians are committed to lifelong learning and competency in their specialty areas (1, 2). m... | we examined how pathologists process their perceptions of how their interpretations on diagnoses for breast pathology cases agree with a reference standard. to accomplish this, we created an individualized self - directed continuing medical education program that showed pathologists interpreting breast specimens how th... |
hek293 cells stably expressing human glp-1 receptor and a 3x - cre luciferase reporter were grown at 37c in 5% co2 in dulbecco 's modified eagle 's medium-31053 (invitrogen, carlsbad, ca) supplemented with 0.5% fbs, 2 mmol / l l - glutamine, 50 units / ml penicillin, 50 g / ml streptomycin, and 20 mmol / l hepes. for c... | objectivethe clinical effectiveness of parenterally - administered glucagon - like peptide-1 (glp-1) mimetics to improve glucose control in patients suffering from type 2 diabetes strongly supports discovery pursuits aimed at identifying and developing orally active, small molecule glp-1 receptor agonists. the purpose ... |
multiple sclerosis (ms) is an inflammatory disease characterized by damage to the myelin sheath surrounding neurons in the central nervous system (cns). this damage may be progressive, or it may wax and wane with periods of relapse and remission. motor, somatosensory, visual, cognitive, and psychiatric deficits may occ... | purposealthough smoking is known to cause various symptoms in multiple sclerosis (ms) patients, there have been no reports regarding the relationship between smoking and cognitive impairment in ms. studying the effects of cigarette smoking in ms patients is imperative as there is a high prevalence of cognitive impairme... |
glomerular disease, characterized by focal and segmental glomerulosclerosis histology (fsgs), is a challenging disease to treat due to its frequent relapsing unremitting course and high rate of progression to end - stage renal disease (esrd). for unclear reasons, fsgs has a rising incidence, now becoming a common cause... | mutations in the inverted formin 2 gene (inf2) have recently been identified as the most common cause of autosomal dominant focal and segmental glomerulosclerosis (fsgs). in order to quantify the contribution of various genes contributing to fsgs, we sequenced inf2 where all mutations have previously been described (ex... |
a simulation for each dipeptide (in their zwitterionic form) was set up using the gromacs molecular dynamics package. a cubic box with 300 dipeptides, placed randomly with a minimum distance of 3 between them, was solvated in standard martini cg water (four water molecules per bead) to a final concentration of 0.4 m. a... | several short peptide sequences are known to self - assemble into supramolecular nanostructures with interesting properties. in this study, coarse - grained molecular dynamics is employed to rapidly screen all 400 dipeptide combinations and predict their ability to aggregate as a potential precursor to their self - ass... |
alzheimer 's disease (ad) is a progressive brain disease affecting the elderly population, causing problems with memory, thought, and behavior. approximately 25% of ad cases are familial (fad), caused by autosomal dominant mutations in amyloid precursor protein (app) or the presenilin (ps1, ps2) genes [13 ], while the ... | beta - secretase (bace1) is the major enzyme participating in generation of toxic amyloid - beta (a) peptides, identified in amyloid plaques of alzheimer 's disease (ad) brains. its downregulation results in decreasing secretion of a. thus, bace1 silencing by rnai represents possible strategy for antiamyloid therapy in... |
phenylketonuria (pku ; omim 261600) is defined as an autosomal recessive genetic inborn error of phenylalanine (phe) metabolism (1). insufficiency in the hepatic specific enzyme, phenylalanine- 4-hydroxylase (pah) (ec 1.14.16.1) leads to hyperphenylalaninemia that is associated with the pku (1). deficiency of the pah e... | objective(s):phenylketonuria (pku) is a genetic inborn error of phenylalanine (phe) metabolism resulting from insufficiency in the hepatic enzyme, phenylalanine hydroxylase (pah), which leads to elevated levels of phe in the blood. the present study was carried out for mutation analysis of the pah gene in west azerbaij... |
parkinson 's disease (pd) is one of the most common neuro - degenerative disorders characterized by tremor, bradykinesia, rigidity and postural instability as well as several nonmotor features including dementia and depression. the exact pathophysiology of the disease is largely unknown though oxidative stress and mito... | background : patients with psoriasis might be at a higher risk of developing parkinson 's disease (pd) as a result of the detrimental effect of chronic inflammation on the neuronal tissue. this meta - analysis aimed to investigate this risk by comprehensively reviewing all available data.methods:we conducted a systemat... |
even though there have been continual advances in neonatal care and a decline in mortality of preterm infants in the past several decades, the incidence of severe long - term sequelae such as chronic lung disease and neurodevelopmental disability in survivors remains high, particularly in newborns delivered at early ge... | objective : this study aimed to determine the impact of maternal cervical incompetence (with or without mcdonald cerclage) on mortality and morbidity of preterm infant with birth weight < 2000g.methods:581 neonates were eligible for this study, 79 with cervical incompetence and 502 without it (control). incidences of n... |
glaucoma is a progressive, vision - threatening disease characterized by functional and structural ocular abnormalities and is commonly associated with increased intraocular pressure (iop). in the last few years, clinical perspectives have evolved to define glaucoma as a collection of diseases with varied etiologies le... | backgroundthe purpose of this study was to evaluate the safety and efficacy of a long - term, twice - daily brinzolamide 1%/timolol 0.5% fixed combination ophthalmic suspension (brinz / tim - fc) in japanese patients with open - angle glaucoma (primary open - angle, normal - tension, exfoliation, or pigmentary) or ocul... |
leptin is a hormone that was initially found to be synthesized by white adipocytes and has a strong correlation with the amount of adipose tissue and with body mass index (bmi). leptin was first discovered in 1994 and found to act as a signal for the central nervous system to inhibit food intake and to stimulate energy... | obesity is an important risk factor for osteoarthritis (oa) in weight - bearing joints, but also in hand joints, pointing to an obesity - related metabolic factor that influences on the pathogenesis of oa. leptin is an adipokine regulating energy balance, and it has recently been related also to arthritis and inflammat... |
iranian traditional medicine (itm) is rich in intact information about plants that have been used to treat various diseases, especially skin disorders. world plant biodiversity is the best source of herbal medicine and still about 60%-80% world population trust on plant based medicines which are being used since the an... | herbal therapy was the common treatment prescribed by iranian physicians for wound healing. zemad was the most ancient pharmaceutical dosage form used in iranian traditional medicine (itm) for skin diseases. in the present research, formulation of a traditionally used poly herbal paste (php) for wound healing was perfo... |
monoclonal immunoglobulin deposition disease, (midd) is a systemic disease characterized by non - fibrillar, congo red negative deposition of monoclonal immunoglobulins in the various organs of the body. midd is of three types depending on the composition of the deposits : light chain deposition disease (lcdd), heavy c... | monoclonal immunoglobulin deposition disease (midd) is an uncommon disease with a peak incidence between the 5th and 6th decades of life. it is characterized by non - fibrillar, congo red negative deposition of monoclonal immunoglobulins in various organs, including in the kidneys. midd can be of three types depending ... |
several governmental and scientific bodies are dedicated to ensuring protection of the public from radiation. the international commission on radiological protection was created in 1928 by the international congress of radiology to advance the science of radiation protection for the public by publishing peer reviewed r... | potassium iodide (ki) is recommended as an emergency treatment for exposure to radioiodines, most commonly associated with nuclear detonation or mishaps at nuclear power plants. protecting the thyroid gland of infants and children remains a priority because of increased incidence of thyroid cancer in the young exposed ... |
current hiv prevention strategies (condoms and abstinence) force hiv - serodiscordant couples to choose between risking hiv transmission to a partner, or accepting childlessness [112 ]. behavioral strategies (home artificial insemination, sex without condoms limited to peak fertility), male circumcision [1315 ], antire... | background. understanding hiv - infected patient experiences and perceptions of reproductive counseling in the health care context is critical to inform design of effective pharmaco - behavioral interventions that minimize periconception hiv risk and support hiv - affected couples to realize their fertility goals. meth... |
the objective signs and subjective symptoms of dry eye fluctuate greatly across patient populations, creating a significant challenge for the clinician to diagnose and treat the condition effectively. a more recent area of study in dry eye is the implications for visual function. the decreased blink rate experienced du... | objective : the purpose of the current study was to evaluate the effects of two marketed ocular lubricants on the visual decay in dry eye patients using the inter - blink interval visual acuity decay (ivad) test.methods:this controlled, randomized, double - masked crossover study compared the effects of a polyethylene ... |
the early and late mortality after acute myocardial infarction (ami) is declining, but cardiovascular disease (cvd) is still one of the leading causes of morbidity and death in the western world. ischemic heart disease is a feared, but often inevitable complication of atherosclerosis, the main underlying cause of myoca... | background. matrix metalloproteinase-9 (mmp-9), regulated by tissue inhibitor of metalloproteinase-9 (timp-1) and the extracellular matrix metalloproteinase inducer (emmprin), contributes to plaque instability. autologous stem cells from bone marrow (mbmc) treatment are suggested to reduce myocardial damage ; however, ... |
tarsal plates removed from fresh cadaver 's upper and lower eyelids of a healthy caucasian female donor (36 years of age) were obtained from mid - america transplant (st. louis, mo, usa). the use of human tissue in research conformed to the provisions of the declaration of helsinki and was exempted by the washington un... | purposelittle is known about the signaling mechanisms controlling meibomian gland (mg) homeostasis and the pathogenic processes leading to mg atrophy and dysfunction in dry eye disease (ded). we investigated the role of fibroblast growth factor receptor 2 (fgfr2) in the mg homeostasis of adult mice.methodsa triple tran... |
assessment of functional capacity is important for identifying the physical implications of stroke, since it is currently considered the main cause of serious long - term disability in adults1, impairing physical, psychological, and social functions2. after a stroke, individuals remain with several residual impairments... | [purpose ] the aim of this study was to investigate the associations between self - reported and valid performance - based measures of functional capacity in individuals with chronic stroke. [subjects and methods ] self - reported measures of functional capacity of 31 individuals with chronic stroke were assessed by th... |
dendritic cells (dcs) are professional antigen - presenting cells that possess the unique capacity to activate and prime naive cd4 and cd8 t cells. they form a heterogeneous population consisting of specialized dc subsets that differ in their surface marker expression, molecular phenotype, and antigen - processing and ... | dendritic cells (dcs) are central players of immune responses ; they become activated upon infection or inflammation and migrate to lymph nodes, where they can initiate an antigen - specific immune response by activating naive t cells. two major types of naturally occurring dcs circulate in peripheral blood, namely, my... |
unless otherwise noted, all reagents were purchased from sigma aldrich (st. louis, mo, usa) and used without further purification. boc - gly, merrifield resin and boc - lys - ome were purchased from bachem (torrance, ca, usa). boc - ala - oh, boc - lys - oh, boc - phe - oh and boc - val - oh were purchased from novabio... | the need for post - synthetic modifications and reactive prosthetic groups has long been a limiting factor in the synthesis and study of peptidic and peptidomimetic imaging agents. in this regard, the application of biologically and chemically orthogonal reactions to the design and development of novel radiotracers has... |
recently, the belgian government issued a bill regulating the organisation of and minimal requirements for specialist breast units (kb, 2007). the criteria were much based on a eusoma (european society of mastology) position paper (eusoma, 2000 ; perry, 2001), a text which was adopted in a resolution on breast cancer b... | aim : criteria for future accreditation of breast cancer centres in belgium will be mainly based on the case load per surgeon or per centre. we would like to argue that the prospective collection of relevant data and the analysis of treatment related outcome derived from these data is feasible and should be the ultimat... |
spinocerebellar ataxias (scas) are autosomal - dominant neurodegenerative diseases that are clinically and genetically heterogeneous. scas are characterized by a range of neurological symptoms, including loss of balance and motor coordination, which are caused by progressive dysfunction of the cerebellum and its affere... | backgroundspinocerebellar ataxias (scas) are autosomal - dominant neurodegenerative diseases that are clinically and genetically heterogeneous. scas are characterized by a range of neurological symptoms. sca12 is an autosomal - dominant (ad) ataxia caused by a cag repeat expansion mutation in a presumed promoter region... |
traditionally, this has been via the abdominal or vaginal routes. in the present era, hysterectomies are undertaken using minimal access techniques. total laparoscopic hysterectomy (tlh) is performed entirely by the laparoscopic route, including closure of the vaginal vault, with the uterus being removed vaginally or b... | we compared the duration of surgery, blood loss, and complications between patients in whom both uterine arteries were ligated at the beginning of total laparoscopic hysterectomy (tlh) and patients in whom ligation was done after cornual pedicle. using a prospective study in a gynecologic laparoscopic center, a total o... |
when multiple hypotheses are tested in a single experiment, the risk of type i error is increased and with it the risk of promulgating spurious significant findings.[13 ] the likelihood of obtaining a false positive result increases proportional to the number of tests performed. for example, the probability of obtainin... | increased type i error resulting from multiple statistical comparisons remains a common problem in the scientific literature. this may result in the reporting and promulgation of spurious findings. one approach to this problem is to correct groups of p - values for family - wide significance using a bonferroni correcti... |
the most ideal outcomes for tumor targeted therapy are improved patient survival and minimal adverse effects on normal tissues. drugs that can specifically home to a cancer cell based on a surface receptor have helped to address that goal with the advent of monoclonal antibody therapy. rituximab, directed against the c... | epithelial cell adhesion molecule (epcam) is a type i transmembrane glycoprotein overexpressed in human epithelioma but with relatively low expression in normal epithelial tissues. to exploit this differential expression pattern for targeted cancer therapy, an epcam - targeted immunotoxin was developed and its antitumo... |
staphylococcus aureus is an important food - borne pathogen involved in a variety of invasive diseases (1). it produces many toxins as well as non - toxic enzymes and can facilitate bacterial attack and proliferation in the body of host (2). some strains produce staphylococcal enterotoxins (ses) that can cause food poi... | background and objectivesstaphylococcal food poisoning is a gastrointestinal disease, which is caused by consumption of contaminated food with enterotoxins produced by staphylococcus aureus (ses). milk and its products are known sources of food borne diseases. this study was carried out to evaluate the prevalence of en... |
bisphosphonate - related osteonecrosis of the jaw (bronj) is currently defined as an area of exposed bone in the maxillofacial region that has persisted for more than 8 weeks in a patient on previous or current treatment with a bisphosphonate and without history of radiation therapy to the jaws. despite this definition... | purpose. to report the efficacy of conservative surgical treatment for stage i bisphosphonate - related osteonecrosis of the jaw (bronj). materials and methods. this study reports the clinical outcomes of 63 patients treated for bronj stage i (according to ruggiero 's staging system) at the oral pathology and laser - a... |
preanalytical problems are the major source of laboratory errors, accounting for 6070% of total errors encountered within the total testing process. preanalytical errors not only may lead to spurious test results, but also, more importantly, may influence patient care, even dramatically. the immunosuppressive drugs tac... | tacrolimus and cyclosporine a are immunosuppressant drugs with narrow therapeutic windows. the aim of this study was to investigate the stability of tacrolimus and cyclosporin a levels in whole blood samples under different storage conditions. whole blood samples were obtained from 15 patients receiving tacrolimus and ... |
a group of 14 university hospitals participated in this study and 72 patients were recruited between 1992 and 2006. individuals with confirmed hnf1a - mutated hca who underwent curative resection of the tumor(s) were eligible for inclusion in this study. the mean age of the patients was 37.5 years (ranging from 14 to 6... | objectivematurity onset diabetes of the young type 3 (mody3) is a consequence of heterozygous germline mutation in hnf1a. a subtype of hepatocellular adenoma (hca) is also caused by biallelic somatic hnf1a mutations (h - hca), and rare hca may be related to mody3. to better understand a relationship between the develop... |
along with the increase in the prevalence of type 1 diabetes mellitus (t1 dm) the number of patients with chronic vascular complications will rise significantly [13 ]. many trials have also shown that the main determinants of the vessel damage in the course of diabetes are hyperglycemia and diabetes duration [79 ]. dia... | the aim of this study was to evaluate the relationship between serum transforming growth factor 1 (tgf-1) concentrations and the duration of type 1 diabetes mellitus (t1 dm) in children and adolescents. one hundred and sixteen patients with t1 dm and 19 healthy controls were examined. serum tgf-1 concentrations were me... |
mesenchymal stromal cells, also referred to as mesenchymal stem cells (mscs), were first discovered in 1974. mscs are a heterogeneous group of cells mainly obtained from bone marrow (bm - msc), adipose tissue (adsc) and umbilical cord blood (ucb - msc). since the 90s, mscs have been investigated and used in cell - base... | abstractover the past 2 decades, therapies based on mesenchymal stem cells (msc) have been tested to treat several types of diseases in clinical studies, due to their potential for tissue repair and regeneration. currently, msc - based therapy is considered a biologically safe procedure, with the therapeutic results be... |
the prevalence of type 2 diabetes continues to rise and currently affects over 25 million americans and is estimated to reach 439 million adults worldwide by 2030 [1, 2 ]. along with this increase, adults aged 20 years (an estimated 79 million individuals) [3, 4 ]. furthermore, it is estimated that, among u.s. adults w... | to examine whether behavioral risk factors associated with diabetes (diet, bmi, waist circumference, physical activity, and sleep duration) are also related to both prediabetes and insulin resistance (ir), we used data from boston area community health (bach) survey (20102012, n = 3155). logistic and linear regression ... |
in a quasi - experimental study carried out in 2009 - 2010 academic year and 63 medical students from isfahan university of medical sciences studying in the 3 or 4 semester were recruited. thirty two students who chose the optional course of learning and study skills, were selected as the intervention group, while 31 s... | background : it has been demonstrated that educational programs that focus on study skills could improve learning strategies and academic success of university students. due to the important role of such supportive programs aimed at the fresh students, this survey was carried out to investigate the effectiveness of an ... |
as medical house officers who trained together in internal medicine in the 1980s, we (jnk, sal) believed we knew who provided the highest - quality care. the best interns were those who spun the urine, gram - stained the sputum, and wrote notes on late - night admissions before the sun rose the next morning. the best r... | for much of the twentieth century, quality of care was defined specifically in terms of physician characteristics and behaviors. high - quality physicians were well trained, knowledgeable, skillful, and compassionate. more recently, quality of care has been defined in terms of systems of care. high - quality organizati... |
according to the international headache society (ihs), classical trigeminal neuralgia (tn) is defined as a unilateral disorder characterized by brief electric shock - like pains, abrupt in onset and termination, limited to the distribution of one or more divisions of the trigeminal nerve. this is different from symptom... | it is unclear whether hypertension (htn) is a predisposing factor for the development of trigeminal neuralgia (tn). the purpose of this study was to determine the prevalence of htn in tn patients and controls at the usc orofacial pain and oral medicine center. a retrospective chart review was conducted from a database ... |
acute lymphoblastic leukemia (all) is a hematological malignant disorder caused by excessive production of leukocytes and is the most common malignancy in children, representing 2530% of all childhood malignancies. great improvements have been made in all treatment, with successful long - term survival rates of approxi... | great improvements have been made in acute lymphoblastic leukemia (all) treatment in the past decades, especially due to the use of l - asparaginase (l - asp). despite the significant success rate, several side effects mainly caused by toxicity, asparaginase silent inactivation, and cellular resistance, encourage an op... |
continuous ambulatory peritoneal dialysis (capd) is an important treatment option for patients with end - stage renal disease. although the rate of peritonitis has declined in recent years because of improvements in capd techniques, peritonitis remains the leading cause for discontinuation of capd. rothia muciliaginosa... | rothia muciliaginosa (r. mucilaginosa) is a facultative, gram - positive coccus that is considered to be part of the normal flora of the mouth and respiratory tract. there are sporadic reports of the organism causing endocarditis in patients with heart valve abnormalities, as well as meningitis, septicemia, and pneumon... |
the greatest association of helicobacter pylori (h. pylori) infection is with peptic ulcer disease. recently, the association between h. pylori and the development of gastric cancer is more clearly established than before, and by the announcement of the japanese society for helicobacter research, h. pylori eradication ... | a triple therapy based on a proton pump inhibitor (ppi), amoxicillin (ampc), and clarithromycin (cam) is recommended as a first - line therapy for helicobacter pylori (h. pylori) eradication and is widely used in japan. however, a decline in eradication rate associated with an increase in prevalence of cam resistance i... |
patients commonly present with acute cholinergic crisis, intermediate syndrome, or delayed polyneuropathy. they may also present with pancreatitis or hepatitis. here a 75-year - old homemaker presented to our emergency department following deliberate self - harm consuming around 100 ml chlorpyrifos along with small amo... | renal complications due to organophosphate poisoning are very rare. we are presenting a unique case of transient distal renal tubular acidosis due to organophosphate poisoning, which to the best of our knowledge is the first of its kind. an elderly female after deliberate self - harm with ingestion of chlorpyrifos had ... |
clefts of the anterior and posterior arch of the atlas are rare, but well - documented congenital anomalies [1, 2 ]. several reports attributed the aetiology of os odontoideum to an either embryologic, traumatic or vascular basis [35, 8 ]. we describe the unusual case of a combined midline cleft of the anterior and pos... | we report on the case of a 15-year - old adolescent who presented with a transient paraplegia and hyposensibility of the upper extremities after sustaining a minor hyperflexion trauma to the cervical spine. neuroimaging studies revealed atlantoaxial dislocation and ventral compression of the rostral spinal cord with in... |
the population of republic of korea is aging at an unprecedented fast rate. and per capita medical utilization due to geriatric illness has increased since 2002 in accordance with an aging society. among geriatric diseases in women, there are some diseases related to menopause in this aging society.1 average menopause ... | we are rapidly becoming an aging society, with the ongoing increase in challenges of the elderly. the age - related cognitive decline in accordance with aging society is of major importance in public health. recent studies have proved the impacts of sex - steroid hormone on the brain ; compliant with aging, menopause a... |
the wnt signaling pathway is known to play a key role in regulating cellular differentiation, proliferation, survival, and apoptosis [13 ]. wnt proteins are a highly conserved family of secreted lipid - modified cysteine - rich glycoproteins that activate signaling cascades inside the cell by binding to a member of the... | the wnt signaling pathway has been associated with many essential cell processes. this study aims to examine the effects of wnt signaling on proliferation of cultured hek293 t cells. cells were incubated with wnt3a, and the activation of the wnt pathway was followed by analysis of the level of the -catenin protein and ... |
nutrition security ensures optimal actualization of human resources and overall progress and development of a society and nation. malnutrition (both under- and overnutrition) is currently one of the biggest challenges being faced by the modern world. micronutrient deficiencies, more commonly referred to as hidden hunge... | iodine deficiency disorders (idd) constitute the single largest cause of preventable brain damage worldwide. majority of consequences of idd are invisible and irreversible but at the same time these are preventable. in india, the entire population is prone to idd due to deficiency of iodine in the soil of the subcontin... |
the isolation of pure, intact, and high - quality dna is very crucial for any molecular studies. however, dna isolation from plants is usually compromised by excessive contamination by secondary metabolites. the dna isolation methods need to be adjusted to each plant species and even to each plant tissue because of the... | mangroves and salt marsh species are known to synthesize a wide spectrum of polysaccharides and polyphenols including flavonoids and other secondary metabolites which interfere with the extraction of pure genomic dna. although a plethora of plant dna isolation protocols exist, extracting dna from mangroves and salt mar... |
the recent medical developments, including the increased use of chemotherapy drugs, white blood cell stimulants, and broad spectrum antibiotics, have improved the prognosis and life span of pediatric patients with neoplastic diseases. consequently, these patients often face lengthy periods of low immunity, undergo long... | background. pediatric patients with neoplastic diseases are more likely to develop nosocomial infections (nis). nis may prolong their hospital stay, and increase morbidity and mortality. objectives. the objectives of this study were to determine : (1) the incidence of nis, (2) sites of nis, (3) causal organisms, and (4... |
force measurements on a scaled hair - bundle model respected the physiological character of the liquid flow. the finite - element method provided approximate solutions to partial differential equations reflecting the hair bundle 's geometry. the velocity variable of the liquid was substituted by the time derivative of ... | the detection of sound begins when energy derived from an acoustic stimulus deflects the hair bundles atop hair cells1. as hair bundles move, the viscous friction between stereocilia and the surrounding liquid poses a fundamental physical challenge to the earfs high sensitivity and sharp frequency selectivity. part of ... |
thromboembolic stroke is a known complication of non - valvular atrial fibrillation (af). therefore, the need to prevent such occurrence is of paramount importance when treating patients with af. to aid in the assessment of stroke risk, several risk stratification schemes or clinical prediction rules the two most commo... | backgroundthe r2chads2 is a new prediction rule for stroke risk in atrial fibrillation (af) patients wherein r stands for renal risk. however, it was created from a cohort that excluded patients with advanced renal failure (defined as glomerular filtration rate of < 30 ml / min). our study extends the use of r2chads2 t... |
in europe, many countries will be confronted with aging populations in the coming decades. for example, it is estimated that in 2020, 28% of the french population will be over 60. a great way to resolve partially this difficulty is to encourage old people to be cared for in their own homes. this strategy presents two m... | this research takes place in the s(ma)2d project which proposes software architecture to monitor elderly people in their own homes. we want to build patterns dynamically from data about activity, movements, and physiological information of the monitored people. to achieve that, we propose a multiagent method of classif... |
according to the definition of world health organization (who), quality of life (qol) is the individual 's perception of his / her position in life in the context of the culture, value systems in which he / she lives, and in relation to his / her goals, expectations, standards and concerns. studies have identically sho... | background : although studies have demonstrated significant negative relationships between quality of life (qol), fatigue, and the most common psychological symptoms (depression, anxiety, stress), the main ambiguity of previous studies on qol is in the relative importance of these predictors. also, there is lack of ade... |
in recent years, we have witnessed a profound revolution in the way we approach and treat renal cell carcinoma (rcc). in a relatively short time (10 years, approximately), we have gone from a very limited range of therapeutic options [essentially limited to interferon (ifn) and, for the few patients fit enough to recei... | in the past ten years we have made exceptional progresses in the understanding of rcc biology, particularly by recognizing the crucial pathogenetic role of activation of the hif / vegf and mtor pathways. this has resulted in the successful clinical development of anti - angiogenic and mtor - targeted drugs, which have ... |
our initial sample consisted of 87 hcv+ participants who were recruited from several hepatology clinics and infectious disease clinics located throughout the greater los angeles catchment area. controls (n = 21) were recruited from the community through advertisements and flyers. all procedures received prior approval ... | objective : this study examined neurologic abnormalities (as measured by proton magnetic resonance spectroscopy imaging and diffusion tensor imaging), neurocognitive performance, and fatigue among a sample of adults with hepatitis c virus (hcv). we hypothesized that hcv+ individuals would demonstrate structural brain a... |
castleman 's disease (cd) or giant lymph node hyperplasia is a rare disorder first explained by castleman., in 1954. it can be unicentric or multicentric and mostly involves mediastinum (60%), retroperitoneum (11%), and axilla (4%). multicentric castleman 's disease (mcd) is manifested by generalized lymphadenopathy, h... | castleman 's disease (cd) or giant lymph node hyperplasia is a rare disorder that can be unicentric or multicentric. multicentric castleman 's disease (mcd) is manifested by generalized lymphadenopathy, hepatosplenomegaly, polyclonal hypergammaglobulinemia, hematological abnormality, and constitutional symptoms. human ... |
hepatocellular carcinoma (hcc) in adult men is the 5th most frequently diagnosed cancer worldwide, and is the 2nd leading cause of cancer - related death in the world. in adult women, it is the 7th most commonly diagnosed cancer and the 6th leading cause of cancer death. in the united states (us), the annual incidence ... | abstractstatins are associated with a reduced risk of hepatocellular carcinoma (hcc) and have the potential to be an adjuvant agent for hcc. in this study, we examined whether statin use is associated with additional benefits among patients who received curative treatments (cts) such as surgery, percutaneous ethanol in... |
patients with mild copd often use inhaled corticosteroids without a need for them. a clinical audit including spirometry was useful for identifying overuse of inhaled corticosteroids. asthma and chronic obstructive pulmonary disease (copd) are two separate diseases in terms of aetiology and pathophysiology, with differ... | background : inhaled glucocorticosteroids (ics) are first - line anti - inflammatory treatment in asthma, but not in chronic obstructive pulmonary disease (copd). to restrict ics use in copd to cases of severe disease, new terms for reimbursement of drug costs were introduced in norway in 2006, requiring a diagnosis of... |
steroid - responsive encephalopathy associated with subacute thyroiditis has, to our knowledge, not been reported previously. a 49-year - old woman was found collapsed and brought to our institution with decreased mentality, dysarthria, and gait disturbance. brain magnetic resonance imaging and angiography were normal ... | backgroundsteroid - responsive encephalopathy associated with subacute thyroiditis has, to our knowledge, not been reported previously.case reporta 49-year - old woman was found collapsed and brought to our institution with decreased mentality, dysarthria, and gait disturbance. brain magnetic resonance imaging and angi... |
evaluation of athletic hip pain routinely includes radiographs and magnetic resonance imaging (mri). computed tomography (ct) is applied at some centers and in certain clinical scenarios. although mri (arthrogram) alone can clearly define changes to labrum or cartilage, osseous pathology may be underappreciated. we pre... | femoro - acetabular impingement is a common cause of hip pain in young athletes. evaluation typically includes radiographs and magnetic resonance imaging. it is important to appreciate uncommon diagnoses and the role of complimentary imaging. this clinical vignette emphasizes the need complete imaging with ct in select... |
despite its world - wide omnipresence in soil, a. fumigatus had been considered asexual until studies of an aspergillus - like anamorph isolated from brazilian soil revealed a heterothallic breeding system, and the teleomorph neosartorya fumigata was described. we describe the first reported case of acute respiratory d... | we describe the first reported case of acute respiratory distress syndrome (ards) attributed to neosartorya udagawae infection. this mold grew rapidly in cultures of multiple respiratory specimens from a previously healthy 43-year - old woman. neosartorya spp. are a recently recognized cause of invasive disease in immu... |
nowadays, laboratory services play a major role in optimizing patient care. in some circumstances, increased laboratory use is allowed such as : 1. the duration of the patient s hospitalization can be shortened (1 - 4). previous test results are not available or the physician does not know about them (5 - 8), neverthel... | background : routine repeat testing of critical laboratory values is very common these days to increase their accuracy and to avoid reporting false or infeasible results. we figure that repeat testing of critical laboratory values has any benefits or not. methods : we examined 2233 repeated critical laboratory values i... |
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