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While the wireless connection is convenient, wired network performance is much more reliable. If your wireless hub is close enough to the Xbox 360 to making a wired connection between the hub and the Xbox 360 console is your ideal scenario. If wireless is your only option, I’ll walk you through the process of using your laptop to provide a connection to Xbox Live for your Xbox 360.
With your laptop connected wirelessly to your network access point, connect the wired network connection on your laptop to the wired connection port on the back of your Xbox 360 with any Ethernet cable.
Right-click your Wireless Network Connection and choose Properties from the list.
On the Advanced tab, check the box to Allow other network users to connect through this computer’s internet connection. In the Home Networking Connection dropdown list choose Local Area Connection. Uncheck the box to Allow other network users to control or disable the shared Internet connection.
Xbox 360 Offers The Last True Analog Hole? | 2019-04-20T16:49:52 | https://jakeludington.com/2006/12/08/xbox_network_co/ |
Do you have a new baby or grandchild? Are you wondering what that little bundle of joy is seeing through those beautiful eyes? At birth, infants are very light sensitive so you may notice that their pupils are quite small. They cannot focus clearly so highly contrasted images are optimal to enrich their visual environment. Their side or peripheral vision is better than their vision right in front of them.
By about a month of age, infants can begin to focus on objects 3 feet away. At 2 months, they should be able to focus even closer. By about 3 months, their distance vision continues to develop along with their eye muscle coordination. The result is that you will notice them following moving objects with their eyes. Their eye-hand coordination also improves at about this time also so you should notice them reaching for objects. By the time they reach 4 months of age, infants should be able to watch their parent’s smiling face move across a room. A babies’ color vision also slowly develops so around this time they should be able to respond to a full range of colors and shades.
One reason to be concerned about an infants’ visual development is if you notice that one eye consistently turns in or out. Another would be if there is a poor “red reflex” in one eye, for example when you take their picture with a bright light behind you. A third reason would be if one eyelid is consistently closed. Any of these findings should be brought to the attention of the child’s medical professional. Enjoy watching them grow and learn!
Dr. Martha Jay is a Board Certified Ophthalmologist (Eye Physician & Surgeon) at Madison Medical Eye Care with offices in Mequon & Saukville, Wisconsin. For more eye care information, call 262-241-1919 or visit www.MadisonMedicalEyeCare.com. | 2019-04-26T12:05:10 | http://www.lakeshorevision.com/cataracts-lasik-ilasik-blade-free-lasik-restor-len-implants-toric-implants-contact-lenses/visual-development-in-babies-by-dr-martha-jay-ophthalmologist-at-madison-medical-eye-care-with-offices-in-mequon-saukville-wisconsin/ |
The photo shoot took place at P.S. 33 in NYC. Featured are DonorsChoose.org board members and advisers Timothy Ferriss, author of The 4-Hour Workweek; Livia Stone and Biz Stone, Twitter co-founder; Alexis Ohanian, co-founder of Reddit; Charles Best, founder and C.E.O. of DonorsChoose.org; Stephen Colbert, host of The Colbert Report; Desirée Rogers, C.E.O. of Johnson Publishing; Anil Dash, blogger and founding partner of Activate; Theresia Gouw, partner at Accel; and myself. Though, somebody who feels I’m a celebrity may need to get out more often.
Yes, I’m repeating myself but I’m on the board for Donorschoose.org, and I’m currently giving $10k to match half the cost of projects with the keyword “military” if someone like you provides the remainder. If you’re able, please help make some matches with the Double Your Impact Offer.
You can read the whole Vanity Fair article here, and please remember to give to military projects via DonorsChoose if you’re able. | 2019-04-22T06:12:10 | https://craigconnects.org/2013/05/14/vanityfair/ |
Learn how to get really cheap clicks with Facebook ads. Use these cheap clicks to promote products with affiliate marketing. Follow up with building a list and email marketing.
Definitely not as easy as advertised, and does not provide enough training for a newbie to truly understand paid advertising techniques and email marketing.
The advertising video was very poorly done. Not only did the presenter spend most of his time telling you how much money he makes and not explaining the product itself, I felt the video and presentation was low quality and reflected poorly on the product.
It was clear that this was some kind of “loophole” system, and not a long term business plan.
As you will find out below, the “system” is not as easy as it sounds. If you are a beginner internet marketer or just getting started with PPC, do not be fooled by the promised of easy money!
Note: This review is based on a partial review of 1 Cent FB Clicks. They have not provided me with a username and password after paying for their product, and I'm currently waiting for support to respond.
Facebook advertising is definitely a way to make money online. In fact, I have made some money promoting a product via Facebook ads. If you are not familiar with PPC, the way it works is that you pay a certain amount of money for each click you get from advertising. Prices range from pennies to dollars, depending on the words you target.
Getting $0.01 cent clicks would be very, very helpful to creating decent profits online.
The video presenter speaks about “high quality traffic“, which is very important. Many “make money” products say that you can get thousands of visit per day, but they are either robots, or people paid to click. This doesn't convert to sales. Getting high quality traffic is essential to making sales, because you want to the people that click your ads to actually be interested in what you are selling.
If you look at the screenshot of some of the offers that their top sellers are promoting, these are extremely spammy and scammy offers.
These are NOT valuable things you want to promote!
In fact, I've reviewed some of these products or know people that have reviewed them. They are not products you want to promote to people because they simply DO NOT work. You, of course, have the choice of which products to promote, but it should be known that these “high earning” 1 Cent FB Click users are promoting work at home scams and make money products. These are often banned by FB, or at least have tough restrictions placed on them.
What this means is that 1 Cent FB Clicks is definitely exploiting some loopholes in the FB advertising system, and we don't know how long these “tricks” will last.
The owner of 1 Cent FB Clicks also fails to mention that you will have to pay an extra fee for an autoresponder. In the first instructional video, it's mentioned that you direct people to your Facebook Fan Page, not an external website. This is one way to get cheap clicks! Great, but then you need them to sign up for your email course or special offer.
Don't have one? Oh, he forgot to mention that you need to create or buy one.
Then they sign up and you can send them more offers via your autoresponder.
Don't have one? Oh, he forgot to mention that you need to pay $20 per month for this thing. Don't know what it is? Oh, he forgot to tell you that part of his plan is to do email marketing. If you don't know how to create an effective email marketing campaign, you are going to be LOST.
So, we now know that other than some tricks for finding cheaper click prices on Facebook, 1 Cent FB Clicks is only about driving traffic to an email marketing list. This is where the real work is done. Email marketing is tough, and you will likely need to purchase another product to learn how to do it right. This product is NOT as simple as getting people to click your ad, then making money.
These are NOT standard results!
One last thing that I absolutely hate about these types of products is that they distort reality and make you think that making money will be fast and easy. They tell you that you can make $500 within the first 5 hours, or $1200+ dollars on your first day of using their system. Then they pull tricks like when Jani says that his coaching is 100% free, but you need to pay a small fee to enter their Facebook group.
The “small fee” is $147 dollars – 3x more expensive than the product you just bought.
If you have a budget to pay for advertising and want to learn about Facebook Ads and how to get cheap clicks, you could probably benefit from some of the information contained in this course.
Including all the unrealistic promises of profit, the misleading impression that you will start generating income quickly, and the general premise of how 1 Cent FB Clicks works, I cannot recommend this product. There are some good points to it, and could potentially work for some people, but it is clearly not designed for newbies.
There are many flaws with this product, namely it's lack of transparency and the fact that it's not really a long term business plan. What I teach on One More Cup of Coffee is how to start a website about a topic you are interested in. By owning your own site and promoting products and services you can honestly recommend, you can create a real online business to increase or replace your current income.
I learned to make websites from an online business community where there is no hype, no shady sales tactics, and a community of honest people looking to help each other out. No wonder it's currently the only place I recommend to newbies trying to learn how to make money on the internet.
Nathaniell,thank you very much for your review. Before seen your review I was thinking about to buy the 1 cent fb clicks product but now I wouldn’t.
Happy to help man. Hope you find a product that suits your needs.
I would like to start a online business with WA.
You can join through the links on my Wealthy Affiliate review. Don’t forget to send me a message inside the community!
Yes, i have tried ClickSure several times in the past and I can tell you, it is all JUNK.
I have been able to get refunds for all that JUNK.
Bank of america will not have that crap.
Good job Lesli. I can’t believe Clicksure is still allowed to operate with all the junk they peddle over there.
Nathaniell, buddy you are saving the money and time of tons of people out there with reviews like this.. keep up the good job man!..
I purchased this product but didn’t receive any download product or anything else.
My bank statement shows I have been debited, there is no after sales support.
I would contact their support team or perhaps ClickSure to try to get access or a refund.
Excellent review .. Thank you!
Phuleeeeeze Josh. Everything on Clicksure is junk. This one had issues getting the product (another issue worth mentioning) and it wasn’t worth my time following up on it. But I have tried other stuff like Instant Traffic Commissions and Commission Uprising. I could argue with you all day about how this stuff isn’t worth YOUR money, or how this is MY blog and I review products as I please, but I have a business to run.
Thanks for this man! I personally use FB ads a lot and if I came across this I would consider going for it to “test it out”.
Thanks to you I can save my money and re-invest in FB ads LOL!
I will definitely update once I get access to the real training tools. I hate to base reviews off of other reviews, but it’s been more than 24 hours and I still can’t access the product!
I’m glad you liked the review. Yes, that’s me that followed you in WA. It’s amazing how much you can access in Wealthy Affiliate for free, and the premium membership support is really unheard of in any other products.
I actually bought SBI today and am working on the review at the moment. I might email you a question or two! | 2019-04-24T00:05:52 | https://onemorecupof-coffee.com/1-cent-fb-clicks-review-hyped-and-misleading/ |
#725856 The link to the "Questions" section is called "Answers"
#990676 system-config-printer > error msg.
#990975 Alt+Tab change application, system hang-up!
#1007463 software manager lock up. | 2019-04-22T08:12:02 | https://bugs.launchpad.net/~oskar.wallgren/ |
I'm sure you know how much I love a new skincare product, and when a product is made specifically for dehydrated skin and has the words 'moisture bomb' in the title, it just becomes too hard to resist. I was in Boots the other day and I spotted 2 brand new products from Garnier; a day cream and a night cream. Obviously the name jumped out at me, but also the fact that I hadn't seen or read anything about them made me very curious indeed. The next thing I knew, they'd both tripped, fallen off the shelf and into my basket. It seems to happen to me a lot come to think of it!
As a day cream targeted at dry & dehydrated skintypes, It does the job pretty well. Is it the best I've ever tried? I'd say not, simply because I think it's slightly too light in texture. I'm thinking it will be great during the summer months, though.
I absolutely love how this makes my skin feel. It soaks straight in and leaves an almost velvet feel to the skin. I would definitely repurchase this as my night cream.
What's your favourite cream duo? | 2019-04-24T20:35:53 | http://www.itskt.com/2016/02/New-Garnier-Moisture-Bomb-Range.html |
The audio album and theatrical trailer of Superstar Krishna’s comeback film, Sri Sri, have been released by Krishna’s son and TFI’s current Superstar Mahesh Babu last night. Speaking on the occasion, Mahesh said that he is his father’s biggest fan.
Talking about Sri Sri, Mahesh said that he was quite excited when he saw his father’s getup in the film. Mahesh also lauded the film’s trailer and said that he is recollecting his childhood memories when he used to eagerly await his father’s film releases and that he is equally excited to watch Sri Sri soon.
Krishna, in his speech, thanked his first director Adurti Subbarao and producer Dhoondy for launching and making him a star. | 2019-04-18T22:36:58 | https://www.123telugu.com/mnews/i-am-my-dads-biggest-fan-mahesh-babu.html |
Africa is emerging as a lively battleground for global cloud providers.
PRESS RELEASE -- Huawei is preparing for a March launch for its cloud data services in Africa. The company is working with South African partners for the construction of the data centres in Johannesburg initially and later Cape Town. | 2019-04-25T04:00:52 | http://www.connectingafrica.com/cloud.asp |
Men's 8 Inch Steel Toe Waterproof Lace to Toe Logger. This rugged logging boot has an aggressive rubber outsole for dependable traction. Inside, your foot will stay dry due to a 100 percent waterproof membrane. Log on. | 2019-04-19T18:41:51 | https://www.carolinashoe.com/CA9825 |
Can’t find the user manual for your new Beyerdynamic? If you have lost or thrown out the CD with the Beyerdynamic manual and you need advice with settings, error messages or are just interested in the capabilities and different functions of your Beyerdynamic, then you can download a user manual from the Beyerdynamic website.
If the manufacturer’s website does not give instructions on where to download a Beyerdynamic user manual, then you will find plenty of Beyerdynamic fans in our database. Take a look at our discussion forum for your particular product, a more experienced Beyerdynamic user will surely be able to help you with the settings. | 2019-04-21T03:28:44 | https://www.pdf-manuals.com/beyerdynamic-344-brand |
Equity Real Estate is an ambitious property development company that specialises in acquiring off market property deals to then enhance value through planning gain and the construction of residential, commercial and mixed-use property for resale to the private and institutional investors. The management team have a unique blend of skills which include construction and development, corporate and structured finance and large scale infrastructure. The team have completed hundreds of projects of varying sizes over a period of 20 years and together form an experienced and dynamic team.
including apartments, duplexes and penthouses. The unit sizes vary from 80 to 250 square meters. | 2019-04-22T08:14:53 | http://greatcastle.org/equity/ |
What Are The Options Should You Have In The Configurable Wordpress Themes?
When you are looking for the website templates to create your website, one of the most important features that you look for is that of customization. You can always get the options such as the customizable Wordpress templates so that you can customize your website features as per your requirements. But what are features that you can actually customize when you are making use of such a template. Here are some of the options that you can have.
You may notice that there are various dashboard and homepage options available when you are getting the premium Wordpress themes. Here, you can customize the pages of the website as per your requirement. You may wish to change the homepage from time to time or according to the different events going on in the company or in the brand. Such templates offer you such feature of customizing the pages so that you can impress the customers in a much better way.
Apart from the pages, you can also customize the color scheme of the website. You just have to get the right HTML themes and you will be able to get the feature of selecting the right color schemes. You can change the color of the pages, the background and also the texts from time to time. It depends on you how you wish to make the site look and depending on that you can make changes in the color scheme of the site.
There are also a number of Wordpress themes that can offer you the option of selecting the right layout and format also from a varied number of options. You just need to select the right one from a range of options in order to customize the design of your website. One of the major needs for a website is to be simple and convenient for the audience. Hence, it is very much important that you have a proper layout so that the audience is comfortable with it. The layout may depend on a number of factors such as the color scheme, the features that you are using and also the content that you will be updating in the site.
There are a number of times when you may have to insert graphics and animations in the website. At times, you may have to customize the graphics so that you can have a perfect one for your website. The PSD template helps you in customizing the graphics so that you can conveniently do it all by yourself. Also, the PSD option has a number of other facilities also such as it makes your website responsive and also such that it can load much faster despite of the fact that the site has some high resolution graphics in it.
Having a configurable website is a great option if you are good at customization. You should have a clear picture that you wish to design and accordingly you can have a wide number of features and options that you can customize in order to make your website a great one. | 2019-04-21T11:03:22 | https://jthemes.com/products/tag/configurable/ |
Expansion of peer services would solve a lot of economic problems.
If there were more peer services, individuals with disabilities would not be as reliant on costly human service programs.
Relapse is less likely to happens because people know what to do when crisis strikes.
Peer services employment programs are designed to ease people off SSI.
Many people, when educated properly, won't even see it as a crisis.
Potentially individuals on SSI who become full-time peer workers would no longer need income from SSA.
More peers working would help to decrease stigma associated with disabilities.
If individuals have peer support services they are more likely to obtain and maintain employment.
Peer services make up for places where educators fall short.
With the reduction in stigma and the added support of peer services, employers may be more likely to hire individuals with disabilities.
With the guidance people get from peer services, they can make better decisions.
People will graduate with better function for more potential productivity.
People will be hooked up with housing upon graduation.
People will be hooked up with the community during the curriculum.
Shelter, food, water needs will be taken care of during detox & training.
ER & hospitals can be freed up for more severe disorders & injuries.
Education: Cooperation, respect, gratitude, team-work, effort, challenging oneself for recovery, available therapies (neuro-CPS), making lemonjuice from a lemon can be taught through experience.
Current medications will be continually improved upon. When people are on personal medicine & therapy, we'll be using biofeedback through close observation throughout the process.
We'll get it right the first time so as not to perpetuate the problem, overcrowding the facilities.
Less work-related injuries, thus keeping the company in business.
Employees won't be as sloppy.
Employees are more likely to show up to work on time.
Work routine is less likely to be interrupted.
Employees will make better decisions with sharper thinking.
Happy employees are productive employees, everyone is happier when well-rested.
The economy is less likely to fail when people can fully function.
Landlords running the hirise program will have the advertising advantage of offering a cooperative & effective sleeping environment specific to shift. Everyone needs sleep, it supplies a real demand.
Cost is minimal for a marketing advantage for the hirise program. The buildings already exist. Organizing them carries no cost. Eliminating the odors does though.
Peer support is a non-medical approach to the treatment of mental health. Trying too capitalize on mental issues would be a fraud and ends up violating the subject's well-being. Peer support complies with all do-no-harm principles of the Hippocratic paper Of the Epidemics. Peer support is more than being there for someone. It's like being a big brother or big sister, someone to help the friend think.
A peer specialist has already been through a DSM-diagnosed psychosis and has either overcome it via a holistic means, such as hypnosis, or uses an ongoing treatment with medication. However, the latter (medication), proves to be unstable in most cases because of the nature of the brain's reticular system. A once-and-done, usually taking several years, results in most stability. For example, a Navy seal Chief Petty officer Mikal Vega, 20 minutes into the documentary, has made it through a neck-break from an IED, fire-fights and more and that didn't kill him, but the psychiatrist almost did.
Conversations are rarely one-sided. They build self-esteem in the client as well as in the peer specialist because the client provides help as well as the specialist. In other words, the student is the teacher, and the teacher is the student. Both exchange ideas and help while exercising respect and responsibility, working together. The PS or CPS has been there, so experiences can be shared with understanding. This kind of therapy can transform the world view of the client into a new paradigm.
ER CPS: Sharing conversation with people at a hospital emergency room, sharing experiences and having conversation.
Peer Center Staff: works in a drop-in center or other similar organization.
Peer Navigator: peer support outreach to the homeless.
Peer Coach: works in ER to persuade people not to abuse the ER system.
Peer Bridger or Transition Coach: aids in transition well before and long after discharge from hospital or incarceration learn the public transportation system, help apply to job coaches, and integrate with society.
Psychiatric Residential Peer Support: advocates for fair treatment in the institution, run focus groups and acts as a transitional coach.
Youth Support Partner: works with people, usually young adults, to guide person towards life goals.
ACT Team and Outpatient Peer Support Specialists: advocates for human-centered recovery and fights against stigma. Does work that a Transition Coach does.
Peer Support Specialist: may support by appointment in an office or in the community. He/she provides resources and how to use them. He/she can facilitate recovery groups.
Peer Patient navigator: specialized to linking people to medical resources. Target clients are those with serious medical issues or miss appointments frequently.
Intentional Warm Line: CPS provides phone counseling.
Veteran Peer Specialist: Veteran sharing with another veteran his/her own mental health and coping experiences.
Peer-run respite programs: inpatient, lasting 7 to 30 days, is a powerful, intensive days-long help session for a client to work on recovery goals.
Attending a school on a subject you're interested in pursuing.
Volunteering at a local soup kitchen, homeless shelter, fire department, etc.
Physical activity gets the blood moving so everything within works effectively.
Avoidance of poverty promotes wellness. Having enough to pay for the basics and the occasional repairs encourages thriving.
Spiritual connection is a coping skill.
Community gregariousness because it takes a village to raise a child or to love the unlovable.
Relationship-building (participation in society) results in real progress leading to wellness and recovery.
Mark Salzer describes integrative health. This is exactly what we do at One Mind Restoration, we prepare you for goal-driven living, and that's what all Soteria-based programs are intended for. The first thing you must learn is how to challenge yourself daily for progress.
Raquel Gur, MD, PhD explains why laws must change to allow for holistic, humane (Soteria) principles.
Being there involves more than a phone call, and more than a trip to the office. Peer support can be adapted to involve family diplomacy and acting as a caretaker. It's more than talk. Talk is cheap. Peer support addresses all aspects of life, not just talk and not just drugs. Optionally, drugs aren't even necessary. A peer specialist can help with holistic care.
It's unique that people with more professionalism than most psychiatrists have concrete, proven, lived and experienced research to backup what they say and what treatments they suggest.
Peer support allows for a holistic method to battle, confront and embrace mental illness. We teach and train you what you need for wellness in your emotional, physical and spiritual life, and our activities allow you to enjoy life. Who wants to be addicted to drugs and play video games all day while causing oneself pain and tardive dyskinesia or diabetes, etc? A few hours a week of video games is beneficial to cognitive function, they don't always have negative influence. That isn't recovery. We avoid the profit machine and promote thriving instead.
The basic needs are food, water and shelter, and above that is safety and then love and belonging. What if those layers of Maslow's Triangle are fulfilled instead? What if adaptations are developed for the circumstances when those layers have been removed?
For user Endless Paradigms, he didn't start making progress until he used very strong herbs that addressed the adrenal system: home-brewed kombucha, ashwagandha, then mucuna pruriens and Resveratrol, then meditation. Herbs are powerful, Endless Paradigms suggests you try them, but they're not compatible with the meds offered by psychiatrists.
Immediately after I found that mucuna pruriens took my depression away, I started taking it daily, and the same with Resveratrol, which took away my panic attacks. I had been experimenting for years, many of which were dangerous, and I finally found a treatment. After a few years of mucuna and Resveratrol, I upgraded to meditation and prayer because I know that abusing any drug, no matter how holistic, creates a chemical imbalance. Therefore, every drug must be temporary.
Since there's no physical evidence for mental illness, no test can be done to diagnose it. This means it isn't physical. It may be the result of a brain injury, which is a more plausible explanation. Once we know the cause, we can work on a solution. One Mind Restoration works on the answer. The way of treating a physical injury is with physical therapy. A brain injury needs Oxygen and cognitive therapy. In the case of PTSD, for example, it has safer treatments than fatal medications, and they all effect vital functions. Some turn muscle into water. Others cause spasms called tardive dyskinesia. Others cause an itchy rash. About all of them cause alterations to thought or sleep.
If someone is suicidal, professionals in the old model have been conditioned to respond in a way that promotes more suicidal behavior. "They need drugs because they act out" or "It's better than the alternative." However, the statistics prove contrary to those sayings and reduce them to no more than delusional excuses. In nearly all cases, the psychiatrist is more delusional than the person subject to his or her treatment. Focusing on the problem only, without a solution, attracts more of the problem. We focus on the solution mostly, and not so much on the problem. The solution is coping skills, eating well, social connectedness and thriving.
At the 20-minute mark in the above video, Navy seal Chief Petty officer Mikal Vega, made it through a neck-break from an IED, fire-fights and more and that didn't kill him, but the psychiatrist almost did.
It's the mind that decides what to shoot and when, and it's the mind that decides how to carry it out. It's a process that's very specific and mission-critical. If that mind is altered in any way, the result will also be altered. It's a bit obvious, if you crack the seal on a CPU, allowing light and air into it, the entire computer might not function correctly. Even though you have a theory that the photoelectric effect from the light would "take the edge off," it's still going to put a bug in the system and it won't function correctly if at all. The computer is broken by mind-altering drugs, which damages all area of life because they're all based on the mind, or the CPU in our example.
If you are a psychiatrist, and feel responsible for all the lives you took, you don't have to be overwhelmed with the guilt if you stop and never do it again. There's still a future for you. Psychosis is very common among psychiatrists because of the guilt. There's an ancient practice called repentance. You can transform your business into a holistic practice. You can base your new business on principles and virtues from One Mind Restoration. You can repair yourself with the therapies offered or described by One Mind Restoration and associates and resources. You might want to hear from our star user Endless Paradigms, he has overcome mental illness and the peer-pressure of the psychiatric industry. Your college education isn't in the trash, but can be used in a less arrogant and more positive way, employed by your local health food store. It won't pay as much, but you will no longer be guilty of murder, and you'll have enlightenment in your heart. You are not hopeless, but a human being in a life-long school of learning, and this is one of the lessons. You can even learn to forgive yourself. The guilt can be overwhelming, and even drive people to commit crime.
There is plenty of room at the top, but no place to sit down. | 2019-04-21T08:58:19 | http://www.onemindrestoration.org/peer-save-life.php |
David Brewer, Confederation of UK Coal Producers (CoalPro) gave evidence on 15 Jun.
Jonson Cox, UK Coal Mining gave evidence on 15 Jun.
15. United Kingdom Parliament. Wednesday 15 Jun 2011 - Energy and Climate Change - Minutes of Evidence - UK Energy Supply: Security or Independence? | 2019-04-22T01:28:23 | http://whoslobbying.com/uk/coal_companies |
21/01/2013· Vertical Shaft Impactor (VSI) at the heart of the rotor! Duration: VSI Crusher Animation Duration: 6:09.
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Deep Rotor VSI Crusher. Deep Rotor VSI Crusher integrates many patents and three crushing methods, is a new and high efficiency crusher.
The first is vertical shaft impact crushing where rock is fed onto a table type rotor which accelerates and then discharges the rock at high tracked VSI crusher.
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Buy New REMco REMco VSI ROTORS for sale by Morgan Bennett Machinery Burleigh Heads. | 2019-04-23T05:02:05 | http://postcatcher.in/some-5589-VSI-crusher-rotor-kiat/ |
The high cost of long-term care has made planning a critically important issue for most middle-class seniors and their families. In fact, most seniors will likely require some form of long-term care. Sadly, many of them are unprepared for the significant financial burdens it places on their family’s hard earned savings. A family facing ongoing care at a rate of $10,000 or more per month can quickly exhaust their life savings. With proper planning, a senior's quality of life can be maintained even as care costs escalate.
While some seniors are able to afford private pay care, the cost of long-term care will consume the resources of all but the wealthiest families in a matter of years. Those who have planned ahead by purchasing long-term care insurance have a degree of certainty and peace of mind, knowing that they have a lesser need to rely on other sources in the future. Unfortunately, many can’t afford the high cost of long term care insurance or worse, because of age of medical condition cannot qualify for long term care insurance altogether. If you do have long-term care insurance, you should have clarity about what your policy covers. Many policies have high deductibles or provide for only a short period of care in facility. In fact, many who have long-term care insurance still have to resort to Medi-Cal to pay for their care.
The other option to pay for care is Medi-Cal. A joint federal-state program, Medi-Cal provides medical assistance to individuals, including those who are 65 or older, who meet certain income requirements, or who are disabled or blind. Medi-Cal is the single largest payer of nursing home bills in America and serves as the option of last resort for people who have no other way to finance their long-term care. Although Medi-Cal eligibility rules are implemented by each state individually, care must be taken to comply with federal minimum standards and guidelines.
While Medi-Cal eligibility with respect to long-term care was not difficult in the past, there has been a steady drift towards more complex and restrictive rules, the latest being the Deficit Reduction Act of 2005 which went into effect in 2006. California has been slow to implement these changes, and the law has resulted in complex eligibility requirements for those in need of Medi-Cal benefits. It’s no longer as easy as reviewing one’s bank statements. There are a myriad of regulations and we are in a period of change with regard to look-back periods, income caps, transfer penalties and waiting periods to plan around. In California, we can still plan using strategies that have not been available in many other states for years. People in the industry speculate that this will change very soon.
At Bay Laurel Law, P.C., we have the compassion and the expertise to help families prevent the financial strain associated with the high cost of long-term care. Contact us today at 650.525.0234 to start the process of understanding the issues surrounding Medi-Cal eligibility and to implement the planning and application process. | 2019-04-22T08:21:28 | https://baylaurellaw.com/lawyer/Quality-of-Life-Planning_cp3414.htm |
Copyright © 2013 Wenyi Zhang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Calpains are an important family of the Ca2+-dependent cysteine proteases which catalyze the limited proteolysis of many specific substrates. Calpains play crucial roles in basic physiological and pathological processes, and identification of the calpain cleavage sites may facilitate the understanding of the molecular mechanisms and biological function. But traditional experiment approaches to predict the sites are accurate, and are always labor-intensive and time-consuming. Thus, it is common to see that computational methods receive increasing attention due to their convenience and fast speed in recent years. In this study, we develop a new predictor based on the support vector machine (SVM) with the maximum relevance minimum redundancy (mRMR) method followed by incremental feature selection (IFS). And we concern the feature of physicochemical/biochemical properties, sequence conservation, residual disorder, secondary structure, and solvent accessibility to represent the calpain cleavage sites. Experimental results show that the performance of our predictor is better than several other state-of- the-art predictors, whose average prediction accuracy is 79.49%, sensitivity is 62.31%, and specificity is 88.12%. Since user-friendly and publicly accessible web servers represent the future direction for developing practically more useful predictors, here we have provided a web-server for the method presented in this paper.
Calpains are an important family of the -dependent cysteine proteases which catalyze the limited proteolysis of many specific substrates [1, 2]. Probably, 16 known calpain isoform genes are founded in humans. Then, 14 genes encoded proteins have cysteine protease domains, and the other 2 genes that encode some regulatory proteins are associated with some catalytic subunits forming heterodimeric proteases [3, 4]. Calpains play crucial roles in basic physiological and pathological processes, including the regulation of gene expression, signal transduction, cell death and apoptosis, remodeling cytoskeletal attachments during cell fusion or motility, and cell cycle progression [3–5]. Moreover, calpain aberrancies frequently lead to a variety of diseases and cancers . As we know, traditional experimental identification and characterization of calpain cleavage sites are labor-intensive and expensive. Recently, calpain cleavage sites prediction attracts more and more attention, and more and more studies have understood its regulatory roles and molecular mechanisms of calpain cleavage.
In recent years, many computational methods were developed to predict calpain cleavage sites. In the paper , Tompa et al. selected 49 calpain substrates with a total of 106 sequentially identified cleavage sites from the literature. They determined the amino acid preferences around the cleavage bond with 11-mer peptide, and they synthesized a short peptide of TPLKSPPPSPR to be a superior substrate of calpain. Then, Boyd et al. developed PoPS online tool to predict protease specificity [8, 9]. And the site prediction based on the frequency and substitution matrix scoring strategy predicted Calpain 1 and 2 specific cleavage sites . Recently, Liu et al. developed a new computational program for the prediction of calpain cleavage sites. With the previously released algorithm of GPS (Group-based Prediction System), they designed a novel software package of GPS-CCD (Calpain Cleavage Detector) for prediction of calpain cleavage sites . Although aforementioned predictors were effective, we should make more efforts to improve the performance of calpain cleavage sites prediction.
In this study, we developed a new predictor based on the support vector machine (SVM) with the maximum relevance minimum redundancy (mRMR) method followed by incremental feature selection (IFS). And we concerned the features of physicochemical/biochemical properties, sequence conservation, residual disorder, secondary structure, and solvent accessibility to represent the calpain cleavage sites. Experimental results showed that the performance of our predictor was better than several other state-of-the-art predictors, whose average prediction accuracy was 79.49%, sensitivity was 62.31%, and specificity was 88.12%. Since user-friendly and publicly accessible web servers represented the future direction for developing practically more useful predictors , here we have provided a web server for the method presented in this paper at http://202.198.129.219:8080/calpain_cleavage/.
Here, we selected 130 unique substrates for calpain cleavage sites. And all the proteins were extracted from Uniprot/Swiss-Prot (Jul 20, 2012), by searching the “calpain” in the field “Sequence annotation” with experimental verification. We defined a calpain cleavage peptide () as the cleavage bond flanked by residues upstream and residues downstream, where and were equal to 10. Similar to , all experimentally verified cleavage sites were regarded as positive samples, and the other noncleavage sites in the same substrates were taken as the negative samples. With the threshold of 40% identity by CD-HIT, the training dataset contained 368 positive samples.
The first feature we select is the position specific scoring matrix (PSSM) of each calpain cleavage peptide. All biological species have developed starting out from a very limited number of ancestral species. Their evolution involves changes of single residues, insertions and deletions of several residues , gene doubling, and gene fusion. With these changes accumulated for a long time, many similarities between initial and resultant amino acid sequences are gradually eliminated, but the corresponding proteins may still share some equal functions and action mechanisms. Accordingly, evolutionary conservation may play important roles in biological analysis . We used PSI-BLAST to generate the scoring of specific residues. PSSM profile for each peptide can be represented as a matrix of dimensions, and is the length of peptide; 20 dimensions mean a measure of residue conservation of 20 different standard amino acids .
The second feature we exploit is the feature of amino acid factors derived from AAIndex , which is a famous database including various physicochemical and biochemical properties. Due to native 20 amino acids having their own specific properties, the composition of these properties of different residues will affect the structure and function of the protein . Atchley et al. performed multivariate statistical analyses on AAIndex and replaced amino acid properties with five pattern scores (polarity, secondary structure, molecular volume, codon diversity, and electrostatic charge) . We use the five pattern scores to represent each amino acid.
We also consider other features to make full use of protein sequence and prior knowledge, including disorder score, secondary structure, and solvent accessibility. Therefore, the information of disorder score is involved with protein structure and function. In this study, we use VSL2 to calculate the disorder score of each amino acid peptide. Moreover, we use SSpro4 to predict the secondary structural property of each amino acid of a given protein sequence as “helix,” “stand,” or “other” which are encoded with “100,” “010,” and “001”. So, we construct a series of matrix, is the length of the chain peptide. The predictor SSpro4 also can predict solvent accessibility of each amino acid as “buried” or “exposed,” which is encoded with “10” and “01;” then, matrix is formed; is also the length of chain peptide.
As mentioned previously, for each amino acid of a given peptide, the following 31 features are needed: 20 PSSM conservation score features, 5 amino acid factors features, 1 disorder feature, 3 secondary structure features, and 2 solvent accessibility features. The length of given peptide is 21; there are total of 31 × 21 = 651 features. According to (6) of , the feature vector for any protein, peptide, or biological sequence is none but a general form of pseudo amino acid composition or PseAAC [21, 22] that can be formulated as where , is the transpose operator, and represents the feature.
We use the mRMR method to rank the importance of the 651 features based on minimal redundancy and maximal relevance . The ranked feature with the smaller index indicates that it has a better trade-off between the maximum relevance and minimum redundancy. The mutual information is used for reflecting the dependence of vector and vector : where and are two random vectors, is the joint probabilistic density, and and are the marginal probabilistic densities.
We can use the mRMR method to find the feature set , and each feature in has the index indicating its importance; the more important the feature is, the smaller the index is.
SVM belongs to the family of margin-based classifier and is very powerful to deal with prediction, classification, regression problems [24, 25]. Therefore, SVM is widely used for all kinds of problems. SVM looks for optimal hyperplane which maximizes the distance between the hyperplane and the nearest sample from each of the two classes. Formally, given a training vector and their class values , , SVM solves the following optimization problems: where is a normal vector perpendicular to the hyperplane and is slake variables for allowing misclassifications. Here (>0) is the penalty parameter which balances the trade-off between the margin and training error. In the work, LIBSVM package [26, 27] with radial basis kernel function is used. Two parameters, the regularization parameter and kernel width parameter , are optimized based on 5-fold cross validation using a grid search strategy.
In statistical prediction, three cross validation tests are often used to evaluate the performance of predictors: subsampling test, independent dataset test, and jackknife test [28, 29]. However, of the three test methods, the jackknife test is deemed the least arbitrary that can always yield a unique result for a given benchmark dataset as elaborated in and demonstrated by (28)–(30) in . Accordingly, the jackknife test has been increasingly and widely used by investigators to examine the quality of various predictors (see, e.g., [31–34]). However, to reduce the computational time, we adopted the 5-fold cross validation in this study as done by many investigators with SVM as the prediction engine.
5-fold cross validation is used in this work. The dataset is randomly divided into five equal sets, out of which four sets are used for training and the remaining one for testing. This procedure is repeated five times, and the final prediction result is the average accuracy of the five testing sets.
Four parameters, sensitivity (Sn), specificity (Sp), accuracy (Ac), and matthews’ correlation coefficient (MCC) are used to measure the performance of our model. They are defined by the following formulas: where TP, TN, FP, and FN are the number of true positive, true negative, false positive, and false negative, respectively. For a given dataset, all these values can be obtained from the decision function with fixed cutoff.
We can use SVM to predict the performances of each feature set and evaluate the set with the 5-fold cross validation; thus, the optimal feature set can be yielded [39–41].
In the Supporting Information S5, the mRMR feature table listed the ranked 651 features with the maximum relevance and minimum redundancy to the class of samples. The list of ranked feature was to be used in the following IFS procedure for the optimal feature set selection.
In IFS test (Support Information S5, see Supplementary Material available online at http://dx.doi.org/10.1155/2013/861269), we added the feature one by one and built about 651 predictors. In Figure 1, the MCC reached their maximum value when 284 features were used. The accuracy, sensitivity, specificity, and MCC were 0.7949, 0.6231, 0.8812, and 0.5249. Figure 1 showed the MCC plot based on Supporting Information S5.
Figure 1: Plot of the MCC of different number features.
In the IFS procedure, we selected 284 optimal features (Supporting Information S5). In the result, 154 belonged to the PSSM conservation score, 43 to the amino acid factors, 21 to the disorder, 63 to the secondary structure, and 3 to the solvent accessibility. It indicated that PSSM conservation score, amino acid factors and secondary structure played important roles to predict calpain cleavage sites. The optimal feature distribution revealed that site 1, site 7 to site 8, site 10, and site 12 to site 14 played the most important roles in prediction of calpain cleavage sites. Moreover, the features close to calpain cleavage site were more important than central site and the site far from the calpain cleavage site.
As mentioned previously, there were 154 PSSM conservation features, and we found that the conservation against mutations of the 20 amino acids had different impacts on the prediction of calpain cleavage sites. We measured the number of each kind of amino acids for the PSSM features (Figure 2(a)) and found that different mutations of amino acid had different roles in prediction of calpain cleavage sites. Mutation of the amino acid Valine (V), Leucine (L) and Phenylalanine (P) were important in predicting the calpain cleavage sites. In the mRMR feature list, the 2 to 5 ranked features were PSSM features at site 11, site 8, site 6, and site 4 against transition to amino acid Leucine (L). This indicated that the conservation of Valine, Leucine, and Phenylalanine were the keys to determining whether or not it was calpain cleavage site. We also measured the PSSM feature number of each amino acid site (Figure 2(b)). The result revealed that site 5, site 8, site 12, and site 13 were more important in predicting calpain cleavage sites than other sites (shown in Figure 2(b)).
Figure 2: Bar plots to show the distribution in the final optimal feature set for (a) the PSSM score and (b) the corresponding specific site score. It was shown from panel (a) that mutations of amino acid Valine (V) played most important role in prediction of calpain cleavage sites; followed by Leucine (L) and Phenylalanine (P). And it was shown from panel (b) that conservation in site 5, site 8, site 12, and site 13 was more important in determining the calpain cleavage sites.
We investigated the number of each type of amino acid factor features (Figure 3(a)) and the number of amino acid factors at each site (Figure 3(b)). As a result, the secondary structure was the most important features in predicting the calpain cleavage sites. And the codon diversity was the second important feature to predict calpain cleavage sites. In Figure 3(b), site 10, site 11, and site 21 had relatively more effects on the calpain cleavage sties. Moreover, in the Supporting Information S5, the first feature was the polarity feature, and the polarity feature at site 10, site 12, and site 15 played more roles in the calpain cleavage sites prediction. This indicated that the polarity of the residues located more close to the calpain cleavage site has a critical role in predicting the calpain cleavage site.
Figure 3: Bar plots to show the distribution in the final optimal feature set for (a) the amino acid factor features, and (b) the corresponding specific site score. It can be seen from panel (a) that the secondary structure and codon diversity were the most important one for predicting the calpain cleavage sites. It can be seen from panel (b) that the residues at site 10, site 11, and site 21 played more roles in the calpain cleavage sites prediction.
With the final optimal feature set, there were 63 secondary structure features; 21 disorder features and a reasonable explanation was that the feature of secondary structure and disorder encoding were sensitive for predicting calpain cleavage sites. And in the Supporting information S5, we could show that first index of secondary structure was 189 in site 1, and it was the “stand” feature; also the first index of disorder was 143 at site 1. There were 3 solvent accessibility features in the optimal feature set; they were in sites 1 and 2; however the index was 281, 282, and 284.
According to the mRMR and IFS procedure, the performance of predictor was the best when we selected 284 features. And the accuracy, specificity, sensitivity, Matthews’ correlation coefficient was 0.7949, 0.8812, 0.6231, and 0.5249. And we made a comparison with GPS 2.0, GPS 1.0, PoPS, site prediction 1, and site prediction 2. For MCC, our predictor was obviously improved than all other predictors. It indicated that our predictor has excellent performance in predicting positive samples. And in the same value of specificity (~0.90), our sensitivity was 0.6231, higher than the other predictor. But the accuracy of our predictor was slightly worse than those of the others. Since we did not know the ratio of positive and negative in their training set, we built the predictor based on a training set in which the negative samples were two times than positive samples. The sensitivity of our method was 0.6231, and the sensitivity GPS 2.0 was 0.6087, GPS1.0 was 0.5000, PoPS was 0.5245, site prediction 1 was 0.4130, and site prediction 2 was 0.3967, when the threshold was medium.
More importantly, the reasonably good performance of our method reflects that the physicochemical/biochemical properties can effectively capture the information of around calpain cleavage sites. But there still exists some limits in our method. For example, our predictor only considers the amino acid sequence information but does not consider the protein structure features. Therefore, in the future, we should focus on development of amino acid encoding schema and development of a predictor to maximize the prediction performance of calpain cleavage sites.
Calpains are an important family of the -dependent cysteine proteases which catalyze the limited proteolysis of many specific substrates. Calpains play crucial roles in basic physiological and pathological processes. In the paper, we developed a new predictor based on the support vector machine (SVM) with the maximum relevance minimum redundancy (mRMR) method followed by incremental feature selection (IFS). And we concerned the feature of physicochemical/biochemical properties, sequence conservation, residual disorder, secondary structure, and solvent accessibility to represent the calpain cleavage sites. And we selected 284 optimal features; these features were central to predict the calpain cleavage sites, and with the optimal features set, the accuracy of our predictor was 0.7949, and the sensitivity and MCC were especiallyhigher than other predictor. Further, remaining feature would contain more information of calpain cleavage and are needed more analysis in the feature.
The work is fully supported by the National Natural Science Foundation of China under Grant no. 60803102, Natural Science Foundation of Jilin Province under Grant nos. 201215006 and 201101004, Fundamental Research Funds for the Central Universities under Grant no. 11CXPY010, and Opening Fund of Top Key Discipline of Computer Software and Theory in Zhejiang Provincial Colleges at Zhejiang Normal University of China under Grant no. ZSDZZZZXK37. | 2019-04-20T15:08:03 | https://www.hindawi.com/journals/mpe/2013/861269/ |
Moira Furnace Museum Trust created a touring exhibition to mark the 100th anniversary of Gunther Plüschow’s escape from nearby Donington Hall. Gunther was the only German PoW in either World War to escape from Britain and get back home.
The Museum Trust’s Chairman Steve Scotney knew how he wanted to convey the dramatic story but asked for Quiet Storm’s help to make it happen. “When I met with Quiet Storm I had a detailed brief which included display stands, a movie and a brochure. I explained that the exhibition would travel to different size venues so flexibility was needed with the size of the display stands. We decided quite early on that we wanted a comic book style for the brochure and the film as the Museum Trust is keen to attract the interest of young people. | 2019-04-19T15:16:33 | https://www.quiet-storm.co.uk/results/2016/08/24/museum-trusts-showcase-exhibition-for-gunther-pluschow-s-historic-escape/ |
The Polish Heritage Alliance welcomes new members. Membership is open to people of all ages and backgrounds, whether you were born in Poland, have Polish ancestry or simply enjoy Polish traditions and culture. By becoming a member you will receive the quarterly newsletter and voting privileges at our membership meetings. Additional benefits are determined by level of membership.
To join the Polish Heritage Alliance, Inc.
Free use of Veterans Room for family functions for five hour period, once during the year, Sunday to Thursday, on first come basis under established conditions for facility use. | 2019-04-21T16:18:07 | https://www.polishcenterofwisconsin.org/membership1 |
Virginia: 2012 General Assembly Session Officially Convened Today!
The NRA Pursuing Continued Success During Iowaâ??s 2012 Legislative Session! | 2019-04-23T06:46:41 | http://www.szone.us/forumdisplay.php?s=572edd25424b9b7c31f342a0b20247db&f=81&order=desc&page=899 |
Anthony Hopkins was in Silence of the Lambs for only sixteen minutes. For that, he won the Academy Award for Best Actor and even more to the point—as you know—became one of the best movie villains ever. And yet, the level of sophistication concerning too many Godzilla reviews seems to find that not enough onscreen time indicates film failure. “Brevity is the soul of wit,” Hopkins needed just sixteen minutes, and for this summer blockbuster in May, Gareth Edwards’ Godzilla will leave you wanting more screen time in the way that you want orgasms to last longer.
Okay. It’s not that good, but hyperbole helps clarify that it’s already amazing; more would be better, but you’re already enjoying yourself. A lot. What’s not an exaggeration is that Godzilla, the character, succeeds because almost every other part of the film exceeds expectations in unexpected ways.
Beginning with the opening credit sequence, there’s, well, an opening credit sequence. When done right, they not only provide valuable information but help you transition from quotidian reality to this heightened state of expectation. Alexander Desplat wrote the score. I’m most familiar with his Julie & Julia, a score that’s perfect for a Nora Ephron film. Immediately, a comparison to John Williams comes to mind as, over and over, Desplat’s composing evokes the heavy orchestration and prominent use of the low brass section just as Williams’ did in Raiders of the Lost Ark. It does feel a little manic in a way that I can only describe as if a pinch Danny Elfman was thrown in. Like a dash of cayenne. Think opening credits for Men in Black. Williams’ work also includes Sabrina, a score just as delicate and lyrical as Desplat’s Julie & Julia, and something you should see if you haven’t.
Not as well known is the screenwriter, Max Borenstein. He’s a younger guy and hasn’t done too much yet. At the same time, he’s written a graphic novel prequel to Godzilla called Godzilla: Awakening. A delightful article drawing an important parallel in terms of Christopher Nolan’s realistic Joker to the realism of Godzilla can be found here.
This realism is crucial and bears itself out in the opening credits. From familiar images of sea monsters that look lifted from medieval maps to footage from the ’50s and ’60s of the military and nuclear bomb testing to this witty effect of redacting some of the credits, the film seamlessly makes its case. Right there. Opening credits. Specifically, that humanity has always known about these monsters of the deep, and these images on maps weren’t just creative thinking. Atomic testing made things worse. In a clever move, each line of credits comes up and then is redacted with that familiar swipe that we see on government documents. With music evoking Raiders of the Lost Ark, these first moments couldn’t come off any better.
Alas, not all is perfect in Godzilla. Bryan Cranston and Juliette Binoche play the parents of our main character, actor Aaron Taylor-Johnson. Given that much of the Godzilla story is supposed to be about the human element, it’s a sad irony that this is the film’s weakness. Cranston is always glorious, but his hair in the movie was shockingly distracting. I know I risk sounding shallow here, but I couldn’t believe it. I know what they were doing in trying to make him younger with the hair, but I swear, you can see it on Cranston’s face. He knows his fake hair looks terrible. Still, it’s Cranston, and he’s marvelous. I was thankful for each second of his presence on screen…except where it mattered most.
A better example would be a lesser movie, Armageddon. Bruce Willis hitting golf balls off the oil rig in the direction of the Greenpeace protesters was terrible but hilarious. And when he was describing his crew, Bear, played by Michael Clark Duncan (I still can’t believe he’s gone), Willis describes him as “Probably the only black man on a Big Dog in Kadoka, South Dakota,” as images of Duncan on a motorcycle, roaring down a gravel road, with police cars in chase, play on the screen. I was in South Dakota when watching this movie in the theater, and the entire theater exploded in praise at this scene. Admittedly, this is an extreme example, but I could go on. And you know what I’m talking about.
Instead, we get thirty seconds of a weirdly-haired Cranston and Binoche talking in a car and trying to be cute. But it was just awkward. In a bad way. It was almost as bad as Chrisotpher Nolan’s failure at making any of his female leads compelling in all his Batmans. I was so excited when Maggie Gyllenhaul was cast but devastated when she died. Not because she died, but because I didn’t care.
The bigger sin, however, was the casting for our main character, Aaron Taylor-Johnson. He looks the part, but he just doesn’t have the voice or acting chops for this kind of role. Thankfully, the film is so well made, the human element seems less and less important as you let yourself slip into where the film wants you to go.
While the scoring is great, the sounds of Godzilla are shockingly effective. NPR covered this nicely in “What’s In A Roar? Crafting Godzilla’s Iconic Sound.” Bravo to Ethan van der Ryn and Erik Aadahl as the sound design team for this. Just as arresting are the visual effects. Jim Rygiel heads special effects. He’s won three Oscars and is known for his work on the LOTR trilogy. I had difficulty finding information about the special effects, so here’s a cached article if you want to nerd out.
This is one of the best teaser trailers I’ve ever seen. And true to the movie, it makes you quake with just a shrouded image of Godzilla and that incredible roar. I was completely prepared to write this movie off until this trailer. But before the roar, before the shroud, there’s a hauntingly beautiful and terrifying scene of these soldiers parachuting out of the plane, red smoke lighting up trails as they free fall from black cloud to open, jaundiced sky, headed back into darkness. That wide shot, along with the music, will stay with me for a long time. And the film is full of these unexpected moments of haunting beauty.
There’s another scene where Elizabeth Olsen’s character sees a random parachute. All of the sudden, planes start dropping out of the sky like dead birds. That’s disturbing enough, but because we were distracted, just as Olsen’s character was, by the somewhat whimsical image of this white parachute resembling something used in the ’40s versus the more modern parachutes of today, we are even more disturbed. Another moment like this involved Taylor-Johnson. Twice.
There are two scenes where he’s in peril, and he puts on a mask. As soon as he does, all sound retreats except for his breathing. It’s such an elegant way to create suspense and arrest the attention. Artful, even. Director Gareth Edwards is a somewhat new director, but what happened under his helm seems to reflect a wisdom and command of storytelling that belies his credentials. This, along with the brilliant move on the part of the plot of making Godzilla into more of an uneasy hero, buoys this film into something that merits its box office spoils. I’m finding more reviews go into more detail about the plot, so I’ll not add to the mix. I will say, however, that just like I’m still uneasy about my affection for Hannibal Lector, I felt this same unease with Godzilla. But more in that Joseph Campbell way and less the “Fff, fff, fff” fava beans and Chianti way. | 2019-04-26T03:58:20 | https://gozamos.com/2014/05/movie-review-godzilla/ |
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2. Avoid multi-vitamins. Grabbing a multi-vitamin straight from the pharmaceutical shelf is a common tactic.
4. Flavor foods with herbs and spices.
5. Eat something new each week.
6. Try some raw meals.
7. Reduce intake of refined sugar.
Even if you’re just trying to adopt a more plant-based diet for better health, these tips are a great way to get started. | 2019-04-26T13:06:54 | http://rawandwell.com/tips-to-switching-to-a-vegan-lifestyle/ |
This is a placeholder page for Dennis Archer, which means this person is not currently on this site. We do suggest using the tools below to find Dennis Archer.
You are visiting the placeholder page for Dennis Archer. This page is here because someone used our placeholder utility to look for Dennis Archer. We created this page automatically in hopes Dennis Archer would find it. If you are not Dennis Archer, but are an alumni of Cambridge Springs High School, register on this site for free now. | 2019-04-21T16:39:46 | http://cambridgespringshighschool.com/alumni/3550351/dennis-archer.html |
Heating 1 Tbs oil in a small sauce pan over medium high heat. Add garlic, shallot or onion, stir until fragrant. Add vinegar, lemon or lime juice, soy sauce, honey, and thyme. Mix well, taste and adjust season if needed to your liking. Set aside.
In a large saute pan, heat 2 Tbs oil over medium high heat. Put chicken skin side down, lightly season with salt and pepper, fry until golden brown, turn over about 2-3 minutes each side. Pour the sauce over, simmer about 10 minutes. Turn occasionally for the sauce coat chicken pieces even. Serve with rice, or bread. Do not forget your veggie.
You can broil chicken in a toast broiler after lightly seasoning with salt, pepper, oil, a few slices of lemon or lime, and sprinkle with thyme for total 15 minutes. Then mix with sauce.
Left over thyme freeze well in its own container.
You can fry chicken first and after chicken is golden brown both side. Move the chicken to the edge of the pan and add garlic and shallot to the center of the pan. Then add the remaining ingredients, bring it to a boil. Then turn and coat chicken with sauce until the chicken cooked through. | 2019-04-23T10:52:46 | http://japantalk.info/vietnam-food/pan-seared-chicken-with-sticky-lemon-sauce-ga-chien-with-nuoc-sot-chanh.html |
3 April, 2018: The Women’s International Match Racing Series today announced the 2018 series schedule with events in Finland, Sweden, Russia and the US Virgin Islands. This year marks the sixth consecutive season of the WIM Series, the world’s first and only women’s professional sailing series founded in 2012.
Up to 30 of the top women’s match racing teams will battle for the coveted series trophy starting in Helsinki (Finland) 25-29 June followed by back-to-back events in Lysekil (Sweden) 6-11 August, and Ekaterinburg (Russia) 13-18 August. The Series finale will be staged in the turquoise waters of St.Thomas in the US Virgin Islands 29 November – 2 December. A penultimate fifth event is expected to be added to the schedule in September and the Series is keen to also add a US event.
British skipper Lucy Macgregor (GBR) and her team won both WIM Series events that they entered last year, one being the World Championship in Helsinki.
Anna Östling and her Team Anna have been ranked as the number one female match racing team in the world since August 2016, and they are looking forward to entering the new season.
The WIM Series is looking at adding events to the 2018 calendar. And, as the only international professional sailing series for women, the Series aims to inspire both female and male sailors all over the world.
In addition to competing at different venues on the WIM Series, teams will also be tested with sailing different boats at each event, one of the unique elements of the match racing series. The yachts, usually 20-30ft in length and designed for 5 crew, are supplied by each event. The class of boats will range from the J80’s in Helsinki, to the Far East 28’s in Sweden, Ricochet 747’s in Russia, and the classic IC24’s in St Thomas. | 2019-04-19T15:15:40 | http://www.wimseries.com/wim-series-announces-2018-series/ |
In 2017, natural gas escaping from a severed pipeline was blamed for an explosion that destroyed a house in Frederick, about 30 miles (50 kilometers) north of Denver.
Cell Phone #, Address, Pics & More. Frederick Means's Info - Look Free!
Frederick Means's Past Available Online. Simply Search a Name and State.
Get Frederick Means's Phone, Email, Social Profiles. No Hit – No Fee!
Frederick Means: Current Address, Age, Phone, Email & More. Get Your Report Now. | 2019-04-20T17:05:29 | https://finance.search.yahoo.com/search?p=Frederick%20Means |
Specializing in residential and commercial air conditioning installation, Mack Heating & Cooling is dedicated to keeping clients in Columbia, SC nice and cool. No job is too big or small, and we aim to deliver complete customer satisfaction on every project we undertake. We also offer a wide selection of air conditioner models at affordable prices to meet your specific needs.
Specializing in residential and commercial air conditioning repair, Mack Heating & Cooling is committed to keeping clients in Columbia, SC cool. No matter how old your system is, we'll work our hardest to repair it in a quick and cost-effective fashion.
Is your air conditioner on its way out? Does it seem to be working less efficiently than usual? Air conditioning units and central air systems only last so long, so if you're in need of air conditioning replacement in Columbia, SC, turn to Mack Heating & Cooling to get the job done.
A properly functioning air conditioning system is something that every office building or commercial space needs. If your building's air conditioning system seems to be on the fritz, you need prompt, reliable commercial air conditioning service from a trusted team. In Columbia, SC, the company to call is Mack Heating & Cooling.
Aside from poor performance and high energy costs, many potential dangers can result from improper water heater installation. That's why choosing the right plumber can make all the difference. If you need a new water heater in Columbia, SC, turn to Mack Heating & Cooling to handle the job from start to finish.
Use a Columbia South Carolina HVAC contractor to save money on energy bills, look at your system, and make sure that it's running efficiently. At Mack Heating & Cooling we will present you with the right parts to keep your system functioning properly and have an approved written estimate that shows how competitive our prices are within the industry.
At Mack Heating & Cooling we have the knowledge needed to ensure prompt project completion times. Our goal is to be the Columbia South Carolina HVAC contractors you turn to for any heating and cooling issues. Call our office today to learn more about our team and prices! | 2019-04-24T00:29:17 | https://www.hvacsystemscolumbia.com/ |
The larva of the species Glyptotendipes (Caulochironomus) nagorskayae is described. In Moller Pillot et al. (2000) the species is named Glyptotendipes (Caulochironomus) spec. Belarus.
The feeding on freshwater invertebrates was studied. The results show that there is a great impact on the number of invertebrates in waterbodies where Gammaridae occur. The impact is greatest when collected material is transported in buckets.
The male imago, pupal exuviae and larva are described. The larvae of five species, four belonging to the Chironomus luridus agg. and one belonging to the subgenus Lobochironomus, can be identified using a provisional key. | 2019-04-21T16:51:31 | http://library.wur.nl/WebQuery/groenekennis?achternaam==Vallenduuk |
Kelly Rowland and Paulina Rubio have joined The X Factor, replacing the outgoing Britney Spears and L.A. Reid on the Fox reality show’s judges’ panel. The two will round out the panel with series creator Simon Cowell and returning judge Demi Lovato, according to Reuters. Rowland, now a solo artist, is no X Factor novice – she served as a judge on the British version’s eighth season in 2011.
The X Factor has been unsteady since its 2011 U.S. premiere: viewership fell from an average 12.5 million per episode that year to 9.7 million per episode. Cowell has swapped out judges each season, flipping Paula Abdul and Nicole Scherzinger for Spears and Lovato in Season Two. The U.K. X Factor, however, has found success with breakthrough artists including Leona Lewis and One Direction since launching in 2004.
The X Factor kicks off auditions today in Charleston, South Carolina, with tryouts running through July. Its third season begins this fall on Fox. | 2019-04-24T20:00:34 | https://www.rollingstone.com/music/music-news/kelly-rowland-paulina-rubio-join-x-factor-as-judges-94283/ |
It’s so much fun to play a baddie…. especially as a woman! I’m delighted to share a few behind the scenes snaps of me getting into character to play an evil commander in bold scifi thriller “The Electric Dream”! | 2019-04-24T12:21:23 | http://www.juliaeffertz.com/news-1/2019/4/1/on-set-shooting-for-international-scifi-thriller-the-electric-dream |
The owner of a metal parts manufacturer is looking for a buyer to take over the business. The owner wants to pass the ownership of his company to another party, as he is tired and wants to leave in the next few years. The owner does not have a general manager, so the new owner would be involved in direct management of the company, or he will be forced to find a suitable manager.
The company owns surface of approx. 20ths. m2, divided into four production units. The company owns a modern machinery and uses the most advanced software. In the recent past, the company has largely invested in new big cranes and milling machines.
The company employs 50+ people with expertise in metal construction, coordinated and guided by engineers specializing in machine building and equipment. A suited buyer could be one that needs these products as the demand is going up and there are only a few suppliers left in Europe, most of which are in China.
Feel free to contact us for more information regarding this metal parts manufacturing company for sale in Romania. If this metal manufacturer for sale does not fit your requirements feel free to ask for other manufacturing companies for sale. If you are interested in buyers of manufacturing companies, please visit the section manufacturing companies wanted. | 2019-04-24T00:16:27 | https://www.corporatefinanceineurope.eu/business-sale/metallic-parts-manufacturer-romania-for-sale.htm |
Abbington Village is the first web site I built in 1995. My idea was to build a site with travel related information about the New England states, where to stay, what to do, etc. The name Abbington Village sounded new englandish and I spelled it Abbington because search engines at that time listed results alphabetically. Micha Archer did a fantastic drawing of Abbington Village based on my description of the types of places you would find in the village - a Visitors Center, an antigue store, the General Store, a Crafts Fair on the Town Common, etc.
In the beginning the site drew a lot of visitors, but over time, many other sites were built offering similar information and the traffic dwindled. So now, I've decided to have just a couple of pages with a few pictures and some general info.
Listed below are just a few of the wide variety of four season travel, sightseeing and vacation activities available in New England.
The Fall foliage viewing season attracts visitors from around the world.
Skiing, snowboarding and skimobiling are just a few of the outdoor activities to be enjoyed during the Winter season.
Spring, Summer and Fall - play some of New England's scenic and challenging golf courses.
Any season is a good time to spend a romantic weekend in a bed and breakfast.
Walk the beaches of Cape Cod or take the ferry to Martha's Vineyard or Nantucket.
Trace our nation's history from Plymouth Rock to Boston's Old North Church to the battlefields of Concord and Lexington.
Cruise on a windjammer in Downeast Maine.
Hike the Appalachian Trail through Connecticut, Massachusetts, Vermont, New Hampshire and Maine.
Whitewater raft down Maine's Kennebec River.
Fly fish the famous Batten Kill River in Vermont.
Drive or take the historic Cog Railway to the top of Mt. Washington.
Tour the Gilded Age summer "cottages" of the turn of the century's wealthiest in Newport.
Visit the Norman Rockwell Museum and the Basketball Hall of Fame.
Take in a Red Sox game at Fenway Park.
Shop around the clock at L.L. Bean.
Crack open a lobster or try some clam chowder.
Hunt for antique and collectible treasures in Brimfield.
Take the kids to the beach, a museum, or an amusement park.
Check out My Favorite Places for more suggestions.
Be Happy, Be Yourself, Be Bold.
Abbington Village is a trademark of The Abbington Group.
© The Abbington Group 1995-2018 All rights reserved. | 2019-04-25T08:44:34 | http://abbington.com/ |
Log in to learn more about junaidfromnull, share content, and exchange messages and invites. Not a member? Join Now! | 2019-04-20T06:52:13 | https://forums.developer.apple.com/people/junaidfromnull/places |
Pica Design Ottawa – Creative. Experience. Dedicated.
Welcome to the on-line portfolio of J.Frenken – a work in progress. I have finally learned some WordPress so I can actually get the site looking as good as my regular design work!
As an introduction, here are some samples of my design, illustration and photography.
Photography – Little Berries in my yard.
Who is Pica Design Ottawa?
J.Frenken – Graphic designer, layout artist, photoshop magician, technical illustrator, photographer.
Please contact me if you think I might be a good fit with your company or project. | 2019-04-21T18:32:57 | http://www.picadesignottawa.com/ |
In this episode, I sit down with Mike Fallat, owner of Dream Starters University. Mike and his team helps entrepreneurs, business professionals, and trainers write a best selling book within 30 days. Mike walks you through the entire process and how he can produce such a high quality book in such a short time. This is a must listen if you're looking to get more exposure, build more credibility, attract more leads and grow your business.
My guest this episode is Marilyn Rodriguez. Marilyn is a Feminine Grace Mastery Coach specializing in guiding women to connect with the Soul of their Femininity. She is a #1 Amazon International Best Selling Author, Inspirational Speaker and Women’s Alignment Coach. Marilyn combines her dynamic energy with her soothing soul style to inspire her clients and audience to create deep transformation and discover their true power within. | 2019-04-26T03:47:47 | https://tunein.com/podcasts/Education-Podcasts/PK-Experience-p1187445/ |
Entries are due in by January 7th, 2011 (midnight, GMT), and the community will vote on the winners. We split the voting up into 2 rounds, with the first round starting on January 12th, 2011. The winners will eventually be announced on January 28th, 2011.
Second Place (Approximate** Value: $750): An MH-C801D Eight Cell 1-Hr Charger and two 2400mAh 4-Pack AA IMEDION "Ready When You Are!" Rechargeable Batteries courtesy of Powerex by Maha Energy, A 1-year Pro Account courtesy of SmugMug, An Urban Disguise® 70 Pro camera bag courtesy of ThinkTankPhoto, The 123di Interactive Learning Suite - Extended, Boxed courtesy of 123di, A Lifetime, Level II Premiere Membership, 10 PhotographyCorner Pens, and a 2011 Corner Calendar courtesy of PhotographyCorner.
Honorable Mentions - Sixth to Tenth Place (Approximate** Value: $500): An MH-C204W 1-Hour Worldwide Travel Conditioning Charger and a 2400mAh 4-Pack AA IMEDION "Ready When You Are!" Rechargeable Batteries courtesy of Powerex by Maha Energy, A 1-year Power Account courtesy of SmugMug, An Urban Disguise® 70 Pro camera bag courtesy of ThinkTankPhoto, The 123di Interactive Learning Suite - Extended, Boxed courtesy of 123di, A Lifetime, Level I Premiere Membership, 5 PhotographyCorner Pens, and a 2011 Corner Calendar courtesy of PhotographyCorner. ELIGIBILITY: Worldwide Not eligible to enter? - Find contest where you are.
COPYRIGHT: Copyright of the submitted photographs remain with the photographer. USAGE RIGHTS: Photographs can be displayed in the Contest Corner Photo Galleries, and throughout PhotographyCorner.com during and after the duration of the contest. All other rights remain with the photographer. | 2019-04-18T16:25:49 | https://www.photocontestinsider.com/photographycorner-com-2010-photograph-of-the-year/ |
Get your fire started without the paraffin.
Made from wood shavings, spun in to wood rope and dipped in wax, our firelighters are 100% natural and burn for an average of 5-8 minutes.
Only 1 firelighter is required for each fire, and we recommend using them with a handful of kindling.
There are 50 firelighters in each pack.
Our packs of 50 Natural Firelighters can only be purchased with a firewood order. | 2019-04-24T06:27:37 | https://www.logsforsale.co.uk/firelighters/ |
There's a reason why homeowner's and small business owners are turning to XRefer when they need fast, fair priced dumpster rentals in Arlington, VA. Whether you just need a cheap 10 yard dumpster for a day or two, or you need a long term rental of a few 40 yard roll off dumpsters at a Arlington construction site, XRefer has the solutions that you've been looking for. Our customers in Arlington have the benefit of tapping into XRefer's network, which allows them to choose any size dumpster, while also only working with the most reliable, affordable local haulers. When you rent a dumpster in Arlington with XRefer, you can rest easy knowing that we've researched the market and that your experience will be fast, easy and affordable, without the hidden fees or hassles that often come along when renting a dumpster in Arlington.
Serving: Arlington Ridge, Clarendon-Courthouse, North Rosslyn, Williamsburg and throughout Arlington.
Serving: Arlington Heights, Boulevard Manor, Fairlington-Shirlington, Leeway, Lyon Village, Maywood and throughout Arlington.
Serving: Arlington Ridge, Buckingham, Forest Glen, Glebewood, Gulf Branch, Long Branch Creek and throughout Arlington.
Serving: Arlington Ridge, Barcroft, Bellevue Forest, Colonial Village, Highland Park-Overlee Knolls, Stafford Albemarle Glebe and throughout Arlington.
Serving: Buckingham, Douglas Park, Glebewood, Penrose, Tara-Leeway Heights, Waverly Hills and throughout Arlington.
Serving: Alcova Heights, Bluemont, Buckingham, Rivercrest and throughout Arlington.
Serving: Bellevue Forest, Cherrydale, Glebewood, Lyon Village, North Rosslyn, Old Diminion and throughout Arlington.
Serving: Alcova Heights, Columbia Heights West, Nauck, Williamsburg and throughout Arlington.
Serving: Ashton Heights, Gulf Branch, Madison Manor, North Rosslyn and throughout Arlington.
Serving: Arlington Ridge, Ashton Heights, Cherrydale, Claremont and throughout Arlington.
Serving: Arlington Heights, Arlington-East Falls, Bellevue Forest, Cherrydale, Glebewood, Waverly Hills and throughout Arlington. | 2019-04-21T12:05:36 | https://www.xrefer.com/dumpster-rental/va/arlington.php |
Peter Darling is a queer, trans reimagining of Peter Pan.
Winner of the 2017 Rainbow Awards for Best Cover, Best Debut Transgender Book, ahd Best Transgender Sci-fi/Fantasy; Runner-Up for the 2017 Rainbow Award for Best Transgender Book.
“A thoroughly intelligent, ingenious take on Peter Pan, with a premise that shifts from delightful to funny to profoundly moving.” – KJ Charles, author of A Society of Gentlemen, Sins of the Cities, and more. | 2019-04-19T09:10:32 | https://austinchant.com/peterdarling/ |
Your driggs, ID O'Reilly Auto Parts store is one of over 5,000 O’Reilly Auto Parts stores throughout the U.S. We carry all the parts, tools and accessories you need, as well as offering free Store Services like battery testing, wiper blade & bulb installation, check engine light testing and more. Need help? Stop by and talk to one of our Parts Professionals today. | 2019-04-23T05:54:50 | https://locations.oreillyauto.com/id/driggs/autoparts-5592.html |
At Futureproofed, we believe that moving off fossil fuels will not only help avert catastrophic climate change and prepare for oil decline, but also bring about multiple societal and economic benefits. Founded in 2000, Futureproofed’s mission is to help business and local governments accelerate the transition to a desirable, attractive low-carbon economy in a practical and profitable way.
Monitor progress towards your carbon targets, tell your sustainable success story and inspire others. | 2019-04-22T21:31:29 | https://www.klipfolio.com/partner/futureproofed |
Find expert solar panel and wind turbine installers in Rotherham easily, with localtraders.com's free and simple service.
Harnessing energy from the sun and the wind are becoming extremely popular methods of powering homes across the country, and you could join the revolution today.
Whether you are looking at wind or solar power, or alternatively thinking about biomass heating systems, air or ground source heating pumps or upgrading to a combi-boiler in your home, you're in right place with localtraders.com.
Start saving money on your electricity and heating bills by filling out our enquiry form, or giving us a call, to receive up to six free quotations from highly skilled renewable energy installers in Rotherham, right now. | 2019-04-25T14:18:34 | http://www.localtraders.com/renewable-energy-generation-in-rotherham/ |
Thomas Aquinas was born of noble parents at Aquino in Italy, in 1226. At the age of nineteen he received the Dominican habit at Naples, where he was studying. Seized by his brothers on his way to Paris, he suffered a two years’ captivity in their castle of Rocca-Secca; but neither the caresses of his mother and sisters, nor the threats of his brothers, could shake him in his vocation. While St. Thomas was in confinement at Rocca-Secca, his brothers endeavoured to entrap him into sin, but the attempt only ended in the triumph of his purity. Having at length escaped, St. Thomas went to Cologne to study under Blessed Albert the Great, and after that to Paris, where for many years he taught philosophy and theology. The Feast Day of Saint Thomas Aquinas is March 7th. | 2019-04-22T22:40:29 | http://www.ololwit.org.uk/catholicity/our-school-saints/saint-thomas-aquinas |
Experimental and DFT Study on the Compounds [PdCl2L2] (L = 4-methylpyrazole, 4-iodopyrazole).
Inducibility of P450Coh by pyrazole and its derivatives.
Observations on the biochemical basis of ethanol metabolism by human macrophages.
Pyrazole binding in crystalline binary and ternary complexes with liver alcohol dehydrogenase.
Effect of pyrazole, 4-methylpyrazole, 4-bromopyrazole and 4-iodopyrazole on brain noradrenaline levels of mice and rats. | 2019-04-20T14:41:20 | https://www.semanticscholar.org/topic/4-iodopyrazole/423220 |
Less than two months after giving birth to her second child, Ciara has stepped on the scale to share her postpartum weight loss with fans. The 31-year-old took to social media on Tuesday to document losing eight pounds this past week.
Ciara said her weight loss goal for the week was 10 pounds, but is satisfied with going from 183 lbs. to 175 lbs. In addition to the latest weigh-in, Ciara also stated she lost 20 pounds during the first four weeks after giving birth to her daughter. The singer welcomed Sienna Princess on April 28 with husband Russell Wilson, but has yet to share any photos of the newborn.
In her new Instagram post, Ciara said she about ‘died’ this past week trying to lose more weight. However, Ciara then added she was about to go eat a cheeseburger and brownie after sharing her latest weight loss with fans.
Her followers complimented her honesty in how much work it takes to lose weight as they left comments on the post. Others stated Ciara should enjoy her cheeseburger as it was well-deserved.
Ciara also informed her 16.6 million Instagram followers that her goal is to lose another three or four pounds this coming week as well. It seems the new mom is keeping her weight loss goals realistic as she treats herself to a cheat day.
People magazine reported on Ciara’s initial weight loss as she claimed she gained 60 pounds while pregnant with her daughter. The “Goodies” performer may have surprised fans by sharing her current weight as some celebrities tend to be a bit more secretive when it comes to how much they’ve gained.
The article also stated Ciara gained the same amount while pregnant with her son, Future Zahir, whom she shares with rapper Future. While she’s been sharing her weight loss journey with fans, Ciara has been keeping a low profile when it comes to posting images of herself. Instead, she’s been busy sharing throwback photos from before becoming pregnant.
But her fans don’t seem to mind as they like and comment on her posts. Some of her followers seem to worry about Ciara giving up her music career now that she’s married to a professional football player and is a mother of two as they comment on her most recent posts.
Fans may not need to worry about Ciara retiring from the business just yet, though, as she is obviously working hard to get back into shape. Prior to her pregnancy, Cici flaunted a toned body as she showcased her dance skills in music videos and in social media posts.
It appears she’s dedicated to getting her figure back and is doing it her way as she celebrates the recent weight loss with a burger. | 2019-04-24T06:18:56 | https://www.inquisitr.com/4290831/ciara-shares-post-baby-weight-loss-with-fans-before-treating-herself-to-cheeseburger/ |
Dancehall star Mavado continues to show class teaming up with some of the biggest names in rap, and now Pop.One of Dancehall's finest has gotten close to Rihanna for a special collaboration.
Dancehall star Mavado continues to show class teaming up with some of the biggest names in rap, and now Pop.
One of Dancehall’s finest has gotten close to Rihanna for a special collaboration.
Earlier this month, Mavado posted a photo of himself with the Bajan beauty, and announced new music from the two.
“I have some serious work 4 my fans coming bigup @rihanna #jamaica #barbados #music #dancehall.” he tweeted.
The Jamaican native is signed to DJ Khaled’s, We The Best Label and is currently working on his third album.
There’s no other info on the collaboration, but considering that Riri’s working on her eighth studio album and Mavado usually features on tracks for other artists (including Iggy Azalea), we’re assuming that it’s intended for #R8.
This is the second time Mavado has shared this image, he first shared it late of last year. | 2019-04-24T08:09:53 | https://hypelifemagazine.com/celebritynews/mavado-rihanna-pop-dancehall-collaboration/ |
The 6th Annual Bridges Short Movie Festival will include a variety of juried and curated videos and short films. The program will include movies, videos and animations that have been created for educational, corporate and artistic purposes, and will provide another opportunity for you to experience innovative and integrative techniques in the fields of mathematics and art.
The animation ‘Katzengold’ will be part of the Bridges Short Movie Festival.
Using a single formula - a polynomial - the film shows fascinating transformations from a cube to a rhombic dodecahedron, to an octahedron and to a dodecahedron. It was created using the free software SURFER.
The authors will also give a short presentation at Bridges, exploring the connection of Pyrite, Plato and the mentioned Polynomial on July 31 at 2:45 pm, room 3, Baltimore University.
The paper is available at the IMAGINARY texts section. | 2019-04-26T12:26:36 | https://imaginary.org/event/katzengold-at-bridges-short-movie-festival |
It’s now four days since thingmonk and I’m still recovering. It’s the developer event for IoT in Europe and it really brings together a lot of people from the community. For two days that means “work hard, play hard”, with 25 or so speakers sharing their knowledge and opinions in short bursts of 20 minutes, with regular breaks for people to meet and socialise over splendid food, coffee and beer.
I must have emitted some 100 tweets from thingmonk and it’s nearly impossible to come up with a reasonable coherent summary of the event. I start with a personal perspective: I’m very community-minded and although IoT started out as a hobby for me, it’s become a job and I’m really glad I do it for both the money and the inspiration I’m getting from generally nice people – I’m not talking the business side of IoT, but the doers and makers who fight battles in the trenches of tech everyday. That includes thingmonk speakers as well as the audience. There was more than one “Oh, you’re THE $twitterhandle” during the conference.
Also, thingmonk is small enough so you actually get to speak to the presenters. We all know evil corporates that are now beginning to consume the IoT, but once you meet folks like Kyle Roche you see that even the dark tower that is Amazon AWS is just run by normal people.
While I’m writing this I realise: This is not going to turn into a summary of talks. Wait until the videos are going to come out, then you can hear Yodit Stanton, Matt Biddulph, Tom Raftery or even myself talk.
Thingmonk is all about the people.
Maybe the entire Internet of Things is, as probably best pitched by Joanna Montgomery who presented her heartbeat transmitting bed-ware Pillow Talk. | 2019-04-26T08:30:34 | https://badryan.github.io/2015/12/08/thingmonk-2015-conclusions.html |
Jumping out of your TV and into comics comes the hit Cartoon Network animated series "Batman: The Brave and the Bold". Featuring stories by TV series writer Matt Wayne ("Justice League", "Ben 10: Alien Force"), these tales team The Caped Crusader with DC heroes including Green Arrow, Plastic Man, Blue Beetle, Aquaman and many others. In the six thrilling issues included in this collection, Batman and his allies tangle with the Time Lord, saves the world's children from the Queen of Fables and, in a strange twist, Batman becomes President of the United States.
GMT+8, 2019-4-20 02:26 , Processed in 0.054885 second(s), 38 queries , Gzip On. | 2019-04-19T18:26:31 | https://www.byzhihuo.com/thread-27625-1-1.html |
Ioana Tomici is a designer and researcher born in Bucharest, RO. She is currently based in Rotterdam, NL where she graduated from Willem de Kooning Academy's Product Design department (Bachelor of Arts, 2013-2017).
present-day technological discourse. Her textual and visual work strives to analyse contemporary narratives surrounding social, political and economic progress based on the increasingly seamless transmutation of the digital into quotidian life. The results of her analysis frequently amount to the construction of fictional scenarios depicting potential (near-) futures.
A proposition for a mathematical model of the Earth that uses financial derivatives as a way to speculate on the future conditions of territories.
"[...] Such a financial model of the Earth with their correlating mathematical derivatives allows for a mapping of environmental conditions through the volatility surface. The volatility surface would then encompass both the current conditions of commodities reflected in the price, and the ones to come, reflected in the implied volatility. Collecting these volatility surfaces and mapping them on their respective position on the globe generates a model with which variables could be calculated to financially enhance these environments."
Video comissioned by Sami Hammana.
• a short film exploring how this technology would function and how it would become intrusive.
By creating a parallel between different types of omniscient entities — the regulatory and the mystical one — the act of surveillance is examined under its strive for accurate prediction. For the sake of speculation, these two seemingly distinct notions, mystical divination vs digital monitoring, should be bridged in order to better understand their respective implications; hopefully with the aim of identifying an intrusive phenomenon in relation to one which is remedial. Pansophic Encounters is a critical design tool in the form of a deck of tarot cards, used to perform a contradictory experience: extracting personal information by way of highly impersonal bureaucratic criteria, and contextualizing it for future therapeutic reference. Whether one’s data is being interpreted by forms of authority or by esoteric counselors should not be an issue; the only suggestion is that one should be given the choice. And that doesn’t seem to occur in the context of surveillance-states.
City Tour is a mixed media project, compiled as a visual essay containing fragments of Guy Debord’s Society of the Spectacle. The visual component of the project aims to present a simulated tour through Broadway NY, culminating with Times Square. As the semiotic makeup of the landscape progressively intensifies, the tourist is provided with commentary towards mass-media as an ideological tool for control within public space.
This is a project done in collaboration with Carmen Dusmet Carrasco. | 2019-04-19T18:13:56 | https://www.ioanatomici.com/ |
Greeting cards merry christmas is one images from 24 beautiful christmas pictures cards of Tierra Este photos gallery. This image has dimension 1024x768 Pixel and File Size 371 KB, you can click the image above to see the large or full size photo. Previous photo in the gallery is best christmas greeting card. For next photo in the gallery is funny christmas cards pics photos. You are viewing image #21 of 24, you can see the complete gallery at the bottom below. | 2019-04-23T10:58:18 | http://tierraeste.com/24-beautiful-christmas-pictures-cards/greeting-cards-merry-christmas/ |
Being within the performing arts industry, means that invariably your “interviews” are more likely to take place in the form of an audition. It renders normal CVs defunct and in its place you are often required to provide a one sheet document, specifically for the use of casting agencies and in some cases to leave at auditions.
In association with your CV, you may link your portfolio to it. The portfolio provides evidence of the work you have completed and will take its shape most commonly, online. If hardcopies would be required, these can be in the form of posters or reviews etc. The CV itself should contain concise details of your work in chronological order only.
Your CV must include a photograph, quite different to a normal CV where upon you are advised strongly against providing one. In an actor’s case, the photograph should be of much higher quality than a passport photo. It’s likely you already have a professional semi-side on picture you can use. Place this at the head of your document in black and white if you are going for acting roles or for presenting roles, it is more common to choose a full length colour shot.
Personal details are automatically included, information such as height, build, hair colour, eye colour, accents and whether you can sing. Habitually, having details of your agent on your CV is common place if you have one. Links to industry specific sites are also a bonus. If you sing, be sure to list your styles.
Education is largely irrelevant, so you can eliminate formal secondary examinations; however, it’s important to highlight any additional stage/professional training you may have received. Once you have this recorded it can be utilised in a skills section, that at a glance will showcase roles you would be suitable for.
The body of your CV should list your experience; it pays to group together roles that would be associated with film/TV/theatre. Listing them in chronological order with minimal details will be fine. The year, the title of the production, the part you played, the company and its director will suffice.
Once you are happy with the information you have included, made certain there are no grammatical or spelling errors, you now have, your industries form of a CV. Break a leg! | 2019-04-23T20:26:25 | https://www.thecvstore.net/blog/actor-actress-cv/ |
A business license is required for all businesses operating in the Town of Bethany Beach.
An application along with all required information must be submitted before a review and determination is made.
The licensing fee is due by the 1st of June each year, and the license is valid until May 31st of the following year.
§102-2. Annual license require; applicability.
No person shall engage in or carry on or aid or assist as employee, clerk or otherwise, in the Town of Bethany Beach, Delaware, any business, occupation or activity or use therefor any wagon, vehicle stand, store or other place or thing without first having paid the prescribed fee and taxes and having obtained from the Town of Bethany Beach an annual license for such business, occupation or activity. Specifically included are all persons, firms and corporations engaged for profit in selling any and all merchandise and/or given commodities and/or in providing facilities, services, rental units and/or food service within the Town limits. | 2019-04-23T14:16:59 | https://www.townofbethanybeach.com/345/Business-License-Process-and-Application |
Iaso Tea Review - Can it Help You Detox and Lose Weight?
Iaso Tea Review – Can it help you detox and lose weight?
Green tea is known to help with weight loss. However, many diet supplements with stimulants, even tea-based, can cause some pretty nasty side effects like rapid heart rate and dehydration. Also, if you have any cardiac, kidney, or bladder concerns you can’t use those products. This greatly limits users because many people who need help losing weight have diagnoses such as high blood pressure.
Also, not many people function well when they feel jittery. Total Life Changes has worked to create a product that doesn’t have stimulants, but still offers the health benefits you are looking for. But will it help you?
Total Life Changes offers a variety of products. They have a skin care line, coffees, and teas/supplements. This article will focus on the Iaso tea.
Iaso tea is meant to be a cleanse for your body. It is important to remember that your liver and kidneys are always cleansing your body, so you don’t need to take a product for that purpose. However, it seems that they use the word cleanse to try to describe what the product does do, which is about the closest thing you can get to a supplement induced “cleanse”.
The product only contains 9 ingredients: persimmon leaves, holy thistle, malva leaves, marsh mallow, blessed thistle, papaya leaves, myrrh, chamomile, and ginger.
Persimmon leaves have been shown to reduce stress and therefore blood pressure. It has virtually no side effects, unless you are one of the unlucky few who are allergic to it. This may not be a typical approach to weight loss, but stress plays a major role in weight gain.
When you are chronically stressed, the results are even worse because your body will start to grow fat around your abdominal organs (this is often seen in men when you can still see their ab muscles, but they are clearly larger). Not only is this fat more difficult to lose, it is much more deadly. So reducing your stress can be helpful for keeping you fit and healthy.
Holy thistle and blessed thistle are actually the same plant, although they may delineate because they use different parts of the plant. Regardless, they work the same way. This product is used for indigestion and bacterial infections. This may not seem to help your weight loss, but it may inadvertently do so.
Feeling sick or contracting an illness can definitely derail your diet and exercise regimen. It’s important to keep yourself as healthy as possible in general, too. After all, that’s what we are all chasing after. However, you cannot use this ingredient with antacids. It should be noted here that antacids that lower stomach pH will lead to increased stomach acidity, so although one Tums might help you for a moment, in the long run it doesn’t help your stomach. Holy thistle/blessed thistle can be a better alternative (or try ginger instead, which is consequently an ingredient in this tea).
Malva is an interesting ingredient because it shows some promising benefits, but it’s still being studied to assure that it actually provides these benefits. In some studies, malva has been shown to help with autoimmune disorders and chronic inflammation. It does this by stimulating white blood cells to work in a more effective manner. In one study it was even shown to have anticancer benefits.
Many of us actually have cancer cells in our body, but our immune system eliminates them and filters them out through our lymph system. So any product that may help with this process is good. Especially since malva hasn’t been found to have any side effects.
Marsh mallow is typically used for pain and inflammation. It is particularly effective in mucus membranes like those found in your respiratory tract and gastrointestinal tract, and it helps with urinary inflammation. This is interesting because it does the complete opposite of what most supplements do.
Caffeine is a major bladder irritant that can lead to urinary tract infects and potential inflammation of your gastrointestinal tract. By adding this ingredient, Total Life Changes are trying to create a product that solves the problems of other diet supplements. The only downside is that it may lower blood sugar, which can make this ta unsafe for those with diabetes. Also, it interacts with lithium, which is a medication for bipolar disorder.
Papaya leaves are another potential cancer-fighting ingredient. A study found that papaya leaves reduced inflammation, reduced tumor cell growth, and increased the immune’s system response to the tumor. The only downside is that some people are allergic to them. Otherwise, papaya leaves have not been shown to have side effects.
Myrrh is traditionally used for indigestion and to ward off typical ailments such as colds and flus. Again, this can still be helpful for your weight loss, particularly during winter months when these viruses are running rampant. However, it may cause you to experience some diarrhea and it can’t be used safely with blood thinners. Otherwise, it does not have any adverse side effects.
Chamomile is well-known for its calming effects. Again, lowering your stress can help you lose weight and keep you from gaining it. Not to mention, stress does other horrible things to your body anyway (makes you more susceptible to illness, decreases the quality of your sleep, etc.).
Ginger is often recommended for upset stomach. On your journey to health, you may be trying new foods. Many healthy foods such as fruits and veggies are often high in acid which can initially bother your stomach. The ginger in Iaso tea should help eliminate this barrier.
So even though no product will truly ever cleanse your body, Iaso tea can help boost your immune system so that it can respond effectively to attacks. It also helps to reduce inflammation while alleviating stress. So it may not be ridding your body of traditional toxins, it is eliminating many of the potential barriers to your success.
No matter how beneficial a product may be, it always comes down to convenience. Total Life Changes actually recommends making the product ahead of time because you can store it in the fridge. You simply make one gallon using two tea bags (you can use an empty milk jug to store it).
You’ll then drink one glass with lunch and one glass with dinner. You may also opt to drink ½ glass with your daily snack. Obviously, you’ll need to enjoy the taste to make this work. So you may want to buy the two tea bag trial pack first before investing more money.
Total Life Changes is a good company, and it is rare to say that. They do have distributors, which is a turn off for some users. But even with financial goals, their main focus is on helping others. Believe it or not, some companies do come right out and tell you it’s all about money- especially, if they are trying to recruit distributors. But it’s not only their words that demonstrate their commitment to their clients.
They fund their own research on their products. They readily share their nutrition labels and ingredients list. They also listen to the concerns of their users and make changes. For instance, they just upgraded to more eco-friendly packaging. Also, they make products that are focused on health. They are not trying to sell you unsafe quick fixes. In fact, they use ingredients to try to combat common complaints with similar products (e.g. soothing the bladder rather than irritating it). You really can’t ask more from a diet supplement company.
There are many different reviews for Iaso tea. We chose the one that had the most reviewers- 101 to be exact. The overall rating was 3.5 out of 5 stars. 48% of users gave the product a 5 out of 5 stars, 9% gave 4, 10% gave 3, 5% gave 2, and 28% gave 1 star. The main complaint of the 2- and 1-star reviewers was that they only received one tea bag when they had ordered two.
This is most likely an issue with the Amazon seller, so bypass this potential by going directly through Total Life Changes. Another complaint was the price. The two-bag trial is fairly expensive at ~$5 for two tea bags (1 gallon of tea). The price decreases rapidly when you buy it in bulk. For instance, a 1-month supple costs about $45. Considering what high quality teas costs, this is a bargain.
We give Iaso tea a 4.5 out of 5 stars. We reserve the last .5 because some users may experience allergic reactions to two of the ingredients (diarrhea). Also, people who have diabetes or are taking blood thinners should not take it. Otherwise, it is a great product. It may not be the quick weight loss fix that you are looking for, but it is a great product for your health.
Stress is a major barrier to weight loss and health, as is getting sick. Iaso tea tries to keep you in optimal health by limiting the barriers you’ll have to face in reaching your goals. It’s also convenient and doesn’t require a huge time commitment. Overall, if you’re looking to invest in your health, Iaso tea could be the product for you.
1. Amazon. (2016). Iaso tea-pack of 2 tea bags for 1 gallon.
Herbalife Formula 1 Review - Can It Help You Lose Weight? | 2019-04-19T17:06:55 | https://www.nutritioninspector.com/iaso-tea-review/ |
"We will not go (attend cabinet meetings) until a clear stand is announced on Telangana issue," Civil Supplies Minister J Krishna Rao told reporters here.
"We have told everything to our high command. We are hopeful that the Centre would come out with a positive response," IT Minister K Venkata Reddy said.
Asked how long the ministers would stay away from their official responsibilities, major Irrigation Minister P Laxmaiah said the ministers would resume duties whenever the Centre announced steps for the formation of separate Telangana.
"We wanted the Centre to give clarity on its statement by specifying a time frame for the formation of Telangana. We will act accordingly," he said.
The ministers had yesterday ruled out withdrawal of their resignations until the Congress high command comes out with a "categorical time frame" for the issue.
The ministers, who have sent a common resignation letter to Congress chief Sonia Gandhi, met Finance Minister Pranab Mukherjee, Urban Development Minister S Jaipal Reddy, Law Minister Veerapa Moily and party leader Ahmed Patel in New Delhi during the last two days and discussed the current situation and put forth their demands.
Meanwhile, the ministers and other senior Congress leaders had a meeting to discuss the current situation over the Telangana issue today.
"We will brief the leaders about the Delhi visit. We will discuss the issue threadbare," IT Minister K Venkata Reddy said. | 2019-04-25T12:37:36 | https://www.deccanherald.com/national/telangana-ministers-to-stay-away-from-cabinet-meet-41493.html |
The 1942 dime value is $1.25 - helped by the price of silver it contains. A majority of 1942 Mercury dimes, if circulated are at this price.
Collectors and dealers begin to attach a premium value to coins in "uncirculated" condition, coins that have remained well preserved and appear as if brand new. Pictured is a very nice example, with bright luster, few marks and a welcome addition to any Mercury dime collection. Value of this 1942 dime is $10 to $20 well above its $1.25 minimum silver value.
Dimes of 1942 also have an over date variety, it is seen in the date where the "2" is over a "1." Although a scarce coin, should you have one, it is easily detected when looking closely. A popular mint error with collectors and for you a possible valuable find. Compare your coins to the close-up image below.
These old silver dimes of the 1940's are always in demand, they introduce many to the hobby of coin collecting. Values can vary depending on the mint that struck the coin, but condition has the greatest influence on how much your 1942 dime is worth.
A mint marked 1942 dime is worth similar to the Philadelphia coin with the San Francisco dime at a slight premium.
Mintmarks are used to distinguish the minting facility that struck the coin. The San Francisco mint used an "S" mark and Denver a "D" both mintmarks are found on the reverse along the rim. Dimes without a mark were struck in Philadelphia.
A rare 1942 Mercury dime was created by the mint when preparing a die, the number "2" was punched over a "1" when the date was applied. Coins minted using this die show a clear 2 over 1 date. Few were released into circulation and when discovered collectors realized the scarcity and soon began the rise in value of the coin.
Pictured is an example with light even wear and in this condition sold at a David Lawrence Rare Coin Auction for $634. Many collectors of Mercury dimes consider the coin as part of a complete set, creating a solid demand. When an uncirculated 1942/41 enters the market values often reach over $1500.
The close up picture of the date shows the over punching of numerals is very clear. In the past many circulated long enough to wear considerably, leading to the possibility of finding one in any box of old coins. With the aid of a magnifying glass your 1942 dimes are worth a second look.
The chart shows the value of a 1942 dime the same covering grades "Good" through "Extremely Fine" condition. Collectors and dealers are always searching for the best quality, best preserved coins. They judge the condition of each and assign a "grade." Comparing your coins to the images finds the accurate condition value on the chart.
Uncirculated: This Mercury dime never circulated. Untouched since minted, it shines with luster. Your coin in this condition may show toning, but underneath there is no evidence of wear. Rotated under a light, an unbroken, radiating luster rolls across the surface. An uncirculated coin is one sparkling with a freshness placing it at the top of 1942 dime value.
Extremely Fine: Of interest to collectors are many Mercury dimes in Extremely Fine condition. The slight even wear leaves the majority of the design crisp and sharp. Liberty's hair above the eye is evidently worn but just slightly, wing details are beginning to show some smoothness. 1942 dimes in this condition will eventually be valued above their silver content.
Fine: Wear is noticeable covering the entire surface, diminishing the minor parts of the design. A blending of hair details on the obverse and a flattening of the design in the leaf details on the reverse. At this stage of wear your old coin still retains a pleasing look.
Good: Just beginning to merge into the lettering and date, the rim indicates the grade of this dime. The bust of Liberty is lacking all design features, no hair or wing elements are visible but she does remain well outlined. Holding 1942 dime value low is the fact collectors strive to add nicer examples to their collections.
Rare and valuable dates are scattered through out the series leading to a wide range in Mercury dime values. A key element, the condition of your coin, is a major driving force to rare coin values. Compare your coins to the grading images, determine their condition and check the value of your Mercury Head Dimes.
Coin Values Discovery... finds 1942 dime value and... all old US coin values. It is an excellent index with images and text links to all coin series, from Cents to Gold. Value charts, grading images with descriptions uncover how much your box of old coins is worth. | 2019-04-23T00:23:24 | https://www.coinstudy.com/1942-dime-value.html |
"CRB – Saone-et-Loire Fiber Optic Network Development – Bourgogne - Construction Project Profile" contains information on the scope of the project including project overview and location. The profile also details project ownership and funding, gives a full project description, as well as information on contracts, tendering and key project contacts.
The "CRB – Saone-et-Loire Fiber Optic Network Development – Bourgogne - Construction Project Profile" is part of Timetric's database of 82,000+ construction projects. Our database includes a 10+ year archive of completed projects, full coverage of all global projects with a value greater than $25 million and key contact details for project managers, owners, consultants, contractors and bidders.
Timetric's "CRB – Saone-et-Loire Fiber Optic Network Development – Bourgogne - Construction Project Profile" is a crucial resource for industry executives and anyone looking to access key information about the CRB – Saone-et-Loire Fiber Optic Network Development – Bourgogne construction project. | 2019-04-22T22:02:22 | https://www.marketresearch.com/Timetric-v3917/CRB-Saone-et-Loire-Fiber-10547572/ |
On October 2009, I pondered out loud: Is the bull back?!
Back then, we saw the stock market hit the magic Dow Jones 10,000 mark, as the indexes fought against gravity to climb up to that milestone. It’s still a ways away from the record setting 14,000 for the DJIA, which was once achieved in 2007, but it may feel like “we’re getting there.” In between 2009 and today, though, we are seeing a lot of fits and starts in the stock market, while the movement is still generally upward. It seems like our investments may have recovered somewhat, but what about the economy?
Sure, we’re supposedly in an economic recovery right now, but there are still people who are feeling the pinch of lost jobs, no jobs or upside down mortgages, as far as I’ve noticed. We’re far from celebrating here in my home state: the California unemployment rate is still hovering at around 12%, as this interactive graph shows. There’s some improvement, but not much.
What’s more concerning to me is one event that some economists are warning about: the risk of a double dip recession for our economy. For instance, I heard about how Carl Icahn (a billionaire investor) has been addressing the possibility of a double dip recession if the unemployment rate continued to rise and if people put a cap on their spending. In 2009, he thought “we were right on the precipice” of another economic contraction (quoted from this Bloomberg article). Well, it’s been a couple of years and these same fears are now back in vogue.
Then there’s Robert Shiller, the well known economist, who tells us that we’re at a “tipping point” with the U.S. economy. I came across a pretty interesting video that featured this guy, where he discusses the possibility of a recession. Note that technically speaking, the term “double dip” may or may not be applicable if you are to check actual time periods for growth and pullbacks. It’s possible that we are looking at a brand new recession anyway (rather than a double dip) based on timing, but that’s another argument for another day.
According to Shiller, standard forecasting models show that recession concerns are unfounded. However, there are some indicators and continued economic scenarios that worry him. For instance, real estate prices have not improved and there has never been a post WWII recovery without a housing recovery. No chance here for robust or sustained economic growth if housing stays in the dumps.
There have also been changes in people’s expectations of future home price increases. Some studies show that those expectations have fallen drastically. The “general market” feels that over the next 10 years, housing prices will increase 3% per year vs the buoyant 7% a year that was the answer back in 2005. Given that the 30 year mortgage rate is at 4.5%, this discrepancy points to poor confidence in the real estate sector.
Another area to look at is the situation with the global economy: rich economies are showing signs of slowdown, developing markets are showing an uptick in inflation and then there are issues with Greece’s economy. These have all been confidence shakers. We face a debt crisis (thanks to “bubble” thinking and complacency).
Finally, there are some predictions that if oil hits a certain price per barrel, we’re all doomed to recession. The main thing pointed out by Shiller is that confidence is faltering, which tends to be a big negative influence on the economy. So the bad news seems to be swirling, despite the continued optimism of professional forecasters (some government agencies and Robert Rubin don’t see the specter of a double dip).
Robert Shiller gave some direction on how our country can improve its financial outlook for the long term. Bailouts, stimulus programs and regulatory reform may have positive effects, but he suggests additional reforms in the financial industry, our financial system and in institutions. He mentions that we need a financial system that actually helps people rather than one that sends them down the wrong path (as what happened during the subprime mortgage crisis). You can expect a turnaround once fundamental improvements are made in the way the financial industry serves its customers.
I certainly agree that we need fundamental changes here. I would encourage you to check out the Shiller discussion.
We’re supposed to have recovered from the worst recession since the 1930s. A good number of people may tell you they haven’t noticed much of an economic recovery.
Unemployment numbers haven’t improved much across the board.
Interest rates are very low, but is this helping out at all?
What’s fueling the market’s rise? Improved earnings reports, apparently, but this may be a result of business cut backs and company layoffs, rather than real growth.
So how do you feel about the economy’s future?
Created Oct 14, 2009. Updated June 15, 2011. Copyright © 2011 The Digerati Life. All Rights Reserved.
My mantra is a jobless recovery is no recovery at all. After all, how can businesses get well with so many people out of work and not earning income?
I think the market’s recent rise this is a bear trap, plain and simple. I recently pulled out when the market hit 9700. I’ll buy again on the next dip. Yes, the market may go a bit higher, but the fundamentals just aren’t there to support it in the long run.
I also think inflation is inevitable – but the big question is how soon will it get here??? My fear is that when inflation does get here, the Fed will be pressured by the current administration to hold interest rates to a level that will not be high enough to effectively contain it.
@SVB – if you hear an echo, don’t worry. I agree with virtually everything that you have in this post. The rally on ‘earnings’ and the avoidance of a ‘total collapse’ don’t really tell me that stocks are cheap. All it says is that stocks are cheaper than before and they’re doing well relative to a really bad year. Then again, lots of things look good against a nasty background.
I’m not surprised to see Dow 10k, but let’s face it, there is no way that this is sustainable. Part of the problem with the double dip is the fact that so much money had to come from Fed and Treasury that even if the economy recovers strongly next year, we’ll spark inflation that will inevitably be cause for another recession…can I get another scoop of recession please…what…yeah…I’ll have some of those unemployment sprinkles too.
If you use p/e10 as a measure of value for the market, you’ll find that we’re nowhere near cheap and decidedly in the overvalued category at this level. This, coupled with the fact that even if we pull out of this recession, it won’t be a robust recovery. Besides, we still have to avert a commercial real estate meltdown.
As for unemployment, I don’t really worry about that since it’s trailing. It should stay around 10% for a few years. BTW, did you take a hard look at the last unemployment report? The percentage change in the media sounded so nice…of course, that’s because there were hundreds of thousands of workers that dropped of the statistics because they are now ‘discouraged workers’. I’m sure we’re well past 10% if we didn’t throw out this group…maybe even moving towards 15%.
Dow 10k…it’s nice, but definitely too early.
So here’s the question — if many of us virtually agree that the 10,000 level for this market is premature, then who’s fueling the market upward? People are jumping back in, but who are they — speculators? traders? momo investors? Or are there actual average joes getting suckered into a potential bear trap, as Len put it? The pain of late 2008 is still quite fresh in my mind (and yeah, just half a year ago we were writing off our retirement funds….). Too crazy too soon, I agree.
My position in the markets: one foot in, one foot out.
if many of us virtually agree that the 10,000 level for this market is premature, then who’s fueling the market upward?
March was a super bargain but most people were so battle-scarred that they couldn’t see the lows for the blood in their eyes. I wouldn’t say it was a no-brainer by any means, or a ‘dead cert’ that the market would rise, but the cheaper it gets the more the odds are stacked in your favour.
I think the move up is pretty rationale – sort of. What do I mean?
Well, if you look at economic indicators, from China’s use of raw materials to inventories as companies start rebuilding stock, there’s plenty of reason to be optimistic that earnings are going to increase.
Has this happened to a significant degree yet to justify these prices today? No, probably not. (Hence high valuations). But if it’s coming, and the more risk-hungry investors want to get on-board, they’ve been happy to buy today rather than wait for others to buy first and pay a higher price later.
Better to be early in selling a market and early in buying back in then late on both in my view!
Things do look heady now and we’re clearly not going to see another 50% rise in the next year. We will almost certainly see some small pullbacks. I don’t expect the return to March lows many seem to be waiting for but anything is possible if there’s a major ‘event’.
The trouble is ‘events’ are always possible and a worry, but mostly we only think about them after one has happened. CNBC was barely talking about a meltdown in 2007 or 1998 for that matter. Bear markets come out of the blue, not when everyone fears them, imho.
Don’t worry about unemployment — companies only begin rehiring as the last resort as they’re just as nervous as investors about the recovery.
My view is that it is fruitless to look for rational explanations of most stock market behavior. There is some rational behavior, of course, but the rational side of stock investing is so simple to figure out that it can be described in about 50 words. The productivity of the U.S. economy has for many years been strong enough to support annual gains of 6.5 percent real. Anything above that or below that is the product of emotion. An annual return of 6.5 real translates into a P/E10 level of 14 (fair value). Anything above that or below that is the product of emotion.
We were at insanely high price levels from 1996 through 2008. We toyed with the idea of going rational early this year, when we dropped to 14 (we actually went to as low as 12 for a brief time). But it scared us to let in that much truth all at once. Did you ever try to space out bad news because you could not bear to hear it all at once? You’re picking up clues that the boss you love is going to be replaced by one you know you will hate but you don’t start looking for a new job because you just cannot face something like this at the moment? That’s where we are today. We know we need to take a bigger hit than we yet have the courage to take but we prefer putting it off for a bit.
Spacing out the hit makes a certain amount of sense. But it’s irresponsible for us to push prices back to dangerous levels. Doing that greatly increases the possibility that, when we go down again, we won’t stop at 14 but will go all the way down to 8 or lower. The bigger the fall we have to take to get back to fair value, the more emotional momentum there will be on the down side. Say that the person worried about his boss being replaced decided that the way to deal with the emotional pain was to go on an expensive vacation to get his mind off his troubles. That makes it harder to deal with the job instability down the road but it provides a little temporary relief. That’s the way we are playing it today.
What most of us lack is a standard for knowing when prices are too high. People guess all the time. But the guesses are emotion-based because we don’t use a standard that applies in all markets to make the guesses. I think that the right standard is the fair-value P/E10 of 14. That permits gains of 6.5 percent real. Anything more than that is trouble and anything less than that is trouble. We all should be working to keep stock prices to what is justified by the economic realities, in my view.
You are right about all of that, and October, late in the month, is always bad for the market!
Well let’s look at the bright side. If things are going to dip later this month, the fact that this runup occurred is a good thing. It all just balances out and the dip will just take us to where we were to start with a few weeks ago… so no skin off your equity accounts, would you say?
I’m telling ya, it is absolutely a raging recovery we have here in San Francisco! Even the property markets are coming a live with multiple bids the norm again.
I’ve come away with 10 takeaways from this recession which I wrote about today. I also gave a shout out to you as well.
Until jobs come back, I won’t believe the recession is over.
Robert – the funny thing is, everybody says only when jobs come back, but then everybody is US! Is anybody not employed on this board I wonder?
I’m telling you guys, look at the data. Unemployment is a lagging indicator.
I agree it’s the most important thing morality wise — I’m all for wanting people to have jobs. But judging the recession by it is wrong. I doubt any recession has ended with rising unemployment. It always comes after, when the economy starts to grow, people can’t be pushed any harder, efficiencies have run their course, and new staff are required.
We’re supposed to be recovering from the worst recession since the 1930s. Somehow, I expect it to take more work for us to pull out of the depths of this hole.
The thing is that when we were in the depths of the recession, we kept hearing officials urge us to get out there and start spending with confidence. They said (and they say, every time there is a dip in the economy) that the worse thing you can do in a down economy is to get stingy. I don’t know how I feel about all that – I think the uptick in the stock market IS a sign that people are getting over their shell shock and are starting to buy. But I don’t think that that was the problem with the economy. We didn’t have the subprime fallout, the biggest bank bailouts in US history, the Big Three auto makers take a beating, etc., etc. because we didn’t have CONFIDENCE. There are systemic failings and, as far as I can see, there has been little reform to take care of it.
I met a man the other night who was working with the FDIC as it took over a local bank. The bureaucracy is so terrible that the Fed guys can’t even get the money to pay the utilities. And, according to the consultant (who used to work for the bank), 80% of the people working on the gov’t bank takeover weren’t even from the FDIC – they were consultants. In particular, former executives at failed banks.
I’m no expert, but I feel as if there hasn’t been enough change yet for things to be all better….
And I’m currently reading Naomi Klein’s Shock Doctrine, the thesis of which basically says that economists and corporations use “shocks” (like 9/11 and the recent economic fallout) as opportunities to prescribe more privatization and more Chicago School style economics when voters and populations are dazed and desperate. I’m worried that things are going to get worse in Wall St. rather than better. Not to mention that now there’s a whole new racket for refinancing mortgages which nets a broker a fee, but leaves the borrower with another loan they can’t pay.
This was long winded and rambling, sorry, all I meant to say was great post.
Could be the run-up is simply in anticipation of the dollar totally collapsing (e.g. big inflation). Say if the market goes up 33% but the dollar drops 50%, did it really gain anything? Or suppose we plot the market in gold instead of dollars.
This is definitely a worry for me… Here comes that ‘W’ in the graph. Looks like Gold is really worth a look again and do I dare say a price point of $2000 in the not so distant future?
The Dow Jones Index getting this far is just short of a miracle. No major job increases from the business sectors and no great increase from revenues from many companies. There are not many banks that can give out loans like there was in 2003. The reason behind the rise in the stock market is because investors are trying to buy low. Well, I believe we are at the high point of the overall market and do expect a 10% decline.
Now, my only guess is that will the major markets post a gain by the end of the year. 2007 and 2008 ending in negative years but 2009 now has a chance to finish above 0%.
I still cannot see how we get great growth in the economy and the stock market with the consumer (70% of the economy) tapped out. Where is the growth coming from without the consumer? Can foreign earnings by US corporations make up for US consumer weakness? Then there is the question of energy prices. I keep hearing conflicting reports. One minute the pundits are telling us oil prices are headed down because of a huge supply overhang sitting around on tankers unsold. The next minute you get authors like Jeff Rubin saying we will be back to three digit oil prices in the first quarter next year. See Why Your World Is About to Get a Whole Lot Smaller: Oil and the End of Globalization by Jeff Rubin. If that happens all bets are off. What do people think?
I’d like to add to these comments that here in the U.K. there is a massive problem with debt — personal debt, bank debt and government debt. If the U.S. is similar then the global economy is in deep trouble with just this factor, never mind unemployment (which reduces available taxes for Government) and the threat of inflation (which, in the U.K. could come from the Bank of England printing money). This has got to push markets down. Just my thoughts on the subject!
I think the market is improving and will be rising over time. It is important that everybody believes in it, so there will be good results.
You guys are analyzing the lawn that simply needs to be cut. Our economy is a false one…does not take Albert Einstein-Hawking to realize that. 70% of our GDP is consumer spending. Most of that spending was based on work wages/and or credit (see wikipedia for credit synonym-DEBT) China pumped the credit to fuel our insatiable penniless consumers, and then pumped their goods to justify their production.
Men should act like men…such talk emasculates them, they just don’t know it.
It’s interesting how a little over a month later that this was written, there’s now talk of a double dip! Of course, I had no idea that the country’s credit rating would get downgraded, and everything is seen in hindsight. Still, when we had the real estate boom and bust — it was the same thing: we wrote about some of the signs we were seeing that pointed to a bubble that was about ready to disintegrate. When it comes to financial crises, it’s not that hard to be proactive about taking steps to protect yourself — you can see things building and moving in the wrong direction before things get worse…. yet, people, societies and governments don’t care to react until it’s too late! | 2019-04-21T14:41:08 | http://www.thedigeratilife.com/blog/double-dip-recession/ |
Neurofeedback-Partner GmbH - Electrodes sintered silver/silver chloride - SET 7 pcs.
Main page » Supplies » Electrodes sintered silver/silver chloride - SET 7 pcs.
sintered silver chloride electrodes with excellent properties.
Reiter: description Our recommendation for all types of Neuroeedback. The sintered silver chloride electrodes from a reputed U.S. manufacturers have everything you could wish for a really good electrode. | 2019-04-21T20:42:40 | https://www.neurofeedback-partner.de/product_info.php?info=p33_elektroden-gesintertes-silberchlorid---set-7-stck-ag-agcl-kunststoffrand.html |
1g piperine and 10mL 10% alcoholic potassium hydroxide are refluxed for 90min.
piperidine hydrochloride, which melts at 244°C after recrystallization from ethanol.
usual alcohol is boiled mildly about 24h in a water-bath.
acid about 50 parts alcohol were required.
a 50mL round-bottomed flask. attach a condenser and heat at reflux for 90min.
attach the flask to an apparatus suitable for distillation under reduced pressure.
(in the hood) with hydrochloric acid. occasionally swirl the erlenmeyer flask.
with cold water, and recrystallize from hot ethanol (2).
note the odor of the distillate. check the distillate with litmus or pH paper (3).
(1) bumping may occur at this step.
this to be difficult and probably not worth the effort.
produce piperic acid in 85% yield, mp 126-127°C.
(mp 126-127°C looks like an error. it seems that 1 and 2 are permuted.
"piperine analogues for the treatment of skin conditions"
constitutive and inducible cytochrome P450 activities"
"piperonylic acid from black pepper"
"ANALYTICAL METHOD - Determination of the Pungent Constitueints of Piper nigrum" | 2019-04-26T04:14:29 | http://chemistry.mdma.ch/hiveboard/rhodium/3base/piperonal.pepper/degradation.piperine/index.html |
In 1991, Geoffrey Hill published a paper in Nature describing the results of his field experiments with house finches which showed that: 1. females choose to mate with brightly-coloured males; 2. males with brightly-coloured plumages tended to contribute more to parental care and were also likely to be of better “genotypic quality”. Twenty-five years after the paper was published, I asked Geoffrey Hill about why he chose this topic for his PhD, the challenges of carrying out these experiments, and what we have learnt since about the role of colour in mate choice in house finches.
Citation: Hill, G. E. (1991). Plumage coloration is a sexually selected indicator of male quality. Nature, 350(6316), 337.
Date of interview: Questions sent by email on 5th November 2016; responses received by email on 18th November 2016.
Hari Sridhar: Correct me if I’m wrong, but this paper seems to have formed part of your PhD thesis. Could you tell us what was the motivation behind this specific piece of work, in relation to the rest of your PhD?
Geoffrey Hill: My 1991 Nature paper was the centerpiece of my Ph.D. dissertation at the University of Michigan. My goal in conducting my dissertation research was to explain why birds have specific ornamental colors and patterns. Darwin’s hypothesis that choosing females had mating preferences for ornamental coloration had not been tested in birds. Work on mate choice for coloration in guppies had just been published by John Endler and Astrid Kodric-Brown, and I was anxious to try to conduct “definitive” experimental tests of choice for color in birds. The Nature paper presented the results of a field experiment, and I published the results of lab experiments with caged birds in a companion paper in Animal Behaviour.
HS: Stepping back a bit, could you tell us what got you interested in the topic of bird coloration in the first place? Also, how did you pick house finches as your study species?
GH: I completed a master’s degree at the University of New Mexico before entering a doctoral program at Michigan in 1986. My master’s research focused on explaining delayed plumage maturation in songbirds. I picked that topic because it was a topic of interest among behavioral ecologists in the early 1980s. In bird species with delayed plumage maturation, males do not attain full-blown breeding plumage in their first year even though they are sexually mature; they have drabber plumage that often makes them look like females. Several hypotheses had been proposed to explain delayed plumage maturation, and I tried to test these competing hypotheses in my master’s research. I soon realized, however, that it was rather pointless to try to explain age-specific plumage coloration when we had no real understanding of coloration in any context. I came to the University of Michigan determined to “figure out” coloration in birds and by extension ornamentation in animals generally.
I decided to focus on carotenoid coloration, which was almost unstudied in birds at the time, because of an obscure statement in an ornithology text by Joel Welty: “Canaries will, in successive molts, gradually change from yellow to intense orange if fed red peppers.” Condition dependent sexual signaling was a new and exciting topic in behavioral ecology when I read that statement about canary coloration in the early 1980s. The prospect of diet-dependent coloration sounded intriguing to me. Then, when I went to the literature to find out more about carotenoid coloration in birds, I found a paper published in 1976 in The Auk on pigmentation in House Finches. In that paper, Alan Brush and Dennis Power used thin layer chromatography to identify the carotenoid pigments in House Finches, one of the first characterizations of carotenoid pigments in feathers in any bird. House Finches were an invasive species in Michigan, having just colonized the area a few years before I arrived in Ann Arbor, and they seemed to be a perfect study bird. So, in 1987, I started capturing wild House Finches and visually quantifying their feather coloration.
GH: In the 1980s, the evolutionary biology program at Michigan was not what we might call a nurturing environment for grad students. Students were expected to devise their own research projects, get their own funding, and prove they had potential as research biologists. The attrition rate was high. I designed, funded, and executed my thesis research without help from my advisor, so there was never any consideration of putting his name on the paper. My dissertation had six chapters, and I published all six as single-authored papers. I’m proud to say that all six of my single-authored dissertation chapters have each been cited more than 100 times. It was a swim-or-drown environment at Michigan in the 1980s, but once I started swimming, it did make the transition to independent faculty member relatively easy.
HS: Could you give us a sense of what your daily routine was like during the fieldwork for this study – How did you commute to your field site? Who were the people who helped you with fieldwork? etc.
GH: In choosing the House Finch as my study organism and the University of Michigan campus as my field site, I consciously traded the joys of working in a wild setting for the practicality of a tractable system in which I could conduct experiments. My plan was to study House Finches both in the wild and in captivity. The “wild” for House Finches was the main university campus – finches nested in shrubs and in ivy on the sides of buildings and they fed on weed seeds in the lawns. I started my finch project in the summer of 1987, capturing wild birds in backyards around the area to create a captive flock in the rooftop aviary at Michigan. I didn’t take birds from the campus population because I wanted those for my field study.
Once the breeding season started in March, my days were frantic. I would typically ride a bus to campus before first light, set up a mate choice trial that ran for 3 hours, then grab binoculars and head for fieldwork (out the front doors of the museum). About two days per week, I would trap and color band the local population of finches. In the second year of the field study, I used hair dyes to change the coloration of the males that I caught. That color-change experiment was the basis for my 1991 Nature paper. On other days, I would walk around campus with my binoculars recording the behavior of banded birds with a special focus on pairing. After about two and a half hours of field work, I’d run back into the museum, literally run up 5 flights of stairs to the roof, set up birds for the second mate choice trial of the morning, and then go back out for more field work. That field season kept me in great physical shape. When birds started nesting, I was often grabbing a ladder (a really big and heavy ladder) to go out and climb to nests to check contents or band chicks. This routine didn’t stop until the end of July when the finches had finished nesting.
HS: You say you used hair dyes, hair lighteners and colour developer for your experiments. Could you tell us a little more about this – Who came up with the idea of using these? Did you try any other options before deciding on this? Do you remember what particular brands of these chemicals you used? etc. Do you continue to use the same in experiments even today?
GH: Devising a means to change the coloration of birds was one of the most challenging parts of my research. Making birds redder was not so hard. There were red art markers that would increase plumage redness. But I also wanted to decrease redness, which was not easy and for which there were no published methods. I tried calling experts in bird coloration around the country like Sievert Rohwer at the University of Washington and Ken Parkes at the University of Pittsburgh. All of the senior zoologists who I contacted encouraged me to do the experiments, but they had no useful advice to offer regarding how to lighten the red coloration of finches.
I was starting to think that I would have to abandon the experiment or do it only by adding red to feathers when it suddenly occurred to me who I needed to consult: the real experts in manipulating the color of integument, beauticians. I looked in the phone book, found the address for a beauty supply shop, and drove over. It was both a salon and store, and those women really were experts on manipulating coloration. And when I explained my research project, they were extremely sharp and insightful consultants. In retrospect, I should have taken down their names and acknowledged them in the paper. They set me up with a strong hair lightener that was designed to remove melanin pigmentation from hair and that I hoped would remove carotenoids from feathers. Fortuitously, non-traditional hair colors were popular by the 1980s in Ann Arbor, so they had permanent, scarlet red hair dyes.
It all worked amazingly well, but it was a rather harsh experimental treatment for the birds. First, because birds coat their feather with oil from their uropygial gland, I knew I would have to strip oil off the feathers for dye to adhere to the feather substrate. So, I had to lightly shampoo the feathers of the birds before the color treatment. Getting birds wet to the skin is dangerous because they lose all insulation and can go hypothermic very fast, so I used warm water and worked fast. Immediately after the shampoo treatment, the birds either had red dye or hair lightener worked into their feathers. Both of these products had to be left on the feathers for 15 minutes to set, so I would wrap the bodies of the birds from the neck down in plastic wrap and then set the birds on a heat pad to keep them warm. The heat also helped the dyes and lighteners work. Finally, I had to rinse out the dye or lightener and then let the birds dry, fluff, and preen. Again, wet birds are at serious risk of hypothermia even in a relatively warm room, so I put the birds in cages in front of heat lamps. Heat lamps were dangerous for birds because a small bird can go from warm to over-heated very fast. To avoid that, I shielded half of the cage from the lamp so birds could move out of the heat if they got uncomfortable. The whole process worked really well and I didn’t lose a single bird during this dying process. I held the birds overnight to recover and within a few hours of the last rinse, they were fluffed and preened and looked like normal house finches again.
Since that experiment, I have run several experiments with my students in which we increased the coloration of red, yellow, and blue species with art markers, but I have never gone back to the dye treatment.
HS: Do you continue to work in this site? When was the last time you visited this place? Has it changed in any way from the time you worked there? Are house finches still common there?
GH: I did a last field season on the site in the summer of 1991 after I defended my dissertation in April, but when I drove away in June 1991 I was done forever with the House Finch population on the campus of the University of Michigan. Five years after that 1991 field season, a new passerine disease, Mycoplasma gallisepticum, swept through the eastern population of finches killing about half of the population. The eastern population has not rebounded from the effects of this disease, and finches in the east remain about half as abundant as they were in the early 1990s. I assume that the Ann Arbor population is about half as large as it was when I studied it.
HS: How long did the writing of this paper take? When and where did you do most of the writing? You acknowledge a number of people who commented on the manuscript – could you tell us who these people were and how you knew them at that time?
GH: I wrote this paper quickly, perhaps in two weeks for the first submitted draft. I’ve always been efficient at getting ideas down on paper. Also, as solo author, I wasn’t delayed waiting for anyone else. I worked at my own pace.
Then and now, I do almost all of my writing at my desk at the university. I find home too distracting. At the University of Michigan, I was in an office suite with two desks in my room and two desks in the attached room. Phil Chu was my roommate, while in the room next door was Rick Prum and Rebecca Irwin. Anyone interested in bird coloration will know the name Prum (Richard O Prum) who was not working on coloration in the 1980s when we were office mates but who started working on coloration in 1990s and did many important and groundbreaking studies. It was a great group of young scientists and down the hall was Michael Nachman (now director of the MVZ [Museum of Vertebrate Zoology]), Steve Dobson (now on faculty with me at Auburn), Kyle Summers, Steve Frank, Lyle Gibbs and many other students who are now prominent professors. It was my graduate student and postdoc colleagues who were my advisors and sounding boards, much more so than the professors. I cannot remember every discussing my dissertation ideas with any faculty member, but I discussed my ideas incessantly with my grad student and postdoc colleagues. As I go back and look at the acknowledgements in the paper, I listed my doctoral committee and no one else. In retrospect, I should have acknowledged my grad student and postdoctoral colleagues who helped me think through the design of that experiment.
HS: How did you draw the figures for this paper?
GH: There is only one figure, and it is really pretty terrible. I used to generate all of my graphics using a statistics program called Statview on an early generation Macintosh computer. I would create graphical summaries of data in PICT format that I could then import into a draw program. I really miss those old stats and drawing programs.
GH: I was a very young and naïve grad student when I sent that paper off to Nature. I just wrote it up and put it in the mail. (Yes, you still actually photocopied and mailed manuscripts in the early 1990s.) I don’t know what the rate of rejection without review was in 1990 (it is about 60% now), but my manuscript received a full review. In the decision letter, the editor, Rory Howlett, used the word “reject”, and I thought my paper was rejected. About a week after I got my decision letter from Nature and when I was getting ready to start to rework it for a new journal, I mentioned to my grad student friend and colleague, Michael Nachman (now director of MVZ at Berkeley), that I had had a paper rejected by Nature. He had never seen a decision letter from Nature and asked if he could see it. I’ll never forget his face as he read the letter. He looked up from the letter and said “Geoff, this is not a rejection letter. This is a tentative acceptance letter. They want you to revise the paper and resubmit!”. I was completely clueless. I had seen the word “reject” and assumed Nature didn’t want it. Thank goodness Michael was there to coach me. So I revised the paper, wrote a response to the reviewer’s critiques, and the next letter I got was “you will receive proofs in a month”.
GH: The Nature paper got no special attention at all, so far as I could tell. I submitted House Finch photos for the cover, but Nature used a map of Antarctica on the cover instead. My house finch study seemed buried amongst the cell biology and physics. There was zero press about the paper. No one even mentioned it to me the week it came out.
GH: It is hard to assess the impact on my career. I was struggling to get a postdoctoral position toward the end of my graduate program at Michigan, and according to my eventual postdoc advisor, Bob Montgomerie, the Nature paper made a big difference in earning an NSERC postdoc in Canada. So, it likely got me a postdoctoral fellowship when I really needed one, and it was likely a factor in getting me an interview and eventually a faculty position at Auburn University.
HS: Today, 25 years after it was published, would you say that the main findings still hold true, more-or-less?
GH: I would say that the central finding holds up better than more-or-less. The take-home message from the Nature paper is that female House Finches show a mating preference for red carotenoid coloration, which is a condition-dependent signal of male quality. That core finding has been corroborated with other studies of House Finches both by my lab group and by other lab groups, and the observation that red coloration is an important criterion in female mate choice has been demonstrated in other species of birds as well.
HS: If you were to redo this study today, would you do anything differently, given the advances in technology, theory, statistical and lab techniques etc.?
GH: Looking back 25 years later, I think that I got substantially off track in my early studies of condition-dependent signaling by focusing so much on carotenoid as a limiting resource and by pushing resource limitation as the basis for honest signaling. Ironically, the resource limitation idea caught on so well that it is now dogma in the field of sexual signaling even as I have concluded that it is, for the most part, incorrect. I now have my own studies from 20 years ago cited against my new ideas. But, none of this rethinking concerns female mate choice for carotenoid coloration, which is the focus of the Nature paper. I would repeat the experiment in the same way, with the same basic experimental design.
HS: This paper has been cited close to 700 times. At the time of the study, did you anticipate at all that it would have such a big impact? Would you know what it is mostly cited for?
GH: I conducted this study because I knew there was a critical need for a test of female mate preference for ornamental coloration. Moreover, I knew that tying such a mating preference to condition-dependent signaling would draw people’s attention. I can’t say that I am really surprised by the modest success of the paper.
HS: You say “In all comparisons, returning males were significantly more colourful than males that did not return , suggesting that colourful plumage is an indicator of male viability and perhaps genetic quality , although the relationship between colour and viability might be due to phenotypic effects.” Today, do we know more about the relationship between colour and viability?
GS: We are just starting to understand how coloration connects to organismal performance, including viability. Earlier this year (2016), I was part of a team that discovered the gene that enables House Finches and other songbirds to convert yellow dietary pigments to red pigments. This is the key gene whose activity determines whether an individual finch will be more or less red. Now that we know the identity of this key redness gene, we can investigate how its function links individual carotenoid coloration to individual performance and ultimately viability. We have a grant pending to fund such a study and my grad students are already collecting data to test hypotheses for how this might work.
HS: You found a significant correlation between plumage of fathers and sons and say “Although this correlation fits predictions of the ‘good genes’ models, it could also be due to maternal or paternal effects as colourful males tend to provide more food and probably pair with higher quality females than drab males.” Do we know more about the reason for this correlation today?
GH: We really do not know any more about heritability of red coloration in male House Finches now than we did in 1991. We are further along in building fundamental understanding of the genetic basis for coloration now, and so I think we are closer to an answer. A major focus of my lab going forward is to use functional genomics techniques to understand how gene regulation and inherited genetic variation might contribute to color variation among males.
GH: Yes, in the early 1990s I ran a graduate class “Advanced Ornithology” in which we focused on feather coloration and ideas related to honest signaling. The paper was assigned reading and I re-read it in preparation for class. I’m not like an actress or actor who states that they never watch their own movies. I re-read my own papers all the time, often because I have to remember what I wrote.
GH: A few years ago, on my lab web page, I started a list of the “25 most impactful Hill lab papers”. I currently [18th November 2016] have the 1991 Nature paper listed as the 8th most impactful paper out of about 200 that I have published. Among the seven papers that I rated above it, the oldest is 2011. So, in my mind, it was 20 years before I wrote a more impactful paper than the central paper in my doctoral dissertation. I’ve made a conscious effort over recent years to write fewer but more meaningful papers like my 1991 Nature paper, so I would definitely say that it is one of the papers of which I am most proud.
HS: What would you say to a student who is about to read this paper today? What should he or she take away from this paper written 25 years ago? Would you add any caveats?
GH: I would advise a student who was about to read the paper to consider that this Nature paper was the summary of a simple experiment conceived of and executed by a young graduate student. Inexperience is an obvious hindrance to a young person creating cutting-edge science, but a fresh perspective, freedom from accumulated biases and skepticisms, and naivety that enables “impossible” tasks to be attempted can be a huge counter to the inexperience. I would encourage the student that there are innumerable simple, high-impact studies waiting to be conducted. | 2019-04-23T14:08:01 | https://reflectionsonpaperspast.wordpress.com/2018/02/11/revisiting-hill-1991/ |
Gunung Lebah Temple is a historic temple which stands on a protruded rock in Ubud. The temple was built in the 8th century and is popular tourist attraction.
The name of this temple translates to ‘small hill’ in the local dialect, a fact that can be attributed to its location at the valley where the tributaries of Sungai Cerik merge.
Located about 2kms west of the popular Ubud market, Gunung Lebah Temple is associated with the origins of the tourist town Ubud. Enthralled by the picturesque valley and the soothing waters of the two rivers, the High Priest Rsi Markendya decided to build a temple on the grounds, which is today known as Pura Gunung Lebah.
The temple, which remains open 24 hours a day, allows both visitors and pilgrims on a quest for a deeper meaning. To get to the temple, visitors need to access Jl Raya Campuan as the temple is off this road. For the best views, it is advisable to visit the temple in the morning. At this time, the temple is not packed with tourists, and you can enjoy the solitude for a moment or two of reflection.
On arrival, visitors are asked to donate at the temple as part of entrance fees (usually between 10,000-20,000 IDR is appropriate). Visitors must ensure that they wear a sarong to cover knees and ankles. Also make sure that shoulders and midriffs are covered. If you do not have your own sarong, you can hire one at the entrance for around 15,000 IDR.
15,000 IDR to hire sarong. | 2019-04-19T20:42:59 | https://www.balitravelhub.com/attractions/temples/gunung-lebah-temple/ |
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If visitors have any questions about the security on https://garudarom.id, feel free to contact Customer Service. | 2019-04-21T07:14:44 | https://garudarom.id/privacy-policy-2/ |
What’s the weather in Passo Fedaia - Marmolada today? See an overview of the current Passo Fedaia - Marmolada weather, including high and low temperatures for the day and wind mph at the base and summit of the mountain. Scroll to the right to see Passo Fedaia - Marmolada weather forecasts and wind for the next seven days. Tab over to Hour by Hour for an hourly Passo Fedaia - Marmolada weather forecast breakdown or to Long Range Weather Forecast for a detailed Passo Fedaia - Marmolada weather forecast for the next seven days.
Get Snow Reports, Powder Alerts & Powder Forecasts from Passo Fedaia - Marmolada straight to your inbox! | 2019-04-24T04:50:24 | https://www.onthesnow.com/trentino/passo-fedaia-marmolada/weather.html |
Experts at merging form with function, we translate the most relevant apparel and home decor trends into fashion-forward products across a range of styles, price points and categories Ð including rugs, pillows, throws, wall decor, lighting, accent furniture, decorative accessories and bedding. From classic to contemporary, our selection of inspired products provides fresh, colorful and on-trend options for every lifestyle and budget.Looking for a great entry wall piece that guests will notice when they walk in the door? Suryas striking mirror will fit the need. | 2019-04-19T05:00:32 | https://www.rugpal.com/surya-oleander-contemporary-mirror-collection-29364.html?color=champagne&id=1530268 |
This is the Arkansas Game and Fish Commission’s fishing report for Oct. 24, 2018. If there is a body of water you would like included in this report, please email AGFCfishingreport@outlook.com with information on possible sources for reports about that lake or river. Reports are updated weekly, although some reports might be published for two weeks if updates are not received promptly or if reporters say conditions haven’t changed. Contact the reporter for the lake or stream you plan to fish for current news. | 2019-04-22T04:01:40 | http://kawx.org/kawx-news/387053 |
Like the Marvin Gaye song, ain’t nothing like the real thing, baby.
Boxed & pre-packaged foods are a convenient, easy happy, but what are the tradeoffs?
Additives that make food cheaper and easier are higher in fats, sugars, and salts in larger portions, provide less taste and less nutrition, but more weight on you and your family.
You know you’re getting out of the packaged food phase of your cooking when you start mixing this and that prepared food to create another.
Let us take you one step further on your culinary thousand-mile journey.
Ingredients are like musical notes. Let me show you how to make them sing!
Stock your pantry, refrigerator, and freezer with more basic staples and spices, and turn even a small kitchen into a source of limitless creation.
Let me and my team show you how! | 2019-04-25T14:03:12 | http://thejazzchef.com/less-boxed-more-basics/ |
. (Radio.com) Following the upcoming release of Britney Spears' eighth album, Britney Jean (out Dec. 10), the singer will reveal another piece of herself in a new documentary.
The 90-minute TV special, I Am Britney Jean, will air on Sunday, Dec. 22 on E! and will follow the singer as she prepares for her two-year Las Vegas residency, Britney: Piece of Me, which kicks off five days later on Dec. 27. | 2019-04-22T13:05:40 | http://www.antimusic.com/news/13/November/15Britney_Spears_Documentary_Coming_This_Christmas.shtml |
Australian made, galvanised steel car trailer. Connects direct to your vehicle, 4WD, utility or truck via a standard 50mm tow ball hitch. Ideal for moving heavier vehicles such as a 4WD Land Cruiser or dual cab ute. | 2019-04-26T02:33:17 | https://www.megahire.com.au/products/hire-car-trailer-heavy-duty-3-5-atm |
Let’s tiptoe through the tulips together and discover the sights, sounds and smells of the garden. This half term, we’ll visit a florist’s shop or a garden centre. We’ll find out how to look after plants, ask the experts questions and appreciate the flowers. We’ll write an information book about plants, follow instructions, enjoy the story of Jack and the Beanstalk and write stories of our own. Discovering our green fingers will be fun when we plant and tend a pizza garden of herbs. We’ll also learn about the different parts of a plant and create our own ‘planting and growing’ action rhyme. Our senses will help us describe and sort a range of smells and we’ll make beautifully scented products. We’ll look closely at a wide variety of plants, create detailed, observational drawings and press real flowers to use in collages.
Climbing the battlements or tunnelling in the ground, there’s a whole world of adventure and fun to be found! This term, we will visit The Tower of London to explore the towers, battlements and maybe a secret tunnel or two! We’ll learn all about the different parts of a castle and describe how they have changed over time. Using a wide range of materials, we’ll build models of castles and test the strength of our structures. We’ll read ‘The Tunnel’ written by Anthony Browne and create our own mysterious stories with lots of descriptive language. Maps and photographs will help us learn about the tallest buildings and the longest tunnels in the world. We’ll find out about the amazing Victorian engineer, Isambard Kingdom Brunel, and improve our PE skills by playing attacking and defending games.
Click on the correct date below to download the home learning pack for that week.
Topics covered this term: Place Value, Addition and Subtraction, Multiplication and Division.
Children in Year 2 will become secure with the place value of 2-digit numbers.
This BBC Bitesize guide has all you need to know!
It is also vital the children are practising their times-tables!
By the end of Year 2, children need to be secure in their recall of the 2, 5 and 10 times tables.
Click here to visit Anthony Browne's website - There are a few activities you can do, plus can contact him on here too!
Check back here for more useful links and resources to support your child's learning.
If you have any suggestions for content, please speak to your child's class teacher.
Please note that the links contained in these pages will direct you to external websites. Servite RC Primary School takes no responsibility for the content or advertisements contained on these sites and the links are not an endorsement of the website or organisations that control them. | 2019-04-19T02:37:43 | https://serviteprimaryschool.co.uk/Parents/Year-2/ |
Replacing a toilet (Figure 1) is not a complex project, however it does require some physical strength and in many cases the ability to work in tight, and constricted areas.
Toilet – either one piece or a bowl and tank combo (Two piece) (Figure 1).
Toilet Gasket – wax or urethane ring that seals the base of the toilet bowl to the drainpipe flange.
Toilet Flange Bolts – brass bolts that fasten the toilet bowl to the drainpipe flange and holds the toilet snuggly against the floor.
Flexible Water Supply Line – provides connection from the water valve to the float valve in the toilet tank. Water supply lines are available in two standard lengths; 12 and 20 inches.
Items 2, 3 and 4 are all available individually or in kit form as shown in Figure 2. The kit is usually less expensive than buying each of the parts individually.
In some cases, you may also need to purchase a toilet seat or reuse the one from the toilet you are removing. You may also want to purchase the caps that cover the toilet flange bolts.
Water Pump Pliers (Figure 3) – this is the easiest tool to use to tighten the water supply connection to the toilet tank. However a medium size adjustable wrench will also work.
Adjustable Wrench or Wrench Assortment – used to tighten the nuts on the flange bolts, the nuts on the bolts that mount the tank to the bowl and to tighten the water supply line to the water valve.
Large Screwdriver – used to hold the bolts in place that tighten the tank to the bowl.
Small Scraper – needed to scrape any old gasket material off the floor flange.
Deep Socket Set - not a mandatory requirement, but they do make the assembly much easier.
Remove the toilet seat if it is going to be reused. Two bolts go through the hinge assembly (you may have to pop up a cap that hides the head of the bolt) on the back of the toilet bowl. The nuts are located under the rim of the bowl.
Remove the lid on the toilet tank and sponge out any remaining water. Note: The toilet has a water trap molded into the bowl. Hence, there will be residual water left in the toilet, below the bowl.
Undo the nut that connects the water supply line to the toilet.
Remove the nuts on the bolts on the base of the toilet bowl. These may be covered by caps that can be removed by placing the tip of a screwdriver between the edge of the cap and the bowl.
Lift the toilet straight up to clear the flange bolts. As pointed out in item 5, there is still water in the trap molded into the base of the toilet bowl. Tipping the bowl left to right or front to back will cause the water in the trap to flow onto the floor!
Remove the two flange bolts and discard.
Remove any gasket material that remains on the flange.
Remove the water supply pipe at the valve end and discard.
Install the new water supply pipe to the valve.
Install the new flange screws in the slots in the flange.
Install the flange gasket on the base of the toilet bowl.
Lift the toilet bowl above the height of the screws and lower so that the two flange bolts appear through the holes in the base of the toilet bowl.
Tighten the bowl to the flange by alternate tightening of the two nuts on the flange bolts. Don’t forget to install the flange bolt cover bases, if applicable, over the bolts before placing the nuts on the bolts.
If you have installed the bowl without the tank then install the tank to the bowl at this time.
Connect the water supply line to the bottom of the tank bowl float valve. It is always wise to use some pipe thread tape on any threaded pipe fittings to help prevent leaks.
Turn the water on and look for leaks.
Install the flange bolt caps if applicable. It may be necessary to cut the height of the bolts with a hacksaw in order for the caps to fit.
Place cover on top of the toilet tank.
If you need to raise the drainpipe flange in order to have it level with the surface of the floor you should use a toilet extension flange, as shown in Figure 4.
CAUTION: All toilets are molded from porcelain, which is a very brittle material. Tightening any bolts, with to much force, may cause the porcelain to crack! | 2019-04-18T23:06:49 | http://www.renovation-headquarters.com/toiletreplacement.html |
Fun Fact #48 Which poet has a pocket park honoring her in Nob Hill?
Park designer John Lauren c. 1995 Courtesy Oregon Cultural Heritage Commission.
Hazel Hall began writing at age 9- three years later she contracted scarlet fever. Scarlet fever is treatable today with antibiotics and many of us have had strep throat with a high fever; there was no treatment offered in 1898 and she was left paralyzed. She spent most of her life inside a small home in Portland’s Nob Hill, wheelchair bound, sewing for a living and writing poetry for her soul. On Mother’s Day in 1995, a small park was opened to the public, it replaced a few parking spots next to the home where Hazel Hall died in 1924. The park north of 106 NW 22nd Place was funded by the Oregon Cultural Heritage Commission the outstanding feature of the park is the granite markers engraved with her poems.
Copyright © 2019 Slabtown Tours – NW Portland Walking Tours. Powered by WordPress. Theme: Accelerate by ThemeGrill. | 2019-04-20T14:30:27 | http://slabtowntours.com/2019/03/ |
201 Lake Street is the perfect accommodation base to discover everything Cairns and Tropical North Queensland has to offer. 201 Lake Street is conveniently located just off The Esplanade and just a relaxed stroll into Central Cairns.
The Great Barrier Reef stretches over 2,600km along Queensland Coast. Explore coral cays and pontoons on the Outer Reef or cruise the islands along the coast. Enjoy snorkeling, diving, glass bottom boats and semi-submersible tours. Our tropical rainforests are the oldest on earth, covering almost 900,000 hectares. Explore the Daintree rainforest and Cape Tribulation, Cairns Highlands and Mission Beach. All pre-organised tours pick up from the resort.
Cairns dining options range from casual takeaway to first-class restaurants. Journey into the Daintree for a ‘Flames of the Forest’ dinner or discover the magic of indigenous culture at Tjapukai. | 2019-04-26T10:35:23 | https://www.201lakestreet.com.au/location/ |
FTzM holds the public competition on "Digital Learning: Reality, Science & Fiction" every year and a half at the fraMediale. Teachers and students are invited to submit not only experiences and best practice examples but also sustainable ideas and concepts for the use of digital media to facilitate teaching and promote learning in educational settings.
We are seeking creative and sustainable educational media projects or concepts that present ideas for institutional teaching and learning in the digital age.
Numerous teachers and students are already using digital media in schools and universities to facilitate teaching and promote learning or have ideas of how digital learning and teaching could develop in the future. But they seldom have the opportunity to share their ideas and experiences. The competition is therefore a forum for sharing these ideas and concepts with the public.
The goal of the fraMediale prize is not only to document practical experiences but also sustainable ideas for teaching and learning with digital media in educational institutions. Furthermore, successful educational media projects are to be given a stage so they can be transferred to other learning settings or serve as inspiration for educational institutions. | 2019-04-19T19:18:04 | http://ftzm.de/en/media-education/framediale-prize |
Continental Certification INCLUDED!!! 30 Days or 1000 miles of PROTECTION!!! This 2017 Nissan Sentra SV boasts features like a push button start, braking assist, stability control, traction control, anti-lock brakes, dual airbags, side air bag system, digital display, and airbag deactivation and will not disappoint. Drive away with an impeccable 4-star crash test rating and prepare yourself for any situation. It has great mileage with 29 MPG in the city and 37 MPG on the highway. Drivers love the timeless dk. blue exterior with a marble gray interior. Don't regret waiting on this one! Call today to schedule your test drive. At Continental Nissan We pride ourselves on our customer service. Have a quick look around, we are the TOP RATED Nissan Dealer in the state! We make our customers HAPPY!!! Call us TODAY @ 708.295.3074. *Get Today's Price is available to all customers and can also be obtained by calling or coming into the dealership today. Purchase prices do not include tax, title, license and $179.81 doc fee, or Maintenance. Please verify all information. Contact Information: Continental Nissan, 5750 S. Lagrange Rd, Countryside, IL, 60525, Phone: (708) 352-9200, E-mail: dpecho@continentalnissan.com.
Continental Certification INCLUDED!!! 30 Days or 1000 miles of PROTECTION!!! This 2017 Nissan Sentra S boasts features like a braking assist, stability control, traction control, anti-lock brakes, dual airbags, side air bag system, digital display, and airbag deactivation and will not disappoint. This one's a keeper. It has a crash test safety rating of 4 out of 5 stars. Rocking a sleek silver exterior and a charcoal interior, this car is a great pick. It has the best mileage with 29 MPG in the city and 37 MPG on the highway. Call and schedule your test drive today! At Continental Nissan We pride ourselves on our customer service. Have a quick look around, we are the TOP RATED Nissan Dealer in the state! We make our customers HAPPY!!! Call us TODAY @ 708.295.3074. *Get Today's Price is available to all customers and can also be obtained by calling or coming into the dealership today. Purchase prices do not include tax, title, license and $179.81 doc fee, or Maintenance. Please verify all information. Contact Information: Continental Nissan, 5750 S. Lagrange Rd, Countryside, IL, 60525, Phone: (708) 352-9200, E-mail: dpecho@continentalnissan.com.
Continental Certification INCLUDED!!! 30 Days or 1000 miles of PROTECTION!!! If you're shopping for a quality vehicle with perks such as a stability control, traction control, a MP3 player, anti-lock brakes, dual airbags, side air bag system, digital display, and airbag deactivation, this 2015 Chevrolet Trax LS may be the car for you. This safe and reliable crossover has a crash test rating of 5 out of 5 stars! Flaunting a dazzling white exterior and a jet black interior. Don't regret waiting on this one! Call today to schedule your test drive. At Continental Nissan We pride ourselves on our customer service. Have a quick look around, we are the TOP RATED Nissan Dealer in the state! We make our customers HAPPY!!! Call us TODAY @ 708.295.3074. *Get Today's Price is available to all customers and can also be obtained by calling or coming into the dealership today. Purchase prices do not include tax, title, license and $179.81 doc fee, or Maintenance. Please verify all information. Contact Information: Continental Nissan, 5750 S. Lagrange Rd, Countryside, IL, 60525, Phone: (708) 352-9200, E-mail: dpecho@continentalnissan.com.
Certified Special FINANCING!! AVAILABLE!!! Nissan Certified 7y/100k Limited Powertrain Warranty INCLUDED! Unlike dealers in the Chicagoland area We do not up charge for Certification or Reconditioning! Nissan Certified Pre-Owned Details: * 167 Point Inspection * Roadside Assistance * Powertrain Limited Warranty: 84 Month/100,000 Mile (whichever comes first) from original in-service date * Warranty Deductible: $50. This 2015 Chevrolet Equinox LS boasts features like a braking assist, hill start assist, stability control, traction control, a MP3 player, anti-lock brakes, dual airbags, side air bag system, digital display, and airbag deactivation and will not disappoint. It also includes Roadside Assistance, Courtesy Transportation. This vehicle also comes with 12,000 warranty miles and has been subjected to a rigorous, 172 -point inspection for condition and appearance. Don't skimp on safety. Rest easy with a 4 out of 5 star crash test rating. The exterior is a charming black. Call and schedule your test drive today! At Continental Nissan We pride ourselves on our customer service. Have a quick look around, we are the TOP RATED Nissan Dealer in the state! We make our customers HAPPY!!! Call us TODAY! @ 708.295.3074 *Get Today's Price is available to all customers and can also be obtained by calling or coming into the dealership today. Purchase prices do not include tax, title, license and $179.81 doc fee. Please verify all information. Contact Information: Continental Nissan, 5750 S. Lagrange Rd, Countryside, IL, 60525, Phone: (708) 352-9200, E-mail: dpecho@continentalnissan.com.
Continental Certification INCLUDED!!! 30 Days or 1000 miles of PROTECTION!!! With features like hill start assist, stability control, traction control, anti-lock brakes, dual airbags, side air bag system, digital display, and airbag deactivation, this 2016 Kia Soul + is a must-have ride. This crossover is one of the safest you could buy. It earned a crash test rating of 5 out of 5 stars. The exterior is a timeless black. This is the vehicle you have been waiting for! Call now to schedule a test drive! At Continental Nissan We pride ourselves on our customer service. Have a quick look around, we are the TOP RATED Nissan Dealer in the state! We make our customers HAPPY!!! Call us TODAY @ 708.295.3074. *Get Today's Price is available to all customers and can also be obtained by calling or coming into the dealership today. Purchase prices do not include tax, title, license and $179.81 doc fee, or Maintenance. Please verify all information. Contact Information: Continental Nissan, 5750 S. Lagrange Rd, Countryside, IL, 60525, Phone: (708) 352-9200, E-mail: dpecho@continentalnissan.com.
Certified Special FINANCING!! AVAILABLE!!! Nissan Certified 7y/100k Limited Powertrain Warranty INCLUDED! Unlike dealers in the Chicagoland area We do not up charge for Certification or Reconditioning! Nissan Certified Pre-Owned Details: * 167 Point Inspection * Roadside Assistance * Powertrain Limited Warranty: 84 Month/100,000 Mile (whichever comes first) from original in-service date * Warranty Deductible: $50. This 2014 Nissan Rogue Select S is a great option for folks looking for top features like a braking assist, a power outlet, stability control, traction control, anti-lock brakes, dual airbags, side air bag system, digital display, and airbag deactivation. It also includes 24-hour Emergency Roadside Assistance, Car Rental Reimbursement and Towing Benefit, CARFAX Vehicle History Report, SiriusXM Satellite Radio with 3-month trial subscription, Optional Security+Plus Extended Protection Plan. This vehicle also comes with 100,000 warranty miles, and 7 warranty years and has been subjected to a rigorous, 167 -point inspection for condition and appearance. Drive away with an impeccable 4-star crash test rating and prepare yourself for any situation. The exterior is a suave pearl white. Don't sit on this decision for long...schedule your test drive today! At Continental Nissan We pride ourselves on our customer service. Have a quick look around, we are the TOP RATED Nissan Dealer in the state! We make our customers HAPPY!!! Call us TODAY! @ 708.295.3074 *Get Today's Price is available to all customers and can also be obtained by calling or coming into the dealership today. Purchase prices do not include tax, title, license and $179.81 doc fee. Please verify all information. Contact Information: Continental Nissan, 5750 S. Lagrange Rd, Countryside, IL, 60525, Phone: (708) 352-9200, E-mail: dpecho@continentalnissan.com.
Continental Certification INCLUDED!!! 30 Days or 1000 miles of PROTECTION!!! Don't miss out on this 2013 Nissan Rogue S! It comes with a braking assist, a power outlet, stability control, traction control, anti-lock brakes, dual airbags, side air bag system, and airbag deactivation for an even better ride. With a crash test rating of 4 out of 5 stars, everyone can feel secure. Rocking a suave graphite blue metall exterior and a black interior, this car is a sight to see from the inside out. Interested? Call today and schedule a test drive! At Continental Nissan We pride ourselves on our customer service. Have a quick look around, we are the TOP RATED Nissan Dealer in the state! We make our customers HAPPY!!! Call us TODAY @ 708.295.3074. *Get Today's Price is available to all customers and can also be obtained by calling or coming into the dealership today. Purchase prices do not include tax, title, license and $179.81 doc fee, or Maintenance. Please verify all information. Contact Information: Continental Nissan, 5750 S. Lagrange Rd, Countryside, IL, 60525, Phone: (708) 352-9200, E-mail: dpecho@continentalnissan.com.
Continental Certification INCLUDED!!! 30 Days or 1000 miles of PROTECTION!!! This Black 2010 Honda Odyssey EX-L might be just the mini van for you. It comes with a 6 Cylinder engine. The exterior is a classic black. Interested? Don't let it slip away! Call today for a test drive. At Continental Nissan We pride ourselves on our customer service. Have a quick look around, we are the TOP RATED Nissan Dealer in the state! We make our customers HAPPY!!! Call us TODAY @ 708.295.3074. *Get Today's Price is available to all customers and can also be obtained by calling or coming into the dealership today. Purchase prices do not include tax, title, license and $179.81 doc fee, or Maintenance. Please verify all information. Contact Information: Continental Nissan, 5750 S. Lagrange Rd, Countryside, IL, 60525, Phone: (708) 352-9200, E-mail: dpecho@continentalnissan.com.
Continental Certification INCLUDED!!! 30 Days or 1000 miles of PROTECTION!!! Auto fans love the braking assist, stability control, traction control, anti-lock brakes, dual airbags, side air bag system, digital display, and airbag deactivation of this 2014 Chevrolet Malibu LT w/1LT. This sedan is one of the safest you could buy. It earned a crash test rating of 5 out of 5 stars. It has great mileage with 25 MPG in the city and 36 MPG on the highway. Rocking a suave black exterior and a jet black interior, this car is a great pick. Come see us today and see this one in person! At Continental Nissan We pride ourselves on our customer service. Have a quick look around, we are the TOP RATED Nissan Dealer in the state! We make our customers HAPPY!!! Call us TODAY @ 708.295.3074. *Get Today's Price is available to all customers and can also be obtained by calling or coming into the dealership today. Purchase prices do not include tax, title, license and $179.81 doc fee, or Maintenance. Please verify all information. Contact Information: Continental Nissan, 5750 S. Lagrange Rd, Countryside, IL, 60525, Phone: (708) 352-9200, E-mail: dpecho@continentalnissan.com. | 2019-04-24T18:05:38 | https://www.continentalhonda.com/used-cars-chicago-il?page=11 |
Click on any image to see the collection for the event.
If you want to download images you’ll need the pin number listed below set’s thumbnail image.
Higher resolution images and prints are also available for purchase.
Our galleries give you the opportunity to view, download, share on social media, and purchase photos from your event.
Downloads with Watermark are free.
To obtain a hi-res printable download without a watermark, click the BUY PHOTO button then click the digital link directly under the photo (see illustration). Most photos are printable up to 16x20. Make sure you write down your PIN before you enter the gallery. | 2019-04-25T14:33:55 | https://www.elliotshouse.com/events-and-photographs/ |
JB Kind will support our experienced and knowledgeable employees with training to ensure that we are able to provide you with a reliable, efficient and authoritative service when you need it.
We will respond to all written enquiries within two working days.
During office hours, we will endeavour to answer all calls within three rings. If your call is in out of office hours, an answer phone will take the details of your enquiry and you will receive a response the following working day.
Our comprehensive UK delivery service will deliver your order via our dedicated fleet of lorries and selectively chosen partners.
We would welcome any suggestions about improvements to JB Kind products or services. You can provide us with your comments by contacting [email protected] or 01283 554 197.
If you have a complaint, we would like the opportunity to address the problem with you. We will do everything we can to resolve your concerns as soon as possible. If we cannot resolve your complaint immediately and we need to investigate your complaint further, we will ask you to provide us with further information and we may ask if we can come and visit you to discuss the problem or assess any product concerns. Our Customer Services team can be contacted at [email protected] or on 01283 554 197.
JB Kind aims to provide high quality, innovative and competitively-priced products that comply with a wide range of industry, UK and European standards.
We will ensure our manufacturers undergo a vigorous programme of assessment, through ongoing audits to guarantee that they adhere to our stringent quality controls. This enables us to deliver the highest standard as well as compliance to our exacting specifications.
We will continue to have strong sustainability principles and only provide timber products from sustainable sources. We will also continue to support the FSC® (Forestry Stewardship Council) chain of custody certification scheme.
We will continue to make sure that all of our products are backed by industry leading accredited schemes. For example, we offer a range of British Woodworking Federation (BWF) CERTIFIRE products, as well accreditation to the PAS 24: Enhanced security scheme.
All of our products are guaranteed against defects in manufacture for a period of two years from the date of purchase.
We always pack our goods with care to ensure that every door is fully protected and reaches you in good condition.
If you would like this Customer Charter in a different format, please contact us at [email protected] or 01283 554 197 and we will be happy to accommodate your specific requirements.
Our dedication to meeting the highest standards for our customers is illustrated by our continuous achievement of the UK quality award, the ISO9001 accreditation. | 2019-04-25T04:08:05 | https://www.jbkind.com/about/documents-and-policies/customer-charter |
Are you in need of great value Garden Tidy Ups in Neasden London NW10?
Looking for an efficient yet affordable Garden Tidy Ups service for your outdoor area in 61a, London, NW10?
Choose our Garden Tidy Ups company in Neasden London NW10 and we will do all your gardening chores with ease. Our gardeners will provide you with a cost-effective Garden Tidy Ups service of outstanding quality.
From one-off landscaping services to regular lawn mowing in Neasden London NW10, we can offer you a wide variety of services. Contact our knowledgeable team over the phone or via email and we will give you a free no-obligation quote. It is easy to book our efficient Neasden London NW10 gardening services online – all you need to do is complete the form on our contact page. After you share your gardening requirements with our team and agree on the price for your job, our Garden Tidy Ups gardeners will show up at your address in Neasden London NW10 to finish the task. | 2019-04-23T02:07:23 | http://www.excellentgardeners.co.uk/garden-tidy-ups_neasden-nw10.html |
The Dean of Students or the Dean’s designee, in consultation with the Director of Campus Safety and/or Director of Residence Life, may authorize a search of a student's premise if there is reasonable cause to believe that a violation of college policy is occurring or has occurred.
Authorized personnel of Rhodes have the right to enter student rooms at any time for purposes of maintenance and repair, inspection of health and safety conditions, and investigation of violation of College regulations. Resident Assistants conduct routine checks of battery-powered room smoke detectors. At least once a semester a representative of the Residence Life Office and/or a representative of Physical Plant or Campus Safety will conduct safety, sanitation, and maintenance inspections. | 2019-04-24T22:37:59 | https://handbook.rhodes.edu/student-handbook/residence-hall-policies/room-searches-and-safety-inspections |
White fillings are one of the best ways to improve the health of your smile. Many of us have a mouthful of outdated fillings from the dark ages of dentistry. Dark, unattractive, mercury-silver fillings dot the mouths of millions of people who would otherwise have beautiful smiles. These old silver fillings downgrade the appearance and the strength of your teeth, and can commonly break or fracture the teeth, which might result in the need for future crowns, root canals, or possibly even extractions.
But today you can replace these old fillings with state-of-the-art, mercury-free, white fillings. These beautiful alternatives to silver fillings are matched perfectly to the color of your teeth, and because they are bonded in place, they can restore almost 100% of the original strength of your teeth. With white fillings the natural health and beauty of your teeth can be renewed. | 2019-04-26T06:22:32 | https://doclogan.com/dentist-ofallon-mo/restorative-dentistry/white-fillings/ |
If you are serving your perfect prospects, your business could flourish.
I’ve never been a big fan a general correspondence to large lists of prospective buyers. That’s like net fishing, throw out a net and whatever fish swims in, is good.
Well, booking great gigs requires much more finesse and discrimination. I like to focus like a laser beam, on exactly the right prospect for whatever I’m doing. That’s why I like to cast my net on one individual prospect at a time, but it has got to be the right prospect that enables me to catch multiple opportunities.
Translated, that means looking for gig opportunities within a niche market perfectly suited for your act.
In order to do that, you need to know who you are dealing with in much more depth than the name of the venue and whether it is along your tour route.
Here are 6 things to consider as you search to serve your perfect prospects.
Does the venue, business or organization serve an audience with whom you have a deep connection or affinity?
Does the venue, business or organization offer you multiple performance opportunities? Are there several options to perform in one community? Do they have multiple locations or chapters throughout a defined region, country or world-wide?
Before speaking with anyone from the organization, what can you learn about them from pre-call research that you may use to refine your introduction and pitch?
How well do you understand their audience before making any inquiries. If you did additional research, could that help make your pitch even better? Would it be worth your time?
Would you be willing to spend a bit of extra time and effort developing a high dollar prospect if it meant that it would open multiple performance opportunities?
Does this require a shift in how you do things now? Would it eventually be more profitable over the long-term, if you really understood your prospects and sought to serve only those that fit well with who you are and what you do—to serve your perfect prospects?
These questions really require you to know yourself, your art or act, where you would be best presented and to what kind of audience. Understand who your best, most appreciative, most attentive audience members might be. Eliminate all those venues, businesses and organizations that just don’t fit. Start making inquiries to the perfect performance prospect.
Does it take a bit of work? Perhaps. But, consider the time, effort and money spent on blindly sending thousands of emails out to directory lists or purchased databases. Here you are hoping that your target list might, might hit someone’s fancy and spark a response. I’d opt for focused, strategic, targeted niche markets every time. I hope this brings you some new focus to your booking strategies as well.
Let me know if this strikes a chord with you and how you will begin putting this into play in your bookings.
As usual, a great Biz Booster, a great reminder and confirmation of the approach that I am using, thanks to you. | 2019-04-24T02:42:28 | https://performingbiz.com/serving-your-perfect-prospects/ |
Set Of Three French Art Pendant Light By Deco Lights Nz published on light. which is part of the light collection. It’s full resolution is 768x1152 Pixels. | 2019-04-19T06:43:51 | http://dailycarepak.info/art-deco-pendant-light/set-of-three-french-art-pendant-light-by-deco-lights-nz/ |
There were many happy updates over the course of this long weekend, for which I am very grateful. The big one is that my grandmother is home from the hospital and doing well. She's still pretty uncomfortable, but that's to be expected. When she came limping in the door, my extremely frail grandfather just lit up and stood to greet her. Then they shuffled their way over to kiss each other say "I missed you, Honey!" It was too precious for words. They'll be married for 64 years in November.
The other big one is that it seems (for the time being, at least) the furlough threat has passed. It's possible there could be an appeal, but for the foreseeable future, we're safe in this regard, and for that I am unendingly grateful.
My car is still hot, but hey, you can't win 'em all.
On Friday after work (after receiving the furlough news...), I treated myself to a few new skirts at Old Navy since they are quickly becoming a staple of my summer wardrobe and I have so very few of them. As I've mentioned, it's really hard to find skirts that I consider to be an appropriate length. I never used to wear skirts much, but now I'm a total convert. They're *so* cool for the summer, especially with the car situation. Love them. I have 2 skirts from Target, and one long black skirt that I've had for so long I can't even remember when I obtained it. I needed a bit of a bump up in the skirt department.
At any rate, I wore the church skirt to Mass on Sunday, and as expected, it performed up to task. Long skirts have the added benefit of staying firmly put and not doing anything scary when Henry inevitably messes with them and tries to hide under them. We don't want me being permanently uninvited from my parish.
Every parent has their own set of rules when it comes to managing unruly children during Mass. I have mine, but I don't begin to cast judgment on others who may see things differently. Wrangling children during Mass is *hard*, and as long as the kids aren't doing anything completely objectionable, I keep my opinions to myself.
Stage 1 - Infant. Lots of holding, soothing and rocking. If baby cries, take to narthex.
Stage 2 - Ages 1 to 2. This, my friends, is when things get hairy. So, so much squirming. And talking and crying. LOUD talking. For a month or two, I didn't bring Henry to Mass at this age. It was just unrealistic to expect him to keep quiet for an hour. When I did bring him, I did employ *neat* snacks such as a small container of dry Cheerios or those little packaged fruit jelly things, and 1 sippy cup (the non-spill kind) of milk. I was fastidious in making sure that we didn't make crumbs. I know some parents don't do this, and to each their own. I know that children can easily go an hour without eating, it's just all about noise control. Trying to keep a 1 year old quiet for a full hour on your own could make a grown man cry, trust me, so I saw it as justifiable.
Stage 3 - Ages 2 to 3. Pretty much a continuation of above with possibility of full scale tantrum now added in. See Stage 2, supra. Good times.
Stage 4 - Ages 3 to 4. Some improvement here. No more sippy cups and I gradually phased out the snack. Books are key.
Stage 5 - Ages 4 to 5. I still bring books with us every week, including his little Bible, but I do tote along some secular books like the Look and Finds he likes or a super hero book. I've been noticing that he doesn't look at them as much anymore, and this brings me to what Greg and Jennifer were talking about. As your kids get older, how do we engage them and get them to participate at Mass?
This past week, I had him look at my Missal a bit, and tried to whisper explanations in his ear as things were happening. That seemed to go over fairly well. We do always sit near the front now, which does appear to engage him more. I'm thinking about Magnifikid, but he can't read yet, so I'm not sure the time is quite right for that. Suggestions?
For my church, the roll over skirt would be a welcome sight of modesty. Believe me, I see a lot worse all the time.
As for long skirts that aren't expensive, try the thrift store. Long skirts are usually stocked in the winter time. And for long skirts that are thinner for the summer, they are harder to find and much more expensive. I just go to the thrift stores. It's good for the environment anyway.
You know, that's an excellent point about the thrift store! We've gotten some furniture from our local thrift stores and have loved it. End tables, that sort of thing, good stuff :) Thanks! | 2019-04-24T19:49:52 | http://www.lifeofacatholiclibrarian.com/2010/06/some-happy-updates-and-mass-with.html |
Systemic hypertension often accompanies chronic renal failure and can accelerate its progression to end-stage renal disease (ESRD). Adjunctive moxonidine appeared to have benefits versus adjunctive nitrendipine, in a randomised double-blind six-month trial in hypertensive patients with advanced renal failure. To understand the longer term effects and costs of moxonidine, a decision analytic model was developed and a cost-effectiveness analysis performed.
A Markov model was used to extrapolate results from the trial over three years. All patients started in a non-ESRD state. After each cycle, patients with a glomerular filtration rate below 15 ml/min had progressed to an ESRD state.
The cost-effectiveness analysis was based on the Dutch healthcare perspective. The main outcome measure was incremental cost per life-year gained. The percentage of patients progressing to ESRD and cumulative costs were also compared after three years. In the base case analysis, all patients with ESRD received dialysis.
The model predicted that after three years, 38.9% (95%CI 31.8–45.8) of patients treated with nitrendipine progressed to ESRD compared to 7.5% (95%CI 3.5–12.7) of patients treated with moxonidine. Treatment with standard antihypertensive therapy and adjunctive moxonidine was predicted to reduce the number of ESRD cases by 81% over three years compared to adjunctive nitrendipine.
The cumulative costs per patient were significantly lower in the moxonidine group €9,858 (95% CI 5,501–16,174) than in the nitrendipine group €37,472 (95% CI 27,957–49,478).
The model showed moxonidine to be dominant compared to nitrendipine, increasing life-years lived by 0.044 (95%CI 0.020–0.070) years and at a cost-saving of €27,615 (95%CI 16,894–39,583) per patient.
Probabilistic analyses confirmed that the moxonidine strategy was dominant over nitrendipine in over 98.9% of cases. The cumulative 3-year costs and LYL continued to favour the moxonidine strategy in all sensitivity analyses performed.
Treatment with standard antihypertensive therapy and adjunctive moxonidine in hypertensive patients with advanced renal failure was predicted to reduce the number of new ESRD cases over three years compared to adjunctive nitrendipine. The model showed that adjunctive moxonidine could increase life-years lived and provide long term cost savings.
End-stage renal disease (ESRD) is a disorder that occurs worldwide and is associated with a high cost to society due to the need for dialysis or renal transplantation. In 1994, 7,340 patients in the Netherlands were receiving renal replacement therapy, incurring direct medical costs of NLG 584 million (262 million 1994 €) and indirect costs of NLG 3.5 million (1.6 million 1994 €). De Wit et al estimated that in 2003, there would be 11,500 patients receiving renal replacement therapy at a cost to society of over NLG 900 million (405 million 1994 €) .
Systemic hypertension frequently accompanies chronic renal failure (CRF) and is a strong risk factor for the development of ESRD . Thus current drugs target systemic hypertension in addition to proteinuria in an attempt to slow the progression of renal disease . Angiotensin-converting enzyme inhibitors (ACEI) or angiotensin receptor blockers (ARB) are the treatment of choice for hypertensive patients with CRF, with the addition of diuretics for inadequate blood pressure control. Patients often require athird drug to control hypertension effectively [4, 5].
Moxonidine may be a good candidate for adjunctive treatment to standard therapy as it interferes with the sympathetic nervous system overactivity which may contribute to hypertension in CRF patients [6–9].
The short term benefits of adjunctive treatment with moxonidine on top of standard antihypertensive therapy have been shown, versus adjunctive nitrendipine, in a single randomised double-blind 24-week trial in hypertensive patients with advanced renal failure. Most patients received standard therapy of ACEI or ARB plus diuretics. Although this study was primarily a safety and tolerability study, a significant difference was seen in creatinine clearance decline between the moxonidine group and the comparator group after 24 weeks of treatment . This was the only study found comparing moxonidine to nitrendipine in a review of the literature to date. Creatinine clearance is an indicator of the glomerular filtration rate of the kidneys. A reduction in creatinine clearance levels indicates a decline in kidney function. The trial measured baseline proteinuria in around 60% of patients in each group and found levels were similar across both groups. But proteinuria levels were not available in 40% of patients and therefore it is not possible to know this impact on the overall trial outcomes, as proteinuria is a risk factor for renal disease progression. Therefore a major assumption of our study was that the differences in creatinine clearance decline were not caused by other risk factors (such as underlying disease or proteinuria level). Based on this assumption, it was hypothesised that adjunctive moxonidine in hypertensive patients with renal failure may contribute to decreasing the burden of ESRD.
In order to understand the effects of moxonidine on renal progression and on costs over a longer period, a decision analytic model was developed and a cost-effectiveness analysis was performed on the basis of the Dutch healthcare setting.
Creatinine clearance measures from the trial were not measured directly, but were obtained using the Cockcroft & Gault equation, and assumed to equal GFR measures in the model. The Cockcroft-Gault equation is frequently used for estimating GFR in adults. Although it was originally developed for estimating creatinine clearance, it has been widely tested as a good predictor of GFR . Age, gender, and body weight are used to correct for the differences in muscle mass, and hence creatinine generation rate.
Transition probabilities for moving from the NESRD (GFR > 15 ml/min) to ESRD (GFR < 15 ml/min) state were based on extrapolations of the trial results. The average GFR decline over the three year time horizon was assumed to be linear. A linear progression was judged to be acceptable in these very renally-impaired patients. The mean decline in GFR over the trial period – from baseline (visit 2) to week 24 (visit 9) – was 0.7 ml/min for the moxonidine group and 1.8 ml/min for the nitrendipine group. This average decline over a six-month period was applied to each six-month period in the model, with accompanying standard deviations (SD) keeping the ratio of mean/SD constant throughout the cycles. Based on the given and estimated means and SD, the percentage of patients with ESRD (GFR < 15 ml/min) was then calculated for each six-month period using the gamma distribution (parameters Moxonidine α = 1.445, β = 83.555, Nitrendipine: α = 12.403, β = 66.597). The gamma distribution was found to best describe the trial data compared to the normal or lognormal distribution (skewed to the right with no negative values) [18, 19]. A consequence of this method is that there were some patients with ESRD at baseline in both groups, and these patients were not receiving dialysis or transplants. Therefore only new cases of ESRD were used to derive transition probabilities for the model.
†Based on data from Vonend et al 2003.
‡Based on data from ERA EDTA Annual report 2002.
The difference in GFR decline found in the trial was not caused by differences in other risk factors for decline in renal function (like underlying disease or proteinuria level).
The Cockroft and Gault formula is acceptable to calculate the GFR levels for the population of the study.
Extrapolating the average decline found over the initial 6 months will not overestimate the decline in the following periods.
The gamma distribution is best to estimate the percentage of patients with a GFR < 15.
All patients received dialysis during the ESRD state.
From the ERSD state patients could stay in this state or enter the death state but they could not go back to the NESRD state.
Breakdown of costs (€) by health state.
† z-index: Cost of antihypertensives based on patient usage: 89% on ACE I (ddd enalapril 25 mg) and 11% on ARB (ddd losartan 50 mg), and 35.6% on beta blocker (ddd atenolol 75 mg) and 27.4% on alpha blocker (ddd doxazosin 4 mg). Costs of diuretics were assumed to be included in NESRD costs based on manuscript van Hout et al.
All cost data were expressed in Euros; USD costs were converted to Euro by purchasing power parities . All costs were transformed to 2004 prices by means of price indexes from the Dutch "Manual for cost calculations: methods and recommend prices for economic evaluations in health care." All drug costs were based on public prices (ex VAT) from the Dutch Z-index. The daily defined dosage was used to calculate the drug price per cycle.
Generally Markov models assume transitions from one health state to the next occur at the end of the cycle, however in reality this transition can occur at any point during the cycle, therefore a half-cycle correction was incorporated.
The cost-effectiveness analysis was based on the Dutch healthcare perspective, with a time horizon of three years from the start of treatment. The main outcome measure was the incremental cost per life-year gained. The percentage of patients with ESRD and the cumulative costs were also compared at three years. A discount rate of 4% on costs and 1.5% on life-years per annum was applied, as recommended by the Dutch guidelines .
The cost-effectiveness analysis was performed for a hypothetical cohort of patients similar to the patients in the trial: adult patients with advanced renal failure (GFR < 30 ml/min) and hypertension (DBP 80–100). Patients were already receiving treatment with loop diuretics and ACEI or ARB, and were given moxonidine (0.3 mg/day) or nitrendipine (20 mg/day). Patient exclusion criteria included presence of sick sinus syndrome, higher degree sino-atrial or atrioventricular block, bradycardia, malignant arrhythmia, heart failure of New York Heart Association stage III or IV, severe chronic ischemic heart disease, symptomatic cerebrovascular disease, unstable angina pectoris, severe hepatic disease, history of malignant disease within two years, pregnancy or lactation, history of depression, drug abuse or alcoholism.
Both analyses were performed with a 'living donor to cadaver donor' ratio of 34% to 66% .
The source data are characterised by uncertainty. A probabilistic sensitivity analysis was performed to quantify the uncertainty in the model outcomes. A random value was repeatedly sampled from distributions reflecting the uncertainty level of the input source data, plugged into the model, and then the outcome of the model was calculated. Each model outcome is presented with a point estimate along with uncertainty reflected by the 2.5 th and 97.5th percentile of the uncertainty distribution. Uncertainty in the transition probabilities from NESRD to ESRD were based on the trial and expressed with beta distributions (alpha and beta determined from the standard error). Uncertainty in resource data were expressed with triangular distributions, with the low and high values as 80% and 120% of the expected value. Probabilistic sensitivity analysis was performed for both the base case scenario and for scenario analyses.
The model predicted that after three years, 38.9% (95%CI 31.8–45.8) of patients treated with nitrendipine progressed to ESRD compared to only 7.5% (95%CI 3.5–12.7) of patients treated with moxonidine. Thus suggesting that standard treatment with adjunctive moxonidine could prevent 31.4% of new cases of ESRD compared to adjunctive nitrendipine (see Figure 2.), or reduce the number of ESRD cases by 81%.
Cumulative percent of patients with ESRD after 3 years.
The proportion of survivors was 98.6% in the moxonidine group after three years compared to 93.9% in the nitrendipine group. Thus the model suggests that patients treated with moxonidine could gain on average 0.044 (95%CI 0.020–0.070) life-years compared to patients on nitrendipine (discounted life-years were 2.950 (95%CI 2.937–2.959) versus 2.907 (95%CI 2.882–2.927).
After three years, the cumulative costs per patient appeared to be lower in the moxonidine group (€9,858 with 95% CI 5,501–16,174) than in the nitrendipine group (€37,472 with 95% CI 27,957–49,478) (see Figure 3). Thus moxonidine provided a cost saving of €27,615 (95%CI 16,894–39,583).
Expected 3-year cumulative cost per patient.
The model calculated that moxonidine treatment provided a cost saving of €27,615 (95%CI 16,894–39,583) and extra life-years gained of 0.044 (with 95% CI 0.020–0.070) years compared to nitrendipine treatment, thus moxonidine was the dominant strategy. (Table 3) Moxonidine is said to be dominant because it could provide a more effective treatment strategy and for less cost. Probabilistic sensitivity analyses confirmed that the moxonidine strategy was dominant over nitrendipine in over 98.9% of cases.
Thus if 100 patients were given each treatment over three years, the model predicts that after three years 7 patients on moxonidine versus 39 on nitrendipine will have progressed to ESRD, and 1 patient will have died in the moxonidine arm versus 6 in the nitrendipine arm. The cost of treating the moxonidine group would be €985,800 versus €3,747,200 for the nitrendipine group, due to the high cost of treating patients who have progressed to ESRD.
The proportion of ESRD patients receiving dialysis or transplantations was varied in sensitivity analyses. The model showed that when 64% of patients received dialysis (and 34% received transplantations), the cumulative 3-year costs remained lower with moxonidine versus nitrendipine (€8,496 (95% CI 4,920–13,367) versus €31,035 (95% CI 23,618–40,163) respectively), and life-years remained higher in the moxonidine arm (2.954 (95% CI 2.944–2.960) versus 2.923 (95% CI 2.907–2.936) respectively). When 50% of patients received dialysis (and 50% transplantation), the cumulative 3-year costs and LYL continued to favour the moxonidine strategy versus nitrendipine (€7,953 (95% CI 4,603–12,546) and 2.955 (95%CI 2.946–2.960) for moxonidine versus €28,649 (95% CI 21,938–36,392) and 2.929 (95% CI 2.915–2.941) for nitrendipine).
When a 0% discount rate was applied to costs and effects the following results were found: Cumulative costs were €10,349 (95%CI 5,572–17,282) with moxonidine and €39,035 (95% CI 29,324–50,003) with nitrendipine, resulting in a cost saving of €28,686 (95% CI 17,772–41,347) with moxonidine. Life-years lived were 2.987 (95% CI 2.971–2.996) for moxonidine and 2.943 (95% CI 2.919–2.963) for nitrendipine, resulting in 0.044 (95% CI 0.019–0.070) life-years gained with moxonidine.
When the average GFR decline was assumed to decrease exponentially, the results still supported moxonidine over nitrendipine; all patients on nitrendipine had progressed to ESRD after 2 years versus 25% of patients on moxonidine (or 74% after 3 years). Thus moxonidine would provide 0.084 (95%CI 0.059–0.108) additional life-years at a cost saving of €48,364 (95%CI 37,966–59,198) after 3 years.
When Dutch all-cause mortality was incorporated to the NESRD arm, the life-years gained with moxonidine was 0.041 (95%CI -0.035–0.112) years at a cost saving of €27,252 (95%CI 16,652–38,854). Moxonidine was dominant in 90% of cases.
With this model, moxonidine treatment on top of standard therapy in severely renally-impaired patients appears to be cost-effective versus adjunctive nitrendipine, resulting in lower treatment costs (€27,615 lower (95%CI 16,894–39,583)) and a greater number of life-years lived 0.044 (with 95% CI 0.020–0.070) when the results of the six month trial are extrapolated over three years. Sensitivity analyses have shown that these results are robust. Thus given the assumptions of the model, we can conclude that moxonidine could delay progression to ESRD in a large number of patients, thereby reducing the numbers of patients requiring dialysis or transplants compared to standard treatment with adjunctive nitrendipine. Treatment with moxonidine could therefore contribute to reducing the economic burden of ESRD and allow patients to live longer in a non-ESRD state.
Data used in the model was taken from the only study available at the time of moxonidine versus nitrendipine, which was a six-month trial, in 171 patients, with proteinuria levels measured in 103 patients. In the trial, creatinine clearance was calculated using the Cockcroft & Gault equation. As creatinine clearance is the result of clearance due to GFR and secretion of creatinine in the tubules, the model assumed that both treatments had no effect on secretion, thus GFR was equated to creatinine clearance measures alone.
The difference in GFR decline in the trial was assumed not to be due to differences in risk factors for renal progression such as level of proteinuria like albuminuria. Data on albuminuria were only available for a subset of patients in the trial (52/89 moxonidine patients and 51/82 nitrendipine patients). These data showed no significant differences between groups, although mean and median albuminuria values were lower in the moxonidine group (1.3 ± 1.8; 0.8 versus 1.9 ± 2.1; 1.1 at baseline). A limitation of this study is that the missing data for the remaining patients may mean that the two groups were not well matched for albuminuria, a major prognostic factor for renal decline .
The average GFR decline over the three year time horizon was assumed to be linear. This is not uncommon in the literature [25–27]. The extrapolation of GFR values from the six month trial also implied that the decline in the first three months after starting treatment was not significantly different than the decline in the following periods, as is sometimes suggested in the literature . However some clinicians assume an exponential decline over time. If the decline is exponential, and disease progression occurs faster, the benefit of moxonidine will be even greater as it appears to delay progression compared to nitrendipine. The results of the scenario analysis show that all nitrendipine patients would have progressed to ESRD compared to 25% of moxonidine patients after two years.
The model only included direct costs. The addition of indirect costs would however be expected to increase the benefit seen with moxonidine, as patients remain in a better state of health for longer and are therefore able to be more productive.
Patients with ESRD are presumed to have much worse quality of life than patients at earlier stages of the disease. Utility values found in the literature report measures of 0.41 for patients on kidney dialysis compared to 0.60 for patients with chronic renal failure . A higher utility value is associated with a better state of health. As such, a cost-utility analysis would be expected to produce even better results for moxonidine compared to standard treatment with nitrendipine, as patients treated with moxonidine remained in a non-ESRD state for longer.
Adjunctive treatment with moxonidine was assumed to have a renoprotective effect occurring independently of blood pressure control in the six month trial. This effect may be supported by the results of a recent study in which moxonidine was the only factor that significantly reduced the risk of a decrease of 50% or more in creatinine clearance rate, or the need for dialysis, or death, in patients following renal transplant. The relative risk reduction due to moxonidine was 0.3 (95% CI 0.1 – 0.6) in the multivariate analysis . Results of a small study in the Netherlands may also support the benefits of adjunctive moxonidine in chronic renal failure. In this study, moxonidine normalised sympathetic hyperactivity, which plays a role in renal hypertension, in patients on chronic eprosartan treatment .
The model extrapolated results from a 6-month trial over three years. Treatment with standard antihypertensive therapy (ACE inhibitor or ARB and loop diuretics) and adjunctive moxonidine in hypertensive patients with advanced renal failure was predicted to reduce the number of ESRD cases by 81% over three years compared to adjunctive nitrendipine. The model showed moxonidine to be dominant compared to nitrendipine, increasing life-years lived by 0.044 (95%CI 0.020–0.070) years and at a cost-saving of €27,615 (95%CI 16,894–39,583) per patient.
This study was sponsored by Solvay Pharmaceuticals GmbH, Hannover, Germany.
KL, YZ and DB contributed to the design of the study, data collection and analysis. KL and WG contributed to the drafting and reviewing of the manuscript. All authors read and approved the final manuscript. | 2019-04-26T05:39:24 | https://bmcnephrol.biomedcentral.com/articles/10.1186/1471-2369-8-9 |
I am by no means gifted in the gastronomy department, and my husband is a wizard in the kitchen, so I’m the backup chef my my house. Being a full time working mom doesn’t help in the time department either. That being said, those times when I decide to cook, I try to step up my game and go all out. Cooking is so thing I want to get even better at, and I really do love the process once I’ve started.
1. I love goat cheese.
2. You can prep these well in advance of any event and pop in the fridge – then just stick in the oven and boom, you are done.
3. I think anything with an herb accoutrement is particularly stunning!
And yes, this is the opposite of my juicing post, and I don’t care, it’s ok to indulge sometimes!
3. Unroll filo sheets (approximately 3 layers thick) and cut in half both horizontally and vertically, making 4 rectangular squares measuring approximately 5-6” long, laying them on a wooden cutting board.
5. Sprinkle thyme leaves along the left side of each pastry rectangle and fold it over to cover.
13. This dish is best when made just before serving; however, you can prepare all cigars ahead of time and then just pop them in the oven to look like a pro.
This is beautiful and appealing and I am going to make it! | 2019-04-23T12:05:08 | https://proseccoandpalmtrees.com/2016/09/09/goat-cheese-cigars-with-honey-and-thyme/?shared=email&msg=fail |
Mountian Country blends you into the high-country environment. Cover your neck, face, and head for maximum stealth on your next hunt.
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I’m going to tell you, these fit tight in the turkey woods. They are breathable and adjustable and just a great put together product. Kudo’s to HooRag for bringing this offering to the outdoorsman.
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An iron oxide mineral found in basalt. The magnetic field of the magnetite always aligns with Earth's magnetic field as molten basalt cools to solid form and makes a permanent record of the direction of Earth's magnetic field when the rock formed.
Most of the iron ore in the world is mined from Precambrian sedimentary rocks, the largest l ead-zinc-silver and copper deposits occur in sedimentary rocks (mostly Precambrian, especially Proterozoic), and the largest gold and uranium deposits also are located in sedimentary rocks as well (Archean to Proterozoic in age).
Skarn, in geology, metamorphic zone developed in the contact area around igneous rock intrusions when carbonate sedimentary rocks are invaded by large amounts of silicon, aluminum, iron, and magnesium.The minerals commonly present in a skarn include iron oxides, calc-silicates (wollastonite, diopside, forsterite), andradite and grossularite garnet, epidote, and calcite.
Consequently open sea navigation, commerce and warfare are to a great degree part of magnetite's legacy. A relatively common, black, metallic mineral, magnetite is also one of modern society's most important iron ores, occurring in a variety of igneous rocks, pegmatites, contact metamorphic rocks and hydrothermal veins.
A relatively common, black, metallic mineral, magnetite is also one of modern society's most important iron ores, occurring in a variety of igneous rocks, pegmatites, contact metamorphic rocks and hydrothermal veins.
Find iron ore from a vast selection of Rocks and Fossils. Get great deals on eBay!
Epidote is common in medium-grade metamorphic rocks as well as late-stage igneous rocks such as pegmatites. It ranges in color from yellow-green to green-black to black, depending on its iron content. Epidote is occasionally used as a gemstone.
Metamorphic Gemstones & Minerals. ... In rocks, scheelite may appear as crystals like two pyramids connected at its bases, or pseudo-octahedral, or having table-like faces, with detectable p . ... Hematite: Hematite is considered the most important Iron Ore mineral. Its crystals appear as reasonably thick.
· Economic Significance of Igneous Rocks. Since magma is the chief source of metal ores, many of them are associated with igneous rocks. The minerals of great economic value found in igneous rocks are magnetic iron, nickel, copper, lead, zinc, chromite, manganese, gold, diamond and platinum.
The igneous and metamorphic rocks, with their wealth of copper, silver, and iron ore, crop out to make the wild and picturesque scenery and the gorges of Keweenaw, Houghton, Marquette, Dickinson, Baraga, Iron, Ontonagon and Gogebic counties as well as the highest peaks in the State-the Huron and Porcupine mountains.
Iron Ore: Sedimentary Rock - Pictures, Definition & More. Iron ore is a chemical sedimentary rock that people have used as an important source of metal.
Pyrite occurs in large deposits in contact metamorphic rocks. Deposits of copper-bearing pyrite are widely distributed and often of great size. They usually occur in or near the contact of eruptive rocks with schists or slates. Pyrite weathers rapidly to hydrated iron oxide, goethite, or limonite; pseudomorphs of goethite after pyrite are common.
Iron-rich rocks are common worldwide, but ore-grade commercial mining operations are dominated by the countries listed in the table aside. The major constraint to economics for iron ore deposits is not necessarily the grade or size of the deposits, because it is not particularly hard to geologically prove enough tonnage of the rocks exist.
Sedimentary Rock Banded Iron Formation. ... Leslie Hale, the Smithsonian's rock and ore collections manager at the Smithsonian National Museum of Natural History, tells people that she is a "rock librarian." ... Metamorphic Rock Folded Marble. Metamorphic Rock Quartzite Metamorphic Rock Quartzite. Related Media . Plate Tectonics. TAGS.
Skarn is an old Swedish mining term originally used to describe a type of silicate gangue, or waste rock, associated with iron-ore bearing sulfide deposits apparently replacing Palaeoproterozoic age limestones in Sweden's Persberg mining district. Petrology. Skarns are composed of calcium-iron-magnesium-manganese-aluminum silicate minerals.
The deposits of iron ore which occur as rocks, interstratified or associated with sedimentary beds, have originated through complex processes, sometimes wholly, sometimes partly, of a purely chemical nature and usually more or less influenced by the agencies of organic life.
Bornite—"Peacock ore" copper mineral tarnishes a crazy blue-green. Cassiterite—Ancient and principal ore of tin. Chalcopyrite—Foremost ore of copper. Chlorite—The green mineral of many metamorphic rocks. Corundum—Natural alumina, sometimes known as sapphire and ruby. Epidote—Metamorphic mineral of a pistachio/avocado green color.
Slate (Metamorphic Rock) and Iron Ore Shale (Sedimentary Rock), Marquette, Michigan, USA Photographic Print by Ken Lucas. Find art you love and shop high-quality art prints, photographs, framed artworks and posters at Art.com. satisfaction guaranteed. | 2019-04-20T22:21:06 | https://www.rwsitalia.it/raw_path/metamorphic_rock_iron_ore_35172_19 |
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Quotes In Spanish About Love Prepossessing Cute Quotes In Spanish About Love picture is in category Quotes that can use for individual and noncommercial purpose because All trademarks referenced here in are the properties of their respective owners. You can browse other picture of Quotes In Spanish About Love Prepossessing Cute Quotes In Spanish About Love in our galleries below. If you want to see other picture, you can browse our other category.
Quotes In Spanish About Love Prepossessing Cute Quotes In Spanish About Love was posted in August 4 2018 at 8:00 am and has been seen by 51 users. If you want to view image in full size just click image on gallery or click "View Image" at the bottom of the image. | 2019-04-24T06:43:56 | https://tamilkalanjiyam.in/quotes-in-spanish-about-love/quotes-in-spanish-about-love-prepossessing-cute-quotes-in-spanish-about-love |
Cable providers today are under more pressure than ever to offer a gigabit experience to enterprise and residential customers. Recent updates with DOCSIS 3.1 have dramatically increased downstream and upstream capacity to address these needs, however, emerging applications such as virtual reality and ultra-high definition content will demand even greater performance.
Alan Breznik, Cable/Video Practice Leader, of Light Reading met with JR Walden, CTO & SVP of Medicom Communications, and Incognito CTO, Pete Koat, to discuss the future of DOCSIS and what the next chapter will address. | 2019-04-18T10:15:25 | https://blog.incognito.com/the-future-of-docsis-light-reading-incognito-and-mediacom-discuss-whats-next-for-docsis/ |
Is it possible to move the raid card without losing the windows build? I want to use the bottom port on my mobo for a secondary vid card (not sli) but in order to do that I have to physically move the raid card with my windows install on it.
The OS is ready for a re-install so if it doesn't work it's no big deal but I'd like to know in advance so I can prepare for an unexpected format.
Yes it should be no problem at all. | 2019-04-24T08:07:51 | https://www.hardwarecanucks.com/forum/storage/25923-swaping-pci-e-raid-card-slots.html |
In the previous Kind and Benevolent Despot, Dutch and Arthur we are able to save Javier from the prison. In the next mission Hell Hath No Fury which is the continuation of Savagery Unleashed, the gang will now deal with the ongoing war on the island. To leave the island Dutch and Arthur will have to help Hercule in stopping the Fussar’s naval ship and his army of soldiers.
For Gold Medal you will have to prevent 4 boats from reaching the store, you will have to destroy the naval ships without missing any shot and complete the mission with 70% accuracy.
In the camp region, go in the fort and you will see Dutch discussing with the Rebel about the boat. But the rebel will tell you that you will have to help him in the war before they can get to the boat. Follow the gang to the top floor and you will see explosions. This will trigger the fight, you will be assisting the rebels. Shoot all the men who are approaching the fort, you will need around 50% accuracy for Gold Meal.
Next help the rebel to push cannon on the edge. In the cutscene, you will see an army of guards entering into the fort region. Dutch will plan to clear the men from the beach. Follow him, and start shooting the intruders. You will be in the outer region of the fort, be ready to activate Dead Eye. Keep following Dutch and kill the intruders.
Next, instruct Hercule and Dutch. Just approach them and press the key that is prompted on the screen to command them what to do next. From here you will need to stop the rowing boats. For Gold, you will need to stop 4 boats from reaching the shore. Look on both the sides, you can spot ample boats. After clearing the boat to follow Hercule and Dutch and help them.
After dealing with the boats march to the beach and take down the remaining soldiers. After killing them all in the cutscene Dutch will tell you to use the Cannon. Follow Hercule, once you reach the top in the cutscene he will tell you to use the cannon.
Move the Cannon towards the ship and then fire. For Gold, you will need to hit the ship without missing a shot. Aim a little above the ship and your cannon shots will land on the ship. After hitting it seven times the ship will be destroyed.
After sinking the ship Hercule will tell you about the boat, walk towards the beach for the ending cutscene. The next mission you can play is Paradise Mercifully Departed. This mission will begin instantly after you are done with Hell Hath No Fury. For similar guides, tips and updates on the game do have look on our Red Dead Redemption 2 Wiki guide. | 2019-04-26T02:26:26 | https://www.gamepur.com/guide/36617-red-dead-redemption-2-he-hath-no-fury-walkthrough.html |
View Full Version : Google -- New Color Schemes!
Are you tired of the glaring white background color for Google's search results pages?
I spend a lot of time searching the Web on Google, but white backgrounds on a computer screen is like staring at a huge light bulb -- white backgrounds actually make my eyes go bleary after a while, so "I'm mad as hell, and I'm not going to take it anymore." I've created nine Google search boxes. Each one delivers Google results pages in a different, integrated color scheme -- all except three of them having a very dark background color as the basis for the scheme.
On that page, I've also included some tips on how to set up your own Google color scheme.
* Color-customized results pages are limited to Web searches.
* You must have a Web site in order for Google to deliver color-customized results pages. | 2019-04-23T02:29:43 | http://www.webdevforums.com/archive/index.php/t-11530.html?s=9d30ad09cacc53cdd62ccd440dd37694 |
Seconds... as it is a BT test... where is the latency test? In general bluetooth audio and video is a bad idea in the main core of the buffering protocol.
I have a Sonos Connect and Bridge. Connect goes into my PS Audio Sprout Coax/DAC, and then to Paradigm speakers. The Sprout also does Bluetooth. I have used the Bluetooth and it works flawlessly. But my main sources of music are vinyl from my Rega RP3 TT and FLAC streaming from Deezer through the Sonos.
I have had the Sonos since 2011 and it is a brilliant device. | 2019-04-19T08:16:10 | https://www.guru3d.com/articles-summary/wavemaster-cube-mini-review.html |
Police have released an image of a man they want to trace after a woman was sexually assaulted in a county town.
The woman was subjected to a serious assault by two men in Scalford Road, Melton in the early hours of Sunday, May 14.
She has worked with detectives to create the image – known as an e-fit – of a man Leicestershire Police wants to speak to.
The attack took place between 1am and 2am as the woman was walking past Catherine Dalley House.
Police said she was approached by two men who sexually assaulted her.
Detective Constable Felicity James said: “We appreciate some time has passed since this offence is said to have taken place.
“However I would like to reassure people that we have been carrying out inquiries throughout this period and have only just completed the image with the woman concerned.
“Our inquiries have included a CCTV trawl and extensive house to house inquires.
“We have remained in regular contact with the victim throughout the investigation and it is only very recently she has felt able to provide us with a full statement and the image.
“If you know who this could be please come forward.
“We would ask people to remain vigilant when out in the early hours of the morning, and report any suspicious behaviour to the police. | 2019-04-20T06:22:46 | https://www.leicestermercury.co.uk/news/local-news/you-know-man-police-appeal-315914 |
Any time of the year is a good time to cuddle up on the couch and enjoy a spine-chilling horror flick. Whether your taste runs to psychological thrillers or old-fashioned slasher films, Netflix has something to satisfy.
The streaming platform has become one of the top sources for entertainment for people all over the country, and while the choices are almost endless, we’ve curated some of the very best scary movies on Netflix for your next movie night.
This is the film that spawned hundreds of memes and nearly as many in-depth reviews as to what those strange, unseen creatures could possibly be. Bird Box is a Netflix original that stars megawatt actors like Sandra Bullock, Sarah Paulson, and John Malkovich.
Based on a bestselling book, Bird Box doesn’t purport to tell the whole story behind the nationwide outbreak at the beginning of the film, but rather focuses on how it affects a small group of characters, and their journey to try and find a safe haven. Bird Box will keep you on the edge of your seat, biting your nails in suspense until the very last second.
Relive the terror on the creepiest night of the year. Grab your friends and re-watch #TheConjuring for #FridayThe13th.
A good, old-fashioned ghost story with something for everyone, The Conjuring is based on real-life events, a haunting that took place nearly fifty years ago. Patrick Wilson and Vera Farmiga, seasoned horror film veterans, play paranormal investigators Ed and Lorraine Warren, trying to discover why a vengeful spirit persists in terrorizing a family in their newly-purchased farmhouse.
The Conjuring doesn’t rely too heavily on jump scares or excessive gore but builds the suspense gradually. It spawned several hit sequels, but the sheer terror of the original hasn’t yet been matched.
A classic action film that scared many people out of the water for good, Jaws has it all – humor, excitement, an intriguing story, and a truly terrifying soundtrack.
Follow along as a monster great white shark stalks a peaceful vacation community, picking out victims at will – and of the men who resolve to end the shark’s reign of terror once and for all. Jaws was the film that put young director Steven Spielberg on the map and is considered to be the first great summer blockbuster. Plus, the use of practical effects and careful camera work means that every shot of the giant shark is a real stunner.
Discover M. Night Shyamalan’s masterpiece on Netflix today – The Sixth Sense is still every bit as creepy as the day it was first released in 1999.
Haley Joel Osment delivers a riveting performance as a haunted young boy who can’t escape his visions of the dead, and Bruce Willis excels as a troubled psychiatrist who resolves to help the boy deal with his demons. Whether or not you know the mind blowing twist at the end, The Sixth Sense holds up beautifully for repeat viewings, and, if anything, only seems to get creepier.
"A 21st century classic," declares the @chicagotribune – See #TheWitchMovie today!
What would any list of great Netflix horror films be without the stunningly-filmed 2015 film The Witch? Set in Puritan New England, the movie follows a homesteading family that finds themselves haunted by a witch who lives in the nearby forest.
Incredibly creepy, from the bone-chilling silence of the film’s soundtrack to the grey, barren cinematography, The Witch will live in your nightmares for days following. Plus, it features one of the most terrifying finales of any film of the past several decades – on all accounts, The Witch is a must-watch.
Keep checking with The Cheat Sheet for more best-of Netflix lists, including the best gangster shows on Netflix and the most binge-worthy Netflix original series. | 2019-04-18T12:16:52 | https://www.cheatsheet.com/entertainment/the-scariest-movies-on-netflix.html/ |
The residential care system is rapidly developing and plays an increasingly important role in care for the elderly in Beijing. A noticeable disparity in the accessibility to existing residential care facilities, however, is demonstrated in existing studies. The spatial optimization of residential care facility (RCF) locations is urgently needed to promote equal access to residential care resources among the elderly population.
A two-step floating catchment area method with an additional distance-decay function is adopted to measure accessibility to residential care facilities. The spatial optimization model is developed to maximize equity in accessibility by minimizing the total square difference between the accessibility score of each demand location and the weighted average accessibility score. The Particle Swarm Optimization (PSO) method is implemented for the solution.
The optimized RCF layouts improve equal spatial access to residential care resources with very low accessibility standard variation (0.0066). A relatively large number of beds (51% of the total beds) to be located in the suburban districts between the central and periphery districts of Beijing are optimized. A smaller number of beds to be located in the central and periphery districts (33% and 16% respectively) are optimized. The gaps between the existing and optimized layouts suggest that more RCF beds (5961 beds) are needed in suburban districts, while the RCF beds in some subdistricts located in the central and periphery districts are oversupplied (5253 and 1584 surplus beds respectively).
The optimized results correspond to the municipal special plan proposed by the Beijing government. The optimization objective of this study is different from traditional facility location optimization models, and the method is efficient in maximizing equal access to residential care facilities. This method can support knowledge-based policy-making and planning of residential care facilities.
The elderly population in China reached 178 million in 2010, accounting for 13.3 percent of its total population. The Chinese government implemented the one-child policy in the 1980s, which has accelerated the population aging process. Beijing, the capital of China, also faces the challenge of population aging, even with the massive influx of younger working age people taking place. The elderly population (aged 60 and over) was 1.7 million in 2000 in Beijing (12.5% of the total population), and it rapidly increased to 2.63 million (20.3% of the total population) in 2012 . The number of the elderly population is expected to be 4.15 million (30% of the total population) in 2025 . Care for the elderly population has becomes a critically important issue for the central government of China, the local government of Beijing and Chinese society.
The socio-cultural changes in contemporary China have meant new challenges for the traditional family care system for elderly people. A residential care system is rapidly developing and will play an increasingly important role in care for the elderly population in the future [3–7]. The Construction Plan of Social Elderly Care System (2011–2015) issued by the State Council of the People’s Republic of China advocated the development of an elderly care system that mainly depends on traditional family and community care, supplemented by residential care. The Beijing local government has issued its first municipal special plan for the residential care system, which aims to provide residential care services for four percent of the elderly population in Beijing by 2020 . There is still a large gap between this policy goal and the existing residential care resources in Beijing. The number of beds offered by RCFs was 69.3 thousand in 2013 . To reach the policy goal, another 10,000 beds need to be added per year to the existing stock of beds from 2014 to 2020.
To distribute public services equitably and efficiently are the primary goals of the government. Accessibility to RCFs, however, shows a noticeable disparity among the various regions in Beijing [11, 12], which reflects the irrational locations of RCFs. Therefore, the spatial optimization of RCFs locations is urgently needed to maximize equal access to RCFs for the elderly population living across Beijing.
Existing research on residential care has mainly focused on the development of residential care services [13–15], spatial distribution of RCFs [16, 17], characteristics of older people living in RCFs [4, 18], preference for RCFs , and access to RCFs [11, 12, 20]. Little attention, however, has been paid to spatial optimization of RCFs locations in the context of Beijing. Some studies have examined the optimization of other types of facilities (e.g., health care facility) locations [21–25]. The optimization objectives of the classic location-allocation models, however, mainly focus on efficiency rather than equity of facility locations [25, 26]. Wang and Tang propose a model to deal with equity of accessibility to facilities, which aims to minimize the disparity in accessibility .
This paper aims to develop a spatial optimization model for the locations of RCFs to maximize equal access in the context of Beijing. The optimized locations of RCFs demonstrates one way forward for knowledge-based planning of residential care resources in Beijing. Section Two of this paper introduces the measurement of accessibility to RCFs. Following that, a spatial optimization model is developed to consider accessibility. In Section Three, the Particle Swarm Optimization Approach (PSO) is introduced as a solution to the optimization problem. The results of the PSO approach are presented in Section Four and the implications for planning and policy are discussed in Section Five.
Access to facilities has various definitions. One of the popular definitions classifies access as either spatial access or aspatial access. Spatial access emphasizes the spatial separation between supply and demand as a barrier or a facilitator, while aspatial access stresses nongeographic barriers or facilitators . This study focuses on spatial accessibility of RCFs.
where A i is the accessibility at demand point i, S j is the capacity of supply at location j, D k is the demand (i.e. elderly population in this paper), d ij (d kj ) is the distance or travel time between i(k) and j, f is a general distance-decay function. Specifically, A i refers to the number of accessible RCF beds per elderly person of the demand point i.
With regard to the distance-decay function f, various forms (either discrete or continuous) can be taken. The 2SFCA, for example, takes a dichotomous form, that is, any travel time within a threshold is equally accessible and any travel time beyond the threshold is inaccessible. By contrast, the gravity-based index takes a power function form. There are several other forms in the existing literature .
where d ij is the distance or travel time between i and j, d0 is the threshold distance (i.e. the catchment size), and β is the distance-decay parameter.
As summarized by Peeters and Thomas, the distance-decay parameter β in existing studies lies between 0.9 and 2.29 . Wang and Zhang conducted a sensitive analysis on β, setting β as 1 or 2 respectively . The results show that 2 is better for measuring the accessibility of health care facilities [29, 30]. However, it is different for RCFs compared to other health care facilities. The service users of RCFs travel much less frequently than the service users of health care facilities. Therefore, the distance-decay for RCFs is weaker than for other health care facilities, especially for emergency medical services. That is to say, β value for RCFs should be smaller than for other health care facilities. Our previous study measuring spatial accessibility to RCFs in Beijing sets β as 1 . In this study, sensitivity analysis of the value of β will first be conducted, with various β values from 0.6 to 1.4.
The catchment size d0 differs among various facilities and regions. Cheng found the maximum travel time that the elderly population and their families prefer is 1 to 1.5 hours in Beijing . This study sets d0 as 1 hour.
The classic location-allocation models focus on the efficient layout of facilities, such as maximum coverage (the maximum covering location problem), minimum number of facilities (the location set covering problem), and minimum travel time from demand points to facilities (the p-median problem) [21–25].
where A i is the accessibility score calculated by formulas (1) and (2), a is the weighted average accessibility, S is the total supply and D is the total demand. This model is a non-linear programming problem, which is different from the traditional linear programming models.
There are 14 districts and 2 counties in Beijing (Figure 1). They are divided into four functional areas according to the Beijing Urban Master Plan (2004–2020). The Capital Core Functional Area includes Dongcheng and Xicheng Districts, and the Urban Functional Extension Area includes Chaoyang, Haidian, Fengtai and Shijingshan Districts. The central districts of Beijing include the six districts in these two functional areas. The suburban districts are mainly included in the Urban New Developing Area (5 districts), and the peripheral districts are mainly included in the Ecological Protection Area (3 districts and 2 counties).
The functional area of 14 districts and 2 counties of Beijing.
The elderly population data at the subdistrict level is from the 6th population census. In the census, there are 324 subdistrict administrative units (Streets within urban areas and villages or townships in suburban and peripheral districts). We take the 324 units as the demand locations and their elderly population as the measure of demand. The spatial distribution of the elderly population shows an uneven pattern, with a decreased elderly population outwards as the distance increases from the city center (Figure 2). Locations of the subdistrict level units are obtained from the centroids of their administrative boundaries by using ArcGIS software.
The spatial distribution of elderly population at the subdistrict level in Beijing in 2010.
The candidate facility locations are determined at the subdistrict level as suggested by the municipal special plan for the residential care system. We measure the travel time from the demand locations to the candidate facility locations based on the road network of Beijing in 2010. To improve the accuracy of travel time, we adopt the estimated driving speeds of the road network in Beijing . The speeds of four-level roads are set at 50, 40, 30 and 20 km/h respectively. The network analysis tool in ArcGIS is used to calculate the shortest travel time from each demand location to each candidate facility location.
The optimization model is a quadratic programming (QP) problem as shown in formulas 3 and 4. A complex transformation is necessary to prepare for the implementation of QP. QP is usually inefficient and time-consuming and it might not be feasible for large computational problems. Thus, the Particle Swarm Optimization Approach (PSO) is adopted as a solution to the limitations of QP.
The PSO is an optimization algorithm originally proposed by Kennedy and Eberhart , analogous to the foraging behavior of birds flocking together. The algorithm has been widely used in various fields . Notably, the PSO can be applied for solving location-allocation problems .
where ω is the inertia weight, c1 and c2 are acceleration constants, and r1 and r2 are random numbers between 0 and 1.
where A i and a are given by formulas (1) and (4), respectively.
Besides the fitness function adopted in this study, the PSO solution allows various fitness function forms, such as ordinary least square (OLS), minimizing the maximum absolute error, and minimizing the sum of the absolute deviations , which is an important advantage compared to the traditional nonlinear programming solution.
We calculated five optimization scenarios where β ranges from 0.6 to 1.4 to assess the sensitivity of our results. With each β value, the accessibility to RCFs is measured based on the actual distribution of RCFs in Beijing. Both the standard variations of actual and equalized accessibility to RCFs are calculated, and the ratio between them reflects the efficiency of optimization (Table 2). The larger a β value is, the larger the values of the standard variations of actual and equalized accessibility are. The reason is that larger β values imply people are only willing to accept a shorter travel distance to obtain service from RCFs. Larger β values, however, lead to smaller ratios between actual and equalized accessibility standard variation. The ratio reaches a high level of 3.72 when β is 0.6 and it decreases to 1.73 when β is 1.4. In the following sections, we will discuss the optimized result of the scenario setting β as 1.0, which was also adopted in our previous study .A relatively large number of beds (51% of the total) are optimally located in the suburban districts between the central and peripheral districts of Beijing (Figures 2, 3). A smaller number of beds (33% and 16% of the total) are optimally located in the central and peripheral districts respectively. By contrast, the distribution of the elderly population is different from the optimized distribution of residential care resources as shown in Figures 2 and 3. The percentage of the elderly population by district declines from the central districts outwards.
The spatial distribution of the optimized residential care resources at subdistrict level in Beijing.
The optimized results imply that more residential care resources (34,762 beds, 51% of the total) should be located in the suburban districts to maximize equitable accessibility for the elderly population in Beijing. The results confirm the municipal special plan for the residential care system. There are approximately 1.1 million older people (64% of the total) in the central districts, while the optimized number of beds is only 22,413 (33% of the total). By contrast, the elderly population and optimized number of beds are 0.4 million (25% of the total) and 34,762 (51% of the total) respectively in the suburban districts. The high proportion of demand in the central districts can be met by the residential care resources located in the suburban districts as the travel conditions are relatively convenient in the central districts. Meanwhile, the land resources are relatively more abundant in the suburban districts than in the central districts. RCFs in the peripheral districts mainly meet the demand of the local elderly population, where the elderly population is 0.2 million (11% of the total) and the optimized number of beds is 10,867 (16% of the total).
In the optimized scenario, two subdistricts provide more than 1,000 RCF beds. They are Changxingdian in Fengtai District and Dongxiaokou in Changping District with 1,125 and 1,013 beds respectively. There are 21 subdistricts providing more than 600 RCF beds, among which 6 are in Tongzhou District, 5 in Haidian District, 3 in Daxing District, 2 in Shunyi and Chaoyang Districts, and 1 in Fengtai, Fangshan and Changping Districts respectively. These subdistricts should be the main areas for the allocation of RCFs beds. By contrast, 29 subdistricts provides less than 10 RCF beds, among which 10 RCFs are in Dongcheng and Xicheng Districts, 5 are in Chaoyang District, 2 in Haidian District, and 1 in Haidian and Fengtai Districts. In reality, it would not make economic sense to allocate any beds in these subdistricts because of the small number of optimized RCF beds and the cost of building facilities for such small numbers of beds.
The optimized RCF bed numbers at the district level are shown in Table 3. Daxing, Tongzhou, Chaoyang, Haidian, Changping, Fangshan and Shunyi Districts have more than 5,000 RCF beds each and they are all located in suburban districts. These regions do not only need to meet the local demands for residential care services but also the demands from the central districts. Dongcheng and Xicheng Districts, which are in the central district, have only 489 RCF beds in total, in stark contrast to the large number of elderly people (270,786 in total) living in these areas. The peripheral districts of Beijing, including Yanqing, Pinggu, Miyun, Huairou and Mentougou Districts, however, mainly provide residential care services for the local elderly population.The optimized results greatly improve equal access to residential care resources. The optimized layouts have a very low accessibility standard variation (0.0066), which means that the inequality in accessibility of demand locations to RCFs is insignificant, while the actual accessibility standard variation (0.0207) is 3.1275 times that of the optimized results. As the goal of the optimization is to minimize the accessibility differences at the subdistrict level, we evaluated the results by using the optimized accessibility score divided by 0.04 (the weighted average accessibility, see formula (4)). Figure 4 shows the results of the evaluation of the comparison between the optimized accessibility scores and the weighted average accessibility at the subdistrict level. The results show that the score in most subdistricts is between 0.98 and 1.02, which is very close to the weighted average accessibility measure. The subdistricts with scores that are higher or lower than the weighted average accessibility score are relatively evenly distributed both in the central and peripheral districts, which imply that the effects of our optimized results are positive and reliable.
Spatial distribution of the optimized accessibility equity to RCFs.
As we mentioned at the beginning, the goal of the official special plan on the residential care system is set to provide residential care resources for four percent of the total elderly population. We estimated the demands based on this goal and compared the existing residential care resources with the optimized results at the subdistrict level. We calculated the differences between the optimal number and the actual number of RCF beds in each subdistrict (Figure 5). If the value is positive, more beds should be allocated in the subdistrict; otherwise, there are redundant beds that should be reallocated to other districts to achieve an optimal distribution of RCFs. The results provide suggestions for future allocation of RCF beds at the subdistrict level.
The gaps between optimal and actual number of RCF beds at the subdistrict level.
According to the policy goal that 4 percent of the elderly population will live in RCFs, 68,437 RCF beds are needed to meet the demands based on the elderly population in 2010. The existing number of RCF beds was 69,314 in 2013, which already meets the total demand for RCF beds in 2010. The optimization results show that more beds are needed in the suburban districts (5,961 beds). There are 30 subdistricts that need more than 400 new RCF beds: 6 in Tongzhou and Chaoyang, 5 in Daxing, 4 in Mentougou, 3 in Changping, and 1 in Fangshan, Fengtai, Shijingshan and Shunyi Districts respectively.
In some subdistricts located in the central and peripheral districts, the existing RCF beds, however, are redundant compared to the optimization results (5,253 and 1,584 beds respectively). The number of surplus beds is more than 400 in 26 subdistricts, which are located in 13 out of 16 districts (except Dongcheng, Huairou and Shunyi): 5 in Chaoyang, 3 in Changping and Haidian, and 1 or 2 subdistricts in the other districts. That is to say, the oversupply of RCF beds is dispersed in various districts rather than concentrated in a few districts. One of the important reasons for the oversupply of RCF beds in some subdistricts is that many of the beds are concentrated in relatively large RCFs (i.e., facilities with more than 500 beds) near to green spaces in the subdistricts.
This paper first measures the accessibility to RCFs at the subdistrict level in Beijing. The spatial optimization model is developed to maximize equal access to residential care resources by minimizing the total square difference between the accessibility score of each demand location and the weighted average accessibility measure. The standard variation of accessibility at each demand location is 0.0066 in our results. The optimal results show that more RCF beds (34,762 beds, 51% of the total) should be allocated to the suburban districts, and less in the central and periphery districts (22,413 and 11,262 beds, 33% and 16% of the total, respectively).
The results also show the gaps between the existing and optimal layouts, which suggest that RCF beds should be increased in the suburban districts (5,961 beds). The RCF beds in some subdistricts located in the central and peripheral districts, however, are oversupplied (5,253 and 1,584 beds respectively). The gaps imply that the existing large supply in some subdistricts seems irrational under the maximum equity objective. The oversupply in most subdistricts with large RCFs is considerable compared to the existing bed numbers. For example, the Shisanling Township in Changping District had 5,350 RCF beds in 2013. It was the subdistrict with the largest absolute number of beds among all the subdistricts, but the optimal number is only 329. The RCFs in 24 of the 30 subdistricts that have more than 600 RCF beds are oversupplied for more than half of the existing RCFs beds. More efforts, however, are needed to confirm whether the existing RCF clusters are irrational indeed. On-site investigations to find out if the occupancy rate of RCFs located in existing clusters is low would be helpful for confirming the over-supply suggested by the modeling results.
The Beijing Municipal Commission of Urban Planning and the Beijing Civil Affairs Bureau issued a special plan for the development of RCFs . It claimed that the new increases in RCFs should mainly be allocated in the suburban districts. According to the special plan, 39.8%, 40.8% and 19.4% of RCF beds will be located in central city, new towns and rural areas respectively. Considering that the new towns in the special plan refer to the urban areas of the suburban and periphery districts or counties, planned distribution of RCF beds is quite similar to the results of this study. The plan recommended enlarging existing RCFs or renovating other types of public facilities to make them into RCFs to maximize the potential capacity instead of building new ones in the central districts. New RCFs are planned in the outer region of the central districts to meet local demand. Relatively more new RCFs are planned for the suburban districts with the goal of providing residential care resources for the elderly population living in the central districts. The optimized results of this study correspond to the municipal special plan. The results of this study therefore confirm that the layout proposed will meet the equality in accessibility to RCFs criterion to a great extent.
The optimization objective in this study differs from the traditional optimization studies of facility locations. The former aims to maximize equality in accessibility to facilities by minimizing the disparity in accessibility of each demand location , while most of the existing studies aim to maximize the efficiency of the facility allocation. The formulations of the two types of optimization objectives are different. The traditional objectives usually take a linear form, but the maximum equality objective is nonlinear . Both types of optimization objectives are important and significant for the planning of facility locations.
The methods used in this paper also improve on the measurement of accessibility to facilities in optimization studies of facility locations. The traditional location-allocation models usually adopt a dichotomous distance-decay form, namely, accessibility to facilities is assumed to be homogeneous within a certain threshold distance and inaccessible beyond the threshold distance. Moreover, traditional models do not take the capacity of facilities and difference in demand at locations into account. To measure accessibility more accurately, this study takes a 2SFCA form with a distance-decay function.
This research is one of the first studies to apply the optimization model maximizing equity in accessibility to residential care facilities considering different utilization behaviors in residential care services and health care services. The PSO method is used rather than a traditional quadratic programming method to solve the location optimization problem, which is found to be more effective than the traditional method. We also compare the optimization results with the distribution of RCF beds proposed by the special plan. The results show that the government’s plan on RCFs will meet the equality in accessibility to RCFs criterion to a great extent.
There are some limitations to this study. First, the geographical and socio-economic factors of elderly people’s preferences for RCFs are not considered in the optimization model. Second, the most recent population census data are only available for 2010, and the smallest scale of census data is only available at the subdistrict level (the average number of elderly population in subdistricts is 5,268). The census data at a smaller geographical scale would improve the accuracy of our findings.
In the future, we will strive to obtain smaller-scale or predicted elderly population data for better optimization results. Moreover, various optimization objectives (both maximum equality and efficiency) will be adopted to compare optimization results and costs in various optimization scenarios. As a first step, the findings of the current research, however, offer support for knowledge-based policy-making and planning of residential care facilities in Beijing, as well as in other regions in China and developing countries, where there is still in a great shortage of facilities and services for the elderly population.
All the authors gratefully thank the reviewers and editor for their insightful and constructive comments. We also appreciate the suggestions on the research project from Professor Fahui Wang in the Department of Geography & Anthropology at Louisiana State University. The financial support is from the National Natural Science Foundation of China (Grant NO.41301164) and the Ministry of Education China (Project 985). Professor Mark Rosenberg is the Tier I Canada Research Chair in Development Studies.
ZT and YC contributed to the design and analysis of the study and writing of the manuscript. TD contributed on the design and analysis of the study and revising the manuscript. MWR contributed to drafting the manuscript and revising it critically. All authors read and approved the final manuscript. | 2019-04-23T06:33:51 | https://ij-healthgeographics.biomedcentral.com/articles/10.1186/1476-072X-13-33 |
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Runs on a very good speed with the help of booster pump.
Do not tips like other pool cleaners.
Designed with 4 wheels for smooth movement in the in-ground pool.
Cleans the pool between 1-3 hours.
Removing the debris is simple, just takes few seconds.
Very long cord, which be cut according to your requirement.
The long hose of Kreepy Krauly gets tangled which is a turn off.
Pentair LL505G Kreepy Krauly Legend is a superior product with new innovative mechanism. The big storage bag is very handy for filtering more amount of debris. It is convenient to open with twist and lock system. I think this pool cleaner is the only product which boasts of 99% of 5 star ratings. The superior functions along with excellent performance make it the number one choice. Only 1% of its users are not satisfied with it because of the long cord which needs to be cut according to the requirement. Otherwise, it can be installed in few simple steps written on the user manual.
Attractive price bracket with unlimited benefits induces people to buy it. Pentair Kreepy Krauly Legend is good if you have an in-ground pool in shape other than square or rectangular because it gets stuck in the corners. Hope, Pentair Company tries to do something for this issue. It will last for at least 5-6 years without giving major probs. Check out more pressure side pool cleaners in the US market. | 2019-04-25T21:14:22 | http://www.poolvacuumhq.com/pentair-legend-pool-cleaner/ |
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