pubid int32 1.29M 27.8M | question stringlengths 44 263 | context dict | llama_405_gt stringclasses 4
values |
|---|---|---|---|
26,607,040 | Does a short-term transition from a high-fat diet to a normal-fat diet before pregnancy exacerbate female mouse offspring obesity? | {
"contexts": [
"Recent findings have highlighted the detrimental influence of maternal overnutrition and obesity on fetal development and early life development. However, there are no evidence-based guidelines regarding the optimal strategy for dietary intervention before pregnancy.",
"We used a murine model... | yes |
17,559,382 | Does vascular targeting agent Oxi4503 inhibit tumor growth in a colorectal liver metastases model? | {
"contexts": [
"Oxi4503 is a potent vascular targeting agent belonging to the family of combretastatins. These agents produce an acute reduction in tumor blood flow leading to tumor necrosis. Despite evidence of its efficacy in certain malignancies, the effect on colorectal liver metastases remains largely unkno... | yes |
12,120,210 | Do antisense oligonucleotides specific to mutated K-ras genes inhibit invasiveness of human pancreatic cancer cell lines? | {
"contexts": [
"Point mutations of the K-ras gene are detected in > 90% of human pancreatic cancers and may play an important role in tumorigenesis. However, correlations between mutant K-ras and the invasive activity of the tumor have remained unclarified.",
"17-merphosphorothioate antisense oligonucleotide... | yes |
23,857,401 | Does eZH2 promote E2F-driven SCLC tumorigenesis through modulation of apoptosis and cell-cycle regulation? | {
"contexts": [
"Although enhancer of zeste homolog 2 (EZH2) has been associated with both non-small cell and small-cell lung cancers (SCLCs), current observations suggest different mechanisms of EZH2 activation and overexpression in these lung cancer types. Globally, SCLC kills 200,000 people yearly. New clinica... | yes |
16,289,645 | Does non-compliance with the re-excision guidelines for cutaneous melanoma in The Netherlands influence survival? | {
"contexts": [
"To evaluate causes and consequences of not adhering to the clinical practice guideline for cutaneous malignant melanoma.",
"We conducted a retrospective cohort study of the clinical records of 454 subjects whose pathological reports were obtained from a population-based cancer registry to ass... | no |
23,631,806 | Is upregulation of microRNA-224 associated with aggressive progression and poor prognosis in human cervical cancer? | {
"contexts": [
"Accumulating evidence for differential expression of microRNA-224 (miR-224) in various types of human cancer suggests that it may be play a crucial role in tumor biology. The previous microarray detection also shown that miR-224 was one of miRNAs with significant upregulation in cervical cancer t... | yes |
10,921,046 | Does [ Expression of vascular endothelial growth factor correlate with invasion and metastasis of hepatocellular carcinoma ]? | {
"contexts": [
"To study the relationship between the expression of vascular endothelial growth factor (VEGF) mRNA and invasion and metastasis of hepatocellular carcinoma (HCC), and explore new approaches to prevent and inhibit recurrence and metastasis of HCC.",
"Surgical samples of 43 patients with HCC wer... | yes |
9,627,275 | Does the platelet-activating factor antagonist BB-882 improve tissue oxygen extraction in endotoxic shock? | {
"contexts": [
"We investigated whether BB-882, a novel potent PAF antagonist, could influence systemic and pulmonary hemodynamics and oxygen extraction capabilities during an acute reduction in blood flow induced by cardiac tamponade after endotoxin challenge.",
"Twenty-one anesthetized, ventilated, and end... | no |
11,120,702 | Is suppression of endothelial nitric oxide production after withdrawal of statin treatment mediated by negative feedback regulation of rho GTPase gene transcription? | {
"contexts": [
"Statins improve endothelial function by upregulating endothelial nitric oxide (NO) production that is mediated by inhibiting the isoprenylation of rho GTPase. Withdrawal of statin treatment could suppress endothelial NO production and may impair vascular function.",
"To test this hypothesis, ... | yes |
18,713,926 | Does continuous low-dose ketamine improve the analgesic effects of fentanyl patient-controlled analgesia after cervical spine surgery? | {
"contexts": [
"The effects of fentanyl with ketamine for postoperative pain are unknown. We investigated the adjuvant effects of ketamine for fentanyl patient-controlled analgesia.",
"Cervical and lumbar spine surgery patients were divided into three groups: ketamine 1 mg/kg followed by 42 and 83 microg x k... | yes |
17,400,672 | Does atrial septostomy decrease sympathetic overactivity in pulmonary arterial hypertension? | {
"contexts": [
"We have reported previously that the sympathetic nervous system is activated in patients with pulmonary arterial hypertension (PAH), and that this is only partly explained by a decrease in arterial oxygenation. Possible causes for increased muscle sympathetic nerve activity (MSNA) in patients wit... | yes |
16,392,347 | Are bone mineral density and bone histomorphometry statistically related? | {
"contexts": [
"The aim of this study was to evaluate how closely analysis of bone quality performed using the bone mineral density (BMD) values obtained by quantitative computerized tomography (QCT) reflected the histologic bone density.",
"Eighteen patients requiring implant therapy underwent CT scanning. ... | yes |
16,761,418 | Is [ The role of progesterone in human early pregnancy mediated by insulin-like growth factors binding protein1-3 ]? | {
"contexts": [
"To determine whether the functional role of progesterone in human early pregnancy is mediated by progesterone receptor(PR) and insulin-like growth factor binding protein 1-3(IGFBP1-3).",
"Sample collection was conducted in accordance to the principle of informed content. Decidua and villi wer... | yes |
12,599,229 | Is caveolin-1 expression a predictor of recurrence-free survival in pT2N0 prostate carcinoma diagnosed in Japanese patients? | {
"contexts": [
"The authors previously identified elevated caveolin-1 expression in human prostate carcinoma and determined that caveolin-1 levels as detected by immunohistochemistry of radical prostatectomy specimens offered novel prognostic information. A higher incidence of caveolin-1 expression also was repo... | yes |
24,515,619 | Does ondansetron preloading with crystalloid infusion reduce maternal hypotension during cesarean delivery? | {
"contexts": [
"The aim of the article was to investigate the effect of ondansetron preloading with crystalloid infusion after spinal anesthesia during cesarean delivery.",
"A total of 66 parturient women scheduled for elective caesarean sections were randomly assigned to two groups. Five minutes before spin... | yes |
8,566,600 | Does vascular adhesion protein 1 mediate binding of T cells to human hepatic endothelium? | {
"contexts": [
"Molecules that regulate T-cell adhesion to hepatic endothelium and thereby recirculation of T cells to the liver are poorly understood. Because the adhesion molecule vascular adhesion protein-1 (VAP-1), which mediates lymphocyte binding to lymph node endothelium, is expressed on hepatic endotheli... | yes |
9,369,964 | Is chemotherapy a safe and effective initial therapy for infected malignant breast and chest wall ulcers? | {
"contexts": [
"Locally advanced breast cancers may form large, infected skin ulcers, which were traditionally treated with radiation therapy. Neoadjuvant chemotherapy is now standard treatment for locally advanced breast cancer.",
"The response of 33 patients with ulcerated breast cancer to primary chemothe... | yes |
23,106,849 | Does perinatal nicotine exposure induce asthma in second generation offspring? | {
"contexts": [
"By altering specific developmental signaling pathways that are necessary for fetal lung development, perinatal nicotine exposure affects lung growth and differentiation, resulting in the offsprings' predisposition to childhood asthma; peroxisome proliferator-activated receptor gamma (PPARγ) agoni... | yes |
24,163,176 | Does foliar abscisic acid content underlie genotypic variation in stomatal responsiveness after growth at high relative air humidity? | {
"contexts": [
"Stomata formed at high relative air humidity (RH) respond less to abscisic acid (ABA), an effect that varies widely between cultivars. This study tested the hypotheses that this genotypic variation in stomatal responsiveness originates from differential impairment in intermediates of the ABA sign... | yes |
18,422,954 | Do gaseous environments modify physiology in the brewing yeast Saccharomyces cerevisiae during batch alcoholic fermentation? | {
"contexts": [
"To investigate the impact of different gaseous atmospheres on different physiological parameters in the brewing yeast Saccharomyces cerevisiae BRAS291 during batch fermentation.",
"Yeasts were cultivated on a defined medium with a continuous sparging of hydrogen, helium and oxygen or without ... | yes |
24,318,194 | Are dominant-negative effects of KCNQ2 mutations associated with epileptic encephalopathy? | {
"contexts": [
"Mutations in KCNQ2 and KCNQ3, encoding the voltage-gated potassium channels KV 7.2 and KV 7.3, are known to cause benign familial neonatal seizures mainly by haploinsufficiency. Here, we set out to determine the disease mechanism of 7 de novo missense KCNQ2 mutations that were recently described ... | yes |
25,844,694 | Do early Head CT Findings Are Associated With Outcomes After Pediatric Out-of-Hospital Cardiac Arrest? | {
"contexts": [
"Head CT after out-of-hospital cardiac arrest is often obtained to evaluate intracranial pathology. Among children admitted to the PICU following pediatric out-of-hospital cardiac arrest, we hypothesized that loss of gray-white matter differentiation and basilar cistern and sulcal effacement are a... | yes |
11,558,810 | Does isopropyl unoprostone increase the activities of matrix metalloproteinases in cultured monkey ciliary muscle cells? | {
"contexts": [
"The mechanism by which the prostaglandin F2alpha-related antiglaucoma compound isopropyl unoprostone (referred to as unoprostone) reduces intraocular pressure is largely unknown. Another prostaglandin F2alpha-related compound, latanoprost, influences the activities of matrix metalloproteinases in... | yes |
26,579,878 | Does rapid skeletal muscle wasting predict worse survival in patients with liver cirrhosis? | {
"contexts": [
"Sarcopenia impairs the outcome of patients with liver cirrhosis independently of liver function reserves. The aim of this study was to investigate whether the rate of skeletal muscle wasting predicts mortality in cirrhotic patients.",
"This retrospective study evaluated 149 cirrhotic patients... | yes |
21,148,514 | Does swine outbreak of pandemic influenza A virus on a Canadian research farm support human-to-swine transmission? | {
"contexts": [
"Swine outbreaks of pandemic influenza A (pH1N1) suggest human introduction of the virus into herds. This study investigates a pH1N1 outbreak occurring on a swine research farm with 37 humans and 1300 swine in Alberta, Canada, from 12 June through 4 July 2009.",
"The staff was surveyed about s... | yes |
18,213,629 | Does promoter methylation correlate with reduced Smad4 expression in advanced prostate cancer? | {
"contexts": [
"Transforming growth factor-beta (TGF-beta) is a potent growth inhibitor in a wide range of cell types. A transducer of TGF-beta signaling known as Mothers against decapentaplegic homologue 4 (Smad4) is a known tumor suppressor found on chromosome 18q21.1 and is typically inactivated by deletion o... | yes |
25,378,635 | Is host fate rapidly determined by innate effector-microbial interactions during Acinetobacter baumannii bacteremia? | {
"contexts": [
"Acinetobacter baumannii is one of the most antibiotic-resistant pathogens. Defining mechanisms driving pathogenesis is critical to enable new therapeutic approaches.",
"We studied virulence differences across a diverse panel of A. baumannii clinical isolates during murine bacteremia to elucid... | yes |
27,534,591 | Are sexual health and quality of life impaired in hidradenitis suppurativa : a multicenter cross-sectional study? | {
"contexts": [
"Hidradenitis Suppurativa (HS) has a major impact on the quality of life (QoL). Although it has commonly been assumed that HS impairs sexual health, only a single case-control study has been performed on sexual functioning in a small group of HS patients.",
"the objective of this study was to ... | yes |
23,989,033 | Does relief of depression and pain improve daily functioning and quality of life in patients with major depressive disorder? | {
"contexts": [
"The objective of this study was to investigate the effects of depression relief and pain relief on the improvement in daily functioning and quality of life (QOL) for depressed patients receiving a 6-week treatment of fluoxetine.",
"A total of 131 acutely ill inpatients with major depressive d... | yes |
10,334,896 | Is small bowel adaptation dependent on site of massive enterectomy? | {
"contexts": [
"Changes in amino acid transport after massive enterectomy occur in a nutrient-dependent fashion and may affect long-term outcome. Epidermal growth factor (EGF) can enhance nutrient transport and a defective epidermal growth factor receptor (EGF-R) has been noted to attenuate adaptation. Most anim... | yes |
23,271,076 | Does bicarbonate therapy in severely acidotic trauma patients increase mortality? | {
"contexts": [
"Normally, end-tidal CO(2) is within 2 mm Hg of arterial PO(2) (PaCO(2)). However, if dead space in the lungs increases owing to shock with poor lung perfusion, the arterial-end tidal PCO(2) difference [P(a-ET)CO(2)] increases. We have found that in severely injured patients, P(a-ET)CO(2) of less ... | yes |
23,189,850 | Is [ Genetic variation of IL-28B associated with treatment response of patients with chronic hepatitis C ]? | {
"contexts": [
"To explore the effect of IL-28B variation on the response of patients with chronic hepatitis C virus (HCV) infection to therapy.",
"A total of 220 patients with chronic hepatitis C (CHC) were prospectively treated with pegilated interferon (peg-IFN) in combination with ribavirin (RBV) for 48 ... | yes |
17,550,407 | Is distinct labelling of fusion events in rat lactotrophs by FM 1-43 and FM 4-64 associated with conformational differences? | {
"contexts": [
"Conformational analysis of fluorescent styryl dyes FM 1-43 and FM 4-64 was undertaken to clarify if distinct activity-dependent labelling of single lactotrophs vesicles and plasma membrane by two dyes is associated with their structural differences.",
"The activity-dependent labelling of sing... | yes |
25,433,270 | Is pKCε a negative regulator of PVAT-derived vessel formation? | {
"contexts": [
"Vessel formation is a crucial event in tissue repair after injury. Thus, one assumption of innovative therapeutic approaches is the understanding of its molecular mechanisms. Notwithstanding our knowledge of the role of Protein Kinase C epsilon (PKCε) in cardio-protection and vascular restenosis,... | yes |
19,212,267 | Do clonidine and dexmedetomidine produce antinociceptive synergy in mouse spinal cord? | {
"contexts": [
"Synergy between drugs manifests with increased potency and/or efficacy of the combination relative to either agonist given alone. Synergy is typically observed between drugs of different classes, as is the case with the alpha-adrenergic-opioid receptor synergy often observed in preclinical studie... | yes |
9,529,703 | Is support available . Assisting patients with severe sight loss? | {
"contexts": [
"There are a large number of free services for people who are blind or vision impaired.",
"As the population of Australia ages, it is becoming increasingly important that general practitioners have an understanding of the range of services available to people with disabilities."
],
"labels... | yes |
24,304,929 | Do leukemia cells induce changes in human bone marrow stromal cells? | {
"contexts": [
"Bone marrow stromal cells (BMSCs) are multipotent cells that support angiogenesis, wound healing, and immunomodulation. In the hematopoietic niche, they nurture hematopoietic cells, leukemia, tumors and metastasis. BMSCs secrete of a wide range of cytokines, growth factors and matrix proteins whi... | yes |
26,873,905 | Does empagliflozin reduce body weight and indices of adipose distribution in patients with type 2 diabetes mellitus? | {
"contexts": [
"To determine the effects of empagliflozin on adiposity indices among patients with type 2 diabetes mellitus.",
"Changes in weight, waist circumference, estimated total body fat, index of central obesity and visceral adiposity index were assessed using analysis of covariance and testing of tre... | yes |
1,597,038 | Does dimethylthiourea ameliorate acute lung injury induced by phorbol myristate acetate in dogs? | {
"contexts": [
"The protective effects of dimethylthiourea, a potent scavenger of hydroxy radical (.OH) and hydrogen peroxide, in experimental lung injury in large animals remain controversial. The present study was designed to determine whether dimethylthiourea can ameliorate the acute lung injury produced in d... | yes |
26,367,194 | Does electro-hyperthermia inhibit glioma tumorigenicity through the induction of E2F1-mediated apoptosis? | {
"contexts": [
"Modulated electro-hyperthermia (mEHT), also known as oncothermia, shows remarkable treatment efficacies for various types of tumours, including glioma. The aim of the present study was to investigate the molecular mechanism underlying phenotypic changes in oncothermic cancer cells.",
"U87-MG ... | yes |
20,834,104 | Is self-reported adherence more predictive of virological treatment response among patients with a lower tendency towards socially desirable responding? | {
"contexts": [
"Self-report is the most commonly used measure of adherence to highly active antiretroviral therapy, but typically shows weaker associations with virological treatment outcome than more objective adherence assessment methods. Socially desirable responding might hamper the validity of self-reported... | yes |
25,978,043 | Is cardiac development in zebrafish and human embryonic stem cells inhibited by exposure to tobacco cigarettes and e-cigarettes? | {
"contexts": [
"Maternal smoking is a risk factor for low birth weight and other adverse developmental outcomes.",
"We sought to determine the impact of standard tobacco cigarettes and e-cigarettes on heart development in vitro and in vivo.",
"Zebrafish (Danio rerio) were used to assess developmental eff... | yes |
18,060,493 | Is routine prophylactic granulocyte colony stimulating factor ( GCSF ) necessary with accelerated ( dose dense ) paclitaxel for early breast cancer? | {
"contexts": [
"Prophylactic granulocyte colony stimulating factor (GCSF) is recommended with accelerated adjuvant chemotherapy but is expensive and causes bone pain. We have reviewed a series of patients with early breast cancer treated with accelerated 2-weekly paclitaxel without routine GCSF to assess its nee... | no |
20,353,436 | Is epidermal growth factor 's activation of Ras inhibited by four cardiac hormones? | {
"contexts": [
"Four cardiac hormones synthesized by the same gene, i.e. atrial natriuretic peptide, vessel dilator, kaliuretic peptide and long-acting natriuretic peptide, have anticancer effects in vitro and in vivo. Epidermal growth factor's mechanism of cancer formation involves the activation of Ras.",
... | yes |
26,492,970 | Is the LRR receptor Islr2 required for retinal axon routing at the vertebrate optic chiasm? | {
"contexts": [
"In the visual system of most binocular vertebrates, the axons of retinal ganglion cells (RGCs) diverge at the diencephalic midline and extend to targets on both ipsi- and contralateral sides of the brain. While a molecular mechanism explaining ipsilateral guidance decisions has been characterized... | yes |
20,575,720 | Does telemedicine in urban and suburban childcare and elementary schools lighten family burdens? | {
"contexts": [
"Acute illness challenges all families with young children. The Health-e-Access Telemedicine Network in Rochester, NY, has enabled >7,000 telemedicine visits since 2001 among children in childcare or elementary schools, predominantly from Rochester's inner city. Large reductions in illness-related... | yes |
27,716,377 | Do urine biomarkers give early prediction of acute kidney injury and outcome after out-of-hospital cardiac arrest? | {
"contexts": [
"Post-resuscitation care after out-of-hospital cardiac arrest (OHCA) is challenging due to the threat of organ failure and difficult prognostication. Our aim was to examine whether urine biomarkers could give an early prediction of acute kidney injury (AKI) and outcome.",
"This was a prospecti... | yes |
27,122,766 | Does hydrogen Peroxide modulate Electrophysiological Characteristics of Left Atrial Myocytes? | {
"contexts": [
"Oxidative stress plays an important role in the pathophysiology of atrial fibrillation (AF). The hydrogen peroxide (H2O2) mainly underlies the cellular oxidative stress and free radicals. Left atrium (LA) is the most important AF substrate. However, the effects of H2O2 on the action potential (AP... | yes |
23,072,359 | Does marek 's disease virus infection induce widespread differential chromatin marks in inbred chicken lines? | {
"contexts": [
"Marek's disease (MD) is a neoplastic disease in chickens caused by the MD virus (MDV). Successful vaccine development against MD has resulted in increased virulence of MDV and the understanding of genetic resistance to the disease is, therefore, crucial to long-term control strategies. Also, epig... | yes |
23,434,945 | Does preoperative pulmonary embolism predict poor postoperative outcomes in patients with renal cell carcinoma and venous thrombus? | {
"contexts": [
"Patients with renal cell carcinoma who present with pulmonary embolism and venous thrombus may not be offered surgery because of presumed poor postoperative outcomes. In this multicenter study we evaluated perioperative mortality, recurrence and cancer specific survival in patients with renal cel... | no |
25,385,840 | Are otolaryngologic surgeries frequent in children with eosinophilic esophagitis? | {
"contexts": [
"The aim was to study the prevalence of otolaryngologic surgeries in pediatric patients with eosinophilic esophagitis (EoE).",
"Retrospective cohort study at a tertiary care center. The type of otolaryngologic surgeries performed in patients with diagnosis of EoE was recorded during a 5-year p... | yes |
19,806,414 | Do can a motivational intervention overcome an unsupportive environment for walking -- findings from the Step-by-Step Study? | {
"contexts": [
"Interventions to promote walking have rarely examined how their effects varied by the attributes of the physical environment.",
"The purpose of this study is to examine whether perceptions of environmental walkability predicted change in walking behavior following an individual-based interven... | yes |
26,331,770 | Is fetal human airway smooth muscle cell production of leukocyte chemoattractants differentially regulated by fluticasone? | {
"contexts": [
"Adult human airway smooth muscle (ASM) produce cytokines involved in recruitment and survival of leukocytes within airway walls. Cytokine generation by adult ASM is glucocorticoid-sensitive. Whether developing lung ASM produces cytokines in a glucocorticoid-sensitive fashion is unknown.",
"Cu... | yes |
23,635,343 | Does development and validation of a questionnaire for analyzing real-life fall in long-term care captured on video? | {
"contexts": [
"Falls are the number one cause of injuries in older adults, and are particularly common in long-term care (LTC). Lack of objective evidence on the mechanisms of falls in this setting is a major barrier to prevention. Video capture of real-life falls can help to address this barrier, if valid tool... | yes |
16,374,604 | Is nuchal cord associated with adverse perinatal outcome? | {
"contexts": [
"The present study was aimed at evaluating the outcome of pregnancies with nuchal cord.",
"A retrospective population-based study of all deliveries during the years 1988-2003 in a tertiary medical center was conducted. Immediate perinatal outcome of patients with and without nuchal cord was co... | no |
17,302,605 | Is phosphoinositide 3-kinase overexpressed in melanocytic lesions? | {
"contexts": [
"Although various studies have stressed the role of phosphatase and tensin homologue deleted on chromosome 10 (PTEN)-PI3K-AKT pathway in the progression of melanocytic lesions, little is known about the expression pattern of PI3K in these lesions.",
"To investigate the expression pattern of PI... | no |
23,702,039 | Does ginseng-Aconite Decoction elicit a positive inotropic effect via the reverse mode Na+/Ca2+ exchanger in beating rabbit atria? | {
"contexts": [
"Ginseng-Aconite Decoction (GAD), a traditional oriental medicine composed of Panax ginseng C.A. Mey. (Araliaceae) and Aconitum carmichaeli Debx. (Ranunculaceae) has been used as treatment for cardiovascular diseases from Song Dynasty of China. The purpose of the present study was to elucidate the... | yes |
9,562,546 | Does a single dipeptide sequence modulate the redox properties of a whole enzyme family? | {
"contexts": [
"Disulfide exchange reactions are catalyzed by thiol/disulfide oxidoreductases. These enzymes possess a thioredoxin fold and contain a catalytic disulfide with the sequence Cys-X-X-Cys at the N terminus of an alpha helix. Despite these similarities, the various members differ strongly in their red... | yes |
27,664,312 | Are cognitive function and health literacy independently associated with heart failure knowledge? | {
"contexts": [
"Determine the relationship between cognitive function and health literacy in heart failure (HF) knowledge in patients with HF.",
"HF requires extensive, complex treatment; thus, cognition and health literacy may contribute to understanding and self-management of HF.",
"Participants were 3... | yes |
12,928,771 | Is diabetic nephropathy associated with low-grade inflammation in Type 1 diabetic patients? | {
"contexts": [
"Increased concentrations of C-reactive protein and interleukin-6, a finding suggestive of the presence of inflammation, have been observed in Type 2 diabetes. In such patients, C-reactive protein was predictive of diabetic nephropathy. Studies on low-grade inflammatory markers and nephropathy in ... | yes |
18,248,108 | Does positive affect uniquely predict lower risk of mortality in people with diabetes? | {
"contexts": [
"To determine whether positive affect predicts mortality among people with diabetes and among a comparison group of people with no chronic health conditions.",
"Longitudinal cohort study.",
"Mortality.",
"Positive affect was significantly associated with lower risk of all-cause mortali... | yes |
20,384,595 | Does nitric oxide bioavailability modulate the dynamics of microvascular oxygen exchange during recovery from contractions? | {
"contexts": [
"lowered microvascular PO(2) (PO(2) mv) during the exercise off-transient likely impairs muscle metabolic recovery and limits the capacity to perform repetitive tasks. The current investigation explored the impact of altered nitric oxide (NO) bioavailability on PO(2) mv during recovery from contra... | yes |
11,292,010 | Are nicotine-induced enhancements in the five-choice serial reaction time task in rats strain-dependent? | {
"contexts": [
"Clinically, nicotine improves attention, but this has proven difficult to demonstrate preclinically. We tested nicotine in Sprague-Dawley (SD) and Lister hooded (LH) rats in the five-choice serial reaction time task. Since SD rats demonstrate lower asymptotic performance than LH rats, we surmised... | yes |
9,221,969 | Does apolipoprotein E epsilon4 allele decrease functional connectivity in Alzheimer 's disease as measured by EEG coherence? | {
"contexts": [
"The epsilon4 allele of apolipoprotein E (APOE) represents a major biological risk factor for late onset Alzheimer's disease. However, it is still not known whether the APOE genotype affects the progression of the disease, assessed by different functional methods.",
"The study sample included ... | yes |
16,303,707 | Does comparison between Japanese and Swedish schoolchildren in regard to physical symptoms and psychiatric complaints? | {
"contexts": [
"Physical symptoms are an increasing problem among Japanese children and adolescents, and the symptoms seem to be related to their school situation. These symptoms are prevalent in Sweden, and a comparison with Japan is of interest due to the differences in the educational system and school climat... | yes |
12,538,144 | Does vacuum-assisted venous drainage increase the neurological risk? | {
"contexts": [
"Vacuum-assisted venous drainage (VAVD) with negative pressure applied to integral sealed-hardshell venous reservoir facilitates valvular surgery through minimally invasive approaches. Despite concerns regarding air entrainment from the right atrium, cerebral microemboli of air and neurological co... | no |
27,400,477 | Does panax notoginseng saponins ameliorate experimental hepatic fibrosis and hepatic stellate cell proliferation by inhibiting the Jak2/ Stat3 pathways? | {
"contexts": [
"To investigate the inhibitory effect of Panax notoginseng saponins (PNS) on liver fibrosis and explore the underlying mechanisms.",
"Carbon tetrachloride (CCl4)-treated rats and hepatic stellate cells (HSCs) were used. The effect of PNS on CCl4-induced liver fibrosis was studied with histoche... | yes |
21,162,931 | Do [ Premedication with oral midazolam in children receive sevoflurane general anesthesia ]? | {
"contexts": [
"To investigate the effect of oral midazolam on sedation, on perioperative emotion and on behavior in children with sevoflurane general anesthesia.",
"48 children undergoing cataract surgeries were randomly divided into two groups and respectively received 0.5 mg/kg oral midazolam (Group I)and... | yes |
24,477,364 | Does narrow band imaging reliably predict residual intestinal metaplasia after radiofrequency ablation at the neo-squamo columnar junction? | {
"contexts": [
"After radiofrequency ablation (RFA) of Barrett's esophagus, it may be difficult to determine whether complete eradication of intestinal metaplasia at the neosquamocolumnar junction (neo-SCJ) in the cardia has been achieved. It is claimed that narrow band imaging (NBI) may predict the presence of ... | no |
23,168,376 | Is a skewed thiopurine metabolism a common clinical phenomenon that can be successfully managed with a combination of low-dose azathioprine and allopurinol? | {
"contexts": [
"A skewed thiopurine metabolism is a phenomenon associated with both poor treatment response and toxicity. Our aim was to evaluate the frequency of this phenomenon and the relationship to thiopurine methyltransferase (TPMT) function.",
"All thiopurine metabolite measurements in adult patients ... | yes |
21,649,463 | Do knockdown of β-Catenin through shRNA cause a reversal of EMT and metastatic phenotypes induced by HIF-1α? | {
"contexts": [
"Wnt/β-catenin signaling pathway regulates pattern formation during embryogenesis as well as tumor progression. Numbers of studies suggest that this signaling pathway may play an important role in Epithelial-Mesenchymal transition (EMT), however, there was no evidence that Wnt/β-catenin signaling ... | yes |
25,756,913 | Does obesity be Associated With More Complications and Longer Hospital Stays After Orthopaedic Trauma? | {
"contexts": [
"The objective of this study was to characterize relationships between obesity and initial hospital stay, including complications, in patients with multiple system trauma and surgically treated fractures.",
"Prospective, observational.",
"Level 1 trauma center.",
"Three hundred seventy... | yes |
26,950,259 | Are clinically significant anti-KEL RBC alloantibodies transferred by breast milk in a murine model? | {
"contexts": [
"Fetuses affected by maternal RBC alloantibodies may have prolonged anaemia after birth, leading one to question whether maternal alloantibody transfer may occur outside the placenta. In response to a recent publication describing breast milk transfer of clinically significant amounts of maternal ... | yes |
26,371,341 | Does pharmacological Elevation of Circulating Bioactive Phosphosphingolipids enhance Myocardial Recovery After Acute Infarction? | {
"contexts": [
"Acute myocardial infarction (AMI) triggers mobilization of bone marrow (BM)-derived stem/progenitor cells (BMSPCs) through poorly understood processes. Recently, we postulated a major role for bioactive lipids such as sphingosine-1 phosphate (S1P) in mobilization of BMSPCs into the peripheral blo... | yes |
23,932,619 | Does mathematical modelling of gubernaculum during inguino-scrotal migration show limb bud characteristics? | {
"contexts": [
"The gubernaculum is postulated to grow like an embryonic limb bud during inguinoscrotal descent in rodents. Recently, modelling of limb bud growth suggests the undifferentiated, distal \"progress zone\" provides molecular morphogenic signals, rather than cell division, as previously thought. We a... | no |
11,841,728 | Does intraventricular infusion of vascular endothelial growth factor promote cerebral angiogenesis with minimal brain edema? | {
"contexts": [
"Therapeutic cerebral angiogenesis, i.e., using angiogenic factors to enhance collateral vessel formation within the central nervous system, is a potential method for cerebral revascularization. Vascular endothelial growth factor (VEGF) is a potent endothelial cell mitogen that also increases capi... | yes |
18,973,145 | Are bladder sensations during filling cystometry different according to urodynamic diagnosis? | {
"contexts": [
"To determine the position and character of bladder filling sensations in women undergoing urodynamic investigations.",
"Women with lower urinary tract symptoms referred to urodynamic clinics of two tertiary referral teaching hospitals were prospectively studied. During filling cystometry the ... | yes |
8,874,620 | Do reduced CD4 cell counts in blood reflect CD4 cell depletion in tonsillar tissue in asymptomatic HIV-1 infection? | {
"contexts": [
"To investigate whether the loss of CD4 cells seen in peripheral circulation of HIV-1-positive individuals reflects a similar depletion of CD4 cells from lymphoid tissue.",
"CD4 and CD8 cells in tonsillar mononuclear cell suspensions were quantified relative to tonsillar B cells, as these were... | no |
20,423,520 | Does world Health Organization fracture risk assessment tool in the assessment of fractures after fall in hospital? | {
"contexts": [
"Falls are very common accidents in a hospital. Various risk factors and risk assessment tools are used to predict falls. However, outcomes of falls such as bone fractures have not been considered in these risk assessment tools, and the performance of risk assessment tools in a Japanese hospital s... | yes |
1,956,102 | Does rJR Nabisco 's cartoon camel promote camel cigarettes to children? | {
"contexts": [
"To determine if RJR Nabisco's cartoon-theme advertising is more effective in promoting Camel cigarettes to children or to adults. To determine if children see, remember, and are influenced by cigarette advertising.",
"Use of four standard marketing measures to compare the effects of Camel's O... | yes |
27,136,356 | Does papaverine prevent Vasospasm by Regulation of Myosin Light Chain Phosphorylation and Actin Polymerization in Human Saphenous Vein? | {
"contexts": [
"Papaverine is used to prevent vasospasm in human saphenous veins (HSV) during vein graft preparation prior to implantation as a bypass conduit. Papaverine is a nonspecific inhibitor of phosphodiesterases, leading to increases in both intracellular cGMP and cAMP. We hypothesized that papaverine re... | yes |
15,043,465 | Does cellular proliferative fraction measured with topoisomerase IIalpha predict malignancy in endocrine pancreatic tumors? | {
"contexts": [
"Endocrine pancreatic tumors (EPTs) are rare lesions with varying biological behavior. Establishing malignancy is a challenge for clinicians and pathologists.",
"To establish the role of proliferative, apoptotic, angiogenic, and hormonal markers as predictors of malignancy in EPTs.",
"Para... | yes |
20,440,566 | Does ferritin enhance SPIO tracking of C6 rat glioma cells by MRI? | {
"contexts": [
"To investigate the effect of ferritin protein overexpression on superparamagnetic iron oxide (SPIO) particle labeling of C6 rat glioma cells, and track the labeled cells in vivo using magnetic resonance imaging (MRI).",
"A plasmid of H-chain of murine ferritin gene was constructed and transfe... | yes |
18,854,398 | Is glucocorticoid receptor gene variant in the 3 ' untranslated region associated with multiple measures of blood pressure? | {
"contexts": [
"The glucocorticoid receptor (GR) is a key hormone in the hypothalamus-pituitary-adrenal axis that regulates many pathways including blood pressure homeostasis. Thus, GR gene variation may influence interindividual differences in blood pressure in human populations.",
"We resequenced individua... | yes |
22,904,162 | Are microRNAs related to angiogenesis dysregulated in endometrioid endometrial cancer? | {
"contexts": [
"Which is the role of microRNAs (miRNAs) related to several angiogenesis regulators such as VEGF-A (Vascular endothelial growth factor-A) and TSP-1 (Thrombospondin-1) in endometrial cancer?"
],
"labels": [
"OBJECTIVE"
],
"meshes": [
"Adult",
"Aged",
"Endometrial Neoplasms",... | yes |
20,668,304 | Does diindolylmethane ( DIM ) spontaneously form from indole-3-carbinol ( I3C ) during cell culture experiments? | {
"contexts": [
"Indole-3-carbinol (I3C) when given orally is converted to diindolylmethane (DIM) and other oligomers catalyzed by stomach acid. This suggests that DIM is the predominant active agent and that I3C is a precursor, 'pro-drug' in vivo. However, in cell culture studies carried out in neutral solutions... | yes |
16,428,356 | Does early postnatal allopurinol improve short term outcome after severe birth asphyxia? | {
"contexts": [
"To investigate whether postnatal allopurinol would reduce free radical induced reperfusion/reoxygenation injury of the brain in severely asphyxiated neonates.",
"In an interim analysis of a randomised, double blind, placebo controlled study, 32 severely asphyxiated infants were given allopuri... | no |
23,804,169 | Does poor compliance make treatment of latent tuberculosis infection unsatisfactory? | {
"contexts": [
"The recommended treatment for latent tuberculosis infection is isoniazid for 9 months, but this regimen has a low completion rate. The authors wanted to compare treatment with isoniazid and treatment with isoniazid and rifampin in the typical public health setting in a large diverse state and rec... | yes |
9,316,961 | Does a rapid increase in foot tissue temperature predict cardiovascular collapse during anaphylactic and anaphylactoid reactions? | {
"contexts": [
"Cardiovascular collapse during anaphylactic and anaphylactoid reactions results from release of histamine and other vasoactive substances. Intense arteriolar vasodilation associated with severe allergic reactions is likely to increase convective transfer of heat and peripheral tissue temperature,... | yes |
24,105,410 | Is general immune dampening associated with disturbed metabolism at diagnosis of type 1 diabetes? | {
"contexts": [
"Type 1 diabetes (T1D) is a serious diagnosis with the prospect of grave short- and long-term complications and even death if poorly managed. An attempt has been made to describe how clinical and immunological deviations might influence each other close to the diagnosis of T1D.",
"Sixty-nine n... | yes |
18,631,277 | Is pruritus a common and significant symptom of acne? | {
"contexts": [
"Acne is a common condition in both adolescents and adults. Characteristics of acne are well described, but itch is rarely mentioned as a clinical feature. Pruritus could be a significant contributory factor to the burden of disability in patients with acne.",
"We examine the prevalence of pru... | yes |
24,468,113 | Do reduced sphingosine kinase-1 and enhanced sphingosine 1-phosphate lyase expression demonstrate deregulated sphingosine 1-phosphate signaling in Alzheimer 's disease? | {
"contexts": [
"The accumulation of beta amyloid (Aβ) peptides, a hallmark of Alzheimer's disease (AD) is related to mechanisms leading to neurodegeneration. Among its pleiotropic cellular effects, Aβ accumulation has been associated with a deregulation of sphingolipid metabolism. Sphingosine 1-phosphate (S1P) d... | yes |
11,435,343 | Does downregulation of protein kinase C inhibit activation of mitochondrial K ( ATP ) channels by diazoxide? | {
"contexts": [
"The mitochondrial K(ATP) (mitoK(ATP)) channel has been shown to confer short- and long-term cardioprotection against prolonged ischemia via protein kinase C (PKC) signaling pathways. However, the exact association between PKC or its isoforms and mitoK(ATP) channels has not yet been clarified. The... | yes |
21,994,190 | Does genome-wide expression profiling implicate a MAST3-regulated gene set in colonic mucosal inflammation of ulcerative colitis patients? | {
"contexts": [
"Crohn's disease (CD) and ulcerative colitis (UC) are inflammatory bowel diseases (IBDs) presumably caused by dysregulated immune responses to the gut microbiota. Genetic association studies have implicated dozens of chromosomal regions or loci in IBD susceptibility. The next challenge is to expla... | yes |
16,334,438 | Does endogenous nitric oxide modulate small intestinal nutrient transit and activity in healthy adult humans? | {
"contexts": [
"Nitric oxide (NO) mechanisms have been shown to modulate fasting small intestinal motility in humans, but a role in the regulation of human postprandial small intestinal motility has not been assessed. The aim of this study was to evaluate the effect of the NO synthase inhibitor NG-monomethyl-L-a... | yes |
24,416,367 | Is first-episode medication-naive major depressive disorder associated with altered resting brain function in the affective network? | {
"contexts": [
"Major depressive disorder (MDD) has been associated with abnormal structure and function of the brain's affective network, including the amygdala and orbitofrontal cortex (OFC). However, it is unclear if alterations of resting-state function in this affective network are present at the initial on... | yes |
24,885,754 | Does a kinetic fluorescence assay reveal unusual features of Ca⁺⁺ uptake in Plasmodium falciparum-infected erythrocytes? | {
"contexts": [
"To facilitate development within erythrocytes, malaria parasites increase their host cell uptake of diverse solutes including Ca++. The mechanism and molecular basis of increased Ca++ permeability remains less well studied than that of other solutes.",
"Based on an appropriate Ca++ affinity a... | yes |
24,560,238 | Do why parents refuse newborn hearing screening and default on follow-up rescreening -- a South African perspective? | {
"contexts": [
"This study describes screen refusal and follow-up default characteristics together with caregiver reasons for screen refusal and follow-up default in two South African universal newborn hearing screening programs.",
"A retrospective record review of universal newborn hearing screening conduct... | yes |
27,426,968 | Do intra-articular basic calcium phosphate and monosodium urate crystals inhibit anti-osteoclastogenic cytokine signalling? | {
"contexts": [
"Basic calcium phosphate (BCP) and monosodium urate (MSU) crystals are particulates with potent pro-inflammatory effects, associated with osteoarthritis (OA) and gout, respectively. Bone erosion, due to increased osteoclastogenesis, is a hallmark of both arthropathies and results in severe joint d... | yes |
23,643,609 | Are interleukin-10 gene promoter polymorphisms associated with cyclosporin A-induced gingival overgrowth in renal transplant patients? | {
"contexts": [
"Interleukin-10 (IL-10) is an anti-inflammatory cytokine whose genetic polymorphisms are associated with the production of IL-10 and the susceptibility to periodontal diseases. The aim of this study was to investigate the possible association of IL-10 single nucleotide polymorphisms (SNPs) and cyc... | yes |
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