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His thoughts, sermons and discourses were published in his book Likutei Torah. | https://en.wikipedia.org/wiki/Mordechai%20Twersky | 8266373 | 5 | c9fff35c48dad47996e0fdc347855649f40683847fd7e65f7d904f18c2910105 | 78 | 16 |
References | https://en.wikipedia.org/wiki/Mordechai%20Twersky | 8266373 | 6 | c6d56004167af7bfa27e9ee51405fe7f422604692b41efeaef513f22b4c7413a | 10 | 1 |
People from Kiev Voivodeship | https://en.wikipedia.org/wiki/Mordechai%20Twersky | 8266373 | 7 | 2cae3c64642118835f710b1323f9f41725c56122a50a6d79105e552ce8e0902c | 28 | 7 |
Rebbes of Chernobyl | https://en.wikipedia.org/wiki/Mordechai%20Twersky | 8266373 | 8 | 80993db5ca5d8b6f4c72f9b5b7adab15a49aa9f1014f0bdec996e82f3c7430bc | 19 | 5 |
1770 births | https://en.wikipedia.org/wiki/Mordechai%20Twersky | 8266373 | 9 | 8c29fc58911a6e31ebc28db5db69e93ece6cb296cfcd0820139020f860c01513 | 11 | 5 |
1837 deaths | https://en.wikipedia.org/wiki/Mordechai%20Twersky | 8266373 | 10 | 5c96bcc642ccd094cc0887fb67c152a5afe3790fbd5c9dec43b30758ffbf0eae | 11 | 5 |
Chemokine (C-C motif) ligand 3 (CCL3) also known as macrophage inflammatory protein 1-alpha (MIP-1-alpha) is a protein that in humans is encoded by the CCL3 gene. | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 1 | b207fb58a84481fed2b596106ccb695c03fb90236451bbfc6194e97960cd5369 | 162 | 47 |
Function | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 2 | fc3b71fd69e4784fce80fcd63c5ce1b905db2f7410d8cf060d870a514fa8629a | 8 | 1 |
CCL3 is a cytokine belonging to the CC chemokine family that is involved in the acute inflammatory state in the recruitment and activation of polymorphonuclear leukocytes through binding to the receptors CCR1, CCR4 and CCR5. | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 3 | 0e9179660c231e675365c8e689552838cfdbcbb03adf2d04a900a9570487330d | 224 | 43 |
Sherry et al. (1988) demonstrated 2 protein components of MIP1, called by them alpha (CCL3, this protein) and beta (CCL4). | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 4 | d5df16ad7bb4bebaabc28aa3633451ba7f41e31b2902b208978b964b6203df17 | 122 | 37 |
CCL3 produces a monophasic fever of rapid onset whose magnitude is equal to or greater than that of fevers produced with either recombinant human tumor necrosis factor or recombinant human interleukin-1. However, in contrast to these two endogenous pyrogens, the fever induced by MIP-1 is not inhibited by the cyclooxyge... | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 5 | 9431a50657f616d086995f5082e7d6a0e8d81c0c7ed4e0c8399249681e66c9d8 | 498 | 92 |
Interactions | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 6 | 4f2230ef5ee6050218cba2a932d952fd0c330b54e83770ba026fa4bc107bc814 | 12 | 2 |
CCL3 has been shown to interact with CCL4. | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 7 | 09f92f8755139908eaacf21b7dbc3b97b1018dc44b681d8a3af1f0d79415dcdc | 42 | 11 |
Attracts macrophages, monocytes and neutrophils. | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 8 | 636981268d32aadfdeb2c4bb586def4bcbcc04fc238326400548b60857241d09 | 48 | 9 |
See also | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 9 | 411297a516b3a6a08c5af3f7945a813635d7a8a9a29f386d07d93f5a940154fd | 8 | 2 |
Macrophage inflammatory proteins | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 10 | d5a1af8e290ff1dbeb883d895c46d55618b76a332c8fd28d14a66f98538ee172 | 32 | 5 |
References | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 11 | 7ea95eb5c90a090b51748aab210870d5da3a117947996e4462968ac6df367b03 | 10 | 1 |
External links | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 12 | f7256a9c2f6d1618e27e98a9e5486c953815a095a74299d8cd514118a0244ac3 | 14 | 2 |
Further reading | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 13 | de41afe9b23bb2f759e348d65c9095ac30a25474a04f6d354c829212eeac5d40 | 15 | 2 |
Cytokines | https://en.wikipedia.org/wiki/CCL3 | 8266376 | 14 | d001aaa2d5e3516e56a8cc9fc025d850fa1dda51b1dd51eda3a3dd31a2b72299 | 9 | 2 |
Theodore Christian "Ted" Hines (September 9, 1926 - June 25, 1983) was a Washington, D.C.-born pioneer in the use of microcomputers and microcomputer programs in libraries. He attended undergraduate school at George Washington University and received his Masters of Library Science (MLS) in 1958 and a PhD in 1960 both ... | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 1 | 7f07d9a3e7e6bc3e00d98a0f2c80653ff499e62902db6727356c9aa393f83ed8 | 537 | 128 |
With his wife, Lois Winkel, he designed an indexing program called the Children’s Media Databank. The program was first constructed on a mainframe computer, and then transferred to a microcomputer for patron use. This program allowed a patron to search for children's books by subject and reading level. A sample search ... | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 2 | f0905b6e8d9818482066c47263fbe45a0b5847646ed1ef9d269d49f694e7d59e | 404 | 85 |
Hines convened the first meeting of the American Society of Indexers (ASI, now American Society for Indexing) in 1968. | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 3 | 0179ecb50b66993a88cf6dd9fe1c83ca6439395545e062f00455c83801d19e95 | 118 | 30 |
The ASI considers him its "founding father", and set up the Theodore C. Hines Award in his honor in 1993. | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 4 | 13fb118f32beb5a74160b8e8debbeb643272b6e97d4a3eaa1a49a49622650e08 | 105 | 29 |
Publications | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 5 | 4fad429aa7c384f053104fc687ad0bb5c865cd66f30c9fa58f659e637165674d | 12 | 1 |
"The Crisis in Children's Cataloging" Library Journal (September 15, 1966) | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 6 | 4b492227fdc163d96cbde43a6fc07c55129ee9c80968d5d13a5310451f8f7875 | 75 | 25 |
"Computer Filing of Index, Bibliographic, and Catalog Entries" (BroDart, 1966) written with Jessica Harris | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 7 | 58f73d8cf4c0aa45ef07e92756e7f7d8848bbdedb520249c75fc0ffe52e248f4 | 106 | 27 |
"Terminology of Library and Information Science: A Selective Glossary" (Columbia University School of Library Service, 1971). | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 8 | 3824d8edb077b196072e3f7fe0bf0d900f3894bbb38308e16c3358266c1aba16 | 125 | 26 |
Translation of Louise-Noelle Malcles' "La Bibliographic" (1961) | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 9 | e4d0634fa60af2b30e5db0498b1ad6854eac6bf9d7194dcc51a82da75970077c | 63 | 20 |
References | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 10 | cc92b8f0c8844e39e3b22ac3c5e2cbb6c27265839fed4e36843a5bdfb7288077 | 10 | 1 |
1926 births | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 11 | 81440a61e219dd1c453d6d384a6ae7eab7c50cf35b7bf58ddc01a006e7aa6318 | 11 | 5 |
1983 deaths | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 12 | 6be5a251dae3bd9e75a58bc0c46dc93ac72399263514056da65ad158eb03ab0e | 11 | 5 |
American librarians | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 13 | bd2e6a7f0c5c9a2aa685c5f886f1127f4d2ee7ed4f38b7a16dd9fb4d6ad05afd | 19 | 2 |
Columbia University faculty | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 14 | beba77cb585a756a030b55638602a0e3236dce9e7fe3a445ae1433bfb63aab04 | 27 | 3 |
George Washington University alumni | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 15 | a105e818677ac8038684e7db6748d05a7e46d173bd7fe261eacef19c54c35ac1 | 35 | 4 |
Founders of learned societies | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 16 | c1c7b0a319c020b625bcfdfce09dd9e9e290f484fc0d46f0f09f5c0e2f4cc71c | 29 | 5 |
People from Washington, D.C. | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 17 | 29e8a52b5483dfe341740043e4600e3f0c97c36853a5402eb4b25f9b66251024 | 28 | 8 |
Rutgers University alumni | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 18 | cc85e9441f46d95c09b9b8b63875fd7208892ed6a47ca6a7d47e565b8011959f | 25 | 4 |
Rutgers University faculty | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 19 | 596219c8c07d91aa8437d7ab3d83676ee21e70f84f000437e249ff70922e45f0 | 26 | 4 |
Place of death missing | https://en.wikipedia.org/wiki/Ted%20Hines | 8266390 | 20 | 774a016d104a1bddd1b402a7909bb9894d4d9ccb398d383951f2343dbc6efbe2 | 22 | 4 |
Sibylle of Cleves (17 January 1512 – 21 February 1554) was electress consort of Saxony. | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 1 | c9b5549f0a70dff9270a57c08757a18e6efd5b8831f319779bc30e9969d17b8d | 87 | 32 |
Born in Düsseldorf, she was the eldest daughter of John III of the House of La Marck, Duke of Jülich jure uxoris, Cleves, Berg jure uxoris, Count of Mark, also known as de la Marck and Ravensberg jure uxoris (often referred to as Duke of Cleves) who died in 1538, and his wife Maria, Duchess of Julich-Berg (1491–1543). ... | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 2 | 6dc0744a7dd59bfb923b34360a3693a1b0feb42e7c25870c468889fcd3f09a98 | 463 | 133 |
Life | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 3 | 0eca16fa568b25028d172eeb3342b635c936201782834e24a0e84c6ad6060985 | 4 | 1 |
In September 1526, Sibylle was betrothed to Electoral Prince John Frederick of Saxony in the Schloss Burg an der Wupper. After lengthy negotiations about the dowry, the lavish wedding ceremony, preceded by an elaborate procession, took place in Torgau on 9 February 1527. They had four sons. | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 4 | c73f11b5706fa7cd51694c3097c712daeda6b79f4bb8ad2f50b10a811529ebfa | 291 | 69 |
After the death of his father in 1532, Johann Friedrich became the elector of Saxony and Sibylle the electress. | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 5 | d6e72e3de7057954a1266138fcc096dfcf84d38af5e5c90825c5035b0ac45bb2 | 111 | 27 |
The correspondence between Sibylle and her husband during his captivity as a consequence of the Schmalkaldic War, showed a devoted and intimate couple. In the meanwhile, during the siege of Wittenberg, the electress protected the city in her husband's absence. To save his wife and sons, and to prevent Wittenberg from b... | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 6 | 3f1361fb33c211898e7f2dd52d8290a4c49948c40fb42b3a1db6438eaa6678d3 | 464 | 92 |
In 1552, after five years of captivity, the deposed elector was finally reunited with his family. However, the reunion was short-lived: in 1554 both Sibylle and Johan Frederick I died within a month of each other. They were buried in the City Church of Weimar. | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 7 | 8c4acd2696ee1e9c00975e0c9a337d8a76d20be0b8f26477acb151ce92236e57 | 260 | 63 |
Like her husband, Sibylle was a staunch supporter of the Reformation. The Thuringian reformer Justus Menius dedicated to her the mirrors for princes writing Oeconomia Christiana. | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 8 | d8686d8702705c57ba3b170a5896241e2ae4d4050a49dc112bb6c271663b43a5 | 178 | 35 |
Issue | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 9 | 58ff265a971db4e4139fdeb78803aee0c11a34d1aff31e82797507e52e4fb404 | 5 | 1 |
John Frederick II, Duke of Saxony (b. Torgau, 8 January 1529 – d. as imperial prisoner at Schloss Steyr, Upper Austria, 19 May 1595). | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 10 | 88b2958d8446012c3369617679ff3caa6ea99548814696f0139e2843396b66e5 | 133 | 46 |
John William, Duke of Saxe-Weimar (b. Torgau, 11 March 1530 – d. Weimar, 2 March 1573). | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 11 | 44912009d1aef84c3a95a9bc8f0a60387f3158740636d116559c3c9723134818 | 87 | 40 |
John Ernest (b. Weimar, 5 January 1535 – d. Weimar, 11 January 1535). | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 12 | 1ba27abddedc560f4c3a5df87e6d886a9e0c13ba9b64a9a166e5dde5bcdeab55 | 69 | 30 |
John Frederick III, Duke of Saxony, called the Younger (b. Torgau, 16 January 1538 – d. Jena, 31 October 1565). | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 13 | 31d4322689d1116dd8350ac8906ed79ee63c4c564a7bb1bbe00269a4631f7d8e | 111 | 42 |
Notes | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 14 | 34d7f4e6006d20ca5f5c9c3cf7684983775039051dbbb911011df11d86069b9a | 5 | 1 |
References | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 15 | 8f1fe9636eb741513f430ec744d9f5bf07b9468ca540892923dee82e499c63d0 | 10 | 1 |
Faith and Power: Saxony in Europe during the Reformation period, Dresden 2004, p. 149. | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 16 | 702212da69daaec09d8100eabec9ea7504d3be2bdab7512d013676beb509be73 | 86 | 27 |
Joachim Bauer/Dagmar Blaha: The deaths of John Frederick and his wife Sibylle, in: Sächsische Heimatblätter 50 (2004), vol. I, pp. 78–84. | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 17 | fd75a2acad45bd071132664bf3ce232f6b6a203ff35708bcb93000b701d9a7d3 | 137 | 50 |
Carl August Hugo Burkhardt: Letters of Sybille of Jülich-Cleves-Berg to her husband John Frederick the Magnanimous, Elector of Saxony, in: Journal of the Berg Historical Society, vol. V, 1868, pp. 1–184. | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 18 | 03a222b6bab5d8f9873019f5d9b6ea3ebf4af0a36bfda6132f5a6b3a0671b295 | 203 | 64 |
Sylvia Weigelt: "The men pleasure and joy to be": women to Luther. Wartburg 2011. | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 19 | 908bbb8d001e228a563c5cc8d6f4530693aaaca1e126588dc8fec01e3b722fac | 81 | 27 |
Heinrich Theodor Flathe: Electress of Saxony, in: Allgemeine Deutsche Biographie (ADB). vol. 34, Duncker & Humblot, Leipzig 1892, p. 141. | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 20 | d458b84f3d99ced23a9d1ec28e9fc37dd8db9d4b199705afb222ea37593ee3e5 | 137 | 46 |
External links | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 21 | 967a777083baeab5ad2fa521b320c2ba86bbc2bda30b6c9f710aa6f5f797f9eb | 14 | 2 |
People from the Duchy of Cleves | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 22 | 3e8b95547e06d0369de7e5d62eb0f48b9f14a49b63db0b256c31e9eca4fc0445 | 31 | 8 |
House of La Marck | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 23 | d5b7b848478ee052b297e32e7fa8709c4a871df5d3e1c2e73845c02b439258ed | 17 | 5 |
House of Wettin | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 24 | de03c237887c5f43093d85d79359be9d98ed24b80d65b74c673623302e0589a0 | 15 | 4 |
Nobility from Düsseldorf | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 25 | 45533a3cda654c26c42e6554c65d9368de28749624f0a7f42467e9edc4529359 | 24 | 4 |
1512 births | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 26 | a971b836da639fcd2e762d3b500ce630b063578ced36247c32fc303af4cb37e2 | 11 | 5 |
1554 deaths | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 27 | dd62b09cbc97fb33bb61682beaa6e5f3816fbd814e732634ee420b8bbb6e3cb9 | 11 | 5 |
Duchesses of Saxony | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 28 | b9f79eff8b1ff7062b6373bec7bac50366f048be6c97b8986a2f11c7a215583b | 19 | 5 |
Electresses of Saxony | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 29 | 2965a93129c710b4b225d6f3edfdfa8a7665fdf0326557a6122ea2143ab1094f | 21 | 4 |
Women in 16th-century warfare | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 30 | 3e829882b79c990453cca976a39d85eded692937c7f9df27caadf1fd8b861033 | 29 | 9 |
Women in European warfare | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 31 | c2f94f20f4551068bf33847ed64e2f2a4adb2634a300167f42c7b8e78aca6b2e | 25 | 4 |
16th-century letter writers | https://en.wikipedia.org/wiki/Sibylle%20of%20Cleves | 8266394 | 32 | f08056492a90fa44eeb7d7d06f679e65d4f0a655168115788c5a7fae8b0650a7 | 27 | 7 |
Chemokine (C-C motif) ligands 4 (also CCL4) previously known as macrophage inflammatory protein (MIP-1β), is a protein which in humans is encoded by the CCL4 gene. CCL4 belongs to a cluster of genes located on 17q11-q21 of the chromosomal region. Identification and localization of the gene on the chromosome 17 was in ... | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 1 | 795223370a850ebbe5f43cc5359cff26313f459e7f9b54e412edb7c320c1060c | 637 | 155 |
CCL4 is a small cytokine that belongs to the CC chemokine subfamily. CCL4 is being secreted under mitogenic signals and antigens and hereby acts as a chemoattractant for natural killer cells, monocytes and various other immune cells in the site of inflamed or damaged tissue. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 2 | 593c1ef4e9fbcf102f8ea866f81041870c41bf469cdf543ed55e347a4d874536 | 275 | 54 |
Genomics | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 3 | a0d88769df26c4c27f4740355e6389d26cd10aa2dc3bedf5310da4000cf85d91 | 8 | 2 |
In the human genome, CCL4 and many other CC chemokines is encoded by a single gene on chromosome 17 (17q11-q21). The CCL4 gene consists of three exons and two introns which are separated by 14 kb and are organized in a head to head fashion. MIP-1 genes have 3 untranslated gene regions containing a polyadenylation site ... | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 4 | fed4a51132c7b02b4307fa49473a4c8cd62bad73c56c4e0f1f40a8358d5e27a8 | 592 | 157 |
Molecular structure | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 5 | e6adb4ce8d46d73f97aebcc9c84b93f5e624472e0d940f71caedbd96a79c643e | 19 | 2 |
CCL4 is a polypeptide chain with a molecular weight of approximately 8-10 kDa arranged in a three-dimensional structure in the form of as symmetrical homodimer. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 6 | 8fbb20e084dfedfb1b4841983f1c81e79ff458077d30b5dd8b100292cdfefd39 | 160 | 35 |
Monomeric subunits in their secondary structure composed by a triple-stranded antiparallel sheet form in a Greek key structure on top of which lies an α-helix. NH2-terminus is arranged as a long loop followed by a four-residue helical turn. The overall form of homodimer is globular elongated and cylindrical with sizes:... | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 7 | e5efe29f7ff73e4c33694703f8f01356a9e3f91148c754948f29f1531bbbccd2 | 398 | 98 |
CCL4 as well as other MIP-1s whether human or mouse have a high tendency to self-aggregation. Aggregation as a reversible and dynamic process depends largely on the concentration of chemokine. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 8 | 793c48b73b6bd2fa2d5a0bfb54ccc7155679c553e41c217cc797ff1183251c01 | 192 | 39 |
The distinction between the CC chemokine families, MIP-1α and MIP-1β, was initially based on whether the first two cysteine residues are separated by one residue (α) or are adjacent (β). Final form of tertiary structure structure of MIP-1 has been defined by heteronuclear magnetic resonance (NMR) analysis. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 9 | b357c97013cb0fd9a663a7f1f27f892a73b31c911af7a70ac4d58a6d6bbba741 | 307 | 65 |
Concentration of this chemokine has been shown to be inversely related with MicroRNA-125b. Concentration of CCL4 within the body increases with age, which may cause chronic inflammation and liver damage. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 10 | 7dd9d02d3be1734a85b5fca952a8758dca175492b41fc8fda4eda703c3bd1bda | 203 | 41 |
Function | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 11 | 796314be7395545790bd3e1ebdba6aa72392e9a429d6c0422ce1193cdecf21f8 | 8 | 1 |
CCL4 as a chemokine which is produced during inflammation, damage or other important dynamic processes as an angiogenesis to attract immune cells as leukocytes transgress the vascular endothelium and migrate into peripheral tissues. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 12 | e88bbbb579365e41efa8b88740e17218ddce66d4b0d4a5c9931240bb6d45a9a3 | 232 | 36 |
Production of CCL4 | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 13 | 37e6f3536c3f2b76bcf2edfff04177e2dbc7278cdf6250d7f30c46d8ec1c52d8 | 18 | 4 |
CCL4 is produced by: monocytes, B cells, T cells, NK cells, dendritic cells, neutrophils, fibroblasts, endothelial cells such as vascular smooth muscle cells, brain microvessel endothelial cells, fetal microglia and epithelial cells. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 14 | 5d303f28e66b86cc4330d8050ed9ad03445782921b7af613e04716a501491b88 | 233 | 46 |
Monocytes produce high amounts of CCL4 when they are stimulated with LPS or IL-7 and production is suppressed by IL-4. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 15 | 86af9516838b3fe1bf5f5a5815685a3b54906c9837b92b49c27b47d6b62f62ec | 118 | 27 |
T cells and B cells secrete CCL4 response to Ag receptor (BCR) triggering. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 16 | c95fb1e44b1f9faac1c91210ffe92218cadfed0c67042d5ee7922a7f867344bd | 74 | 18 |
NK cells produce CCL4 in response to stimulation with IL-2, physiological activation signals such as lysis. NK cells can be important source of CC chemokines and may suppress HIV infection by inhibition replication of HIV-1 virus by interfering with the ability to utilize CCR5 as a coreceptor for entry in CD4(+) cells. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 17 | 43bd0ed401bacb81a9c93f6165dbe2dd34329feeddd1c4af28a4f52043ec16ee | 320 | 65 |
Dendritic cells secrete and respond to chemokines after stimulation to LPS, TNFα, or CD40 ligand. In maturing of DC production of chemokines have different impact on chemokine receptor function: CCR1 and CCR5 were down-regulated whereas CCR7 were stimulated increased in maturing DC. Production of chemokines provides DC... | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 18 | f2315e4367a50be4de543d0de7af16b2e3c7c211945311810039c04b80baf0d3 | 415 | 83 |
Neutrophils produce CCL4 in the presence of IFN-gamma and its inhibition by IL-10. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 19 | 0d502920e452751589c5e8eb24f523ba319c13b8e7815c2bae5290ce8b0da470 | 82 | 22 |
Endothelial cells release CCL4 following stimulation with LPS, TNFα, IFN-, or IL-1. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 20 | a3d43a88a48cb0433e4bbb7fe84b09741f5fd540fed887df54f4a6b27abb91d1 | 83 | 21 |
CCL4 is a major HIV-suppressive factor produced by CD8+ T cells. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 21 | 19ea9d4035df5cda6bcd65fb2d2a50bb0ec4e7312960539aced8724de924d685 | 64 | 18 |
Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 22 | 318271ccea19ea927e1067db8005b8c082bc6f08741ad943b0f0fde643e5c156 | 69 | 20 |
CCL4 is produced by: neutrophils, monocytes, B cells, T cells, fibroblasts, endothelial cells, and epithelial cells. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 23 | 9119a123197638209db87c143b7a02f3540a2d04aa5db1389c484f6df8fb9098 | 116 | 25 |
Interactions | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 24 | b0b00e93493f172ec8c39c29372de8f40665f97e7e48fca1a6e79ced0c9485eb | 12 | 2 |
CCL4 has been shown to interact with CCL3. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 25 | fd47d5c380c8be98819c1dd521d95e75c8853197e3433484e155a092f68de47e | 42 | 11 |
CCL4 binds to G protein-Coupled Receptors CCR5 and CCR8. | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 26 | def98c0ca6ca7e5c77a935f588e8a694e2afd5dbde3b1b3537bd68966996e39b | 56 | 17 |
See also | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 27 | cd2b442d1c9ef84fc9372ce65e9ed528683f6e8cd475d4a59d48fab171032adb | 8 | 2 |
Macrophage inflammatory protein | https://en.wikipedia.org/wiki/CCL4 | 8266398 | 28 | 1972275512851ff7e6b1f67b4bc7f401327ed8cb974c86d23f5e4ce5960793e8 | 31 | 5 |
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