id stringlengths 24 24 | title stringclasses 442 values | context stringlengths 151 3.71k | question stringlengths 12 270 | answers dict |
|---|---|---|---|---|
5706c3fa2eaba6190074acf9 | Atlantic_City,_New_Jersey | On April 29, 2011, the boundaries for the state-run tourism district were set. The district would include heavier police presence, as well as beautification and infrastructure improvements. The CRDA would oversee all functions of the district and will make changes to attract new businesses and attractions. New construction would be ambitious and may resort to eminent domain. | What were the three major things that the district would include? | {
"answer_start": [
79
],
"text": [
"The district would include heavier police presence, as well as beautification and infrastructure improvements"
]
} |
5706c3fa2eaba6190074acfa | Atlantic_City,_New_Jersey | On April 29, 2011, the boundaries for the state-run tourism district were set. The district would include heavier police presence, as well as beautification and infrastructure improvements. The CRDA would oversee all functions of the district and will make changes to attract new businesses and attractions. New construction would be ambitious and may resort to eminent domain. | Who would oversee all functions of the new district? | {
"answer_start": [
190
],
"text": [
"The CRDA"
]
} |
5706c3fa2eaba6190074acfb | Atlantic_City,_New_Jersey | On April 29, 2011, the boundaries for the state-run tourism district were set. The district would include heavier police presence, as well as beautification and infrastructure improvements. The CRDA would oversee all functions of the district and will make changes to attract new businesses and attractions. New construction would be ambitious and may resort to eminent domain. | Who would make the changes within the district to attract new businesses and attractions? | {
"answer_start": [
190
],
"text": [
"The CRDA"
]
} |
5706c3fa2eaba6190074acfc | Atlantic_City,_New_Jersey | On April 29, 2011, the boundaries for the state-run tourism district were set. The district would include heavier police presence, as well as beautification and infrastructure improvements. The CRDA would oversee all functions of the district and will make changes to attract new businesses and attractions. New construction would be ambitious and may resort to eminent domain. | What two qualities were mentioned in regards to new construction? | {
"answer_start": [
325
],
"text": [
"would be ambitious and may resort to eminent domain"
]
} |
5706d3592eaba6190074ad1c | Atlantic_City,_New_Jersey | The tourism district would comprise several key areas in the city; the Marina District, Ducktown, Chelsea, South Inlet, Bader Field, and Gardner's Basin. Also included are 10 roadways that lead into the district, including several in the city's northern end, or North Beach. Gardner's Basin, which is home to the Atlantic City Aquarium, was initially left out of the tourism district, while a residential neighborhood in the Chelsea section was removed from the final boundaries, owing to complaints from the city. Also, the inclusion of Bader Field in the district was controversial and received much scrutiny from mayor Lorenzo Langford, who cast the lone "no" vote on the creation of the district citing its inclusion. | How many roadways will be included in the district? | {
"answer_start": [
172
],
"text": [
"10"
]
} |
5706d3592eaba6190074ad1d | Atlantic_City,_New_Jersey | The tourism district would comprise several key areas in the city; the Marina District, Ducktown, Chelsea, South Inlet, Bader Field, and Gardner's Basin. Also included are 10 roadways that lead into the district, including several in the city's northern end, or North Beach. Gardner's Basin, which is home to the Atlantic City Aquarium, was initially left out of the tourism district, while a residential neighborhood in the Chelsea section was removed from the final boundaries, owing to complaints from the city. Also, the inclusion of Bader Field in the district was controversial and received much scrutiny from mayor Lorenzo Langford, who cast the lone "no" vote on the creation of the district citing its inclusion. | What place is home to the Atlantic City Aquarium? | {
"answer_start": [
275
],
"text": [
"Gardner's Basin"
]
} |
5706d3592eaba6190074ad1e | Atlantic_City,_New_Jersey | The tourism district would comprise several key areas in the city; the Marina District, Ducktown, Chelsea, South Inlet, Bader Field, and Gardner's Basin. Also included are 10 roadways that lead into the district, including several in the city's northern end, or North Beach. Gardner's Basin, which is home to the Atlantic City Aquarium, was initially left out of the tourism district, while a residential neighborhood in the Chelsea section was removed from the final boundaries, owing to complaints from the city. Also, the inclusion of Bader Field in the district was controversial and received much scrutiny from mayor Lorenzo Langford, who cast the lone "no" vote on the creation of the district citing its inclusion. | What place was originally left off of the tourism district? | {
"answer_start": [
275
],
"text": [
"Gardner's Basin"
]
} |
5706d3592eaba6190074ad1f | Atlantic_City,_New_Jersey | The tourism district would comprise several key areas in the city; the Marina District, Ducktown, Chelsea, South Inlet, Bader Field, and Gardner's Basin. Also included are 10 roadways that lead into the district, including several in the city's northern end, or North Beach. Gardner's Basin, which is home to the Atlantic City Aquarium, was initially left out of the tourism district, while a residential neighborhood in the Chelsea section was removed from the final boundaries, owing to complaints from the city. Also, the inclusion of Bader Field in the district was controversial and received much scrutiny from mayor Lorenzo Langford, who cast the lone "no" vote on the creation of the district citing its inclusion. | Where was the residential neighborhood that was removed from the final boundaries of the district? | {
"answer_start": [
425
],
"text": [
"Chelsea"
]
} |
5706d3592eaba6190074ad20 | Atlantic_City,_New_Jersey | The tourism district would comprise several key areas in the city; the Marina District, Ducktown, Chelsea, South Inlet, Bader Field, and Gardner's Basin. Also included are 10 roadways that lead into the district, including several in the city's northern end, or North Beach. Gardner's Basin, which is home to the Atlantic City Aquarium, was initially left out of the tourism district, while a residential neighborhood in the Chelsea section was removed from the final boundaries, owing to complaints from the city. Also, the inclusion of Bader Field in the district was controversial and received much scrutiny from mayor Lorenzo Langford, who cast the lone "no" vote on the creation of the district citing its inclusion. | Who cast the lone "no" vote on the creation of the district citing Bader Field's inclusion? | {
"answer_start": [
616
],
"text": [
"mayor Lorenzo Langford"
]
} |
5706d4f80eeca41400aa0e5f | Atlantic_City,_New_Jersey | Atlantic City is considered as the "Gambling Capital of the East Coast," and currently has eight large casinos and several smaller ones. In 2011, New Jersey's casinos employed approximately 33,000 employees, had 28.5 million visitors, made $3.3 billion in gaming revenue, and paid $278 million in taxes. They are regulated by the New Jersey Casino Control Commission and the New Jersey Division of Gaming Enforcement. | What is Atlantic City known for? | {
"answer_start": [
36
],
"text": [
"Gambling Capital of the East Coast"
]
} |
5706d4f80eeca41400aa0e60 | Atlantic_City,_New_Jersey | Atlantic City is considered as the "Gambling Capital of the East Coast," and currently has eight large casinos and several smaller ones. In 2011, New Jersey's casinos employed approximately 33,000 employees, had 28.5 million visitors, made $3.3 billion in gaming revenue, and paid $278 million in taxes. They are regulated by the New Jersey Casino Control Commission and the New Jersey Division of Gaming Enforcement. | How many large casinos are located in Atlantic City? | {
"answer_start": [
91
],
"text": [
"eight"
]
} |
5706d4f80eeca41400aa0e61 | Atlantic_City,_New_Jersey | Atlantic City is considered as the "Gambling Capital of the East Coast," and currently has eight large casinos and several smaller ones. In 2011, New Jersey's casinos employed approximately 33,000 employees, had 28.5 million visitors, made $3.3 billion in gaming revenue, and paid $278 million in taxes. They are regulated by the New Jersey Casino Control Commission and the New Jersey Division of Gaming Enforcement. | Approximately how many people did New Jersey casinos employ in 2011? | {
"answer_start": [
190
],
"text": [
"33,000"
]
} |
5706d4f80eeca41400aa0e62 | Atlantic_City,_New_Jersey | Atlantic City is considered as the "Gambling Capital of the East Coast," and currently has eight large casinos and several smaller ones. In 2011, New Jersey's casinos employed approximately 33,000 employees, had 28.5 million visitors, made $3.3 billion in gaming revenue, and paid $278 million in taxes. They are regulated by the New Jersey Casino Control Commission and the New Jersey Division of Gaming Enforcement. | Approximately how many people visited New Jersey's casinos in 2011? | {
"answer_start": [
212
],
"text": [
"28.5 million"
]
} |
5706d4f80eeca41400aa0e63 | Atlantic_City,_New_Jersey | Atlantic City is considered as the "Gambling Capital of the East Coast," and currently has eight large casinos and several smaller ones. In 2011, New Jersey's casinos employed approximately 33,000 employees, had 28.5 million visitors, made $3.3 billion in gaming revenue, and paid $278 million in taxes. They are regulated by the New Jersey Casino Control Commission and the New Jersey Division of Gaming Enforcement. | What two entities regulate New Jersey's casino? | {
"answer_start": [
330
],
"text": [
"New Jersey Casino Control Commission and the New Jersey Division of Gaming Enforcement"
]
} |
5706d70e2eaba6190074ad26 | Atlantic_City,_New_Jersey | In the wake of the United States' economic downturn and the legalization of gambling in adjacent and nearby states (including Delaware, Maryland, New York, and Pennsylvania), four casino closures took place in 2014: the Atlantic Club on January 13; the Showboat on August 31; the Revel, which was Atlantic City's second-newest casino, on September 2; and Trump Plaza, which originally opened in 1984, and was the poorest performing casino in the city, on September 16. | How many casino closures took place in Atlantic City in 2014? | {
"answer_start": [
175
],
"text": [
"four"
]
} |
5706d70e2eaba6190074ad27 | Atlantic_City,_New_Jersey | In the wake of the United States' economic downturn and the legalization of gambling in adjacent and nearby states (including Delaware, Maryland, New York, and Pennsylvania), four casino closures took place in 2014: the Atlantic Club on January 13; the Showboat on August 31; the Revel, which was Atlantic City's second-newest casino, on September 2; and Trump Plaza, which originally opened in 1984, and was the poorest performing casino in the city, on September 16. | What was the name of the poorest performing casino in the city that ultimately closed in 2014? | {
"answer_start": [
355
],
"text": [
"Trump Plaza"
]
} |
5706d70e2eaba6190074ad28 | Atlantic_City,_New_Jersey | In the wake of the United States' economic downturn and the legalization of gambling in adjacent and nearby states (including Delaware, Maryland, New York, and Pennsylvania), four casino closures took place in 2014: the Atlantic Club on January 13; the Showboat on August 31; the Revel, which was Atlantic City's second-newest casino, on September 2; and Trump Plaza, which originally opened in 1984, and was the poorest performing casino in the city, on September 16. | What year did Trump Plaza originally open? | {
"answer_start": [
395
],
"text": [
"1984"
]
} |
5706d70e2eaba6190074ad29 | Atlantic_City,_New_Jersey | In the wake of the United States' economic downturn and the legalization of gambling in adjacent and nearby states (including Delaware, Maryland, New York, and Pennsylvania), four casino closures took place in 2014: the Atlantic Club on January 13; the Showboat on August 31; the Revel, which was Atlantic City's second-newest casino, on September 2; and Trump Plaza, which originally opened in 1984, and was the poorest performing casino in the city, on September 16. | What was the name of Atlantic City's second-newest casino that ultimately closed in 2014? | {
"answer_start": [
280
],
"text": [
"Revel"
]
} |
5706d70e2eaba6190074ad2a | Atlantic_City,_New_Jersey | In the wake of the United States' economic downturn and the legalization of gambling in adjacent and nearby states (including Delaware, Maryland, New York, and Pennsylvania), four casino closures took place in 2014: the Atlantic Club on January 13; the Showboat on August 31; the Revel, which was Atlantic City's second-newest casino, on September 2; and Trump Plaza, which originally opened in 1984, and was the poorest performing casino in the city, on September 16. | What was the name of the first casino to close in 2014? | {
"answer_start": [
220
],
"text": [
"Atlantic Club"
]
} |
5706d85a2eaba6190074ad36 | Atlantic_City,_New_Jersey | Executives at Trump Entertainment Resorts, whose sole remaining property will be the Trump Taj Mahal, said in 2013 that they were considering the option of selling the Taj and winding down and exiting the gaming and hotel business. | What is the sole remaining property owned by Trump Entertainment Group? | {
"answer_start": [
85
],
"text": [
"Trump Taj Mahal"
]
} |
5706d85a2eaba6190074ad37 | Atlantic_City,_New_Jersey | Executives at Trump Entertainment Resorts, whose sole remaining property will be the Trump Taj Mahal, said in 2013 that they were considering the option of selling the Taj and winding down and exiting the gaming and hotel business. | What did Trump Entertainment Group say they were considering doing with the Trump Taj Mahal? | {
"answer_start": [
156
],
"text": [
"selling"
]
} |
5706d85a2eaba6190074ad38 | Atlantic_City,_New_Jersey | Executives at Trump Entertainment Resorts, whose sole remaining property will be the Trump Taj Mahal, said in 2013 that they were considering the option of selling the Taj and winding down and exiting the gaming and hotel business. | In what year did executives at Trump Entertainment Group say they were considering selling the Taj? | {
"answer_start": [
110
],
"text": [
"2013"
]
} |
5706d85a2eaba6190074ad39 | Atlantic_City,_New_Jersey | Executives at Trump Entertainment Resorts, whose sole remaining property will be the Trump Taj Mahal, said in 2013 that they were considering the option of selling the Taj and winding down and exiting the gaming and hotel business. | Why did executives say they were considering selling the Taj? | {
"answer_start": [
176
],
"text": [
"winding down and exiting the gaming and hotel business"
]
} |
5706d85a2eaba6190074ad3a | Atlantic_City,_New_Jersey | Executives at Trump Entertainment Resorts, whose sole remaining property will be the Trump Taj Mahal, said in 2013 that they were considering the option of selling the Taj and winding down and exiting the gaming and hotel business. | Who spoke for the Trump Entertainment Group in regards to the Taj and what might be done in the future? | {
"answer_start": [
0
],
"text": [
"Executives"
]
} |
5706d97a2eaba6190074ad40 | Atlantic_City,_New_Jersey | Caesars Entertainment executives have been reconsidering the future of their three remaining Atlantic City properties (Bally's, Caesars and Harrah's), in the wake of a Chapter 11 bankruptcy filing by the company's casino operating unit in January 2015. | How many remaining properties belong to Caesars Entertainment? | {
"answer_start": [
77
],
"text": [
"three"
]
} |
5706d97a2eaba6190074ad41 | Atlantic_City,_New_Jersey | Caesars Entertainment executives have been reconsidering the future of their three remaining Atlantic City properties (Bally's, Caesars and Harrah's), in the wake of a Chapter 11 bankruptcy filing by the company's casino operating unit in January 2015. | What are the names of the three remaining Caesars Entertainment properties? | {
"answer_start": [
119
],
"text": [
"Bally's, Caesars and Harrah's"
]
} |
5706d97a2eaba6190074ad42 | Atlantic_City,_New_Jersey | Caesars Entertainment executives have been reconsidering the future of their three remaining Atlantic City properties (Bally's, Caesars and Harrah's), in the wake of a Chapter 11 bankruptcy filing by the company's casino operating unit in January 2015. | What type of bankruptcy did Caesars Entertainment file for? | {
"answer_start": [
168
],
"text": [
"Chapter 11"
]
} |
5706d97a2eaba6190074ad43 | Atlantic_City,_New_Jersey | Caesars Entertainment executives have been reconsidering the future of their three remaining Atlantic City properties (Bally's, Caesars and Harrah's), in the wake of a Chapter 11 bankruptcy filing by the company's casino operating unit in January 2015. | What year did Caesars Entertainment file for bankruptcy? | {
"answer_start": [
247
],
"text": [
"2015"
]
} |
5706d97a2eaba6190074ad44 | Atlantic_City,_New_Jersey | Caesars Entertainment executives have been reconsidering the future of their three remaining Atlantic City properties (Bally's, Caesars and Harrah's), in the wake of a Chapter 11 bankruptcy filing by the company's casino operating unit in January 2015. | Which unit of Caesars Entertainment filed for bankruptcy in 2015? | {
"answer_start": [
214
],
"text": [
"casino operating unit"
]
} |
5706de729e06ca38007e91cd | Atlantic_City,_New_Jersey | Boardwalk Hall, formally known as the "Historic Atlantic City Convention Hall", is an arena in Atlantic City along the boardwalk. Boardwalk Hall was Atlantic City's primary convention center until the opening of the Atlantic City Convention Center in 1997. The Atlantic City Convention Center includes 500,000 sq ft (46,000 m2) of showroom space, 5 exhibit halls, 45 meeting rooms with 109,000 sq ft (10,100 m2) of space, a garage with 1,400 parking spaces, and an adjacent Sheraton hotel. Both the Boardwalk Hall and Convention Center are operated by the Atlantic City Convention & Visitors Authority. | What was Boardwalk Hall formerly known as? | {
"answer_start": [
39
],
"text": [
"Historic Atlantic City Convention Hall"
]
} |
5706de729e06ca38007e91ce | Atlantic_City,_New_Jersey | Boardwalk Hall, formally known as the "Historic Atlantic City Convention Hall", is an arena in Atlantic City along the boardwalk. Boardwalk Hall was Atlantic City's primary convention center until the opening of the Atlantic City Convention Center in 1997. The Atlantic City Convention Center includes 500,000 sq ft (46,000 m2) of showroom space, 5 exhibit halls, 45 meeting rooms with 109,000 sq ft (10,100 m2) of space, a garage with 1,400 parking spaces, and an adjacent Sheraton hotel. Both the Boardwalk Hall and Convention Center are operated by the Atlantic City Convention & Visitors Authority. | What is the Boardwalk Hall? | {
"answer_start": [
83
],
"text": [
"an arena"
]
} |
5706de729e06ca38007e91cf | Atlantic_City,_New_Jersey | Boardwalk Hall, formally known as the "Historic Atlantic City Convention Hall", is an arena in Atlantic City along the boardwalk. Boardwalk Hall was Atlantic City's primary convention center until the opening of the Atlantic City Convention Center in 1997. The Atlantic City Convention Center includes 500,000 sq ft (46,000 m2) of showroom space, 5 exhibit halls, 45 meeting rooms with 109,000 sq ft (10,100 m2) of space, a garage with 1,400 parking spaces, and an adjacent Sheraton hotel. Both the Boardwalk Hall and Convention Center are operated by the Atlantic City Convention & Visitors Authority. | In what year did the newer Atlantic City Convention Center open? | {
"answer_start": [
251
],
"text": [
"1997"
]
} |
5706de729e06ca38007e91d0 | Atlantic_City,_New_Jersey | Boardwalk Hall, formally known as the "Historic Atlantic City Convention Hall", is an arena in Atlantic City along the boardwalk. Boardwalk Hall was Atlantic City's primary convention center until the opening of the Atlantic City Convention Center in 1997. The Atlantic City Convention Center includes 500,000 sq ft (46,000 m2) of showroom space, 5 exhibit halls, 45 meeting rooms with 109,000 sq ft (10,100 m2) of space, a garage with 1,400 parking spaces, and an adjacent Sheraton hotel. Both the Boardwalk Hall and Convention Center are operated by the Atlantic City Convention & Visitors Authority. | How many sq ft of showroom space is included in the Atlantic City Convention Center? | {
"answer_start": [
302
],
"text": [
"500,000 sq ft"
]
} |
5706de729e06ca38007e91d1 | Atlantic_City,_New_Jersey | Boardwalk Hall, formally known as the "Historic Atlantic City Convention Hall", is an arena in Atlantic City along the boardwalk. Boardwalk Hall was Atlantic City's primary convention center until the opening of the Atlantic City Convention Center in 1997. The Atlantic City Convention Center includes 500,000 sq ft (46,000 m2) of showroom space, 5 exhibit halls, 45 meeting rooms with 109,000 sq ft (10,100 m2) of space, a garage with 1,400 parking spaces, and an adjacent Sheraton hotel. Both the Boardwalk Hall and Convention Center are operated by the Atlantic City Convention & Visitors Authority. | What hotel is adjacent to the Atlantic City Convention Center? | {
"answer_start": [
474
],
"text": [
"Sheraton hotel"
]
} |
5706df8f90286e26004fc71d | Atlantic_City,_New_Jersey | Atlantic City (sometimes referred to as "Monopoly City") has become well-known over the years for its portrayal in the U.S. version of the popular board game, Monopoly, in which properties on the board are named after locations in and near Atlantic City. While the original incarnation of the game did not feature Atlantic City, it was in Indianapolis that Ruth Hoskins learned the game, and took it back to Atlantic City. After she arrived, Hoskins made a new board with Atlantic City street names, and taught it to a group of local Quakers. | What is Atlantic City sometimes referred to? | {
"answer_start": [
41
],
"text": [
"Monopoly City"
]
} |
5706df8f90286e26004fc71e | Atlantic_City,_New_Jersey | Atlantic City (sometimes referred to as "Monopoly City") has become well-known over the years for its portrayal in the U.S. version of the popular board game, Monopoly, in which properties on the board are named after locations in and near Atlantic City. While the original incarnation of the game did not feature Atlantic City, it was in Indianapolis that Ruth Hoskins learned the game, and took it back to Atlantic City. After she arrived, Hoskins made a new board with Atlantic City street names, and taught it to a group of local Quakers. | The names of many properties near Atlantic City are used in which popular board game? | {
"answer_start": [
159
],
"text": [
"Monopoly"
]
} |
5706df8f90286e26004fc71f | Atlantic_City,_New_Jersey | Atlantic City (sometimes referred to as "Monopoly City") has become well-known over the years for its portrayal in the U.S. version of the popular board game, Monopoly, in which properties on the board are named after locations in and near Atlantic City. While the original incarnation of the game did not feature Atlantic City, it was in Indianapolis that Ruth Hoskins learned the game, and took it back to Atlantic City. After she arrived, Hoskins made a new board with Atlantic City street names, and taught it to a group of local Quakers. | Who learned the game of Monopoly and took it to Atlantic City? | {
"answer_start": [
357
],
"text": [
"Ruth Hoskins"
]
} |
5706df8f90286e26004fc720 | Atlantic_City,_New_Jersey | Atlantic City (sometimes referred to as "Monopoly City") has become well-known over the years for its portrayal in the U.S. version of the popular board game, Monopoly, in which properties on the board are named after locations in and near Atlantic City. While the original incarnation of the game did not feature Atlantic City, it was in Indianapolis that Ruth Hoskins learned the game, and took it back to Atlantic City. After she arrived, Hoskins made a new board with Atlantic City street names, and taught it to a group of local Quakers. | What location was originally featured in the Monopoly game? | {
"answer_start": [
339
],
"text": [
"Indianapolis"
]
} |
5706df8f90286e26004fc721 | Atlantic_City,_New_Jersey | Atlantic City (sometimes referred to as "Monopoly City") has become well-known over the years for its portrayal in the U.S. version of the popular board game, Monopoly, in which properties on the board are named after locations in and near Atlantic City. While the original incarnation of the game did not feature Atlantic City, it was in Indianapolis that Ruth Hoskins learned the game, and took it back to Atlantic City. After she arrived, Hoskins made a new board with Atlantic City street names, and taught it to a group of local Quakers. | Who did Ruth Hoskins teach the game of Monopoly to? | {
"answer_start": [
517
],
"text": [
"a group of local Quakers"
]
} |
5706e5579e06ca38007e91fb | Atlantic_City,_New_Jersey | Marvin Gardens, the leading yellow property on the board shown, is actually a misspelling of the original location name, "Marven Gardens". The misspelling was said to have been introduced by Charles Todd and passed on when his home-made Monopoly board was copied by Charles Darrow and thence Parker Brothers. It was not until 1995 that Parker Brothers acknowledged this mistake and formally apologized to the residents of Marven Gardens for the misspelling although the spelling error was not corrected. | What popular property in Monopoly was actually a misspelling? | {
"answer_start": [
0
],
"text": [
"Marvin Gardens"
]
} |
5706e5579e06ca38007e91fc | Atlantic_City,_New_Jersey | Marvin Gardens, the leading yellow property on the board shown, is actually a misspelling of the original location name, "Marven Gardens". The misspelling was said to have been introduced by Charles Todd and passed on when his home-made Monopoly board was copied by Charles Darrow and thence Parker Brothers. It was not until 1995 that Parker Brothers acknowledged this mistake and formally apologized to the residents of Marven Gardens for the misspelling although the spelling error was not corrected. | What is the name of the original property that Marvin Gardens takes its name from? | {
"answer_start": [
122
],
"text": [
"Marven Gardens"
]
} |
5706e5579e06ca38007e91fd | Atlantic_City,_New_Jersey | Marvin Gardens, the leading yellow property on the board shown, is actually a misspelling of the original location name, "Marven Gardens". The misspelling was said to have been introduced by Charles Todd and passed on when his home-made Monopoly board was copied by Charles Darrow and thence Parker Brothers. It was not until 1995 that Parker Brothers acknowledged this mistake and formally apologized to the residents of Marven Gardens for the misspelling although the spelling error was not corrected. | Whose game did Parker Brothers model the board game after? | {
"answer_start": [
266
],
"text": [
"Charles Darrow"
]
} |
5706e5579e06ca38007e91fe | Atlantic_City,_New_Jersey | Marvin Gardens, the leading yellow property on the board shown, is actually a misspelling of the original location name, "Marven Gardens". The misspelling was said to have been introduced by Charles Todd and passed on when his home-made Monopoly board was copied by Charles Darrow and thence Parker Brothers. It was not until 1995 that Parker Brothers acknowledged this mistake and formally apologized to the residents of Marven Gardens for the misspelling although the spelling error was not corrected. | In what year did Parker Brothers acknowledge and apologize for a spelling error in the game? | {
"answer_start": [
326
],
"text": [
"1995"
]
} |
5706e5579e06ca38007e91ff | Atlantic_City,_New_Jersey | Marvin Gardens, the leading yellow property on the board shown, is actually a misspelling of the original location name, "Marven Gardens". The misspelling was said to have been introduced by Charles Todd and passed on when his home-made Monopoly board was copied by Charles Darrow and thence Parker Brothers. It was not until 1995 that Parker Brothers acknowledged this mistake and formally apologized to the residents of Marven Gardens for the misspelling although the spelling error was not corrected. | Who copied Charles Todd's Monopoly board? | {
"answer_start": [
266
],
"text": [
"Charles Darrow"
]
} |
57060dce52bb891400689816 | Immunology | Immunology is a branch of biomedical science that covers the study of immune systems in all organisms. It charts, measures, and contextualizes the: physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases, hypersensitivities, immune deficiency, and transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has applications in numerous disciplines of medicine, particularly in the fields of organ transplantation, oncology, virology, bacteriology, parasitology, psychiatry, and dermatology. | In general, what does immunology study? | {
"answer_start": [
70
],
"text": [
"immune systems in all organisms"
]
} |
57060dce52bb891400689817 | Immunology | Immunology is a branch of biomedical science that covers the study of immune systems in all organisms. It charts, measures, and contextualizes the: physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases, hypersensitivities, immune deficiency, and transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has applications in numerous disciplines of medicine, particularly in the fields of organ transplantation, oncology, virology, bacteriology, parasitology, psychiatry, and dermatology. | Immunology studies the functioning of the immune system in which two states of being? | {
"answer_start": [
208
],
"text": [
"both health and diseases"
]
} |
57060dce52bb891400689818 | Immunology | Immunology is a branch of biomedical science that covers the study of immune systems in all organisms. It charts, measures, and contextualizes the: physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases, hypersensitivities, immune deficiency, and transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has applications in numerous disciplines of medicine, particularly in the fields of organ transplantation, oncology, virology, bacteriology, parasitology, psychiatry, and dermatology. | Name three types of immunological disorders? | {
"answer_start": [
304
],
"text": [
"autoimmune diseases, hypersensitivities, immune deficiency, and transplant rejection"
]
} |
57060dce52bb891400689819 | Immunology | Immunology is a branch of biomedical science that covers the study of immune systems in all organisms. It charts, measures, and contextualizes the: physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases, hypersensitivities, immune deficiency, and transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has applications in numerous disciplines of medicine, particularly in the fields of organ transplantation, oncology, virology, bacteriology, parasitology, psychiatry, and dermatology. | Immunology studies the immune system in which three stages of existence? | {
"answer_start": [
487
],
"text": [
"in vitro, in situ, and in vivo"
]
} |
57060dce52bb89140068981a | Immunology | Immunology is a branch of biomedical science that covers the study of immune systems in all organisms. It charts, measures, and contextualizes the: physiological functioning of the immune system in states of both health and diseases; malfunctions of the immune system in immunological disorders (such as autoimmune diseases, hypersensitivities, immune deficiency, and transplant rejection); the physical, chemical and physiological characteristics of the components of the immune system in vitro, in situ, and in vivo. Immunology has applications in numerous disciplines of medicine, particularly in the fields of organ transplantation, oncology, virology, bacteriology, parasitology, psychiatry, and dermatology. | What disciplines in medicine have particularly strong immunology applications? | {
"answer_start": [
614
],
"text": [
"organ transplantation, oncology, virology, bacteriology, parasitology, psychiatry, and dermatology"
]
} |
57061a3352bb8914006898a4 | Immunology | Prior to the designation of immunity from the etymological root immunis, which is Latin for "exempt"; early physicians characterized organs that would later be proven as essential components of the immune system. The important lymphoid organs of the immune system are the thymus and bone marrow, and chief lymphatic tissues such as spleen, tonsils, lymph vessels, lymph nodes, adenoids, and liver. When health conditions worsen to emergency status, portions of immune system organs including the thymus, spleen, bone marrow, lymph nodes and other lymphatic tissues can be surgically excised for examination while patients are still alive. | The term immunology is derived from a Latin word that means what? | {
"answer_start": [
93
],
"text": [
"exempt"
]
} |
57061a3352bb8914006898a5 | Immunology | Prior to the designation of immunity from the etymological root immunis, which is Latin for "exempt"; early physicians characterized organs that would later be proven as essential components of the immune system. The important lymphoid organs of the immune system are the thymus and bone marrow, and chief lymphatic tissues such as spleen, tonsils, lymph vessels, lymph nodes, adenoids, and liver. When health conditions worsen to emergency status, portions of immune system organs including the thymus, spleen, bone marrow, lymph nodes and other lymphatic tissues can be surgically excised for examination while patients are still alive. | What are the major organs of the immune system? | {
"answer_start": [
272
],
"text": [
"thymus and bone marrow, and chief lymphatic tissues such as spleen, tonsils, lymph vessels, lymph nodes, adenoids, and liver"
]
} |
57061a3352bb8914006898a6 | Immunology | Prior to the designation of immunity from the etymological root immunis, which is Latin for "exempt"; early physicians characterized organs that would later be proven as essential components of the immune system. The important lymphoid organs of the immune system are the thymus and bone marrow, and chief lymphatic tissues such as spleen, tonsils, lymph vessels, lymph nodes, adenoids, and liver. When health conditions worsen to emergency status, portions of immune system organs including the thymus, spleen, bone marrow, lymph nodes and other lymphatic tissues can be surgically excised for examination while patients are still alive. | Who originally discovered these parts of the immune system? | {
"answer_start": [
102
],
"text": [
"early physicians"
]
} |
57061a3352bb8914006898a7 | Immunology | Prior to the designation of immunity from the etymological root immunis, which is Latin for "exempt"; early physicians characterized organs that would later be proven as essential components of the immune system. The important lymphoid organs of the immune system are the thymus and bone marrow, and chief lymphatic tissues such as spleen, tonsils, lymph vessels, lymph nodes, adenoids, and liver. When health conditions worsen to emergency status, portions of immune system organs including the thymus, spleen, bone marrow, lymph nodes and other lymphatic tissues can be surgically excised for examination while patients are still alive. | How do physicians study a patient's immune system organs in emergency situations? | {
"answer_start": [
572
],
"text": [
"surgically excised for examination while patients are still alive"
]
} |
57061a3352bb8914006898a8 | Immunology | Prior to the designation of immunity from the etymological root immunis, which is Latin for "exempt"; early physicians characterized organs that would later be proven as essential components of the immune system. The important lymphoid organs of the immune system are the thymus and bone marrow, and chief lymphatic tissues such as spleen, tonsils, lymph vessels, lymph nodes, adenoids, and liver. When health conditions worsen to emergency status, portions of immune system organs including the thymus, spleen, bone marrow, lymph nodes and other lymphatic tissues can be surgically excised for examination while patients are still alive. | Which portions of the immune system can be safely removed in these emergency cases? | {
"answer_start": [
496
],
"text": [
"thymus, spleen, bone marrow, lymph nodes and other lymphatic tissues"
]
} |
57061c5c52bb8914006898b8 | Immunology | Many components of the immune system are typically cellular in nature and not associated with any specific organ; but rather are embedded or circulating in various tissues located throughout the body. | The structure of immune system components can be described as what? | {
"answer_start": [
41
],
"text": [
"typically cellular in nature"
]
} |
57061c5c52bb8914006898b9 | Immunology | Many components of the immune system are typically cellular in nature and not associated with any specific organ; but rather are embedded or circulating in various tissues located throughout the body. | Are immune tissues typically fixed with specific organs usually? | {
"answer_start": [
74
],
"text": [
"not associated with any specific organ"
]
} |
57061c5c52bb8914006898ba | Immunology | Many components of the immune system are typically cellular in nature and not associated with any specific organ; but rather are embedded or circulating in various tissues located throughout the body. | What is one way the cellular structures of the immune system are housed in the body? | {
"answer_start": [
129
],
"text": [
"embedded"
]
} |
57061c5c52bb8914006898bb | Immunology | Many components of the immune system are typically cellular in nature and not associated with any specific organ; but rather are embedded or circulating in various tissues located throughout the body. | What is another way these tissues are housed within the body? | {
"answer_start": [
141
],
"text": [
"circulating"
]
} |
57061fb875f01819005e79c0 | Immunology | Classical immunology ties in with the fields of epidemiology and medicine. It studies the relationship between the body systems, pathogens, and immunity. The earliest written mention of immunity can be traced back to the plague of Athens in 430 BCE. Thucydides noted that people who had recovered from a previous bout of the disease could nurse the sick without contracting the illness a second time. Many other ancient societies have references to this phenomenon, but it was not until the 19th and 20th centuries before the concept developed into scientific theory. | Which two fields of study are associated with immunology? | {
"answer_start": [
48
],
"text": [
"epidemiology and medicine"
]
} |
57061fb875f01819005e79c1 | Immunology | Classical immunology ties in with the fields of epidemiology and medicine. It studies the relationship between the body systems, pathogens, and immunity. The earliest written mention of immunity can be traced back to the plague of Athens in 430 BCE. Thucydides noted that people who had recovered from a previous bout of the disease could nurse the sick without contracting the illness a second time. Many other ancient societies have references to this phenomenon, but it was not until the 19th and 20th centuries before the concept developed into scientific theory. | Immunology studies how which three areas impact one another? | {
"answer_start": [
111
],
"text": [
"the body systems, pathogens, and immunity"
]
} |
57061fb875f01819005e79c2 | Immunology | Classical immunology ties in with the fields of epidemiology and medicine. It studies the relationship between the body systems, pathogens, and immunity. The earliest written mention of immunity can be traced back to the plague of Athens in 430 BCE. Thucydides noted that people who had recovered from a previous bout of the disease could nurse the sick without contracting the illness a second time. Many other ancient societies have references to this phenomenon, but it was not until the 19th and 20th centuries before the concept developed into scientific theory. | When was the first written mention of immunity as it pertains to the body? | {
"answer_start": [
241
],
"text": [
"430 BCE"
]
} |
57061fb875f01819005e79c3 | Immunology | Classical immunology ties in with the fields of epidemiology and medicine. It studies the relationship between the body systems, pathogens, and immunity. The earliest written mention of immunity can be traced back to the plague of Athens in 430 BCE. Thucydides noted that people who had recovered from a previous bout of the disease could nurse the sick without contracting the illness a second time. Many other ancient societies have references to this phenomenon, but it was not until the 19th and 20th centuries before the concept developed into scientific theory. | Which Greek historian made that notation? | {
"answer_start": [
250
],
"text": [
"Thucydides"
]
} |
57061fb875f01819005e79c4 | Immunology | Classical immunology ties in with the fields of epidemiology and medicine. It studies the relationship between the body systems, pathogens, and immunity. The earliest written mention of immunity can be traced back to the plague of Athens in 430 BCE. Thucydides noted that people who had recovered from a previous bout of the disease could nurse the sick without contracting the illness a second time. Many other ancient societies have references to this phenomenon, but it was not until the 19th and 20th centuries before the concept developed into scientific theory. | When did immunology start to become codified as a scientific theory? | {
"answer_start": [
491
],
"text": [
"19th and 20th centuries"
]
} |
5706265075f01819005e79f6 | Immunology | The study of the molecular and cellular components that comprise the immune system, including their function and interaction, is the central science of immunology. The immune system has been divided into a more primitive innate immune system and, in vertebrates, an acquired or adaptive immune system. The latter is further divided into humoral (or antibody) and cell-mediated components. | What is the basic, primitive part of the immune system known as? | {
"answer_start": [
221
],
"text": [
"innate immune system"
]
} |
5706265075f01819005e79f7 | Immunology | The study of the molecular and cellular components that comprise the immune system, including their function and interaction, is the central science of immunology. The immune system has been divided into a more primitive innate immune system and, in vertebrates, an acquired or adaptive immune system. The latter is further divided into humoral (or antibody) and cell-mediated components. | Vertebrates also have what type of immune system component? | {
"answer_start": [
266
],
"text": [
"acquired or adaptive immune system"
]
} |
5706265075f01819005e79f8 | Immunology | The study of the molecular and cellular components that comprise the immune system, including their function and interaction, is the central science of immunology. The immune system has been divided into a more primitive innate immune system and, in vertebrates, an acquired or adaptive immune system. The latter is further divided into humoral (or antibody) and cell-mediated components. | What is one type of adaptive immune system component? | {
"answer_start": [
337
],
"text": [
"humoral (or antibody)"
]
} |
5706265075f01819005e79f9 | Immunology | The study of the molecular and cellular components that comprise the immune system, including their function and interaction, is the central science of immunology. The immune system has been divided into a more primitive innate immune system and, in vertebrates, an acquired or adaptive immune system. The latter is further divided into humoral (or antibody) and cell-mediated components. | Name the other type of adaptive immune system component? | {
"answer_start": [
363
],
"text": [
"cell-mediated"
]
} |
5706265075f01819005e79fa | Immunology | The study of the molecular and cellular components that comprise the immune system, including their function and interaction, is the central science of immunology. The immune system has been divided into a more primitive innate immune system and, in vertebrates, an acquired or adaptive immune system. The latter is further divided into humoral (or antibody) and cell-mediated components. | The total immune system is generally composed of what types of structures? | {
"answer_start": [
17
],
"text": [
"molecular and cellular components"
]
} |
57062eba75f01819005e7a3c | Immunology | The humoral (antibody) response is defined as the interaction between antibodies and antigens. Antibodies are specific proteins released from a certain class of immune cells known as B lymphocytes, while antigens are defined as anything that elicits the generation of antibodies ("anti"body "gen"erators). Immunology rests on an understanding of the properties of these two biological entities and the cellular response to both. | Humoral immunology involves the interaction of what two elements? | {
"answer_start": [
70
],
"text": [
"antibodies and antigens"
]
} |
57062eba75f01819005e7a3d | Immunology | The humoral (antibody) response is defined as the interaction between antibodies and antigens. Antibodies are specific proteins released from a certain class of immune cells known as B lymphocytes, while antigens are defined as anything that elicits the generation of antibodies ("anti"body "gen"erators). Immunology rests on an understanding of the properties of these two biological entities and the cellular response to both. | What are antibodies comprised of? | {
"answer_start": [
110
],
"text": [
"specific proteins"
]
} |
57062eba75f01819005e7a3e | Immunology | The humoral (antibody) response is defined as the interaction between antibodies and antigens. Antibodies are specific proteins released from a certain class of immune cells known as B lymphocytes, while antigens are defined as anything that elicits the generation of antibodies ("anti"body "gen"erators). Immunology rests on an understanding of the properties of these two biological entities and the cellular response to both. | What cells produce antibodies? | {
"answer_start": [
183
],
"text": [
"B lymphocytes"
]
} |
57062eba75f01819005e7a3f | Immunology | The humoral (antibody) response is defined as the interaction between antibodies and antigens. Antibodies are specific proteins released from a certain class of immune cells known as B lymphocytes, while antigens are defined as anything that elicits the generation of antibodies ("anti"body "gen"erators). Immunology rests on an understanding of the properties of these two biological entities and the cellular response to both. | The term "antigen" is rooted in what two words? | {
"answer_start": [
280
],
"text": [
"\"anti\"body \"gen\"erators"
]
} |
57062eba75f01819005e7a40 | Immunology | The humoral (antibody) response is defined as the interaction between antibodies and antigens. Antibodies are specific proteins released from a certain class of immune cells known as B lymphocytes, while antigens are defined as anything that elicits the generation of antibodies ("anti"body "gen"erators). Immunology rests on an understanding of the properties of these two biological entities and the cellular response to both. | Immunology is the study of what type of responses to antibodies and antigens? | {
"answer_start": [
402
],
"text": [
"cellular response"
]
} |
570632d275f01819005e7a74 | Immunology | Immunological research continues to become more specialized, pursuing non-classical models of immunity and functions of cells, organs and systems not previously associated with the immune system (Yemeserach 2010). | In the field of immunology, what aspect is becoming more specialized? | {
"answer_start": [
14
],
"text": [
"research"
]
} |
570632d275f01819005e7a75 | Immunology | Immunological research continues to become more specialized, pursuing non-classical models of immunity and functions of cells, organs and systems not previously associated with the immune system (Yemeserach 2010). | What new areas are immunologists studying with more frequency? | {
"answer_start": [
70
],
"text": [
"non-classical models of immunity"
]
} |
570632d275f01819005e7a76 | Immunology | Immunological research continues to become more specialized, pursuing non-classical models of immunity and functions of cells, organs and systems not previously associated with the immune system (Yemeserach 2010). | The latest research into newer aspects of immunology is focused on what three elements of the body? | {
"answer_start": [
120
],
"text": [
"cells, organs and systems"
]
} |
570632d275f01819005e7a77 | Immunology | Immunological research continues to become more specialized, pursuing non-classical models of immunity and functions of cells, organs and systems not previously associated with the immune system (Yemeserach 2010). | These three elements of the body are of new interest for what reason? | {
"answer_start": [
146
],
"text": [
"not previously associated with the immune system"
]
} |
5706a57852bb891400689b1a | Immunology | Clinical immunology is the study of diseases caused by disorders of the immune system (failure, aberrant action, and malignant growth of the cellular elements of the system). It also involves diseases of other systems, where immune reactions play a part in the pathology and clinical features. | The study of diseases caused by immune system disorders is called? | {
"answer_start": [
0
],
"text": [
"Clinical immunology"
]
} |
5706a57852bb891400689b1b | Immunology | Clinical immunology is the study of diseases caused by disorders of the immune system (failure, aberrant action, and malignant growth of the cellular elements of the system). It also involves diseases of other systems, where immune reactions play a part in the pathology and clinical features. | What are three problems of the immune system studied by clinical immunology? | {
"answer_start": [
87
],
"text": [
"failure, aberrant action, and malignant growth"
]
} |
5706a57852bb891400689b1c | Immunology | Clinical immunology is the study of diseases caused by disorders of the immune system (failure, aberrant action, and malignant growth of the cellular elements of the system). It also involves diseases of other systems, where immune reactions play a part in the pathology and clinical features. | Where can these three elements occur in the immune system? | {
"answer_start": [
141
],
"text": [
"cellular elements"
]
} |
5706a57852bb891400689b1d | Immunology | Clinical immunology is the study of diseases caused by disorders of the immune system (failure, aberrant action, and malignant growth of the cellular elements of the system). It also involves diseases of other systems, where immune reactions play a part in the pathology and clinical features. | What else does clinical immunology concern itself with? | {
"answer_start": [
192
],
"text": [
"diseases of other systems"
]
} |
5706a57852bb891400689b1e | Immunology | Clinical immunology is the study of diseases caused by disorders of the immune system (failure, aberrant action, and malignant growth of the cellular elements of the system). It also involves diseases of other systems, where immune reactions play a part in the pathology and clinical features. | Why does clinical immunology extend to those areas? | {
"answer_start": [
225
],
"text": [
"immune reactions play a part in the pathology and clinical features"
]
} |
5706aa0a75f01819005e7ce6 | Immunology | Other immune system disorders include various hypersensitivities (such as in asthma and other allergies) that respond inappropriately to otherwise harmless compounds. | What is a type of immune system disorder? | {
"answer_start": [
46
],
"text": [
"hypersensitivities"
]
} |
5706aa0a75f01819005e7ce7 | Immunology | Other immune system disorders include various hypersensitivities (such as in asthma and other allergies) that respond inappropriately to otherwise harmless compounds. | What are some examples of hypersensitivities? | {
"answer_start": [
77
],
"text": [
"asthma and other allergies"
]
} |
5706aa0a75f01819005e7ce8 | Immunology | Other immune system disorders include various hypersensitivities (such as in asthma and other allergies) that respond inappropriately to otherwise harmless compounds. | What characterizes a hypersensitivity? | {
"answer_start": [
110
],
"text": [
"respond inappropriately to otherwise harmless compounds."
]
} |
5706ac3452bb891400689b54 | Immunology | The most well-known disease that affects the immune system itself is AIDS, an immunodeficiency characterized by the suppression of CD4+ ("helper") T cells, dendritic cells and macrophages by the Human Immunodeficiency Virus (HIV). | What is the most famous immune system disease? | {
"answer_start": [
69
],
"text": [
"AIDS"
]
} |
5706ac3452bb891400689b55 | Immunology | The most well-known disease that affects the immune system itself is AIDS, an immunodeficiency characterized by the suppression of CD4+ ("helper") T cells, dendritic cells and macrophages by the Human Immunodeficiency Virus (HIV). | What kind of disease is AIDS? | {
"answer_start": [
75
],
"text": [
"an immunodeficiency"
]
} |
5706ac3452bb891400689b56 | Immunology | The most well-known disease that affects the immune system itself is AIDS, an immunodeficiency characterized by the suppression of CD4+ ("helper") T cells, dendritic cells and macrophages by the Human Immunodeficiency Virus (HIV). | Which types of cells are suppressed by AIDS? | {
"answer_start": [
131
],
"text": [
"CD4+ (\"helper\") T cells, dendritic cells and macrophages"
]
} |
5706ac3452bb891400689b57 | Immunology | The most well-known disease that affects the immune system itself is AIDS, an immunodeficiency characterized by the suppression of CD4+ ("helper") T cells, dendritic cells and macrophages by the Human Immunodeficiency Virus (HIV). | What virus specifically suppresses those cells? | {
"answer_start": [
195
],
"text": [
"Human Immunodeficiency Virus (HIV)"
]
} |
5706e1209e06ca38007e91d7 | Immunology | The body’s capability to react to antigen depends on a person's age, antigen type, maternal factors and the area where the antigen is presented. Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological responses are greatly suppressed. Once born, a child’s immune system responds favorably to protein antigens while not as well to glycoproteins and polysaccharides. In fact, many of the infections acquired by neonates are caused by low virulence organisms like Staphylococcus and Pseudomonas. In neonates, opsonic activity and the ability to activate the complement cascade is very limited. For example, the mean level of C3 in a newborn is approximately 65% of that found in the adult. Phagocytic activity is also greatly impaired in newborns. This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes are slow and have a reduced ATP production, which also limits the newborn's phagocytic activity. Although, the number of total lymphocytes is significantly higher than in adults, the cellular and humoral immunity is also impaired. Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate poorly and produce very small amounts of cytokines like IL-2, IL-4, IL-5, IL-12, and IFN-g which limits their capacity to activate the humoral response as well as the phagocitic activity of macrophage. B cells develop early during gestation but are not fully active. | What are the four factors that determine how the body reacts to an antigen? | {
"answer_start": [
55
],
"text": [
"person's age, antigen type, maternal factors and the area"
]
} |
5706e1209e06ca38007e91d8 | Immunology | The body’s capability to react to antigen depends on a person's age, antigen type, maternal factors and the area where the antigen is presented. Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological responses are greatly suppressed. Once born, a child’s immune system responds favorably to protein antigens while not as well to glycoproteins and polysaccharides. In fact, many of the infections acquired by neonates are caused by low virulence organisms like Staphylococcus and Pseudomonas. In neonates, opsonic activity and the ability to activate the complement cascade is very limited. For example, the mean level of C3 in a newborn is approximately 65% of that found in the adult. Phagocytic activity is also greatly impaired in newborns. This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes are slow and have a reduced ATP production, which also limits the newborn's phagocytic activity. Although, the number of total lymphocytes is significantly higher than in adults, the cellular and humoral immunity is also impaired. Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate poorly and produce very small amounts of cytokines like IL-2, IL-4, IL-5, IL-12, and IFN-g which limits their capacity to activate the humoral response as well as the phagocitic activity of macrophage. B cells develop early during gestation but are not fully active. | Why are newborns described as being physiologically immunodeficient? | {
"answer_start": [
223
],
"text": [
"both their innate and adaptive immunological responses are greatly suppressed"
]
} |
5706e1209e06ca38007e91d9 | Immunology | The body’s capability to react to antigen depends on a person's age, antigen type, maternal factors and the area where the antigen is presented. Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological responses are greatly suppressed. Once born, a child’s immune system responds favorably to protein antigens while not as well to glycoproteins and polysaccharides. In fact, many of the infections acquired by neonates are caused by low virulence organisms like Staphylococcus and Pseudomonas. In neonates, opsonic activity and the ability to activate the complement cascade is very limited. For example, the mean level of C3 in a newborn is approximately 65% of that found in the adult. Phagocytic activity is also greatly impaired in newborns. This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes are slow and have a reduced ATP production, which also limits the newborn's phagocytic activity. Although, the number of total lymphocytes is significantly higher than in adults, the cellular and humoral immunity is also impaired. Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate poorly and produce very small amounts of cytokines like IL-2, IL-4, IL-5, IL-12, and IFN-g which limits their capacity to activate the humoral response as well as the phagocitic activity of macrophage. B cells develop early during gestation but are not fully active. | Newborns are particularly susceptible to infections caused by? | {
"answer_start": [
499
],
"text": [
"low virulence organisms like Staphylococcus and Pseudomonas"
]
} |
5706e1209e06ca38007e91da | Immunology | The body’s capability to react to antigen depends on a person's age, antigen type, maternal factors and the area where the antigen is presented. Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological responses are greatly suppressed. Once born, a child’s immune system responds favorably to protein antigens while not as well to glycoproteins and polysaccharides. In fact, many of the infections acquired by neonates are caused by low virulence organisms like Staphylococcus and Pseudomonas. In neonates, opsonic activity and the ability to activate the complement cascade is very limited. For example, the mean level of C3 in a newborn is approximately 65% of that found in the adult. Phagocytic activity is also greatly impaired in newborns. This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes are slow and have a reduced ATP production, which also limits the newborn's phagocytic activity. Although, the number of total lymphocytes is significantly higher than in adults, the cellular and humoral immunity is also impaired. Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate poorly and produce very small amounts of cytokines like IL-2, IL-4, IL-5, IL-12, and IFN-g which limits their capacity to activate the humoral response as well as the phagocitic activity of macrophage. B cells develop early during gestation but are not fully active. | What activity is also greatly reduced in newborn infants? | {
"answer_start": [
1110
],
"text": [
"phagocytic"
]
} |
5706e1209e06ca38007e91db | Immunology | The body’s capability to react to antigen depends on a person's age, antigen type, maternal factors and the area where the antigen is presented. Neonates are said to be in a state of physiological immunodeficiency, because both their innate and adaptive immunological responses are greatly suppressed. Once born, a child’s immune system responds favorably to protein antigens while not as well to glycoproteins and polysaccharides. In fact, many of the infections acquired by neonates are caused by low virulence organisms like Staphylococcus and Pseudomonas. In neonates, opsonic activity and the ability to activate the complement cascade is very limited. For example, the mean level of C3 in a newborn is approximately 65% of that found in the adult. Phagocytic activity is also greatly impaired in newborns. This is due to lower opsonic activity, as well as diminished up-regulation of integrin and selectin receptors, which limit the ability of neutrophils to interact with adhesion molecules in the endothelium. Their monocytes are slow and have a reduced ATP production, which also limits the newborn's phagocytic activity. Although, the number of total lymphocytes is significantly higher than in adults, the cellular and humoral immunity is also impaired. Antigen-presenting cells in newborns have a reduced capability to activate T cells. Also, T cells of a newborn proliferate poorly and produce very small amounts of cytokines like IL-2, IL-4, IL-5, IL-12, and IFN-g which limits their capacity to activate the humoral response as well as the phagocitic activity of macrophage. B cells develop early during gestation but are not fully active. | Antigen cells in newborns are also struggle to do this? | {
"answer_start": [
1331
],
"text": [
"activate T cells"
]
} |
5706e36d9e06ca38007e91e1 | Immunology | Maternal factors also play a role in the body’s immune response. At birth, most of the immunoglobulin present is maternal IgG. Because IgM, IgD, IgE and IgA don’t cross the placenta, they are almost undetectable at birth. Some IgA is provided by breast milk. These passively-acquired antibodies can protect the newborn for up to 18 months, but their response is usually short-lived and of low affinity. These antibodies can also produce a negative response. If a child is exposed to the antibody for a particular antigen before being exposed to the antigen itself then the child will produce a dampened response. Passively acquired maternal antibodies can suppress the antibody response to active immunization. Similarly the response of T-cells to vaccination differs in children compared to adults, and vaccines that induce Th1 responses in adults do not readily elicit these same responses in neonates. Between six to nine months after birth, a child’s immune system begins to respond more strongly to glycoproteins, but there is usually no marked improvement in their response to polysaccharides until they are at least one year old. This can be the reason for distinct time frames found in vaccination schedules. | In babies, what is another element impacting immune response? | {
"answer_start": [
0
],
"text": [
"Maternal factors"
]
} |
5706e36d9e06ca38007e91e2 | Immunology | Maternal factors also play a role in the body’s immune response. At birth, most of the immunoglobulin present is maternal IgG. Because IgM, IgD, IgE and IgA don’t cross the placenta, they are almost undetectable at birth. Some IgA is provided by breast milk. These passively-acquired antibodies can protect the newborn for up to 18 months, but their response is usually short-lived and of low affinity. These antibodies can also produce a negative response. If a child is exposed to the antibody for a particular antigen before being exposed to the antigen itself then the child will produce a dampened response. Passively acquired maternal antibodies can suppress the antibody response to active immunization. Similarly the response of T-cells to vaccination differs in children compared to adults, and vaccines that induce Th1 responses in adults do not readily elicit these same responses in neonates. Between six to nine months after birth, a child’s immune system begins to respond more strongly to glycoproteins, but there is usually no marked improvement in their response to polysaccharides until they are at least one year old. This can be the reason for distinct time frames found in vaccination schedules. | Newborns can acquire antibodies from the mother through what means? | {
"answer_start": [
246
],
"text": [
"breast milk"
]
} |
5706e36d9e06ca38007e91e3 | Immunology | Maternal factors also play a role in the body’s immune response. At birth, most of the immunoglobulin present is maternal IgG. Because IgM, IgD, IgE and IgA don’t cross the placenta, they are almost undetectable at birth. Some IgA is provided by breast milk. These passively-acquired antibodies can protect the newborn for up to 18 months, but their response is usually short-lived and of low affinity. These antibodies can also produce a negative response. If a child is exposed to the antibody for a particular antigen before being exposed to the antigen itself then the child will produce a dampened response. Passively acquired maternal antibodies can suppress the antibody response to active immunization. Similarly the response of T-cells to vaccination differs in children compared to adults, and vaccines that induce Th1 responses in adults do not readily elicit these same responses in neonates. Between six to nine months after birth, a child’s immune system begins to respond more strongly to glycoproteins, but there is usually no marked improvement in their response to polysaccharides until they are at least one year old. This can be the reason for distinct time frames found in vaccination schedules. | For how long do these antibodies have an effect on infants? | {
"answer_start": [
323
],
"text": [
"up to 18 months"
]
} |
5706e36d9e06ca38007e91e4 | Immunology | Maternal factors also play a role in the body’s immune response. At birth, most of the immunoglobulin present is maternal IgG. Because IgM, IgD, IgE and IgA don’t cross the placenta, they are almost undetectable at birth. Some IgA is provided by breast milk. These passively-acquired antibodies can protect the newborn for up to 18 months, but their response is usually short-lived and of low affinity. These antibodies can also produce a negative response. If a child is exposed to the antibody for a particular antigen before being exposed to the antigen itself then the child will produce a dampened response. Passively acquired maternal antibodies can suppress the antibody response to active immunization. Similarly the response of T-cells to vaccination differs in children compared to adults, and vaccines that induce Th1 responses in adults do not readily elicit these same responses in neonates. Between six to nine months after birth, a child’s immune system begins to respond more strongly to glycoproteins, but there is usually no marked improvement in their response to polysaccharides until they are at least one year old. This can be the reason for distinct time frames found in vaccination schedules. | At 6 to 9 months, an infant's immune system begins to respond to which proteins? | {
"answer_start": [
1004
],
"text": [
"glycoproteins"
]
} |
5706e36d9e06ca38007e91e5 | Immunology | Maternal factors also play a role in the body’s immune response. At birth, most of the immunoglobulin present is maternal IgG. Because IgM, IgD, IgE and IgA don’t cross the placenta, they are almost undetectable at birth. Some IgA is provided by breast milk. These passively-acquired antibodies can protect the newborn for up to 18 months, but their response is usually short-lived and of low affinity. These antibodies can also produce a negative response. If a child is exposed to the antibody for a particular antigen before being exposed to the antigen itself then the child will produce a dampened response. Passively acquired maternal antibodies can suppress the antibody response to active immunization. Similarly the response of T-cells to vaccination differs in children compared to adults, and vaccines that induce Th1 responses in adults do not readily elicit these same responses in neonates. Between six to nine months after birth, a child’s immune system begins to respond more strongly to glycoproteins, but there is usually no marked improvement in their response to polysaccharides until they are at least one year old. This can be the reason for distinct time frames found in vaccination schedules. | The difference in responses in infant immune systems is the cause of what? | {
"answer_start": [
1164
],
"text": [
"distinct time frames found in vaccination schedules"
]
} |
5706e5b49e06ca38007e9205 | Immunology | During adolescence, the human body undergoes various physical, physiological and immunological changes triggered and mediated by hormones, of which the most significant in females is 17-β-oestradiol (an oestrogen) and, in males, is testosterone. Oestradiol usually begins to act around the age of 10 and testosterone some months later. There is evidence that these steroids act directly not only on the primary and secondary sexual characteristics but also have an effect on the development and regulation of the immune system, including an increased risk in developing pubescent and post-pubescent autoimmunity. There is also some evidence that cell surface receptors on B cells and macrophages may detect sex hormones in the system. | What is the primary trigger for immunological changes in teens? | {
"answer_start": [
129
],
"text": [
"hormones"
]
} |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.