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Tumor necrosis factor-alpha/cachectin activates the O2(-)-generating system of human neutrophils independently of the hydrolysis of phosphoinositides and the release of arachidonic acid.
We have investigated the mechanisms of transmembrane signalling implicated in the activation of the respiratory burst of adherent neutrophils by tumor necrosis factor-alpha/cachectin (TNF). The activation of the respiratory burst by TNF is insensitive to pertussis toxin and weakly sensitive to protein kinase C inhibitors. Cytochalasin B and dibutyryl cyclic AMP have an inhibitory effect. The activation of the respiratory burst by TNF takes place in the absence of formation of 3H-inositol phosphates, 32P-phosphatidic acid, and 3H-arachidonic acid. These results demonstrate that the activation of the respiratory burst by an endogenous, physiologic stimulus can be independent of the formation of messengers derived from hydrolysis of phosphoinositides. |
Deane, who is speaking at the Lawyers’ Guide to the Media summit next month in Glasgow, said: “There is a perception that the press will stitch you up. So rather than speak to a journalist a lawyer will advise a client to put out a statement or not make a statement at all.” |
Bli en del av äventyret
I år öppnar vi upp våra arenor för våra besökare. På grund av rådande restriktioner ersätts våra ordinarie shower med interaktiva och äventyrsbaserad upplevelser med våra karaktärer under hela dagen i hela parken. Läs mer här.
I år har du och hela familjen verkligen chans att bli en del av äventyret på High Chaparral. |
*JQuery-UI
dialog
"Make the selected elements Dialog boxes."
^ self create: JQDialog |
Much has been made recently about the supposed economic recovery. A few blips in a few statistics and many believe our troubles are all over. Of course, they have to redefine recovery as "jobless" to account for the lack of improvement on Main Street. But the banks have money, Wall Street is chugging along, and the administration would like to get on with other agendae.
They have even set up a commission to investigate the crisis as if it were all in the past.
The truth is that Americans are still losing jobs, the Fed is still inflating, and more regulations are in the works that will prevent jobs and productivity from coming back. We are on this trajectory for the long haul. The claim has been made many times that this administration has only had a year to clean up the mess of the last administration. I wish they would at least get started! Instead of reversing course, they are maintaining Bush's policies full speed ahead. They are even keeping the Bush-appointee in charge of the Federal Reserve! They are not even making token efforts at change in economic policy. And for all the talk of transparency, we hear that some powerful senators will do all they can to block a simple audit of the powerful and secretive Federal Reserve.
We have been on a disastrous course for a long time. The money supply has doubled in the last year, our debt is unsustainable, the value of the dollar is going to continue its drop, and those Americans who understand where we are headed feel helpless and held hostage by foolish policy makers in Washington. When the bills finally come due and the dollar stops working we are in for some real social, economic and political chaos. That is, unless we take some major steps now to allow for a peaceful transition in the future. These steps are laid out in my legislation to legalize competing currencies.
First of all, no one should be compelled by law to operate in Federal Reserve notes if they prefer an alternative. We should repeal legal tender laws and allow Americans to conduct transactions in constitutional money. Only gold and silver can constitutionally be legal tender, not paper money. Instead, it is illegal to conduct business using gold and silver instead of Federal Reserve notes. Simply legalizing the Constitution should be a no-brainer to anyone who took an oath of office. Consequently, private mints should be allowed to mint gold and silver coins. They would be subject to fraud and counterfeit laws, of course, and people would be free to use their coins or stay with Federal Reserve notes, as they see fit. Finally, we should abolish taxes on gold and silver, which puts precious metals at a competitive disadvantage to paper money.
The Federal Reserve is a government-sanctioned banking cartel that has held far too much power for far too long and is in the end stages of running the dollar into the ground, and our economy along with it. The very least Congress can do, if they are not willing to abolish the Fed, and perhaps not even conduct a serious audit of it, is to allow citizens the freedom to defend themselves from being completely wiped out by their monopoly power. |
Q:
Preterite perfects with a doubly remote intrepretation
If they had gone tomorrow they would have met her son. I’d rather
you had gone tomorrow.
-- The Cambridge Grammar of the English Language
I have familiarity with temporal anteriority of perfect tense, but not with the perfect above. The book says they are doubly remote with future time. It seems like it says the preterite expresses modal remoteness and the perfect makes further remoteness, and so they call it doubly remote construction. It amazes me that perfect tense makes time distance not backward but forward for making psychological remoteness.
Do you really make psychological distance by using preterite prefect with future time, or is it just an imaginary possibility?
A:
You seem to be misreading slightly.
It seems like it says the preterite expresses modal remoteness and the perfect makes further remoteness, and so they call it doubly remote construction.
Yes. In both of your examples, CGEL makes the point that the doubly remote construction is necessarily counterfactual ("If they had gone tomorrow" necessarily means "they're not going tomorrow", perhaps because they already went yesterday, and "I'd rather you had gone tomorrow" necessarily means "you're not going tomorrow"); whereas with the preterite alone, as in "If they went tomorrow" and "I'd rather you went tomorrow", they wouldn't necessarily be counterfactual. (However, CGEL also gives some present-time examples where the doubly remote construction is not necessarily counterfactual.)
It amazes me that perfect tense makes time distance not backward but forward for making psychological remoteness.
No. The remoteness here is not the remoteness of future time; after all, CGEL says this construction can occur "with present and future time" (emphasis mine), and explains in a footnote that "The double remote construction is not available for past time because the perfect construction is not recursive"; that is, the reason you can use the doubly remote construction with present and future time, but not with past time, is that with past time the perfect is already being used to express anteriority, so it can't be re-used to express remoteness (since *"if they had had gone yesterday" is ungrammatical).
|
Q:
Find the nodes in the percona cluster
How do I find the number of nodes and node ip addresses in the Percona XtraDB cluster from inside a Python application? I know the IP address of one node in the cluster.
A:
This can be done by executing
show variables like 'wsrep_cluster_address';
For example using sqlalchemy, you can do this by:
engine.execute("SHOW VARIABLES LIKE 'wsrep_cluster_address'").fetchone()
|
Response to Sam Adams' JTTF Proposal
A clear analysis of major problems in Mayor Sam Adams' JTTF proposal.
The draft JTTF resolution does a very good job trying to balance the interests of FBI with local interests in the abstract given that proposal choses to entangle the PPB with the JTTF once again. It is a really tremendous first effort and shows its roots in the diversity, creativity and populism of Portland and the Mayor's office. Certainly, a proposal not to coordinate with the JTTF except to receive information would be the more wise choice for safety and privacy of our citizens. Notwithstanding the poor choice to engage with the JTTF at all, there are several fatal flaws in the proposal as it stands which will ultimately fail again to protect the civil rights and liberties of Portland and Oregon citizens. Unfortunately, the proposal in its current form amounts to a return to business as usual for the PPB and JTTF. This draft is just the a kinder, gentler Old Emperor in new clothes that are not so transparent. |
Q:
Do I even need `-pedantic` if I specify the standard to ANSI C with `-std=c89`?
If I specify the standard to ANSI C with -std=c89, my code won't run until I perform certain changes to make it compliant with the standard. So do I even need -pedantic at this point if I've already set the -std=c89 flag?
By the way, the idea was to write C code which is as platform independet as possible. I was already using -pedantic as I knew it would make the compiler more strict. However, it also made sense to explicitly choose the ANSI C standard. For some reason I thought this would make -pedantic superfluous because the switch to ANSI C produced many errors in itself and appeared "strict enough".
A:
No, even though both -pedantic and -std=c89 might individually cause your code to fail to compile, they don't do the same thing:
-std=c89 will tell the compiler which ISO standard to use (in this case ANSI C also known as C89 or C90)
-pedantic will tell the compiler how strict the chosen standard should be enforced
You can also find the following helpful hint in the man page. -std=c89 is equivalent to -ansi for which man gcc says:
The -ansi option does not cause non-ISO programs to be rejected gratuitously. For that, -pedantic is required in addition to -ansi.
|
Global transcriptional analysis of Bacillus licheniformis reveals an overlap between heat shock and iron limitation stimulon.
In this study, we characterized the heat shock stimulon of the important industrial microorganism Bacillus licheniformis using DNA microarrays. While sharing a high degree of homology with the closely related model organism Bacillus subtilis, the heat shock stimulon of B. licheniformis exhibited several novel and unexpected features. Most notably, heat shock in B. licheniformis resulted in decreased amounts of mRNA from the ytrABCEF operon, encoding a putative acetoin uptake system, and stimulated the transcription of purine biosynthesis and iron uptake genes. Unexpectedly, deletion of the ytrEF genes did not affect acetoin uptake, but increased heat sensitivity. To investigate the connection between heat stress and iron uptake further, we analyzed the iron limitation response of B. licheniformis by DNA microarrays and concluded that the response mostly involves the genes related to iron uptake and metabolism, while the only heat shock gene affected by iron limitation was clpE. We also attempted to delete the fur gene (encoding the ferric uptake repressor), but unexpectedly found it to be essential in B. licheniformis. Using the fluorescent protein-encoding reporter gene under control of the dhb promoter, which responded to both heat shock and iron-starvation, we confirmed the overlap between these responses. |
Hand tooled latigo leather straps represent the highest expression of leather artistry. We painstakingly designed these straps to combine our signature Franklin end tab with patterns that display the leather worker’s craft. The latigo is backed with a cushion of foam that is wrapped in ultra soft leather. The sides are then hand – treated and polished for a lustrous finish. Two unique die patterns were created for the cutouts; a western inspired style and a stylized flame graphic. Richly pebbled leather, supple suede or elegant snakeskin are then inlaid and finished off with a silver concho for a stunning visual effect. |
Abstract
Digital human modelling (DHM) is discussed as a design tool in the context of user-centred design, with a focus on DHM usage for anthropometric analysis in occupant packaging tasks in the vehicle interior design process. References are made to concepts of inclusive design, user-centred design, design cognition and design methodology. Examples are presented to illustrate how DHM can be of great use to the vehicle designer, but also to show some of the difficulties involved. This includes the complexity in considering anthropometric variation of the targeted product users in multivariate design problems, such as the design of vehicle interiors and suggestions on how to deal with this difficulty in an industrial design setting. Overall, the paper takes a designer's view of DHM tools and illustrates how the tools can be of value in the design process, but also considers what implications this has on the functionality and usability of the tools. |
Electron microscopic localization of cholinesterase activity in Alzheimer brain tissue.
Acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity was localized by electron microscopic enzyme cytochemistry in cortex from Alzheimer brains and brains from non-demented cases. In the tangle-rich medial temporal cortex of the Alzheimer brain, most of the neuronal AChE was associated with neurofibrillary tangles. These structures also contained BChE activity. In normal neurons AChE activity was found in the rough endoplasmic reticulum, nuclear envelope and Golgi apparatus. Little BChE activity was noted in normal cortex. In neuritic plaques, AChE and BChE activity was associated mostly with the amyloid, but also with the neuritic component. |
Inhibition of invasion-associated thromboxane synthase sensitizes experimental gliomas to gamma-radiation.
The invasion- and apoptosis-associated thromboxane synthase gene encoding an enzyme of the arachidonic acid pathway has been implicated in glioma progression. Furegrelate, a specific inhibitor of thromboxane synthase, blocks cell motility, induces apoptosis and increases sensitivity to drug induced apoptosis in human glioma cells in vitro. The impact of furegrelate on the sensitivity of human glioma cells to gamma-irradiation was analyzed using colony formation assay in vitro and an orthotopic mouse model in vivo. Pre-treatment of glioma cells with furegrelate increases radiation sensitivity of cultured glioma cells. Treatment of experimental gliomas with suboptimal doses of radiation and furegrelate results in a significant decrease in tumor volumes compared to untreated controls. Thus, the specific thromboxane synthase inhibitor furegrelate increases death response induced by gamma-radiation in glioma cells in vitro and sensitizes experimental gliomas to radiation treatment in vivo. |
Massapequa Invasion U15 girls soccer team took first place at a tournament held Columbus Day weekend. The girls challenged themselves playing in a U16 league in the Lehigh Tournament in Pennsylvania. More... |
[
{
"category": "``cognito-idp``",
"description": "Update cognito-idp command to latest version",
"type": "api-change"
},
{
"category": "``lambda``",
"description": "Update lambda command to latest version",
"type": "api-change"
}
] |
I trusted you. I had never trusted anyone before you. I gave you the power to hurt me, and painfully, you used that power against me at full force. I fell to my knees, a broken and shattered shell of who I once was. And I lay there, weak... open to all the harshness of the world without the common comfort of being able to find that peace of mind within one's self. And as time passed, I thank God that you realized the error in your ways. I do appreciate this protection you provide and your efforts to mend my heart, but I'm afraid it's a fruitless cause, because I'll never be whole again. You still have that piece of me that you can never return or replace.
~He's the cutest, sweetest, nicest, greatest, most romantic, most insensitive jerk I have ever met~
Don't ever say you love me, unless you mean it. Because I might do somethin dumb... like believe it.
Just because two people argue doesn't mean they don't love each other. And just because they don't argue, doesn't mean they do.
I'm frustrated, cause I can't tell if it's real Mad, cause I dunno how you feel Upset, cause we can't make things right Sad, cause I need you, day and night Angry, cause you won't take my hand Crying, cause you don't understand Hurt, cause we're not together And I'll love you now, until forever.
I love him yes i do he's for me and not for you, if by chance you take my place, I'll take my fist and smash your face.
~*Sometimes i wonder who he's picturing when he looks at me and smiles.
~*I know you loved me. I loved the fact that you loved me so much. There's this sense of security in someone's love. I let you go and i hate myself for doing that, but thats all in the past. Maybe leaving was a test to see how true your love was and now it's all starting to slip away from me. I know you still love me. I hope you still love me because when i look in your eyes i know i can't turn away anymore. This is where i have to be. You are who i love and i can't change anything that happened in the past. I love you. I always have.
~*You said you would always be there for me. I guess we have a difference in our definitions of always.
~*I know i'm crazy about someone when i take a longer way to class...even if it means climbing an extra set of stairs, just to walk by him.
~*I can live without you, i just don't want to.
~*I'm not a child anymore. I'm tall enough to reach for the stars. I'm old enough to love you from afar. Too trusting? Yes. But then, women usually are.
~*I am not the kind of girl who thinks a guy is the answer to everything...i'm just tired of being alone.
~*'Tell me, is it the possibilty of losing him to somebody else that suddenly makes him seem so attractive?' 'You really think i'm that shallow huh?' 'No, i think you're that human.'
~*Snow White. Cinderella. All about wanting a guy, being saved by the guy. Today it's Little Mermaid, Aladdin, Pocahontas. All about getting a guy. So basically we're screwed up because of Disney.
~*"Why is it that when you miss someone so much that your heart is ready to disinegrate that you hear the saddest song on the radio?"~Pete and Pete
~*He loves me, he loves me not. Either way my heart's been caught.
~*Starlight starbrite where the hell is mr.right?
~*"Nothing's true and nothing's right. So let me be alone tonight. You can't change the way i am. Are you strong enough to be my man?"~
~*Love is like grass. If you fall on it, it may leave a stain and some temporary pain. But you'll get over the pain, it will eventually stop hurting. Now maybe the stain ruined your favorite pair of jeans, or maybe it was nothing special that was ruined, but either way the stain remains there. And with time it will begin to fade, but it will always be there, a permanent reminder that you, too, once fell.
~*Relationships are very simple. There are only two things that can happen. You either get married or your break up.
~*Do you see her face? Girls like that are born with a boyfriend.
~*Love is like some cosmic practical joke that someone up there with absolutely no sense of humor thinks is funny. |
...
her. We were lucky to have a number of different perspectives on this. Gary in particular had been working with her recently and had an interesting story to tell.From an interesting story to a frankly bizarre one. We're used to better together prophecies of financial doom or some such other thing, but George Robertson took it on himself to make a prediction of actual apocalyptic doom should Scotland go independent, with the Forces of Darkness being unleashed (artists rendition above).This forced us to bring our own big guns out and so we got to it. In fact we unleashed our dogs of war, with grave consequences for Andrew.Vonny had some interesting comments on the importance of language in the whole debate, and we also put our heads together to try and predict where the next scare story could possibly go - have they run out or have they used them all up too fast?There's much more besides in the latest episode, and I haven't even mentioned Douglas Adams in the introduction either.Hope you enjoy (and if you feel up to helping us along with our running costs you can pop us a donation too.)LINKS |
_____________________________________________________________________________
"Progression is the engine that drives growth" -IronWill
"To see a World in a Grain of Sand
And a Heaven in a Wild Flower,
Hold Infinity in the palm of your hand
And Eternity in an hour.
..."
-William Blake
_____________________________________________________________________________ |
Muslim Vashikaran Specialist And Muslim Vashikaran Mantra For Love
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Welcome to Miyan Islam Khan ji website who is gifted for people who want to solve their love problem,family problem,husband wife dispute problem,love lost problem,break up solution or any other problem solution by muslim astrology it is the right platform for you all You are just one call away for solution of your problem. |
A proposed client self-care commitment model.
Expansion of the dental hygiene body of knowledge offers options for the profession; evolving conceptual models allow practitioners to choose an approach to client care that is scientifically sound yet matches individual philosophies. Health paradigms for different approaches to client care have been developed and used in medical anthropology, psychology, and dental hygiene. Adapted from the biomedical model, the explanatory model, the empowerment model, and the human needs conceptual model, a new model for client commitment is proposed. The client self-care commitment model is composed of five domains: initiation, assessment, negotiation, commitment, and evaluation. This model proposes that the relationships among these domains, and the interaction between the client and the dental hygienist can empower clients to make decisions that will enhance their own health through commitment and compliance. This paper reviews the scientific literature from medical anthropology, psychology, and dental hygiene that focus on client care, and suggests possible applications of the model to the dental hygiene process of care, dental hygiene education, and qualitative research. |
package com.googlecode.totallylazy.io;
import com.googlecode.totallylazy.Sequence;
import com.googlecode.totallylazy.Unchecked;
import com.googlecode.totallylazy.functions.Unary;
import java.io.IOException;
import java.io.InputStream;
import java.util.Date;
import java.util.zip.ZipInputStream;
import static com.googlecode.totallylazy.io.FilterSource.filterSource;
import static com.googlecode.totallylazy.predicates.Predicates.*;
public class ZipSource implements Sources {
final ZipInputStream in;
private ZipSource(InputStream inputStream) {
in = inputStream instanceof ZipInputStream ? Unchecked.<ZipInputStream>cast(inputStream) : new ZipInputStream(inputStream);
}
public static ZipSource zipSource(InputStream inputStream) {
return new ZipSource(inputStream);
}
public static Sources zipSource(InputStream inputStream, String rawFolder) {
String folder = rawFolder.replaceFirst("/", "");
return filterSource(where(Source::name, is(not(""))),
MapSources.mapSource(removeFolderFromName(folder),
filterSource(source -> source.name().startsWith(folder), zipSource(inputStream))));
}
private static Unary<Source> removeFolderFromName(final String folder) {
return source -> Source.source(source.name().replaceFirst("^" + folder, ""), source::modified, source::input, source.isDirectory());
}
@Override
public Sequence<Source> sources() {
return Zip.entries(in).map(zipEntry -> Source.source(zipEntry.getName(), () -> new Date(zipEntry.getTime()), IgnoreCloseInputStream::new, zipEntry.isDirectory()));
}
@Override
public void close() throws IOException {
in.close();
}
private class IgnoreCloseInputStream extends InputStream {
@Override
public int read() throws IOException {
return in.read();
}
@Override
public int read(byte[] b) throws IOException {
return in.read(b);
}
@Override
public int read(byte[] b, int off, int len) throws IOException {
return in.read(b, off, len);
}
}
}
|
Integration of XAS techniques and genetic methodologies to explore Cs-tolerance in Arabidopsis.
We have characterised genetically and phenotypically a T-DNA insertion mutant line of A. thaliana (L.) Heynh. selected for Cs resistance when germinating and growing on Cs concentrations up to 600microM, lethal for the wild type. Measures of concentration and localisation of Cs, K, and Ca have been conducted on plants grown in vivo also utilising synchrotron light-based techniques as micro-SRXF (synchrotron radiation induced X-ray micro-fluorescence) and micro-XANES (micro X-ray absorption near edge structure) spectroscopy. We report here an attempt to apply micro-XANES to investigate Cs speciation and to measure the Cs content of living plants. The results obtained with micro-SRXF and micro-XANES spectroscopy complemented the genetic and physiological analyses: a comparison between wild type and mutant plants led to the conclusion that in our case a single gene mutation impairs Cs uptake and translocation, K and Ca homeostasis and plant biomass production. |
The United States of Mind: Researchers Identify Regional Personality Traits Across America - robg
http://online.wsj.com/article/SB122211987961064719.html?mod=yhoofront#articleTabs_interactive-PERSONALITY08%26project%3DPERSONALITY08
======
river_styx
Alaskans have no personality at all, it seems.
|
The idea of creating a collage comprised of many different elements is what drove the design of the Umbra Montage Wall Multi-frame. A collection of vintage-inspired frames houses photos of assorted sizes, creating a truly alluring appeal. And if that isn't enough, a molded bird and ampersand symbol bring extra charm to the overall look. Add a quirky touch to your wall decor with this beautiful frame! |
Q:
Change default file name for Windows Snipping Tool
I am looking to change the default file name for snips created by the Windows Snipping Tool. See below for a screenshot of the Save window:
I would like to be able to change the default file name from Capture.PNG to something else, like Capture-Timestamp.PNG where Timestamp is the current date and time.
How do I do this?
A:
Changing the default filename is not supported with the Snipping Tool. Consider using a third-party utility, such as ShareX or Greenshot.
|
LUCKNOW: Samajwadi Party president Akhilesh Yadav on Monday targeted the Yogi Adityanath government over allegedly spraying a group of migrants returning to their homes in Uttar Pradesh with "chemicals" to sanitise them.According to the report, the incident took place in Bareilly and several migrants including women and children complained of burning sensation in their eyes."The spraying of chemicals on migrants to sanitise them has raised some questions. Has the World Health Organisation given any direction in this regard? How do you treat the burning sensation caused by the chemicals? What arrangements are there for people to change out of wet clothes? What alternatives are being provided for the food that gets wet due to the spraying?," Yadav tweeted.The former Uttar Pradesh chief minister also tagged a news report along with the tweet which showed a group of people sitting on the road being sprayed with a liquid which the article claimed was a chemical. PTI ABN |
Predicting protein sub-Golgi locations by combining functional domain enrichment scores with pseudo-amino acid compositions.
Golgi apparatus is an important subcellular organelle that participates the secretion pathway. The role of Golgi apparatus in cellular process is related with Golgi-resident proteins. Knowing the sub-Golgi locations of Golgi-resident proteins is helpful in understanding their molecular functions. In this work, we proposed a computational method to predict the sub-Golgi locations for the Golgi-resident proteins. We take three sub-Golgi locations into consideration: the cis-Golgi network (CGN), the Golgi stack and the trans-Golgi network (TGN). By combining Pseudo-Amino Acid Compositions (Type-II PseAAC) and the Functional Domain Enrichment Score (FunDES), our method not only achieved better performances than existing methods, but also capable of recognizing proteins of the Golgi stack location, which is never considered in other state-of-the-art works. |
Modern gas turbine engines operate at high rotational speeds and high temperatures for increased performance and efficiency. Thus, the materials from which gas turbine engine components are made of must be able to withstand this severe operating environment.
Most high temperature gas turbine engine components are made of nickel base superalloys which are alloys specifically developed for high temperature and high mechanical stress applications. Superalloys are often cast into the component shape. For example, directional solidification is known in the art. This casting technique aligns grain boundaries parallel to the stress axis. This alignment enhances elevated temperature strength. Directional solidification aligns the grains to minimize failure initiation sites because high temperature failure usually occurs at the boundaries between metal crystals.
An extension of the above technique is single crystal casting. Casting of alloys in single crystal form eliminates internal crystal boundaries in the finished component. Single crystal turbine blades and vanes possess superior characteristics such as strength, ductility, and crack resistance at high operation temperatures. Thus, single crystal engine components are extensively used in the turbine section of gas turbine engines. Although single crystal engine components are desirable, they are extremely costly to manufacture and defects often occur during initial manufacturing.
The successful use of conventional containerless laser deposition methods is particularly difficult for producing single crystal components of complex geometry because of inadvertent grain boundary introduction. Most prior art fabrication processes have, to our knowledge, employed finely focused laser beams of high power density to interact with the metal substrate. The result has been cracking due to at least two phenomena. The first phenomena relates to a high rate of solidification. The high rate of solidification results from the high temperature difference between the laser beam created molten pool and the substrate. This temperature difference is a consequence of the rapid heating rate which does not permit the unmelted substrate to achieve any significantly elevated temperature. This means that when the laser beam moves on or is shut off, the melted surface portion will rapidly solidify because the substrate acts as an extremely effective heat sink.
More specifically, the high power densities and short exposure times lead to high thermal gradients and high cooling rates which result in rapid solidification rates. This type of localized melting and solidification can induce thermal stresses during solidification which can lead to cracking.
The second phenomena which leads to cracking and which results from prior art teachings is that the pool is deep and has a high aspect ratio (depth to width). In the solidification of such a relatively narrow deep molten pool, several adverse effects occur. For example the heat flow will be sideways from the pool as well as down into the substrate because of the relatively high ratio of depth to width. As the solidification reaches a conclusion, there will be a high state of stress resulting from the constraint of the pool walls. The net effect of a high ratio is the introduction of high angle grain boundaries and a heavily constrained solidification condition. Introduction of high angle grain boundaries reduces the integrity of the material and increases the susceptibility to cracking. The high constraints of this type of solidification leads to high stresses during and after solidification which can also lead to cracking. Thus, for the previously enumerated reasons, prior art laser metal treatment techniques have been prone to cracking and have generally been difficult to use.
There have been attempts to alleviate some of these problems. These attempts include preheating the substrate to reduce cracking as well as the use of different filler materials, such as filler materials having more ductility and less of a propensity for solidification cracking. Unfortunately, these attempts to solve the problem have been relatively unsuccessful.
Accordingly, there exists a need for a containerless method of producing a crack free metallic article, particularly a single crystal gas turbine engine component. |
Accessing Bioactive Natural Products from the Human Microbiome.
Natural products have long played a pivotal role in the development of therapeutics for a variety of diseases. Traditionally, soil and marine environments have provided a rich reservoir from which diverse chemical scaffolds could be discovered. Recently, the human microbiome has been recognized as a promising niche from which secondary metabolites with therapeutic potential have begun to be isolated. In this Review, we address how the expansive history of identifying bacterial natural products in other environments is informing the approaches being brought to bear on the study of the human microbiota. We also touch on how these tools can lead to insights about microbe-microbe and host-microbe interactions and help generate biological hypotheses that may lead to developments of new therapeutic modalities. |
BODYBALANCE
BODYBALANCE™ is the Yoga, Tai Chi, Pilates workout that builds flexibility and strength and leaves you feeling centered and calm. Controlled breathing, concentration and a carefully structured series of stretches, moves and poses to music create a holistic workout that brings the body into a state of harmony and balance. Like all the LES MILLS™ programs, a new BODYBALANCE™ class is released every three months with new music and choreography. |
Computer Science > Information Theory
Title:Group testing schemes from codes and designs
Abstract: In group testing, simple binary-output tests are designed to identify a small
number $t$ of defective items that are present in a large population of $N$
items. Each test takes as input a group of items and produces a binary output
indicating whether the group is free of the defective items or contains one or
more of them. In this paper we study a relaxation of the combinatorial group
testing problem. A matrix is called $(t,ε)$-disjunct if it gives rise to
a nonadaptive group testing scheme with the property of identifying a uniformly
random $t$-set of defective subjects out of a population of size $N$ with false
positive probability of an item at most $ε$. We establish a new
connection between $(t,ε)$-disjunct matrices and error correcting codes
based on the dual distance of the codes and derive estimates of the parameters
of codes that give rise to such schemes. Our methods rely on the moments of the
distance distribution of codes and inequalities for moments of sums of
independent random variables. We also provide a new connection between group
testing schemes and combinatorial designs. |
When 💩 hits the fan what do you do?
As adults we all go through LIFE obstacles. These obstacles may come in many forms. Obstacles such as, financial loss i.e. identity theft, job loss or job dissatisfaction, health problems, car repairs, home repairs, relationship issues, family issues, mental health issues etc. But how do you deal with this? Do you walk around angry? Or do you find a solution? What’s your mindset? How do you deal with life when things aren’t going your way?
Attitude
How do you approach life when things aren’t going your way? Your attitude is everything. One thing I learned over time is your attitude is like a magnet. Like attracts like. Stay positive. Though we all have days where being an adult SUCKS. I mean it can get horrible. Put on your hard hat and deal with life. The waves of life can take you on a real rollercoaster. Enjoy the ride. Your problems never really disappear they take on another form, if you run away from them. Focus on the outcome that you want. Though it may be hard to stare your problems in the face, it’s the only way you learn. Life is the greatest teacher if you pay attention. Life will give you clues before success or destruction. Pay attention, but don’t hide. Once again enjoy the ride. Your ride is what makes you unique. The toughest thing to do is to cherish the bad times because it hurts SOOOO MUCH! But we have to remember the balance and how life works. There is no hot without cold, no up without down, and no good without bad. It’s all the same.
What’s life without a little adventure or adversity?
Adversity builds character and makes you stronger.
Let’s use weights as an analogy. If you don’t lift you will not get stronger. If you don’t go through adversity you’ll never learn how to overcome. Everything is designed to help you become the person you want to be. You have to be willing to fight for what you want. The characteristics that you are building now are tools for the future you. Don’t fight it. Embody your experience. Make or find the solution. You will build strong characteristics and skills. Keep this in the back of your mind when you go through adverse situations.
Think & Reflect
Is your attitude helping you find a solution? If not what are you doing to change your attitude?
Steps to help
Keep a positive attitude
Find a positive outcome and focus on that solution.
Solitude= Solution (Listen to yourself)
Face your obstacles
Remember adverse situations are tools to use for a later experience.
Stay present and learn about yourself
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Anna Karenina (R)
Tolstoy's family epic has been smartly contoured to fit just more than two hours of screen time by Sir Tom Stoppard, responsible for "literate" movies like Shakespeare in Love, as well as the screenplay to R.W. Fassbinder's clumsy adaptation of Vladimir Nabokov's Despair, a film that proves the difficulty of moving great art from page to screen. As Nabokov says, "A tinge of poshlost"-- the Russian phrase translates roughly as "kitsch"-- "is often given by the cinema to the novel it distorts and coarsens in its crooked glass." As always, wife and young mother, Anna (Keira Knightley) falls madly for a Russian officer, Vronsky (powder puffed Aaron Taylor-Johnson). The first of this match’s tragic consequences is Vronsky’s jilting of Princess Kitty (Alicia Vikander) who, in the B story, is courted by the surly, shy, and awkward Levin (Domhnall Gleeson). Levin is the bosom friend of Anna's philandering brother, Oblonsky (Matthew Macfadyen)—prey to the same governing passions as his sister and to none of the social and legal reproach. The most immediately striking element is the self-conscious theatricality of director Joe Wright's staging. Dutiful to the text, the film begins in Oblonsky's study—but this study is located in the proscenium arch of an empty theater, while an invisible orchestra is heard to tune. Wright misses few opportunities to emphasize the artifice, all in service of a commonplace argument: that life among the aristocratic class of the 19th century was entirely a matter of stagecraft. Thankfully, the men and women populating Wright's little theater are something more than cutouts. Knightley's emotions come through with a gasping immediacy, and Jude Law deserves special notice as Anna's cuckolded husband. |
Traditional Cruise
Description
With your heavily armed guide, you'll board a green craft and experience largely static creatures from the backwoods of the sun. On the way, you'll see:
Ancient Cambodian souvenirs
Roving elephant
Huck Finn falls
The twin brother of water
Lost spy
Native photo
Python vs. water beautician
Each Traditional Cruise boat has its own name. For example:
Audiovisual Queen
Treasured Woman
Suwannee Game
Zambezi Coach
Touring Tips
If it's your honeymoon, cast members may sing to you.
Policies and Warnings
No food or nudity permitted.
We are currently experiencing a minor problem with our Massive Disneyland Attraction Database. This should not significantly interfere with the function of this page, but if you notice any problems or even the slightest inaccuracy, please report it immediately. Thank you for your courtesy. |
An optical waveguide which tapers toward the end thereof is widely known. Such an optical waveguide is widely used when producing near-field light. Utilization of such near-field light is sought after at the time of writing magnetic information. When a recording layer is heated by near-field light, the coercivity of the recording layer decreases. By writing magnetic information into the recording layer with the coercivity thus decreased, it is possible to increase resistance to magnetization within the recording layer against so-called heat fluctuations. |
My words this week come from a book that I am almost finished reading. The book is set in The Philippines, the homeland of its author and is rich in local tradition and dialogue, there have therefore been many words which are new to me. However in almost all instances, Geraldine has cleverly managed to weave the definition of each Filipino word directly into the book’s narrative, meaning that I did not need to spend time researching words before being able to move on, thus enriching my enjoyment of the story.
There are just a couple of words that didn’t come complete with a definition and which I needed to research, before being able to get them into context with the storyline.
…
LECHON
Guests flocked to the buffet table filled with sumptuous dishes while one maid cut the skin of the famous lechon
LECHON – is a pork dish in several regions of the world, most specifically Spain and its former colonial possessions throughout the world. The word lechón originated from the Spanish term leche (milk); thus lechón refers to a suckling pig that is roasted. Lechón is a popular food in the Philippines, Cuba, Puerto Rico, the Dominican Republic, other Spanish-speaking nations in Latin America, and Spain. The dish features a whole roasted pig cooked over charcoal. Additionally, it is a national dish of the Philippines, and Puerto Rico. Nowadays in most of Latin America, the original use of a suckling pig has given way to a medium-sized adult pig.
…
TAGALOG
She grabbed her wallet and pulled out her New York ID. He examined it closely, then spoke a few Tagalog words into his two-way radio.
TAGALOG – A member of a people native to the Philippines and inhabiting Manila and its adjacent provinces. The Austronesian language of the Tagalog on which Filipino is based.
…
UBE
The maid popped in and announced that the yam was ready for dessert. “You have to try this ube made from scratch”
UBE – Purple Yam
Ube is purple yam, which should not be confused with purple potatoes or with purple sweet potatoes. Purple yam is not uniquely found in the Philippines but Filipinos by far use it more than anyone else to flavor and color their sweet treats and breads.
…
That’s me done for this week, what great new words have you all discovered?
Yvonne
I can’t remember a time, even as a child, when I haven’t been passionate about books and reading.
I began blogging, when I realised just how many other people out there shared my passion for the written word and I have been continually amazed at the wealth of books that are available and the amount of great new friends I have made, from literally 'The Four Corners Of The World'.
This book has been so full of new words for me, that had the author not explained most of them in the book’s narrative, I would have been constantly on the dictionary site, checking them all out. I love finding out new words and even more so, when they originate from a different culture and way of life.
I was a little nauseated by the explanation of Lechon on Wikipedia http://en.wikipedia.org/wiki/Lechon and by the many images I came across on Google. The equivalent of such a dish over here in the UK, would be a ‘Hog Roast, which is an identical prodcedure and one which I would never eat. Don’t get me wrong, I am by no means a vegetarian, but some things I do draw the line at!
Thanks for hosting and for stopping by each contributor’s blog, it is much appreciated.
The book sounds good and it’s nice that the author weaves the meanings into the narrative. Being Puerto Rican, I know and love lechon. Its a tradition to roast one during the holidays. Christmas and Thanksgiving are not complete without it. In Puerto Rico during Christmastime they roast lechon outdoors and have lots of food, friends and family over for Christmas caroling. Its very lively! Nice words this week. I’ve never heard of ube before.
I did wonder if you would know some of these words and I have to admit that ‘hog roasts’ are becoming more and more popular over here, for wedding breakfasts, outdoor shows and fetes etc. However, I can never envisage it replacing our traditional English Roast dinner as a Christmas meal, even if it were ever warm enough to eat outside over the festive season!
I had always assumed that a Yam was the same thing as a Sweet Potato, but when I had to look it up to find out what UBE was, I realised that there is a world of difference between the two and obviously neither of them are native to UK shores, although Sweet Potato is available in many UK stores now. I must admit I was more than a little surprised when I saw the colour of a UBE dessert, until I discovered that a Yam does indeed come in a purple/blue variety, which colours all the food when it is used to cook with. I think that desserts in this pretty colour would be great as a novelty for a while, but I am not sure that it is a look I could live with permanently.
Thanks for your interesting comments on this post, it is always great to learn about other people’s traditions and customs.
I had a feeling, that living in Australia, you would know at least a couple of my words this week.
Lechon seems very popular in the Philippines and from what Naida (a fellow blogger) had to say, in parts of South America as well. As I said earlier, we do have a ‘hog roast’, here in the UK and their popularity is increasing by the week, however I have never been able to bring myself to try one. I prefer my meat to be anonymous, without any appendages and in much smaller pieces!
I was totally intrigued by the ube desserts, although I am sure that if I were to go to London and search out the Philippino population, I would probably be able to buy purple yam paste somewhere. My picture is a little small to do justice to the stunning colour of the dessert, however this link shows just how attractive it all looks. |
Unusual "double density" colloid cysts.
Third ventricular tumors vary in etiology. Treatment and surgical approach usually depends on preoperative diagnosis. Colloid cysts are the most common tumors of the third ventricle and the occurrence of two colloid cysts in the ventricular system is rare. Here we present a patient with paired colloid cysts of the third and lateral ventricles that had different radiographic characteristics, and both of which were resected through a purely endoscopic approach. This is the third reported patient with dual or paired colloid cysts. It is the second report of a lateral and third ventricular cyst, and to our knowledge the first to be successfully managed with purely endoscopic techniques obviating the need for a craniotomy. This report illustrates the importance of a wide differential when investigating intraventricular lesions and provides another example of a purely endoscopic transcortical approach for the resection of colloid cyst. |
Giants reliever Chad Gaudin is charged with one count of open and gross lewdness, after an incident at a Las Vegas emergency room way back in January. It's a bizarre story that has somehow been kept quiet for six months. |
Diligent. Dedicated. Prepared.
Joshua M. Marks
JoshuaM.Marks
A trusted advisor in the real estate and business law arenas, Joshua M. Marks provides legal counsel in commercial real estate and business ventures to entrepreneurs, companies, developers and investment firms throughout Pennsylvania and New Jersey. Known best for his responsiveness, hands-on approach and ability to close transactions seamlessly, Josh has quickly risen to become one of the Delaware Valley’s most sought out real estate and business law attorneys. Josh has also negotiated employment and marketing contracts for NFL players, structured the sale of an industry-leading online company to a Canadian venture capital firm and has counseled numerous investors, professionals, business owners and entrepreneurs in the purchase, sale, lease and refinance of hotels, strip-centers, apartment buildings, medical and dental practices, and restaurant and retail establishments.
The use of the Internet or this form for communication with the firm or any individual member of the firm does not establish an attorney-client relationship. Confidential or time-sensitive information should not be sent through this form. |
Q:
Do you use linked lists, doubly linked lists and so on, in business programming?
Are data structures like linked lists something that are purely academic for real programming or do you really use them? Are they things that are covered by generics so that you don't need to build them (assuming your language has generics)? I'm not debating the importance of understanding what they are, just the usage of them outside of academia. I ask from a front end web, backend database perspective. I'm sure someone somewhere builds these. I'm asking from my context.
Thank you.
EDIT: Are Generics so that you don't have to build linked lists and the like?
A:
It will depend on the language and frameworks you're using. Most modern languages and frameworks won't make you reinvent these wheels. Instead, they'll provide things like List<T> or HashTable.
EDIT:
We probably use linked lists all the time, but don't realize it. We don't have to write implementations of linked lists on our own, because the frameworks we use have already written them for us.
You may also be getting confused about "generics". You may be referring to generic list classes like List<T>. This is just the same as the non-generic class List, but where the element is always of type T. It is probably implemented as a linked list, but we don't have to care about that.
We also don't have to worry about allocation of physical memory, or how interrupts work, or how to create a file system. We have operating systems to do that for us. But we may be taught that information in school just the same.
A:
Certainly. Many "List" implementations in modern languages are actually linked lists, sometimes in combination with arrays or hash tables for direct access (by index as opposed to iteration).
Linked lists (especially doubly linked lists) are very commonly used in "real-world" data structures.
I would dare to say every common language has a pre-built implementation of linked list, either as a language primitive, native template library (e.g. C++), native library (e.g. Java) or some 3rd party implementation (probably open-source).
That being said, several times in the past I wrote a linked list implementation from scratch myself when creating infrastructure code for complex data structures. Sometimes it's a good idea to have full control over the implementation, and sometimes you need to add a "twist" to the classic implementation for it to satisfy your specific requirement. There's no right or wrong when it comes to whether to code your own implementation, as long as you understand the alternatives and trade-offs. In most cases, and certainly in very modern languages like C# I would avoid it.
Another point is when you should use lists versus array/vectors or hash tables. From your question I understand you are aware of the trade-offs here so I won't go too much into it, but basically, if your main usage is traversing lists by-order, and the list size may vary significantly, a list may be a viable option. Another consideration is the type of insertion. If a common use case is "inserting in the middle", than lists have a significant advantage over arrays/vectors. I can go on but this information is in the classic CS books :)
Clarification: My answer is language agnostic and does not relate specifically to Generics which to my understanding have a linked list implementation.
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Influence of cage design on precision of tube-trap bioassay for attractants of the onion fly,Delia antiqua.
Responses of onion flies,Delia antiqua, to known attractants were measured in the laboratory with a novel tube-trap bioassay. The relative numbers of flies caught in tube traps baited with enzymatic yeast hydrolysate, brewer's yeast, andn-dipropyl disulfide were similar to those obtained previously with cone traps in the field. Changing the shape of the bioassay cage from a cuboid to a cylinder decreased the experimental error obtained from analysis of variance, as did rotating the floor of the circular cage. This bioassay should be useful in evaluating attractants for other insects that orient along the substrate. |
Q:
Java Servlet - Redirect URL
The URLs of my website are www.example.com/?id=THEPRODUCTID#i where THEPRODUCTID is an alphanumeric string. Please note that #i is present at the end.
The problem is that Google crawlers are ignoring the #i specified on Sitemap.xml, so the results I can see on Google are www.example.com/?id=THEPRODUCTID.
As a quick solution, I want to create a servlet that redirects www.example.com/?id=THEPRODUCTID to www.example.com/?id=THEPRODUCTID#i. I am not sure how to do the mapping, or if it should be a filter, redirect, forward,... any guidance is very much appreciated.
A:
Look into url rewriting, for instance with Tuckey, and you can get rid of this whole procedure for your external urls, and keep it on the backend.
You can create rules to have your url be like www.example.com/product/THEPRODUCTID/i on the user end and get translated to www.example.com/?id=THEPRODUCTID#i in the backend.
|
Key coverage
Black Catholic Church Retains Foothold in Changing East Austin (Audio)
It is no secret that the black population of East Austin has been dwindling as the white population has increased for the past couple of decades. But some see a bright spot in that transformation. And it is apparent on Sunday mornings.
Father Basil Aguzie at the Holy Cross Catholic Church in East Austin.Photo credit: Maggie Rivas-Rodriguez
It is no secret that the black population of East Austin has been dwindling as the white population has increased for the past couple of decades. But some see a bright spot in that transformation. And it is apparent on Sunday mornings.
Quality journalism doesn't come free
Perhaps it goes without saying — but producing quality journalism isn't cheap. At a time when newsroom resources and revenue across the country are declining, The Texas Tribune remains committed to sustaining our mission: creating a more engaged and informed Texas with every story we cover, every event we convene and every newsletter we send. As a nonprofit newsroom, we rely on members to help keep our stories free and our events open to the public. Do you value our journalism? Show us with your support. |
Blunt bowel and mesenteric injury: MDCT diagnosis.
Multidetector computed tomography (MDCT) has emerged as the imaging modality of choice for evaluating the abdomen and pelvis in trauma patients. MDCT readily detects injury of the solid organs as well as direct and indirect features of bowel and/or mesenteric injury-an important advance given that unrecognized bowel and mesenteric injuries may result in high morbidity and mortality. Nonetheless, challenges persist in the interpretation of abdominal and pelvic CT images in trauma patients. Difficulty in interpretation may result from lack of familiarity with or misunderstanding of CT features of bowel and/or mesenteric injury. Moreover, due to major technical advances afforded by MDCT, new CT features of bowel and/or mesenteric injuries have been recognized. Beading and termination of mesenteric vessels indicating surgically important mesenteric injury is an example of one of these new features. MDCT also allows for the detection of small or trace amounts of isolated intraperitoneal fluid in trauma patients, although the clinical management of these patients is still controversial. This pictorial essay illustrates the spectrum of typical, atypical, and newly reported MDCT features of bowel and mesenteric injuries due to blunt trauma. The features that help to differentiate these injuries from pitfalls are emphasized in these proven cases. |
Pal family
The Pal family (; also spelt Pala) are a Bengali aristocratic family who had formerly held lands in what is now Sylhet, Bangladesh.
History
Among the most ancient clans in their region, the Pals traced their descent from a branch of the imperial Pala dynasty of Bengal. Their line became established in Sylhet when one Kalidas Pal acquired land in Panchakhanda (in what is now Beanibazar sub-district), with the estate becoming hereditary among his descendants. Initially, the Pals ruled their territory as feudal monarchs, styling themselves with the royal title Raja. However, during the reign of Ramjivan Pal, they lost this independence, coming under the suzerainty of the Muslim rulers of Bengal.
In spite of this reduction in status, the family enjoyed considerable renown and success as private landowners. Under Pal governance, their territory (previously scarcely inhabited) was significantly developed and cultivated, allowing the migration of groups such as the Mahimals into the area. Successive members of the family became notable for their construction of Dighi (reservoirs) as well as their religious contributions, both through support of Brahmans as well as construction. One younger son, Pratap Chandra Pal, converted to Islam under the name "Prachanda Khan" and established his own separate territory, with his heirs becoming prominent landowners themselves. The general preeminence of the Pal line is displayed in a proverb recorded by the historian Achyut Charan Choudhury:
Translated, this means "Pal, Prachanda, Jangdar. These are the three mirashdars." Thus, making reference to the Pals, the descendants of Prachanda Khan and the unrelated Jangdar clan, the proverb states that there were no other mirashdars beyond these families in the region.
The influence of the Pals continued into the British era, with Munshi Hari Krishna Pal serving as Dewan to the District Collector of Sylhet. Krishnatay Dewanji, his younger brother, had the title Rai Bahadur awarded to him by the ruling government. The latter's son, Krishna Kishore Pal Chowdhury, founded the Bihani Bazar (Morning Market), from which the town of Beanibazar (now expanded into the sub-district) derives its name.
Notes
References
Category:History of Bengal
Category:Asian noble families
Category:Bengali families
Category:Bangladeshi society
Category:Bangladeshi families
Category:Sylhet District
Category:Indian families
Category:Hindu families |
Induction heating assemblies employ electromagnetic induction to generate heat. Specifically, induction heating assemblies include a conductor and an induction heating wire extending along (in close proximity to) the conductor. When an alternating electric current is passed through the conductor, an alternating magnetic field is established, which heats the induction heating wire by way of eddy currents and magnetic hysteresis.
Thus, induction heating assemblies are used in various applications that require heating, such as curing of composite structures (e.g., carbon-fiber-reinforced composites comprising thermoset resins) and heating of parts (e.g., preheating parts to be welded). For example, an induction heating assembly can be connected to (e.g., incorporated into or layered over) an insulating substrate (e.g., silicone rubber) to form an induction heating blanket. When the magnetic characteristics of the induction heating assembly at various temperatures are known, the alternating electric current supplied to the induction heating assembly may be controlled such that the associated induction heating blanket supplies the desired amount of heat.
Recently, induction heating assemblies have been manufactured in which the induction heating wire is spirally wrapped around the conductor (e.g., forms a helical coil around the conductor). Such a configuration advantageously positions the induction heating wire in particularly close proximity to the conductor.
However, unlike straight induction heating wires that can be precisely magnetically characterized using known equipment, such as an Epstein frame, magnetic characterization of spirally wrapped induction heating wires presents a challenge. The Epstein frame does not provide precise magnetic characterization of spirally wrapped induction heating wires. Furthermore, magnetic characterization of an induction heating wire prior to winding fails to account for the changes in magnetic properties that occur due to work hardening that is introduced by the winding process.
Accordingly, those skilled in the art continue with research and development efforts in the field of magnetic characterization. |
Wellness Programs
We live busy lives and need to learn how to slow down and breathe. Work on being present and how to manage your stress with your day-to-day activities. This includes meditation, sleep hygiene, and diet.
Yoga
Begin a daily movement or exercise practice.
Strengthen and improve an existing practice, or modify it after injury, illness, or surgery.
Just getting started with yoga and don't want to injure yourself? Sign-up for a session. |
Learn about this topic in these articles:
crystal defects
...and the impurity type. The Frenkel defect involves a single ion, which is displaced from its normal lattice point and shifts to a nearby interstice, or space, between atoms in the lattice. In the
Schottky defect, two ions of opposite sign leave the lattice. Impurity defects are foreign atoms that replace some of the atoms making up the solid or that squeeze into the interstices; they are...
vacancy in solids
...that give colour to many solids. Vacancies can be created by mechanical deformation of the crystal, rapid cooling from high temperature, or the impact of radiation on the crystal. In the so-called
Schottky defect, an atom moves from the inside of the crystal to its surface, leaving behind an isolated vacancy. In the Frenkel defect, an atom moves to a new position between other atoms of the... |
@import "../../../common/css/theme/dark";
@import "analyse.gamebook.play";
|
Antigay Discrimination Bill Endorsed by Republican National Committee
A controverisal bill aimed at undercutting the landmark Obergefell v. Hodges decison by the Supreme Court apparently now has the full support of the GOP's brain trust and piggy bank.
The Republican National Committee approved a resolution Monday that in essence endorses discrimination against people who are gay, lesbian, bisexual or transgender. The text of the resolution claims it aims to "protect the rights of believers to equal treatment by the government of The United States of America,” according to the Patriot Post.
Although that website says in endorsing the First Amendment Defense Act, "the GOP is trying to ensure every American can live at peace in a pluralistic society," the liberal-leaning ThinkProgress points out that the bill would prevent the federal government from acting against businesses and nonprofits that discriminate against same-sex couples. This would mean that government workers could refuse to perform their duties, and businesses and organizations — including those that operate with support of taxpayer money — would be free to discriminate.
The American Civil Liberties Union has called the bill “a Pandora’s Box of taxpayer-funded discrimination against same-sex couples and their children,” notes the Washington Blade.
Gregory T. Angelo, executive director of the Log Cabin Republicans, told The Advocate the report in ThinkProgress is an attempt to take the spotlight away from a positive move by the RNC earlier this month to reject a pair of resolutions, one calling on sex education classes to teach “the harmful physical aspects” of homosexuality and another urging states to pass laws that attempt to nullify marriage equality. “Clearly folks on the left are trying to diminish the bold stand against antigay bigotry the RNC took at its most recent meeting,” he said. “What happened in Cleveland was a major step forward for the GOP.”
Ellen Barrosse, RNC chair of the Conservative Steering Committee, told the conservative website The Daily Signal that neither the RNC resolution nor this bill have anything to do with discrimination but are instead “an attempt, for those of us who are people of faith, to protect religious organizations.”
The RNC resolution specifically references multiple cases in which private business owners have faced legal consequences for refusing to serve to same-sex couples, in violation of nondiscrimination laws. It also mentions several individuals who faced public scrutiny for their antigay views, suggesting that all of these people are victims of “intensifying hatred and intolerance.”
ThinkProgress wrote that “by allying with these individuals and resolving that their actions need to be ‘protected’ by ‘equal treatment by the government,’ the RNC has directly endorsed discrimination against the LGBT community.” |
Falling into prints
So the new month officially signifies fall. And I love me a deep purple for fall. In my mind, this colour is right up there with black in terms of versatility. And even though it’s sometimes trendy ad sometimes not, I think it really is a colour to have in your wardrobe all the time anyway. I decided to pair this deep purple-ish shirt with a pair of African print trousers that i intend to wear out this fall. I know most people will feel tempted to put away their bold prints once the colder weather sets in, but you all know that this is not the case around here. I think trousers are probably the best way to rock prints in the colder months, because you can build layers both over and underneath to keep you warm. And in the right colours and prints, you can create some great looks for all occasions. I know I’m going to be wearing this and many other pairs of African print trousers this fall and I hope you will too |
Anti-frackers demand a proposed energy research centre near Chester concentrates on renewables but avoids investigations perceived as supporting the shale gas industry.
Government-funded plans envisage a site at Ince Marshes looking at shale gas as well as carbon capture and storage with a sister site in Glasgow focused on geothermal energy.
But Frack Free Dee want British Geological Survey (BGS), who will deliver the project, to drop the shale gas research element fearing its data will be used to support the fracking industry.
Hydraulic fracturing or fracking is the controversial method used to extract the gas from the shale layer with associated concerns around water and air contamination as well as earthquakes. And the government has made no secret of its intention to convince the public that fracking can be safe using independent research.
In a statement, Frack Free Dee said: “We do not support publicly-funded research into an already failed and discredited industry and call on the British Geological Survey to remove this aspect of their research programme at Ince Marshes. There are significant issues with BGS being seen to promote this industry, including loss of professional reputation as identified in their own strategy.
“Frack Free Dee would be supportive of those aspects of research which would remove our dependence upon fossil fuels, have a positive effect on our communities, and help our nation meet its climate change responsibilities.” |
Welcome to the Reach Out to Horses® program. Our clinics & workshops are designed to give you the unique opportunity to learn the methodologies and concepts necessary to fully understand and work in the language of the horse. Created by International Equine Specialist, Natural Horsemanship Clinician, Animal Communicator and Energy Healer, Anna Twinney, this hands-on approach will allow you to gain insight and understanding into the mind of the horse, learn how to leave the one way conversation behind, and build a true connection and trust-based partnership with your horse.
The Reach Out methodologies take horsemanship to an entirely new level, incorporating body language, energy work, animal communication and other healing modalities; all of which will show you how to reconnect to your horse and yourself in ways you never even imagined. This is your chance to work with a talented, supportive and enlightened team, led by Anna herself, committed to building and enhancing the relationship between horse and human through positive understanding and genuine communication.
Anna joins Jim Swanner on radio WKAC 1080AM, in Athens, Alabama as they talk about All About Horses. She introduces her work in horsemanship, energy, animal communication and her unique perspective
and methodologies to create that trust-based partnership you've always wanted.Listen Now
DEEPENING YOUR CONNECTION WITH ALL ANIMALS THROUGH TELEPATHIC COMMUNICATIONWhether you are a veteran Animal Communicator or just starting out, you will explore just how deep you can go with your inherent gifts as an Animal Communicator. Anna will be your guide through the Jungle of Animal Communication and show you not only how to find clarity in the connection but a depth to the session that many strive to achieve.
Listen Now
Photo by Sharon Mohan
Anna’s mission is to inspire and educate people to explore the animal’s communication system and to experience a trust based relationship that aspires to mutual healing. Showing humans how horses reflect our inner-self is one of Anna’s main goals. To become the best one can be, maintaining integrity, requires us to look inside and embrace our qualities and attributes, as well as that which causes us fear or concern.
Anna is based in Elizabeth, Colorado and is available for clinics and seminars throughout the year. Visit her schedule to find out her current whereabouts or to inquire about how to host a clinic.
Check out our stories,
articles, webinars and podcasts from around the globe, as well as new
product releases, training tips and photographs that depict special
memories with people and their animal friends. If you have
a great story you would like to share with our visitors, please
send it along to Anna via an email for
consideration on the site. Due to Anna’s extensive
travel, she now offers phone
consultations as an on-going support system for existing students.
All information shared in Workshops, Energy Healing Workshops, and in private consultations are meant to facilitate health, balance and well-being in an animal. All written materials, lectures, discussions, questions and answers, references to other modalities, products and practitioners are all ways in which information may be furnished in workshops and consultations. At no time is this information meant to be a replacement for traditional medical care, veterinary treatment or a medical diagnosis for illness or injury.
Refer to a licensed medical or veterinary practitioner
for medical care and to appropriate professionals for the service you are seeking. |
The three American men whom French authorities credit with disrupting a potential terror attack on a Paris-bound high-speed train Friday are childhood friends who had all attended California’s Freedom Christian School and often played military games together growing up.
Airman First Class Spencer Stone, Oregon National Guard member Alek Skarlatos and college student Anthony Sadler were tourists trekking through Europe on a planned three-week vacation. They will return home as decorated heroes, following a scheduled visit with French President François Hollande at Élysée Palace, after authorities say they bravely took down a man they say was armed with boxcutters and several guns.
Family members on Saturday said they were grateful that a mass tragedy was averted and that the three friends escaped with their lives.
“We believe God’s providential will worked its way out,” said Mr. Sadler’s father, Anthony Sadler, a Baptist pastor. “I’m just thankful they were there and got things done.”
The three Americans had met in the Netherlands as part of their tour, which they had planned for when Airman Stone was on leave from a U.S. Air Force base in the Azores, when they boarded the train in Amsterdam, family members said. |
= OpenEMS Wrapper for ChargeTimeEU Java-OCA-OCPP
https://github.com/OpenEMS/openems/tree/develop/io.openems.wrapper.eu.chargetime.ocpp[Source Code icon:github[]] |
This invention relates to a water-injected screw compressor which comprises a compressor element with two rotors driven by a motor, which rotors are rotatable in an interior space of the compressor element, a suction conduit which connects to an inlet part, situated at the top of this interior space of the compressor element, with an inlet valve which can close off the exit giving out to this inlet part, a pressure conduit which connects to this interior space of the compressor element and in which a vessel, which at the same time is a water separator, is installed, whereby an injection conduit is installed between the vessel and the interior space of the compressor element, for the injection of water into this interior space, which injection conduit comprises a part which is situated higher than the upper side of the inlet part of the interior space of the compressor element.
With most of the oil-injected compressors, at the outlet of the compressor element or in the pressure conduit, a valve, mostly a return valve, is provided; a valve is also provided in the injection conduit.
The valve at the outlet prevents that, when the compressor element suddenly stops before the inlet valve is closed, compressed air from the vessel flows outward through the compressor element and the suction conduit.
The valve in the injection conduit prevents that, with a sudden stop, too much oil will flow through the injection conduit into the interior space of the compressor element and this latter would be filled by oil, which subsequently would prevent the starting of the compressor element, as oil is not compressible.
As the functioning of said valves, however, becomes unreliable in a watery environment, the valves at the outlet and in the injection conduit of water-injected compressors mostly are omitted and a special inlet valve is used in the suction conduit, to wit a so-called “unloader”.
This “unloader” is a controlled valve mechanism which closes off the inlet just before or immediately after switching off the compressor, such that no compressed gas from the compressor element can be blown towards outside through the suction conduit, and which prevents that, as a result of the pressure in the vessel, the compressor element should be filled with water through the injection conduit. Through this valve mechanism, after stopping, compressed gas can be blown off from the vessel.
When with such compressors, the inlet valve closes off the suction conduit before or immediately after the stop of the compressor element, the vessel and the compressor element are at the same pressure, in consideration of the fact that no return valve is present at the outlet of the compressor element.
At that moment, the water level in the vessel is situated between a minimum and a maximum, and if this water level is higher than the underside of the compressor element, then, as no valve is present in the injection conduit, water from the vessel will flow back to the compressor element, as a result of the suction effect, until the water level in the vessel is equal to the one in the compressor element.
The compressor element can become filled up with water in such a manner that starting becomes impossible.
In order to prevent this, the position of the vessel in respect to the compressor element is chosen such that the maximum water level in the vessel is situated at the height of the bottom side of the rotors in the compressor element.
This may cause problems for the construction of the compressor and has as a consequence that the compressor takes up relatively much space and therefore also the housing in which the vessel, the compressor element and the motor are installed, is relatively large. |
"I'd rather have Marcus calling the shots," Titans receiver Rishard Matthews told reporters this week. "There's proof in the success when that happens. I'd like to do no-huddle more. I know we'd all like to do it more. We definitely talk about it a lot. Sometimes we go into it a lot. Sometimes we don't. This game, we stayed in it, and I feel like we were pretty good when we're in it." |
Now that it is clear that Aaron Walker was arrested for blogging about a public figure — and that a judge has imposed unconstitutional restraints on his speech rights — the next steps are clear:
Aaron Walker needs an immediate court order modifying the current peace order. There must be a clear judicial order stating that Aaron is allowed him to blog, tweet, and otherwise express himself publicly about public figure Brett Kimberlin. Every second that he is muzzled from speaking out is an intolerable crushing of his most sacred American right of free speech.
Aaron Walker needs legal help to obtain a reversal of this unconstitutional peace order, as well as to fight the possible criminal case against him for violating that peace order.
Aaron Walker needs a permanent injunction preventing Brett Kimberlin from seeking peace orders against Aaron based on his public speech about Kimberlin.
To accomplish these goals, we need the spotlight of Big Media on this tremendous injustice. Please spread the word, far and wide.
Bingo. Coverage by the mainstream media is crucial.
Aaron Walker’s supporters are tweeting and retweeting Patterico’s transcriptions and other blog posts about this assault on free speech, but that’s not enough. These posts need to be tweeted directly to reporters, commentators, and government watchdogs: |
The present disclosure relates to a computer implemented method and system for optimizing data collection. Existing software systems which implement data collection and more specifically diagnostic data collection for problem resolution can be cumbersome, for example, due to the complexity of the data collection process. Typical data collection can also be resource intensive. The data collection process can involve dumping data and analyzing the data to isolate a particular problem/ticket. This approach can require highly skilled administrators along with end user involvement, e.g., requiring specific user to log in and out of a system, to assist with the data collection. Further, with regard to production systems, such data collection can negatively impact the performance of the system. This can negatively affect all users and/or organizations using the production system. Such delays can lead to postponement of collection, which in turn, can delay problem resolution and interfere with service level agreements (SLAs). Further, data collection for problem resolution can include a significant time commitment from resources. A significant amount of data can be collected and can be difficult to transfer and analyze in a timely fashion because of the large amount of data. For example, the data collection and the data analysis can require a significant amount of computing time and resources because of the large amount of data. |
Woman’s purse randomly catches fire during city council meeting
A city council meeting in Boulder City, Nevada was recently interrupted when a woman's purse exploded, reports KTNV.
A Facebook post from the city notes that she, "jumped out of her seat in the back of the room, and sparks and smoke were coming out of her purse."
The area fire chief Kevin Nicholson who was in attendance "helped the woman. There were flames on the front of her shirt. [He] ushered the woman outside and chambers were cleared as the smell of smoke was in the air."
The woman received treatment for minor burns before being released.
According to Nicholson, "There was a battery malfunction in her purse that ignited her purse."
See photos from the unusual incident:
3PHOTOS
Woman's purse catches fire during city council meeting
See Gallery
Woman's purse catches fire during city council meeting
A city council meeting in Boulder City, Nevada was recently interrupted when a woman’s purse exploded, reports KTNV.
A city council meeting in Boulder City, Nevada was recently interrupted when a woman’s purse exploded, reports KTNV.
A city council meeting in Boulder City, Nevada was recently interrupted when a woman’s purse exploded, reports KTNV. |
Cesium control and diagnostics in surface plasma negative ion sources.
For efficient and reliable negative ion generation it is very important to improve a cesium control and diagnostics. Laser beam attenuation and resonance fluorescence can be used for measurement of cesium distribution and cesium control. Resonant laser excitation and two-photon excitation can be used for improved cesium ionization and cesium trapping in the discharge chamber. Simple and inexpensive diode lasers can be used for cesium diagnostics and control. Cesium migration along the surface is an important mechanism of cesium escaping. It is important to develop a suppression of cesium migration and cesium accumulation on the extraction system. |
Your shoes can track allergens, pesticides and all other kinds of nasty toxins into your home. If you have children, or animals, who spend a lot of time on the floor, this is doubly worrisome.
But, if you're going to take the shoes off, you need a good way to keep them organized and out of the way. Our favorite solution might be this DIY floating shoe rack (pictured) that we nabbed from AT: Nursery. We think we could jury-rig a decent version of this with some leftover pieces of wood we have stored in the basement.
But one shoe rack won't work for everyone, so we spent some time fishing around the archives at all the AT sites. |
Leading off the top of the 1st inning, Kyle Schwarber drops a bunt down the third-base line and legs out a single |
Your Survival Guide to Avoiding High School Classmates Over Break
There comes a strange time in every Penn State student’s life, a week in the middle of spring semester when classes are canceled and we have more free time than you know what to do with. For some, this means seedy hotels in the Caribbean and frivolously taking advantage of the lowered drinking age. For others, it means a week at home with mom and dad. In a perfect world, being home would include nothing more than extravagant home-cooked meals, naps, and loads of Netflix. But unfortunately, you’ll have to leave the house at some point. This only leads to the most dreadful thing that could ever happen – running into people you sort of knew in high school.
Coming from a townie who does this daily, I can assure you that there are many different ways to dodge those geeks and freaks you used to call your classmates.
Avoid Places You Went to in High School
For starters, you should keep a three-mile radius between you and any place you used to hang out at. This includes, but is not limited to, coffee shops, restaurants, malls, gyms, parks, grocery stores, and what have you. And for the love of God, stay away from big parties. Take it from someone who spent Christmas break partying with the same nine people for a month straight. It will not end well. Besides, it won’t kill you to drive a little out of the way, especially because you’ll need any excuse not to work on that research paper you put off to do over break.
Ignore Them
If it is absolutely necessary for you to enter the danger zone, be prepared to leave your manners behind. Let’s say for example you’re at the gym (at a super obscure time because you’re smart enough not to go during the rush) and by some grace of the devil himself, the awkwardly loquacious kid from 11th grade [insert AP class here] walks through the door. Remove yourself from the situation ASAP. Stay as far away as the walls around you will allow. They say if you don’t startle them, they won’t attack. Wrap up whatever you’re doing and relocate immediately. And by relocate, I mean to a different side of town.
Avoid Eye Contact at All Costs
This is where a dark pair of sunglasses could really come in handy. Those things are like social shields, also doubling to get you into the Spring Break spirit. Close your eyes if you have to.
Make Excuses
Well, the worst has happened. You have been spotted. You are the dartboard and your classmate is the dart and they are coming in red-hot. After you get the polite small talk out of the way, you need to think of any reason to get out of there. Doctor’s appointment, a date with a guy you met on Tinder last break, mom needs groceries pronto, need to wax your eyebrows, have to change the cat litter… The more absurd, the more apparent (hopefully) it will be that you want to end the awkward conversation happening between you. You must be persistent.
Try New Things
One good thing that could come from hiding, however, is visiting new places in or around your town that you never even knew existed. You could probably still bet on running into someone you know, but at least you got some new experiences from it. Try a new pizza place or take a new route through town. Even just taking a walk instead of driving would suffice.
Stay Home
Really, honestly… Staying home for the entire break is the only fool-proof way to completely avoid everyone from your high school. Eat some snacks, get drunk with your family, and watch a ton of Netflix. Sure, you could be in Cancun, but what’s better than a constant food baby and not having to deal with ANGEL for a whole week?
Penn State’s Interfraternity Council wants to make a statement State Patty’s Day, claiming that none of its chapters registered for a social during Happy Valley’s unofficial drinking holiday this weekend. “We commend the maturity and leadership that they displayed with their collective decision,” IFC released on the absence of socials State Patty’s Day. “We fully […] |
function sortByCopyCount (snippets, type) {
return snippets.sort((a, b) => {
return type === 'copyCountAsc' ? a.copy - b.copy : b.copy - a.copy
})
}
module.exports = sortByCopyCount
|
package com.cognifide.gradle.aem.instance.tasks
import com.cognifide.gradle.aem.AemDefaultTask
import com.cognifide.gradle.aem.AemException
import com.cognifide.gradle.aem.common.instance.InstanceException
import com.cognifide.gradle.common.utils.Formats
import java.io.File
import org.gradle.api.tasks.Internal
import org.gradle.api.tasks.TaskAction
open class InstanceBackup : AemDefaultTask() {
private val manager get() = aem.localInstanceManager.backup
/**
* Determines what need to be done (backup zipped and uploaded or something else).
*/
@Internal
var mode: Mode = Mode.of(aem.prop.string("instance.backup.mode")
?: Mode.ZIP_AND_UPLOAD.name)
@TaskAction
fun backup() {
when (mode) {
Mode.ZIP_ONLY -> zip()
Mode.ZIP_AND_UPLOAD -> {
val zip = zip()
upload(zip, false)
}
Mode.UPLOAD_ONLY -> {
val zip = manager.local ?: throw InstanceException("No instance backup to upload!")
upload(zip, true)
}
}
}
private fun zip(): File {
val file = manager.create(aem.localInstances)
common.notifier.lifecycle("Instance(s) backed up", "File: ${file.name}, Size: ${Formats.fileSize(file)}")
return file
}
private fun upload(file: File, verbose: Boolean) {
val uploaded = manager.upload(file, verbose)
if (uploaded) {
common.notifier.lifecycle("Instance backup uploaded", "File: ${file.name}")
}
}
init {
description = "Turns off local instance(s), archives to ZIP file, then turns on again."
}
enum class Mode {
ZIP_ONLY,
ZIP_AND_UPLOAD,
UPLOAD_ONLY;
companion object {
fun of(name: String) = values().find { it.name.equals(name, true) }
?: throw AemException("Unsupported instance backup mode: $name")
}
}
companion object {
const val NAME = "instanceBackup"
}
}
|
---
apiVersion: snapshot.storage.k8s.io/v1alpha1
kind: VolumeSnapshot
metadata:
name: uploads-snapshot
namespace: human-connection
spec:
source:
name: uploads-claim
kind: PersistentVolumeClaim
|
Molecular cytogenetic analysis of heterochromatin in the chromosomes of tilapia, Oreochromis niloticus (Teleostei: Cichlidae).
The structure of the heterochromatic bands in mitotic chromosomes of the important tropical aquaculture species of tilapia, Oreochromis niloticus, was investigated by the combination of the C-banding technique, chromosomal digestion with two restriction endonucleases and fluorescence in situ hybridization (FISH) of two satellite DNAs (SATA and SATB). The tilapia chromosomes presented heterochromatic bands in the centromeres and in the short arms of almost all chromosomes that were differentially digested by the restriction endonucleases HaeIII and EcoRI. FISH of SATA showed that this satellite sequence is distributed in the centromeric region of all chromosomes of tilapia. FISH also revealed an intense hybridization signal for SATB in only one chromosome pair, but less intense signals were also present in several other pairs. The digestion of tilapia chromosomes by HaeIII and EcoRI was positively correlated with the position of SATA and SATB in chromosomes as revealed by FISH. The results obtained may be useful in future molecular and genetic studies of tilapias. |
Q:
How to use AudioRecorder in Android
Im creating an application in which I want to integrate the audio recording feature and the output file must me in the .mp3 format.. Please provide me some good tutorial through from where I can learn..
Thanks in advance...
A:
This is the simple code to do this.
MediaRecorder mediarecorder = new MediaRecorder();
mediarecorder.setAudioSource(MediaRecorder.AudioSource.MIC);
mediarecorder.setOutputFormat(MediaRecorder.OutputFormat.THREE_GPP);
mediarecorder.setAudioEncoder(MediaRecorder.AudioEncoder.AMR_NB);
mediarecorder.setOutputFile("/sdcard/myv.mp3");
try {
mediarecorder.prepare();
} catch (IllegalStateException e) {
// TODO Auto-generated catch block
e.printStackTrace();
} catch (IOException e) {
// TODO Auto-generated catch block
e.printStackTrace();
}
mediarecorder.start();
|
Molecular events associated with Macrovipera lebetina obtusa and Montivipera raddei venom intoxication and condition of biomembranes.
Studies on the interaction of snake venom and organized lipid interfaces have been conducted using a variety of systems, including BLMs, SUVs and GUVs. The present study was undertaken to elucidate how the plastic properties (namely, its microviscosity, thickness, permeability) of model membranes from native lipids of different tissues of rats change in the course of Macrovipera lebetina obtusa (MLO), Montivipera raddei (MR) and Naja kaouthia (NK) venoms processing. The presence of viper venom in organism leads to increasing of the electrical resistance of BLMs from liver and muscle lipids approximately on a sequence, while the BLMs from brain lipids have not shown noticeable differences of plastic properties compared to the control. Giant unilamellar vesicles (GUVs) with a mean diameter of 30μm have a minimum curvature and mimic cell membranes in this respect. Snake venom was added to the sample chamber before the vesicles were formed. The membrane fluorescence probes, ANS and pyrene, were used to assess the state of the membrane and specifically mark the phospholipid domains. Fluorescent spectra were acquired on a Varian fluorometer instrument. ANS and pyrene allow us to quantify the fluidity changes in the membrane by measuring of the fluorescence intensity. The presence of viper venom in GUVs media reveals a noticeable decreasing of membrane fluidity compared to the control, while the binding of fluorophores with GUVs modified by venom leads to the appearance of channel activity. These studies also emphasize the importance of a membrane surface curvature for its interaction with enzymatic components of venom. |
Functional mutation analysis provides evidence for a role of REEP1 in lipid droplet biology.
Hereditary axonopathies are frequently caused by mutations in proteins that reside in the endoplasmic reticulum (ER). Which of the many ER functions are pathologically relevant, however, remains to be determined. REEP1 is an ER protein mutated in hereditary spastic paraplegia (HSP) and hereditary motor neuropathy (HMN). We found that HSP-associated missense variants at the N-terminus of REEP1 abolish ER targeting, whereas two more central variants are either rare benign SNPs or confer pathogenicity via a different mechanism. The mis-targeted variants accumulate at lipid droplets (LDs). N-terminal tagging, deletion of the N-terminus, and expression of a minor REEP1 isoform had the same effect. We also confirmed an increase in LD size upon cooverexpression of atlastins and REEP1. Neither wild-type REEP1, LD-targeted HSP variants, nor a non-LD-targeted HMN variant reproduced this effect when expressed alone. We conclude that the N-terminus of REEP1 is necessary for proper targeting to and/or retention in the ER. The protein's potential to also associate with LDs corroborates a synergistic effect with atlastins on LD size. Interestingly, LD size is also altered upon knockdown of seipin, mutations of which also cause HSP and HMN. Regulation of LDs may thus be an ER function critical for long-term axonal maintenance. |
This invention relates to an air intake manifold assembly for a v-shaped engine having two banks forming a V pattern.
For such an engine, manufacturers employ air intake manifold assemblies that comprise an upper manifold portion and two lower manifold portions. A single fuel rail or conduit is frequently used to communicate fuel from a fuel tank to the combustion chambers of both banks of the engine through fuel injectors of the fuel rail. The fuel injectors that extend from the fuel rail also take a v-shaped form to meet each cylinder. Due to the proximity of the ducts of the air intake manifolds to the ports for the fuel injectors, manufacturers mold the ports and ducts together as part of the lower portion of the manifold assembly.
The manifold assembly generally consists of a pair of lower manifold portions, a fuel rail assembly, and a single upper manifold portion. The fuel rail is installed into the lower manifold portions from above. Then, the upper intake manifold is installed on top. A set of seals and additional components hold the manifold portions together. Moreover, the interface between the lower intake manifold and the engine requires another set of seals and components to assemble the lower intake manifolds to the engine.
The present design of manifold assembly has several drawbacks. The splitting of the manifold assembly into upper and lower manifold portions requires additional componentry as well as labor and time to assemble. Each portion also requires separate tooling and capital expenditures to manufacture. Finally, handling and inventory costs are increased as a consequence of the multiple components required by the current design.
A need therefore exists for a simplified manifold design that permits easy installation and service of the fuel rail and manifold assembly for a v-bank engine.
The present invention moves the location of the fuel injector ports from the air intake manifold to a separate support. In so doing, the lower portions of the air intake manifold assembly may be combined with the upper portion to form a single unit, thereby reducing the number of manifold components. As a consequence, no additional tooling is required to form the lower portions of the air intake manifold. Only a single tool to form the single unit manifold is needed. Labor and parts costs are also reduced.
The invention comprises a manifold assembly. The air intake manifold has ducts that communicate air to the engine. A single fuel rail has fuel injectors for supplying the engine with fuel. The inventive design employs a separate support having ports to receive the fuel injectors and having seals to assist in the communication of air from the air intake manifold to the engine.
The support member has duct passages in communication with the ducts of the manifold and has fuel injector port passages in communication with the fuel injectors of the fuel rail. In contrast to the prior art, the fuel injector port passages may have a predetermined length greater than the length of the duct passages. The support member may comprise a planar member. For a v-shaped engine, two support members may be used to interface the ducts and injectors of the manifold and fuel rail with each bank of the engine.
The fuel conduit may be mounted to the air intake manifold. Seals may be used between the duct passages and the ducts. These seals may be mounted to the support member. In addition, seals may be used between the duct passage and the engine. These seals may be mounted to the support member.
The air intake manifold assembly may have a planar member acting as a support comprising duct mounts in communication with the ducts of the manifold and fuel injector port mounts in communication the fuel injectors of the fuel rail. The fuel injector port mounts may have a predetermined thickness greater than the thickness of the duct mounts. Seals may be used between the duct mount and the duct and may be mounted to the planar member. Seals may also be employed between the duct mounts and the engine and mounted to the planar member.
Hence, the fuel injector ports are located separately from the air intake manifold. The support member is then mounted to the engine with each fuel injector positioned into each fuel injector port. This design then allows the air intake manifold to be mounted as a single unit on the engine. |
Building public support for eradicating poverty in the UK
Public support is needed to ensure that the government and other organisations take action to tackle poverty in the UK. The perception of poverty is often misguided, with people believing that it is a result of laziness, or an inevitable part of modern life.
The aim of this research is to identify ways of changing such perceptions and building public support for addressing the problem. |
Q:
What is an easy definition of memory abstraction? what could be a good analogy?
What could be a good analogy of "memory abstraction" in computer architecture.
When i Google about it, I get:
A memory abstraction is an abstraction layer
between the program execution and the memory
that provides a different "view" of a memory
location depending on the execution context
in which the memory access is made.
I don't even know what abstraction is.
Please help!.
A:
An abstraction is a layer that sits between two systems and handles the communication, so neither side needs to know about how the other works directly.
I real word example may be the menu at a restaurant is an abstraction layer between the customer and the cook, I don't need to worry about telling the cook how to cook what I want, I can just pick it from the menu, and let them worry about how it comes together.
A more common abstraction in software is a service layer that a web application can send data to in order to have it stored in a database. This allows the application to just send data, and not care if it is going into a MySQL DB, A Mongo DB or whatever, the details of how it is stored are abstracted away, all the application needs to know is that it is stored.
"memory abstraction" is similar, if I have a memory abstraction layer, I can just ask it to store some data for me in memory and not worry about where it's stored, when it's cleaned up or what memory addresses it's in. The abstraction layer can handle the details like that for me.
More good information here... https://en.wikipedia.org/wiki/Abstraction_(computer_science)
|
Column As an ardent C++ developer, I’m often traumatized by the amount of potentially useful software infrastructure that simply doesn't exist.
When working in Java there are multitudes of frameworks and reusable libraries that allow many problems to be solved at high levels of abstraction without reference to the underlying technology. So why are there so many things the C++ developer must do by hand, which a Java developer can do by reusing existing code?
Is the lack of these frameworks and libraries one of the reasons why the language is losing ground to Java? In this article, I shall examine these points to see if they’re true; and attempt to determine the obstacles to greater code reuse in C++.
Before we start out, let's get a common picture of what type of code we want to reuse. We’ll start by making a distinction between two types of reusable code; a plain old library containing factorised code and the more interesting case containing tools, code-generators and support libraries that provide a means of transforming between the different domains of a data model. An example of the second is an SQL abstraction framework that takes a representation of the SQL schema and generates classes so that the relational data model can be manipulated in the object oriented domain.
In general, the problem of manipulating data in a foreign domain is tedious and time consuming. One approach to interfacing with databases is to call an interface library, perhaps ODBC or even something more proprietary. Such libraries will present everything needed to access the data in its relational form; the code to maintain integrity in the relational model [in purist terms, a proper RDBMS - relational database management system - should maintain its own integrity without relying on the programmer – ed] and the deletes and update code must be written by hand.
This hand-written code is tedious, time-consuming to write and if not carefully managed it will create dependencies on the database interface library everywhere. With an SQL abstraction framework, we use a description of the data model to generate both the SQL and all the code mentioned above.
In other words the mapping from relational to object model is now expressed in generated code, which means, firstly, that it doesn’t need to be written by hand; and, secondly, that the details of handling relational data and interfacing with a database are hidden behind an object oriented interface. Most of us will agree that generating this data model transformation is a significant saving in time compared to writing it by hand. In addition, using the generated object oriented interface means that the code using the database can focus on what it needs to do rather than the details of handling relational data and interfacing with the database.
An example of such a framework in Java is Hibernate. Similar tools for XML and other technologies are plentiful in Java. In C++ this infrastructure is harder to find; it exists but normally needs to be paid for or isn’t as dependable as the Java equivalent. So why is it that we see more of such infrastructure in Java as opposed to C++?
Is it just that Java is the obvious choice of technology for anything involving XML or databases and these frameworks don’t exist in C++ because nobody would use C++ for this type of problem? I’m not sure that this is so self-evident; the languages are not so different that something modelled in one cannot be modelled in the other with more or less the same level of difficulty.
However, just as portability is often a strong argument for using Java for a problem, there is also often a performance argument for using C++; and, for this reason, you could expect that some programmers in any problem space where Java is applied would sometimes prefer C++ solutions. |
PCNA: a silent housekeeper or a potential therapeutic target?
Proliferating cell nuclear antigen (PCNA) is known as a molecular marker for proliferation given its role in replication. Three identical molecules of PCNA form a molecular sliding clamp around the DNA double helix. This provides an essential platform on which multiple proteins are dynamically recruited and coordinately regulated. Over the past decade, new research has provided a deeper comprehension of PCNA as a coordinator of essential cellular functions for cell growth, death, and maintenance. Although the biology of PCNA in proliferation has been comprehensively reviewed, research progress in unveiling the potential of targeting PCNA for disease treatment has not been systematically discussed. Here we briefly summarize the basic structural and functional characteristics of PCNA, and then discuss new developments in its protein interactions, trimer formation, and signaling regulation that open the door to possible therapeutic targeting of PCNA. |
Here I am, once again. It's Friday, which means it's time for another blog post. Onwards!
Custom Fonts
This is the format XNA uses (and most other programs) to read .png images as fonts. I removed it, but there is always a magenta background with transparent blocks for the letters.
The typical way to draw text in XNA is to load the fonts through a custom content importer called a Spritefont. However, little did I know until recently that you can draw your own fonts and load them almost the exact same way. In the picture above, you can see how the symbols are laid out. All I really needed to do was transform an existing font into .bmp format using separate software, add my own twist to it, and then add other details like outlining and gradients. You'll see the font in action below.
Settings UI
While a very necessary user interface to have, most players will usually only open this a few times through an entire playthrough. I'll describe the settings below.
Display. This tab contains options for changing the screen resolution, fullscreen, vsync, gamma, and other options.
Audio. This tab has options for changing the master, sound effect, ambiance, and music volume.
Controls. This tab lets you change the keyboard controls of the game.
Stats. A fun tab that shows the player various statistics, like "total deaths", "maps visited", and other information. I may end up moving this to a separate "Player Info" UI.
There is still some minor stuff I need to add in, like icons to represent the different tabs.
Dialogue UI
Example: Getting an item from the Island Merchant.
A pretty generic game dialogue interface. You click a button to begin conversing, they say words, you say words... repeat. I can have the character check if the player has an item, give the player a new rumor, take money, and other similar actions. It's not quite to the level I want it just yet, but it's getting there. I'll need to add saving and better option limiting, then I can it's on the level of Skyrim's dialogue. If not in code complexity, than in perceived functionality.
Pathfinding
This took up the majority of my week, but I'm glad I have a better understanding of pathfinding. The purpose of A*(A-Star) pathfinding is for monsters and animals to find the lowest cost route from their position to the goal, and is perhaps the most popular method of pathfinding in 2D games. If you want to read more about this, here is one of the best articles I've read on the subject (complete with animations, too!). In the picture above, light gray tiles are open, dark gray tiles are walls, and red tiles have a higher cost to travel over. The red tiles can represent a swamp or river where movement is slower, and will discourage creatures from travel through them. However, if there is no other way, the creature will take the slower route.
Site Improvements
I've been slowly updating the website when I can, and have changed over from using the default Squarespace commenting system to Disqus. If you don't have an account for Disqus, it's free and the a majority of websites use it. Some other styling features like image borders.
Male character template
Lastly, I've been working on the character template for both the player classes and characters. Hopefully I'll be able to move away from those convenient but ugly gray blobs soon! It's the animation part that I'm not very good at yet.
That's the end of my past two weeks. I'm currently planning the crafting UI(s), so expect that next week.
If you have any ideas, constructive criticism, or just want to tell me how much you hate my game, you can: Send me an email, tweet @TheShyyGuy, comment on the facebook page, or respond here! |
The Hereford establishment is self-contained and deliberately keeps its distance from the rest of the Armed Forces, to the extent that it has its own fleet of helicopters as well as specially adapted Hercules transport aircraft that are kept on permanent standby at RAF Brize Norton in Oxfordshire. The regiment has its own budget, which it uses to acquire state-of-the-art surveillance and communications equipment, as well as the latest weaponry. Such is its determination to be self-sufficient that the SAS even trains its own German Shepherd tracker dogs, which are parachuted into hostile environments strapped to their trainers’ bodies. |
Integrated navigation systems ("INS") are employed within vehicles in order to provide vehicle position and velocity information with respect to a specified reference frame. A typical INS determines estimates for the position and velocity of a vehicle based on a collection of data taken from inertial sensors such as acceleration and rate sensors mounted in the vehicle, as well as sensors based outside the vehicle such as a global position system ("GPS"). Typically, the INS will use this sensor information, along with a model of vehicle motion behavior to form a set of navigation equations, in order to estimate vehicle position information and derivatives. Conventional INS may be used in "turn-by-turn navigation" systems, within "in vehicle dynamics" systems, and within proposed vehicle enhancements such as "adaptive cruise control."
A key element and/or function of the INS is the estimation of sensor errors used in the navigation equations. All sensors used by the INS have a scale factor that relates the sensor output to the sensed attribute, and a bias error (i.e., the sensor has a nonzero output even when the sensed attribute is zero). If the bias error or scale factor estimates are calculated incorrectly, the calculated vehicle position, heading and/or speed will be in error, and the reliability of the INS will be undesirably reduced. This sensor error estimation is especially important in situations where data from the GPS may become unavailable (e.g., under bridges or within tunnels).
Efforts have been made to reduce the impact of the scale factor and bias error estimation through the use of high quality inertial measurement equipment. However, the relatively high cost of such equipment is prohibitive for automotive applications. Hence, sensor error estimation is critical in conventional systems utilizing lower quality sensors.
Conventional sensor error estimation is typically performed by developing sensor error models, and then implementing the model parameter estimation as augmented equations in the overall set of navigation equations, usually in a "Kalman" filter. The Kalman filter approach has desirable stability properties, but is somewhat limited, as it provides only statistical representations of errors, and requires the implementation to be added to the overall navigation equations. Other attempts at estimating these types of sensor errors have been made using neural networks. While neural networks have the advantage of learning in the presence of noise, they often require a relatively large number of learning examples (e.g., a training set) which are needed for the training phase. The required "training" process is relatively complicated, time consuming and computationally intensive, and is therefore not suited to be carried out "on-line" or during the normal use of a vehicle.
Applicants' invention addresses these drawbacks and provides a method for accurately estimating sensor errors within an integrated navigation system such as scale factor and sensor bias errors. |
Manganese-Based Nanogels as pH Switches for Magnetic Resonance Imaging.
pH-responsive nanogels (NGs) were used to prepare high-efficiency magnetic resonance imaging dual T1/T2 contrast agents for pH imaging. The polymeric NG matrix acts as a strong polydentate ligand that chelates the Mn cations in its inner cavity generating a hybrid NG structure. The Mn chelate NG is sensitive to pH changes, such that protonation induces a change of the polymer hydration state and consequent swelling. The swollen nanogel allows water molecules to enter and interact with the Mn chelate, shortening the relaxation time (switch ON) and giving rise to positive or negative contrast on T1- or T2-weighted magnetic resonance images. |
Support
Your family and friends
Most people manage hepatitis C treatment well, but for some it can be stressful. Preparing the important things with those around you, can make being on treatment easier.
The treatment may have some side effects, so ask your doctor what side effects you may experience and how to deal with them. You may want to discuss this with your family and friends if you think you will need their support. They can also help you remember to take the medication and assist with household tasks.
For appointments with your doctor, try to take someone you trust with you. They can support you at the appointment, remind you about questions you want to ask and help you remember what the doctor said.
Peer and group support
Support groups and networks can provide valuable support during treatment, especially if you are having difficulties dealing with the side effects. Many Hepatitis organisations have support groups for people on hepatitis C treatment or people with hepatitis C.
Who should I tell?
This is a common question that is difficult to answer because everyone is different, with different relationships, different friends and different needs. When you first find out you have hepatitis C it is your choice who you want to know about it. It may be helpful to think about what you want to say and who you want to tell. Also, think about whether you trust them and whether telling them will help you in some way.
Telling health care workers, such as your dentist or other doctors, can help them give you the best medical care, but it is your choice. Health workers involved in your care have a responsibility to protect your privacy and keep your information confidential. They cannot discriminate against you in any way.
You don’t have to tell your boss or anyone you work with that you have hepatitis C unless you want to. A caring and understanding employer can make things easier for you by giving you time off if you aren’t feeling well. You are in the best position to decide who to tell and how they may react.
Talking to people about having hepatitis C can be very important to your health. Talking to people who understand will help you cope with hepatitis C, and any stress it can sometimes create.
There are some situations where you are required by law to report your hepatitis C status. These include:
If you are donating blood at the Blood Bank
If information about infections and illness is requested by some insurance companies
If you are a member of the Australian Defence Force.
Confidentiality
Confidentiality means that any information a health service has about you is private, and they cannot give that information to other people without your permission. In Australia, it is against the law for any health care professional to discuss your private information with others. This applies not only to doctors and nurses but also to social workers, counsellors, interpreters and reception staff. None of these people can tell your husband, wife, partner, parents or children about your health without your permission.
Sometimes it may feel like too many people know your private business. For example, in a clinic you may see a number of doctors, nurses and other staff. This is because in hospitals and clinics staff usually work as a team. Any information or discussion they have about your health is so they can provide you with the best possible care.
In addition, any information that you give to your boss about your health is private and confidential and they cannot pass this information to another person or organisation without your permission.
Discrimination
Discrimination means to act unfairly against a person or a group of people because of their gender, sexuality, race, colour, health problems or religious beliefs. In Australia, it is against the law for any health care professional to discriminate against you, or refuse you service for any of the following reasons:
You have hepatitis C.
You do not speak English or speak English with an accent.
You are not an Australian citizen.
You are an injecting drug user.
If you feel that you have been discriminated against or treated unfairly for these or any other reason you can make a complaint. See the Finding services section on our website for relevant phone numbers in each State and Territory. |
Ra(i)sing the towerSpeak not of resurrection, one saviourwill do. Leave out the phoenix too, the Greek hope built on smoke and ashes. Speak not of the slopeto the bottomless realm. Check your behaviour.Defenceless and featherless, he stiffly treadsthe whiteness of the theatre, losing pride;no father and no deity by his side,he is naked like the first. His body spreads.First of all this tower crumbles and implodes.The soul skims Babel, reconsiders, reckonsonce more. Homo Erectus prevails, unbowedstill, the man stands tall again, his Muse beckonshim, reincarnation is a might-have-been:re-entering yourself, you’re the man-machine.translation: Erik Honders |
Copper-catalyzed cyclization/aza-Claisen rearrangement cascade initiated by ketenimine formation: an efficient stereocontrolled synthesis of α-allyl cyclic amidines.
An efficient and convenient synthesis of α-allyl cyclic amidines has been achieved by applying a novel cascade reaction. Copper(I)-mediated in situ N-sulfonyl ketenimine formation from the reaction of a terminal alkyne with sulfonyl azide is followed by an intramolecular nucleophilic attack on the central carbon atom by an allylic tertiary amine, and then an aza-Claisen rearrangement takes place through a chair transition state to furnish the titled amidines with complete stereocontrol. |
Kristoff and Anna were obviously in love.
The way Kristoff looked at Anna was akin to a small child looking out into the Grand Canyon for the first time; in awe and maybe even a little bit afraid of the strength of their own feelings, vertigo flipping their stomach. He enjoyed constant contact with her and the press of her lips against his, but he was very respectful of her personal space and was willing to wait as long as he needed to before she was ready to… to… go all the way. Truth be told, he wasn't sure that he was quite ready for that step, although sometimes she got his dick so hard he was afraid he'd pass out. But she was just so beautiful, and he was so weak. She didn't blame him for it, and sometimes… sometimes she'd let him "take care of it" with her watching.
Anna… was a different story.
Her affections were more sly, more subtle, built in sidelong glances and innocuous brushes of skin on skin. She'd kiss chastely with the heated promise of more, let pressing, full bodied hugs linger past the length propriety would allow for, giggle and flirt with the twirling of her hair and a hand lain on a shoulder.
And Kristoff was totally oblivious that she felt this way for Elsa.
Oblivious to the fact that, while she sat wriggling in his lap after dinner, giggling as he tickled her sides, her eyes were locked with her older sister. That when she licked her lips, Elsa shuddered, crossing her arms to hide her stiffening nipples.
That they'd been fucking for far longer than she and Kristoff had even started dating.
As Eugene and Rapunzel finished up their meal, Elsa began gather the dishes to bring into the kitchen. Anna hopped off Kristoff's lap, leaving him to quickly conceal his raging boner. "Lemme help with that, sis," Anna said cheerfully, a large grin on her face. None of the others thought anything of it; Anna was a helpful person and for her sister she would do anything. But Elsa knew. Her breath hitched and her pupils dilated. She could only nod as they cleared the table, working around their friends as they spoke.
"That was a very good dinner, Els," Kristoff complimented, beaming at her. She flushed but met his gaze with a grateful smile. "Thanks for cooking."
"You're welcome, Kris," Elsa murmured, very aware of Anna's amused gaze burning into her back. Eugene let out a large burp and everyone groaned at him. He laughed.
"Sorry, sorry! You know that's a compliment in some countries," he whined, laughing again when Rapunzel slapped his chest. "Anyway, yeah, great dinner, Elsa. You know, I've been thinking…maybe next time we could invite Jack?" Elsa glanced sharply at Anna, but the amusement in her expression didn't lessen in the least. "I mean," Eugene continued, leaning forward in his chair. "Think about it. There's me and Blondie, Anna and Kristoff… and you, Elsa. I just don't want you to feel like a fifth wheel, babe," Eugene said, turning to Elsa and grinning. His smile softened. "I figure you'd be in a group, and he could find out you're a wonderful cook and maybe that'll make up for your crippling social anxiety." Rapunzel slapped him again, this time in the back of the head.
"You're such an ass, Eugene!" He shrugged his shoulders and looked apologetically at Elsa, who waved him off.
"Just because I didn't like talking to you when you first came along doesn't mean I'm totally inept, Flynn. It just means you're a tool that I barely tolerate for my cousin's sake."
Kristoff guffawed and Rapunzel giggled uncontrollably at Eugene's slack jawed expression. Anna smiled and nudged Eugene with her hip, hefting the dishes and walking towards the door to the kitchen. "She got you there, Flynn," Anna said, chortling. Elsa sent him an apologetic smile and followed her sister into the kitchen, listening as the raucous conversation continued on behind them.
Elsa closed the door after walking through, her share of the dishes propped against her hip. Anna, who had already dumped the cups and bowls into the sink, breezed past Elsa on her way there. Elsa heard the click of the lock behind her and leaned against the counter, squeezing her thighs together in anticipation.
Anna pressed against her back, hugging her from behind and brushing her lips against Elsa's ear. "Hi," she whispered, tongue snaking out to taste Elsa's neck.
Elsa turned and kissed Anna's lips softly, enjoying the feeling of their bodies held against each other. She took her time, hands sliding up and down Anna's back as the redhead wrapped her arms around Elsa's neck. They swayed in place as the kissed, smiling broadly against each other's lips. Anna hummed contently, nipping Elsa's bottom lip and giving a low groan when Elsa pushed her knee against Anna's center in retaliation. "Hi," Elsa said breathlessly, finally breaking the kiss. Anna winked and pecked her lips one more time before resting her head on Elsa's shoulder and inhaling slowly.
"I missed you," Anna cooed, pressing the pads of her fingers underneath Elsa's shirt and drawing circles on her sides. Elsa smiled, her face reddening slightly, and dipped her head to capture Anna's lips gain.
"I was sitting right there," Elsa pointed out, breath catching in her throat when Anna's hands started crawling up her torso underneath her blouse.
"I guess I just missed these, then," Anna corrected, squeezing Elsa's breasts over her bra and slipping her tongue along Elsa's clavicle.
Elsa had to bite back a laugh and lowered her voice to a growl. "Oh really? Is that all?" she asked, inserting her fingers into Anna's belt loops and pulling her hips closer. "Is that all you want from me, little sis?" Her hand rested on the button of Anna's jeans and slowly began to undo it. "Because I want a bit more than that."
Anna sucked in a breath and looked up at Elsa with wide eyes. "Seriously?" she said, tone more excited than nervous. "They're right there." Elsa smirked and rubbed her nose against Anna's before kissing her again, flicking her tongue against Anna's lips.
"Guess you'll have to be really quiet then."
Anna let go of a shuddery breath and nuzzled into Elsa's chest as she unbuttoned Anna's jeans and tugged them down a bit, just past Anna's ass. Elsa's eyebrows shot up and she could feel Anna grinning against her skin. "Surprise."
Anna was not wearing any panties. She'd been wriggling around on top of Kristoff, going commando, and he had no idea. Elsa stared at the small thatch of red hair on her sister's mound, mouth watering. It was all for her.
She wanted to taste but knew they didn't have time, knew Anna wouldn't be able to keep quiet if Elsa put her mouth on her.
Her hand slipped into Anna's jeans, over her mound and between her thighs where her slit was already wet and waiting for Elsa's fingers.
"Who did this to you?" Elsa purred, her lips brushing against Anna's ear. The redhead shivered and arched into Elsa as her older sister slipped easily inside slightly, rubbing the shallow dip in between Anna's lips."Who got you so wet, so excited?"
Anna inhaled sharply as Elsa crooked her finger inside of her, her thumb brushing against Anna's clit. "You," Anna answered breathlessly. "It was you, all you."
Elsa drove deeper into Anna's soaking cunt, nudging her chin up with her other hand and pressing a hard kiss against her lips. "Do you want me to fuck you? Finger you til you cum with your boyfriend a room away?"
"Yes," Anna groaned, humping against Elsa's hand and breathing hard against her mouth. "Oh god, Elsa,please."
"Please what?" Elsa teased, withdrawing her finger and circling Anna's clit with the lightest of pressure.
Anna's darkening eyes met Elsa's and she panted, her hands gripping Elsa's shoulders. "Finger fuck me until I'm silently screaming your name and cum so hard I can't breathe." Her voice was so deep and coarse it sent shivers down Elsa's spine, and the blonde had to look away from the intense gaze. "Pretty please?" Elsa groaned at Anna's teasing tone, and repeated the noise when she felt Anna's tongue trace her jaw line.
"You drive me absolutely insane, do you know that?" Elsa muttered, her breath hitching as Anna's tongue descended onto her neck and drew geometric designs across her oversensitive skin.
"I know," Anna replied cheerfully. Elsa drove her fingers into Anna's slick cunt spitefully, relishing the sharp gasp that escaped her sister's throat. "Fuck yeah, Elsa… You feel so good inside of me, sis, so fucking good…" Anna's whispered praise blew hot breath over Elsa's shoulder and made the older woman shiver with absolute desire as she pumped in and out of Anna.
A sound from the other room startled the two, but Elsa only moved faster, curling her fingers inside of Anna and caressing the sensitive cluster of nerves within her. Anna let out a rather loud squeak, so Elsa covered her mouth with her own, drawing Anna's tongue into a ferocious and deep kiss. "You have to be quiet," Elsa whispered, the corners of her mouth twitching up when Anna buried her face in the crook of Elsa's neck and puffed out heavy, frustrated breaths as she ground against the palm of Elsa's hand.
"I'm so fucking close, Elsa," Anna retorted, nipping at Elsa's shoulder and kissing up her neck to suck on her earlobe. Elsa's legs trembled but her hand was sure as she fucked Anna's gushing slit with two fingers, then added another and swallowed Anna's gasps in a bruising kiss as the younger woman's cunt squeezed and milked them. Elsa could feel Anna saying 'fuck' over and over again into her mouth as she bucked against Elsa, pulling her close as she wrapped her arms around the blonde's shoulders.
Elsa held her younger sister as she trembled in her arms, resting her face against Elsa's chest and trying to regulate her breathing. Elsa slipped her fingers out of Anna, prompting a whimper from the redhead, and stuck them into her own mouth, suckling loudly on them and yanking up Anna's jeans with her free hand. The tang of Anna's come almost made Elsa groan aloud, and she sucked her fingers dry, her eyes twinkling with amusement when Anna stood straight and watched her with hunger glittering in her eyes.
"Hey you guys, Punzie and Eugene were wondering- oof!" As soon as the redhead took a step forward a voice approached the door and the thud of a heavy body pushed into it. "Hey, the door's stuck again!" Anna bit her lip and pulled Elsa's fingers out of her mouth and kissed her hard, tasting herself on her sister's lips before turning and going towards the door and resting her hand on the knob.
"Hold on, this thing is old and finicky, Kris," she warned. "Step away from the door I'm gonna try and yank it open." She grunted as she turned the lock and pretended to jiggle the handle, then pulled it open with some force and almost hit herself in the face with it. "Woah!"
"Oh, jeez, babe! Are you okay?" Kristoff took Anna's face in his hands and peered at her forehead for bruises.
"I'm fine, I'm fine!" She laughed and pushed him off, kissing his cheek and causing his face to flush. His eyes flickered over to Elsa, who only seemed amused, and he yelped when Anna yanked him down and pecked him on his lips. He froze for a moment and then kissed back, licking his lips as he straightened his back.
"New chapstick, Anna? Tastes kinda funky."
The girls looked at each other and giggled. |
Q:
is "non-intrusive code-behind" a good or bad practice?
I am a bit surprised that while learning WPF/XAML/Silverlight almost all of the XAML/C# examples I have encountered have the "Click" events in the XAML and very few in the Window or Page constructor.
With all the emphasis these days on "non-intrusive Javascript", I would think that more developers would actually be structuring their XAML/code-behind like this:
XAML:
<Grid>
<Button x:Name="btnEdit"/>
</Grid>
Code behind:
public Window1()
{
InitializeComponent();
btnEdit.Content = "Edit";
btnEdit.Click += new RoutedEventHandler(btnEdit_Click);
}
private void btnEdit_Click(object sender, RoutedEventArgs e)
{
btnEdit.Content = "This button was clicked.";
}
Any thoughts on why this would be a good or bad practice?
A:
Most of the smaller WPF examples give just an impression what is possible without focusing on design issues or good style.
In real world applications XAML should only be used for declarative programming. For example, binding a command to a button or declaring a data binding. Karl Shifflett has some great articles about the MVVM pattern which separates the concerns of your WPF/Silverlight application very well.
Code behind is in my opinion just suitable for tiny applications. It tends to mix view, control and data.
|
Q:
What are the benefits to cropping dog ears?
Some pet owners crop their dog's ears. This procedure ends with the ears standing straight up. I get the impression that this is genearlly tailored towards specific breeds (stronger ones), though I don't truly know. There are various laws prohibiting these procedures in certain locations (even entire countries) because of animal cruelty. Here's a before and after photo of what I'm referring to:
I can't help but wonder if there are any upsides to it at all. Either medically, sensory, or functionally. As far as I can tell, it looks like some owners do this strictly for appearences. Upon further research, they apparently have a lot of different styles, too. Like so:
Does this provide any legitimate benefit?
Why do people do it?
A:
This is about appearance, to make them look tougher which is why it's generally done with certain breeds. Beyond that, there's no benefit to the dog, the "toughness" appearance is a human aesthetic only and many are now starting to back away from it.
Edit based on commentary... There is a possible legitimate benefit with respect reducing the risk of a yeast infection. As @RebeccaRVT notes, floppy ears can help to trap moisture in the ear canal which can lead to ear infections. Mind you, based on some of the reading I've done, this is more common in breeds with large, very floppy, ears than the ones typically cropped, but at least something to discuss with your vet.
I still think there is some additional protection for the ear canal with respect to foreign objects when left natural as well.
Now, my side editorial opinion is that I like the natural look far better. However, that's because I generally prefer the look of a happy animal rather than one that has been tailored to look mean.
|
A new code of conduct that warns patrons with "offensive odours" and those "lingering aimlessly" won't be tolerated at the Kingston, Ont., public library is coming under fire from critics who say it targets homeless people.
A group called Libraries are for Everyone says that while the new rules don't explicitly bar homeless or poor people from using the library, they will have that effect.
The group says the guidelines "may do more to stigmatize and marginalize some of the most vulnerable library patrons."
It is hoping to convince the library board to repeal the changes and launch a public consultation at its monthly meeting Wednesday night.
The library board has defended the policy, which was passed at its meeting in March but only came to the public's attention a few weeks ago.
In a statement posted on its website, the board says the guidelines are not aimed at a specific group and stresses they are required to ensure the library remains a safe space. |
Former Reddit user UncleSam4200 used to brag about being a Washington reporter and even joked that his career would be in hot water if he was ever outed, but expressed doubt that he’d ever be found out.
Now, Mediaite has revealed the former fixture on the pro-Trump subreddit r/TheDonald, is a reporter named Josh Fatzick — and is employed by Voice of America, the government’s overseas news broadcast.
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Prior to deleting his account, Fatzick was a frequent user of racist, homophobic and transphobic slurs. He would “jokingly” refer to black people as “apes” and call people he disagreed with “f*ggot” and “tr*nny.”
Using information about his college, sports preferences and former employment at the right-wing Daily Caller website, Mediaite tracked Fatzick down — and discovered that he often made his bigoted posts and comments while working his taxpayer-subsidized job.
“That’s why I have a job where I can spend most of my day making mindless Reddit comments,” he reportedly admitted.
Fatzick apparently used to enjoy criticizing liberal media figures, a harkening back to his days at the Caller.
“OF F*CKING COURSE Affirmative Action April has to start screeching like a god damn caged gorilla at the first mention of African Americans,” he wrote once, referencing veteran White House correspondent April Ryan.
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Discussing a segment in which a Fox News sports writer infamously began discussing breasts on CNN, Fatzick then took aim at host Brooke Baldwin’s body, claiming “she’s just mad cuz shes got itty bitty titties [sic]” and that she’s “f*cking r*tarded.”
Fatzick claimed to hate Asian women and regularly made derogatory comments about former First Lady Michelle Obama, and also made numerous sexist comments — in one instance, he called his girlfriend’s mother a “c*nt.” In another, he demanded a woman who posted a bikini selfie to “SHOW YOUR F*CKING TITS!”
“Voice of America has zero tolerance for public or personal racist, sexist, or politically biased social media communications. Our policies make it very clear that such behavior is prohibited. We are investigating these reports as quickly as possible and will respond accordingly,” VOA Director Amanda Bennett said in a statement. “In the meantime, the individual in question has been placed on administrative leave pending the outcome of the investigation.”
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(Note: Updated with a statement from VOA) |
They may not get as much screen time as the girls but I've never really felt the show had any anti-boy implications in it. It seems most of the fandom is where the idea comes from.
Also for thunderlane in most fan fiction he for whatever reason is usually portrayed as either an abusive boyfriend or a rapist. Meanwhile his little brother is more used as an easy to manipulate sex toy.
If anything I could more picture for his part in the picture, him with his wings spread protectively in front of rumble with a big sign behind him that says "I'd never harm a mare unless she put those I love in harms way". |
Grade Obama's NSA speech with this handy scorecard
For anyone following the seven-month-long parade of National Security Agency leaks, tomorrow is a big day. U.S. President Barack Obama is slated to unveil a series of reforms meant to address national and global concerns over the breadth of NSA spying. How much will he actually reform?
There’s quite a lot to address. After former intelligence contractor Edward Snowden handed over thousands of classified documents to the Guardian and other news outlets, the world has learned that the NSA taps Internet cables, collects social media content with secret warrants, scoops up text messages, monitors chats and emails, traces location data from cell phones, brokers deals with telecoms for user data, inserts loopholes and backdoors into encryption schemes, and keeps a database of the call logs of millions of Americans.
However you feel about NSA surveillance, it is a monumental achievement of data collection. It's so huge, and so abstracted from many of the laws that produced it, that it may be difficult to tell whether any reforms could actually address the issues at hand. To help you follow along with the president’s reforms on Friday, the Electronic Frontier Foundation has produced a “scorecard” of “common-sense fixes that the President could—and should—announce at his briefing.” As the EFF points out, the card doesn’t address every issue, but it is aimed at articulating the reforms necessary to fix the most egregious problems.
Scorecard via Electronic Frontier Foundation
The president will make his announcement at 5pm ET on Friday. You can watch it live at whitehouse.gov. |
Radiochemical studies of 99mTc complexes of modified cysteine ligands and bifunctional chelating agents.
The synthesis of four novel ligands using the amino-acid cysteine and its ethyl carboxylate derivative is described. The synthetic method involves a two-step procedure, wherein the intermediate Schiff base formed by the condensation of the amino group of the cysteine substrate and salicylaldehyde is reduced to give the target ligands. The intermediates and the final products were characterized by high resolution nuclear magnetic resonance spectroscopy. Complexation studies of the ligands with 99mTc were optimized using stannous tartrate as the reducing agent under varying reaction conditions. The complexes were characterized using standard quality control techniques such as thin layer chromatography, paper electrophoresis, and paper chromatography. Lipophilicities of the complexes were estimated by solvent extraction into chloroform. Substantial changes in net charge and lipophilicity of the 99mTc complexes were observed on substituting the carboxylic acid functionality in ligands I and II with the ethyl carboxylate groups (ligands II and IV). All the ligands formed 99mTc complexes in high yield. Whereas the complexes with ligands I and II were observed to be hydrophilic in nature and not extractable into CHCl3, ligands III and IV resulted in neutral and lipophilic 99mTc complexes. The 99mTc complex with ligand II was not stable and on storage formed a hydrophilic and nonextractable species. The biodistribution of the complexes of ligands I and II showed that they cleared predominantly through the kidneys, whereas the complexes with ligands III and IV were excreted primarily through the hepatobiliary system. No significant brain uptake was observed with the 99mTc complexes with ligands III and IV despite their favorable properties of neutrality, lipophilicity, and conversion into a hydrophilic species. These ligands offer potential for use as bifunctional chelating agents. |
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At the Deeper Well, Buffy was fighting through crowds of demons with her slayer scythe, reflecting on how she had last used it when she destroyed the Seed. Willow was also fighting with her, using her magic against the demons. Xander was back at the entrance, still texting information to Severin and Simone over their plans. Meanwhile, Severin and Simone were threatening the last guard of the Deeper Well, a little girl with a balloon. The balloon popped when Simone shot her and turned into tentacles, lunging for them. However, the battle is immediately ended when Severin overpowered and drained it of her powers. Severin ordered Xander to buy them more time to get in, only for him to be attacked by another demon.
Buffy was still fighting, this time against D'Hoffryn. During her scrap with him, Buffy was suddenly snatched up by a flying gargoyle. She struggled against it as the gargoyle nearly succeded in killing her. However, Buffy was saved when Illyria and Koh appear to decapitate it. They argued that they were with her on this, only for her to reject them. Koh admitted that he had been accused of killing his family and was consequently imprisioned for it, but had came to terms that he could not change the past, but he can still help her save her sister. She was hesitant still, but agreed that he could help, showing that she forgave his previous betrayal and could trust him.
Back in San Francisco, Billy and Anaheed are skyping with Devon, who was asking Billy to return back home and fight against the increasing zompire crowd. Dawn had freaked out and locked herself in the bathroom, unable to cope with what was happening to her. Spike comforted her from outside the door, promising her that he was there to help her. He told her stories about herself and his special bond to her, trying to make her comfortable. Dawn nervously came out of the bathroom when he got to the part about her being The Key. She lamented that she couldn't remember any of it, but what he said felt right to her. They hug.
Spike continued to tell her stories about Dawn, but he faltered when he realized that he couldn't remember everything he meant to say. Without telling her what was wrong, Spike took a tape recorder from Andrew and refreshed his memories of Dawn so he wouldn't forget her. As he was leaving another message for himself, Billy and Anaheed take off, asking Spike to tell Buffy "something about Simone Doffler" if he saw her since she wasn't answering her phone.
It cut back to the fighting in the Deeper Well. Xander was still being attacked by a demon, but was saved by Willow, Buffy, as well as Illyria and Koh. Buffy and the others talk more strategy over their next move, while Xander subtly called up Simone, again told they needed more time. Buffy and Willow are finalizing their plan and prepared to continue fighting. Xander panicked at this and told them that they'd die if they went through with it. This failed to change their resolve. Unable to watch his friends risk their lives unneccessarily, his guilt spilled over. Xander told them everything he did to turn back time and reverse Twilight with Simone and Severin.
Buffy was understandably hurt and betrayed by his lack of trust in her. Illyria then stated that what those two planned to do would create a tear in the reality, ending the world as a result. Buffy was furious, angrily saying that it wasn't just about saving Dawn anymore, now they had to save the world. Again. |
I Predict a Riot
Someone really needs to explain the whole concept of celebrating to the Big Ten.
A Bastard Illini Roommate: You know, if you like, you can go set the front yard on fire. Apparently, it's what you Carolina people do.Tar Heel March: It was a controlled fire in the midst of a joyous celebration.Another Bastard Illini Roommate: There were four of them.Tar Heel March:Four controlled fires in the midst of a joyous celebration. Harmless.Second Bastard Illini Roommate: Three people were hurt. And a bicycle.Tar Heel March: You're from a city that shoots firearms in the air after Bulls victories. Shaddup.
(In case you were keeping score, the Champaign and Chapel Hill celebrations had the same total number of arrests.) |
Chirality-Controlled Synthesis and Applications of Single-Wall Carbon Nanotubes.
Preparation of chirality-defined single-wall carbon nanotubes (SWCNTs) is the top challenge in the nanotube field. In recent years, great progress has been made toward preparing single-chirality SWCNTs through both direct controlled synthesis and postsynthesis separation approaches. Accordingly, the uses of single-chirality-dominated SWCNTs for various applications have emerged as a new front in nanotube research. In this Review, we review recent progress made in the chirality-controlled synthesis of SWCNTs, including metal-catalyst-free SWCNT cloning by vapor-phase epitaxy elongation of purified single-chirality nanotube seeds, chirality-specific growth of SWCNTs on bimetallic solid alloy catalysts, chirality-controlled synthesis of SWCNTs using bottom-up synthetic strategy from carbonaceous molecular end-cap precursors, etc. Recent major progresses in postsynthesis separation of single-chirality SWCNT species, as well as methods for chirality characterization of SWCNTs, are also highlighted. Moreover, we discuss some examples where single-chirality SWCNTs have shown clear advantages over SWCNTs with broad chirality distributions. We hope this review could inspire more research on the chirality-controlled preparation of SWCNTs and equally important inspire the use of single-chirality SWCNT samples for more fundamental studies and practical applications. |
Differential expression of Galalpha1,3Gal epitopes on fetal and adult porcine hematopoietic cells.
Galalpha1-3Gal (Gal) is the major epitope on pig tissues bound by human natural antibodies. Xenogeneic hematopoietic cell transplantation is being investigated to induce immunological tolerance to xenografts. We have investigated the level of Gal expression on pig hematopoietic cells. Cells were collected from pig fetal liver and bone marrow (BM), and also from adult BM and peripheral blood, before and after treatment with pig-specific hematopoietic growth factors. Fluorescent activated cell sorting (FACS) analysis was performed with the M86 monoclonal antibody (specific for Gal), lineage markers, and biotinylated stem cell factor (SCF) to detect c-kit expression. In fetal pig BM and liver, there was no significant difference in Gal expression between monocytes/macrophages (myeloid cells) and lymphocytes. In adult hematopoietic cells from all sources, Gal-positive subpopulations in T cells showed weak expression of Gal, whereas B cells demonstrated higher expression, and myeloid cells showed highest expression. Adult BM and mobilized peripheral blood progenitor cells contained small populations with very low or negligible expression of Gal. A very small population of c-kit-positive cells, indicating progenitor cells, were Gal-negative. The small Gal-negative population that exists in progenitor cells might explain why some pig colony forming units (CFU) can be resistant to human serum. |
Berner spends his days fishing click-streams for insights in real-time using Erlang.
Berner started his career in test automation at PacketFront, before moving on as first employee at SPAM-filtering and online security SaaS provider Stay Secure. Following this, he co-founded Campanja, taking the role of CTO. |
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*LOVE*
LOVE is a powerful thing, LOVE hurts as much as u think words do,LOVE suppose to be fun, LOVE can take you along way,away that you never dream you can go to a place where you can open your heart and just run free, LOVE makes you feel good about yourself,you wake up one morning and your heart is filled with lots of joy, LOVE make's you seem like everthing you worked for is a reason why love so special to you, LOVE is about wakeing up in the morning knowing that your days is fill with love and joy it's about haveing fun enjoying the life you have with that special someone,LOVE is away of showing respect to those who is in LOVE and those who wants to be LOVE,LOVE is happiest that bring that bring your hearts out. |
The owners of this Mt. Pleasant home wanted to upgrade the master bathroom to give it a more spa-like feel. By removing the bathtub, located in the center of the room the space immediately feels larger and more open. The new, expanded tile shower features a customizable temperature control, allowing each person the ability to program the water to reach the perfect temperature. New vanity and linen cabinets in Barnwood stain with a black glaze and Cambria countertops in "New Quay" lend warmth to the space. |
Hierarchy, determinism, and specificity in theories of development and evolution.
The concepts of hierarchical organization, genetic determinism and biological specificity (for example of species, biologically relevant macromolecules, or genes) have played a crucial role in biology as a modern experimental science since its beginnings in the nineteenth century. The idea of genetic information (specificity) and genetic determination was at the basis of molecular biology that developed in the 1940s with macromolecules, viruses and prokaryotes as major objects of research often labelled "reductionist". However, the concepts have been marginalized or rejected in some of the research that in the late 1960s began to focus additionally on the molecularization of complex biological structures and functions using systems approaches. This paper challenges the view that 'molecular reductionism' has been successfully replaced by holism and a focus on the collective behaviour of cellular entities. It argues instead that there are more fertile replacements for molecular 'reductionism', in which genomics, embryology, biochemistry, and computer science intertwine and result in research that is as exact and causally predictive as earlier molecular biology. |
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