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Saltpan Recovery Project BirdLife Partners along the East Atlantic Flyway have joined forces to save the precious saltpans of Southern Europe and Northern Africa, and the striking birds that rely on them to fuel their incredible journeys between the two continents. Millions of birds use the East Atlantic Flyway twice each year to move between their breeding and wintering grounds. On their long and hard journeys they need stopover sites to rest and feed. Greater Flamingo, Pied Avocet, Dunlin and many other migratory birds are reported to use the saltpans in great numbers. Saltpans - artificial basins built for the purpose of extracting salt from water using natural evaporation - are crucial refuelling sites for these birds. Sadly, it is a man-made habitat that is disappearing fast. Companies and cooperatives don't see saltpans as a viable business anymore and the saltpans are being abandoned as a result. In the saltpans that do remain, pollution and disturbance are becoming common problems. Our BirdLife Partners in Tunisia, Morocco, Spain, Portugal, France and the Netherlands have worked out a plan to save the saltpans and develop best practices for bird-friendly saltpan management. During the coming years we will work to remove vegetation and restore the dikes and pools that are crucial to birds and for a successful salt harvest. Engaging with local communities, cooperatives and companies to improve the business case for salt harvest will be a central aspect to our work. Furthermore, we will be raising awareness and taking action to tackle water pollution and disturbance in areas near larger cities. The project brochure below outlines some of the examples of bird-friendly managed saltpans that exist around the Mediterranean. We will tap into these examples, establish our own best practice and share them with saltpan operators along the global flyways.
Failed renoprotection by alternatively activated bone marrow macrophages is due to a proliferation-dependent phenotype switch in vivo. Alternatively activated macrophages (M2) regulate immune responses and ex vivo polarized splenic M2 are able to ameliorate renal injury including models of renal disease, such as adriamycin nephropathy. Whether M2 derived from other organs have similar protective efficacy is unknown. Here, we report adoptively transferred bone marrow M2 macrophages did not improve renal function or reduce renal injury in adriamycin nephropathy, whereas splenic M2 macrophages were protective. Bone marrow and splenic M2 macrophages showed similar regulatory phenotypes and suppressive functions in vitro. Within the inflamed kidney, suppressive phenotypes in bone marrow but not in splenic M2 macrophages, were dramatically reduced. Loss of the suppressive phenotype in bone marrow M2 was related to strong proliferation of bone marrow M2. Bone marrow M2 proliferation in vivo correlated with M-CSF expression by tubular cells in the inflamed kidney. Inhibition of M-CSF in vitro limited bone marrow M2 proliferation and prevented switch of phenotype. Proliferating cells derived from transfused bone marrow M2 were inflammatory rather than regulatory in their phenotype and function. Thus bone marrow in contrast to splenic M2 macrophages do not protect against renal structural and functional injury in murine adriamycin nephropathy. The failed renoprotection of bone marrow M2 is due to the switch of transfused M2 macrophages from a regulatory to an inflammatory phenotype.
Q: Bootstrap: error class not working with hide class I am creating a form where on error two input fields slide done and i want them to have bootstrap error class. 'error' class works fine without 'hide' class is there, but with 'hide' its being neglected. HTML: <div class="control-group hide login"> <label class="control-label" style="color:red">Username</label> <div class="control-group error"> <div class="controls"> <input type="text" class="input-large" name="username"> </div> </div> <label class="control-label" style="color:red">Password</label> <div class="control-group error"> <div class="controls"> <input type="password" class="input-large" name="password"> </div> </div> </div> jQuery: $(".login").hide(); $(".login").slideToggle("slow"); A: I solved the problem by replacing my html code as follows: <div class="control-group hide login"> <div class="control-group warning"> <label class="control-label" for="inputWarning">Username</label> <div class="controls"> <input type="text" id="inputWarning" name="username"> </div> </div> <div class="control-group warning"> <label class="control-label" for="inputWarning">Password</label> <div class="controls"> <input type="password" id="inputWarning" name="password"> <span class="help-inline"></span> </div> </div> </div> Even though it worked and solved my problem, i still cannot understand how? Any explanation welcomed!
Separation methods in the analysis of protein membrane complexes. The separation of membrane protein complexes can be divided into two categories. One category, which is operated on a relatively large scale, aims to purify the membrane protein complex from membrane fractions while retaining its native form, mainly to characterize its nature. The other category aims to analyze the constituents of the membrane protein complex, usually on a small scale. Both of these face the difficulty of isolating the membrane protein complex without interference originating from the hydrophobic nature of membrane proteins or from the close association with membrane lipids. To overcome this difficulty, many methods have been employed. Crystallized membrane protein complexes are the most successful example of the former category. In these purification methods, special efforts are made in the steps prior to the column chromatography to enrich the target membrane protein complexes. Although there are specific aspects for each complex, the most popular method for isolating these membrane protein complexes is anion-exchange column chromatography, especially using weak anion-exchange columns. Another remarkable trend is metal affinity column chromatography, which purifies the membrane protein complex as an intact complex in one step. Such protein complexes contain subunit proteins which are genetically engineered so as to include multiple-histidine tags at carboxyl- or amino-termini. The key to these successes for multi-subunit complex isolation is the idea of keeping the expression at its physiological level, rather than overexpression. On the other hand, affinity purification using the Fv fragment, in which a Strep tag is genetically introduced, is ideal because this method does not introduce any change to the target protein. These purification methods supported by affinity interaction can be applied to minor membrane protein complexes in the membrane system. Isoelectric focusing (IEF) and blue native (BN) electrophoresis have also been employed to prepare membrane protein complexes. Generally, a combination of two or more chromatographic and/or electrophoretic methods is conducted to separate membrane protein complexes. IEF or BN electrophoresis followed by 2nd dimension electrophoresis serve as useful tools for analytical demand. However, some problems still exist in the 2D electrophoresis using IEF. To resolve such problems, many attempts have been made, e.g. introduction of new chaotropes, surfactants, reductants or supporting matrices. This review will focus in particular on two topics: the preparative methods that achieved purification of membrane protein complexes in the native (intact) form, and the analytical methods oriented to resolve the membrane proteins. The characteristics of these purification and analytical methods will be discussed along with plausible future developments taking into account the nature of membrane protein complexes.
Feeds Hindus in Kerala Mahanavami has celebrated with joy and pious yesterday and held special prayers in temples and individual houses. The expedient of prayer halls have been erected on the side of the road and in public places such as reading clubs where prayers were offered to the goddess Saraswati, offering fruit and other food items. On the auspicious day of Durgashtami, people had observed a ceremony commonly known as Poojavaipu in temples and in homes. In kerala homes, offices and institutions books and other work related tools has been beautifully arranged in an auspicious manner and offered prayers to goddess for prosperity in the day to come. For the last two days the shops and markets were filled with goods for poojaveppu and special navarathri poojas.
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FLORHAM PARK, N.J.—Jacoby Ford remembers everything about the day the courtship began: The pickup from the airport. The shower of compliments. The steak dinner. And, of course, the invitation to head somewhere more private for a physical exam. As far as manners go, the New York Jets are gentlemen when it comes to wooing free agents. In the technology-savvy National Football League, where players now study Xs and Os on iPads rather than in playbooks, the Jets still employ an old-fashioned way of pursuing players during the off-season: They ply them with steak and booze. The Jets were frisky suitors in the past three months, winning over quarterback Michael Vick, running back Chris Johnson, right tackle Breno Giacomini and two receivers, Eric Decker and Ford. Coaches lavished the apples of their eyes with praise, and wined and dined at least three of the players in New Jersey's finest restaurants. They would consummate the relationship by inviting them back to the team's swanky training facility to take a physical and sign a contract.
Ligand nanovectorization using graphene to target cellular death receptors of cancer cell. Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is nowadays envisaged as a natural cytokine useful in nanomedicine to eradicate the cancer cells and not the healthy surrounding ones. However, it suffers from cell resistance and strong dispersion in body to prove its efficiency. The understanding at the molecular level of the TRAIL interaction with death receptors (DRs) on cancer cells is thus of fundamental importance to improve its action. We demonstrate here via molecular simulations that TRAIL can bind to its both agonistic DRs (ie, DR4 and DR5) with a preference for DR4. In this study, the role of a graphene nanoflake as a potential cargo for TRAIL is examined. Furthermore, both TRAIL self-assembling and TRAIL affinity when adsorbed on graphene are considered to enhance efficacy toward the targeted cancer cell. Our modelization results show that TRAIL can bind to DR4 and DR5 when transported by graphene nanoflake, as a proof of concept.
Various types of containers are used to receive and support delicate cargo such as electronic, computer, optical and other types of equipment. Example containers for such purposes may take the form of transit containers, rack-mount containers, tote containers or others. In some instances, containers of this type are used in military and commercial environments in which handling by persons or equipment may subject the containers to external forces from a variety of directions. Likewise, because the cargo may be valuable it is often useful to incorporate a lock or a means for locking the container. In some cases, containers of this type are designed to be stackable, and thus they may include stacking elements or features arranged in a desired pattern in order to restrict lateral movement of containers stacked atop other containers. Security for such containers can be an essential attribute and, in order to allow the containers to be locked for restricted access, a lock of some form is often provided on the container in order to lock the lid of the container securely atop the lower container body. In some instances, the lock is formed as a part of the container clasp system, with an integrated key-lock that requires use of a key to unlock the clasps in order to open the lid. In other instances (or together with locking clasps), a separate removable padlock may be attached at a location that will hold the lid firmly against the lower container body, preventing the lid from being opened without first removing the padlock. For example, the lid and lower container may each have laterally-extending flanges that abut one another when the lid is in the closed position, with one or more aligned holes being formed in each of the mating lid and container flanges. The shackle of the padlock can then be passed through the aligned holes in the lid and container flanges so that the shackle can then be inserted into the padlock case to lock the lid against the container. Current containers that provide a location for mounting a padlock do so in a way in which the padlock itself is exposed to abuse and is able to move through a large range of motion, allowing for potential damage to the lock and the portion of the case where the lock is attached. Depending on the severity of an external force applied to the case in the vicinity of the lock, the configuration of current structures may cause catastrophic damage to the lock or the case, thereby compromising the security of the case.
Q: "ant clean" doesn't clean my project in a way I can use After I run ant clean , my project still needs to be "cleaned" in Eclipse, before I can run ant release successfully. If I try to run ant release immediately after ant clean it will fail in the -compile component of the predefined build script on the contrary, if I run the Eclipse version of cleaning all the projects, then I run ant release the -compile component will not fail. Why is this? Why is ant clean a less adequate cleaning than the one Eclipse does? What can I do to fix this? A: There is no generic answer to this question. You will need to look at the implementation of the clean target in your ant script and figure out what it is doing wrong or not doing.
Bombings force Tube to put mobile phones on hold Share via PLANS to install mobile phone aerials at subterranean London Underground stations have been reviewed after it emerged that mobiles were used to trigger the bombs in Madrid last week. Tube managers had been planning to hold a trial later this year in which passengers would get a clear phone signal even when hundreds of feet underground. But the scheme may now be abandoned if it emerges that some of the bombs were activated by calls to mobile phones sitting inside the bags which were abandoned on packed commuter trains.
Injured Skier Sues Oregon Resort Over ‘Drunken’ Snowboarder If a restaurant can be held liable for a drunk driver causing bodily injury to others, then a resort owner can be held liable for a drunk snowboarder causing bodily injury to others. Ditto for intoxicated individuals operating a jet ski. We need to be consistent! Restaurants should not be liable for any individual’s behavior. The individual should be responsible for his/her own behavior. The only reason this ridiculous practice of holding a business liable for an individual’s behavior exists is that the business has “deep pockets” that can be picked clean by the trial bar. The money is all it’s about. Maybe if we started actually holding people accountable for THEIR OWN behavior instead of letting them blame others (oh, they shouldn’t have served me. boo hoo.) we wouldn’t have so many bogus lawsuits and the scumbag lawyers could go flip burgers or do whatever else they’re qualified to do. That’s worse than holding the police responsible for not catching a drunk driver. At least the p0lice have training in recognizing the signs of a drunk driver but they still can’t be held responsble for not seeing him.
Follow Cosmic Book News Brew's Crew: Crater Body (Editor’s note: This is another in a series of irregularly-scheduled columns by Managing Editor Byron Brewer, mainly dealing with cosmic comics and their many denizens. Mr. Brewer’s opinions do not necessarily reflect that of CosmicBookNews.com. He welcomes both raves and opposing views.) By Byron Brewer He was a Nova (the real Nova, not NINO) villain of few words and many actions. While there are few words I myself can write about him, this alien certainly deserves note. The strong, silent type, Crater was an alien of no words and all action, especially when it came to assaulting the last of the Nova Centurions, Richard Rider, after witnessing the death of fellow Luminal, Suspensor. Crater traveled with the rest of his group to the place called Knowhere in hopes they could eliminate the threat of their arch-foe, Abyss, forever. In a sad turn of events, Abyss slowly began to escape his prison and turned many of the citizens of Knowhere as well as Crater and the Luminals into his zombie slaves. Sadly, Crater was eventually destroyed along with the rest of Abyss’ army once Nova and his ally Cosmo sealed Abyss back in his prison. At that point, the Luminals under Abyss’ control along with the rest of the zombies dissipated into nothing. (Even so, nice remembering back to those days, eh?) Crater appeared to have superhuman strength and durability, the limits of which are unknown.
Deaf children creating written texts: contributions of American Sign Language and signed forms of English. The objectives of this descriptive study were to investigate the ways in which American Sign Language (ASL) and English-based sign allow for comprehension of text content, and to determine how these two avenues of communication might mediate the process of reconstructing "signed meaning" in a written text. The authors argue that comprehensible input in a visual mode is possible in either ASL or English-based sign. They further claim that English-based signing may be an effective means of bridging the gap between inner speech and written text.
Q: How is IValidate.GetInvalidRules supposed to work? we are currently trying to programmatically validate features against geodatabase-defined rules. This includes attribute rules as well as connectivity and relationship rules. We have consulted the documentation for IValidate, IValidation and the Validating features article on EDN to learn how it's done. After setting up the appropriate connectivity rules, invocation of the Validate Features in ArcMap correctly yields the number of invalid features in a selection. If I select a single feature, invocation of this command correctly displays what is wrong about that particular feature in a message box. Now, calling IValidate.Validate on that feature works as well. Its return value indicates that the feature is indeed invalid, and the error message is identical to that displayed by the Validate Features command in ArcMap. However, calling this method has two disadvantages which are problematic for our purposes: It performs the validation in a short-circuit manner. As soon as one of the assigned rules is invalid, it stops evaluating the remaining rules. We need to evaluate all the rules so that we can display the violations at once. It provides the error information as a string. For our purposes, we would ideally like to examine the information in a more structured way, which means we need to access the IRules that turned out to be invalid. So, this is where IValidate.GetInvalidRules comes into play. The documentation for this method states: The GetInvalidRules method returns an enumerator of rules that are currently violated by the row. which is exactly what we are after. However, the enumeration returned by this method does not seem to ever contain anything. What is particularly weird is that: Calling IValidate.Validate on a feature yields the appropriate validation error message as expected. Calling IValidate.GetInvalidRules on the very same feature always returns an empty enumeration as if no connectivity or relationship rules were invalid. (It does not matter whether the call is made within an edit session or not.) How can I validate a row against all the assigned geodatabase rules at once? Has anyone used IValidate.GetInvalidRules successfully? UPDATE: IValidate.GetInvalidRules seems to return invalid rules which pertain to attributes. However, invalid network connectivity rules are still never returned from this method. A: According to ESRI support, this behavior is indeed a bug.
Functional Constructivism: In Search of Formal Descriptors. The Functional Constructivism (FC) paradigm is an alternative to behaviorism and considers behavior as being generated every time anew, based on an individual's capacities, environmental resources and demands. Walter Freeman's work provided us with evidence supporting the FC principles. In this paper we make parallels between gradual construction processes leading to the formation of individual behavior and habits, and evolutionary processes leading to the establishment of biological systems. Referencing evolutionary theory, several formal descriptors of such processes are proposed. These FC descriptors refer to the most universal aspects for constructing consistent structures: expansion of degrees of freedom, integration processes based on internal and external compatibility between systems and maintenance processes, all given in four different classes of systems: (a) Zone of Proximate Development (poorly defined) systems; (b) peer systems with emerging reproduction of multiple siblings; (c) systems with internalized integration of behavioral elements ('cruise controls'); and (d) systems capable of handling low-probability, not yet present events. The recursive dynamics within this set of descriptors acting on (traditional) downward, upward and horizontal directions of evolution, is conceptualized as diagonal evolution, or di-evolution. Two examples applying these FC descriptors to taxonomy are given: classification of the functionality of neuro-transmitters and temperament traits; classification of mental disorders. The paper is an early step towards finding a formal language describing universal tendencies in highly diverse, complex and multi-level transient systems known in ecology and biology as 'contingency cycles.'
Redox is a Unix-like Operating System written in Rust, aiming to bring the innovations of Rust to a modern microkernel and full set of applications.
```release-note:enhancement redis: Add validation for name attribute in `redis_instance` ```
Q: DeploymentItem-Attribut for all files and folders in folder I want to deploy all files in folders which are in a directory within a unit-test. To deploy eacht item through the DeploymentItem-Attribut is too much. I tried something like [DeploymentItem(".\\")] or [DeploymentItem("*.*")] but both don't work. Does anybody knows how i can deploy all files with all subfolders by the Deployment-Attribut? A: DeploymentItemAttribute does not take a pattern to search and deploy. Read more about it here You need to use each of the file names for the same or create a custom attribute which takes a pattern and deploys the item to our output directory.
Activity-guided isolation of antioxidants from the roots of Rheum emodi. An activity-guided isolation and purification process was used to identify the DPPH free radical scavenging components of Rheum emodi. The activity-guided isolation revealed that eugenol, gallic acid, quercetin, rutin, epicatechin, desoxyrhapontigenin, rhapontigenin and mesopsin are the major phenolic compounds responsible for the antioxidant activity of the roots of R. emodi.
Easily reviewing PEP8 issues over Pull Requests - orkohunter https://github.com/OrkoHunter/pep8speaks ====== webmaven Nice! And useful, too. You should make this a "Show HN: ", though.
Change of weight-bearing pattern before and after plantar reconstruction with free anterolateral thigh flap. We reconstructed a large-sized defect at the weight-bearing plantar region by a free anterolateral thigh flap successfully. This is the first case report of using the anterolateral thigh flap for reconstruction of the plantar foot. Based on the preoperative and postoperative pedogram examinations, the pressure distribution on the weight-bearing area reconstructed by the transferred flap was obviously improved and demonstrated a nearly normal pattern. No previous report has compared the weight-bearing pattern before and after large plantar reconstruction with a free flap. The anterolateral thigh free flap, which provides adequate bulk and contour of the foot, and which withstands weight pressure and shearing force and has the ability to provide recovery of sensation, is considered a good alternative in covering a large weight-bearing plantar defect.
Marder vertreiben – So wirst Du Deinen Marder los Marder like people. She likes to visit her town even in the major city. Frequently the animals do not fall at all, since they are nocturnal and rest in their covering day. But they could be a problem. ” Marders prefer top of the floors, particularly the loft, for their hiding-places, and tend to be creating huge injury”, says Jürgen Eylert from the Research Middle for Hunting and Wildlife Protection in Bonn. And which can be expensive. Especially annoying is that marten search in to the tunnel passages of the top insulation. “Usually, in addition they ruin the underpass. And the underlying padding gets damp and drops its insulating influence, “describes Religious Anders from the Key Association of the German roofing deal in Cologne. That produces temperature connections, by which heated air escapes, and that drives the heating costs up. In the case of non-heated and non-heated roofs, there’s also the chance that molds form. Particularly bad is for all residents first the noise of the animals. “Running noises and rumbling in the attic are signs of a marten attack inside your marderfalle,” describes Eylert. Also excrements of feces and urine as well as remnants of carcass point to the uninvited guest. “If you don’t see the marten around an extended period of time, this may result in the smell of faeces and decay scattering in the whole house.” Steinmarder may rise very well and leap around two meters. Therefore you need to use woods or the flowers on your house wall to find a loophole inside your home, explains Eylert. Falls of rainwater and walls will also be climbing aids. “It doesn’t will have to be always a loophole to obtain underneath the roof,” says Derk Ehlert, Wild Pet Commissioner of the City of Berlin. A marten may also drive up much top hardwood to slip into the roof. There are numerous approaches to eliminate a marten – like, to make him immoral by creating the keep as unpleasant as possible. “Like, you can interrupt your night’s sleep with a noisy radio on your day or knock where in actuality the marten has its covering position,” suggests the zoologist Julian Heiermann from the Naturschutzbund Deutschland (NABU) in Berlin. Ultrasonic products also needs to have an impact, says Derk Ehlert. Some look at the record of the animals in stay instances as a great solution. Nevertheless, only somebody who has a shopping certificate, explains Jürgen Eylert. Marders are subject to shopping law. Additionally, the record of the creatures did not need a long-term achievement as either a brand new marten entertained the liberated area or the expelled marder moved long ranges to return to his home. It’s maybe not proven that budgetary suggests such as dog hair or urine of different animals support against marten infestation, claims Eylert. For if the marten doesn’t appear for quite a while, it are often he is currently searching for yet another of his numerous habitations in his territory. In the long term, expert authorities feel that marten can only just be avoided inside your home if the structures are inaccessible. Their loophole must therefore be discovered and closed. This can be done, for instance, by the fact that landowners set raked mud surfaces round the developing, causing records of the martens behind. Or your house owners search the flowers at the home for hints. If your loophole is shut, the pet should not be in the house. For if it’s caught, the marten can make an effort to use – and is creating damage, describes Anders. Or your pet starve. And as much as the animals are worrisome and troublesome – in the spring one should perhaps not secure out any martens. For they could have a boy who’d die painfully with no mother.
//@flow 'use strict'; import type {Props} from './lib.js'; class Class { constructor(props: Props) { const inputProps = { ...props, foo: 'bar', }; } } declare var x : mixed; //$FlowFixMe[sketchy-null-mixed] should suppress if(x) { };
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--- name: Feature Request about: Suggest an idea for this project custom_fields: [] --- ## I would like to request/propose a feature That's great. Let us know what's on on your mind and please try to be specific. You also can chat with us on Telegram [![@tgbots_dotnet](https://img.shields.io/badge/@tgbots__dotnet-Telegram-blue.svg)](https://t.me/tgbots_dotnet)
Teej in Gujarat Festival of Teej is a devotional and pious festival of women in Gujarat. It falls on the moonlit fortnight of sawan month (July/August). People splurge in the colorful festival of Teej and perform the rituals earnestly. Both married and unmarried women of Gujarat desperately wait for the season to begin the celebrations of the holy festival.. Teej Celebrations in Gujarat Teej is celebrated with same rituals and customs in Gujarat as performed in many other parts of the country. Since the state lies closer to Rajasthan so it has adopted many festivals from the colorful culture of the state. Teej is one such festival which is now celebrated as a major festival in Gujarat. Teej Festival preparations begin well in advance. The most attractive part of Teej celebration are Teej fairs. These fairs and markets are stocked with women ornaments, embellishments and other household stuff. Most of the Gujaratis are busy shopping for Teej celebrations when the festival is near. In most towns and villages, processions are taken out with beautifully adorned elephants and horses to celebrate the festival. At some places, special Gujarati dance performances are also organized. Women perform garba and dandia dance in traditional lehanga-choli. Teej for Womenfolk Teej is a woman centric festival. To celebrate the auspicious occasion, married women return to their parents house. On Teej, women observe fasts for the longevity and well-being of their husband. Long queues of devotees can be seen outside various Shiva temples to worship Lord Shiva and Goddess Parvati - symbols of an ideal marriage. Beautifully decorated swings are hung from trees or in the courtyard of the house which recreate memories of childhood. A special sweet dish called seviyan is prepared on Teej in various parts of Gujarat. Women dressed up in colorful sarees, lehangas and suits sing traditional folk songs. Gujarati women dress themselves in different colors depicting the symbol of married life. One can see them in the auspicious green, yellow and red colored duppattas with zari and gota work on it. Most of them wear red colored sarees with a front pallu or vibrant lehanga-choli. Some women in Gujarat specially practice steps from garba or dandia and perform them in celebrations after Teej puja ceremony. Just as in other states, married and engaged women in Gujarat also receive sweets and clothes from their parents and parents in-law. This is considered as a marital blessing for long and happy life of their husband.
In Detail Mongoid helps you to leverage the power of schema-less and efficient document-based design, dynamic queries, and atomic modifier operations. Mongoid eases the work of Ruby developers while they are working on complex frameworks. Starting with why and how you should use Mongoid, this book covers the various components of Mongoid. It then delves deeper into the detail of queries and relations, and you will learn some tips and tricks on improving performance. With this book, you will be able to build robust and large-scale web applications with Mongoid and Rails. Starting with the basics, this book introduces you to components such as moped and origin, and how information is managed, learn about the various datatypes, embedded documents, arrays, and hashes. You will learn how a document is stored and manipulated with callbacks, validations, and even atomic updates. This book will then show you the querying mechanism in detail, right from simple to complex queries, and even explains eager loading, lazy evaluation, and chaining of queries. Finally, this book will explain the importance of performance tuning and how to use the right indexes. It also explains MapReduce and the Aggregation Framework. Approach A step-by-step tutorial with focused examples that will help you build scalable, high performance Rails web applications with Mongoid. Who this book is for If you are an application developer who wants to learn how to use Mongoid in a Rails application, this book will be great for you. You are expected to be familiar with MongoDB and Ruby.
Q: Mongoose - populate with other then id I have these two simplified schema which I'd like to "join" based on ip address. var personSchema = Schema({ name: String, ip: String }); var logSchema = Schema({ message: String, ip: String }); It would work if person._id was the ip address. But it's not an options for me. Currently I've solved the problem the way that when new log is saved, I search the person and add reference to log. Schema is then like this: var logSchema = Schema({ message: String, ip: String, person: { type: Schema.Types.ObjectId, ref: 'Person' } }); I've read mongoose Populate documentation, Document#populated and Model.populate(). I'm still not sure if it is possible or not. This example is very simplified, I use mapReduce and grouping on log collection and therefore population would be great for me. I've also read Database references and it seems to me that the only option is to populate based on _id. But it's pure mongodb and maybe there is another possiblity using mongoose? Is it possible to populate query not based on _id field? A: MongoDB does not support joins. So .populate just makes another query, therefore the best solution for you is to make another query manually.
Q: Getting the Selected Item among items present in Grid I am implementing a Media Player application using WPF. I want to display a List Screen where the user can select the video from a list. I want to display the videos in a list horizontally(without scrollbars so not using ListView) where each item consists of a thumbnail, title and duration. Now I also want to obtain which item was clicked on so as to play the correct video. I tried to display the items in a WrapPanel which sufficed for display but doesnt have a SelectedIndex property. Will a Grid be helpful in this regard? If yes then how do I obtain which item was selected in the Grid? A: Use a ListBox. WPF UI elements keep their appearance separate from their functionality. If you want a list of items where you can select one, use a ListBox. If you want to customize how it looks, simply change its Template. Grid, WrapPanel, StackPanel and the like are just Panel UI element which are used for Layout. They don't derive from Selector and thus don't have any item selection features. Since you didn't post any relevant XAML in your question, I'll not post any relevant XAML in my answer.
Mosaic amplification of multiple receptor tyrosine kinase genes in glioblastoma. Tumor heterogeneity has been implicated in tumor growth and progression as well as resistance to therapy. We present an example of genetic heterogeneity in human malignant brain tumors in which multiple closely related driver genes are amplified and activated simultaneously in adjacent intermingled cells. We have observed up to three different receptor tyrosine kinases (EGFR, MET, PDGFRA) amplified in single tumors in different cells in a mutually exclusive fashion. Each subpopulation was actively dividing, and the genetic changes resulted in protein production, and coexisting subpopulations shared common early genetic mutations indicating their derivation from a single precursor cell. The stable coexistence of different clones within the same tumor will have important clinical implications for tumor resistance to targeted therapies.
[Systemic approach to radiobiological studies]. The principles of information theory were applied for analysis of radiobiological effects. The perception of ionizing radiations as a signal enables living organism to discern their benefits or harm, to react to absolute and relatively small deviations, to keep the logic and chronicle of events, to use the former experience for reacting in presence, to forecast consequences. The systemic analysis of organism's response to ionizing radiations allows explaining the peculiarities of effects of different absorbed doses, hormesis, apoptosis, remote consequences and other post-radiation effects.
Q: Restrict s3_direct_upload to specific filetypes I have a quick question. I'm using the s3_direct_upload gem to facilitate uploads to my s3 bucket. I'd like to restrict uploads to PDFs only. How can I go about this? Thanks! A: See the gem's documentation, Jquery plugin options section. It looks like you would add a before_add callback function that checks to ensure the filename ends in .pdf, and returns false if it doesn't.
Q: Enhanced for loop and null check of objects lets say i have the following code: for (AnyObject anyObject : anyObjectList) { System.out.println(anyObject.doSomething()); } My question is: I read that its possible to add null to at least some kind of list types. If im right: shouldn't be there always a null check before you access the method of the iterated class? Im just asking because i have never seen so far a enhanced for loop with a null check like this for example: for (AnyObject anyObject : anyObjectList) { if (anyObject != null) { System.out.println(anyObject.doSomething()); } } A: Actually you'd often want to know if there is a random null in your list when there shouldn't be. Your first snippet will throw an exception indicating the problem, but your second will consume the error silently. You could also do something like this: for (AnyObject anyObject : anyObjectList) { if (anyObject != null) { System.out.println(anyObject.doSomething()); } else { /* something went wrong -- report error, debugging info, etc. */ } }
Conventional skateboards utilize pivoting truck assemblies attached to a solid wood riding deck. These truck assemblies typically include a shaft, cups, elastomeric bushings, washers, mounting plates, a single axle, bearings, two elastomeric wheels and fasteners. The skateboard rider steers the skateboard by leaning and applying pressure to opposite lateral sides of the skateboard deck, which in turn causes the truck assembly to pivot and rotate the single truck axle about a single axis perpendicular to the skateboard deck. Conventional truck assemblies provide a fairly rugged and reliable assembly, but suffer from a number of disadvantages including: a) the turning ability of existing skateboards is very limited due to existing truck designs and b) existing skateboards have no provision to adjust steering response to the amount of angle and pressure the rider applies to the deck. Existing truck assemblies typically include two wheels attached to a single axle. This arrangement allows only small axle rotation resulting in very limited skateboard turning capability. To execute tight turns, the rider must perform the awkward maneuvers of forcing the back end of the skateboard down which lifts the forward truck assembly off the surface on which it is riding and rotating the skateboard about the rear truck assembly. Less experienced skateboard riders must sometimes stop the skateboard, lift the skateboard off the ground and reposition it in its new direction. This is especially true around very tight turns. While some improvement in skateboard turning capability is possible by changing the truck's elastomeric bushing material and shaft tightness, this improvement typically has the undesirable effect of causing skateboard wobble, wheel “bite” (the wheel hits the deck causing the skateboard to stop rapidly) and instability. Additionally, for every degree of deck rotation the rider applies, a fixed amount of turning radius results. If for instance a rider wants very large changes in steering radii with relatively small changes in initial deck rotation and then smaller changes in steering as more deck rotation is applied, existing skateboards cannot satisfy this need. Existing skateboards provide only a fixed, linear steering output in relation to skateboard rider input. To overcome the disadvantages of conventional truck assemblies, it is desirable to provide a truck assembly that permits very tight, small turning radius capability without the need to lift the forward truck assembly or the entire skateboard from the surface on which it is riding. Such a truck assembly may maintain stability and eliminate wobble and wheel bite for all truck settings and adjustments. It is also desirable to provide a truck assembly that permits variable and adjustable steering response. Such adjustability may be utilized, for example, to allow small deck rotations to provide large changes in skateboard steering radii or vice verse, i.e., to allow large deck rotations to make small changes in steering radii.
Ryan Peter. Writer. Ghostwriter. Author. Journalist. Apologetics influences theology Many of the early church fathers, including Augustine, formed theology through the realm of apologetics. Their apologetics then became accepted theology. This seems to be the case. You can’t really separate theology and apologetics, because the apologetic wants to present a clear-cut case of theology, but in doing so he can affect theology. Well, to illustrate my point, let me give you an example. In discussions with an atheist on the Internet we were arguing about the foreknowledge of God. I was saying that just because God has absolute foreknowledge of an event doesn’t mean God purposed for the event to happen, nor does it mean we don’t have choices in life. He was saying that if an event is “destined” to occur it is predetermined. There’s nothing I can do to change the event. I have the illusion of choice but I don’t really have the ability to change the event – so do we REALLY have free will? We have the illusion of free will, yes. I argued my point thoroughly that foreknowledge of an event does not necessarily mean the event is predetermined only to realise he was right and I was wrong. The event IS predetermined. The biggest problem for the foreknowledge of God is the relation of foreknowledge to human freedom. If God knows that something will happen, then it will happen. That is, if God knows the event to be a historical reality, then that event must occur; it is predestined. If it does not occur than God did not know. If you have time to read the article, you should. Basically, Bratcher advocates that the absolute foreknowledge or omniscient model is not exactly wrong, just perhaps not the whole story. A better model would be incarnation, and he attaches this to the realm of prophecy, referring to certain prophecies in the Bible that didn’t come true the way the prophet initially prophesied it, but it did come true in just a different way (a different nation etc.). I’m aware of Gregory Boyd’s work into the concept that God, in his sovereignty, actually chooses not to know the future absolutely but rather the infinite possibilities of every choice. This means the future is not determined, and not even God really knows which choice I’m really going to make. He knows all of the infinite possibilities and has a plan for all of them, but ultimately my freedom is my freedom. I find it fascinating and intriguing, and some of the apologetics on Boyd’s site and Bratcher’s are incredibly compelling. The problem is that this presents theology that is unconventional and sometimes seen as heretical. In an earlier post I mentioned that we’re all going to be a heretic to someone, eventually, so I guess we have to accept that. The issue is what do we DO – if an apologetic presents a compelling case, based on the Scriptures and reason, that goes slightly against (or even opposite) to the “accepted” theology on the topic, what do we do? If the case is so compelling it may bring skeptics to faith in Christ, what do we do? What do I do in my own apologetics? When am using “heresy” to bring people to Christ, and is that wrong? Right? Are we not making a big deal out of periphery stuff? This is a conundrum. Should I defend certain theology just because it’s the “accepted” theology, but doesn’t stand up to intellectual scrutiny of the day? Or should we be forming new theologies based on new apologetics and intellectual discoveries? Why is it so difficult to say that Augustine may have been wrong, or he wasn’t necessarily wrong he just didn’t have the whole picture – or the questions been asked were entirely different? One thing that Bratcher mentions is how the new generation asks different questions, but we attempt to answer it with the answers to older questions. Yet, in the process of answering the new questions – new because the new generation is mainly post-modern or existential in its outlook – how much does this affect theology? And what should theologians, pastors, etc. do about it? What should writers do about it? 😉
[Radiation-induced pacemaker malfunction]. As the number of implanted pacemakers and the incidence of malignant tumors increases, the probability of radiation-mediated pacemaker dysfunction increases. Radiation can substantially damage pacemaker electronics. We report here a case, with loss of communication after radiation therapy.
Book travel Challenging, hilly trails for joggers, with bulbous rock formations and thick forests. The reservoir at the west end of the park attracts hordes of people in summer. Šárka is most easily accessible from Evropská, towards the airport.
A swarm of multirotor UAVs for surveys in poor GPS/GNSS wild areas Monitoring of wide wild natural areas sometimes is really important for natural preservation purposes so as for developing surveys where no manned terrestrial vehicles are allowed. Unmanned vehicles are precious means to discover and collect data in these peculiar situations, but loss of GPS/GNSS signal can make this strategy sterile and hard to be practised. Giving specific roles to the diverse aerial components of the swarm, a sort of hierarchy can be created in which a master UAV rules in case of loss of GPS/GNSS providing information about position and orientation to the rest of the swarm. A kind of flying temporary signal source for the continuity of the survey process is established in this way. Relevant applications in wild natural areas still existent in some parts of the world and in extremely dangerous regions can be thought also thanks to the exploitation of long range transmission solution for drones.
Imaging of Urinary System Trauma. Computed tomography (CT) imaging of the kidney, ureter, and bladder permit accurate and prompt diagnosis or exclusion of traumatic injuries, without the need to move the patient to the fluoroscopy suite. Real-time review of imaging permits selective delayed imaging, reducing time on the scanner and radiation dose for patients who do not require delays. Modifying imaging parameters to obtain thicker slices and noisier images permits detection of contrast extravasation from the kidneys, ureters, and bladder, while reducing radiation dose on the delayed or cystographic imaging. The American Association for the Surgery of Trauma grading system is discussed, along with challenges and limitations.
The oncogene and developmental regulator EVI1: expression, biochemical properties, and biological functions. The EVI1 gene codes for a zinc finger transcription factor with important roles both in normal development and in leukemogenesis. Transcriptional activation of this gene through chromosome rearrangements or other, yet to be identified mechanisms leads to particularly aggressive forms of human myeloid leukemia. In vitro as well as in animal model systems, EVI1 affected cellular proliferation, differentiation, and apoptosis in cell type specific ways. Retroviral integrations into the EVI1 locus provided cells with increased abilities to engraft, survive, and proliferate in bone marrow transplantation experiments. Experimental overexpression of EVI1 by itself was insufficient to cause leukemia in animal model systems, but it cooperated with other genes in this process. This review summarizes the currently available experimental evidence for the proposed biochemical and biological functions of this important oncogene.
Thank you, everyone. I couldn’t ask for higher words of praise. But endorsements are now pouring in from all sides, including Warner Brothers who just snapped up the movie rights. John C. Reilly had agreed to play me. Steve Portigal’s part will be played by Brandon Routh, Fourobotros by Ralph Fiennes, LK by Jennifer Garner, Ed Batista by Jake Gyllenhaal, MEL by Jon Stewart, with other parts still to be filled. Grant
Interpersonal and family functioning of female survivors of childhood sexual abuse. The empirical literature that addresses the association between childhood sexual abuse (CSA) and the interpersonal functioning of female survivors within their adult family context is critically examined. Specifically, research on relationship difficulties, problems in attachment, marital conflict and divorce, secondary traumatization, sexual dysfunction, maternal attitudes and functioning, and the heightened risk for having children who themselves are sexually abused is reviewed. There is converging evidence in both clinical and community samples that, compared to other women, female CSA survivors do experience more relationship problems and more problems in sexual functioning. Based on community samples, there is an indication that CSA survivors experience problems in marital functioning and attachment. Beyond this, little sound research has addressed the issues of secondary traumatization, maternal attitudes, maternal functioning, or intergenerational patterns of abuse. The use of specificity designs, improved sampling strategies, and standardized, psychometrically strong measures in future research would greatly improve the quality of our knowledge on the interpersonal and family functioning of CSA survivors.
Jamesburgh Jamesburgh may refer to: Jamesburgh, California, former name of Jamesburg, California Jamesburgh, New York, former name of Walker Valley, New York
# Summary * [基础认知](./基础认知.md) * [基础类型](./基础类型.md) * [接口与类](./接口与类.md) * [函数](./函数.md) * [泛型](./泛型.md) * [枚举与类型](./枚举与类型.md) * [Symbol 与模块](./Symbol 与模块.md) * [装饰器与混合对象](./装饰器与混合对象.md) * [声明合并](./声明合并.md) * [tsconfig.json](./tsconfig.json .md)
[Coverage of anterior knee defect by reverse flow anterolateral thigh flap: About two cases]. The coverage of soft-tissue defects concerning the front of the knee and the proximal lower leg is a complex procedure. The reverse flow anterolateral thigh flap represents a good solution for this defects, especially when the coverage surface is large-sized and a free flap is not appropriate regarding the difficulty of the process. Flap retrograde vascularization is based on the anastomosis between the descending branch of the circumflex femoral artery and lateral superior genicular artery. It is an easy solution with low morbidity. The authors have chosen this flap to cover soft-tissue defect of anterior knee from two patients with total knee prothesis.
Q: android: add line to each item in List View I have created the simple list view with base adapter.Now I want to add the simple line after the each item in list view.can anyone please tell how to do it. Thank you. A: Hi This done using the http://developer.android.com/reference/android/widget/ListView.html#attr_android:divider Please not forget to set the android:deviderHeight otherwise it will not show. Thank for support
Q: Filter a field containing a value I'm starting to learn SQL. Im using SQL Server Management Studio to write my queries in. I unserstand that I can filter a field contaning a given value (for example : product A, product A (cost), product B, product B (cost)) so in this instance I can filter out values containing "(cost)". I've arrived at the following query but its failing. Can you tell me why. SELECT billing_code, billing_code_desc FROM dbo.jm_billing_code WHERE (NOT (billing_code_desc = N'CONTAIN [(cost)]')) ORDER BY billing_code A: N'CONTAIN [(cost)]' is a string literal, you can't place functions like contain in there. Try this instead: where billing_code_desc not like '%(cost)%' A: To exclude results that have cost: SELECT billing_code, billing_code_desc FROM dbo.jm_billing_code WHERE billing_code_desc NOT LIKE '%(cost)%' ORDER BY billing_code
Following table contains commonly use operators; Notice that Visual Basic, using more operators than Java; HARDWARE related i.e. calculator, dictionary, translator, GPS, Idea Processor, ... , operators are also included in this table; Being a significant part ... ;
Five Things Animals Would Say If They Could by Kitty Jones "Vegan options"?! I need you to fight for me! We must fight for the individuals being exploited and murdered by animal agriculture. In the consumer-centered world we live in, veganism has become a marketable and trendy "lifestyle." However, we must not confuse vegan consumerism and vegan options for animal liberation. As activists, it is our jobs to fight for the animals, not for consumer products. ...Ben & Jerry's has vegan ice cream...good for you. They also killed my mother. While many animal advocates are celebrating that Ben & Jerry's is going to offer vegan ice cream flavors in the future, which I am sure will be delicious…how do the animals feel about this? For them, vegan ice cream means nothing because they are still being born in the prisons we call farms, and their families are still being killed. We must fight for the victims of animal agriculture as we would fight for the animals that we know and love in our own homes. What would we do if our dogs were the ones being exploited for their breast milk? It is not about you. Activism is not a hobby or a way to be cool, activism is a commitment to justice. The activism we do is not about us, it is about the victims. We fight for animal liberation, we fight for a better world for ALL animals – including human animals – because we must. Don't forget who you are fighting for. We will achieve animal liberation, I am sure of that, but we must leave our egos behind. We are in this fight together and we are in it for all of us, not just ourselves. You have time to go to the protest. Activism is a lifelong commitment. We must make time and not excuses to fight for animal liberation. The systems, corporations and ideologies that perpetuate human supremacy and speciesism are not going to go away voluntarily – we must challenge and disrupt them. If you are able to, make the time to go to the protest, community event, or other activist event. The animals need you. Veganism without justice will never set me free. Being vegan is absolutely essential, but it is not the best that we can do. Companies and brands actively try to commodify and market veganism. It is vital that we remind the world that veganism is not a diet, veganism is not a personal choice, and veganism is not a trend. Rather, veganism is actively taking a stand for the animals. Veganism is fighting until every animal is safe, happy, and free.
A new hope: the immunotherapy in small cell lung cancer. Small cell lung cancer (SCLC) is of a high-grade malignancy with a high metastatic potential and poor clinical prognosis. Unfortunately, SCLC initially exhibits a good response to chemotherapy and radiation therapy, but inevitably, relapses decrease patients' chance of survival. Despite tremendous advances on the development of new chemotherapeutic agents, the prognosis of this disease remains poor. Immunotherapy plays a role in eliciting an anticancer response by modulating the patient's immune response of the tumor. Several studies have demonstrated that abnormal autoimmune regulation has a close relationship with SCLC. Thus, several immunotherapy trials are focused on SCLC treatment, including such approaches as immune checkpoints blockers, tumor vaccine, antigenic targets and adoptive cellular immunotherapy to benefit patients with SCLC. To date, the results from immunotherapy in SCLC have not been promising. For example, tumor vaccines have not been demonstrated to have a significant survival benefit. However, there have been many promising advances with immune checkpoints blockers. This review will provide a general overview of immunotherapy in SCLC. The landmark clinical trials in previous successful immunotherapy studies are summarized here. Finally, the challenges of immunotherapy in SCLC are discussed to facilitate the prediction of possible and valuable strategies for future therapy.
Polyoma virus disrupts ARF signaling to p53. Polyoma virus (Py) differs from other small DNA tumor viruses in not encoding a protein that inactivates p53. The complete Py early region encoding the large T-antigen (PyLT), middle T-antigen (PyMT) and small T-antigen (PyST) will transform primary rodent cells and REF52 cells, but PyMT, the main Py oncogene, by itself will only transform these cells when p53 or ARF is inactivated. We have related Py oncogene cooperation with the effects of the Py T-antigens on the ARF-p53 signaling pathway. PyMT activates an ARF-induced p53-mediated block to cell division explaining the inability of PyMT alone to generate dividing transformed cells. In contrast, in REF52 cells transformed by the whole Py early region (PyREF52), ARF is upregulated but p53 is not activated. Thus PyLT and/or PyST negates the PyMT-induced ARF-mediated block to cell division by disrupting the signaling pathway from ARF to p53. Although there is no detectable interaction or co-localization of endogenous ARF (nucleoli) and MDM2 (nucleoplasm) in PyREF52 cells, expression of transfected ectopic ARF results in an MDM2/ARF interaction and sequestration of MDM2 into the nucleoli. Sequestration of MDM2 by ARF in the nucleoli is not essential for a p53 response in REF52 cells as activation of Raf in REF52Raf-ER cells results in an ARF-induced p53-mediated cell cycle block in the absence of a detectable ARF-MDM2 interaction. Py may provide new insights into the cellular ARF-p53 signaling pathway.
A short wildlife documentary by Africa Media intern Shorouk El-Zeftawy. Shorouk follows the young male lion Tau in his pride . Unless Tau challenges the alpha male for dominance he will be removed and relocated from his pride.
Beatson concluded there is projection of power in the way China has built up and deployed port, merchant shipping, and naval assets, in addition to the economic logic of doing so. A recognition of the need to deal with Chinese vulnerability, particularly in respect of protecting the flow of commodity imports, especially energy, forms a part of the practical basis of the expansion.
#ifdef STM32F4xx #include "stm32f4xx_ll_lptim.c" #endif #ifdef STM32F7xx #include "stm32f7xx_ll_lptim.c" #endif #ifdef STM32G0xx #include "stm32g0xx_ll_lptim.c" #endif #ifdef STM32G4xx #include "stm32g4xx_ll_lptim.c" #endif #ifdef STM32H7xx #include "stm32h7xx_ll_lptim.c" #endif #ifdef STM32L0xx #include "stm32l0xx_ll_lptim.c" #endif #ifdef STM32L4xx #include "stm32l4xx_ll_lptim.c" #endif #ifdef STM32MP1xx #include "stm32mp1xx_ll_lptim.c" #endif #ifdef STM32WBxx #include "stm32wbxx_ll_lptim.c" #endif
Using quantitative acid-base analysis in the ICU. The quantitative acid-base 'Strong Ion' calculator is a practical application of quantitative acid-base chemistry, as developed by Peter Stewart and Peter Constable. It quantifies the three independent factors that control acidity, calculates the concentration and charge of unmeasured ions, produces a report based on these calculations and displays a Gamblegram depicting measured ionic species. Used together with the medical history, quantitative acid-base analysis has advantages over traditional approaches.
Coyotes infected with sarcoptic mange, which can make them look like “some sort of ‘zombie’ dog,” are being confused for stray pets in the suburbs, Hanover Park police say. “Recently we have received several messages and posts from citizens concerned about what appear to be malnourished or neglected stray dogs,” a Facebook post on the department’s page Thursday reads. “These are NOT lost pets, but are in fact coyotes.” The department says there is an increase in the disease in urban coyote populations which makes the normally nocturnal coyotes come out during the day. Infected coyotes will appear “mangy,” often hairless and haggard. “These infected animals are not normally aggressive, but should be avoided at all times,” the department says. “Please DO NOT approach these animals or allow your pets to approach them.” Police say residents can best keep the animals from yards and neighborhoods by securing garbage cans and not leaving food outside. There hasn’t been a single coyote bite or attack on humans reported in northeastern Illinois, according to Cook County’s urban coyote ecology and management website. “Domestic dog bites are far more common than bites by wild animals,” the site reads. If a resident is concerned that a coyote may be a “nuisance,” the county suggests calling the police, animal control or Department of Natural Resources.
Doctors in management. Career view mirror. A survey of doctors and managers found agreement that management training should be given at various stages of a doctor's career. Managers felt strongly that doctors should receive management training in groups with other staff. Doctors believed clinical budgets should be under doctors' control, but managers were opposed to this. The results suggested that a 'them and us' culture persists between managers and doctors in the NHS.
Field of the Invention The invention relates to a variable capacitor and a method for manufacturing the same. Description of the Related Art A variable capacitor is a capacitor whose capacitance can be changed mechanically or electronically. Electronically controlled variable capacitors usually employ power electronic switches to adjust the capacitance values. This results in interference when the power electronic switches are switched on and off. In addition, mechanically controlled variable capacitors often have a large size and a narrow capacitance range.
AIEgens for biological process monitoring and disease theranostics. Biological processes are of great significance for the normal physiological functions of living organisms and closely related to the health. Monitoring of biological processes and diagnosis of diseases based on fluorescent techniques would provide comprehensive insight into mechanism of life and pathogenesis of diseases, precisely guiding therapeutic effect in theranostics. It largely relied on fluorophores with the properties of excellent photostability, large Stokes shift, high signal-to-noise ratio and free of aggregation-caused quenching (ACQ) effect. Luminogens with aggregation-induced emission characteristic (AIEgens) could serve as superior agents for biological process monitoring and disease theranostics. Herein, we review the recent results in the aspects of monitoring biological processes such as autophagy, mitophagy, mitochondrion-related dynamics, cell mitotic, long-term cellular tracing and apoptosis as well as the diagnosis of related diseases based on AIEgens in real time. As part of AIEgens and AIEgen-based nanoparticles with the functionalities of drugs, photosensitizers and adjuvants accompanied with imaging, they exhibit huge potential in theranostic systems for image-guided chemotherapy, photodynamic therapy, radiotherapy and so on. Collectively, these examples show the potentials of AIEgens for understanding disease pathogenesis, for drug development and evaluation, and for clinical disease diagnosis and therapy. Future research efforts focused on developing long-wavelength excitable and phosphorescence-emissive AIEgens with improved depth-penetration and minimized background interference for fluorescence and photoacoustic imaging, will extend the potential applications of AIEgens in in vivo.
To have clean and re-usable Groovy Server Pages (GSP) we can use templates on our pages. A template contains HTML and code that we can maintain separately. In this post we learn about the template namespace to include a template on our page. Suppose we have a page in our application that display a list of products. Each product has several properties we show. The template for a product is: <%-- File: grails-app/views/product/_productView.gsp --%> <li class="${cssClassName}"> ${product.identifier} ${product.name} <g:formatNumber number="${product.price}" type="currency" currencyCode="EUR"/> </li> We can use the template with the g:render tag and template attribute on our page: <%-- File: grails-app/views/product/list.gsp --%> ... <ul> <g:render template="productView" var="product" collection="${products}" model="[cssClassName: 'info']"/> </ul> ... <ul> <g:each in="${products}" var="product"> <g:render template="productView" model="[product: product, cssClassName: 'info']"/> </g:each> </ul> ... But we can also use the template namespace feature in Grails. We define a tag with the namespace tmpl and the tagname is our template name. We pass the model for the template through the attributes. Each attribute name/value pair is passed as model to the template. <%-- File: grails-app/views/product/list.gsp --%> ... <ul> <g:each in="${products}" var="product"> <tmpl:productView product="${product}" cssClassName="info"/> </g:each> </ul> ...
An engine brake, an Jake brake, and an exhaust brake, etc. have been used in commercial vehicles as an auxiliary brake to assist a foot brake with more secured braking force by reducing power transmitted to a crank shaft. The engine brake among the above listed brakes, decelerates a vehicle by preventing driving force generation to forcibly open an exhaust valve at a compression top dead center and discharging a compressed air to atmosphere to prevent piston movement by the compressed air when an acceleration pedal is released during a four cycle (an intake stroke→a compression stroke→an explosion stroke→an exhaust stroke). The engine brake uses negative pressure resistance acting on a piston during the intake stroke, compression resistance during the compression stroke, compression resistance during the exhaust stroke, and a mechanical friction force generated during engine rotation, as a braking force. Such an engine brake is mounted at an upper portion of an engine and connected to an exhaust cam, an exhaust rocker arm, intake/exhaust valves, and an engine oil circulation structure of a cylinder head. However, the engine brake can only be mounted in the engine at which an exhaust cam having a protrusion is applicable since movement of the exhaust rocker arm pressing down the exhaust valve before reaching the compression top dead center is directly connected with the exhaust cam having the protrusion. Accordingly, an improved variable intake/exhaust valve system capable of satisfying the fuel efficiency has been applied to the engine brake connected with the engine cam having the protrusion. However, the compression top dead center of the exhaust cam having the protrusion in the variable intake/exhaust valve system cannot be determined.
Macrocheilia due to lymphangiectasia. A case of symmetrical, diffuse macrocheilia due to lymphangiectasia is presented. No primary cause for this case or for many other pathologic forms of macrocheilia has been established. Tranverse mucosal wedge resection of the lip with mucosal advancement, however, is a satisfactory method of treatment.
Or, if your project doesn't use Cabal, then there is limited support for using an overall module from your program/library: SourceGraph path/to/Foo.hs Note that the Cabal method is preferred, as it is better able to determine the project name and exported modules (when passing a Haskell file to SourceGraph, it uses that module's name as the overall name of project and assumes that it is the only exported module; as such, it works better for programs than libraries). Whichever way you run SourceGraph, it then creates a SourceGraph subdirectory in the same directory as the file that was passed to it, and within that subdirectory creates the analysis report in Foo.html. SourceGraph is still experimental in terms of its ability to parse and properly understand Haskell source code and in the types of analyses it performs.
William L. Patberg Assistant William L. Patberg has over thirty years of experience in both the administrative and judicial aspects of the environmental law representing clients of all sizes in a wide variety of industries. His principal areas of practice are air and water pollution control matters. In connection with this practice, Bill has been admitted to and has appeared before the U.S. Supreme Court, the United States Courts of Appeals for the Third, Sixth, Seventh and D.C. Circuits, the United States District Courts for the Northern District of Ohio and the Northern District of Indiana, the Ohio Courts of Common Pleas, Courts of Appeals, and Supreme Court, the Ohio Environmental Review Appeals Commission, and, pro hac vice, the Appellate Court of Illinois, 1st Judicial District and the Indiana Office of Environmental Adjudications. He has regularly appeared before and has been involved in negotiations with the United States Environmental Protection Agency and the Ohio, Indiana, Michigan, Illinois and Pennsylvania and Florida environmental agencies in connection with a wide variety of different rulemakings, permits, enforcement and other administrative proceedings. He has extensive experience assisting companies in identifying and anticipating their compliance obligations, in developing and obtaining agency approval of cost-effective means of achieving their business goals in a manner consistent with environmental requirements, and in defending companies against claims of noncompliance brought by federal and state agencies and environmental groups. Bill is a frequent speaker at federal, state and local symposia and seminars on a wide variety of air and water pollution control issues. Bill is currently primarily focused on representation of refining industry clients and assisting those clients in complicated New Source Review and permitting matters, as well as U.S. EPA’s continued efforts at New Source Review enforcement matters in the refining industry.
Improving communication with cancer patients. If doctors and nurses involved in cancer care are to help patients and their families achieve an optimal level of quality of life and psychological adjustment they must be able to carry out key communication tasks successfully. Yet, objective scrutiny of their consultations confirms that deficiencies in their ability to conduct these tasks remain. The reasons for this are discussed before important innovations in training and their impact are described.
Q: How to get .babelrc from sub package? How can I get .babelrc from sub package? I don't want it my main package. I want from node_modules/mySubPackage/node_modules. Thank you. A: You could use babelrcroots, From the documentation: By default, Babel will only search for .babelrc files within the "root" package ..... This option allows users to provide a list of other packages that should be considered "root" packages when considering whether to load .babelrc files.
With the rapid development of information techniques and computer techniques, computer users have higher requirements of the performance of computer systems. Thus, in order to avoid performance bottleneck including hardware bottleneck and software bottleneck in the computer systems, it is required to evaluate and analyze the performance of the computer systems, so as to provide corresponding performance optimization solutions, upgrade hardware and software of the systems and/or improve system architectures, thereby obtaining feasible hardware and software configurations and making utilization of computer resources balanced. Generally, in order to evaluate the performance of the computer systems, profiling is performed to collect information such as process status in the system and how much CPU resources are used by different processes, modules and threads, respectively. Such information can be collectively referred to as profiling data. After the profiling data is analyzed by users, system administrators or system performance analyzers of the computer systems with existing analysis tools, improvement can be done on some important components of the computer systems, such as sharable runtime libraries, or compilers. Depending on the profiling duration and the number of running processes, threads and so on in the systems, the size of profiling data files obtained from the profiling varies from several megabytes to hundreds megabytes. Since system performance analysis is often based on aggregate profiling data, the profiling data is required to be read out, calculated, organized, or even transformed. In existing techniques of computer system performance analysis, in order to satisfy the above requirements, traditionally, analysis tools need to pre-read all the contents of the profiling data and then create a target data model in a memory for subsequent analysis as needed. However, this may cause many problems. For example, since files of the profiling data are required to be transformed into data models for storing into a memory, the occupied amount of the memory will be greatly increased with the increase of the size of the profiling data files. Moreover, for some huge profiling data files, it is impossible to open all these files, read all the contents thereof and then establish target data models in the memory due to the limitation of the memory capacity. In addition, in most cases, the profiling data files of the computer systems use a hierarchy of Process/Thread/Module to organize the profile data. This hierarchy reflects the structure of the systems in a runtime environment, and is very useful in most cases. However, in addition to the most useful and well-known hierarchy of Process/Thread/Module, in actual system performance analysis procedures, users often need to construct other hierarchy tree structures {which can also be referred to as perspectives} to analyze data from other different views. For example, users may want to view the usage of a certain module in different processes in a hierarchy of “Module/Process”. At this time, an additional data model for reorganizing the profiling data after recalculating all the profiling data is required. Therefore, in order to represent a plurality of hierarchy tree structures, it is required to define a plurality of hierarchies and generate different target data models, thus more memory space will be occupied. Thus, what is needed is a technique by which a predefined relational model can be established based on profiling objects and data type of profiling data in a computer system and the profiling data of the computer system can be reorganized according to different hierarchies based on the predefined relational model to generate different hierarchy tree structures. Users and system performance analyzers could freely view a target hierarchy tree structure as needed and obtain profiling information of corresponding profiling objects in the target hierarchy tree structure.
What about a Disability Rights Act for Canada?: Practices and lessons from America, Australia, and the United Kingdom. The Harper government and most national political parties are committed to a federal act for dealing with accessibility rights for persons with disabilities. The purpose of this article is to identify progressive lessons from countries with similar legislation for consideration by Canadian authorities. Countries surveyed are the United States, Australia, and the United Kingdom. While disability rights legislation is widely accepted to be a necessary policy initiative in light of ongoing barriers and exclusion, experience suggests that such laws are far from a sufficient response to promote access. Other policy instruments required include supportive employment programs, tax incentives, and the direct provision of basic supports.
Q: diffptr_t fortran with iso_c_bindings I'd like to have a kind of diffptr_t in fortran with iso_c_bindings. The memory distance result must be a signed int. type(c_ptr) :: start,ref type(c_int) :: res start=c_loc(my_struct%a) ref=c_loc(my_struct%b%c) res=start-ref Compilation error: This binary operation is invalid for this data type. An arithmetic or LOGICAL type is required in this context. Thanks A: You cannot do pointer arithmetic in standard Fortran. You have to rely on the processor dependent binary correspondence between pointers and integers. Also, there are no unsigned integers in Fortran. type(c_ptr) :: start,ref integer(c_int) :: res start = c_loc(my_struct%a) ref = c_loc(my_struct%b%c) res = int( transfer(start, 1_c_intptr_t) - transfer(ref, 1_c_intptr_t) , c_int) There may be problems, if the pointer values are larger, than the maximum positive value for the signed c_intptr_t.
export function writeToClipboard (str) { var textarea = document.createElement('textarea') textarea.textContent = str document.body.appendChild(textarea) textarea.select() document.execCommand('copy') document.body.removeChild(textarea) }
Conservative Management of Neuropathic Pain in a Patient With Pancoast-Tobias Syndrome: A Case Report. Pancoast-Tobias syndrome characterizes the signs and symptoms of a superior pulmonary sulcus tumor, and includes arm and shoulder pain, atrophy of intrinsic hand muscles, and ipsilateral Horner syndrome. The rarity and overall poor prognosis of patients with superior pulmonary sulcus tumors associated with Pancoast-Tobias syndrome has led to few reports detailing pain management strategies with adjunctive therapies, such as continuous infusions of ketamine and lidocaine, chemotherapy, radiation, and multimodal oral medication regimens. This case highlights the diagnosis and treatment of pain in a patient with Pancoast-Tobias syndrome.
The following description is provided to assist the understanding of the reader. None of the information provided or references cited is admitted to be prior art. Vitiligo is a pigmentation disorder in which melanocytes, the cells responsible for skin pigmentation, are destroyed. As a result, white patches appear on the skin in different parts of the body. Although patches are initially small, they often enlarge and change shape. Vitiligo lesions can appear anywhere, but are most commonly found on the acral areas, mucous membranes (tissues that line the inside of the mouth and nose), retina and genitals. Other symptoms include increased photosensitivity, decreased contact sensitivity response to dinitrochlorobenzene, and premature whitening or graying of hair that grows on areas affected by vitiligo. A Black light can be used in the early phase of this disease for identification and to determine effectiveness of treatment. Skin with vitiligo, when exposed to a Black light, will glow yellow, green or blue, in contrast to healthy skin which will have no reaction. A number of medical therapies including topical steroid therapy, psoralen photochemotherapy, and depigmentation can reduce the appearance of vitiligo. However, each of these therapies is associated with drawbacks in efficacy and/or severe side effects such as skin shrinkage, severe sunburn, blistering, hyperpigmentation, cataracts, inflammation, nausea, vomiting, itching, abnormal hair growth, and skin cancer. Furthermore, surgical therapies are not optimal because they are only appropriate for a subset of vitiligo patients and are accompanied by the risk of infection, scarring, blistering, and abnormal pigmentation. Thus the need for therapeutic strategies that effectively and safely combat vitiligo still remains.
Molecular and cellular mechanisms of cadmium carcinogenesis. Cadmium is a heavy metal, which is widely used in industry, affecting human health through occupational and environmental exposure. In mammals, it exerts multiple toxic effects and has been classified as a human carcinogen by the International Agency for Research on Cancer. Cadmium affects cell proliferation, differentiation, apoptosis and other cellular activities. Cd2+ does not catalyze Fenton-type reactions because it does not accept or donate electrons under physiological conditions, and it is only weakly genotoxic. Hence, indirect mechanisms are implicated in the carcinogenicity of cadmium. In this review multiple mechanisms are discussed, such as modulation of gene expression and signal transduction, interference with enzymes of the cellular antioxidant system and generation of reactive oxygen species (ROS), inhibition of DNA repair and DNA methylation, role in apoptosis and disruption of E-cadherin-mediated cell-cell adhesion. Cadmium affects both gene transcription and translation. The major mechanisms of gene induction by cadmium known so far are modulation of cellular signal transduction pathways by enhancement of protein phosphorylation and activation of transcription and translation factors. Cadmium interferes with antioxidant defense mechanisms and stimulates the production of reactive oxygen species, which may act as signaling molecules in the induction of gene expression and apoptosis. The inhibition of DNA repair processes by cadmium represents a mechanism by which cadmium enhances the genotoxicity of other agents and may contribute to the tumor initiation by this metal. The disruption of E-cadherin-mediated cell-cell adhesion by cadmium probably further stimulates the development of tumors. It becomes clear that there exist multiple mechanisms which contribute to the carcinogenicity of cadmium, although the relative weights of these contributions are difficult to estimate.
Q: Trouble performing simple GET request returning JSON with Javascript I'm horrible at Javascript, so sorry in advance for what I'm going to go ahead and assume is an amazingly stupid question. I'm simply trying to perform a GET request to GitHub's public repo API for a given user, and return the value as JSON. Here's the function I'm trying to use: function get_github_public_repos(username) { var the_url = "http://github.com/api/v2/json/repos/show/" + username $.ajax({ url: the_url, dataType: 'json', type: 'get', success: function(data) { alert('raw data: ' + data) var json_response = $.parseJSON(data); alert(json_response); } }); } This is returning Null for data. And in the console, I see Failed to load resource: cancelled. I know the URL is correct, because if I run curl on the url, it returns the expected data. A: jQuery's ajax function supports JSONP which allows cross-domain requests (which you need because you're trying to request data from github.com from another domain). Just change the dataType from 'json' to 'jsonp'; function get_github_public_repos(username) { var the_url = "http://github.com/api/v2/json/repos/show/" + username $.ajax({ url: the_url, dataType: 'jsonp', type: 'get', success: function(data) { var json_response = data; alert(data); } }); } UPDATE: It's import to note that the end pint (in this case github.com's API) has to support JSONP for this to work. It's not a guarnateed solution for ANY cross-domain request as pointed out in the comments.
Are those that eat meat and are aware of the arguments for vegetarianism bad people? I am currently eating a steak. It came from a dead animal - one who most likely didn't have the greatest life, one could say suffered - One could go so far as to say the animal I am eating used to live a life of torture. I am perfectly well aware of the arguments for not eating meat. The arguments against animal abuse. I have watched the videos of animals being slaughtered because I wanted information to make an informed opinion. It wouldn't be a lie for me to admit that I agree with all the arguments from the non meat eater/vegetarian crowd. I agree with them almost completely. That the animals do in fact suffer more than they should. But honestly - eating this steak makes me feel good. I enjoy chewing it, tasting it - the red and bloody steak it becomes with butter and pepper. It's delicious to me. I guess it's more that I just don't care about the suffering the animals enough for me to give up my delicious steak. Or veal chop. Or rack of lamb. What say you, rational minds? Am I a 'bad person' for admitting that the arguments make sense and yet I choose to simply ignore them for my own one could say - selfish and short-term desires? Replies to This Discussion The arguments you are responding to are purely emotional ones, not intellectual ones. This is a form of propaganda manipulating you through your sense of empathy. The fact that you enjoy eating meat does not make you a "bad person". You are a human being. Human beings are omnivorous animals and omnivorous animals eat meat. Meat eating animals aren't "bad" because they desire to eat meat. What you are calling "arguments that makes sense" are simply emotional appeals - they "feel" correct. This is a tactic of theists to "prove" the exist of their pet deity/deities. And they are attacking you by triggering feelings of self-hatred (guilt). In short they are manipulating you into attacking yourself. Don't feel guilty - get angry! These people who did this too you are abusing you and what they did was no less worse than what you saw being done to other animals in those videos; in fact it may be even more so (subjectively). The answer to that question is deciedly NO. You have a perfect right to eat meat. I've met some vegetarians who did not like hearing about meat eating per se. After giving her comments, my brother mentioned that he had recently returned from a black powder hunt with a wild boar. He went into great detail. At the time, he needed the meat to survive. This happened at a New Year's eve party. Though my brother did not intend to gross her out, he had a right to speak and follow his own precepts. The young lady did appear a bit affected, but not horribly so. If by bad, you mean doing something that you know you shouldn't, then yes, you're bad. The tension between doing the right thing and making yourself happy is less easily resolved by atheists. Like the vast majority, you set aside what you know to be wrong to satiate selfish desires. The question in the title makes the assumption that if you are "aware" of the arguments, you will necessarily be compelled to agree with them, and that the ONLY reason you won't then become a vegan is because you are bad. It leaves no room for the possibility that you might disagree with the argument. Pretty arrogant. Here, try this one, same tactic. "You've heard my arguments for Jesus, so since you aren't a Christian you deserve to go to Hell."
Description This dark copper blonde 'do is worn over one shoulder showing off the soft waves added to the mid-lengths to ends for shape and style. The long bangs are smoothed down to frame the sides of the face and completes the over-all look perfectly.
Q: Why didn't he get the power of Mjolnir? In Avengers: Age of Ultron, Vision picked up Mjolnir very easily, making him worthy but why didn't he get Thor's power? In the comics, whoever holds Mjolnir, gets the power of Thor, too. Why doesn't it happen in the movie? A: Let me counter this with another question (and an admittedly slightly speculative answer): What makes you think Vision didn't get the power of Thor at all? In the movie we see Vision actively wield Mjölnir, not only when he hands it to Thor, he also uses it in combat. So he definitely can wield the hammer and make use of its power. The question remains then, what you define as "the power of Thor" then (and how much of that is actually related to the hammer directly or more to Thor). Is it the lightnings? We don't see him use them but he might just not have made use of them in the few times he wielded the hammer. Is it the strength and invulnerability? Well, Vision had that already anyway, given his perfect bio-mechanical bodily form. Or is it the ability to rule over Asgard? I would say Vision is actually worthy of that, too. As described in my answer to another highly related question Vision is actually worthy of the hammer and scenes with him carrying the hammer a supposed to convey exactly that: Vision seems to be the embodiment of the ancient ideal of a perfect mind in a perfect body, one that combines the advantages of a mechanical intelligence with the concerns and soul of an organic lifeform and brings compassion for his (undoubtedly inferior) human fellows, in contrast to his purely mechanical brother Ultron. He thus seems to be the ideal creation of a humanity that strives for posthuman evolution. One could say in his second try Tony Stark (with the help of an actual (demi)god and some magic alien artifacts, though) overcame his role as merely a "Modern Prometheus" and didn't just create sentient life, but a new god in itself. And the fact that Vision is able to wield Mjölnir to me doesn't come from the fact that he is "just a machine", as Tony and Steve argue jokingly at the end, but from the fact that he is superior to us all not only in his body but even more so in his mind. And this I think is the attitude that Mjölnir is attracted to, as already shown in the first Thor movie and also in this one when Steve nearly achieves to lift it (which was not because he is the strongest, but because he is the noblest at heart). In fact, Tony's and Steve's theories about Vision being "only a machine" at the end even support the interpretation that this is not the case by the mere humorous way they are presented in. Of course their childish excuses are not the reason for why The Vision achieved what they couldn't. In fact his pickung up the hammer is a perfect and to the point illustration of Vision's superiority and immediately clarifies that to the viewers, a symbol that has been explicitly set up by the earlier scene (with the whole gang trying to pick up the hammer) for exactly that purpose. So yes, Vision does get the power of Mjölnir and Thor with everything connected, including the abstract notion of "being worthy". But what makes Vision so extraordinary as part of his "worthiness" and what makes this worthiness and power seem so trivial (without the nice effects described in the other answer) is that he doesn't strive for this, he doesn't care to rule over Asgard, not because he can't as "a machine" or because he doesn't have a soul, but because his mind and motivations are above such "worldly" considerations. His light-handed and downplayed way to hand over the hammer to Thor and his easy ability to carry it in battle convey both his worthiness and his not caring about this at all. He is a god without a god-complex. So I'd wonder if there's anything else that defines "the power of Thor" and that Vision lacked or didn't demonstrate. The fact that we don't see him use all of Thor's powers to the fullest might just be due to the fact that Vision doesn't need to use them, he has his own powers (which aren't inferior to Thor's at all). And using Thor's or Mjölnir's powers above being necessary is not in his nature, as explained. A: As Steve and Tony try to comfort Thor at the end of Avengers: Age of Ultron, they mention that an elevator can lift Mjolnir, but an elevator is not worthy. We see this example in action in both The Avengers (when the Helicarrier is capable of lifting Mjolnir) and Thor: The Dark World (when a coat hanger is capable of lifting Mjolnir), so we know that it has at least some basis in the reality of the Marvel Cinematic Universe. It would seem that as The Vision is an android, he is exempt from the rules of Mjolnir, meaning that he can lift it, but he is not granted the power of Thor. As I have said in this answer, when we do see The Vision use Mjolnir rather than simply holding it (when he hits Ultron with it), we see that he hits no harder when 'wielding' Mjolnir than he would have anyway. Additionally, when we see Thor regain his worthiness in Thor, his lifting of Mjolnir is accompanied by various special effects indicating him being 'powered up', none of which are present when The Vision lifts Mjolnir - because he isn't worthy, and has not been granted the power of Thor. In short, The Vision can only lift Mjolnir because his status as an android would seem to make him exempt from the rules, meaning that he is not granted the power of Thor.
Primordial rare gases in unequilibrated ordinary chondrites. The primordial gases of eight unequilibrated ordinary chondrites are strongly fractionated with respect to" cosmic" proportions. The absolute amounts are roughly proportional to the degree of disequilibration. Apparently, ordinary chondrites originally contained considerably larger amounts of primordial rare gases.
Wanted to know what kind of questions the insurance agent asks you when applying for workmans comp. Do they ask any questions specifically about your employees? Or just how much you pay them? I have a guy that I am ready to hire who is legal and one guy who is not legal yet. Will the agent ask me specific questions about my employees or just general questions about about he payroll?
Q: Releasing UIViewController when its view is removed via removeFromSuperview I have a main view that manually creates a UIViewController (not a UINavigationController) and adds that controller's view as a subview. The subview then dismisses itself via [self removeFromSuperview]. I understand this releases the view, so that is good, however I now want to get also get rid of the UIViewController I alloc'ed immediately when the view is removed to free up memory and not wait until the main view controller is dealloc'ed. I could avoid using removeFromSuperview and have a backreference to the main view controller and get it to dismiss the subview and release the controller, but it feels like there should be a cleaner way. Is there an established best practice for accomplishing this? A: The correct way is for your subcontroller to ask the main controller to remove it. If you want to reduce the coupling between the two controllers, create a delegate protocol for your subcontroller: // This forward declaration avoids having a circular dependency // between MySubcontroller and MySubcontrollerDelegate @class MySubcontroller; @protocol MySubcontrollerDelegate - (void)hideMySubcontroller:(MySubcontroller*)subcontroller; @end If there is other information that the subcontroller needs to communicate to the supercontroller, this is a great place to add relevant calls. You might not need to do so right away, but keep it in mind for future versions of your app. Then add a delegate property to the subcontroller: @interface MySubcontroller : UIViewController { id <MySubcontrollerDelegate> delegate; ... } @property (assign) id <MySubcontrollerDelegate> delegate; ... @end Instead of calling removeFromSuperview on its view, the subcontroller should call hideMySubcontroller: on its delegate, passing self as the argument. Your main controller should then declare that it implements the delegate protocol: @interface MyMainController : UIViewController <MySubcontrollerDelegate> ... @end When the main controller creates a subcontroller, it should set the subcontroller's delegate property to self. It should implement a hideMySubcontroller: method which removes the subcontroller's view, deallocates the subcontroller, and does whatever else is needed. Using a delegate protocol means that the subcontroller doesn't have to have any knowledge of what kind of object will use it; it just knows that there is such an object somewhere and that it will conform to the delegate protocol. Thus, the coupling between the two controllers is kept as small as possible. By the way, if you can manage it, it's actually better to keep the subcontroller around in case you need to use it again; that'll save the processing time it would take to recreate it. (However, you should release it if you receive a memory warning.)
import re from .settings import Settings class _RE: """ Regular Expressions wrapper """ @classmethod def instance(cls): if not hasattr(cls, "_instance"): cls._instance = cls() return cls._instance def __init__(self): self.patterns = {} def get(self, pattern_key, pattern=None): """ Returns a compiled regular expression pattern, if not compiled, otherwise, a cached pattern @param pattern_key: a regular expression pattern key to search in the settings @param pattern: a regular expression pattern if provided, will be used as a pattern instead of searching from settings """ if pattern_key not in RE().patterns: pattern = pattern or Settings().get(pattern_key, default=None) if pattern is None: return None RE().patterns[pattern_key] = re.compile(pattern) return RE().patterns[pattern_key] def search(self, pattern_key, *args): """ Returns a pattern searched result @param pattern_key: regular expression pattern key to search in the settings @param args: overloading arguments for a search function """ pattern = RE().get(pattern_key) if pattern is None: return None return pattern.search(*args) def match(self, pattern_key, *args): """ Returns a pattern matched result @param pattern_key: regular expression pattern key to match in the settings @param args: overloading arguments for a match function """ pattern = RE().get(pattern_key) if pattern is None: return None return pattern.match(*args) def sub(self, pattern_key, *args): """ Returns a pattern substituted result @param pattern_key: regular expression pattern key to substitute in the settings @param args: overloading arguments for a substitute function """ pattern = RE().get(pattern_key) if pattern is None: return None return pattern.sub(*args) def RE(): return _RE.instance()
Morphological and Molecular Defects in Human Three-Dimensional Retinal Organoid Model of X-Linked Juvenile Retinoschisis. X-linked juvenile retinoschisis (XLRS), linked to mutations in the RS1 gene, is a degenerative retinopathy with a retinal splitting phenotype. We generated human induced pluripotent stem cells (hiPSCs) from patients to study XLRS in a 3D retinal organoid in vitro differentiation system. This model recapitulates key features of XLRS including retinal splitting, defective retinoschisin production, outer-segment defects, abnormal paxillin turnover, and impaired ER-Golgi transportation. RS1 mutation also affects the development of photoreceptor sensory cilia and results in altered expression of other retinopathy-associated genes. CRISPR/Cas9 correction of the disease-associated C625T mutation normalizes the splitting phenotype, outer-segment defects, paxillin dynamics, ciliary marker expression, and transcriptome profiles. Likewise, mutating RS1 in control hiPSCs produces the disease-associated phenotypes. Finally, we show that the C625T mutation can be repaired precisely and efficiently using a base-editing approach. Taken together, our data establish 3D organoids as a valid disease model.
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<!DOCTYPE html> <html> <head> <title>Example: h5.storage</title> </head> <body> <h1>Example: h5.storage</h1> <script src="core.h5ive.js"></script> <script src="storage.h5ive.js"></script> <script src="example-storage.js"></script> </body> </html>
[Infantile brucellosis (author's transl)]. Some aspects concerning brucellosis are revised. This is a disease with a high incidental rate among the children's population in Salamanca and bordering provinces. The local prevailing epidemiologic conditions are reviewed, as well as the most outstanding clinical features, which are in children, according to the author's personal experience, less protean than in adult's illness.
Haven't seen this response yet, so here's what I do: cardboard (big sheets from refrigerator boxes and such that I get free from the local True Vaule store) but instead of one layer, I put down two. That way, when the top layer gets so nasty I can't stand it any more (or when it starts wearing through, like somebody said earlier,) I can just take up that layer and still have another layer left to finish the season with. The double layer also adds quite a bit of welcome cushioning for old tired feet on my concrete floor.
[Multiple cerebral infarction during anesthesia in a patient with hypergammaglobulinemia]. We experienced anesthetic management of two patients with hypergammaglobulinemia undergoing thoracoscopic lung biopsy, one of whom suffered from multiple cerebral infarction during anesthesia. Pathogenesis of this serious complication could not be elucidated. However, decrease in cerebral regional circulation caused by increase in blood viscosity would be most probable. We should preoperatively carry out measurement of blood viscosity and brain CT scan, and consider plasma exchange in patient with hypergammaglobulinemia, in whom symptoms and signs of hyperviscosity syndrome do not exist.
I. Field of the Invention The present invention relates generally to the game of golf and, more particularly, to a device for setting a player's stance. II. Description of the Prior Art In the game of golf the player stance, i.e. the position of the player's feet with respect to the golf ball, is of the utmost importance in order to obtain a good golf shot. If the player's feet are improperly positioned when he or she addresses the ball, hooks, slices and other poor shots frequently result. The proper stance for a player varies from one player and to the next. Furthermore, the proper stance also varies depending on the type of shot to be made. For example, a proper stance for a tee shot for a player will be different than the proper stance for a nine-iron shot even for the same player. Most players determine their proper golf stance for the various different golf shots only through practice and experience. However, even experienced golfers adopt improper golf stances after periods of golf inactivity. When this occurs, it often takes the golfer several rounds before he or she regains their proper golf stance.
Q: Image Gallery tie in with database? I'm developing an image gallery for one of my customers, they want a very minimal, simple and easy user experience. The image gallery must contain a title and description of each image, we have created a app to upload the images and set titles and descriptions this is stored in a mySQL database. We're developing this site with php. Before I go off and develop this, does anyone know of any opensource galleries that tie into a mySQL database with similar functionality? Or maybe this approach is naive? Maybe I should approach this from a different direction and not use a mySQL backend.. Any advice is very welcome. Josh A: This one looks decent: http://gallery.menalto.com/. It supports MySQL and a bunch of other DBs. For something this simple, you could get by without a database (however I doubt you would be able to have a title and description for the images without using a flat-file database; not recommended). To do it without a database, try this: http://spgm.sourceforge.net/. However, if you already have written the uploader which works with MySQL, I would go with the database option and tweak it if necessary to work with the first link I posted.
"Gov. Lujan Grisham continues her piecemeal solution to our serious problem of treating constituents fairly. We've now learned it will be at least June before dine-in restaurants, salons, gyms and other establishments can be considered for a partial reopening. The continued shutdown is killing livelihoods while other businesses are partially opened and national chains take in New Mexico dollars. This is unjust and unfair. The inequitable order is forcing hundreds of restaurants to close, bankrupting other establishments and collapsing our state's economy."
A quiet killer is looking for a room. The real state agent, shy and expressionless, guides him through all the rooms she can find in Tokyo, but none of these satisfy the killer’s request for peace and silence. The real state agent, without any emotion, leads the poetic, soft-spoken killer towards the ruined districts the decadent economy left behind in the outskirts of Tokyo, in hopes of finding The Room.
Q: Set HTML using JQuery I try to change HTML using JQuery jQuery("#message").html() = "Done"; but the console complains "Uncaught ReferenceError: Invalid left-hand side in assignment" How can I make it valid? A: Close, you want jQuery("#message").html("Done"); A: It is $('#message').html('Done'); A: jQuery("#message").html("Done"); Please read documentation you will feel better, at least your code...
About Me Projects My own Short Shorts In my teens a wrote a few pieces, one of which somehow survived - and so, like it or not, here it is. The Trumpeter I have no idea where the inspiration for this very short piece came from, but re-reading it now I'm surprised by it. And really rather pleased with it. As the last echoes of the long, lingering note faded away, the silence welling up in the cramped and untidy room, the trumpeter took the instrument from his lips. Once a thing of shining brass and silver, the years had taken their toll on the neat curves and the delicately sculpted horn. Once an object of great value, the battered trumpet bore testament to its years of faithful service. The man held the trumpet like it was a baby, his eyes seeing not the worn brass but another, brighter thing. It was a cherished child, a faithful friend, not a possession but a part of him. Perhaps the most important part. Without it he was a silent, grim old man too old to be loved by strangers, too much of a stranger to be loved by family. He had made his choice. The music was his life, and his family, and he was not unhappy that he had grown old in the company of his oldest, dearest friend. Raising the instrument to his lips once more, the room came alive again with the sounds of the laughter they created together. Not music. More than music. It was as if the magic of life was being set free from it's mortal shell and allowed to roam wild within the confines of the room. Only the walls were present for the performance, only the walls which had been the audience of many private performances in the previous months. Years. Was it decades? It seemed forever. The wallpaper clung patchily to the walls, as if possessing the will to fight the years of neglect, and damp, and cold. A stained carpet, barely managing to hide the floor in the doorway and at the foot of the old man's chair, did its best to present the man it served with comfort; but failed. Through the open doorway, a tiny kitchen glared out at the sounds of life - furious that the music was forever just beyond its grasp, bouncing off the walls and returning to die at the feet of its master. Man and trumpet seemed somehow younger when joined in the passion of their effort. No, not younger, but wiser, more peaceful. Less worn by time, worry, the effort of clinging to existence these past years. Clinging to life when life wanted to leave, to be free. But right now the life was flowing again, through man and trumpet and breathing its magic into the air itself. Charging the atmosphere to the point of bursting as the music reached a crescendo, splitting the peace of the relaxed rhythm with a piercing, strident note which created waves upon waves upon waves... Then falling, losing the life, the lustre. Deepening to a ruby red sheet of pain which made the walls wince in the agony of it. And then it was all over. The music was lost forever. The room settled down to mourn the loss of a dear friend.
There has heretofore been provided a wide variety of construction elements that are readily assembled together to make up a variety of structures of different geometric configurations. Some construction elements have what is basically a ball and socket joint with snap-fit connections and others utilize what are basically rods or rods and cylinders that telescope one within another. In sets of these construction elements it is a frequent practice to have a number of differently shaped elements. While known prior art units are to some extent satisfactory, the present invention is believed to provide a number of advantages over known prior art. Accordingly, it is an object of the present invention to provide a basic construction element that is simple, durable, attractive, and highly versatile. Another object of the present invention is to provide a construction element that has wide versatility and flexibility in the manner of its assembly and interfitting with identical elements to make up a large number of variations of assembled structures. Yet another object of the present invention is to provide a construction element that may be made of any required size but with selected dimensional and angle relationships and take the form of a solid block, hollowed block, or of strip material body and made of metal, wood, plastic or other suitable material. Still a further object of the present invention is to provide a construction element characterized by having the external shape essentially that of a double triangle with the two triangles integrally connected at a tapered, cut-off projection of each to provide four tapered projections and a tapered recess with particular dimensional proportions and particular angular relationships that make the construction elements suitable for being made at about any scale for toy building blocks as well as larger sizes for building structures.
Q: What are all the ways to check if a file exists in ruby without shelling out? What are all the ways to check if a file exists using Ruby's core classes/modules without shelling out? Would also appreciate reasons why choosing one method over another makes sense. For example: Using Dir['**/*'].grep(/foo/) is the shortest way I've found to match paths using a regex. However, I think Pathname.new('.').find.any? { |pn| pn.fnmatch? "*foo*" } is a good option because Pathname is a cross-platform solution that usually seems to "just work". Are there any solutions/classes/modules I've missed? Also, would appreciate answers that involve speed/efficiency analysis. require 'minitest/autorun' require 'pathname' class TestTouch < Minitest::Test include FileUtils attr_reader :foo def setup @foo = Pathname.new('foo') foo.delete if foo.exist? end def teardown foo.delete if foo.exist? end def test_touch touch foo cwd = Pathname.new('.') assert cwd.find.to_a.map(&:to_s).grep(/foo/).any? assert cwd.find.any? { |pn| pn.fnmatch? "*foo*" } assert cwd.join('foo').exist? assert Dir['**/*'].grep(/foo/) assert Dir.glob('**/*').grep(/foo/) assert !Dir.glob('foo').empty? assert File.exist?('foo') end end A: Off the top of my head... Pathname.exist?(NAME) FileTest.exist?(NAME) Pathname.file?(NAME) FileTest.file?(NAME)
Q: How C++ Libraries like POCO can have access to network? How C++ libraries like POCO can have access to the computer's network and can do networking tasks? Does POCO use OS's APIs to access network or it use hardware directly to access to network? A: On modern operating systems such as Linux/Unix or Windows, applications (and libraries) don't have direct access to hardware. To access network connections, the OS provides APIs like the BSD Sockets API (Linux Manpage) and the Windows adaptation WinSock. Libraries like POCO just provide convenience wrappers around those, possibly adding High-Level protocols like HTTP.
It has got a light smell of tea tree, which i do not like, but it is so inessential that doesn't bother at all. Leaves my skin soft and clean. You can leave it on your face for a couple of minutes to get more exfoliating effect.
.nav_links -# Recent Activity .el= link_to t('.recent_activity'), root_path, :class => 'recent_activity' -# All Projects .el#my_projects = link_to t('.all_projects'), projects_path, :class => 'home' %span - .contained#my_projects_list -# My Tasks - near_tasks = current_user.nearest_pending_tasks - today_tasks = near_tasks.select { |t| t.urgent? || (t.due_on && (t.due_on <= Time.now.to_date)) } - late_tasks = near_tasks.select { |t| t.due_on && (t.due_on < Time.now.to_date) } - pending_tasks = near_tasks - today_tasks - if today_tasks.any? .el#today_tasks{ :class => late_tasks.any? ? 'late_tasks' : '' } = link_to t('.today'), task_lists_path, :class => 'today' %span= today_tasks.length .contained - for task in today_tasks.reverse .el.task{ :id => "my_task_#{task.id}", :class => task_classes(task) } = link_to task, [task.project, task], :class => '' = render_due_on(task,current_user) .el#my_tasks = link_to t('.my_tasks'), task_lists_path, :class => 'tasks' %span.clickable= link_to pending_tasks.length, task_lists_path(:filter_assigned => 'mine'), :class => 'hoverable', :'data-hoverable-class' => 'left', :id => 'open_my_tasks', :title => t('.open_my_tasks') .contained - for task in pending_tasks .el.task{ :id => "my_task_#{task.id}", :class => task_classes(task) } = link_to task, [task.project, task], :class => '' = render_due_on(task,current_user) .el= link_to t('.show_all_tasks'), task_lists_path, :class => 'more' .el= link_to t('.gantt_and_calendars'), gantt_view_task_lists_path, :class => 'more' -# Organizations .el#my_organizations= link_to t('.organizations'), organizations_path, :class => 'people' .contained#my_organizations_list -# More options .el.extra= link_to t('.time'), time_path, :class => 'ajax time'
module Workarea class IndexAdminSearch include Sidekiq::Worker include Sidekiq::CallbacksWorker sidekiq_options( queue: 'low', lock: :until_executing, query_cache: true, enqueue_on: { ApplicationDocument => [:save, :touch, :destroy], with: -> { [self.class.name, id] }, ignore_if: -> { !IndexAdminSearch.should_enqueue?(self) } } ) def self.should_enqueue?(model) search_model = Search::Admin.for(model) search_model.present? && search_model.should_be_indexed? end def self.perform(model) search_model = Search::Admin.for(model) return false if search_model.blank? if model.persisted? && search_model.should_be_indexed? # For the admin, we don't want to index release changes Release.with_current(nil) { model.reload } if Release.current.present? search_model.save else search_model.try(:destroy) rescue nil # It's OK if it doesn't exist end end def perform(class_name, id) model = class_name.constantize.find_or_initialize_by(id: id) self.class.perform(model) end end end