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Dreams That End With a Gunshot to the Head From time to time, I wake in my bed after visiting someone else’s life, in a place so real you could touch it. I stumble through a doorway and find people I know and love, only I forgot that I’d forgotten them. It is a vision that beckons, shimmers, then slams the door in my face. As my bedroom comes back into focus, I have this sense of being stretched like a strand of hot glass, suspended between two dimensions. For a languid moment, the streets in this other world are more real than the ones I live on now. Their names are on the tip of my tongue, the contours of the hills in the distance are so familiar I must have walked them my whole life. There is a person there, waiting. But the connection cools and snaps, and the faces freeze and vanish. These places are not always easy to visit. Even when the scenery is bucolic, there is almost always an undertone of war. Most times, the only way I can escape is by accepting my own death. Sometimes death doesn’t come as needed, and I have to put a gun to my head. Sometimes I wake with relief, sometimes loss, but always with the ache of loneliness that comes with amnesia, with questions that are not meant to be answered. Last night I visited Europe during the occupation. I guess. I don’t have the words for where I was. I wore a long skirt, with an old gun hidden in my coat. My life was all about my people. I had people. I don’t know what the hell that means because I have nothing like that in this life, I have no people. But there I was surrounded by brothers, cousins, extended family all around. Our hair was dark, our skin was white, the men wore undershirts and dark pants all the same shade of beige, gray, black. I walked through the dim city streets, grit crackling under my boots, sooty fire escapes overhead, fear in my heart. Still, I wanted to fight, like an alley cat that bristles and hisses before the miscreants stone it to death. I wanted to fight because it was my in my blood, and because pride helped obscure the reality of my inevitable doom. My boys, my young men who were as close as brothers, all around me. We whispered as we passed each other. Tonight, I said. Tonight, they nodded back, as if our every move was being watched. There was this calculated façade of calm, as if we all knew what was coming: a chance. We collected in the street as if for some harmless family gathering, sitting at makeshift benches to eat and talk. There were at least a hundred of us, and we didn’t want to raise suspicion. Our small cache of artillery was hidden. The air was prickling, men with urgency in their dark eyes. This street where we sat was an alley between two factory buildings, and at each end was a tall iron fence. To protect us, perhaps, or confine us. Three lanky teenage boys wearing coats that were too small, stood at one end of the alley. They were dark-skinned with smooth black hair. Their nationality was different. They had rifles strapped on their backs, as if they were keeping watch on our behalf. They were friends of my son. A friendship, I suspected, that was ill-advised. I knew they would betray us, or we would betray them. I wouldn’t let my son go to them, and this upset him. But there was no time to sort it out. My son was lost in the crowd as it scattered. Someone was coming. Something had gone wrong. The fight was breaking out too soon. This was not as planned. Our men had been spooked. For a moment everything paused, like the silence before a falling glass shatters on the concrete, and then a single shout splintered the street into chaos. Gunfire pulverized the brick over my head. We were discovered. Now the enemy would close in from both sides and kill us all. All was lost, and so quickly. I ducked for cover in one of the buildings, doom and grief in my heart. I knew, I knew there was no way out of this. Nowhere to go. In here, the booming gunfire was muffled, but soon they would hunt me down. Death was coming for me, breathing down my shoulder, how would I meet it? Down one of the corridors stood a beautiful woman, sheltering some children. I knew her. In a world of sepia-toned shadows, her face glowed brilliantly with calm and sweetness. She had long curly hair down to her shoulders. Stay and fight, she implored me. Face the enemy and remember our cause. But I was panicked to my core, I didn’t care about our cause, I wanted only to stay alive, to find a place to hide, to escape. They’re coming! I hissed at her, climbing up to a bank of windows that lead to the roof. I rammed my shoulder into the glass, breaking a few panes, stumbling out into the air above the crossfire. The city around me was engulfed in flames. I turned to my right, but the beautiful woman had followed. She was beside me. Stop, she warned me, holding up her hand. She had seen something. A thick gunshot rang out from across the street, and a shell rocketed toward her in slow motion, leaving behind a trail of fire as it landed in her body, embedding in her coat, knocking her off the roof. I covered my eyes but I had already heard it, the soft thud that snuffed out her life. The sucking sound of her dying breath roared in my ears, louder than the deafening artillery fire, filling me with dread and sickness. Just like that, she was gone. A soldier was coming through the window behind me. I fell down to play dead, but it was too late. Before I could surrender to him, I remembered I could escape. I placed my hidden gun to my head and pulled the trigger. I’ve done this in dreams a dozen times before. First comes the loss of breath, then the darkness, the wrenching away, then the blissful fall through the escape hatch, back into my room. And then there is light. In the distance, no gunfire, just the steady hum of a leaf blower. I lay there blinking in the sunlight, breathless. When I die, will this life become as distant to me as that one, just some passing, transient dream? Will I doubt I was even here, the same way I doubt if I was there? I guess it doesn’t matter. Life on earth is fucking barbaric. Centuries of war, suffering, murder, loss– it’s in our blood, the DNA of every cell. Maybe I have a frayed strand in my heart that wicks up these memories, and when I wake it casts a little flicker, and in that brief moment before the darkness recedes, I can hold vigil between two worlds, remembering enough for everyone. Or maybe for no one.
When a mobile device stays in a location serviced by multiple access points, the mobile device may continually handoff between different access points. Frequent handoffs are caused when the signal strengths from multiple access points vary above and below a handoff signal strength threshold even when a mobile device is stationary within a location. Handoffs are designed to seamlessly switch communications from one access point to another. However, when a mobile device hands off too frequently between multiple access points, undesirable behavior may arise. Some examples of undesirable behavior are missed calls, dropped calls, and slower data rates. Additionally, some access points may not be capable of accepting incoming handoffs.
Q: Moving an Alcatel I-211M-L using Fiberoptic connection I have an Alcatal I-211M-L that I'd like to move. Is it possible to buy fiberoptic couplers and cables to extend the range of the fiberoptic cable, or do I need to call Verizon to have them move it? What should I buy, if so? Thanks! Specifically, would the coupling and cables I need be multi-mode, and if so, what size? I'm sure the connector is an SC connector on the ONT. A: It looks like it uses a normal SC/APC connector, so something like this should be working; WAN uses single mode almost exlusively, a green connector indicates Angled Physical Contact which is used with SMF only.
A quaint powder room made better use of the small space and was a convenient addition to the home's makeover. Because the Shatners try to reuse materials whenever possible, the home's old entry doors now serve as the powder room doors.
Pharmacologic treatment of attention-deficit hyperactivity disorder. Attention-deficit hyperactivity disorder (ADHD) is highly prevalent in children and adolescents. Highly effective pharmacological treatments are available that allow the child and the adolescent to function at his/her full potential. Various preparations of methylphenidate and amphetamines have been used for a long time in the treatment of ADHD. This article reviews these and some of the newer drugs used in the treatment of ADHD, including atomoxetine and bupropion.
Indigenous chicken production in Kenya: II. Prospects for research and development Poultry production and in particular indigenous chicken (IC) production has been recognised as an avenue to improve livelihoods of the rural households. Previous attempts to improve their productivity have had little success due to, among others, lack of a holistic approach in solving the constraints and dissemination of inappropriate technologies given the production circumstances and market dynamics. Marketing as a constraint is often blamed for the failure of interventions to improve livelihoods, despite lack of saturation for IC products at local and national levels and the increasing demand for the same. This paper highlights the past improvement attempts and suggests strategies to improve IC productivity and thereby improve the livelihood of the rural households which are the custodians of these genetic resources. It is concluded that there is potential for improvement of IC production in Kenya given the available genetic and physical resources. However, a holistic strategy that increases productivity without increasing production costs or leading to loss of biodiversity must be developed. Such a strategy must take into account the various uses of the IC in a rural household.
Our Different Realities Reality is different for different people because we all experience life differently. Our faith, choices, desires, and longings are based on multiple parameters of individual and social existence. Human beings experience major emotions such as love, lust, anger, satisfaction, humour differently, and this has a lot to do with the major influences we have had while growing up. For example, a child that has been continuously bullied by his classmates in his school will experience self-esteem in a completely different way in comparison to the popular kid. In such scenarios, we all need to posses the skill of empathy and sympathy to understand background of diversity of thoughts and perceptions of people. We should often encourage people to practice authenticity for the collective growth of the humanity. When people are in perpetual state of identity and emotional crisis, they have a tough time expressing their thoughts and emotions. Such a sense of self-doubt leads to a feeling of alienation and isolation. In a new researched data, migrated people are more prone to depression because they have a tough time adjusting in a new way of life wherein they have to explain their worth as a foreigner to every native citizen. No religion or culture is larger than life, and instead of distinguishing people on the basis of their faith, we should rather learn to see them as people with different realities and accept them with an open mind. Our learned behaviour and constant cultural conditioning creates a psychological barrier in accepting realities that differ from ours, but with a bit of conscious effort we can shed our conditioned mind and adapt a whole new one. Shared understanding of diversity of people and their expectations from life helps us all in living a harmonious life free of discrimination and unconscious biases.
Documentation This is the main export here. We take a list of aliases for the environment and a String to parse. The return type is Right [Command] if parsing succeeded and Left (String,Bool) upon failure. The Bool is True when the error was fatal/unrecoverable.
London's Little Gardens: Geffrye Museum's Herb Garden We plonk ourselves down on a seat and within seconds, a squirrel has tightrope-walked his way along the back of the bench, perched tentatively on our shoulder and given us a good sniff, bold as you like. Deciding we're of no interest, he totters off to a nearby bin, dives in head first, and comes back with a sandwich (ham and cheese, we later discover) which he proceeds to unwrap and munch his way through. We've been to the Geffrye Museum before, but this is the first time we've acquainted ourselves with the wildlife. We're in the front garden, on Kingsland Road, an expanse of green lawn, flanked by the almshouses which form the core of the museum itself. Aged trees filter the flickering sunlight. Benches are full of office workers lunching, pensioners reading newspapers, toddlers letting off steam. A circus group is practising on the lawn, all multi-coloured hula hoops and flying streamers. But the front garden isn't what we're here to see, and we proceed round the left side of the building to the museum's lesser-known herb gardens. The first thing of note are three tombstones. They're set in a rather dark and dingy corner, a damp spot which rarely gets any sunlight. Officially, it's known as the Ironmongers' Graveyard (the museum is situated in the former Geffrye's Almshouse of the Ironmongers' Company). The remains of Sir Robert and Lady Geffrye are buried here, along with Thomas Bethon, a member of the Ironmonger's Company, and Maria Chapman, a matron of the almshouses. It's a foreboding welcome to the gardens, but do persevere. Pass the plaque marking the time capsule on your right — the time capsule itself is of course buried deep — and head deeper in. Entering the walled garden feels like a secret in itself — it's the stuff childhood dreams are made of, a black wooden door pinned back against the brickwork acting as an invite inside. The walled garden is split into quadrants, a pergola-covered bench nestled into each of the four walls. A brick pathway skirts the edge of the garden, and criss crosses the middle. The sun beats down on the trickling central fountain. The fragrant smell — jasmine? honeysuckle? — is enough to put us in mind of the countryside — excluding, of course, the Overground trains gliding past on the tracks just a few metres above. A closer look at the green floor tiles surrounding the fountain reveals dedications to the people and organisations who helped create it. Outside of the walled garden, the herbs continue. Considerable thought has gone into the garden — it's organised into time periods, as is the museum. Each plant is carefully labelled, some more alarmingly than others, and historical research has gone into getting an accurate layout for each time period. By the time we reach the late-Georgian period, the smell of freshly-baked cookies from the museum's cafe is almost too much to bear. We'll be honest; this isn't our first trip to the Geffrye Museum's gardens. The wisteria of a few weeks ago has died off, but the gardens as a whole are greener, more luscious now in May. Focus is very much on herbs and historical accuracy rather than aesthetics, so it's not London's most colourful garden — but it does get increasingly vibrant towards the far end of the brick footpaths. At the end of the path, a 'No Entry' signs appear on the gate, despite the garden seeming to continue beyond — and then we see why: The other side of the short hedge is a cluster of beehives, visible to the public but at a safe distance. It's clearly working. The whole area is a hive of activity. Bees and wasps swarm the plants, butterflies flutter by — and schoolchildren arrive en-masse at Hoxton station opposite, ready for a day at the museum. The garden's been open since the early 1990s. Prior to this, the land was derelict. A team of gardeners is hard at work today, stopping long enough to be complimented by a visitor on their efforts so far. Despite the constant arrival of trains at the station opposite, and the rumble of traffic on Kingsland Road, you could do a lot worse than spending a summer's afternoon among the herbs, bees and squirrels of the Geffrye Museum's garden.
It's not an outright ban, which is what Russia threatened Telegram with, and the size of the fine implies that Russia's doing this for show. Telegram founder Pavel Durov posted about the decision on the social networking site VK (which he also founded). He claims that the demands of the FSB, Russia's state security organization, are unconstitutional. What's more, they are not feasible from a technological standpoint. After all, providing backdoor access to an app isn't exactly a simple endeavor. Durov is currently working on appealing the decision. His VK post asks any lawyers interested in this case to contact him; they will choose from the candidates in the next few days. It's not a large fine, to be sure, so Telegram could just pay it, but it's clear that Durov wants to take a stand on the issue of user privacy.
Description: Jamal Jeffries and his trash-talking, ball-hogging, team-hating ways get him booted out of the league. When his fancy accessories--crib, cars, ultra-fine girlfriend--dribble away as quickly as his career, a desperate, financially-strapped Jamal takes his last shot at crashing the boards. Transforming himself into female power forward "Juwanna Mann," Jamal scores a tryout with the only pro organization that will take him--the women's league. It's tough enough for Jamal/Juwanna to contend with fierce competition on the court and proper protocol in the ladies' locker room, but his identity crisis hits another snag when he falls for team captain Michelle Langford. Too bad Michelle is already tight with smooth-talking lady killer Romeo, a dawg with moves sprung straight from Jamal's old bad boy playbook. And when rapper Puff Smokey Smoke tries to score with Juwanna, there are more balls in play than Jamal knows how to handle. It's gonna take more than a heavily-padded sports bra for Jamal to bounce back, but by the buzzer, he'll learn that to be a better man--and ballplayer--he's gotta get in touch with his feminine side.
Instituto Federal de Educação, Ciencia e Tecnologia de Goiás
QAIT: a quality assurance issue tracking tool to facilitate the improvement of clinical data quality. In clinical and translational research as well as clinical trial projects, clinical data collection is prone to errors such as missing data, and misinterpretation or inconsistency of the data. A good quality assurance (QA) program can resolve many such errors though this requires efficient communications between the QA staff and data collectors. Managing such communications is critical to resolving QA problems but imposes a major challenge for a project involving multiple clinical and data processing sites. We have developed a QA issue tracking (QAIT) system to support clinical data QA in the Clinical Breast Care Project (CBCP). This web-based application provides centralized management of QA issues with role-based access privileges. It has greatly facilitated the QA process and enhanced the overall quality of the CBCP clinical data. As a stand-alone system, QAIT can supplement any other clinical data management systems and can be adapted to support other projects.
The present invention relates generally to the field of protector devices that protect a phlebotomist and the like from accidental puncture by an exposed needle. Specifically, the invention relates to a needle protector having two engageable halves that enclose the needle of a catheter assembly following use of the needle in a patient. Phlebotomists represent one sector of the health care industry exposed to risks arising from accidental skin puncture by used needles. Accidental skin puncture can introduce viruses, bacteria, and other elements present in the circulatory system. An increased awareness of the hazards of skin punctures has arisen with the advent of AIDS in the health care sector, since AIDS is reportedly transmitted via the circulatory system. In normal practice, using a terminal needle a phlebotomist draws blood from an individual to deliver blood into an attached syringe, directly into sampling tubes, or via a catheter assembly to collection bags for storage and subsequent use. Once the blood is drawn and the phlebotomist removes the needle from the patient's arm, there is risk of puncture from the exposed contaminated needle. During subsequent blood sampling, a phlebotomist risks needle puncture while inserting a vacutainer on the receiving end of the same or an in-line needle assembly. A phlebotomist also risks accidental puncture while replacing the old needle cover. Exemplary art protection devices, consist of a hollow cylinder having a large top flange designed to protect the phlebotomist from impalement. The needle point is guided and inserted into a small hole in the flange and the needle hub is snapped into place. Thus positioned, that pointed end of the needle extends into the hollow cylinder. A vacutainer, or other similar sample tube, can then be inserted into the opposite end of the device so that the needle point punctures the vacutainer stopper and a blood sample drawn from the patient is directed into the vacutainer. The sampling procedure may then be repeated, replacing the vacutainer for multiple sampling, or the entire device is discarded. This disposable device is then used to retain/contain the needle assembly for disposal. However, with such a design, it is difficult to insert the needle tip into the entry hole of the flange. The phlebotomist who does not have keen eyesight may take a long time in positioning the needle into the flange, or may miss the flange and receive a skin puncture. There is also risk of damaging the tip of the needle if the phlebotomist does miss the flange opening. The damaged needle tip may result in impaired flow through the tip, and other undesirable results. Thus, there is a need for a protection device that protects a phlebotomist from puncture by a used needle. Such a device may be utilized prior to sampling, for safe transport of the exposed needle, for sampling prior to disposal of the used needle, and for containing the used needle for disposal.
Zay talks to Andrew Hoepfner and Melinda Lauw of Whisper Lodge, a recent experiment in live ASMR experiences in New York. Zay caught up to the creators right after his experience in the lodge, so it's all super fresh. Meanwhile: we've got a raft of News & Notes from headquarters-- new shows, new reviews, and a tiny... Before you go any further, we just want to remind you that puns were once considered the highest form of wit... What happens when you put old friends in a room and get them talking about theatrical games? This episode of No Pro, that's what. Noah sits down with Myles Nye and Greg Snyder of The Wise Guys--whose careers... About the Podcast Exploring the renaissance in immersive theatre and interactive events. Hosted by Noah Nelson, creator of No Proscenium, a free events listing newsletter in Los Angeles, New York City, and San Francisco. Visit NoProscenium.com to sign up.
module.exports = require('./lib/babel.js')
# /ui/src/assets This folder contains assets that are copied by webpack to the build /dist folder.
Emergence of drug tolerance in cancer cell populations: an evolutionary outcome of selection, nongenetic instability, and stress-induced adaptation. In recent experiments on isogenetic cancer cell lines, it was observed that exposure to high doses of anticancer drugs can induce the emergence of a subpopulation of weakly proliferative and drug-tolerant cells, which display markers associated with stem cell-like cancer cells. After a period of time, some of the surviving cells were observed to change their phenotype to resume normal proliferation and eventually repopulate the sample. Furthermore, the drug-tolerant cells could be drug resensitized following drug washout. Here, we propose a theoretical mechanism for the transient emergence of such drug tolerance. In this framework, we formulate an individual-based model and an integro-differential equation model of reversible phenotypic evolution in a cell population exposed to cytotoxic drugs. The outcomes of both models suggest that nongenetic instability, stress-induced adaptation, selection, and the interplay between these mechanisms can push an actively proliferating cell population to transition into a weakly proliferative and drug-tolerant state. Hence, the cell population experiences much less stress in the presence of the drugs and, in the long run, reacquires a proliferative phenotype, due to phenotypic fluctuations and selection pressure. These mechanisms can also reverse epigenetic drug tolerance following drug washout. Our study highlights how the transient appearance of the weakly proliferative and drug-tolerant cells is related to the use of high-dose therapy. Furthermore, we show how stem-like characteristics can act to stabilize the transient, weakly proliferative, and drug-tolerant subpopulation for a longer time window. Finally, using our models as in silico laboratories, we propose new testable hypotheses that could help uncover general principles underlying the emergence of cancer drug tolerance.
The present invention relates to a device for use in the gearbox of an aircraft to help keep oil within the gearbox from leaking out into the atmosphere. During operation of the aircraft, pressures may build up within the gearbox. If these pressures are allowed to build up in excess, they may interfere with the normal operation of the various components of the gearbox. Accordingly, a vent usually is provided from the gearbox to relieve interior pressures.
Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines. Azole antifungal agents are widely prescribed drugs for the treatment of systemic fungal infections; however, since their introduction into the market, increasing evidences of hepatotoxicity have been reported. Therefore, we examined here the ability of three structurally different antifungal drugs, ketoconazole (KTZ), itraconazole (ITZ), and fluconazole (FLZ) to induce the CYP1A1, an enzyme known to play an important role in chemical activation of xenobiotics to toxic metabolites. KTZ and ITZ, but not FLZ, induced the CYP1A1 in murine Hepa 1c1c7 and human HepG2 hepatoma cells at the mRNA, protein and activity levels in a concentration- and time-dependent manner. The increases in Cyp1a1 mRNA levels mediated by KTZ and ITZ were completely blocked by the RNA synthesis inhibitor, actinomycin D, whereas the level of existing mRNA was not altered, implying a requirement of de novo RNA synthesis through a transcriptional mechanism. The ability of these drugs to directly activate the aryl hydrocarbon receptor (AhR) transformation and hence xenobiotic responsive element's binding was strongly correlated with their abilities to induce luciferase activity. Inhibition studies showed that KTZ and ITZ, in addition to being CYP1A1 inducers, are substrates and competitive inhibitors. This study provides the first evidence for the ability of KTZ and ITZ to induce the CYP1A1 gene expression through an AhR-dependent mechanism, and suggests a novel mechanism of the KTZ- and ITZ-mediated toxicities.
As we know, at present, power generation is a production process of converting, using a power generation device, thermal energy and nuclear energy of petrochemical fuel (such as coal, oil and natural gas) into electrical energy supplied for needs of various departments of national economy and people's life. However, petrochemical fuel can produce large amounts of carbon dioxide, which exacerbates the global greenhouse effect. Besides, nuclear energy faces great challenges of source of raw materials and environmental protection. Those skilled in the art have begun to use solar energy, wind energy, geothermal energy, water energy (including marine energy) and other clean energies for power generation. However, solar energy and wind energy are seriously affected by climatic conditions, and geothermal energy and water energy (including ocean energy) are subject to harsh geographical conditions as well. Therefore, these energies cannot be popularized on a large scale. Furthermore, long-term development of the ocean energy is prone to result in ecological disasters. Therefore, a kind of energy which is cheap and can be widely collected is needed. As a result, ubiquitous air, oceans, lakes and rivers come into people's sight. As all the energies on the surface of the earth substantially come from the sun (energy caused by volcanic eruption is relatively weak and can be negligible), the energy of the sun's rays is heating air, oceans, lakes and rivers all the time. If the energy can be extracted for human use, it will no longer have the problem of emissions of carbon dioxide, ecological disasters and the problem of scarcity of resources. Besides, the energy will no longer be subject to climatic conditions and geographical conditions. For the above reasons, a variety of power generation devices making use of air or liquid have been developed, where air or liquid thermal energy is used to make working fluids having a low boiling point in a vessel be gasified, and then high pressure steam generated is used to drive a generator to generate power through a turbine. However, at present, such devices are basically required to realize liquefaction recycling of the working fluids by means of a refrigeration compressor and a booster pump. The problems lie in that, on one hand, as the refrigeration needs to face enormous liquefaction potential, it is infeasible to use the refrigeration compressor to liquefy the working fluids, and on the other hand, even if there is a ready-made cold source, using the booster pump to make the working fluids back into a high pressure area costs highly. Therefore, the devices have too low overall efficiency and cannot be applied in practice. In addition, such devices have special requirements on working conditions, that is, they require a temperature difference, and the greater temperature difference the better. The devices cannot work in the case of no temperature difference. In view of the above situations, it is necessary to improve the power generation devices, to improve the efficiency of power generation and finally realize all-weather, all-earth and full-time power generation and even provide power under no temperature difference conditions.
Q: What is the meaning of 捅破 the serial of 寒夜? E.g. 被我们的学生捅破 The following text is taken from the serial of 寒夜: 一直到有一天一个偶然的机会我的心事或者说是我们的心事被我们的学生捅破感情是不能被捅破的一旦捅破就如同大坝破堤汹涌而出 He's talking about his love for the heroine of the series, then explains how the ice was broken. 捅破 is the problem word here. None of the dictionary definitions seem to fit. Actually, the following line referring to dams and dykes is also a bit cryptic. I thought a dam and a dyke are pretty similar but that doesn't fit if you want to understand the text. By the way, I'm in the process of transcribing both 新结婚时代 and 寒夜 with the aim of learning all the vocab and using the audio/video to get a feel for it all in context. Are the transcribed subtitles of any of these two already available somewhere? A: 捅破 comes from 捅破窗户纸 (poke the window paper). Try googling "捅破窗户纸". In the past, Chinese used paper instead of glass on their windows until the technology of making glass is imported to China. Window paper can stop the wind, but is much more fragile than glass and can be easily poked. Window paper is not transparent. If you poke a hole on it, you can see the other side. The two people loved each other, but they are too shy to tell each other. That's like there is a thin piece of paper hiding them from each other. Once it is poked, they can see each other. That is, they know how the other person feels. 捅破窗户纸 is also similar to "break the ice" in English. A: Think about that, there's a dam preventing they make a further step for their feelings/relationship. something or someone pokes a little hole on the dam, then the water just flood out...
Embodiments of the present invention relate to determining whether a configuration for an installed subsystem is suitable for operating the subsystem and to providing to an installed subsystem data for a suitable configuration. Conventional systems are packaged to facilitate maintenance and upgrades by permitting portions of a system to be removed and replaced with a functionally compatible replacement portion. Such portions may be equivalently referred to as subsystems, system components, replaceable units, or line replaceable units (LRUs). A subsystem may be operated by itself apart from the rest of the system for testing, though such operation may be somewhat different from typical system operation, for example, to facilitate diagnostics, analysis of extreme conditions, measurement, calibration, monitoring of internal signals, debugging, or special purpose tests. The specified performance of a subsystem is typically defined for system level operations and may also be defined at the subsystem level by specifying sequences of inputs and acceptable outputs of the subsystem. Certifying the performance of a subsystem typically includes ascertaining and recording the identity and configuration of the subsystem, isolating the subsystem from other system components (e.g., to assure performance isn""t masked by other subsystems), conducting tests using instrumentation that has been properly calibrated, recording that each step of a test was performed properly with an acceptable result, and recording that all testing was completed satisfactorily. The time, labor, equipment utilization, and management associated with certifying a subsystem represent a costly investment aimed at assuring proper operation of the system under all system operating conditions. Conventional subsystem design in electronics and software places emphasis on modular design techniques for decreasing development time. These modules may be circuits, circuit assemblies, memory devices, integrated circuits, application specific integrated circuits, or portions of software handled as a unit during software development processes. Such portions of software may include data or instructions in any form readable by human programmers or machines. Subsystems as a whole, and all internal modules, may be designed to perform according to one or more predefined configurations. Typically, a configuration corresponds to prescribed conditions of signals at an electrical interface of the subsystem or module, or to prescribed contents of a memory device. A configuration may establish an initial operating mode (or set of modes) or may, upon configuration change, establish a different mode (or set of modes) for further operations. Conventional subsystems have been designed to operate with centralized control of subsystem modules. For example, all hardware and software modules for an airplane cockpit system function such as a collision avoidance system computer for a collision avoidance system have been packaged as a line replaceable unit. Also, a system may be installed in a variety of environments, each characterized by different system operations or operational modes. Consequently, for a given subsystem, all modules that may be necessary or desirable for all system environments have typically been included in the subsystem. As the number of environments and the complexity of the system and subsystem increase, the cost of certification of the subsystem has dramatically increased. Without systems and methods of the present invention, further development of systems and subsystems may be impeded. Development, operating, and maintenance cost targets and performance reliability goals may not be met using conventional system design as discussed above. Consequently, important systems for assuring safety of personnel and equipment may not implemented to avoid injury, loss of life, and destruction of property. A system, according to various aspects of the present invention, operates in an aircraft and includes several cooperating subsystems. At least one of the subsystems is coupled to an environment memory having content and a plurality of signature values of respective portions of the content. That subsystem includes a nonvolatile memory, an interface, and a processor. The nonvolatile memory includes content and at least one signature value of the content of the nonvolatile memory. The interface facilitates removal and replacement of the subsystem. The processor has access to the environment memory via the interface. The processor validates the content of the nonvolatile memory with reference to the signature value of the content of the nonvolatile memory, validates the content of the environment memory with reference to at least one signature value of the content of the environment memory, updates the content of the nonvolatile memory in accordance with the content of the environment memory, and performs a program in accordance with the updated content of the nonvolatile memory. By using signatures stored in environment memory and in nonvolatile memory, the processor may easily recognize that the subsystem has been removed from one system and installed in another system. After updating the content of nonvolatile memory, the program operates in a certified configuration for the system where the subsystem is now installed. A subsystem, according to various aspects of the present invention, operates in a system in accordance with contents of a system memory that is not part of the subsystem. The system memory includes content and a plurality of signature values of respective portions of the content of the system memory. The subsystem includes a nonvolatile memory, an interface, and a processor. The nonvolatile memory has content and a signature value of the content. The interface facilitates removal and replacement of the subsystem. The processor has access to the system memory via the interface. The processor validates the content of the nonvolatile memory with reference to the signature value of the content of the nonvolatile memory, validates the content of the system memory with reference to at least one signature value of the content of the system memory, updates the content of the nonvolatile memory in accordance with the content of the system memory, and performs an application program in accordance with the updated content of the nonvolatile memory. A tray, according to various aspects of the present invention, accepts a replaceable subsystem. The tray includes an interface and a memory. The interface facilitates removal and replacement of the subsystem. The memory is coupled to the subsystem via the interface. The memory includes a plurality of signatures, each signature associated with a respective portion of the content of the memory. In one implementation, the memory is housed in the shell of a connector of a cable assembly that connects to the subsystem. By storing a signature in the memory for each of several portions of content, the identity and certification status of that portion of content may be easily ascertained. Greater flexibility results in defining memory content when the identity of each portion of content is independent of its storage location in memory. A method, according to various aspects of the present invention, operates a subsystem of an avionics system. The avionics system has a plurality of subsystems. The subsystem is packaged as a replaceable unit for installation via an interface of the subsystem. The subsystem includes a processor and a first memory. The system includes a second memory accessed by the subsystem via the interface. The method is performed by a processor of the subsystem and includes in any order: (a) determining a first calculated signature of a first content of the first memory; (b) comparing the first calculated signature with a first stored signature stored in the first memory to conclude validity of the first content; (c) determining a second calculated signature of the second memory, the second memory comprising a plurality of stored signatures for respective portions of the content of the second memory; (d) comparing the second calculated signature with a second stored signature stored in the second memory to conclude validity of the second content; (e) updating the first content in accordance with the second content in response to determining that the first content is valid and the second content is valid and a difference exists among at least two of the first calculated signature, the second calculated signature, the first stored signature, and the second stored signature; and (f) performing an avionics program in accordance with the updated first content. By determining validity before performing an avionics program, the avionics program may be performed in a certified configuration. A method, according to various aspects of the present invention operates a subsystem of an avionics system. The avionics system includes a plurality of subsystems. The subsystem being packaged as a replaceable unit for installation via an interface of the subsystem. The subsystem includes a processor and a first memory. The avionics system includes a second memory accessed by the subsystem via the interface. The method is performed by a processor of the subsystem. The method includes in any order: (a) determining whether first content of the first memory is not complete, determining being with reference to a preferences store of the subsystem; and (b) transferring second content from the second memory to the first memory, the second content being identified by a signature. Use of a signature simplifies identification of portions of content to assure that a preferred certified configuration of an application program is used by the subsystem.
package com.xabber.android.ui.adapter.chat; import android.view.View; import com.xabber.android.data.database.messagerealm.MessageItem; public class NoFlexForwardedVH extends ForwardedVH { public NoFlexForwardedVH(View itemView, MessageClickListener messageListener, MessageLongClickListener longClickListener, FileListener listener, int appearance) { super(itemView, messageListener, longClickListener, listener, appearance); } @Override public void bind(MessageItem messageItem, MessagesAdapter.MessageExtraData extraData, String accountJid) { super.bind(messageItem, extraData, accountJid); if (messageText.getText().toString().trim().isEmpty()) messageText.setVisibility(View.GONE); } }
AutonomousVmClusterSummary ========================== .. currentmodule:: oci.database.models .. autoclass:: AutonomousVmClusterSummary :show-inheritance: :special-members: __init__ :members: :undoc-members: :inherited-members:
/** * Copyright (c) Microsoft Corporation. All rights reserved. * Licensed under the MIT License. See License.txt in the project root for * license information. * * Code generated by Microsoft (R) AutoRest Code Generator. / package com.microsoft.azure.management.cognitiveservices.v2017_04_18; import rx.Observable; import com.microsoft.azure.management.cognitiveservices.v2017_04_18.implementation.ResourceSkusInner; import com.microsoft.azure.arm.model.HasInner; /* * Type representing ResourceSkus. / public interface ResourceSkus extends HasInner<ResourceSkusInner> { /* * Gets the list of Microsoft.CognitiveServices SKUs available for your Subscription. * * @throws IllegalArgumentException thrown if parameters fail the validation * @return the observable for the request */ Observable<ResourceSku> listAsync(); }
The present invention relates generally to gas turbine engines, and, more specifically, to noise reduction therein. In an aircraft turbofan gas turbine engine, air is compressed, mixed with fuel, and ignited for generating hot combustion gases which flow downstream through turbine stages and are discharged as a jet with corresponding thrust. The turbines power a compressor, and also power a fan which produces a majority of the propulsion thrust for powering an aircraft in flight. The propulsion air and jet exhaust are two sources of engine noise. The reduction thereof is an environmental objective and is typically accomplished using various techniques including higher bypass ratio turbofans, acoustic liners inside the engine ducts and fan nacelle, and exhaust mixers. A principal source of fan noise is the interaction between the fan rotor blades and stator vanes or struts downstream therefrom. The fan has a rotational speed N and effects a blade passing frequency (BPF) which is the product of the rotational speed N and the number B of rotor blades. The fan air generates spinning mode noise produced by rotating pressure fields and wakes caused by the rotor blade, and the interaction thereof with the adjacent stator vanes. This noise is emitted from the engine both upstream through the inlet of the fan duct and downstream through the duct outlet. The spinning mode noise occurs at discrete frequencies including the fundamental blade passing frequency BPF, which is also a first harmonic, and higher order frequencies or harmonics thereof. In order to ensure the decay of spinning mode noise, it is known to select the number of vanes to be greater than or equal to twice the product of the number of blades and the blade passing frequency harmonic number. For example, decay of the first harmonic spinning mode noise may be achieved using a number of vanes greater than or equal to twice the number of blades. Higher harmonic noise decay requires even a greater number of vanes which is impractical to implement in a turbofan engine. Notwithstanding the various techniques available for reducing fan and jet noise in a turbofan engine, residual noise is still significant. Accordingly, it is desired to further reduce fan and jet noise in an improved manner.
Zymographical techniques for detection of matrix metalloproteinases. Matrix metalloproteinases (MMPs) are a family of zinc-dependent proteinases associated with extracellular matrix degradation, cellular migration, tissue remodeling, and angiogenesis. The activity of MMPs is regulated by the tissue inhibitors of metalloproteinases (TIMPs). Zymography and reverse zymography are useful to detect MMPs and TIMPs activities from various samples, for example vitreous, retina, plasma, and so on. Sample proteins are separated in substrate containing polyacrylamide gel by electrophoresis. The gel is incubated and then stained with Coomassie Blue. MMPs' activities are detected as clear bands.
Heart transplantation for end-stage cardiomyopathy caused by an occult pheochromocytoma. Dilated cardiomyopathy has been found in patients with pheochromocytoma. The cardiomyopathy and resultant congestive heart failure can be progressive and fatal, or reversible, if the source of the excess catecholamines is removed. Histologic and autopsy studies revealed a characteristic focal myocarditis and contraction band necrosis, indicating that the circulating catecholamine excess secreted by the pheochromocytoma is the cause of the cardiomyopathy.
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Room Lighting: Using Lighting in a Bedroom Room lighting is an issue in numerous American homes that is best drawn closer from both a sensible and an imaginative perspective. The utilization of lighting in a room can be part into three expansive goals. These are to give light, to improve the room style and to be advantageous to utilize. We will move toward every one of these both coherently and imaginatively. Room Lighting: Let There be Light The major reason for room lighting is to give light. Some lighting is utilized uniquely for its creative properties, however not in the room. Individuals need light to dress and uncover by, for applying beauty care products, to peruse with and on a very basic level just to not be uninformed. So the lighting in a room must be viable. Having built up that, it would then be able to be utilized for its improving properties. There are a few distinct kinds of room lighting accessible, each expected for an alternate reason. Among these are: Roof lights: for general space lighting. The most well-known sorts are utilized as a solitary light with a lampshade, or gathering of lights contained in a roof lighting unit. A crystal fixture is an outrageous case of the last mentioned, yet the central reason for existing is to light the whole room. In certain homes that is the main accessible lighting in the room. Table lights: these frequently come two by two, one on every night represent a twofold bed. Their essential capacity is to give light to perusing by, albeit once more, in a couple of rooms, this is just wellspring of lighting. Spotlights: spotlights are utilized for coordinated lighting; to a dresser for instance. They are not a methods for general space lighting and are seldom utilized for perusing. Mirror lights: these are regularly appended to a mirror – the top or the sides – and give light to applying beautifying agents and other such employments. There are different types of room lighting to be discovered, for example, divider lights which again are a type of room lighting. Be that as it may, those above are by a wide margin the most well-known types of lighting in a room. Utilizing Lighting in a Bedroom as Decorative Accents Having accomplished its essential capacity, every one of the above can likewise be utilized beautifully. The shades are accessible in a practically boundless scope of shapes, sizes, plans and hues. In any room, the lights will in all likelihood adjust to a specific beautifying topic, regardless of whether that is only a shading plan. In a couple of cases the lights themselves will be hued, extending from pinks and reds to golden and blues. Regularly such lights will be utilized as a highlight in a specific zone of the room, as opposed to as the primary methods for giving light. They will either match or appear differently in relation to the general room stylistic theme, or be utilized as a shaded embellishing accent. The Convenience of a Bedroom Lighting System One issue with a solitary light in a room is its bother. Except if fitted with two switches, the room will be in dimness, either before they are turned on or after they have been turned off. Numerous individuals use lights on their end tables or on the divider over their headboard. They would then be able to at present have light when the primary light is stifled. Another answer for this is an infrared-worked light switch. This is worked by a remote control, and can be utilized once you are sleeping to turn off the lights. This is the most advantageous approach to control your room lighting. Outline When picking lighting in a room, you should take every one of the above components into thought. You may not intentionally do as such, however you will probably have every one of the primary three factors at the top of the priority list. The vast majority will ensure they have satisfactory lighting in their room and will either coordinate that to their stylistic layout or pick something other than what’s expected as a complexity. They will likewise ensure that their room lighting can be stifled from their bed. In saying that, it is astonishing what number of individuals still need to stroll to the entryway to switch of the light, and afterward bumble back to their bed in obscurity. Try not to leave that alone you. There is no compelling reason to rework – just supplant your light switch with a remotely enacted one.
"Stückelberg interferometry" with ultracold molecules. We report on the realization of a time-domain "Stückelberg interferometer", which is based on the internal-state structure of ultracold Feshbach molecules. Two subsequent passages through a weak avoided crossing between two different orbital angular momentum states in combination with a variable hold time lead to high-contrast population oscillations. This allows for a precise determination of the energy difference between the two molecular states. We demonstrate a high degree of control over the interferometer dynamics. The interferometric scheme provides new possibilities for precision measurements with ultracold molecules.
The Art of Seating I always end up sitting in the wrong seat. When they were handing out the rulebook on how to master the art of seating, I was dossing down the back of the room. Some people are able to glide towards a seat as if they were born to do it it. I usually end up flailing. For example, I never grasped the rule about women taking the inside seat. I was staying at a B&B once and the owner was getting a table ready for a couple who were due to come down. He was pushing the table away from the wall, because he maintained that the woman would want to sit on the inside seat, closest to the wall. Lo and behold, the woman sat on the inside. I thought he had magical divining powers, but Husband shrugged. ‘Women always sit on the inside.’ he said. Well, I don’t. When you take the inside seat, you’re always having to lean out to where the conversation is. And that’s not my style. I want to sit on the outside, at the beating heart of the conversation. Seating Large Numbers Then there’s the restaurant seat scramble. When a large group of people is going to a restaurant or pub, the most mild-mannered people become ruthless scrum-halves, in a bid to bag the prime seating, away from the table bore. I find myself paralysed. My feet won’t propel me forward, and I end up in no-man’s land. It’s possible that I’m the table bore they’re looking to avoid, but I flatter myself that this isn’t so. People scramble for seats at restaurants. Pic from Pixabay. Or there’s the peculiar hell inflicted on wedding guests, when the bride and groom places them at a table with an odd assortment of human beings, After a few hours at a wedding table, wading through the treacle of small talk, you start to think that a few hours in a holding cell would have been preferable. Seating at Venues When I go to the cinema or theatre, I’m careful to position myself at the centre of the row. If I sit at the edge, I’ll constantly have to be getting up for people. I fancy I leave enough seats on either side of me for groups to sit down. Yet these groups will insist on passing me to go to the seats on the other side, so I have to get up anyway. Leaving me to wonder what’s wrong with the seats on either side of me. Then there’s the seating magnet at restaurants. This is the magnet that compels restaurant staff to place you and your partner a hair’s breadth away from the next table, despite the fact that the restaurant is almost deserted, and there are vast acres of space where you could eat your meal in private. Do they fear we may need to huddle together for warmth? Or do they feel the walk between tables would be too great? We scramble for seating because we’re eager to conquer the space around us. Unfortunately, we have to share that space with other human beings, and this brings out the competitive urge in us. Hence the scramble for prime seating. I’m hoping there’s a catch-up class I can take so I can acquaint myself with that rulebook on the art of seating, so I can one day be that person who glides up to a seat as if born to it.
Targeting interferons as a strategy for systemic sclerosis treatment. Systemic Sclerosis (SSc) is an autoimmune disease characterised by vasculopathy, uncontrolled inflammation and enhanced fibrosis which can subsequently lead to the loss of organ function or even premature death. Interferons (IFNs) are pleiotropic cytokines that are critical not only in mounting an effective immune response against viral and bacterial infections but also strongly contribute to the pathogenesis of SSc. Furthermore, elevated levels of IFNs are found in SSc patients and correlate with skin thickness and disease activity suggesting potential role of IFNs as biomarkers. In this review, we summarise existing knowledge regarding all types of IFNs and IFN-inducible genes in the pathogenesis of SSc. We then argue why IFN-blocking strategies are promising therapeutic targets in SSc and other autoimmune diseases.
London Lions reserves earned warm praise from Adam Fisher, manager of Codicote reserves, after the league leaders were made to sweat in the Herts Senior County League Reserve Division One contest at Rowley Lane. Nick Goodman and Daryl Phillips spurned Lions’ best two chances in a first half they enjoyed the better of, in a game where Adam Joselyn was man of the match. Fisher said: “I’m obviously delighted with the win against a very good side. Our first half performance was no way near what we all have come to expect and we were totally outplayed.”
Video Flames GM talks about moves made prior to free agency Just days before National Hockey League free-agent frenzy, Flames GM Brad Treliving spoke to media about the recent moves acquiring goalie Eddie lack from the Carolina Hurricanes and signing right-winger Kris Versteeg to a one-year contract.
Q: Use duality to find a strong alternative Find a necessary and sufficient condition for the linear equation Ax = b to have no solution. (hint: Use duality to find a strong alternative to Ax = b). A: Solution exists iff $b$ is orthogonal to the null space of $A^{*}$. This is typically referred to as the Fundamental Theorem of Linear Algebra.
Menu What to Wear: Fall Floral To make the chillier temps a bit more bearable, embrace fall’s freshest florals. It’s clear that summer’s sweet floral prints are sticking around for fall. Key is to embrace muted hues that blend well with fall tones and are slightly heavier fabrics. I fell in love with this beautiful bell sleeved dress from For Love & Lemons from the shape to the gorgeous colors. Please don’t start dressing in all black, at least not yet! Pick gorgeous rich colors that make you feel pretty and polished. Bell sleeves, open-toed booties and a power satchel, says it all. So we might feel sandwiched between seasons, but it’s the perfect time to embrace some wardrobe-envy pieces.
Q: Can a page raise an event that the user control can handle? I have done this the other way many times as it makes sense (the page knows about the control as it has been added to the page and can handle the 'child' event) Is it possible to do it the other way? I think not as the control doesn't know what page it is going to be on The reason i ask this is that I have a modal popup on the page to ask users to login, and it is only when the user has logged in that I want my user control to go away and execute some code but I am not too sure how to tell the control this has happend? A: Total Friday afternoon 'my mind is fried' question, all i needed to do was have a public sub on the user control that the page could call once the login was complete! I vote to close on account of my stupidity
X-ray devices used in the medical field contain an X-ray tube which typically includes a cathode which is heated to emit electrons, a (typically rotating) anode having a target surface facing the cathode, and a surrounding glass and/or metal frame containing an X-ray-transparent window secured by a window mount. Some emitted electrons strike the target surface at a focal point and produce X-rays, and some of the X-rays exit the frame as an X-ray beam through the X-ray-transparent window. Other emitted electrons do not produce X-rays and are backscattered when they strike the focal point on the target surface. Many of the backscattered electrons go on to strike and heat the frame including the X-ray-transparent window and the window mount. It is known to place an electron collector between the focal point and the X-ray-transparent window to capture backscattered electrons that would otherwise strike and heat the X-ray-transparent window, wherein the electron collector has a central hole to permit passage of the X-ray beam. The heated frame is typically cooled by a liquid coolant, such as oil or water, located between the frame and a surrounding casing. The dissimilar coefficients of thermal expansion of the X-ray-transparent window and the window mount generate mechanical stresses which can cause tube failure. Additionally, high temperatures in the X-ray-transparent window itself can induce boiling of the adjoining liquid coolant. Such coolant boiling will degrade the quality of the X-ray beam which exits the frame through the X-ray-transparent window. Existing grounded metal frame tubes include those having high-cost components to mechanically join the window to the rest of the frame while reducing thermal stresses to acceptable levels. Some known tubes have enhanced cooling applied to the window region. It is also known that the backscattered electrons can create a thermal hot spot on the frame and can burn a hole through a glass frame. Such hot spot is located on the frame apart from the X-ray-transparent window and the window mount. Reducing the power of the X-ray beam and/or increasing cooling to the thermal hot spot region are known techniques used to overcome this problem. What is needed is an improved X-ray tube design which reduces heating of the X-ray-transparent window and the window mount from backscattered electrons.
Q: How do I say that I called someone? For example if I wanted to say "I called bob", would it be something like "私は Bob の電話を呼びました"? That sentence feels a little awkward and I'm not sure how to properly phrase it. A: 「電{でん}話{わ}をかけた」is one option, and「電話（を）した」is another. There's also「電話を入{い}れた」, which tends to be used in more 'functional' contexts, like if the call was made to inform/notify the other party about something or in order to confirm something. You would use each of these after starting with「ボブに」in the given example. To convert these to somewhat more polite versions, you can replace the final「～た」 with「～ました」. A: A way I learned to say this is ボブに電話をかけました。 The に indicates a "destination" in the same way ～に聞きました means asking ~ a question. jisho entry
Genotoxic Maillard byproducts in current phytopharmaceutical preparations of Echinodorus grandiflorus. Extracts of Echinodorus grandiflorus obtained from dried leaves by three different techniques were evaluated by bacterial lysogenic induction assay (Inductest) in relation to their genotoxic properties. Before being added to test cultures, extracts were sterilized either by steam sterilization or ultraviolet light. Only the extracts prepared by infusion and steam sterilized have shown genotoxic activity. The phytochemical analysis revealed the presence of the flavonoids isovitexin, isoorientin, swertisin and swertiajaponin, isolated from a genotoxic fraction. They were assayed separately and tested negative in the Inductest protocol. The development of browning color and sweet smell in extracts submitted to heat, prompted further chemical analysis in search for Maillard's reaction precursors. Several aminoacids and reducing sugars were cast in the extract. The presence of characteristic Maillard's melanoidins products was determined by spectrophotometry in the visible region and the inhibition of this reaction was observed when its characteristic inhibitor, sodium bisulfite, was added prior to heating. Remarkably, this is the first paper reporting on the appearance of such compounds in a phytomedicine preparation under a current phytopharmaceutical procedure. The genotoxic activity of such heat-prepared infusions imply in some risk of developing degenerative diseases for patients in long-term, uncontrolled use of such phytomedicines.
The present invention relates to a method and system for incremental database maintenance, and in particular to updating materialized views in a database. In a data warehouse, views are computed and stored in the database to allow efficient querying and analysis of the data. These views stored at the data warehouse are known as materialized views. In order to keep the views in the data warehouse up to date, it is necessary to maintain the materialized views in response to the changes at the sources. The view can be either recomputed from scratch, or incrementally maintained by propagating the base data changes onto the view so that the view reflects the changes. Incrementally maintaining a view can be significantly cheaper than recomputing the view from scratch, especially if the size of the view is large compared to the size of the changes. The problem of finding such changes at the views based on changes to the base relations has come to be known as the view maintenance problem and has been studied extensively. Traditional maintenance techniques propagate insertions and deletions from the base relations to the view through each of its operations. Several improved schemes have been proposed for incremental maintenance of view expressions. However, problems arise with traditional techniques and with prior improved schemes. For example, none of the previously known schemes efficiently handles the case of general view expressions involving aggregate and outerjoin operators. As another example, most of the incremental maintenance approaches compute and propagate insertions and deletions at each node in a view expression tree, which is often inefficient. A need arises for an incremental maintenance technique which efficiently handles general view expressions involving aggregate and outerjoin operators. The present invention is a method and system for incrementally maintaining a database having at least one materialized view based on at least one table. When changes to the table are received, a change table based on the received changes is generated. The generated change table is propagated upwards to form a higher-level change table and the materialized view is updated by applying the higher-level change table to the materialized view using a refresh operation. In one aspect of the present invention, the change table includes a plurality of tuples representing the changes and the materialized view includes a plurality of tuples. The refresh operation has two parameters, a join condition and an update function specification. The materialized view is updated by finding all tuples in the materialized view that match the tuple in the change table, using the join condition, for each tuple in the change table and updating each found tuple in the materialized view by performing operations indicated by the update function specification. In one embodiment of the present invention, the materialized view is an aggregated materialized view. In this embodiment, each tuple in the materialized view and in the change table includes at least one aggregated attribute and may include one or more non-aggregated attributes. Tuples in the materialized view that match the tuple in the change table are found, using the join condition, by matching the non-aggregated attribute of a tuple in the change table, if any, with the non-aggregated attribute of a tuple in the view. Each found tuple in the materialized view is updated by updating the aggregated attribute of the tuple in the view using the aggregated attribute of the tuple in the change table. In one aspect of this embodiment, the materialized view is further updated by inserting a tuple from the change table into the materialized view, if no tuples are found in the materialized view that match the tuple from the change table, and deleting a tuple from the materialized view, if an aggregated attribute representing a count of a number of tuples in a group represented by a the tuple becomes zero. In another embodiment of the present invention, the materialized view is an outerjoin materialized view based on a plurality of tables. In this embodiment, there is a tuple in the materialized view corresponding to each value of at least one selected attribute in any of the plurality of tables. Each tuple in the materialized view comprises at least one selected attribute and at least one other attribute. Tuples in the materialized view that match the tuple in the change table are found, using the join by matching the at least one selected attribute of a tuple in the change table with the at least one selected attribute of a tuple in the view. Each found tuple in the materialized view is updated by updating the at least one other attribute of the tuple in the view using the at least one other attribute of the tuple in the change table. In one aspect of this embodiment, the materialized view is further updated by inserting a tuple from the change table into the materialized view, if no tuples are found in the materialized view that match the tuple from the change table and deleting a tuple from the materialized view, if a value of the at least one selected attribute of the tuple is no longer present in any table.
Q: Literature on FX market-maker hedging strategies Specifically, FX market making. I am not exactly looking for market-making strategies, but rather when once a market-maker has assumed a net position in a currency spot trading market, what are some optimal ways of hedging that position, measures of exposure, how often the hedge should be rebalanced optimizing to reduce transaction costs etc. Any pointers to books or papers are appreciated! A: take a look at Giles Jewitt's "FX Derivatives Trader School". A clear, concise yet exhaustive read. Highly recommend.
Podcasts, lectures and more from Pacific Lutheran University. Located in Tacoma, Wash., PLU seeks to educate students for lives of thoughtful inquiry, service, leadership and care—for other people, for their communities and for the Earth.
Kenya Accommodation - Lodges and camps Safari lodges and camps Most accommodation in the bush is based around a 'site' that has a fascinating history: an old hunting camp, a scout observation point, a salt lick or a colonial retreat, always located in the most desirable spots with stunning views and excellent game-viewing. You can choose bettween tented camps, lodges and tented lodges. Tented camps are designed to be samll and intimate and can be found in a wide variety of styles, from simple to luxurious. Tents are extremely spacious, comfortable, en-suite and totally protected from outside elements. Lodges tend to be larger more structured accommodation, where designs often take on the look and feel of their surroundings.Rooms are similar to modern hotels and include all the creature comforts one would expect in the bush. Tented lodges, having all the luxuries, characteristics and functions of a bush lodge, walls have simply been replaced by reinforced canvas.
Semantic Treatments for Word and Sentence Production Deficits in Aphasia. The cognitive domains of language and memory are intrinsically connected and work together during language processing. This relationship is especially apparent in the area of semantics. Several disciplines have contributed to a rich store of data about semantic organization and processing, and several semantic treatments for aphasic word and sentence production impairments have been based on these data. This article reviews the relationships between semantics and memory as they relate to word and sentence production, describes the aphasic language impairments that result from deficits in these areas, and summarizes treatment approaches that capitalize on what we have learned about these domains and how they work together.
Arm and leg substrate utilization and muscle adaptation after prolonged low-intensity training. This review will focus on current data where substrate metabolism in arm and leg muscle is investigated and discuss the presence of higher carbohydrate oxidation and lactate release observed during arm compared with leg exercise. Furthermore, a basis for a possible difference in substrate partitioning between endogenous and exogenous substrate during arm and leg exercise will be debated. Moreover the review will probe if differences between arm and leg muscle are merely a result of different training status rather than a qualitative difference in limb substrate regulation. Along this line the review will address the available studies on low-intensity training performed separately with arm or legs or as whole-body training to evaluate if this leads to different adaptations in arm and leg muscle resulting in different substrate utilization patterns during separate arm or leg exercise at comparable workloads. Finally, the influence and capacity of low-intensity training to influence metabolic fitness in the face of a limited effect on aerobic fitness will be challenged.
History of benzodiazepine dependence. The benzodiazepines were developed in the 1950s, some introduced in the 1960s, and many more since then. Pharmacologically, they are sedative/hypnotics akin to alcohol, chloral, the barbiturates, and meprobamate. All have been widely used both within and outside the licit medical context. Usage of benzodiazepines increased dramatically during the 1960s and early 1970s; tranquilizer but not hypnotic usage has since declined. Both abuse and misuse were documented early, but the incidence was deemed low in view of the widespread prescription. Normal-dose physical dependence was first suspected in the early 1970s but it was not until the early 1980s that scientific evidence was adduced to establish its reality and frequency. Further studies have revealed the complex nature of the withdrawal syndrome. A reaction has set in against these drugs, with attempts to limit them to short-term use.
..Administration of cocaine by different routes alters the amount of cocaethylene formed through hepatic first-pass effects. Increased cardiovascular and subjective effects might explain the toxicity and popularity of the combined drugs...
This Program Project is designed to provide funds for four projects and one core facility. The studies of the four projects will focus on the intra- and extra-cellular signals which determine the fate of lymphocytes at various stages of their life history. Particular attention will be paid to the factors which affect whether lymphocytes live or die, since the phenomena which control the proliferation and differentiation versus tolerance of lymphocytes are absolutely crucial to the health of the animal. The investigators on the first project have developed a method for isolation of very early lymphocyte progenitors. They will use these cells to find out which transcription factors they express, and how these transcription factors may affect cell development. The functions of these cells and their descendants will also be studied. The studies of the second project will deal with the effect of antigen valency on the fate of lymphocytes. The third project will concentrate on the properties of memory T cells and will study the properties which distinguish these cells from other types of T cells. The investigatory on the last project have discovered that the fate of antigen activated T cells in animals is affected by inflammatory processes. Experiments will be done to find out why antigen- activated T cells die in animals, and how inflammation prevents this death.
In a network environment, a packet needs to be forwarded from a source node to a destination node along a forwarding path, so that a data packet is forwarded, and data is transmitted. The source node is also referred to as an ingress node (Ingress Node), and the destination node is also referred to as an egress node (Egress Node). For a network environment that supports multiprotocol label switching (MPLS), different mechanisms may be selected to forward packets, such as an Internet Protocol (IP) routing mechanism, an MPLS mechanism, and a segment routing (SR) mechanism. In packet forwarding mechanisms such as the MPLS mechanism and the segment routing mechanism, the forwarding path is also referred to as a label switched path (LSP). In a process of forwarding a packet in a network, some service processing needs to be performed on the packet sometimes. For example, when a forwarding node on a forwarding path of the packet has multiple links for selection, to implement load balance on the forwarding node, the forwarding node needs to select, according to a load status of each link, a link to forward the packet. In the prior art, for a forwarding equivalence class (FEC), to perform service processing on a packet corresponding to the FEC in a forwarding process of the packet, some forwarding nodes on a forwarding path of the FEC need to be statically configured, so that these forwarding nodes can process, in a statically configured service processing manner, the packet corresponding to the FEC. However, because there are a large quantity of FECs in the network environment, and a service processing manner of each FEC needs to be configured for different forwarding nodes, a large quantity of forwarding nodes in the network need to be statically configured. Consequently, work of configuring and maintaining service processing for the network environment is extremely complex, and it is difficult to flexibly implement various service processing in the network environment.
Atherothrombosis and plaque heterology: different location or a unique disease? Formation of unstable plaques frequently results in atherothrombosis, the major cause for ischaemic stroke, myocardial infarction and peripheral arterial disease. Patients who have symptomatic thrombosis in one vascular bed are at increased risk of disease in other beds. However, the development of the disease in carotid, coronary and peripheral arteries may have different pathophysiology suggesting that more complex treatment protocols may have to be designed to reduce plaque development at different locations. In this review we describe the known risk factors, compare the developmental features of coronary and carotid plaque development and determine their association with end-point ischaemic events. Differences are also seen in the genetic contribution to plaque development as well as in the deregulation of gene and protein expression and cellular signal transduction activity of active cells in regions susceptible to thrombosis. Differences between carotid and coronary artery plaque development might help to explain the differences in anatomopathological appearance and risk of rupture.
Lyrics 作詞 : Shi Jun Wei 史俊威 Composer 作曲 : Shi Jun Wei 史俊威 Producer 編曲 : Xu Qian Xiu 徐千秀這條路好漫長時光逼著我們長大 On the long road of life, passing time forces us to grow old 好多話不能講只有把酒言歡地藏 So many words remain unsaid, even those drunken truths remain hidden in your heart 這世界說大不大 This world isn’t as big as it seems 一生能有多少的失望 How much disappointment can fill one life? 一人能裝多少的希望 How much hope can fill one person? 我最盼望有一雙翅膀 My greatest wish is to grow wings 能夠帶我飛離這城牆讓我們都一樣 To fly over these city walls until we all look the same 停不了對夢想的渴望 If you can’t bear to give up on your dreams 那就放膽一搏再去闖一闖 Then gather up your courage to try again Tomorrow will be fine. Tomorrow I’ll be fine. Tomorrow we’ll be fine. 黑夜裡的亮光放在心裡自問自答 The light in the dark makes me question myself 對不起我好傻並不只是一句氣話 “I’m sorry” “It’s all my fault” are more than angry words 再一起地老天荒 Let’s stay together until the world ends 一生能有多少個願望 How many possibilities can one life hold? 我最盼望有一雙翅膀 My greatest wish is to grow wings 能夠帶我飛離這城牆讓我們都一樣 To fly over these city walls until we all look the same 停不了對夢想的渴望 If you can’t bear to give up on your dreams 那就放膽一搏再去闖一闖 Then gather up your courage to try again Tomorrow will be fine. Tomorrow I’ll be fine. Tomorrow we’ll be fine. 穿過雲間的光照在人間 That’s what we promised each other after all 這是我們宣告的信念 To fly above the clouds and shine 我最盼望有一雙翅膀 My greatest wish is to grow wings 能夠帶我飛離這城牆讓我們都一樣 To fly over these city walls until we all look the same 停不了對夢想的渴望 If you can’t bear to give up on your dreams 那就放膽一搏再去闖一闖 Then gather up your courage to try again Tomorrow will be fine. Tomorrow I’ll be fine. Tomorrow we’ll be fine.
Over the years, insomniacs have been offered pills, plants, “mindfulness”, and even special lamps to help them get off to sleep. But it now turns out that a far simpler solution has always been at hand, and one that is, literally, all around: the great outdoors. New research suggests that rather than lying in bed miserably counting imaginary sheep, insomniacs should get out among some real ones and try a spot of camping.
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Phase separation dynamics of polydisperse colloids: a mean-field lattice-gas theory. New insights into phase separation in colloidal suspensions are provided via a dynamical theory based on the polydisperse lattice-gas model. The model gives a simplified description of polydisperse colloids, incorporating a hard-core repulsion combined with polydispersity in the strength of the attraction between neighbouring particles. Our mean-field equations describe the local concentration evolution for each of an arbitrary number of species, and for an arbitrary overall composition of the system. We focus on the predictions for the dynamics of colloidal gas-liquid phase separation after a quench into the coexistence region. The critical point and the relevant spinodal curves are determined analytically, with the latter depending only on three moments of the overall composition. The results for the early-time spinodal dynamics show qualitative changes as one crosses a 'quenched' spinodal that excludes fractionation and so allows only density fluctuations at fixed composition. This effect occurs for dense systems, in agreement with a conjecture by Warren that, at high density, fractionation should be generically slow because it requires inter-diffusion of particles. We verify this conclusion by showing that the observed qualitative changes disappear when direct particle-particle swaps are allowed in the dynamics. Finally, the rich behaviour beyond the spinodal regime is examined, where we find that the evaporation of gas bubbles with strongly fractionated interfaces causes long-lived composition heterogeneities in the liquid phase; we introduce a two-dimensional density histogram method that allows such effects to be easily visualized for an arbitrary number of particle species.
import ModalDialog from 'ember-modal-dialog/components/modal-dialog'; import { computed } from '@ember/object'; import { getOwner } from '@ember/application'; export default ModalDialog.extend({ renderInPlace: computed(function() { let config = getOwner(this).resolveRegistration('config:environment') return config.environment === 'test'; }) });
Depression imposes a very high societal burden in terms of cost, morbidity, suffering, and mortality. It is the leading cause of disability in the Unted States and the fourth leading cause worldwide. Current methods of treatment are insufficient to combat such a widespread health problem. Therefore, addressing this mental health epidemic requires significant changes in intervention strategies. A growing body of research is examining the use of behavioral intervention technologies (BITs), such as mobile phones to deliver behavioral and mental health interventions. The delivery of interventions via mobile phones offers the potential to provide a near continuous connection between a care system and the patient. However, currently available mobile applications (apps) for depression lack evidence regarding their efficacy. App stores currently offer apps for depression that are designed based on cognitive therapy (CT) interventions, some with behavioral activation (BA), some with mood monitoring only, and many with no discernable psychological approach. Even when based on psychological theory, there is no evidence that the translation of these theories, developed for face- to-face treatment, work the same way for people with depression when delivered through an app. Given the quickly evolving nature of mobile apps, conducting research on every available app will never be possible, nor very useful. The proposed research plan takes an innovative approach to investigating BITs for depression by incorporating principles from psychology, engineering, and design to examine two primary psychological principles, CT and BA, delivered by mobile apps. The project will include two stages. First, the most usable elements of existing apps will be identified to create two apps, one using CT and the other BA, targeting depressive symptoms. This usability process will use a clear, model-driven approach to identify the most usable and useful characteristics for three app elements: information delivery, tools, and visual feedback. Following usability testing and improvements, the two apps will be subjected to a small comparative trial. Secondary aims will include an examination of usage of the apps, defined as how many times the apps are opened on the mobile devices. Results will provide information that can be broadly used by developers of apps for depression and may also have implications for apps aimed at treating other mental health disorders.
A cloud of dust followed the team and wagon into the yard of the grain elevator, and I set my broom against a wall and watched the farmer maneuver the wagon up the ramp into the scale shed. Herman Pearson was a wiry man with a face like a ferret, thin-nosed, small-chinned, with a sparse crop of graying hair. But under his bushy brows, his eyes were merry, bright with humour and kindliness. I watched him expertly handle the team, lining them out over the scale, which was a real feat, considering that Herman had only one arm. “I left it in France,” he’d say, patting his shoulder indulgently, as if the errant arm had had better things to do in a foreign country beyond the sea. The wheels of the wagon settled into the cradle on the scale deck, and Herman jumped down, landing lightly. He unhitched the team, leading the horses forward. “Let ‘er go,” he hollered, and the elevator agent activated the mechanism that would tip the wagon up and empty the grain. The golden flood cascaded through the grate, dust billowing in powdery clouds. I stood by Herman, to see better, and it was then I noticed Herman’s crisply ironed shirt, the collar turned down neatly. The bright cotton was sprinkled liberally with dancing green teapots and smiling pineapples. Herman caught me looking at the shirt and he grinned. “Like it, do you? The missus sewed it. Made herself an apron to match and dresses for the girls. Lovely, eh?” Doubt must have shown on my face, because Herman gave a hearty chuckle. “Not so sure? Yer thinkin’ a growed man shouldn’t be wearin’ duds made outta flour sacks?” It wasn’t that exactly, for my own shirt was made from a flour sack, a tan and blue plaid, faded and well patched, used for working at the elevator or in the field. It was the jolly green teapots cavorting with the pineapples that made me smirk, disrespectfully, I fear. Not even the sight of the empty sleeve, pinned up, was going to quench the snicker I could feel welling up, relentless as the grain pouring from the wagon. “Let me tell you somethin’, son. When I was in France, during the Great War, I seen things that would curl yer toes. My pal, Tommy Diggs, breathed in the mustard gas. Thought he was gonna cough out his insides, but no, he were spared that, gettin’ hisself shot instead, dying in the trench covered with mud, blood, and things you’d rather not hear about.” I felt bad for Tommy Diggs, suffering from the gas, and then getting shot after all, but that was the way of war, with so many not coming home. The horses stood patiently, heads down, glistening hides occasionally twitching, and tails flicking at flies. I wondered if Herman’s arm, holding the lines, was getting tired. A fine trail of sweat trickled down his neck into the collar of the shirt. “The missus and me’d only been married one day before I took the train to Halifax, then sailed across the Atlantic. After the tortures I seen in them trenches, I knowed life would be mighty good if I were lucky enough to come back.” I didn’t see what the war had to do with the cheerful green teapots on Herman’s shirt, but I knew if we stood long enough in the hazy heat, he’d tell me. “Then I took a chunk of shrapnel in my arm. I says, Herman, it’s just an arm and I got another one. Jus’ think of poor ol’ Tommy, rottin’ in the muck. Yes, sir, I were lucky.” I waited. “If the missus wants ter make me shirts with teapots, that’s fine. If she were to make somethin’ with waltzing purple giraffes, I’d be proud to wear it. Fact be knowed, I picked out these flour sacks myself, thinkin’ the missus’d make towels.” Laughing gleefully at his own observation, he re-hitched the team to the emptied wagon, whorls of choking dust swirling around the horses’ hooves. “So long, son.” Herman nodded farewell as he clattered off the scale deck, his one hand holding the lines. I’ll admit, I was covetous of the unabashed way he confidently wore the shirt with the green teapots. A cheap sacking shirt made and worn with love, as if it were the finest linen. I was with you from the beginning to the end of this story. I agree with the other reviewer - you do seem to be able to write well with not much effort. Now, that might cause one to be green with envy! LOL Laura “If the missus wants ter make me shirts with teapots, that’s fine. If she were to make somethin’ with waltzing purple giraffes, I’d be proud to wear it. Fact be knowed, I picked out these flour sacks myself, thinkin’ the missus’d make towels.” I absolutely love these lines. Ah true love! You sure know how to spin a good yarn! I am always in awe of your storytelling. So much character..so much unforced back story woven in...all within this tiny word limit. Perfect prose, as always. (On a complete sidenote, the second paragraph describing Herman's face made me think of ol' ferret face Frank Burns from MASH. Lol;) Congrats, Ann! I enjoyed this, especially the ending. I grew up hearing about WWI (the great war) from my grandfather and my grandmother make clothing and bedding from the flour sacks. This took me back.
product description page Sticker Art Jungle (Paperback) About this item Create your own colorful jungle animal portraits with this new sticker series for animal enthusiasts of all ages. With eight sticker by number portraits for hours of fun, each portrait features facts to keep young readers interested.
Despite what your dispenser will tell you, glass lenses are still available in this country. Plastic lenses are not really "safer" than glass lenses, but they're a hell of a lot more profitable - eyecare "professional" my ass.
Hybrid navigation Hybrid navigation is the simultaneous use of more than one navigation system for location data determination, needed for navigation. By using multiple systems at once, the accuracy as a whole is improved. Especially for self-driving cars, the exact and continuous knowledge of the navigating object's location is essential. Function GPS or other satellite based systems (GLONASS, GALILEO, BEIDOU, QZSS) provide a way to learn one's location, but these methods require free field conditions in order to receive the radio signal. Various satellite systems are subject to switching-off or reduction of data precision by the company or government that runs them. They are also prone to intentional or unintentional disturbances. Even passing through a tunnel or a garage interrupts the data flow. In situations where the signal cannot be received reliably, alternate sources of location data are needed. Combining GPS with other methods can avoid these limitations, but each method has its own specific limitations. A hybrid system provides fault tolerance for each underlying method and improves the overall precision of the result. The hybrid system needs to decide how to choose among the different methods at any given time. One solution is a triple configuration, allowing 'result voting' for data collecting systems. Alternate systems that supply navigational data include: Inertial navigation systems. This system determines location by summing the movement vectors from start of the trip or some other waypoint whose location is well-defined. Incremental sensors. This system uses vehicle speed data supplied by a Fleet Management System. Differential GPS. This system uses terrestrial radio transmitters with well-defined locations that broadcast information about how accurate the GPS signals are at identifying the locations of these transmitters. See also Automotive navigation system Navigation Data Standard External links Homepage of 'Deutschen Gesellschaft für Ortung und Navigation (DGON)' Wildau Video References Category:Mobile technology Category:Communication Category:Navigational equipment
Back in August, we alerted you to the PlayStation Plus-exclusive Assassin's Creed Revelations beta which is now live on PlayStation Network. But today, Sony revealed that the beta will now be open for all PlayStation Network users beginning tomorrow, September 8th. The PlayStation Blog reported that starting at 10am PT, everyone can download the beta from the PlayStation Store and get in on the action. The beta only runs until Sunday, September 11th, however, so if you want to start playing, you better do so as soon as you can!
Fears Rosemount site will remain vacant A resident of Denman in the New South Wales Hunter Valley is concerned Muswellbrook Council's decision to reject Orica's plans for the old Rosemount Winery site might set a precedent for future proposals in the area. Councillors unanimously rejected the development application for the ammonium nitrate storage facility on Tuesday night. One of the reasons given was that Rosemount Road is not of a suitable standard to handle an increase in heavy vehicle traffic. While business owner Steve Carter is relieved Orica's plans will not be going ahead, he fears the old winery will remain unused. "The council rejected this proposal, largely on the state of the Rosemount Road," he said. "I have a feeling that if there's a more suitable development planned for that site, better for jobs and whatever, that it may also end in the same fate that Orica did." The site once featured Rosemount's wine production facility and cellar door and was one of the most visited wineries in the Hunter Valley. Moscow's words and actions — including the alleged poisoning of a former spy — are not the results of random aggression but rather fall into distinct patterns that can help us anticipate Russia's next moves under Vladimir Putin.
Social marketing: an underutilized tool for promoting adolescent health. Social marketing applies some of the same principles used in commercial marketing for the analysis, planning, execution, and evaluation of programs designed to motivate voluntary behavioral change. It relies on consumer research for understanding the people they hope to change, including their values, aspirations, fears, lifestyle, and factors that motivate and deter them from adopting desired behaviors. Social marketing has been applied in public health settings since the 1980s for promoting such behaviors as safer sex, hypertension and cholesterol control, reduced occurrence of alcohol-impaired driving, improved utilization of public health prevention and screening services, and enactment of better school nutrition policies in schools. Although most evidence for social marketing's utility comes from interventions directed at adult audiences, its application with adolescents may help to address issues that have been challenging or unresponsive to health behavior change specialists. This article describes the basic tenets of social marketing as a behavior change process, identifies its previously successful applications with adolescent audience segments, and offers both lessons learned and projected future applications that employ emerging communication technologies.
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In August, United States marshals, acting on behalf of the F.D.A., seized vials of smallpox vaccine that was being used to create a stem cell product that was being given to cancer patients at the California clinics. The product posed a risk to those patients of inflammation of the heart and surrounding tissues, the agency said. The California center trains other physicians in how to extract stem cells and has affiliates around the country. A Florida woman, Doris Tyler, lost her sight after being treated at an affiliate, the Ageless Wellness Center in Peachtree City, Ga. Cells from her fat were injected into both eyes. Dr. Berman said that many people had been helped by his clinic and that he had tried to work out a compromise with the F.D.A. but was unable to do so. He also said he believed the cells that are harvested from individuals do not constitute a drug and should not be regulated as such. In its statement, the F.D.A. also said that both the U.S. Stem Cell Clinic and the California Stem Cell Treatment Center were using cell extracts to treat serious conditions — including Parkinson’s disease, amyotrophic lateral sclerosis and chronic obstructive pulmonary disease — but that their products were not approved for any use. The F.D.A. oversight of stem cell therapies and regenerative medicine is still in flux. In August, Dr. Scott Gottlieb, the agency’s commissioner, called the field one of the most promising areas of science and medicine, holding great promise for some of the world’s most intractable illnesses. He vowed that the F.D.A. would ease the path to approval for researchers and companies that were developing legitimate treatments — a program authorized by Congress in the 21st Century Cures Act. At the same time, however, Dr. Gottlieb vowed to crack down on clinics making hollow claims and marketing unsafe treatments. He also announced the action against the California Stem Cell Treatment Centers in Rancho Mirage and Beverly Hills and against the U.S. Stem Cell Clinic. In November, the F.D.A. continued work along both themes. The agency acknowledged the difficulty in pursuing rogue clinics and suggested that consumers check up on stem cell clinics before receiving treatment.
Dutch Elm Disease Dutch Elm Disease (DED) is an invasive fungus spread to American Elms via the native elm bark beetle. This disease has killed off many American Elms in urban forests but with the help of the Province of Manitoba it has been managed for a number of years. To learn about DED, signs, symptoms, and the management program click here.
Electronic circuits typically include a number of components. These components can be discrete devices, or provided as part of integrated circuits. Whether provided as discrete devices or integrated circuits, multiple electronic components are often interconnected to one another by placing those components on a common printed circuit board. In addition to providing a structural member to which components can be attached, a printed circuit board typically provides traces on one or more layers to conduct power and signals to and between attached components. When used in connection with implementing complex circuits, the design of the individual circuit boards can also become quite complex. In addition, where a large number of components are to be interconnected to a printed circuit board, the area of the board can become quite large, and a relatively large number of layers may be required to provide the necessary connective traces. In addition to providing conductive traces, certain electronic components can be integrated directly into a printed circuit board. One consideration in the design of electronic circuits is the size of those circuits. In particular, by making devices smaller, certain performance parameters can be improved, and the device can be easier to package and transport. Also, it can be desirable to maintain electronic circuitry within size limits that are defined by certain components of a device implemented using the electronic circuitry or a component of that circuitry. One example of electronic circuitry that can be quite complex, but that is desirably deployed within a relatively small area, is a phased array antenna. In a phased array antenna, multiple antenna elements or radiators are deployed across a surface. The size of each antenna element is generally determined by the intended operating frequency or frequencies of the antenna. Furthermore, as more antenna elements are provided, the antenna beam can be more narrowly focused and directed by applying selected phase delays to the signal comprising the beam that is delivered to (or received from) each of the antenna elements. That is, by varying the delay of a signal, the corresponding beam can be scanned along one dimension for a one dimensional array of antenna elements and along two dimensions for a two dimensional array of elements. In addition, the maximum scanning angle that can be provided by an antenna will increase as the space between antenna elements is decreased. Accordingly, the radiator or antenna elements of a phased array antenna generally occupy an area that is defined by the size of the individual antenna elements, the number of antenna elements, and the spacing between antenna elements. Within the area defined by the antenna elements of a phased array antenna, on a side of a circuit board opposite the side on which the antenna elements are formed, circuits have been developed that allow the phase delay of two separate beams to be controlled. However, where a phased array antenna is intended for simultaneous communications with or tracking of a larger number of targets, it is desirable to increase the number of beams that can be individually controlled. This has been difficult or impossible to achieve using conventional techniques in connection with the circuit board on which the antenna elements are formed. In addition, because higher frequencies generally require a smaller antenna element, it has been especially difficult to provide supporting circuitry for systems designed to operate at high frequencies. In order to provide the area necessary for complex beam forming networks, additional circuit boards containing components of the beam forming network can be placed behind the board on which the antenna elements are formed, for example on circuit boards arranged perpendicular to the antenna element boards. That is, the space available for circuitry can be expanded into three dimensions. Although such systems provide a place for the circuitry required to provide a number of steered beams, they do not address issues of design difficulty and ease of expansion. In particular, each board or other unit of circuitry typically includes elements that are unique to that board.
Q: Idea about RESTful server Ok, I had this argument with a friend about on how do we tackle data process in a restful environment. The main idea is the application sends a data which is a position of the device (lat & long) to the server and expected to ping back the nearest device. My argument was the process of determining the "nearest device" in the latlong position should be done in the server and just ping back the latlong of the nearest device. Friend said that the process should be like this.. the server will pingback a json of every device with its latlong and the client itself will then determine the which one is the nearest. A: Look at it this way: A server is a datahub where all data is stored and processed. A client is something that fetches data from a server, presents data to the user, and takes input from him. Now you have to think about Seperation of Concerns. A client's job is to view data to a user, and take his input. A server's job is to process all data and transform it in such a way that a client needs to do minimal processing on it. I.e. a client fetches some data from the server, all he should have to do now is show it on the screen. There should be minimal data processing on the client side. This is the server's job. The server's job is to make the client's job as easy as possible. A client also has other things to do on the background (maybe also for other applications). It's CPU is not dedicated to your application, while your server's is. What does a client need? The nearest device. What does the client ask the server? "Hey server, tell me what is the nearest device.". What should the server return? Exactly, the nearest device. Not a list of all devices which the client has to dig through himself.
[Changes in the lipid-accumulating cells of the liver during experimental hypervitaminosis A]. Changes of the fat-storing cells (FSC) in the liver have been studied after oil solution of vitamin A have been injected to intact rats, when Kupffer's cells have been blocked with colloid silver and stimulated with prodigiosan. During these experiments (on the 4th, 7th, 14th days) the amount of FSC does not change, and their size increases. The blockade of Kupffer's cells does not influence the dynamics of the FSC changes, and their stimulation contributes to lipid accumulation in their cytoplasm and to earlier revealing of these elements (on the 2d day of the experiment). In parallel with increasing size of FSC, fatty infiltration of hepatocytes disappears and reticular fibers accumulate in the perisinusoid space. Participation of FSC in lipid metabolism and in synthesis of the III type collagen is proved, as well as existence of intercellular interactions of these elements with endotheliocytes, Kupffer's cells and hepatocytes.
Molecular basis for structural heterogeneity of an intrinsically disordered protein bound to a partner by combined ESI-IM-MS and modeling. Intrinsically disordered proteins (IDPs) form biologically active complexes that can retain a high degree of conformational disorder, escaping structural characterization by conventional approaches. An example is offered by the complex between the intrinsically disordered N(TAIL) domain and the phosphoprotein X domain (P(XD)) from measles virus (MeV). Here, distinct conformers of the complex are detected by electrospray ionization-mass spectrometry (ESI-MS) and ion mobility (IM) techniques yielding estimates for the solvent-accessible surface area (SASA) in solution and the average collision cross-section (CCS) in the gas phase. Computational modeling of the complex in solution, based on experimental constraints, provides atomic-resolution structural models featuring different levels of compactness. The resulting models indicate high structural heterogeneity. The intermolecular interactions are predominantly hydrophobic, not only in the ordered core of the complex, but also in the dynamic, disordered regions. Electrostatic interactions become involved in the more compact states. This system represents an illustrative example of a hydrophobic complex that could be directly detected in the gas phase by native mass spectrometry. This work represents the first attempt to modeling the entire N(TAIL) domain bound to P(XD) at atomic resolution.
Steam In-Home Streaming Monopolizes Host Computer Valve announced last week that their new Steam feature will be moving into beta before the end of the year. Today, a Q&A with more information on the streaming service was released. While a game is being streamed from your PC or Mac to another device, the host computer is unable to be used. According to the Q&A, the stream monopolizes the computer as it “is dedicated to running the game and input is coming from both the remote client and the local system.” Streaming is also not accomplished via the internet. The streaming feature is designed for home-streaming. Internet streaming isn’t supported at the moment, forcing gamers to use local networks. Eventually, Valve hopes to combine this streaming feature with their Steam Machines and SteamOS to create an open gaming network. If you’d like a chance to participate in the beta and check out In-Home Streaming for yourself, you can join the Homestream group on Steam. Participants will be randomly selected from Steam account-holders who are members of this group. But, for now, all we can do is speculate. What are your thoughts on the Steam In-Home Streaming feature?
One of the methods currently used for the in-flight refueling of aircraft comprises the use of a boom provided with an internal section with capacity for telescopic extension via which aircraft fuel is transferred by means of an internal line from the tanker aircraft to the receiving aircraft. The boom is connected to the tanker aircraft by means of a hinged system provided with two degrees of freedom and is equipped with a set of movable aerodynamic surfaces or fins which, by means of independent variations of the incidence of each of them relative to the incident air flow, enables the operator of the system to position the boom in the conditions of desired attitude. The limit of the attitude envelope attainable depends on the maximum capacity of said fins for generating forces that make it possible to balance the set of aerodynamic, inertial and gravitational effects relative to the linkage of the system. Movement of the boom from one position of equilibrium in space to another is effected by using these fins, with their initial and final positions corresponding to those that balance the boom in both spatial conditions. Said movement is a movement of rotation about each of the two axes defined by the two degrees of freedom of the linkage (elevation-roll or elevation-azimuth). The dynamic characteristics of said system correspond to a modal description characterized by a very low damping ratio. Consequently this movement generated by a direct change of fins from that corresponding to equilibrium in one spatial position to another spatial position involves an oscillatory movement of the boom with very little damping. To accomplish the precise and predictable operation of tracking of the refueling socket or receiver of the receiving aircraft, without running the risk of causing an impact between the recipient and the boom, it is necessary for the movement of the latter to be sufficiently damped. For achieving this aim, the prior art employs electrical control systems (fly-by-wire), with functions for increasing stability and control, in such a way that the dynamics of movement, by means of said control system, has the desired characteristics for performing the task of tracking the receiver. An electrical flight control system comprises: Elements for measuring movement and/or position of the platform to be controlled, called sensors. A control element in the operator's cabin, generally a joystick, for controlling the movements required by the operator. Actuating elements that generate the movement of the control elements of the platform, in this case the aerodynamic surfaces. An on-board computer or calculating system with on-board software that includes algorithms which, when supplied with the orders generated by the operator, together with the measurements of movement and/or position of the equipment, generate a command for movement of the control elements, via their actuating systems. The algorithms implemented in the on-board computer are directed towards modification of the natural dynamics of the equipment to be controlled as well as provision of other functions such as a manoeuvre or position demand system. In the case of the in-flight refueling boom system, the control algorithms must perform a basic function of increasing the damping of the basic equipment, from a very low value, close to zero, up to a value compatible with a rapid and predictable response without oscillations or exceeding of the final value demanded. This desired response is associated with appropriate operating conditions for performing the task without requiring significant compensation of the dynamics of the equipment by the operator. The increase in damping is achieved by means of a command for movement of the aerodynamic fins so that they generate a load, producing an overall force on the boom that tends to oppose the angular movement of the latter. The damping effect is achieved by means of a fin movement of a magnitude related to the angular velocity (normally a proportional relation) and opposite in direction to this angular movement. The basic characteristics of the refueling system necessitate increased damping of the angular movements defined by both linkages (elevation-roll or elevation-azimuth). Owing to the fact that in the design of the refueling probe the length of the probe predominates, as well as its lowest possible weight, the structural characteristics of the boom are characterized by particular modes with extremely low frequencies. These frequencies are close to the natural frequencies that define the movement of the boom as a rigid solid about the linkage and the frequency of control thereof used by the operator for controlling said movement. These flexible modes are also characterized by a very low damping ratio, exhibiting a very characteristic resonance frequency with a high level of amplification of the response if excited at said natural frequency. The flexible modes of the probe are excited when subjected to external loads, such as the forces generated by the fins in the process for controlling the position of the boom. The excitation through movement of the aerodynamic surfaces has two origins: one due to the change in aerodynamic load on changing its angle of incidence, the other due to the inertial loads caused by rotation about its axis of rotation. In the case of the in-flight refueling boom, the effect of generation of aerodynamic load is dominant. The elements of the flight control system that detect the movement of the boom measure the movement of the section of the boom where the measuring elements are located, detecting both the movement as a rigid solid, the control object thereof, and the movement associated with the flexible vibration of the structure. Therefore the control algorithms are fed with the rigid and elastic movements, which are converted by these algorithms into a demand for movement of the aerodynamic fins. By their movement, these in their turn generate new forces which in addition to acting on the movement of the boom as a rigid solid, once again excite the structural modes. This combination of rigid and elastic movements is fed again to the control system, and a coupling effect is produced. The effect of coupling of the flexible movement of the structure with a control function as a rigid solid is called “structural coupling”. The excitation of the structure through movement of the aerodynamic fins decreases as the frequency increases, owing to the natural attenuation of the actuating system, as well as the intrinsic capacity for generation of aerodynamic force. This effect of feedback of the movement must be such that the resultant dynamics are stable, and must moreover guarantee a margin relative to the condition of instability of the complete system, formed by the equipment to be controlled plus its control system. In the qualification of system airworthiness, minimum stability margins are specified both in the control of the rigid modes, and in the stability of the flexible modes. In the phenomenon of structural coupling, the closeness of the rigid and the flexible control frequencies is critical, therefore the first flexible modes are of low frequency and are relevant to the phenomenon. The dominant flexible mode will be regarded as that having greatest influence on the problem of structural coupling, i.e. by its frequency, by a low damping ratio, by excitation due to the deflection of aerodynamic fins or by its detection by means of the elements for measuring movement or position. A first measure for reducing this phenomenon is to locate the measuring systems in positions that are not altered by the movement due to the flexible modes relevant to the phenomenon, or even to locate the control surfaces at a point of less excitation of the structure. Whereas the location of the elements for measuring movement can at times have some flexibility during design, the positioning of the control surfaces has to satisfy the capacity for control and balancing of the equipment. In any case, positioning of the measuring elements in a position that is not altered by the movement due to the relevant flexible modes is not a robust solution owing to the change of these modes with possible changes in configuration of the equipment, as is the case with the movement of extension of the telescopic tube in the case of the refueling boom. In the case of the boom, the aerodynamic fins must be positioned to be sufficiently remote from the linkage to produce a balancing moment about the linkage by means of a force that is as small as possible. The measuring elements can be located in the sections that interfere as little as possible with the transverse section of the boom, so that the aerodynamic drag does not increase significantly. These can be positioned at the root of the boom and in the section with the fins. The usual techniques for avoiding the phenomenon of structural coupling are based on performing signal filtering, whether those obtained via the measuring systems, and the signals for command of fin movement, in such a way that there is no change in content of the signal with respect to measurement of rigid movement. The negative effect of said filtering is that the more we wish to attenuate the content of the flexible signal at high frequency, the more phase lag is induced in the signal in the range of control frequencies as a rigid solid. This phase lag means that the maximum damping ratio that could be obtained by means of feedback is limited. The greater the phase lag, the lower will be the maximum damping ratio attainable by means of feedback, and therefore the handling qualities that can be achieved will be poorer. In the case of the in-flight refueling probe, the closeness of the flexible frequencies and the control frequencies means that the usual method of filtering cannot be used for simultaneously achieving the objectives of guaranteeing the required stability margins and providing adequate handling characteristics for performing the task of tracking of the receiver. The present invention aims to correct this shortcoming.
What are the pros and cons of using analysts who are predominantly former high-ranking military officers to present their opinions in a public news medium? One benefit of using former high-ranking military officers as public news analysts, also called pundits, concerns the fact that journalists are limited in their areas of expertise. As TV executives and news producers see it, "Journalists can't know everything"; therefore, it becomes very useful and even necessary for news producers to have experts on call (Tugend, "Pundits for Hire"). Former high-ranking military officers have contacts and "specialized knowledge about strategy, weapons, and tactics that most journalists don't have," making them key contacts for their comments on war ("Pundits for Hire"). In general, many agree that using pundits has provided the public with more expertise than has ever been available before. However, using pundits can of course raise ethical questions. A journalism professor named Richard Schwarzlose, who specializes in ethics, has raised an ethical concern with respect to paying experts for their expertise. When experts are paid for their expertise, what they say can be called into question, especially when television is concerned. Everyone knows that television is all about entertainment and delivering "colorful and provocative commentary" regardless of facts ("Pundits for Hire"). Hence, many are concerned that when paid, pundits may become willing to say whatever needs to be said to keep getting paid, leading to intentional distortion of the facts. Also, some experts may be tempted to protect their paid positions as consultants by providing comments on a debate even if they aren't truly experts on particular facets of a story. Another danger with using pundits concerns lack of objectivity. Most pundits are naturally respectful of the military and therefore pro-Pentagon, which means they give viewers only a pro-Pentagon side of the story. However, that's not the case for all pundits. Both retired generals Bary McCaffrey of NBC and Wesley K. Clark of CNN openly criticized the "Bush administration's war plan, questioning whether their were enough U.S. forces in Iraq to get the job done" ("Pundits for Hire"). Hence, while pundits certainly do have their own levels of expertise, they also have their own opinions and even biases.
Get breaking news alerts and special reports. The news and stories that matter, delivered weekday mornings. A member of Vice President Mike Pence's staff has tested positive for the coronavirus, Pence's office said Friday night. The staffer's name and exact position was not released, but Pence's press secretary, Katie Miller, said, "Neither President Trump nor Vice President Pence had close contact with the individual. "Further contact tracing is being conducted in accordance with CDC guidelines,” Miller said. Pence, who was placed in charge of the White House coronavirus task force in late February, said earlier this week he had not been tested for the virus himself. "I'm in regular consultation with the White House physician and he said I've not been exposed to anyone for any period of time who has the coronavirus," he told reporters on Monday. "My wife and I have no symptoms, but we’re checking our temperature regularly every day and will continue to follow guidance." Trump tested negative for the virus last week, after he was in close contact with multiple people at his Mar-a-Lago resort in Florida who had been exposed to the coronavirus.
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Evidence that asthma is a developmental origin disease influenced by maternal diet and bacterial metabolites. Asthma is prevalent in Western countries, and recent explanations have evoked the actions of the gut microbiota. Here we show that feeding mice a high-fibre diet yields a distinctive gut microbiota, which increases the levels of the short-chain fatty acid, acetate. High-fibre or acetate-feeding led to marked suppression of allergic airways disease (AAD, a model for human asthma), by enhancing T-regulatory cell numbers and function. Acetate increases acetylation at the Foxp3 promoter, likely through HDAC9 inhibition. Epigenetic effects of fibre/acetate in adult mice led us to examine the influence of maternal intake of fibre/acetate. High-fibre/acetate feeding of pregnant mice imparts on their adult offspring an inability to develop robust AAD. High fibre/acetate suppresses expression of certain genes in the mouse fetal lung linked to both human asthma and mouse AAD. Thus, diet acting on the gut microbiota profoundly influences airway responses, and may represent an approach to prevent asthma, including during pregnancy.
By Culted J. Z. Knight [as Ramtha] is now pandering to the GOP and Trump. Rosanne Barr has had a lot of association with Ramtha recently. Both Roseanne and JZ are heavy Second Amendment supporters. Roseanne has been seeking Ramtha for spiritual guidance in phone calls and both are rabid Trump supporters. Anyone who lives near the Ramtha School of Enlightenment knows that it borders a thick forest that is owned by the US Military. There are some people who follow Ramtha who live out in those woods. There is a small encampment that has been living there literally for decades. The encampment is known as “the people who lost everything to Ramtha.” They are the truly devoted. It’s hard to get to and locate in the thick forest, but the encampment is actually only a few hundred yards from another part of the school – the Maze. As part of their training, people are put in the Maze and they have to try to get out. They often act like frenzied rats trying to escape. Sometimes this drill can last for many hours at a time, with people being literally stuck in the ever-changing maze. I think that originally Knight did not intend to commit crimes, but things got out of control with the Pyramid Schemes and colored Trek Pants. Miss a class, you start all over, even if that means camping in a PsyOps drill called Paradise Beach, where one can be left out for days at a time in cold, wet weather, often scheduled during February or November, where temperatures are often in the forties or colder. It was rumored that JZ Knight and Linda Evans were having an affair for a while. Linda helped finance the Ramtha school along with John Derek’s daughter. {Evans was married to Derek.] JZ became famous when she appeared on the Merv Griffin show. Merv gave JZ her first big exposure. The reason for that is because Merv and JZ’s ex-husband were gay and JZ’s ex-husband knew Merv and arranged her appearance. Also, if you look at the later year plot lines of the TV show Dynasty, it is almost a mirror image of how JZ crafted her image: the UFO plot lines, the horses, two of the characters of Dynasty moved to the Seattle area. That’s because some of the writers also joined the Ramtha cult after the show wrapped. Lots more to be said about Ramtha I hope that Catherine Oxenberg’s next book will be about Ramtha, now that she nabbed NXIVM. [Her book Captive was such a good read.] Hopefully, Linda Evans will fast track a biography about her Ramtha years before others cash in. Linda’s time out of the limelight has been too long and she needs a comeback like Oxenberg did thru her association with NXIVM. The Ramtha lawyers are to be feared though. Time and time again they have shut people down and shut them up into silence. I doubt Frank Parlato will get very far before Ramtha sues. Share this: Twitter Facebook Email Print LinkedIn More Reddit Like this: Like Loading...
The unique passion, energy, and obsession of Philadelphian basketball community can be tough to fully understand and capture for people who come into the community from the outside. Thankfully for Diana Venezia, she had already grown up with a large window looking into the city’s basketball culture at the collegiate level, so diving into work serving its foundation — our city’s young people — was a challenge she was excited and prepared for. Although she grew up an hour…
A module in a module system is associated with a particular name. Modules refer to each other by their respective names. For example, one module may declare a dependency on another module, referring to the depended-upon module by name. However, a module may be renamed. For example, a module may be generated using an automatically assigned name (e.g., assigned by an integrated development environment (IDE)) and may later be renamed using a user-assigned name. As another example, a company may be acquired and subsequently change its module names to reflect the acquisition. Many different reasons for renaming a module exist. When a module's name changes, consumers of that module (e.g., other modules depending on that module) may break, i.e. cease to function properly, if the consumers are not edited to reference the new module name. Specifically, when a consumer attempts to access a module using its old name, an error may be generated and/or the consumer may encounter errors when attempting to reference the module using its old name. Editing every reference to an old module name, in each of the module's consumers, may be time-consuming, expensive, and/or simply impractical. For example, the developers of a module that is released for use by other developers generally do not have access to edit consuming modules' code. One approach to renaming a module may be to declare multiple names for that particular module. In other words, the module system may include a single module that can be referenced by multiple names. However, allowing a single module to have multiple names may require the programming environment, compiler, and/or runtime environment to keep track of the multiple names and ensure that references to each of those names resolve to the same module. Thus, allowing a single module to be have multiple names may be resource-intensive and/or error-prone. The approaches described in this section are approaches that could be pursued, but not necessarily approaches that have been previously conceived or pursued. Therefore, unless otherwise indicated, it should not be assumed that any of the approaches described in this section qualify as prior art merely by virtue of their inclusion in this section.
"Holy shit." "You all right?" " Yeah." " Hershel?" "Let's head back." "Car." "Car." "Get down." "Dave?" "Tony?" "They said over here?" "Yeah." "I'm telling you, man, I heard shots." "I saw roamers, two streets over." "Might be more around here." "It's hot." "We gotta get out of here." "Dave!" "Tony!" "Shut up, idiot!" "You wanna attract them?" "Just stick close." "We're gonna find them." "Dude, he said to stay close." "Tony." " They should've been back by now." " Yeah." "They just got holed up somewhere." "We'll head out first thing in the morning." " Thank you." " Welcome." "Thanks." "Carl, I want you to keep your head up, okay?" "Your old man, he's the toughest son of a..." "No cussing in the house." "Sorry." " Lori, dinner." " She's not in there." "Where is she?" "Carl, when's the last time you saw your mom?" "This afternoon." "She was worried about Rick, asked me to look in on Carl." " She went after them?" " She didn't say that." "Nobody panic." "Gonna be around here somewhere." " Why won't they leave?" " Would you?" "We can't sit here any longer." "Let's head out the back and make a run to the car." " What happened?" " Roamers." "I nailed them." " They disappeared, but their car's still there." " I cleared those buildings." " You guys get this one?" " No." "Me neither." "We're looking for Dave and Tony and no one checks the damn bar?" "What?" "Someone pushed that shut." "There's someone in there." "Yo, is someone in there?" "Yo, if someone's in there, we don't want no trouble." "We're just looking for our friends." "What do we do?" "Bum rush the door?" "No, we don't know how many are there." "Just relax." "We don't want any trouble." "We're just looking for our friends." "If something happened, tell us." "This place is crawling with corpses." "If you can help us not get killed, I'd appreciate it." "Dude, you're bugging." "I'm telling you nobody's in there." "Someone guard the door." "If they're in there, they might know where Dave and Tony are." "They drew on us!" "Dave and Tony in there?" "They alive?" " RICK:" "No." " They killed Dave and Tony." "Come on, man, let's go." "No, I'm not leaving, I'm not telling Jane." "I'm not gonna go back and tell them that Dave and Tony got shot" " by some assholes in a bar." " Your friends drew on us!" "They gave us no choice!" "I'm sure we've all lost enough people, done things we wish we didn't have to, but it's like that now." "You know that!" "So let's just chalk this up to what it was, wrong place, wrong..." "Get outta here!" "Go!" "We can't find Lori." "And the others aren't back yet either." "That dumb bitch must've gone off looking for them." " What?" " Yeah, she asked me to go." "I told her I was done being an errand boy." "And you didn't say anything?" "Don't do this." "Please." "I've already lost my girl." "Yeah, that wasn't my problem neither." " She's not at the barn." " I checked the yards." "Well, where is she?" "She asked Daryl to go into town." "Must've gone herself." "Hey." "Carl." " Did you know about this?" " No." "Look, just, did she take a gun?" "I don't know." "I wouldn't let her go out there alone." "Hey!" "We all know this is not gonna end well!" "There's nothing in it for any of us!" "You guys, just back off, no one else gets hurt!" "Shit!" "Glenn!" "Glenn!" "I'm all right." "I'm all right." "Lori!" "I'll hold them here." "You cover Glenn." "See if you can make it to your car." "Tell him..." "Tell him to pull up back." "We'll run for it, get the hell out of here." "You want me to cover Glenn?" "You missed all that gun training." "It could've come in handy now." "I can shoot." "I just don't like to." "Sorry." "Sorry." "Rick wants you to try for the car." " Try?" " You'll try and succeed." " I'll cover you." " That's a great plan." " What happened?" " He fired." "He must've hit Glenn." "He's behind the dumpster." " Doesn't look like he's moving." " Help!" "You hit?" "Are you hit?" "No." "No." " It's all right." "The car's right there." " Okay." "We're almost home." " You good?" " I'm good." "Let's go." "Get back." "Let's get out of here!" "Roamers all over the place!" "Hurry up!" " We gotta get out of here!" " What about Sean?" " They shot him." " We gotta go." "Roamers are everywhere." " We're leaving?" " Jump!" "Hurry up, jump already." "Dude didn't make it." " Help me!" "Help me!" " I've gotta go." "I'm sorry!" "No, no, don't leave!" "Help me!" "No!" "No!" " Get Hershel." " Help!" "Help!" "Help!" "Help me!" "Hershel!" "No!" "Help!" "Hershel." "Hershel." "The gunfire must've attracted the walkers." "Where's Rick?" "He ran across." "Well, hell, we can't go without him." "Rick!" " We have to go now." " No!" " I'm sorry, son." "We have to go." " No, no, don't leave me, please." " We have to go." " We can't." " He was just shooting at us!" " He's a kid." " Please help me." " This place is crawling with walkers!" "We can't leave him!" "The fence went clean through." "There's no way we can get the leg off in one piece." " Shut up or I will shoot you!" " That may be the answer." "We're not gonna get that leg off without tearing the muscle to shreds." "He certainly can't run." "He may bleed out." "Shut up." "I'm sorry." "Shut up." "Shut up." "Maybe we should put him down." "I don't wanna see any more killing, but this is cruel." "Can't we just take the leg off?" "That hatchet still in the car?" "No, no." "Don't cut my leg off, please." " Please, not my leg." " Will this cut through the bone?" "I'll have to sever the ligaments below the kneecap, out above the tibia." "He's going to lose his lower leg." " No, don't." "No." " When we get clear of here, we're gonna have to find some tinder, cauterize the wound so he doesn't bleed out." " All right, no choice." "Hurry up." " Oh, God." "Oh, God." "Hand me that stick." "Here." "Guys, walkers." " Shut up!" " Oh, my God." "Hurry up!" "Shut up." "Oh, God!" "They're everywhere." " Hershel, how we doing over there?" " I need more hands!" "Easy, easy." "No, don't cut my leg off, please." "Come on, we gotta go!" "I'm almost out of ammo!" "We don't have much time!" "Come on, we've gotta go!" "Can't hold them off!" "Hershel, do it now!" " Come on, Hershel!" " There is no time!" "Hershel, come on!" "Please don't leave me!" "Please!" "No!" "Don't leave me!" "Please!" "Please don't leave me!" " Are you all right?" " I'm fine." "You're not fine." "I saw the wreck." "Let me look at you." " What happened?" " Looked down at the map and hit a walker." "Next time stay put, you won't need a map." " Come on, I gotta get you back." " No, we gotta find Rick." "He's back." "They're all back." "They're all safe and sound." " Really?" " Yeah." "Oh, thank God." " What are you doing?" " God." " Keeping an eye on you." " Ain't you a peach?" "I'm not gonna let you pull away." "You've earned your place." "If you spent half your time minding your daughter's business instead of sticking your nose in everybody else's, she'd Still be alive!" "Go ahead." "Go ahead and what?" "I mean, just go!" "I don't want you here!" "You're a real piece of work, lady." "What, are you gonna make this about my daddy or some crap like that?" "Man, you know jack." "You're afraid." "You're afraid 'cause you're all alone." "You got no husband, no daughter." "You don't know what to do with yourself." "You ain't my problem!" "Sophia wasn't mine!" "All you had to do was keep an eye on her!" "Hmm." "Yeah." "Oh, my God, are you all right?" "What happened?" " I was in an accident." "I'm fine, I'm fine." " She was attacked." "I really am." "Where's Rick?" "They're not back?" "Where are they?" "Look, I had to get you back here." " You asshole." " Lon." " He's my husband." " Lori, I will go after him." "I will find him." "Hey!" "Now, look, first things first." "I gotta..." "I gotta look after you." "I gotta make sure the baby's all right, okay?" "You're having a baby?" "Why didn't you tell me?" "Come on." "Let's make sure you're all right." "Come on." "Thank you." "Hey." "I am so sorry that I left without telling you." "It's okay." "I wasn't scared." "When's Dad getting back?" "Let's hope soon." "I wanna be there when you tell him about the baby." "He already knows." "We were just trying to find the right time to tell you." "Is it a boy or a girl?" "Well, we won't know that until it's born." " Will I be able to feel it?" " Not for a while." "You must have a lot of questions, huh?" "We never had the talk." "I guess we forgot." "Don't look at me." "That's your father's job." "If the baby's a girl, can we name her Sophia?" "Hey, dude." "Hey, I'm sorry, bud." "Okay?" "I thought you knew." "Big brother Carl." "Pretty cool, huh?" "I say that's very cool." "You mind if I talk to your mom a sec?" "How about a little later after she's had some rest?" "Lori, I had to get you back here." "You wouldn't have come otherwise." "How about you..." "How about you just hear me out, please?" "It's okay." "Can you give me a minute?" "Thanks, bud." "Okay." "Lori, it was a lie." "It was one little white lie." "But I think that..." "I think you ought to be thinking about how lucky we are that your baby's safe." "You just can't stop lying, can you?" "My husband is back safe and sound." "My husband is dead in some hospital." "When are you gonna..." "When are you gonna stop throwing that in my face, huh?" "I thought that he was..." "The point here, Lor, is that you cannot keep running off like that." "What are you thinking about?" "I was thinking we needed Rick here to keep us safe." "Rick?" "I keep you safe." "Like you did with Otis?" "What happened that night?" "You haven't been the same since." "You wanna know what happened with Otis?" "What happened with Otis happened because I love you." "I love you and I love Carl." "I told Rick." "What?" "You told him what?" "Did you tell him that you thought you were a widow?" "That you were grieving and that the world was coming to an end?" "That you needed comforting?" "Did you tell him it was a mistake?" "Mmm-hmm." "You know, Lori, that ain't true." "What we had, it was real." " It was not." " It was a long time coming." " It was real, Lori." " It was not." "It was you and it was me and Carl, and it was real." "It was right." "Don't say it wasn't." "It wasn't." "Just think about what you felt, just for a second." "What you felt." "Everything falling apart all around us, but it..." "It was the one good thing." "And you know it's true." "How is she?" "Dehydrated." "I'll set up an IV." "Best I can do without Hershel." "Hey." "Can I get you anything?" "I just wish my dad was here." "She'll be okay." "You just need to be strong for her." "I was just reminding her about..." "Never mind." "No, no." "I'd love to hear." "My dad would die if he heard this." "My first summer back from college," "I drove home, dumped my stuff off, went straight out to the stable for a ride." "My family comes back from church and Beth grabs my things and starts unpacking my stuff upstairs." "That's sweet." "Yeah, until this one here starts rifling through my backpack." "She finds this little plastic container with these pink and green candies inside." "She didn't even know I was on the pill." "She was so freaked out by the idea of me and boys and sex, that she runs outside and chucks them in the duck pond." "And I ride up, I see this, I'm screaming." "She's crying and Shawn runs outside, thinks one of us is drowning." "Soon as he figures out what's going on, the jerk busts out laughing so loud that my horse rears up and gets mud all over the three of us." "My dad comes out, "What the heck is going on out here?"" "And she turns around, bats her eyelids and says," ""We're just swimming, Daddy."" "In her Sunday dress, all covered in snot and mud." "Rick and Glenn will get your dad back." "Glenn's a good guy." "Yeah." "He is." "Are you sure you wanna risk it?" "You might not make it back." "I'll be fine." "And with Shane at the helm, I wouldn't be too sure." "He's lost people before." "And he's had my back." "What are you insinuating?" "He doesn't want Rick back, or Hershel." "With them gone, he's got everything he wants and no one to tell him otherwise." "Shane has done more to keep this group alive than anybody," " including Rick." " You can't possibly believe that." "I do." "Guys." "Dad!" "You're okay." "Patricia, prepare the shed for surgery." " Are you hurt?" " No, but what happened to you?" " I was in a car accident." " Accident?" "How?" " I went looking for you." " Snuck out on her own." " I brought her back." " Are you crazy?" "You could've..." "Who the hell is that?" "That's Randall." "We couldn't just leave him behind." "He would've bled out, if he lived that long." "It's gotten bad in town." "What do we do with him?" "I repaired his calf muscle as best I can, but he'll probably have nerve damage." "Won't be on his feet for at least a week." "When he is, we give him a canteen, take him out to the main road, send him on his way." "Isn't that the same as leaving him for the walkers?" " He'll have a fighting chance." " Just gonna let him go?" "He knows where we are." "He was blindfolded the whole way here." "He's not a threat." "Not a threat." "How many of them were there?" "You killed three of their men, you took one of them hostage," " but they just ain't gonna come looking?" " They left him for dead." "No one is looking." "We should still post a guard." "He's out cold right now, will be for hours." "You know what?" "I'm gonna go get him some flowers and candy." "Look at this, folks!" "We back in fantasy land!" "We haven't even dealt with what you did at my barn yet." "Let me make this perfectly clear once and for all." "This is my farm." "I wanted you gone." "Rick talked me out of it, but that doesn't mean I have to like it." "So do us both a favor." "Keep your mouth shut." "Look, we're not gonna do anything about it today." "Let's just cool off." "Can I talk to you?" "What's going on with you?" "Your dad saved my life today, and Rick saved us both." "And I..." " I froze." " Well, you were being shot at." "I know, but..." "You don't have anything to prove." "All I've done, and this, okay?" "It's because of what you said." "That I love you?" "Yeah." "A bullet hit the wall behind me and I thought of you, losing me, hurting." "And I couldn't take it, so I hid to stay alive." "Glenn." "No, no, no, you don't get it." "Rick, your dad, they were counting on me, and I only thought of myself." "Has she eaten?" "I'll give her a sedative, stop her body from working too hard." "You were drinking." "That was the least of my worries." "You left and I didn't know what to do!" " Want me to take watch?" " Yeah." "Relieve T in a few hours." "I'm gonna take the graveyard." "And then what?" "We just send him on his merry way?" "According to Rick and Hershel." "If he finds his people and leads them here, we'll have a war on our hands." "You know you're preaching to the choir, girl." "You ever consider a lighter touch?" "Abandoning the search for Sophia, taking out the walkers in the barn, lying to Lori today." "Those were all the right calls." "It's your presentation that leaves something to be desired." "Dale send you?" "I see you pushing everyone away." "For what?" "They need you." "I'll always be the odd man out." "The same as you." " I've made my peace." " Have you?" "The way I see it, you and me, we're treated the same way." "Everyone's always trying to take the gun out of your hand." "These folks, they want to play house." "They wanna pretend that Rick and Hershel, they know what they're doing." "Let me tell you something, they bound to get us all killed." " Then we have to stop that." " They don't listen." "They're gonna give this kid a care package." "They're gonna send him on his way." "And you're right, that's gonna bring on a war or something worse, and We're just gonna..." "We're gonna sit here and wait for it." "But you and me, we're the only ones who see it coming." "I should've left with you when I had the chance." "Oh, man." "Thank you." " Little help." " Come here." "Ow!" "Ow!" "We're like a couple of old people." "We need to talk about Shane." "What's he done now?" "He thinks the baby's his." "No matter what, it's yours." "He'll accept that." "You're gonna have to make him." "He won't listen to me." "He's delusional and he's dangerous." "When I went looking for you, he came after me." "Well, of course he did." "And lied to me to get me back here, said you were already back." "Wha..." "You saw what he did at the barn." "He's threatened Dale and Hershel." "He's scaring people and he's scaring me." "And I think he killed Otis." "I think he left him behind and I think..." "I think he did it not just to save Carl, but because he loves me." "But you don't know that." "And he thinks that we're supposed to be together no matter what." "Those gunmen left that kid behind today." "I killed two people myself because of you, and Carl and the baby." "It was gonna be me and not them no matter what." "You killed the living to protect what's yours?" " That's right." " Shane thinks I'm his." "He thinks the baby's his." "And he says you can't protect us, that you're gonna get us killed." "He's dangerous, Rick, and he won't stop."
WASHINGTON—The Trump administration is preparing to initiate direct talks with Iran-backed Houthi forces in Yemen in an effort to end the four-year-old war, a conflict that has become a volatile front line in the conflict with Tehran, according to people familiar with the plans. The U.S. is looking to prod Saudi Arabia into taking part in secret talks in Oman with Houthi leaders in an effort to broker a cease-fire in Yemen, according to these people. The...
A model for the temporal organization of X- and Y-type receptive fields in the primate retina. A model is proposed for the temporal characteristics of X- and Y-type responses of ganglion cells in the primate retina. The main suggestions of the model are: (I) The X-type temporal response is determined primarily by the delay between center and surround contributions. (II) The Y-type response is generated in the inner plexiform layer by a derivative-like operation on the bipolar cell's input, followed by a rectification in the convergence of these inputs onto the Y-ganglion-cell. (III) The derivative-like operation is obtained by recurrent inhibition in the dyad synaptic structure. The X- and Y-type responses predicted by the model, for a variety of stimuli, were examined and compared with available electrophysiological recordings. Finally, certain predictions derived from the model are discussed.
var MyJsClass = module.exports = function() { if (this instanceof MyJsClass) { } else { return new MyJsClass(); } } MyJsClass.getClassName = function() { return "jvm/examples/jsclass/MyJsClass"; } MyJsClass.prototype.init = function(nick) { this.nick = nick; } MyJsClass.prototype.getName = function() { return this.nick; } MyJsClass.prototype.say = function(message) { console.log("This message from java <" + message + ">"); } MyJsClass.prototype.bye = function() { console.log(this.nick + ": bye!!!"); }
An evolutionary computing approach for parameter estimation investigation of a model for cholera. We consider the problem of using time-series data to inform a corresponding deterministic model and introduce the concept of genetic algorithms (GA) as a tool for parameter estimation, providing instructions for an implementation of the method that does not require access to special toolboxes or software. We give as an example a model for cholera, a disease for which there is much mechanistic uncertainty in the literature. We use GA to find parameter sets using available time-series data from the introduction of cholera in Haiti and we discuss the value of comparing multiple parameter sets with similar performances in describing the data.
Microsurgical aspects of the treatment of azoospermia. The BMFT Study Group for Microsurgery. Technical advances in microsurgery have produced a calculable success rate for reconstructive surgery in cases of obstructive azoospermia. Nevertheless, in standardized vasovasostomy and tubulovasostomy, the different outcomes for patency and pregnancy indicate that further comprehensive clinical and basic scientific studies are required to improve the results of surgery. The aspiration of epididymal and testicular spermatozoa in combination with intra-cytoplasmic sperm injection (ICSI) is one example of a fruitful integration of microsurgery into new areas of reproductive medicine. Where there is ejaculatory duct obstruction, the continuity with the posterior urethra can be restored by a transurethral operation.
YES, BUT HE ALSOWAS A PROPHET WHO KNEW THE SECRET TRUTHABOUT THE NATURE OF LIFE. THIS IS JUSTTOO MUCH... WE WANT TOREVEAL TO STAN THE GREAT SECRET OF LIFEBEHIND OUR CHURCH. THE SAFELY GUARDEDSCIENTOLOGY DOCTRINE. PLEASE, YOUR SON DESERVESTO BE ENLIGHTENED. STAN, DO YOUWANT TO HEAR THE GREAT SECRET DOCTRINE OF LIFE BEHIND SCIENTOLOGY ? SURE. ALRIGHT, GO AHEADAND TELL HIM. WOULD YOUEXCUSE US, PLEASE. THIS IS HIGHLY CLASSIFIEDCHURCH INFORMATION. AW, RATS ! USUALLY, TO HEARTHE SECRET DOCTRINE YOU HAVE TO BE IN THE CHURCHFOR SEVERAL YEARS, STAN. ARE YOU READYTO HEAR THE TRUTH ? I... I GUESS. YOU SEE, STAN. THERE IS A REASON FOR PEOPLEFEELING SAD AND DEPRESSED... AN ALIEN REASON. IT ALL BEGAN SEVENTY-FIVEMILLION YEARS AGO... BACK THEN, THERE WAS A GALACTICFEDERATION OF PLANETS, WHICH WAS RULED OVERBY THE EVIL LORD XENU ! HA HA HA HAAA ! XENU THOUGHT HIS GALAXYWAS OVERPOPULATED AND SO HE ROUNDED UPCOUNTLESS ALIENS FROM ALLDIFFERENT PLANETS... AND THEN HADTHOSE ALIENS FROZEN ! ZBAATAAA ! HA HA HA HAAAA ! THE FROZEN ALIEN BODIES WERE LOADED ONTOXENU'S GALACTIC CRUISERS, WHICH LOOKED LIKE DC-8s,EXCEPT WITH ROCKET ENGINES. THE CRUISERS THEN TOOKTHE FROZEN ALIEN BODIES TO OUR PLANET... EARTH. AND DUMPED THEM INTOTHE VOLCANOES OF HAWAII. THE ALIENS WERENO LONGER FROZEN THEY WERE DEAD. THE SOULS OF THOSE ALIENSHOWEVER, LIVED ON AND ALL FLOATED UPTOWARDS THE SKY... BUT, THE EVIL LORD XENUHAD PREPARED FOR THIS ! HA HA HA HAAAAA ! XENU DIDN'T WANTTHEIR SOULS TO RETURN, AND SO HE HAD BUILT GIANTSOUL CATCHERS IN THE SKY ! AAAAAGHGHGH !ZZZZZZBAAAAA ! THE SOULS WERE TAKEN TO A HUGESOUL BRAINWASHING FACILITY WHICH XENU HAD ALSOBUILT ON EARTH ! THERE THE SOULSWERE FORCED TO WATCH DAYS OF BRAINWASHING MATERIAL WHICH TRICKED THEM INTOBELIEVING A FALSE REALITY. XENU THEN RELEASEDTHE ALIEN SOULS, WHICH ROAMED THE EARTHAIMLESSLY IN A FOG OF CONFUSION. AT THE DAWN OF MAN, THE SOULS FINALLY FOUND BODIESWHICH THEY COULD GRAB ONTO. THEY ATTACHED THEMSELVESTO ALL MANKIND WHICH STILL TO THIS DAY,CAUSES ALL OF OUR FEARS, OUR CONFUSIONSAND OUR PROBLEMS. L. RON HUBBARDDID AN AMAZING THING, TELLING THE WORLDTHIS INCREDIBLE TRUTH. NOW ALL WE'REASKING YOU TO DO... IS PICK UPWHERE HE LEFT OFF. BUT I DON'T KNOWANY OF THIS STUFF ! NEITHER DID L. RONWHEN HE STARTED. HE SAID HE JUSTCLOSED HIS EYES AND WROTE DOWNWHATEVER CAME TO MIND. YOU CAN DO THE SAME,JUST LET IT FLOW. OKAY, I'LL TRY. I JUST WISH I COULDWRITE IN MY ROOM, BUT TOM CRUISE WON'TCOME OUT OF THE CLOSET. I KNOW, WE'VE SENTNICOLE KIDMAN UP THERE TO SEE IF SHE CAN HELP. TOM...TOM IT'S NICOLE. HI NICOLE. TOM, DON'T YOU THINK THISHAS GONE ON LONG ENOUGH ? IT'S TIME FOR YOU TOCOME OUT OF THE CLOSET.
Q: How to programmatically send SMS on the iPhone without "MFMessageComposeViewController "? I would like to send an SMS from an iPhone but MFMessageComposeViewController pops up the message,I would like to send the SMS when an event or notification occurs in the application.Is it possible through iOS SDK or are there any legitimate low level function which can be used to accomplish the same. A: It's not possible to send SMS messages programmatically through the iOS SDK. As you can imagine, if the SDK allowed this, it would open a huge can of worms in terms of developer abuse. If the SMS messages don't have to come from the user's phone number, you can take a look at the Twilio API (http://www.twilio.com/sms).
const { accounts, contract } = require('@openzeppelin/test-environment'); require('@openzeppelin/test-helpers'); const ContextMock = contract.fromArtifact('ContextMock'); const ContextMockCaller = contract.fromArtifact('ContextMockCaller'); const { shouldBehaveLikeRegularContext } = require('./Context.behavior'); describe('Context', function () { const [ sender ] = accounts; beforeEach(async function () { this.context = await ContextMock.new(); this.caller = await ContextMockCaller.new(); }); shouldBehaveLikeRegularContext(sender); });
How Car Loans Work I’m graduating soon, and I’m going to be on my own financially. One of the things I’m sure I’ll have to do pretty soon is buy a car, as I’ll be moving off campus and won’t necessarily have easy access to my new workplace. But I’m not sure I understand how car loans work. What determines the rates on those–it’s my credit, right? But how is my credit calculated? And should I even take out a car loan at all, or is taking on debt to buy a vehicle a bad idea? Experts, please help! Personal finance can seem complicated at times, but making the right decision is often easier than it may appear. Loans–including car loans–are good examples of things that often seem more complicated than they actually are. As with any other type of loan, the idea behind a car loan is that you are borrowing money that you will have to pay back with interest. The interest is what makes it worthwhile for the lender to let you have their cash for a while. But a car loan also has another dimension to it. You probably know that if you don’t pay your car loan off, the lender can repossess your vehicle. That’s actually a good thing for responsible borrowers, because it makes car loans something we call a “secured loan.” Secured loans have “collateral”–the car, in this case–that lenders can take if the borrower defaults. That lowers the risk for the lender, which translates to lower interest rates! You could still get an auto loan with bad credit through some lenders and dealers, say the consumer finance experts at Apply & Buy. A low credit score, or a lack of credit, isn’t always a barrier to getting a loan. But should you get a loan at all? You’ll find advice from all kinds of perspectives, but most experts agree that it’s not a bad idea to take out a car loan, provided that you are sensible about your budget. Not all loans are healthy–payday loans, for instance, are dangerous–but car loans are usually not predatory. There are pros and cons to car loans, but if your payments are affordable and your loan allows you to get a car that you need at the beginning of your career, it’s alright to take on a conservative amount of debt. Just remember to follow the laws of the road and drive safely as getting into an accident can cause your insurance premiums to rise and be a detriment to your finances. If you do find yourself in a serious accident, be sure to seek out the help of a motor vehicle accident attorney as you may be able to mitigate some of the costs and even have the other party held responsible for repairs if it can be proven that the accident was not your fault.
The long-term goal is to gain a better understanding of the biological roles of gamma (immune) interferon (IFN-gamma) and of a functionally related class of cytotoxic proteins, termed "cytotoxins". Cytotoxins include lymphotoxin (LT), monocyte/macrophage-derived cytotoxin(s) (MCT) and tumor necrosis factor. Our broad working hypothesis is that IFN-gamma and cytotoxins mutually amplify their actions and that this synergism is important in inhibiting tumor cell growth and in limiting the spread of viruses and other intracellular infectious agents. The first specific aim is to gain a better understanding of the nature, multitude and mutual relationships of the various cytotoxin proteins produced by human lymphocytes and monocytes/macrophages. To answer these questions we shall perfect the methods of production of lymphocyte-derived LT and monocyte/macrophage-derived MCT from human cells, complete the purification of these proteins and produce specific polyclonal and monoclonal antibodies against them. The second specific aim is to elucidate the mechanism by which IFN-gamma produces enhanced monocyte cytotoxicity for tumor cells and to determine the possible role of cytotoxins in this process. This part of the project is based mainly on the recently established fact that IFN-gamma is uniquely active as a modulator of monocyte/macrophage functions, including activation of monocytes for tumor cell cytotoxicity. The third specific aim is to advance our understanding of the mechanisms of action of LT and MCT and of their synergism with IFN-gamma. The study of these questions will rely mainly on the analysis of the role of cellular receptors for cytotoxins and IFN-gamma and of the fate of cytotoxins and IFN-gamma after their binding to target cells. The proposed studies are likely to provide biologically relevant and medically significant information on host defenses in malignancies and virus infections.
[Obstructive azoospermia. Instrumental diagnosis: echography and endoscopy]. Obstructive disorders of seminal tract are mainly distinguished in Proximal and Distal Obstructive Syndrome, following typical seminal pattern. Fine localization of obstruction is very important for prognostic and therapeutic evaluation. In Proximal Obstruction the role of echography and endoscopy is today poorly defined and usefull. In Distal Obstruction a preeminent role is recognised to transrectal ultrasound and its mini-invasive applications: biopsy, evacuative puncture, direct contrastography of obstructed seminal way. At this regard is reported a case of dysmorphic congenital obstruction documented with transrectal ultrasound and contrastography. Diagnostic endoscopic indications mainly refer to therapeutic procedures.
In important aspect of semiconductor structures, such as integrated circuits, is the ability to interconnect various components both on the same layer and in different layers of the integrated circuit. As integrated circuits and other semiconductor structures get smaller, the size of the relevant interconnects also decreases. Conventional interconnect deposition techniques include damascene processes of patterning the interconnect within another structure, such as a dielectric. The damascene process has been used for hundreds of years to produce jewelry and various other ornamental objects. However, with the continued reduction of integrated circuit size it becomes more difficult to utilize conventional techniques for forming interconnects and vertical interconnect accesses (“vias”), especially when high-aspect ratio structures are involved. This significantly limits the ability to continue using conventional interconnect deposition techniques.
Q: Passed anonymous callback function detected as undefined The next() function in the code below passes an anonymous function to the position() function. The position() function positions the bubble(sort of a lightbox) in the DOM and at the end of the execution, it calls the anonymous function, which in turn, shows the bubble. Any idea why my anonymous function is undefined? ;(function ($) { Bubble = { init: function() { $('.bubble:not(:first)').hide(); $(document).on('click', '.next', Bubble.next); }, next: function() { $('.bubble').next().addClass('current'); Bubble.position(function(){ $('.current').fadeIn(); }); }, position: function(callback) { $('.current').css({ /**/ }); callback(); // Console shows that 'callback' is undefined } } $(function() { Bubble.init(); }); })(jQuery); A: try this. Might b this solves your problem. if($.isFunction(callback)){ callback.apply(); }
Sydney: New Sydney FC striker Adam Le Fondre admits being surprised by the standard of the A-League. Le Fondre has the unenviable task of filling the record-breaking boots of Bobo for the Sky Blues this season after joining the club on a multi-year deal. Adam Le Fondre scores from the spot for Sydney FC during the FFA Cup semi-final against Western Sydney Wanderers. Credit:AAP Based on his trial form, the former Premier League forward has quickly found his footing for the perennial contenders with two goals in as many games. "I've been really impressed by the quality of the boys that create chances," Le Fondre said ahead of their season-opener against Adelaide on Friday.
In this age of increased air pollution, the removal of chemicals from the air we breathe is a concern of everyone. Gas phase filtration is commonly accomplished using activated carbon manufactured in various ways. One approach comprises using a carbon/adhesive slurry to glue the carbon to the substrate. The adhesive decreases carbon performance by forming a film on its surface. A second approach involves carbonizing an organic based web by heating, followed by carbon activation. This material is high cost and has relatively low adsorption capacity. A third approach involves forming a slurry of carbon powders and fibers into sheets by a process analogous to a wet papermaking process. This material is medium-to-high cost, and has an undesirable high pressure drop. Moreover, chemically impregnated carbon particles cannot be efficiently used in conjunction with an aqueous process, as the aqueous nature of the process either washes away the chemical used to impregnate the carbon, or reacts undesirably with the impregnating chemical rendering it useless. In general, however, filter materials which do not incorporate chemically impregnated adsorbents perform far less effectively than those which do include chemically impregnated adsorbents. None of these approaches fully achieve the desired properties which provide a cost effective, high efficiency, low pressure drop, adsorptive composite.
Novel roles of complement in renal diseases and their therapeutic consequences. The complement system functions as a part of the innate immune system. Inappropriate activation of the complement pathways has a deleterious effect on kidneys. Recent advances in complement research have provided new insights into the pathogenesis of glomerular and tubulointerstitial injury associated with complement activation. A new disease entity termed 'C3 glomerulopathy' has recently been proposed and is characterized by isolated C3 deposition in glomeruli without positive staining for immunoglobulins. Genetic and functional studies have demonstrated that several different mutations and disease variants, as well as the generation of autoantibodies, are potentially associated with its pathogenesis. The data from comprehensive analyses suggest that complement dysregulation can also be associated with hemolytic uremic syndrome and more common glomerular diseases, such as IgA nephropathy and diabetic kidney disease. In addition, animal studies utilizing genetically modified mice have begun to elucidate the molecular pathomechanisms associated with the complement system. From a diagnostic point of view, a noninvasive, MRI-based method for detecting C3 has recently been developed to serve as a novel tool for diagnosing complement-mediated kidney diseases. While novel therapeutic tools related to complement regulation are emerging, studies evaluating the precise roles of the complement system in kidney diseases will still be useful for developing new therapeutic approaches.

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