text
stringlengths 16
69.9k
|
|---|
##
## Socket Mode
##
#
# Require this file if you wish to run your server and/or client RPC
# with the raw socket handlers. This is the default run mode for bin/rpc_server.
#
# To run with rpc_server either omit any mode switches, or explicitly pass `socket`:
#
# rpc_server myapp.rb
# rpc_server --socket myapp.rb
#
# To run for client-side only override the require in your Gemfile:
#
# gem 'protobuf', :require => 'protobuf/socket'
#
require 'protobuf'
require 'protobuf/rpc/servers/socket/server'
require 'protobuf/rpc/connectors/socket'
::Protobuf.connector_type_class = ::Protobuf::Rpc::Connectors::Socket
|
FALSTAFF — My whole charge consists of slaves
as ragged as Lazarus, and such as indeed were never soldiers, but
discarded serving-men and revolted tapsters. No eye hath seen such
scarecrows. Nay and the villains march wide between the legs, as
if they had fetters on; for, indeed, I had the most of them out
of prison. — Shakespeare, slightly varied.
|
An explanation of how and why healthy eating and regular exercise can reduce the risk of cancer. There is plenty of evidence now to support this. The article contains a number of links to resource sheets and brochures on the subjects.
|
#ifndef FWCore_Utilities_TypeID_h
#define FWCore_Utilities_TypeID_h
/*----------------------------------------------------------------------
TypeID: A unique identifier for a C++ type.
The identifier is unique within an entire program, but can not be
persisted across invocations of the program.
----------------------------------------------------------------------*/
#include <iosfwd>
#include <typeinfo>
#include <string>
#include "FWCore/Utilities/interface/TypeIDBase.h"
namespace edm {
bool stripTemplate(std::string& theName);
std::string stripNamespace(std::string const& theName);
class TypeID : private TypeIDBase {
public:
TypeID() : TypeIDBase() {}
explicit TypeID(std::type_info const& t) : TypeIDBase(t) {}
template <typename T>
explicit TypeID(T const& t) : TypeIDBase(typeid(t)) {}
// Print out the name of the type, using the dictionary class name.
void print(std::ostream& os) const;
std::string const& className() const;
std::string userClassName() const;
std::string friendlyClassName() const;
explicit operator bool() const;
using TypeIDBase::name;
bool operator<(TypeID const& b) const { return this->TypeIDBase::operator<(b); }
bool operator==(TypeID const& b) const { return this->TypeIDBase::operator==(b); }
using TypeIDBase::typeInfo;
private:
};
inline bool operator>(TypeID const& a, TypeID const& b) { return b < a; }
inline bool operator!=(TypeID const& a, TypeID const& b) { return !(a == b); }
std::ostream& operator<<(std::ostream& os, TypeID const& id);
} // namespace edm
#endif
|
Overall
Vision Vision
Originality Originality
Technique Technique
Impact Impact
Very few photographies are able to come close to perfection and this shot is among those.You are immediately captured into the scene as soon as you start looking at this photo. The yellow tent first, then this dark blue infinite sky and of course the summits. Finally, the deep, cold snow into which the photographer will have to spend the night... The mountain feeling is everywhere here and this photo is the perfect combination of an extremely aesthetic image and a fascinating story telling.Technically, the mastery of the exposure is right on : the tent is not burned out, the sky colour and the stars are well revealed and the shadows are not too dense. To finish, the composition has of course been calculated with a lot of care : the position of the tent, the right surface for the sky and this nice diagonal rising from the left to the right side.All in one, a captivating and absolutely superb night / mountaineering shot. All my congratulations to Xavier Jamonet for this masterpiece !
|
"It's as loud five minutes before the game, as it is in the fourth quarter as it is in the second quarter," curry said. "As you go around in different arenas, you are even more impressed with how loud it is and how much we feed off it."
|
Conventional hair dryers, dryers for clothing, dehumidifiers and air conditioners normally include a source of heat applied to the moving ambient air. Much of the ambient air has a load of water therein normally requiring heat energy at the same time as the air is warmed. Often times the use of the heated air, particularly in hair dryers, provides for the delivery of drying air through a bonnet which is uncomfortably warm to the user.
Various efforts in the prior art have been made to predry air for various purposes.
|
Mamata Banerjee has announced a series of rallies to protest the amended Citizenship Act.
Individual state governments are not empowered to halt the implementation of a law that comes under the centre's mandate, sources in the Union Home Ministry claimed today, amid a rising chorus of opposition to the amended Citizenship Act.
"States do not have the power to say 'no' to a central law enacted under the Union List of the Constitution's 7th Schedule," a top ministry official said, adding that the granting of citizenship is a central prerogative.
Several opposition-led states -- including West Bengal, Kerala, Madhya Pradesh, Chhattisgarh and Punjab -- have said that they will not allow the implementation of the amended Citizenship Act in their territories. They have termed the law -- which provides for expediting citizenship for migrants from three neighbouring countries so long as they are not Muslims -- as "discriminatory" and "unconstitutional".
The bill became a law late on Thursday night, after it received President Ram Nath Kovind's assent, amid violent protests in the Northeast. Two people were killed in police firing in Assam's Guwahati earlier that day.
West Bengal Chief Minister Mamata Banerjee -- one of the most vocal critics of the law -- has warned that she will not allow its implementation in her state "under any circumstances", and announced a series of rallies against it. "We will not allow the Citizenship Act in Bengal even though it has been passed in the parliament," she said today, accusing the centre of trying to force an "unconstitutional" law on non-BJP states.
"The Citizenship Act will divide India. As long as we are in power, not a single person in the state will have to leave the country," she said.
Kerala Chief Minister Pinarayi Vijayan claimed that his state has no place for an "unconstitutional law" that discriminates against people from a certain community. "The Constitution of India guarantees the right to citizenship for all Indians, irrespective of their religion, caste, language, culture gender or profession. This very right is being made void by this law. A move to decide citizenship on the basis of religion amounts to rejecting the Constitution," he said.
Punjab Chief Minister Amarinder Singh said he will block attempts to implement the law through his party's majority in the state assembly. "This law is of a very divisive nature. Any legislation that seeks to divide the people of the country on religious lines is illegal and unethical," Mr Singh said.
|
namespace BRG.Entities
{
using System.Collections.Generic;
/// <summary>
/// 过滤规则集合
/// </summary>
public class FilterRuleCollection : List<FilterRule>
{
}
}
|
Gaming machines, such as slot machines, video poker machines and the like, have been a cornerstone of the gaming industry for several years. Generally, the popularity of such machines with players is dependent on the likelihood (or perceived likelihood) of winning money at the machine and the intrinsic entertainment value of the machine relative to other available gaming options. Where the available gaming options include a number of competing machines and the expectation of winning at each machine is roughly the same (or believed to be the same), players are likely to be attracted to the most entertaining and exciting machines. Shrewd operators consequently strive to employ the most entertaining and exciting machines, features, and enhancements available because such machines attract frequent play and hence increase profitability to the operator. Therefore, there is a continuing need for gaming machine manufacturers to continuously develop new games and improved gaming enhancements that will attract frequent play through enhanced entertainment value to the player.
One way that players may experience a heightened entertainment level while playing the wagering game is when the player senses that he or she has a better chance of achieving a winning outcome. In some wagering games, there are symbol arrays that are displayed to the player and that provide the multiple opportunities for winning outcomes. The present invention is directed to a wagering game having multiple symbol arrays, wherein one of the symbol arrays triggers the placement of symbols in the other symbol array in a manner that provides the player with a heightened entertainment level because the player perceives that he or she has a better opportunity for achieving a winning outcome.
|
Artificial
Intelligence has already become an essential part of our lives. Several sectors
like Politics, Media, and Engineering, etc. are capitalizing all of the
capacity of Artificial Intelligence. Hence, we are consuming the services of AI
in known or unknown ways.
Related Articles
Humans
created Artificial Intelligence for us to imagine a healthy, secure, connected
and creative future ahead. Mechanical Engineering plays a catalyst in the above
process of Imagination. In today’s era, education courses are helping us to create
people who can bring the distance of Humans and Machines closer. Which can help
create new products, systems, and avenues.
Let
us start from the basic,
What is Artificial Intelligence?
Artificial
Intelligence, well-spoken as A.I is a unit of computer science that works
towards creating and building smart appliances/machines which are capable of
doing similar or more amount of work than human tendency. Work that requires
human intelligence but can be done by Computer Science. A. I simulate and emulate
a human’s behavioural pattern through machines.
Mechanical Engineering?
Mechanical
Engineering is a branch of engineering dealing with Design, construction and
machines. Within this, a significant area which is related to Artificial
Intelligence is Mechanical Design.
Mechanical
Design comes to be a sub-set for Mechanical Engineering.
In
Mechanical Engineering Design, we can see the way toward concocting a part, framework
or stream to meet desired/needed need. Here, we can see the amalgamation of Science
and mathematics. Mechanical Design is a process to design the required
component, system, or process, which is necessary to meet the final result.
Mechanical Engineering – Mechanical Design and its relation with A.I is majorly
used by a Product Design Company.
Artificial Intelligence and Mechanical Engineering.
The
sector of Mechanical Engineering is the primary consumer of Artificial
Intelligence as a technology. It is more than any other industry; it is
consumed the most in Mechanical designs or engineering works. Sections of
Mechanical Engineering like Robotics, Automation, or sensor technology, uses
Artificial Intelligence as a technology. So it is easy to say that Mechanical Engineering
disseminates the application and use of AI in the eco-system.
Benefits of AI for Mechanical Engineering
There
are different areas where AI impacts the Mechanical Engineering process. The
idea behind the work of AI remains the same. It performs activities without
humans yet with increased tendency as compared to humans. It is prioritizing
the automated part of work, where we feed the computer with data, and as per
the command, the machine/process continues its function.
We
can feel the impact of AI in different areas, such as:
Manufacturing
Many
processes in the manufacturing industry require Mechanical Engineering to be
done with components, products, processes, etc. Artificial Intelligence is
currently used in similar processes of Mechanical Engineering. Whether in
Components, Products, or Processes. It is making sure about its presence being
felt. There are many other processes and technologies which are becoming easy –
fast and efficient with the help of Artificial Intelligence. Machine’s which
can do more work than human tendency and that too with least effort of humans
into it is the main goal here. When the above objective is achieved or worked
upon, it will send serious implications to different areas of the sector. (And
at some places, connections have already started affecting the scenarios)
That’s
what AI is impacting in the current era for the manufacturing industry. People
of the sector are also scared off them losing the jobs.
Mechanical Design
Whenever
we start the process of building a component/product/flow, the first step of it
would be of Mechanical Design. Different sectors of services are provided
through mechanical Design. To list the few as; Product Design, Machine Design,
Mechanical Component Design, Tooling and Fixture Development, Mold Design,
Casting Design. All are coming under the umbrella for Mechanical Design
Services. A. I. can majorly impact Product Design Services when it comes to
designing the concept, examining the product, and also during the manufacturing
of the product.
Big Data Storage and Usage through IT.
Data
has proved its presence everywhere. Even the processes and function of
Mechanical engineering requires the usage and storage of Data. When it comes to
mechanical engineering, the primary area where Data is needed the most is
machine learning. Yet another segment of mechanical engineering. Machine
learning has changed the perception of the potential of mechanical engineering.
It provides better efficiency/flexibility and quality of systems with the help
of data, resulting in the improvement of processes and systems in mechanical
engineering. It is one of the critical drivers of development for mechanical
engineering.
Coming
back to the discussion of AI’s impact, Artificial Intelligence has a
significant role in the increasing trend of Machine Learning. A. I has its
comfort zone when it comes to relying on Huge Data and Large Algorithmic
learnings. Machine learning, as discussed earlier, is dependent mostly on the
constant generation of data and its analysis. A. I learn through those large
sets of data and various commands that engineers might have to give in the
first place.
There are a few other ways where Artificial Intelligence does help during the process of Mechanical Engineering. Such as,
Stress Estimation of 3D Structures: Estimating the amount of stress while designing and manufacturing 3D structures.
Material Evaluation for different Services: Evaluating materials, its strength – durability – quality and helping in a more exceptional manufacturing process.
Structure Generation: While Generating a Structure, AI can help through its algorithms and data storage. It is making the process efficient and transparent.
As
we discussed, the Impact of AI on mechanical engineering. There are both sides
available to Artificial Intelligence: Good and Bad.
The Good Ones
A. I. can create a negligible amount of error, required that the programming is done in the best possible way. Compared to A. I, Humans have a probability of creating more errors in the work.
Compared to Human Speed, it is much faster w.r.t. Work.
A. I. lessens the amount of risk attached to the functioning and decision-making process. Through its algorithms and data, it is created to choose only the best possible result.
The Bad Ones
AI reduces the risk attached to work through its attributes of data and algorithms. But the same process eradicates the Human element attached to the entire process. Resulting in an impact on Moral of the employees.
AI lacks creativity.
The judgment process of AI is not dynamic, i.e., according to situations. It might not give the best possible output in a condition of Natural Calamity, Disaster, or any on-ground damage.
Conclusion
Artificial
Intelligence isn’t a long listed dream anymore. More and more industries are
taking advantage of it and providing some fantastic results that can help human
eco-system. Yes, AI might affect an industry’s HR by eradicating the least
essential employee. Yes, it might kill the human element attached to the
process. Yet, against all of it, it is helping our generation to imagine an
entirely new world by impacting the different fields.
It
is a Superpower. If it is not used with maturity and responsibility, it has all
the possibility to backfire us. Remember the Avengers?
The post Artificial Intelligence and its Alliance with Mechanical Engineering appeared first on Blog Tesla Outsourcing Services.
|
AustCham's Submission to the Hong Kong SAR
Hong
Kong: The Australian Chamber of
Commerce in Hong Kong and Macau submitted its recommendations to the Hong Kong SAR ahead of the Chief Executive's first policy address due
to take place next week.
In this submission, AustCham calls for the HKSAR to continue
to preserve Hong Kong's place as a major international city by:
Preserving the rule of law, independence of the judiciary, freedom of speech and free flow of capital;
Harnessing Hong Kong’s inherent dynamism and capacity to innovate by laying fertile ground for start-ups and embracing digital technology; “walk the talk” in terms of ensuring that the bureaucracy acts as a role model establishing technological and digital best practices;
Continuingto address entrenched bank account opening and administration difficulties impacting the ability of our members to do business;
Providing tax incentives and certainty for corporations through a proposed regional headquarter tax concessions and Group Tax loss relief, among other initiatives;
Stepping up critically needed actions to address Hong Kong ‘s impending ageing crisis and seek to mandate raising the retirement age across the board.
AustCham also fully supports the
Hong Kong Government’s commitment to Free Trade Agreement (FTA) negotiations
with Australia, noting the significance of the territory’s recent conclusion of
talks with ASEAN on an FTA.
|
package dev.environment.listener;
import dev.environment.bean.EnvironmentBean;
import dev.environment.bean.ModuleBean;
/**
* detail: 模块环境改变触发事件
* @author Ttt
*/
public interface OnEnvironmentChangeListener {
/**
* 模块环境发生变化时触发
* @param module 环境发生变化的模块
* @param oldEnvironment 该模块的旧环境
* @param newEnvironment 该模块的最新环境
*/
void onEnvironmentChanged(ModuleBean module, EnvironmentBean oldEnvironment, EnvironmentBean newEnvironment);
}
|
French Interior Minister Claude Gueant, who also holds the immigration portfolio, caused political uproar by claiming that not all civilisations are equal, with some more advanced than others. "Contrary to what the left's relativist ideology says, for us all civilisations are not of equal value," Gueant on Saturday told a conference in the French parliament building, but closed to the media. "Those which defend humanity seem to us to be more advanced than those that do not," he argued in his speech at a meeting organised by a right-wing students group. - AFP
Why would all civilizations be equal? They evolved separately. What is this universal standard we might speak of, whether equality or a superiority? Adaptations vary. And why is this so demonized?
|
Correct shielding used on original brake lines for OEM restorers who want exact originality. Includes enough footage to allow you to replace or install shields on your original or replacement brake or fuel lines.
The PROP-BLOCK is a precision-machined combination distribution block and adjustable proportioning valve in one. The valve connects to the master cylinder and distributes brake fluid to all four wheels, while the adjustable...
Wilwood's stainless steel braided flexline set is manufactured to high quality standards. This premium grade flexline set has been designed for universal applications. The flexline set is required to complete the installation...
The PROP-BLOCK is a precision-machined combination distribution block and adjustable proportioning valve in one. The valve connects to the master cylinder and distributes brake fluid to all four wheels, while the adjustable...
This new line fastening system will keep your metal lines secure and look great while doing it! Once fastened down with the included hardware, your lines will snap in and out of these clamps for a clean and simple...
This new line fastening system will keep your metal lines secure and look great while doing it! Once fastened down with the included hardware, your lines will snap in and out of these clamps for a clean and simple...
This new line fastening system will keep your metal lines secure and look great while doing it! Once fastened down with the included hardware, your lines will snap in and out of these clamps for a clean and simple...
|
The plumber has been (you can't fault him for promptness) and checked the system; the electric power to the off-peak immersion has failed. Fuck knows where, but now it's an electrical issue, so I need to get a bloody electrician in. Knowing Eurolet, this could take further weeks.
|
Labour’s woke London luvvies IGNORED voters’ real concerns, says DEHENNA DAVISON
Last December's General Election was historic. There's no other way to put it. In my...
|
Vincent is a short tempered orphan, blessed with a super-human strength and living on the streets of the Ryuuga Ghettos.
One fateful day, he is confronted by a man more powerful than himself and recruited into the ranks of GRAVE; a secret anti-terrorist organisation who's members also possess strange abilities.
Situations become more complicated when an entity known as the Wrath is awakened and enters Vincent's body. Now having to come to terms with his new and deadly powers, Vincent is thrust head first into a world he never knew existed.
However when an ancient, cannibalistic demon surfaces from the shadows of history and leads an army on the world, it falls to the members of GRAVE to stop them and save the world from total annihilation.
Armed with a power that had been exiled for a thousand years, can Vincent be the key to the world's salvation or its demise?
|
Q:
error TS2339: Property 'log' does not exist on type '{ new (): Console; prototype: Console; }'
class helloworld
{
constructor(public message: string){}
}
var hello = new helloworld('hello vishal');
Console.log(hello.message);
I am getting this error at Console.log statement
you can see the error clearly in the image i posted below
A:
You have typo in your script. JavaScript is Case sensitive. Enter:
console.log(hello.message);
Instead Console.log(hello.message);
|
Do video game demos hurt sales of a game?
Something i was thinking about recently. I notice that almost all the times I download a demo for a game I end up never buying the actual game. It's not because the demos are bad but either the demo didn't sell me enough on the game or was satisfied with the demo to not need to buy the full version.
No I'm pretty sure they help. More times than not, the demo encourages more people to buy the game than it does deter people from buying it. I don't have any concrete stats on this but the mere fact that companies still put out demos makes me think that they work somewhat.
I find myself borderline on games a lot and I want a demo that I can play to get a feel for the game and see how well it will run on my pc. I have passed up a lot of games because I was borderline. I have bought many games that I was unsure about because the demo wow'd me.
If a demo satisfies me on the game or doesn't impress me... it's not the fault of it being a demo... it's the fault of the game being uninteresting to me. If I had bought the game for any reasonable amount of money and hated it, I'm pretty likely to never buy anything from that developer again. If I play a demo and it's just "meh" I will often continue to check out their stuff because I remember playing it. I also think it's a sign that the company stands behind their game that they are willing to let you sample it and that suggests a stronger title and a better developer.
So overall I think demos are a good thing and probably help sales of games. If they didn't, I would wager that they would have gone by the wayside long ago as we have had game demos around for decades now.
That's kind of a loaded question. It will hurt the sale of games that suck... but if you a play the demo for a well written (and well developed) game there's no way it could hurt sales. If anything, it would boost sales.
Depends on the game. If I play a demo that I have fun with, I usually buy the actual game. If I don't like the demo, I usually don't buy the game. I honestly think it depends on how the demo is set up.
|
In spray painting and the like, it is conventional to provide a mask that comprises a body adapted to fit over the mouth and nose of the wearer and be held in position by straps. Such an arrangement includes one or more inlet valves and associated filters through which the wearer inhales and an outlet valve through which the wearer exhales.
Where the environment is very contaminated, it is common that there be provided a pair of filters in series at the inlet valves, a cotton or cellulose filter to filter out particles and an activated charcoal filter to filter out solvent vapors. Such filters need to be replaced frequently. As a result, the use of such masks is expensive.
Another problem with standard type mask arrangements is that they are unsatisfactory for the wearer who has heavy facial hair because of the inability of the mask to seal around the face or for persons having differently shaped faces.
Among the objectives of the present invention are to provide an arrangement for conversion of the conventional safety masks for connection to a source of clean air; which can be readily adapted to conventional safety masks; which is low in cost; which obviates the need for a particle filter; which can be adapted to various types of safety masks; and which can be used in an environment of highly toxic paints.
In accordance with the invention, a cap is adapted to be positioned over the conventional filter and is interconnected to the filter. The cap has an opening in a wall thereof, and is connected by a tube to a valve supported by the body of the wearer. The valve includes an inlet for connection to a source of clean air, a first outlet to the tube connected to the opening in the mask and a second outlet for connection to a paint spray gun.
|
Q:
Better practices for catching code mistakes with Ember.js (specifically, messed up variable names)
In Ember.js, we use Ember's own object variants which recommend/necessitate using this.get and this.set in order to access object attributes.
I (mostly) understand why this is done, and appreciate the consistency and flexibility it adds to the Ember programming experience, but I do feel that I lose out on my IDE's sanity checking.
With Jetbrain products (or any good IDE w/ deep analysis and completion) I can usually rely on symbol suggestions to make sure I'm choosing the correct variable name. Entering in strings with ember relies on me to get the name right, and I'm a fallible human.
I have a few thoughts regarding possible solutions.
Some IDE plugin which does static analysis to suggest the correct string to use
An ES6 or alternative transpired language which accesses members the ember way by default
Some way of automatically establishing string constants where I need them
Some ember debugging setting which at least throws warnings if I try to get a variable which hasn't been defined.
I would also find it useful to throw warnings if ember catches me trying to set an attribute to undefined.
Hopefully, someone will tell me that one of these solutions exists, something better has been thought of, or my problem isn't really a problem.
(An example to illustrate my problem:)
In the following snippet
const email = this.get('email');
const newInvitation = this.store.createRecord('invitation', {email: email});
I am trying to get the attribute email but the real attribute I meant to get was called emailAddress. When I create the record, I do so with an undefined email field which isn't caught until later in the code.
It wasn't terrible to debug, but if I have to manually sift through every line of code every time I misspell something, I'm going to waste a lot of time and be a sad debugging-boy. Help!
A:
Currently we don't have a good solution for this. However the future looks bright!
Currently there is a lot of work going on in the ember-typings repository to build a typescript definition that will allow the typescript language server to give you that completion. This will give you completions for things like this.get('foo') but not for things like this.get('foo.bar') in near future.
Also I've build this, which will allow you to omit .get and .set on browsers that support the proxy object. However this is more a proof-of-concept then something you should use in production!
If you just want debug messages if you access a property thats null you can use unknownProperty:
unknownProperty(key) {
console.log('access to unknown property');
}
However I sometimes its required to access an unknown property for code like this:
if(!obj.get('foo')) {
obj.set('foo', 'bar');
}
So overall I would recommend you to try out typescript, because thats probably the solution that will give you a good developer experience soon and good support from the community as well. Interesting is also the ES classes RFC, that shows, that ember goes toward standard ES classes and at some point we won't .set and .get at all.
Also glimmer integration is going forward, and inside a glimmer component you won't need .set and .get.
Also I don't recommend you ember script. I tried it out, but there is basically no-one using it, and no support at all.
|
I am sorry that it's been so long since I've talked to you. After a long time with the Tales of Ubernorden, I've decided to take a little break from them. But I have not been resting on my laruels*. Instead, I've been working on a brand new story. This is a Science Fiction story about a space born humanity living and working in a galaxy that hates and fears them, and not entirely without reason.
I came up with the story a about a month ago. I liked it enough that I decided to start writing it down. But obviously I couldn't do that and Tales, at the same time. So for now, I'm going to work on that. But don't worry. Tales of Ubernorden is still a world I wish to return to at some point in the future.
If you would like to get a look at this new world you can see it here.
|
Increased processor demands continue to drive advances in central processing units (CPUs), bandwidth and associated memory devices. A CPU typically includes a die, or microchips, which contain multiple processing units, communications hardware, and a local networking or communications bus. The core logic chipsets (cores) are the components that make up the processor die. The cores comprise the central processing logic of a computing system. A system's core logic typically includes a controller for handling memory functions, a cache for storing instructions, the logic for bus interfaces, and the functions of data paths. A single die can contain hundreds of processor cores. In increasing the number of cores, computer performance also increases, as does the need for more memory. For efficiency considerations, the memory-to-processor core ratio must stay relatively constant. That is, as more processors are added, memory must be proportionally added.
The need for higher memory to processor-core ratios is further driven by advances in virtualization. Virtualization makes it possible to run multiple operating systems and multiple applications on the same computer at the same time, increasing the utilization and flexibility of hardware. In one respect, virtualization allows the transformation of hardware into software, including the CPU, RAM, hard disk and network controller, to create a fully functional virtual machine that can run its own operating system and applications just like a physical computer. Virtualization is advantageous because it allows for server consolidation and increased processor accessibility. And thus, virtualization is driving the need for even higher memory to processor-core ratios, and higher memory capacity on servers.
The increased processing afforded by virtualization requires the addition of memory to maintain the required ratio. For speed considerations, the preferred way to add memory is to attach main memory directly to the CPU. Performance is increased with data being stored directly in main memory, as opposed to slower, remote memory, e.g., memory on a disk. However, attaching memory directly to the CPU typically imposes a limitation on the total amount of available memory. Attached memory may be inadequate for applications requiring larger memory capacities.
Caching is commonly used to speed memory processes. A cache memory is smaller, faster and typically more expensive than main memory. When a CPU requests data that resides in main memory, the processing system transmits the requested data to the processor and also may store the data in a cache memory. When the processor issues a subsequent request for the same data, the processing system first checks cache memory. If requested data resides in the cache, the system gets a cache “hit” and delivers the data to the processor from the cache. If the data is not resident in the cache, a cache “miss” occurs, and the system retrieves the data from main memory. Frequently utilized data thus is retrieved more rapidly than less frequently requested data, and overall data access latency, i.e. time between a request for data and delivery of the data, is reduced.
In associative mapping, instead of hard-allocating cache lines to particular memory locations, it is possible to design the cache so that any line can store the contents of any memory location. A cache line is the smallest unit of memory than can be transferred between the main memory and the cache. Associativity improves performance by, in part, enabling multiple concurrent accesses to portions of memory.
Relatively large amounts of bandwidth are needed to support associativity, however. On some processor memory architectures, for instance, the x86, there is not enough memory bandwidth (the amount of data that can be carried from one point to another in a given time period) to support a cache with associativity. The inability to support cache access with associativity relegates manufacturers to using other, less efficient forms of memory access and lower performance.
Consequently, what is needed is an improved manner of managing memory in a system comprising a processor with directly attached memory.
|
Insulin-dependent diabetes mellitus and child abuse: is there a relationship?
Many of the family psychosocial variables significantly related to child abuse are also significantly related to insulin-dependent diabetes mellitus (IDDM) control. These variables are reviewed, and an increased child abuse risk factor for children with IDDM is discussed. Behavioral indicators of families experiencing difficulty in coping with IDDM are provided. These indicators are associated with both diabetes control and child abuse and should be recognized by diabetes health-care professionals.
|
A healthy baby has been born at a Dallas hospital to a mother who received a uterus transplant. It’s a medical first for the United States, and an important milestone in the battle against infertility.
|
Heat generating electronic components are often required to be mounted in association with a heat dissipating structure in order to maintain the component temperature within a desired operating temperature range. The heat dissipating structure may be a separate heat sink provided for the purpose of drawing heat from the component, or an existing structure such as a housing containing and/or supporting the component may also form a heat sink for the component.
A particular example of a heat generating electronic component comprises a solid state electronic relay module that may be located within a motor housing. The motor housing may operate as a heat sink, providing a thermal path for heat to travel away from the electronic relay module to an external surface of the housing. The manner in which the electronic relay module is secured to the housing affects various factors including the character of the thermal connection between the module and the housing, the structural stresses exerted on the module due to differences in thermal expansion at the junction between the different parts, as well as affecting the ease of assembly of the module to the housing. Hence, a retention configuration for mounting the module to the housing has typically required a balance between these often conflicting factors.
|
“I was looking forward to a lot more immigration reform from our current president. I supported him.” On what advice he’d give President Obama, Morales said, “Remember what you promised us. I would just say, be true to yourself because every time you don’t, you give the opposition a lot of ammunition to say, you know, where’s that change that was promised?”
Morales appears to still be on board the Hope and Change express, but his candor regarding Obama’s lack of achievement on a key promise is refreshing.
|
Another unhappy ending for a flash-sale shopping site.
Three months after Gilt Groupe sold for a fraction of its valuation, Amazon has decided to shut down its fashion discount competitor MyHabit, according to a person familiar with the move. Amazon launched the website five years ago near the height of the flash-sale craze, but MyHabit has struggled in recent years as the one-time popular fashion niche has become less popular and Amazon has prioritized other fashion initiatives.
Women’s Wear Daily reported employees have been told that the site will shutter at the end of May (subscription). In January, the CEO of MyHabit took on a new role at Amazon as general manager of its new private-label fashion business, according to his LinkedIn profile.
An Amazon spokeswoman did not immediately respond to a request for comment.
Amazon has quietly launched several of its own fashion brands under names Lark & Ro and Franklin & Freeman. Sources say this division will be a huge focus of Amazon’s fashion business going forward. CEO Jeff Bezos confirmed as much when he recently told Fortune magazine that it was one of the areas inside Amazon where he was spending time. “I think there’s so much opportunity for invention there,” he said.
Flash sales, on the other hand, has become an increasingly difficult business in recent years. The model exploded in popularity following the last recession, as designer brands were desperate to sell excess inventory in any way they could. But as the economy rebounded, there was less excess inventory to go around and some brands got smarter about how much inventory they produced.
There have also been segments of the fashion industry that have refused to do business with MyHabit, because of the association with Amazon, which some still view as a brand that represents commodity goods.
|
Uniform Concave Polystyrene-Carbon Core-Shell Nanospheres by a Swelling Induced Buckling Process.
We have developed a facile procedure that can create asymmetrical building blocks by uniformly deforming nanospheres into C(∞v) symmetry at low cost and high quality. Concave polystyrene@carbon (PS@C) core-shell nanospheres were produced by a very simple microwave-assisted alcohol thermal treatment of spherical PS@C nanoparticles. The dimensions and ratio of the concave part can be precisely controlled by temperature and solvents. The concavity is created by varying the alcohol-thermal treatment to tune the swelling properties that lead to the mechanical deformation of the PS@C core-shell structure. The driving force is attributed to the significant volume increase that occurs upon polystyrene core swelling with the incorporation of solvent. We propose a mechanism adapted from published models for the depression of soft capsules. An extrapolation from this model predicts that the rigid shell is used to generate a cavity in the unbuckled shell, which is experimentally confirmed. This swelling and deformation route is flexible and should be applicable to other polymeric nanoparticles to produce asymmetrical nanoparticles.
|
Q:
jquery UI Modal Dialog in asp.net usercontrol: Modal Overlay only on Div in UserControl
I have an asp.net usercontrol that contains a jQuery UI Dialog Control.
All works as expected execpt the grey tranparent overlay (to make the form modal) only appears on the hidden div below the form where the dialog is triggered from.
Is it possible to target this overlay to the parent div? or is this not the right solution.
I have tried the blockUI plugin (and removing the Dialog style to prevent its overlay showing), but although it "looks" right on screen it disables all the controls including the ones in the dialog popup.
Any ideas?
Added: Screenshot
alt text http://www.freeimagehosting.net/uploads/e0555a0ec5.jpg
A:
It might be a z-order issue. Can you post a screenshot to make it easier to understand. Also please post the high level HTML you are using on the aspx page.
|
whisher
We Make Money Not Art recently visited the LABoral Art and Industrial Creation Centre in Gijón, Spain. The installation that left the strongest impression on [Regine] was the WiFi sightseeing telescope built by Clara Boj and Diego Diaz. Spain is in a situation similar to the USA: A few years ago many municipal WiFi projects launched only to be squashed because of theoretical unfair competition with local utilities. Now commercial projects like WeFi, Whisher, and FON encourage people to “share” their WiFi. Observatorio (Observatory) is designed to provide insight into the current state of local WiFi. It uses a highly directional Yagi antenna to collect wireless access data from the local area. The antenna has a 30deg aperture which is matched to a camera with an identical field of view. The observer sees the camera’s viewpoint with the WiFi data overlaid showing where accesspoints are and whether the AP is open. WMMNA also recommends you check out the WiFi Camera which photographs electromagnetic space.
|
[Essential procedure and key methods for survey of traditional knowledge related to Chinese materia medica resources].
The survey of traditional knowledge related to Chinese materia medica resources is the important component and one of the innovative aspects of the fourth national survey of the Chinese materia medica resources. China has rich traditional knowledge of traditional Chinese medicine (TCM) and the comprehensive investigation of TCM traditional knowledge aims to promote conservation and sustainable use of Chinese materia medica resources. Building upon the field work of pilot investigations, this paper introduces the essential procedures and key methods for conducting the survey of traditional knowledge related to Chinese materia medica resources. The essential procedures are as follows. First is the preparation phrase. It is important to review all relevant literature and provide training to the survey teams so that they have clear understanding of the concept of traditional knowledge and master key survey methods. Second is the field investigation phrase. When conducting field investigations, survey teams should identify the traditional knowledge holders by using the 'snowball method', record the traditional knowledge after obtaining prior informed concerned from the traditional knowledge holders. Researchers should fill out the survey forms provided by the Technical Specification of the Fourth National Survey of Chinese Materia Medica Resources. Researchers should pay particular attention to the scope of traditional knowledge and the method of inheriting the knowledge, which are the key information for traditional knowledge holders and potential users to reach mutual agreed terms to achieve benefit sharing. Third is the data compilation and analysis phrase. Researchers should try to compile and edit the TCM traditional knowledge in accordance with intellectual property rights requirements so that the information collected through the national survey can serve as the basic data for the TCM traditional knowledge database. The key methods of the survey include regional division of Chinese materia medica resources, interview of key information holders and standardization of information.' In particular, using "snowball method" can effectively identify traditional knowledge holder in the targeted regions and ensuring traditional knowledge holders receiving prior informed concerned before sharing the information with researcher to make sure the rights of traditional knowledge holders are protected. Employing right survey methods is not only the key to obtain traditional knowledge related to Chinese materia medica resources, but also the pathway to fulfill the objectives of access and benefit sharing stipulated in Convention on Biological Resources. It will promote the legal protection of TCM traditional knowledge and conservation of TCM intangible, cultural heritage.
|
Delivery :
Orange peels contain a wide variety of nutrients and phytonutrients that are very potent in healing many skin conditions.
a. Acne be Gone - Orange peels help to clean out your skin by extracting dirt from deep inside the pores.
b. Orange Peels for Skin whitening - Orange peels are a natural bleacher and can help lighten dark blotches on the skin and effectively remove them with time. Orange peels help reduce suntans besides deflecting harmful UV rays from attacking skin cells.
c. Off with the blackheads - a natural and non-painful way of getting rid of black heads, also unclogs excess oils and dirt clogged within skin pores.
d. Say no to wrinkles - The powerful anti-oxidants in oranges fight off oxygen free radicals that deprive healthy skin cells of oxygen by stealing oxygen molecules from them. These free radicals play a significant role in creating wrinkles in skin and also lead to sagging of cheeks. The significant amount of calcium in orange peels is also very effective for protecting against premature aging of the skin.
e. Tone your Skin - The abundant vitamin c and anti-oxidants in orange peels maintain the oils of the skin-preventing both very oily and dry skin. Applying orange peels on skin helps remove dead cells, dirt and keeps the skin well moisturized and toned. Additionally, calcium contributes to anti-oxidant production that reverses dry skin into looking healthy and glowing
|
Drosophila reproductive behavior will be studied using genetic tools. Questions on the control, by the various parts of the nervous system, of different features of courtship will be asked with genetic mosaics (following up our earlier studies). What parts of the dorsal brain must be male to allow the early steps of courtship to be performed? Are intermediate steps of courtship controlled by the brain, and if so, by the same parts? The later steps of courtship are controlled by male thoracic tissues: is the thoracic ganglion critically involved in such control? For female behaviors, which tissues must have a female genotype in order that a mosaic be receptive to courtship and copulation, or be able to carry out the post-copulation rejection behaviors? -- Several behavioral mutants affecting courtship have been characterized by behavioral observation and manipulation. Different mutants influence the early, middle, or late stages of courtship sequence. The causes of these reproductive defects will be analyzed, beginning with studies of mosaics: For instance, where in the fly must a small genetic duplication--carrying the normal allele of a gene involved in aberrant male-female and male-male interactions--be present in order that normal behavior occur? Some of the experiments here, on mutants and mosaics, will concern the possible genetic control of particular neural oscillators--those that drive motor output in the courtship lovesong. Also, we are dissecting the control of copulation--its basic duration, the relationship of that duration to sperm transfer, and the details of actions involved in its termination. -- The various mutants may affect the development or the functioning of the nervous system. In this light, we will analyze conditional alleles of certain of the mutants, to ask which stage of the life cycle is influenced by the genetic variants. -- We are asking several questions on triggers and inhibitions of courtship behaviors, influenced by putative pheromones. These experiments are related, not only to studies of normal males and females, but also very strongly to the investigations of behavioral mutants, and to the behavioral dissection of the brain in genetic mosaics.
|
Wouldn’t it be funny if A-Rod was juicing again? I mean, it wouldn’t really be funny, but, it sort of would be…right? Sure, for the integrity of the game of baseball, it wouldn’t be funny it would be a disgrace – but there is a small part that would be funny.
I’ll be honest, every time I see him round the bases after hitting a ball outside the park I think to myself “what if he is juicing again?”
Sometime I will say that same statement to a few friends who might be around when I see him hit a home run, and we always get into a nice conversation about it.
I saw A-Rod hit a homerun the other night against the Texas Rangers on his 40th birthday. During the broadcast they showed his career stats in homeruns, RBIs and runs — all of which made me think, what if this guy would have been clean his whole career? And on top of that, what if he would have been healthier throughout his career?
There will always be people who will claim that A-Rod’s numbers come with a huge discrepancy. I am not saying that they don’t, some of them certainly do. But let’s remember that this guy was always a world-class player, even when he was younger in the days before he “beefed up.” The A-Rod in Seattle and Texas was an incredible player and certainly deserved a lot of the accolades he got.
The most amazing thing might be the way the Yankees fans have overwhelmingly forgiven him of all the wrong he has done. Now that might be because of the amazing season he has had so far, but still, to see the city rally around this guy has been shocking.
It almost seems like as long as he is hitting bombs over the fence and driving runs across the plate that the fans don’t even consider this guy has ever done wrong. Now it doesn’t take long to remember that he certainly has done wrong, but for a short time (mainly, while he is on the field) all of that seems to disappear.
I have always had mixed feelings about A-Rod, I used to be a big fan but was so disappointed when he joined the Yankees. I used to really enjoy his play on the field but was disappointed with some of his incidents on the field throughout the years. Oh and then there is the whole taking performance enhancers thing, that too.
But I will say that I have mad respect for the old man getting back out there after a big injury and a huge suspension. It could have been easy for the guy to just take the easy way out and stroll into retirement with a ton of money, but he worked his tail off and has had a great comeback season.
Let’s see how he finishes it as he tries to help the Yankees make the playoffs (which they are currently in line for). But still, it would be pretty funny to find out if he was juicing again for this season — he probably isn’t, I have no idea — but wow, now that would be a story.
Tyler Rollason is a Winder-Barrow High School and University of West Georgia graduate. You can e-mail comments about this column to tyrollason@yahoo.com.
E-Mail addresses will not be displayed and will only be used for E-Mail notifications.
To prevent automated Bots from commentspamming, please enter the string you see in the image below in the appropriate input box. Your comment will only be submitted if the strings match. Please ensure that your browser supports and accepts cookies, or your comment cannot be verified correctly.Enter the string from the spam-prevention image above:
Phone*
What is four plus two?
Remember Information? Subscribe to this entry
Submitted comments will be subject to moderation before being displayed.
|
using System;
using System.Collections.Generic;
using System.ComponentModel;
using System.Linq;
using System.Text;
using System.Threading.Tasks;
using Uno.UI.Xaml;
using Windows.UI.Xaml;
namespace Uno.UI.Helpers.Xaml
{
public static class SetterExtensions
{
[EditorBrowsable(EditorBrowsableState.Never)]
[System.Runtime.CompilerServices.MethodImpl(System.Runtime.CompilerServices.MethodImplOptions.AggressiveInlining)]
// This is normally called from code generated by the Xaml parser
public static Setter ApplyThemeResourceUpdateValues(this Setter setter, string themeResourceName, object parseContext)
{
setter.ThemeResourceName = themeResourceName;
setter.ThemeResourceContext = parseContext as XamlParseContext;
return setter;
}
}
}
|
SEARCH
Sexuality After Prostate Cancer
Impotence, or not being able to maintain an erection to have sex, may be a problem after prostate cancer treatment. This may be temporary or permanent. If you are able to get an erection, you may be able to achieve orgasm. However, no semen will be ejaculated during orgasm. Some people call this dry orgasm.
|
Description
“Prague is beautiful (…) the city is large, cosmopolitan, and distinctly European. I thought (…) that it would be small and manageable, but everywhere I turn there’s a restaurant I want to try or a festival happening or another museum, beergarden, park, or church to explore. I also thought the food would be heavy and fried, so I’ve been surprised at the number of brooklyn style coffee shops, vegan restaurants, and Indian, and Vietnamese food places. The restaurant downstairs serves juices, acai bowl, and aloo gobi sandwiches, and the brewery down the street serves zucchini noodles and carrot chowder. Our workspace is a former embassy and feels regal. We have a library, a sprawling garden in the back, a yoga room, and a neighboring park. (…) Everywhere you turn – local area, tourist area, historical area, run down area – is beautiful and has a past.”
|
But might have different characters to those that appear in the scene, or based of a preliminary story/image which can change.
However, Legolas and Tauriel have have character discriptions saying they follow their hearts and have to chose between what they think is right and Thranduil's wishes. Perhaps it could be in relation to rescuing the dwarves.
|
Q:
After a form is filled once, I blank out the form before filling it the next time (new conversation), but the borders remain red
I have used webshims for html5 form validation in a single page app with multiple pagelets(divs). The forms are not submitted but local javascript is invoked after each conversation and collected data is posted .
Next I iterate over all the fields and reset the values.
Then I take the new user back to the first pagelet having first form for the new conversation. This time even after filling the correct values the border does not turn green.
Note:
However when we select the field and click outside the field without filling it. and then after filling the correct data border turns green.
However when we tried to achieve it programmatically iterating over each field resetting it and using javascript focus method, that did not do the trick.
I am sure I must be missing some thing. would be able to point out what.
Regards
Barman
A:
I'm not sure, what you want to achieve. I would need to see some code. If you change the value programmatically you can update the validation ui with the event refreshvalidityui on the form field. If you want to reset the ui, you can either trigger a reset event on the form or resetvalidityui on the form field
$('input').val('foo').trigger('refreshvalidityui');
or
$('input').val('foo').trigger('resetvalidityui');
or
$('form').trigger('reset');
Please let me know, if this helps.
|
[Atomizers for disinfection].
The disinfection services experience acute demand for atomizers. In view of the fact that operation of all atomizing units is based on the same physical principles and that their use is associated with the solution of the same physical problems, for disinfection needs, use can be made of the equipment manufactured by medical industry as well as of the analogous units applied in related spheres: in veterinary, field-crop cultivation, forestry, horticulture, in carrying out finishing works during construction, and in homes. Atomizers manufactured by different bodies are reviewed. The main characteristics of the units are provided.
|
Q:
Multi Boot USB Stick
I have several Boot CD's/DVD's where I'm able to make a bootable USB-stick and put into it. But I can do this separately only. Is it possible to merge several bootable CD's/DVD's into a single bootable USB-stick where I can choose which system to boot from? I'll be happy for a good link, or if you just tell me the steps with the right expressions that i can google.
A:
Yes this is possible, try out a great application called Yumi it allows you to make a long boot list with an iso if you have it, you can even use unsupported bootable iso's to be included.
A:
This possible using a bootloader like grub - or if you are working with Windows grub4dos
In the config file you can add multiple ISO images you can select from in the boot menu.
Another nice tool for Windows is RMPrepUSB for which you can find a video tutorial on YouTube that shows how to create a bootable USB-Stick. By editing the menu.lst you can add multiple ISO images.
Alternatively if you prefer a clean hardware sulution take a look onto the ISOStick - an USB stick that includes an hardware emulated usb cd/dvd-drive booting from an ISO contained on the stick.
|
module Quickbooks
module Model
class PhysicalAddress < BaseModel
xml_accessor :id, :from => 'Id'
xml_accessor :line1, :from => 'Line1'
xml_accessor :line2, :from => 'Line2'
xml_accessor :line3, :from => 'Line3'
xml_accessor :line4, :from => 'Line4'
xml_accessor :line5, :from => 'Line5'
xml_accessor :city, :from => 'City'
xml_accessor :country, :from => 'Country'
xml_accessor :country_sub_division_code, :from => 'CountrySubDivisionCode'
xml_accessor :postal_code, :from => 'PostalCode'
xml_accessor :note, :from => 'Note'
xml_accessor :lat, :from => 'Lat'
xml_accessor :lon, :from => 'Long'
def zip
postal_code
end
def lat_to_f
BigDecimal(lat)
end
def lon_to_f
BigDecimal(lon)
end
def have_lat?
lat.to_s != "INVALID"
end
def have_lon?
lon.to_s != "INVALID"
end
end
end
end
|
Q:
finding last row in excel and using excel.range
I am attempting to use a reference to interop.excel instead of vba to do some worksheet formatting. My code looks like:
Dim lastrow As Range = excel.Rows.End(XlDirection.xlDown)
Dim findme As Range = excel.Range("A1:A" & lastrow)
the excel.range does not allow me to use the "&" symbol here. How should I identify my last row of data?
A:
Looking at the Range Class Reference, it seems you just missed to put the Row property of the lastrow Range:
Dim findme As Range = excel.Range("A1:A" & lastrow.row)
|
/*
Language: Clojure REPL
Description: Clojure REPL sessions
Author: Ivan Sagalaev <maniac@softwaremaniacs.org>
Requires: clojure.js
Website: https://clojure.org
Category: lisp
*/
export default function(hljs) {
return {
name: 'Clojure REPL',
contains: [
{
className: 'meta',
begin: /^([\w.-]+|\s*#_)?=>/,
starts: {
end: /$/,
subLanguage: 'clojure'
}
}
]
}
}
|
The cell wall of Chlamydomonas eugametos. Immunological aspects.
An antiserum was raised against the major cell wall glycoprotein of Chlamydomonas eugametos which after purification reacted specifically with all individual wall components but not with intact cell walls. The antigenic sites in intact walls appear to be cryptic but become exposed on partial enzymatic degradation or in situ during daughter-cell release when the insoluble component is digested. Using the antiserum as a specific label for cell walls in various stages of disintegration, cell wall digestion during asexual and sexual reproduction was studied. It is also shown that while cell wall material is associated with isolated flagella, it is not normally associated with the flagella of intact cells.
|
North America is home to a plethora of native bees. Sadly, they are a bit of a mystery. Overshadowed by non-native honey bees, many of our native species are in serious trouble. That is where scientists like Dr. Alexandra Harmon-Threatt come in. An assistant professor of entomology at the University of Illinois, her lab is focused on the interactions between native bees and the surrounding plant communities. This is a fascinating discussion that will hopefully inspire more people to dive into the shadows surrounding these important players in our local ecology. This episode was produced in part by Gregory, Mark, Bryan, Laura, Margie, and Allan.
Click here to learn more about Dr. Harmon-Threatt's work
Click here to support this podcast
Music by Moneycat
|
Q:
When using ka, is it acceptable to eliminate the question mark when ending a sentence?
I am unable to find content addressing this question.
A:
For writing in Japanese, question marks after か appear to be less common than simple periods in plain-text formats like novels. For manga, question marks seem to be more common. For writing in romaji, question marks appear to be standard.
Note that this is all from my own subjective perspective.
|
The state legalized medical marijuana more than four years ago, but the Frederick firm is the first that has been authorized to actually grow cannabis. The first crop is not expected to be ready for about two more months.
|
---
apiVersion: rbac.authorization.k8s.io/v1
kind: ClusterRole
metadata:
name: prometheus
rules:
- apiGroups: [""]
resources:
- nodes
- pods
- endpoints
- services
verbs: ["get", "list", "watch"]
- nonResourceURLs: ["/metrics"]
verbs: ["get"]
---
apiVersion: rbac.authorization.k8s.io/v1
kind: ClusterRoleBinding
metadata:
name: prometheus
roleRef:
apiGroup: rbac.authorization.k8s.io
kind: ClusterRole
name: prometheus
subjects:
- kind: ServiceAccount
name: default
namespace: default
|
Inspired by haute couture, our luxury Alaia bedding
features exquisite details including intricate pleating, delicate basket weaves and a muted, metallic color palette. The woven-pattern fabrics and hand-tacked stitching help make this a voguish collection that melds beautiful form with ...
|
[Anti-virus research of triterpenoids in licorice].
Licorice is a leguminous plant of glycyrrhiza. It is a traditional Chinese herbal medicine. Triterpenoid is one of the mainly active components of licorice. In recent years, the broad-spectrum antiviral activity of many triterpenoids in licorice was confirmed, and these findings have become a hot spot of antiviral immunity. The triterpenoids of licorice has the potential to become a novel broad-spectrum antiviral medicine and will be widely used in the clinical treatment. This review provided a summary of the recent anti-virus research progress on several triterpenoids in licorice, such as glycyrrhizic acid, glycyrrhizin, glycyrrhetinic acid and its derivatives. The antiviral roles of triterpenoids in licorice against herpes virus, HIV, hepatitis virus, SARS coronavirus and influenza virus were briefly summarized.
|
Sellers
A few small things can make a big difference when selling your home.
Make first impressions count. Without a doubt, a visually appealing house will attract buyers, who can't help but respond to the look and "feel" of a home. Take time to carefully prepare for showings.
Don't forget the following:
Cut the grass
Remove any clutter from the yard
Trim hedges
Weed gardens
Wash steps, windows, railings, doors, etc
Paint if needed
Remove unnecessary clutter from garages
Scrub, dust and fix up the works. Buyers will notice details. Get rid of the clutter, repair leaky faucets, wage war on dust and clean until your home shines. Small things can make a potential buyer walk away. When you prepare your house for showing, remember to:
Shampoo carpets
Clean tubs, toilets and showers and hang fresh towels
Oil squeaky doors
Fix things like broken hinges and light switches
Listen to suggestions. As you prepare your home, don't rely solely on your own judgement. It's hard to be objective when you're the owner. Your realtor will have helpful, professional tips on how to make your home more marketable.
Take a whiff. Nothing will turn a buyer away faster than an odd smell. Try to eliminate smoking, food and pet odors. And don't leave any clues. If potential buyers see a dog or an ashtray, they'll be on the lookout for smells and stains.
Turn on the lights. Open shades and draperies before a viewing. Open all doors inside home. Turn on inside and outside lights.
Get out of the house. When buyers view your home, they'll be more comfortable and spend more time if you're not there. If you must be present, be as unobtrusive as possible. Let your agent do the work.
Stay unemotional during negotiations. Selling your home can be emotionally charged, but don't let that stand in the way of making a deal. Have a business-like attitude during the process.
Choose a Real Estate Professional you like and trust.
HAVE A QUESTION?
Whether you choose to do business with us or not, we are here to answer any questions you have.
|
Lane Township
Lane Township may refer to the following townships in the United States:
Lane Township, Warrick County, Indiana
Lane Township, Greenwood County, Kansas
See also
Cherry Lane Township, Alleghany County, North Carolina
|
Q:
cloudmade - using the sample code, Marker jumps
I've setup a project with cloudmade.
If if tap on a marker and want to drag it, the marker jumps some pixel.
Any suggestions?
Would be great to get some help :)
Thanks!
A:
I think this problem doesn't occur now..
|
How To Have The Perfect Wedding Day
TIP! Finding your perfect wedding dress might be an expensive activity. When shopping for your dress, consider dresses that may not be categorized as a wedding dress.
It is a great thing when people get married. Weddings are naturally romantic events, but they should also be artistic, aesthetic, and uplifting. A perfectly planned and executed wedding with no unwelcome surprises takes a lot of thought and care to plan. The tips contained within this article will be able to assist you.
TIP! Purchasing a wedding gown online can save a lot of money. If you decide to go this route, purchase the dress early so you will have time to get it altered.
The pictures you will have taken on your wedding day are meant to be a memento of your happy day for a lifetime. Even though it can me costly, your best bet is to have a professional photographer take your pictures so you get the best quality possible.
TIP! The pictures you will have taken on your wedding day are meant to be a memento of your happy day for a lifetime. It pays to spend the extra cash to hire a wedding photographer in order to reduce the chance of some amateur screwing up your wedding photos.
Try using the property of a loved one for the wedding venue. This will help you to significantly reduce the costs. Make sure you offer to hire help to prepare and to clean, though. Do not leave this up to the homeowner.
TIP! Try using the property of a loved one for the wedding venue. If you know anyone with a large enough backyard, you can save a lot of money on your wedding.
Getting married soon? Don’t even think about crash dieting to fit into your dress. Like any athlete will tell you, too much weight loss too quickly can result in being light-headed and dehydrated. You want to stay on your feet during the ceremony and reception. You would do better to choose a dress that has a corset back, as this allows you to adjust the fit with out the need for tailoring.
TIP! Don’t starve yourself silly just to fit in a wedding dress. You may not feel good on the big day if you haven’t eaten enough.
It is obvious that that most important aspect to think about in a marriage is the one whom you will marry. Don’t rush into this decision. Be sure you carefully take into account the traits that you require in a mate, and which ones will drive you insane.
TIP! The single most important factor when you are getting married is also the most obvious, your choice in bride or groom. This is a huge commitment, and rushing into things for the sake of being married may be catastrophic.
Do your research when it comes to your photographer. You do not want to have someone taking wedding pictures that you are not pleased with. There are online reviews readily available to you, and you can also ask people you know that might have planned a wedding recently.
TIP! If you want to maximize your look on the day of the wedding but are on a budget, one of the things that you can do is to rent diamonds. This gives you that dazzling look you are seeking for a fraction of the cost, which allows you to stay well within your budget.
You can embellish your bouquet with tiny crystals, rhinestones or perhaps diamonds if you can afford to. This can be done with the addition of adhesive or thermally attached crystals, smaller pieces of costume jewelry and maybe even a cherished heirloom. For a consistent look, all of the stones should coordinate in terms of cut, color, and size.
TIP! Take your time in writing your vows, they’re personal and meaningful and must have effort put into them. Keep in mind that the union of marriage is a long term commitment and will require both parties to make some sacrifices.
Make sure your wedding reception lighting can be dimmed at the venue. Certain occasions throughout the evening will call for their own separate mood and lighting, such as a first dance or cutting of the cake. Check with the venue about these specific options before booking anything for certain.
TIP! Of course you probably know to tell your DJ or band what songs you expect, but also consider telling them songs you absolutely do not want at your wedding. Perhaps it’s heavy metal, or country music, or even a previous lover’s “special song”.
When you are planning table seating, try to set guests in pairs, so you can ensure every table has an even number of those sitting at it. Facilitate conversation by making table arrangements according to age groups.
TIP! Be sure to browse around for experienced and skilled photographers, before you commit to one for your wedding. You don’t want a photographer who disappoints.
Place your colorful wedding cake on a swatch of fabric that coordinates with the cake. You can use solids, patters, silk, velvet or satin to tie the elements all together.
TIP! Post a schedule of events on your wedding website or send an itinerary with your wedding invitations. This helps out-of-town guests make appropriate travel plans, especially guests who are going to participate in your wedding rehearsal or other events.
Weddings are joyous occasions but they also bring a lot of stress and drama into play. Avoid wedding collapses, by using the advice you learned from this guide, to your advantage.
|
President Trump is inciting a trade war, undermining NATO and painting Europe as a foe. It’s no wonder, then, that the European Union is looking elsewhere for friends.
On Tuesday in Tokyo, it signed its largest trade deal ever, a pact with Japan that will slash customs duties on products like European wine and cheese, while gradually reducing tariffs on cars. The agreement will cover a quarter of the global economy — by some measures the largest free-trade area in the world — and is the latest in a string of efforts either concluded or in the works with countries like Australia, Vietnam and even China.
The deal with Japan, and the others being negotiated, point to a more assertive Europe, one that is looking past the frosty ties with the United States, and even the coming withdrawal of Britain from the bloc. In recent months, European Union leaders have voiced ever more confident support for free trade, refusing to back down in the face of the threat of tariffs from Washington and instead aggressively courting new relationships.
But no matter how many barriers to international commerce the European Union manages to tear down, its leaders will not change one economic fact of life: The United States remains the Continent’s largest trading partner. There is no escaping the damage from Mr. Trump’s campaign against imports like cars and steel.
|
Though the comic series may have been canceled, motion comics are still trickling out to expand Overwatch's lore. The latest issue looks at Doomfist, his escape, his plans, and his fashion sense.
Overwatch rarely gives its lore in-game. Rather, it uses third parties like cinematics and comics to expand the universe's story. The latest entry into the Big Book of Overwatch Lore focuses not only on the newest hero, Doomfist, but the other (known) members of Talon as well. The comic not only shows off Doomfist's first stop after his prison break (literally), but also some of the clothes the organization likes to wear when the mood strikes them.
While it's not a guarantee these festive threads will make their way in game, a betting man wouldn't balk at the chance to put money on their inclusion. Elements from the comics have made their way into the game before, like Reaper's shrug emote. Who wouldn't want a Reaper costume with a big floppy hat and big puffy pants? That's right, no one.
New faces show up in the motion comic as well. Though betting on any of them showing up in game is a far riskier bet than the costumes, any new character introduced to the lore immediately as their look analyzed and their movesets theorized. Hell, before we saw the Doomfist we have now, people speculated that the little kid in the first Overwatch cinematic was going to be wielding the gauntlet of destruction.
So what do you think? Do the costumes look good, and do you want them in game? How about those new faces that show up prominently, and in the shadows – do you think they'll make their way onto the video game battlefield? Let us know in the comments!
|
using System;
using System.Collections.Generic;
using System.Linq;
namespace NAPS2.Platform
{
public interface ISystemCompat
{
bool IsWiaDriverSupported { get; }
bool IsTwainDriverSupported { get; }
bool IsSaneDriverSupported { get; }
bool CanUseWin32 { get; }
bool UseUnixFontResolver { get; }
bool IsWia20Supported { get; }
}
}
|
Combining tactics to exploit Allee effects for eradication of alien insect populations.
Invasive species increasingly threaten ecosystems, food production, and human welfare worldwide. Hundreds of eradication programs have targeted a wide range of nonnative insect species to mitigate the economic and ecological impacts of biological invasions. Many such programs used multiple tactics to achieve this goal, but interactions between tactics have received little formal consideration, specifically as they interact with Allee dynamics. If a population can be driven below an Allee threshold, extinction becomes more probable because of factors such as the failure to find mates, satiate natural enemies, or successfully exploit food resources, as well as demographic and environmental stochasticity. A key implication of an Allee threshold is that the population can be eradicated without the need and expense of killing the last individuals. Some combinations of control tactics could interact with Allee dynamics to increase the probability of successful eradication. Combinations of tactics can be considered to have synergistic (greater efficiency in achieving extinction from the combination), additive (no improvement over single tactics alone), or antagonistic (reduced efficiency from the combination) effects on Allee dynamics. We highlight examples of combinations of tactics likely to act synergistically, additively, or antagonistically on pest populations. By exploiting the interacting effects of multiple tactics on Allee dynamics, the success and cost-effectiveness of eradication programs can be enhanced.
|
Q:
How to send data from an Android application to a server?
I'm developping an online Chess game in Android. The first player uses the app and the second a webpage in html.
What i want to do is to send the text with the information of every move each player makes in his turns. All the processing and validation parts of the game will be done in the Android application. The second player just receives the text, parses it into html code and then send a very similar text to the application in order to receive the authorisation of the move.
I'm really trying to spend the least possible of internet resources.
I've been searching what's my best option in order to send the messages with Android, but since I'm not very experienced with it, I don't know what to do.
I found these possibilities for sending the messages:
GCM
Android ServerSockets and Sockets
Making Push technology, like long-polling
I have never used any of those technologies, but I would like to know which one could be the best for starting to make a deeper research of.
As you can see a chess game doesn't need a great amount of messaging since I have to send and receive a single message per move and per the authorisation of it by the chess engine in the Android application.
If you know a better solution or links with an example of the technology I should use, I would be very grateful.
A:
On your case it's just matter if the the Android player will need to be with the app running (real time play) or there will be the option to send the play, play turn off the app, and see the next move in a few hours?
If it's a real time just open the connection and use polling or sockets to keep the game running.
If it won't be a real time game, GCM is probably your best approach.
But remind that both options will mean you'll need your own web-server running stuff.
|
Q:
What is the scope of Self?
I am asking to advance my understanding of Self.
Please consider the following:
type
PTestObject = ^TTestObject;
TTestObject = class(TObject)
private
FCaption : String;
public
procedure MakeThePointer;
property Caption : String read FCaption write FCaption;
end;
TForm4 = class(TForm)
ButtonFirst: TButton;
ButtonSecond: TButton;
ButtonThird: TButton;
procedure ButtonFirstClick(Sender: TObject);
procedure ButtonSecondClick(Sender: TObject);
procedure ButtonThirdClick(Sender: TObject);
private
public
end;
var
Form4: TForm4;
PointerOfTest : PTestObject;
TestObj : TTestObject;
implementation
{$R *.dfm}
procedure TTestObject.MakeThePointer;
begin
PointerOfTest := @Self;
end;
procedure TForm4.ButtonFirstClick(Sender: TObject);
begin
TestObj := TTestObject.Create;
TestObj.Caption := 'Hello';
TestObj.MakeThePointer;
end;
procedure TForm4.ButtonSecondClick(Sender: TObject);
begin
TestObj.MakeThePointer;
ShowMessage(PointerOfTest^.Caption);
end;
procedure TForm4.ButtonThirdClick(Sender: TObject);
begin
// TestObj.MakeThePointer; - Because I do not do this I get Access Violation
ShowMessage(PointerOfTest^.Caption);
end;
The idea is to create a pointer to TestObj's Self and then later access it again. If I call MakeThePointer in the same Click event (ButtonSecondClick) where I access that pointer it works fine. If I do not call MakeThePointer before accessing the pointer (ButtonThirdClick) then it seems that TestObj's Self does not exist in such a way that the previously created pointer is valid and I get an Access Violation.
Please correct me if I am wrong but I assume that Self is a variable local to each of the object's methods. Thus it will have scope only for each of that methods separately?
Now consider this... If that is the case then why does the following work if ButtonFirst is clicked, then ButtonSecond? It seems that the Self variable has landed on the same address thus allowing the following to work. May I assume that the Self variable will always be on the same address or will it change?
type
TFormOther = class(TForm)
ButtonFirst: TButton;
ButtonSecond: TButton;
procedure ButtonFirstClick(Sender: TObject);
procedure ButtonSecondClick(Sender: TObject);
private
public
procedure MakeThePointer;
procedure SetTheCaption;
end;
var
FormOther: TFormOther;
PointerOfForm : ^TForm;
implementation
{$R *.dfm}
procedure TFormOther.MakeThePointer;
begin
PointerOfForm := @Self;
end;
procedure TFormOther.SetTheCaption;
begin
PointerOfForm^.Caption := 'Hello';
end;
procedure TFormOther.ButtonFirstClick(Sender: TObject);
begin
MakeThePointer;
end;
procedure TFormOther.ButtonSecondClick(Sender: TObject);
begin
SetTheCaption;
end;
A:
What is the scope of Self?
In a method Self is best thought of as a local variable. Its address, @Self, is therefore valid until the method returns.
This explains why your code fails. Your code dereferences the pointer after the method has returned, by which point the pointer is not valid.
May I assume that the Self variable will always be on the same address?
No you may not.
I think your problems start here:
type
PTestObject = ^TTestObject;
Because TTestObject is a class, a variable of type TTestObject, such as your Self, is a reference. A reference is a fancy name for a pointer. In this case, your Self, inside methods of TTestObject is a pointer to the instance.
So use TTestObject instead of ^TTestObject and your problems dissolve.
|
Q:
Difference between LINQ Queries & Lambda expression
Why to use lambda expression when we have LINQ queries just to shorten the length of code , increase the speed of development or is there any other reason which can only be achieved by Lambda expression & not by LINQ queries.
A:
Query expressions only cover a small subset of the LINQ operators, and are only applicable when you have the actual expression involved to hand, rather than (say) having a Func<T, bool> to act as the predicate, in which case things become ugly. So instead of writing:
Func<Foo, bool> predicate = ...; // Get predicate from somewhere
var query = from x in collection
where predicate(x)
select x;
I'd much rather write:
Func<Foo, bool> predicate = ...; // Get predicate from somewhere
var query = collection.Where(predicate);
There are various other cases where using non-query expression syntax is simpler, particularly if your query only uses a single operator.
Query expressions are effectively translated into non-query expressions, so anything you can do in query expressions can be expressed in non-query expressions. Use query expressions where they make the code simpler and more readable; don't use them where they don't.
I have more information about how query expressions work in a blog post that you may be interested in.
A:
any other reason which can only be achieved by Lambda expression & not by LINQ queries.
There are some LINQ extension methods which do not have counterparts in LINQ query expressions, and will require the use of Lambda Expressions. A good example is Enumerable.ToLookup - if you want to create an ILookup, you need to use lambdas to generate this.
|
Okay, so, I was trying to figure out when the next new House would show. I ended up finding a summary for it, which made me go OMGWTF.
"While the staff tries to diagnose a woman suffering from uncontrollable muscle flailing and crashes her car, House and Stacy try to resolve their relationship issues once and for all. Cameron refuses to get the results of her HIV test."
So, uh, that's how this happened.
niqaeli: ...zomg. They didn't drop the plotline entirely! TV.com's summary for Need to Know: "While the staff tries to diagnose a woman suffering from uncontrollable muscle flailing and crashes her car, House and Stacy try to resolve their relationship issues once and for all. Cameron refuses to get the results of her HIV test." jmtorres: *eyeroll* niqaeli: Yeah, what did you expect? jmtorres: cameron, you dumbfuck niqaeli: But yu know what would be beautiful? If Cam refused but Chase got his and was positive. jmtorres: HA niqaeli: And he's like, "No, really you need to go get those results RIGHT NOW." niqaeli: House: *blink* Why do you care so much about Cameron being a moron? Unless... niqaeli: Chase: *glare* niqaeli: House: Well, crap. niqaeli: Wilson: What did I miss? jmtorres: House: *starts hitting on Foreman* Foreman: WTF, man? House: You're the only safe one left. Foreman: ... House: Who saw that coming? It's so statistically unlikely! Foreman: Oh, screw *you.* House: My point exactly. niqaeli: Hee! niqaeli: Wilson: ...what, I'm chopped liver? niqaeli: House: Yes. You'd go well with onions.
And a little later:niqaeli: But, seriously. House would be all "Dammit, I'm losing two of my people and screw this Foreman-is-my-boss shit, they're my people. Two! I had them all broken in and comfy." niqaeli: Wilson: Yes, it's so hard breaking the spirit in one's minions. jmtorres: lol niqaeli: House: *sticks his tongue out* Wilson: You know, you are allowed to be upset about this. I won't tell anyone that the big bad House has human emotions. niqaeli: House: Oh, you know how to woo a man. Take me now, Jimmy. niqaeli: Wilson: *sigh* James. And stop deflecting. I know you better. I may be the only person who does. niqaeli: House: This is touching, really. You, reaching out to the bitter asshole. Me, deflecting it and being the bitter asshole. If only my heart would melt already, we could be a Lifetime movie. niqaeli: Wilson: You know, this is not your most attractive side. House: Which does make one wonder why you put up with me. Wilson: Oh, we both know that one. Seriously, though. You enjoy tormenting Cameron and have some small, tiny measure of affection for her due to all the fun you can have with her and you actually, against all reason, like Chase. Despite the crap he pulled on you with Vogler. I think you must be attracted to him, the only other people you let get away with that much are Stacy and me. House: Yeah, okay, I'm upset. You got me. Can we move on? Please? You know what chick flick moments do to my bowels. Wilson: Yeah. Sure. niqaeli: Elsewhere:
Cameron: I can't believe you! Chase: I'm not the one who was being avoidant and stupid. Cameron: You never told me! Chase: What, thanks for the sex that was a really bad idea and by the way I might have been exposed too? Cameron: Yes! Chase: You have martyr complex the size of Mount Rushmore, like you needed that? Besides, it was... I was sober, you weren't. If this is anyone's fault, it's mine.jmtorres: Cameron: Okay, now you're just treating me like a child. Chase: You were on DRUGS.niqaeli: Cameron: Yeah, okay, but really. I made a stupid choice, you made a stupid choice.niqaeli: Chase: *stares at Cam*
|
Alternative splicing: therapeutic target and tool.
Alternative splicing swells the coding capacity of the human genome, expanding the pharmacoproteome, the proteome that provides targets for therapy. Splicing, both constitutive and regulated forms, can itself be targeted by conventional and molecular therapies. This review focuses on splicing as a therapeutic target with a particular emphasis on molecular approaches. The review looks at the use of antisense oligonucleotides, which can be employed to promote skipping of constitutive exons, inhibit inappropriately activated exons, or stimulate exons weakened by mutations. Additionally this manuscript evaluates methods that reprogram RNAs using reactions that recombine RNA molecules in trans. Preliminary, but exciting, results in these areas of investigation suggest that these methods could eventually lead to treatments in heretofore intractable ailments.
|
Bacterial Spores in Food: Survival, Emergence, and Outgrowth.
Spore-forming bacteria are ubiquitous in nature. The resistance properties of bacterial spores lie at the heart of their widespread occurrence in food ingredients and foods. The efficacy of inactivation by food-processing conditions is largely determined by the characteristics of the different types of spores, whereas food composition and storage conditions determine the eventual germination and outgrowth of surviving spores. Here, we review the current knowledge on variation in spore resistance, in germination, and in the outgrowth capacity of spores relevant to foods. This includes novel findings on key parameters in spore survival and outgrowth obtained by gene-trait matching approaches using genome-sequenced Bacillus spp. food isolates, which represent notorious food spoilage and pathogenic species. Additionally, the impact of strain diversity on heat inactivation of spores and the variability therein is discussed. Knowledge and quantification of factors that influence variability can be applied to improve predictive models, ultimately supporting effective control of spore-forming bacteria in foods.
|
IFN-alpha treatment of p190 bcr abl transgenic mice.
Interferon-alfa (IFN-alpha) is one of the most effective drugs in the treatment of chronic myeloid leukemia (CML). Recently, IFN-alpha has also been tried in the treatment of Ph-positive acute lymphoid leukemia (ALL), a disease in part sharing the same molecular genetic lesion as CML, namely a BCR/ABL fusion gene. In the present study we analyzed the effect of IFN-alpha (rHuIFN-alphaA/D) on a mouse model for Ph-positive ALL - mice transgenic for the P190 BCR/ABL fusion gene. IFN-alpha treatment was started in the early leukemic phase and continued throughout the course of the disease in eight transgenic animals. No prolonged survival or altered disease pattern with regard to the development of leukemia and/or lymphoma was observed. We conclude that IFN-alpha, at least in a transgenic setting, does not interfere with the leukemogenic process induced by the P190 BCR/ABL fusion gene.
|
Haha I love this! ALL THE YESToon Link's expression is my absolute favorite, it looks like he doesn't want his picture taken at all XDAnd I thought it was all the Links together until I saw Ben. That scared me XD
Young Link is so damn adorable, he'd be my first choice for a well-deserved squish and hug xDD Nice attention to detail with Skyward's earrings, and BEN's expression is just about the perfect amount of creep xD I always love your hero renditions ^^
|
Q:
How to get unmatched records using SQL query?
Actually if i am doing INNER JOIN of two tables then i will get all matched records from the two tables.
But i want to get all the unmatched rows only.
Is there any way to do that?
Or Any JOIN available for that?
A:
There is join you can use. You need an OUTER JOIN, and only select rows with a NULL on the join condition.
Another option is to use a sub query with a NOT EXISTS or NOT IN as part of your main WHERE clause.
|
Q:
Image over Image CSS
I am creating a webpage and I am trying to put a png (buttons) over gif files.
When the page renders, it makes the png file appear after or under the gif file.
I tried using and tags but neither work. I have also tried using various CSS padding, alignments etc. but it doesn't seem to work.
Is there a way (code) to get images to appear on top of images?
A:
Each element in a page has a particular stacking order. If you do not set them explicitly then it will be stacked in accordance to the order in DOM.
You can control the stacking order by setting the property
z-Index
The higher the z-index value goes the higher will be the stacking order for the element.
If you can set the gif image as the background of a cell then
background-image
property will be the best one. First set the gif image as a background to the cell and place the png button in the cell and position it inside the cell.
A:
Use the "background-image" CSS attribute on a block-level element (<div>, <td> etc.) for the background GIF, then place the PNG buttons inside that block element.
Like this:
<style type="text/css">
div#withBackground {
background-image: url('bitmaps/bg-image.gif');
background-repeat: no-repeat;
}
</style>
<div id="withBackground">
<img src="bitmaps/fg-image.png" />
</div>
|
Field of the Invention
The present invention relates to methods for increasing the generation of positive transformants of a filamentous fungal host cell expressing multiple recombinant polypeptides.
Description of the Related Art
Recombinant production of a polypeptide in a filamentous fungal host cell may provide for a more desirable vehicle for producing the polypeptide in commercially relevant quantities. The recombinant production of a polypeptide is generally accomplished by constructing an expression cassette in which the DNA coding for the polypeptide is placed under the expression control of a promoter from a regulated gene. The expression cassette is introduced into the host cell, usually by plasmid-mediated transformation. Production of the polypeptide is then achieved by culturing the transformed host cell under inducing conditions necessary for the proper functioning of the promoter contained on the expression cassette.
Filamentous fungal cells may be transformed with a vector by a process involving protoplast formation, transformation of the protoplasts, and regeneration of the cell wall in a manner known per se. Co-transformation of two or more vectors expressing multiple recombinant proteins does not efficiently provide positive transformants producing significant amounts of the multiple recombinant polypeptides.
There is a need in the art for methods that improve the efficiency of obtaining positive transformants producing significant amounts of multiple recombinant polypeptides to reduce the number of transformants to be screened compared to positive transformants generated by co-transformation of vectors for each of the multiple recombinant polypeptides.
The present invention provides improved methods for the generation of positive transformants of a filamentous fungal host cell expressing multiple recombinant polypeptides.
|
Posttransurethral prostatic resection hyponatremic syndrome: case report and review of the literature.
Hyponatremia is a potentially life-threatening complication of transurethral prostatic (TURP) resection. The post-TURP syndrome, although well-recognized by urologists, is not discussed in recent clinical reviews on hyponatremia. We present a case report and review of the literature of this striking clinical syndrome.
|
Wwp2 targets SRG3, a scaffold protein of the SWI/SNF-like BAF complex, for ubiquitination and degradation.
SRG3 plays essential roles both in early mouse embryogenesis and in extra-embryonic vascular development. As one of the core components of the SWI/SNF-like BAF complex, SRG3 serves as the scaffold protein and its protein level controls the stability of the BAF complex, which controls diverse physiological processes through transcriptional regulation. However, little is known about how the protein level of SRG3 is regulated in mammalian cells. Previously, we identified a murine ubiquitin ligase (Wwp2) and demonstrated that it interacts with pluripotency-associated key transcription factor Oct4 and RNA polymerase II large subunit Rpb1, promoting their ubiquitination and degradation. Here, we report that Wwp2 acts as a ubiquitin ligase of SRG3. Our results show that Wwp2 and SRG3 form protein complexes and co-localize in the nucleus in mammalian cells. The interaction is mediated through the WW domain of Wwp2 and the PPPY motif of SRG3, respectively. Importantly, Wwp2 promotes ubiquitination and degradation of SRG3 through the ubiquitin-proteasome system. The expression of a catalytically inactive mutant of Wwp2 abolishes SRG3 ubiquitination. Collectively, our study opens up a new avenue to understand how the protein level of SRG3 is regulated in mammalian cells.
|
Fatty acyl CoA esters as regulators of cell metabolism.
Long chain fatty acyl CoA esters have the ability to interact with certain proteins and thereby serve as effectors in cell metabolism. In particular, they can displace nucleotides from specific nucleotide dependent or binding proteins and interfere with their action. The ADP/ATP carrier and uncoupling protein are two examples where the interplay of nucleotide and acyl CoA binding to the proteins regulate their function. Other proteins such as glucokinase can be considered in this group. In certain tissues like liver they are affected during fasting and insulin deficiency, and when serum fatty acids and liver acyl CoA levels are elevated. More recently, an acyl CoA binding protein in E. coli has been found to be a transcription factor for gene regulation of fatty acid metabolism enzymes. There appears to be some consensus in the amino acid sequence for acyl CoA binding sites on these proteins which serve a variety of important roles in cellular metabolism.
|
Development of method of semantic description of works of projects and selection of suitable performers
In article presented the definition of semantic description and management and describes the language of formal problem statements and requirements that are on them. The elements of the semantic description of knowledge on the prepared project. The method of choice with the artists are required to perform design work skills.
Keywords:
qualifications of personnel, elements semantic description of works of project, description is property of objects of concepts, function of choice of precedents, degree of closeness, choice of performers
|
namespace kri.sound
import OpenTK.Audio.OpenAL
public class Source:
public final handle as uint
public node as kri.Node = null
public def constructor():
handle = AL.GenSource()
def destructor():
kri.Help.safeKill({ AL.DeleteSource(handle) })
public Relative as bool:
set: AL.Source( handle, ALSourceb.SourceRelative, value )
public Looping as bool:
set: AL.Source( handle, ALSourceb.Looping, value )
public Streaming as bool:
set:
type = (ALSourceType.Static, ALSourceType.Streaming)[value]
AL.Source( handle, ALSourcei.SourceType, cast(int,type) )
public Position as OpenTK.Vector3:
set: AL.Source( handle, ALSource3f.Position, value )
public Velocity as OpenTK.Vector3:
set: AL.Source( handle, ALSource3f.Velocity, value )
public Direction as OpenTK.Vector3:
set: AL.Source( handle, ALSource3f.Direction, value )
public SecOffset as single:
set: AL.Source( handle, ALSourcef.SecOffset, value )
public def init(buf as Buffer) as void:
AL.Source( handle, ALSourcei.Buffer, buf.handle )
public def play() as void:
AL.SourcePlay(handle)
public def stop() as void:
AL.SourceStop(handle)
|
We believe that Electronic Voice Phenomena (EVP) is so important to the research and understanding of paranormal activity; that it had to be reflected in our name. Also listening for the (spirit voices) as they occur in "real time" through the digital audio recorder allows the investigator to determine quickly how intense the paranormal activity may be.
Brad, Allan and I have never been to a haunted location that did not have EVP present, during the investigation. Spirit orbs are also present in our video recordings and digital photography. Our experience shows us that EVP and spirit orbs can be detected in most hauntings. Everyone is welcome to contact us and share their experience or beliefs.
|
Not my pictures
At a conference in Japan, a Dell laptop suddenly exploded into flames, and lucky for its owner the fiery blast occurred while the PC was sitting on a table and not in his lap. An onlooker reported that the notebook continued to burn, producing several more explosions over the course of about five minutes.
|
Harold Thomas Martin III
#REDIRECT Harold T. Martin III
|
There hasn't been a lack of strange things turning up in the Ashley Madison data leak. One of the latest discoveries comes from Trend Micro, which found bogus Ashley Madison profiles that used email addresses the company created solely for collecting spam samples.
|
Sell my home fast: find a realtor
If you are on a mission to sell my home fast, find a realtor who specializes in marketing quick sales as he or she will have the experience you need.
Selling your home can be a long and drawn out process. Inspections, appraisals and house showings are all components of the process. If you want to sell your home fast and find a realtor, you must research your options carefully. You should also consider the status of the current market in order to find the best realtor who can help you complete the home sale.
Home sales take an average of eight months. If you want to speed up the process search for a realtor who specializes in quick sales and creative marketing. You need a listing agent who knows how to price a house to sell quickly and advertise it as a quick sale.
When you want to sell a home fast, half of the process is choosing a real estate agent who fits your needs and personality. Shop around. Make sure that the person you hire is a member of the National Association of Realtors (NAR). Realtors differ from real estate agents in that they must be official members of the NAR and must follow the organization's strict ethics and codes when working with a client. Set up consultations with a few chosen realtors to determine if your working styles are similar. If you want to sell your home fast, you and your chosen realtor must be able to work together swiftly and efficiently. A realtor who does not mesh well with your standards will slow down your home-selling process.
After hiring a realtor, you must get your home ready for visitors. A large part of selling a home involves the use of visuals. If your home is not particularly eye-catching, you may have trouble selling it. Most home buyers will not submit an offer if your home seems to need a lot of work. Clearing clutter from your home is one of the most important steps. Each room should give off an aura of cleanliness and serenity when a potential buyer walks in. If you need help, hire a professional organizer to help you remove clutter and stage your home. When you want to sell a home fast, find a realtor who is honest about the look and feel of your home. He or she knows what buyers want to see.
To talk with prospective realtors today, go to RealtyNow. A professional will provide home values and tips to get your home ready to sell.
|
/**
* Copyright (c) Microsoft Corporation. All rights reserved.
* Licensed under the MIT License. See License.txt in the project root for
* license information.
*
* Code generated by Microsoft (R) AutoRest Code Generator.
*/
package com.microsoft.azure.management.network.v2019_09_01;
import com.microsoft.azure.arm.collection.SupportsCreating;
import com.microsoft.azure.arm.resources.collection.SupportsDeletingByResourceGroup;
import com.microsoft.azure.arm.resources.collection.SupportsBatchDeletion;
import com.microsoft.azure.arm.resources.collection.SupportsGettingByResourceGroup;
import rx.Observable;
import com.microsoft.azure.management.network.v2019_09_01.implementation.DdosCustomPoliciesInner;
import com.microsoft.azure.arm.model.HasInner;
/**
* Type representing DdosCustomPolicies.
*/
public interface DdosCustomPolicies extends SupportsCreating<DdosCustomPolicy.DefinitionStages.Blank>, SupportsDeletingByResourceGroup, SupportsBatchDeletion, SupportsGettingByResourceGroup<DdosCustomPolicy>, HasInner<DdosCustomPoliciesInner> {
}
|
I feel like it’s not necessary to say much about this jumpsuit. It is clearly gorgeous! As soon as I saw it on Tobi’s website I thought: I need to have it! Haha And I honestly don’t feel like that very often. Even though I’m a personal style blogger and have a lot of clothes, I feel like is becoming harder and harder to fall in love for a garment. It’s like I have worn so many clothes and now need some pieces more different and audacious.But I have always loved jumpsuits and I especially love how they make my legs look longer. I think it’s a great trick for those who are unhappy with their height and want to look a little taller. And the look is easily elevated with the help of the deep cleavage and side cuts in the waist area.
|
Virtual Machine: If you are running DownStream software in a virtual environment, do
NOT install this EXE. Please contact Technical Support
for the correct DownStream License Manager Installation. The software will NOT install properly until you supply us with the Host ID and we supply you with a new license!
(Note: If you are a current user updating your software, select "Install License
File from Installation Media� option. This option will replace your current license file with an updated
license embedded into the software installation.
Thank you for your continued trust and support
DownStream Software Notice: If you are downloading this executable without a license
file, you will only be able to activate CAM350 in a very limited demo
mode. All DownStream software products require a valid license for
successfully activation and use. To implement a full evaluation, please
contact Sales for a temporary license file.
|
Unifying Ambiance Set
Fills the air with a comforting atmosphere.
Bring about a sense of well-being with the comforting combination of lavender, eucalyptus and peppermint oils. Disperse pure essential oil with an elegant aroma diffuser, inspired by the ripening lotus bud of the east.
|
The assault came a day after Bahrain declared a three-month state of emergency and handed wide powers to the armed forces, as it moved to quell weeks of demonstrations by mainly Shiite protesters a day after the arrival...
|
Community Outreach
The Center recognizes that science education occurs in many venues. The Center partners with local community groups to customize learning experiences.
Visits from schools, scout groups and other adult community groups are welcome! The Center has hosted visits from a Cub Scout Pack, who examined their own cheek cells and learned that DNA was in the nucleus of the cell, and a local high school biotechnology class who learned to passage cells in culture and how to stain mitochondria. Another high school group learned about DNA sequencing and its applications. Please contact the director to arrange a visit.
|
Inhibitors of BACE for treating Alzheimer's disease: a fragment-based drug discovery story.
Several fragment-based methods have been applied to the discovery of new lead sources for inhibitors of BACE1, an important therapeutic target for Alzheimer's disease. Among the most common fragment hits were various amidine-containing molecules in which the amidine engaged in discrete H-bond donor-acceptor interaction with the BACE1 catalytic dyad. Structure and medicinal chemistry knowledge-based optimization with emphasis on ligand efficiency resulted in identification of a key pharmacophore comprising a non-planar cyclic amidine scaffold directly attached to a phenyl group projecting into S1. This key pharmacophore is a common feature of known clinical candidates and has dominated the recent patent literature. A structural comparison of the non-planar cyclic amidine motif with other BACE1 pharmacophores highlights its uniqueness and distinct advantages.
|
Validation of large particle flow cytometry for the analysis and sorting of intact pancreatic islets.
Accurate quantification of total islet yield is an essential step prior to transplantation and for research. The standard method of manually determining an islet equivalent (IEQ) count is subjective and prone to error. We evaluated Complex Object Parametric Analyzer and Sorter (COPAS) large particle flow cytometry for the determination of islet equivalent counts and purities of islet preparations. Initial validation of the sensitivity and accuracy of the COPAS flow cytometer was performed by analysis and sorting of uniform polystyrene microspheres with sizes similar to islets. Human and Rhesus monkey islets were stained with the zinc-specific fluorescent dye Newport Green to discriminate islet from nonislet tissue. Islet sizes were extrapolated from standard curves obtained using microspheres from which individual islet volumes were calculated. IEQ counts on six islet preparations were performed by the standard manual method and compared with results obtained by automated COPAS flow cytometry. The COPAS flow cytometer was highly accurate in the detection and measurement of both polystyrene microspheres and islets. IEQ counts determined by COPAS flow cytometry were consistent with manual counts although subject to error when assessing preparations with significant numbers of islets embedded within acinar tissue. Size-specific islet sorting with retention of morphology and dithizone staining was also shown using the COPAS flow cytometer. COPAS large particle flow cytometry provides a novel automated approach for quantification of intact islets and determination of islet equivalent yield. In addition, the ability to analyze and sort islets based upon user defined criterion opens unique avenues for experimentation.
|
Occulocerebrocutaneous syndrome: a case report.
Occulocerebrocutaneous syndrome is a rare condition characterized by orbital cysts and skin tags. The presence of supernumerary teeth has not previously been associated with this syndrome. A primary supernumerary tooth with a permanent supernumerary successor was found in this case. This highlights the importance of very careful examination when assessing children with syndromes.
|
Synopsis
Gone Girl With his wife’s disappearance having become the focus of an intense media circus, a man sees the spotlight turned on him when it’s suspected that he may not be innocent.The day of his fifth wedding anniversary, writing teacher Nick Dunne returns home to find that his wife Amy is missing. Her disappearance receives heavy press coverage, as Amy was the inspiration for her parents’ popular Amazing Amy children’s books. Detective Rhonda Boney does a walkthrough of their house and finds poorly concealed evidence of a struggle. The police conduct a forensic analysis and uncover the remnants of cleaned blood stains, leading to the conclusion that Amy was murdered. Suspicions arise that Nick is responsible, and his apathetic behavior is interpreted by the media as characteristic of a sociopath.Flashbacks reveal that Nick and Amy’s marriage had disintegrated; both lost their jobs in the recession and moved from New York City to Nick’s hometown of North Carthage, Missouri.
Nick became lazy and distant, and began cheating on Amy with one of his students. Boney unearths evidence of financial troubles and domestic disputes, and a witness states that Amy wanted to purchase a gun. She also finds a medical report indicating that Amy is pregnant, of which Nick denies knowledge, and a diary supposedly written by Amy highlighting her growing isolation, ominously ending with the fear that Nick will kill her.Amy is revealed to be alive and well, having changed her appearance and gone into hiding in a distant campground. Upon learning that Nick was cheating on her, she resolved to punish him by framing him for her murder. Amy plans the framing in great detail: she befriends a pregnant neighbor to steal her urine for the pregnancy test,drains her own blood to leave traces of evidence of murder and fabricates a diary describing her fear of Nick.
|
House Speaker Paul Ryan says it is obvious some people want to harm President Trump, and that he's confident the House Oversight and Government Reform Committee is going to hear from former FBI Director James Comey.
|
using System.ComponentModel.DataAnnotations;
using Microsoft.AspNetCore.Http;
using MVCBlog.Data;
using MVCBlog.Localization;
using MVCBlog.Web.Infrastructure.Paging;
namespace MVCBlog.Web.Models.Administration
{
public class ImagesViewModel
{
public string SearchTerm { get; set; }
public PagedResult<Image> Images { get; set; }
[Required(ErrorMessageResourceName = "Validation_Required", ErrorMessageResourceType = typeof(Resources))]
public IFormFile Image { get; set; }
}
}
|
If this is your first visit, be sure to
check out the FAQ by clicking the
link above. You may have to register
before you can post: click the register link above to proceed. To start viewing messages,
select the forum that you want to visit from the selection below.
Re: Conditional sentences
A: You didn't wake me in time, and I missed the bus.
B: If you missed it, I'm not responsible for that.
Here 'if' has a meaning similar to, 'If you missed it, and I accept that you did'.
Here's a similar usage:
A: I believed every word he said.
B: Well, if you believed everything, you're a bigger fool than I thought you were.
Like many sentences with an if- clause, it's difficult to slot this into the traditional five classes of conditionals, zero, first, second, third and mixed. But then I don't think the traditional five classes are helpful or accurate.
|
Abstract This project will combine molecular dynamics (MD) simulations and other types of molecular mechanics calculations with various experimental methods to characterize the biofilms formed by opportunistic pathogens belonging to the Burkholderia cepacia Complex (BCC). Biofilms are communities of microorganisms where cells are embedded in a macromolecular matrix conferring physico-chemical and biological conditions favorable for cell life. Polysaccharides are primary matrix components contributing to biofilm architecture and function through interactions with themselves and with other biofilm constituents. Biofilms also contain low molecular weight compounds having important biological roles, like signaling (e.g. quorum sensing). Polysaccharides may also interact with these molecules, participating in regulatory mechanisms and impeding the effective action of antibiotics. The primary focus of this project will be on the role of the various exopolysaccharides synthesized by the BCC in the formation and maintenance of biofilms. The aim will be to characterize the biofilms on the molecular level and to thoroughly determine polysaccharide structure and conformations, how they control water and adhere to surfaces, and how their properties depend on structural details. Polysaccharide interactions with biofilm constituents, antibiotics, and potential disaggregating agents will also be investigated. The ultimate objective is to obtain information necessary for rational design of therapeutic agents capable of disrupting biofilms without the use of antibiotics, which can promote resistant strains. BCC bacteria synthesize different exopolysaccharides, both under non-biofilm and biofilm culture conditions. Their specific roles in biofilm architecture are still largely unknown. The proposed experimental studies will characterize the fine structure of biofilm polysaccharides of B. multivorans C1576, their interactions with relevant biofilm compounds and selected antibiotics. In addition, phage display methodology will be used to search for polysaccharide-interacting proteins. The data produced by these experimental studies will provide structural information necessary to construct the starting models for the MD simulations, as well as measurements of properties that can be calculated directly from the MD simulations, providing a test of the validity of the simulation results. The extraordinary molecular-level detail available from MD simulations will yield information about features of biofilm architecture and physical properties that cannot be obtained by other means. The effects of antibiotics and the mechanism of norspermidine, which has known biofilm disruption activity, will also be analyzed in MD simulations as a guide in the design of other therapeutic biofilm disrupting agents.
|
Q:
Windows Azure TDS emulation on a production non-Azure IIS server
I am developing a c# web application that will be hosted in Windows Azure and use Table Data Storage (TDS).
I want to architect my application such that I can also (as an option) deploy the application to a traditional IIS server with some other NoSql back-end. Basically, I want to give my customers the option to either pay me in the software as a service model, OR purchase a license of my application that they can install on a (non-azure) production server of their own.
How can I best architect my data layer and middle tier to achieve both goals?
I will likely need a Windows Azure Worker Role and an Azure Queue. How complicated is to replicate these? Can I substitue a custom Windows Service and some other queuing technology?
How I can the entities in my data model be written such that I can deploy to Azure TDS or some other storage when not deploying to Azure? Would MongoDB or similar be useful for this?
Surely there is a way to architect for Azure without being married to it.
A:
I found a viable solution. I found that I can use EF Code First with SQL Server or SQL CE if I design my entities with the same PartitionKey & RowKey compound key structure that Azure Table Storage requires.
With a little help from Lokad Cloud (http://code.google.com/p/lokad-cloud/) to perform the interaction with Azure Table Storage, I was able to craft a common DataContext that provides crud operations against either EF's DbContext OR Lokad's TableStorageProvider.
I even found a nice way to manage relationships between entities and lazy-load them properly.
The solution is a bit complex and needs more testing. I will blog about it and post the link here when ready.
|
The NAFDAC spokesperson, Dr Abubakar Jimoh, made the disclosure while speaking with the News Agency of Nigeria on Monday in Abuja.
According to Jimoh, the five major products are groundnut, palm oil, sesame seed and beans that were illegally exported to the EU.
He noted that from the information made available to NAFDAC, groundnut was rejected because it contained aflatoxin, which made the quality substandard.
Other banned products
He also noted that exported palm oil did not scale through the EU’s test because it also contained a colouring agent that was carcinogenic.
Jimoh stated that Beans was banned by EU sometime ago but it was illegally exported to European countries.
”Beans was initially banned for one year, when EU was not satisfied with our exported beans in terms of quality assurance, it extended the ban by another two years, which expires next year.
”NAFDAC and other regulatory agencies of the government are working round the clock to ensure that when the ban is lifted, we can then begin to export more agricultural products to EU,” Jimoh, who is also the NAFDAC Director Special Duties, said.
|
- @posted_comments.each do |conference, events|
.panel.panel-default
.panel-heading
%h4.title.panel-title= conference.title
.panel-body
- events.each do |event, comments|
.notifications
%h4.title= link_to event.title, admin_conference_program_event_path(event.program.conference.short_title, event)
%hr
- comments.each do |comment|
%h5.strong Created at: #{comment.created_at}
%p= comment.body
|
Q:
boost read_until does not stop at delimiter
I'm using the boost read_until function to facilitate receiving and parsing HTTP messages over a socket. So what I'm trying to do is read_until from the socket until \r\n, which I think should give me one line of the HTTP header. (Each HTTP header line ends in \r\n, per the standard.) However, what I'm actually getting from read_line instead is the entire header, several lines long. (The header ends in \r\n\r\n, or in other words, a blank line. Also, per the HTTP standard.) Here's a code snippet. sock is the socket file descriptor.
boost::system::error_code err;
io::streambuf request_buff;
io::read_until(sock, request_buff, "\r\n", err); // read request line
if (err)
throw Exception(string("Failed to read HTTP header request line from socket: ") + err.message());
cerr << "Read " << request_buff.size() << " bytes." << endl;
istream request(&request_buff);
try {
request >> m_strMethod >> m_strPath >> m_strHttpVersion;
} catch (std::exception& e) {
throw Exception(string("Failed to parse HTTP header: ") + e.what(), e);
}
if (!request)
throw Exception("Failed to read HTTP header");
if (!alg::istarts_with(m_strHttpVersion, "HTTP/"))
throw Exception(string("Malformed HTTP header: expected HTTP version but got: ") + m_strHttpVersion);
string strTemp;
while (std::getline(request, strTemp))
{
cerr << "Extra line size = " << strTemp.size() << endl;
cerr << "Extra line: '" << strTemp << '\'' << endl;
}
What I expect to see is output indicating it read the number of bytes in the first line of the HTTP message and no "Extra" output. What I get instead is the number of bytes in the entire HTTP header, and a blank extra line (which maybe is because the >> operations didn't consume the newline at the end of the first line) followed by every other line in the header, and another blank line (which indicates the end of the header, as noted above). Why is read_until reading more from the socket than the first line of the header and putting it into request_buff?
Note, I used netcat to receive the request and it's coming through okay. So the HTTP message itself appears to be correctly formatted.
A:
The documentation may seem to imply this:
"This function is used to read data into the specified streambuf
until the streambuf's get area contains the specified delimiter."
But look closer:
until the streambuf's get area contains ...
So, it doesn't promise to stop there. It just promises to return to you as soon as it read the block that contains your delimiter.
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.