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Methods for Screening Live Cells.
Cell screening or, in other words, identification of cells with certain properties is now increasingly used in scientific and medical research, e.g., in diagnostics, drug testing, and production of cell clones with desired characteristics. In this review, we discuss existing methods of cell screening and their classification according to the cell presentation format. We describe the principles of the one-dimensional and two-dimensional formats and compare the main advantages and drawbacks of these formats. The first part describes the methods based on the 2D-format of cell presentation, when cells are immobilized in the same plane by various techniques. The second part describes the methods of the 1D-screening, when cells are aligned in a line in a stream of fluid and scanned one-by-one while passing through a detector. The final part of the review describes the method of high-performance cell analysis based on the merged gel technique. This technique combines the advantages of both 1D and 2D formats and, according to the authors, might become an effective alternative to many modern methods of cell screening. |
The Collaborative R&D Terms and Agreements in Pharma, Biotech and
Diagnostics report provides comprehensive understanding and
unprecedented access to the collaborative R&D deals and agreements
entered into by the worlds leading life science companies.
The report provides a detailed understand and analysis of how and why
companies enter collaborative R&D deals.
Understanding the flexibility of a prospective partner's negotiated
deals terms provides critical insight into the negotiation process in
terms of what you can expect to achieve during the negotiation of terms.
Whilst many smaller companies will be seeking details of the payments
clauses, the devil is in the detail in terms of how payments are
triggered and rights transferred - contract documents provide this
insight where press releases and databases do not.
This report contains links to online copies of actual collaborative R&D
contract documents as submitted to the Securities Exchange Commission by
biopharma companies and their partners.
Contract documents provide the answers to numerous questions about a
prospective partner's flexibility on a wide range of important issues,
many of which will have a significant impact on each party's ability to
derive value from the deal. |
using Amazon.JSII.JsonModel.Api.Request;
using Newtonsoft.Json;
using System;
namespace Amazon.JSII.JsonModel.Api
{
[JsonObject(MemberSerialization = MemberSerialization.OptIn)]
public sealed class Callback
{
public Callback
(
string callbackId,
string? cookie = null,
InvokeRequest? invoke = null,
GetRequest? get = null,
SetRequest? set = null
)
{
CallbackId = callbackId ?? throw new ArgumentNullException(nameof(callbackId));
Cookie = cookie;
Invoke = invoke;
Get = get;
Set = set;
}
[JsonProperty("cbid")]
public string CallbackId { get; }
[JsonProperty("cookie", NullValueHandling = NullValueHandling.Ignore)]
public string? Cookie { get; }
[JsonProperty("invoke", NullValueHandling = NullValueHandling.Ignore)]
public InvokeRequest? Invoke { get; }
[JsonProperty("get", NullValueHandling = NullValueHandling.Ignore)]
public GetRequest? Get { get; }
[JsonProperty("set", NullValueHandling = NullValueHandling.Ignore)]
public SetRequest? Set { get; }
}
} |
It would be appreciated that this invention relates to many different types of crutches or aids that assist in supporting a person from otherwise falling or collapsing. The invention will be discussed with specific reference to crutches, however it will be appreciated that there are a number of combinations of supports, such as a pair of crutches, walking canes or a single crutch.
A crutch holder general comprises a base that supports a hollow vertically extending cylinder for receiving one or more crutches. In order to provide sufficient support, the cylinder typically extends into the air and has a cross section that is suited to retaining the crutch or crutches in an upright position.
It is against this background and the problems and difficulties associated therewith that the present invention has been developed. |
The great news for Castiel on “Supernatural” is that after long hoping that he was going to find a way to get his powers back, the character is going to get precisely what he asked for moving forward. However, this is where we turn to the bad news: He’s not out of the woods just yet. As a matter of fact, him having his abilities back could ultimately mean more trouble for him as he struggles to figure out just what his place in this world is going to be.
Speaking in a new interview to TVLine, showrunner Jeremy Carver does his part to lay out what will be the Castiel crisis moving forward:
“[Castiel will find] himself in the angelic fray more than ever and at a point of decision he never considered a few short months ago. It’s going to be a little of a be-careful-what-you-wish-for [situation].”
On the standpoint of one of the other angels out there, Gadreel is going to find himself in a tricky position now that he has seemingly accepted his position to be Metatron’s new minion-of-sorts. While it may have looked at first like a great idea in theory to be a part of this operation, it is going to end up having much more significant consequences than he first realized. Jared Padalecki is going to be busy throughout the second part of the season, in between trying to tackle this and also touching on the issue of whether or not Sam is still in there.
As for a bonus scoop, there are going to be some beloved characters from the past who turn up again on the show … but Carver is being very tight-lipped on that for now.
If you want to read some more “Supernatural” scoop, then just click here to see what some of the episode titles are going to be moving forward into this season. Also, fly over here to subscribe to our weekly newsletter, and get scoop on all of your favorite TV shows.
Photo: The CW
Love TV? Be sure to like CarterMatt on Facebook for more updates!
|
Demographic
Genre
Media
Nakanishi, delinquent just out of reform school, tries in vain to get free of his past. His new job does not satisfy him and he has to suffer the provocations of his boss. One day, an acquaintance from the net introduces him to a game to help him relieve him of his stress: Duds Hunt.
One rule: no holds barred... |
Chemically Induced Cell Cycle Arrest in Perfusion Cell Culture.
In contrast to most present methods, continuous imaging of live cells would require full automation in each processing step. As an integrated system that would meet all requirements does not exist, we have established a long-term scanning-perfusion platform that: (a) replaces old medium with fresh one, (b) bypasses physical contact with the cell culture during continuous cell growth, (c) provides uninterrupted photomicrography of single cells, and (d) secures near physiological conditions and sterility up to several weeks. The system was validated by synchronizing cells using serum starvation and butyrate-induced cell cycle arrest of HaCaT cells. |
package org.simple.clinic.registration.phone
import com.spotify.mobius.rx2.RxMobius
import com.squareup.inject.assisted.Assisted
import com.squareup.inject.assisted.AssistedInject
import io.reactivex.ObservableTransformer
import io.reactivex.Single
import org.simple.clinic.facility.FacilitySync
import org.simple.clinic.user.OngoingLoginEntry
import org.simple.clinic.user.UserSession
import org.simple.clinic.user.finduser.UserLookup
import org.simple.clinic.util.scheduler.SchedulersProvider
import org.simple.clinic.uuid.UuidGenerator
class RegistrationPhoneEffectHandler @AssistedInject constructor(
@Assisted private val uiActions: RegistrationPhoneUiActions,
private val schedulers: SchedulersProvider,
private val userSession: UserSession,
private val uuidGenerator: UuidGenerator,
private val numberValidator: PhoneNumberValidator,
private val facilitySync: FacilitySync,
private val userLookup: UserLookup
) {
@AssistedInject.Factory
interface Factory {
fun create(uiActions: RegistrationPhoneUiActions): RegistrationPhoneEffectHandler
}
fun build(): ObservableTransformer<RegistrationPhoneEffect, RegistrationPhoneEvent> {
return RxMobius
.subtypeEffectHandler<RegistrationPhoneEffect, RegistrationPhoneEvent>()
.addConsumer(PrefillFields::class.java, { uiActions.preFillUserDetails(it.entry) }, schedulers.ui())
.addTransformer(ValidateEnteredNumber::class.java, validateEnteredPhoneNumber())
.addTransformer(SyncFacilities::class.java, syncFacilities())
.addTransformer(SearchForExistingUser::class.java, findUserByPhoneNumber())
.addConsumer(ShowAccessDeniedScreen::class.java, { uiActions.showAccessDeniedScreen(it.number) }, schedulers.ui())
.addTransformer(CreateUserLocally::class.java, createUserLocally())
.addAction(ProceedToLogin::class.java, uiActions::openLoginPinEntryScreen, schedulers.ui())
.addTransformer(LoadCurrentUserUnauthorizedStatus::class.java, loadCurrentUserUnauthorizedStatus())
.addAction(ShowUserLoggedOutAlert::class.java, uiActions::showLoggedOutOfDeviceDialog, schedulers.ui())
.addConsumer(ContinueRegistration::class.java, { uiActions.openRegistrationNameEntryScreen(it.entry) }, schedulers.ui())
.build()
}
private fun validateEnteredPhoneNumber(): ObservableTransformer<ValidateEnteredNumber, RegistrationPhoneEvent> {
return ObservableTransformer { effects ->
effects
.map { numberValidator.validate(it.number, PhoneNumberValidator.Type.MOBILE) }
.map { EnteredNumberValidated.fromValidateNumberResult(it) }
}
}
private fun syncFacilities(): ObservableTransformer<SyncFacilities, RegistrationPhoneEvent> {
return ObservableTransformer { effects ->
effects
.observeOn(schedulers.io())
.map { facilitySync.pullWithResult() }
.map { FacilitiesSynced.fromFacilityPullResult(it) }
}
}
private fun findUserByPhoneNumber(): ObservableTransformer<SearchForExistingUser, RegistrationPhoneEvent> {
return ObservableTransformer { effects ->
effects
.observeOn(schedulers.io())
.map { userLookup.find(it.number) }
.map { SearchForExistingUserCompleted.fromFindUserResult(it) }
}
}
private fun createUserLocally(): ObservableTransformer<CreateUserLocally, RegistrationPhoneEvent> {
return ObservableTransformer { effects ->
effects
.map {
OngoingLoginEntry(
uuid = it.userUuid,
phoneNumber = it.number,
status = it.status,
capabilities = null
)
}
.flatMapSingle {
userSession
.saveOngoingLoginEntry(it)
.andThen(Single.just(UserCreatedLocally as RegistrationPhoneEvent))
}
}
}
private fun loadCurrentUserUnauthorizedStatus(): ObservableTransformer<LoadCurrentUserUnauthorizedStatus, RegistrationPhoneEvent> {
return ObservableTransformer { effects ->
effects
.flatMapSingle {
userSession
.isUserUnauthorized()
.subscribeOn(schedulers.io())
.firstOrError()
}
.map(::CurrentUserUnauthorizedStatusLoaded)
}
}
}
|
Washington (CNN) White House press secretary Sarah Sanders said chief of staff John Kelly's new security clearance directive will not affect Jared Kushner's work as a top White House staffer.
Sanders declined on Tuesday to get into Kushner's clearance status but said "nothing that has taken place will affect the valuable work Jared is doing."
Kelly said in a statement later Tuesday that he would not comment on security clearances but that he had expressed his confidence in Kushner's ability to "continue performing his duties in his foreign policy portfolio including overseeing our Israeli-Palestinian peace effort and serving as an integral part of our relationship with Mexico."
"Everyone in the White House is grateful for these valuable contributions to furthering the President's agenda. There is no truth to any suggestion otherwise," Kelly's statement said.
Nearly a year into the Trump administration, senior-level staffers -- including Ivanka Trump and Jared Kushner -- remained on interim clearances even as other senior advisers were granted full security access, according to information obtained by CNN from a US government official
Read More |
Production of dynamic lipid bilayers using the reversible thiol-thioester exchange reaction.
Thiol lysolipids undergo thiol-thioester exchange with two phenyl thioester-functionalized tails to produce phospholipid structures that assemble into liposomes with differences in exchange rates, temperature sensitivity, permeability, and continued exchange behavior. This in situ formation reaction imparts dynamic characteristics into the membrane for downstream liposome functionalization and mimics native membrane remodeling. |
Maternal and neonatal infection with coxsackievirus.
Evidence is growing that relates maternal coxsackievirus infection to increased neonatal mortality and an increase of congenital anomalies. Four cases of fulminant perinatal coxsackievirus infections that were fatal to the newborns are presented. Coxsackievirus infections in pregnancy are usually either subclinical or produce minimal symptoms in the mother. The cases presented point out the potential severity of coxsackievirus infections in the neonatal period. Prevention of the disease and isolation of infected individuals are the mainstays of therapy. |
Can I see an ophthalmologist (MD) instead of an optometrist (OD)?
Sightbox does not work with ophthalmologists, who are medical doctors. Ophthalmologists specialize in surgery, infection, and eye disease, although it is within the scope of practice of some ophthalmologists to conduct contact lens exams.
Sightbox works exclusively with optometrists, who focus on eye health and vision correction. An optometrist may be able to provide a referral to an ophthalmologist due to surgical or other eye disease concerns, but please be aware that Sightbox does not pay for any of these services. Please consult your medical insurance for more information. |
Q:
jQuerys wrap function wrap works quite odd
I stumbled over jQuery's wrap() function.
Somehow it behaves different when I'm trying to wrap two div tags which have some text in between them, than without text between the two divs.
jquery:
var wrapper1 = '<div class="wrap1">something in between<div class="innerwrap1">';
$('.content1').wrap(wrapper1);
var wrapper2 = '<div class="wrap2"><div class="innerwrap2">';
$('.content2').wrap(wrapper2);
The resulting HTML is this:
<div class="wrap1">
something in between
<div class="innerwrap1"></div> <!-- wtf? -->
<div class="content1">Lorem</div>
</div>
<div class="wrap2">
<div class="innerwrap2">
<div class="content2">Ipsum</div>
</div>
</div>
Here's a fiddle:
http://jsfiddle.net/RfJN5/
The first result is quite surprising, isn't it? I would think that both closing divs should be placed after .content1, no matter if theres any text between the divs.
Of course I know it's safer to add the closing divs myself to control the behaviour, but is this some kind of bug or just a missunderstanding of how to use jQuery wrap?
Thanks in advance!
A:
that works as expected, your wrapper1 would be the main object that would be wrapped around content1 and as you haven't closed the innerwrapper1, jquery closes it for you. If you want to wrap with inner wrapper then make this an object, wrap content and then append the inner wrapper to wrapper:
var wrapper1 = $('<div class="wrap1">something in between</div>'),
innerWrapper = $('<div class="innerwrap1" />');
$('.content1').wrap(innerWrapper);
wrapper1.append($('.innerwrap1'));
Example
|
The present invention relates to a correcting device for calendar in an analog type electronic watch.
Today, a watch having a calendar mechanism for displaying date and/or day is a very commonly article. In an analog type electronic watch in which time is displayed by pointers by use of the oscillation of the vibrator, such as quartz, such calendar mechanism is also employed. Such calendar mechanism in the watch is adapted to send a date plate on which the letter of the first day through the thirty-first day are printed every one frame per day. According to this mechanism, after the thirtieth day, the thirty-first day is displayed automatically. Therefore, when changing from the end of the even month which have not the thirty-first day to an odd month, it is always necessary to correct the date from the thirty-first day to the first day by operating of the correcting device for the calendar. For this reason, a person using the watch must direct his attention to the end of the even month or the first of the odd month. If he does not correct the date, the date displayed differs from the normal date. In analog type electronic watchs, generally, the operational procedure of a winding stem is set in such a manner that the calendar correcting function can be performed at the second step of the winding stem and reset operation for an electronic circuit can be performed at the third step of the winding stem. Therefore, at the time when the winding stem is pulled out to the second step in order to correct the calendar, due to force beyond the necessary force for pulling out, the winding stem is liable to be pulled out to the third step. As a result of which, there is a danger in which the reset switch is turned on and the watch is stopped.
In the prior art, to prevent such danger and to easily correct the calendar, various correcting device for the calendar have been proposed. However, any proposed correcting device for the calendar is complex in construction and requires many parts so that the cost is high and the volume is large, therefore, this correcting device for calendar is unsuitable for general popular wrist watches.
An object of the present invention is to provide a correcting device for a calendar wherein a calendar correcting operation in an analog type electronic watch can be made automatically, a correcting operation is not required even when changing the month from an even month to an odd month, the above-mentioned danger of stopping the watch by the error-operation of the winding stem can be eliminated, the construction is not complicated and small, and the cost is low. |
As per a recent study by Accenture Analytics, enterprises that are starting upon and completing their Big Data projects successfully, are noting significant value and many practical results from their operations. On the other hand, those standing on the sidelines are finding themselves in a position to be left behind. From innovative market development techniques to new revenue generation, Big data tools and analytics are delivering massive business outcomes for a wide range of strategic corporate goals, and how.
Read on for how Big Data can create wonders or your business and become central to your digital strategy too.
Role of Big Data in Businesses
Big Data—a powerful combination of tools, analytics and processes caters to the ‘data and insights’ needs of an organization. It understands trends, customer preferences, and the target audience of an organization in a big way. If these datasets are properly analyzed and effectively presented, they can help business organizations attain various goals. Additionally Big Data analytics are useful in creating new experiences for figuring out valuable customers and helping services and products create a stronger brand presence for themselves.
Performance of Risk Analysis
Business success is not just dependent on running a company smoothly, there are many other factors in the reckoning too. You need to have a good grasp over the social, economic and all other factors that determine your accomplishments. Predictive analysis—a result of Big Data application in business, allows users to scan and analyze various newspaper reports and social media feeds, and use them too. By helping organizations in different industry verticals perform real time risk analyses; Big Data greatly helps in keeping up with new trends and developments.
Safety of Data
With organizations being bombarded with security specific and other Big Data challenges on a daily basis, it is becoming important for users to install the right tools and techniques for more fluid working. Here, there exist two distinct issues: implementing Big Data techniques for analyzing and predicting security; and securing customers’ and the organization’s information in the context of Big Data. Along with assessing all kinds of internal threats, Big Data tools allow data security experts to map the complete data landscape of their company. The security metrics used by them comply with regulatory requirements, and keep all sensitive information safe.
Creation of more Lucrative and new Revenue Streams
Big Data provides organizations with valuable insights by analyzing consumers and markets alike. The datasets used by organizations are valuable for their stakeholders and all other parties too. For instance, non-personalized trend data held by businesses can be sold to other large-sized industries that are operating in similar sectors.
Dialogues with Customers
Big Data allows business organizations to profile customers who understand their priorities, are smart enough to compare different options, or talk to businesses via social media channels. As a result of the structured and unstructured information provided by Big Data, businesses can engage in one-on-one, real time conversation with consumers. Big Data also impacts with its role in digital and physical shopping spheres. For instance, online retailers are now suggesting offers on mobile carriers and leveraging the benefits of consumer inclines towards escalated social media usage.
Big Data brings the Competitive Advantage
Big Data is allowing many leading organizations to outperform their competition. Established competitors and new entrants are using data-driven strategies in different industries to innovate, capture and compete. From healthcare to IT, Big Data usage is impacting all sectors. Big Data is creating new growth opportunities and giving rise to different categories of businesses, such as those connected with analyzing and aggregating industry data. These days, companies are sitting on large information flows and managing suppliers, buyers, services, consumer preferences, and products in much better ways. Overall, with Big Data best practices in places, organizations are using data more extensively.
Re-Development of Products
Big Data serves as one of the most lucrative ways of using/collecting feedback and understanding how customers perceive an organization’s services and products. By analyzing unstructured social media postings and making all necessary changes, brands are re-developing their products for adding greater value. They are even dissecting the available feedback in line with demographic groups and geographical locations, thereby helping organizations re-design, innovate upon and market their products accordingly. In addition, with the best tools and analytics in place, Big Data is raising the efficiency and productivity levels of varied production processes too.
Way Forward
By the looks of it, there exists little doubt that Big Data will be playing an important role in many different industries across the world and very soon It will be doing wonders for business organizations by making them more efficient, impactful and result-oriented. So, it’s time you started training for Big Data management to reap the many benefits of the same--currently and in future too.
Click Here for Big Data Course |
Marchant Ward
The Marchant Ward is a Brisbane City Council ward covering Alderley, Aspley, Chermside, Chermside West, Geebung, Gordon Park, Grange, Kedron, Lutwyche, Stafford, Stafford Heights and Windsor.
Councillors for Marchant Ward
Results
References
Category:City of Brisbane wards |
Q:
Regex lookaheads (or behinds) matching foo bar or bar foo
I want to match either foo bar baz or bar baz foo. foo can be in either position, but it must be present. I'm not too familiar with lookaheads, and look behinds, but I feel like that's got to be the way to do it. Any tips?
A:
There may be a cleaner way to do this, but the following should work:
/^(?=.*foo)(foo )?bar baz( foo)?$/
http://www.rubular.com/r/7wEVNi5G1Q
Alternatively, you can just use | to match one option or the other:
/foo bar baz|bar baz foo/
|
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Where Do We Go From Here?: Hope and Direction in our Present Crisis
Available Formats
Product Description
The America you thought you knew is gone. No longer is this a nation based on godly principles and morality. America is following its leaders willingly into economic, moral, and political decline. What are Christians to do?
Erwin Lutzer offers hope and a challenge to Christians. It is not time to despair even as we face these difficult realities. Two thousand years of church history are behind us to show that the church does not need freedom or ease in order to be faithful. God's calling on His people can be fulfilled no matter what.
Dr. Lutzer calls Christians to be agents of change in these increasingly secular times, and he offers hope and direction. As the nation morphs, Christians are called to adjust, to be faithful ambassadors for Christ in a country where many are turning away from Him. |
Heuristics in primary care for recognition of unreported vision loss in older people: a technology development study.
To evaluate heuristics (rules of thumb) for recognition of undetected vision loss in older patients in primary care. Vision loss is associated with ageing, and its prevalence is increasing. Visual impairment has a broad impact on health, functioning and well-being. Unrecognised vision loss remains common, and screening interventions have yet to reduce its prevalence. An alternative approach is to enhance practitioners' skills in recognising undetected vision loss, by having a more detailed picture of those who are likely not to act on vision changes, report symptoms or have eye tests. This paper describes a qualitative technology development study to evaluate heuristics for recognition of undetected vision loss in older patients in primary care. Using a previous modelling study, two heuristics in the form of mnemonics were developed to aid pattern recognition and allow general practitioners to identify potential cases of unreported vision loss. These heuristics were then analysed with experts. Findings It was concluded that their implementation in modern general practice was unsuitable and an alternative solution should be sort. |
Q:
IO channels vs reader/writer
Since Go has channels, I was wondering why the standard library doesn't appear to have been designed to use them for IO as well.
There are reader and writer types for that instead but what would be the problem with using channels?
A function could return a channel of byte slices (assuming single-byte, or even single-bit returns are too inefficient) and take in a channel for cancellation requests and a channel for error reporting.
-The curious Go novice.
A:
Channels are a good fit for communicating between goroutines. When a program does something simple, like for example reading stdin, doing something with the stream and outputting the result to stdout - then using a channel is an overkill, unnecessarily hurting performance.
As long as the standard library doesn't provide in some place something specific to goroutines communicating with each other, there's no good reason to model simple operations, like those of io.Reader or io.Writer using channels, respective to have a channel based method set (API).
Additionally, where needed, the simple implementation can be wrapped in a channel, while the opposite, to "unwrap" a channel implementation back to its primitive is not possible. Also, Go authors obviously like explicitness, leading to performance bottlenecks not being hidden (and surprising).
|
Q:
Is Off Trail Travel Between Lakes in the Humphreys Basin, CA Feasible
I'm looking to explore the a number of High Sierra lakes in California's John Muir Wilderness; specifically in Humphreys Basin. Geology (from photographs) appears severe with rock, scree, and debris, Topography appears manageable, and the vegetation appears sparse. The trails move across the North side of the basin and continue out of the area. Inter-lake trails are not denoted on the USGS maps.
Does anyone have any experience bouncing between these lakes in this area? Is the geology and vegetation easy to pass through within the basin?
A:
Absolutely.
I just returned from the area and found that once we crested over Piute Pass and into the Humphreys Basin, the terrain is easily traversable off trail. While the fragile ecology struggling to survive in the rugged windswept mountains may not appreciate traffic from heavy boot-laden steps, access to all of the area lakes, streams, and prominences is easy.
|
Sanchez has quick hands at the
plate, which should allow for some hittability in the future.
Power:
There's power now, but it may not be a
ton as a pro.
Running speed:
Runs better than you'd think.
He's not a clogger.
Base running:
Pretty good baserunner, especially
for a catcher.
Arm strength:
Has a solid-average arm with a
quick release.
Fielding:
Solid catch-and-throw guy behind the
plate.
Range:
Has pretty quick feet and moves pretty
well defensively.
Physical Description:
Sanchez doesn't have a
compact build, but has worked hard to get his body to where it is now.
Medical Update:
Healthy.
Strengths:
Good catch-and-throw skills. Quick
hands at the plate; some power.
Weaknesses:
Body used to be sloppy and he's
worked to get into shape, but he'll have to continue to watch it. Some may ask how a Miami-area catcher got out of
Florida.
Summary:
College catchers are always a premium
commodity and Sanchez has emerged as one of the better options in this year's group. He's a solid catch-and-throw
guy behind the plate, with good overall defensive skills. He also can swing the bat some, with a little power, giving
him an intriguing all-around package. He's struggled with conditioning in the past, but he seemed driven to get
himself into shape. The benefit has been an outstanding junior season that will probably move him off the board early
on Draft day. |
.todo-list ul li.selected { position: relative }
.todo-list ul li span.tab { display: none }
.todo-list ul li.selected span.tab {
display: block;
position: absolute;
width: 100px;
height: 20px;
right: -120px;
top: 10px;
font-size: 50px;
border: none;
color: #d9d9d9;
}
.todo-list ul li.selected span.tab.child-list { right: -130px }
|
Colombo (News 1st) – The National Medical Research Institute has announced that tests have confirmed the four people tested for suspected symptoms of coronavirus were not infected by the coronavirus.
Details to follow… |
Q:
Ace editor trigger event using javascript
Is there anything like
editor.getSession.trigger('change')
the reason I want this is because the editor goes in and out of new, so when It comes back into view I need it to do its normal 'change' thing, but I dont want to wait for user input?
Currently I have
editor.getSession().on('change', function(){
editorChangeHandler()
})
and I just recall
editorChangeHandler()
when I need to, but editor.getSession.trigger('change') is much nicer.
A:
editor.session._emit('change') would trigger editorChangeHandler, but fake change event will break undo history.
|
This invention relates to an envelope having a supplemental flap that can be written upon to provide pertinent messages.
This invention is a simple and efficient means of improving the way people look at and handle the everyday chores of messaging in the work place, at home, and in all industrial, commercial, and private sectors.
This invention is nothing more than an additional flap applied to either custom-designed or existing standard stationary envelopes to make them readily available for easy use. This invention not only permits multiple reuse of the envelope, but also provides a constant reminder of importance until it is submitted via either postal, courier, or any other means of delivery. What makes this invention unique is the manner in which it makes the user aware of its presence by hanging where it will be most noticed. This is achieved by having an adhesive that is re-sealable, or one that releases when needed, but not limited to the adhesive type or quality available already on the market. In this way, time and efficiency will greatly be enhanced, since time lost looking for items to send will now be in plain sight.
This invention comes in variations, including one with a perforated edge for ease of removal, thus creating an instant ticker or receipt, and another with an add-on flap which can be attached to any plastic, paper, or synthetic material. The manner in which this invention is employed will vary depending on the environmental setting. In the office, this invention will initially be used in the xe2x80x9cadd-onxe2x80x9d mode using a suitable dispenser to retro-fit supplies, until office stationary is exhausted, after which custom-designed envelopes and other containers can be supplied. This applies to the other environmental settings as well. In the add-on mode, may be made in numerous style adaptations, including but not limited to color, size, and material.
In the commercial market, this invention allows many, if not all of the common carriers, to replace the existing messaging instruments. It will make dropping off customer letters much more convenient for the courier by giving them the means to affix the letter, or small parcel to the customers door, instead of leaving it shoved in the door knob, or simply left on the floor.
This invention may be constructed of various materials, including paper, metal, all natural, and synthetic substances. The size will vary to accommodate the various designs of stationary already existing on the market. The exact dimensions of the invention may change due to the differences in existing stationary. It is because of this that dimensions have intentionally been omitted, but this does not in anyway limit the overall design, or concept of the invention. The add-on flap""s dimensions will change due to the ever-changing supply of custom and standard stationary. However, the flap will have sufficient flap space to allow the user to make notes, or enter in any medium they feel fit, and will be durable enough to allow such entry. The lower portion will have an adhesive that sufficiently adheres to the product, but will as an option release and readhere; some will be more permanent than others. The invention, once attached, provides a surface to attach the two to a variety of areas, and provide a message reminder of the event. On the reverse side, the resealable flap of this invention has adhesive at the upper edge in sufficient quantity to allow for temporary or permanent attachment. To efficiently dispense the invention, a suitable dispenser may be provided. In the manufacture of custom made envelopes, a resealable flap of this invention may be incorporated into the standard stationary design by simply adding an additional flap to the backside of the envelope. This may be accomplished by using adhesives and folds pressed during manufacturing that will combine the flap of this invention into a traditional style stationary. The type of adhesive, manufacturing specifications, and are not limited in kind since variations in standard and custom stationary are ever changing. The sole essence of the invention contends that the basic elements remain, which are a flap, that can attach, or can be attached, to stationary, and has an adhesive that can then attach the stationary to many different things where it can be viewed in conspicuous places. |
Antimicrobial activities of microbial strains isolated from soil of stressed ecological niches of Eastern Uttar Pradesh, India.
Antimicrobial activities of twenty bacterial strains isolated from ten different stressed agro-ecological niches of Eastern Uttar Pradesh, India were evaluated against bacteria, yeasts and molds. Eleven isolates showing strong antimicrobial activities were characterized. Eight antifungal compounds were purified and partially characterized by Ultra-Violet (UV) absorption spectra and grouped into polyenes and non-polyenes. Antibacterial metabolites produced by four isolates were purified and chemically characterized, of which one isolate (AB) produced a new form of olivanic acid, and other three isolates (C5, Py and M4) produced antibacterial compounds having phenoxazone nucleus. |
A Compassionate, College-Prep Community
A Compassionate, College Prep Community
Our Mission
The mission of North Lawndale College Preparatory Charter High School (NLCP) is to prepare young people from under-resourced communities for graduation from high school with the academic skills and personal resilience necessary for successful completion of college. |
The role of melanocortins and their receptors in inflammatory processes, nerve regeneration and nociception.
The melanocortins are a family of bioactive peptides derived from proopiomelanocortin. Those peptides, included among hormones and comprising ACTH, alpha-MSH, beta-MSH and gamma-MSH, are best known mainly for their physiological effects, such as the control of skin pigmentation by alpha-MSH, and ACTH effects on pigmentation and steroidogenesis. Melanocortins are released in various sites in the central nervous system and in peripheral tissues, and participate in the regulation of multiple physiological functions. They are involved in grooming behavior, food intake and thermoregulation processes, and can also modulate the response of the immune system in inflammatory states. Research of the past decade provided evidence that melanocortins could elicit their diverse biological effects by binding to a distinct family of G protein-coupled receptors with seven transmembrane domains. To date, five melanocortin receptor genes have been cloned and characterized. Those receptors differ in their tissue distribution and in their ability to recognize various melanocortins. These advances have opened up new horizons for exploring the significance of melanocortins, their ligands and their receptors for a variety of important physiological functions. We reviewed the origin of MSH peptides, the function and distribution of melanocortin receptors and their endogenous and exogenous ligands and the role of melanocortins and their receptors in inflammatory processes, nerve regeneration and nociception. Moreover, we analyzed their interaction with opioid peptides and finally, we discussed the postulated role of the melanocortin system in pain transmission at the spinal cord level. |
[Asymptomatic proteinuria in children].
Asymptomatic proteinuria is a common finding in primary care practice. Most children with asymptomatic proteinuria, diagnosed at screening urinalysis, do not have kidney disease. When proteinuria is detected, it is important to determine whether it is transient, orthostatic or persistent. Transient proteinuria is most often associated with fever, exercise or stress and it resolves on urine testing when the cause is withdrawn. Orthostatic proteinuria is a benign and common condition in school-age children. Persistent proteinuria should be carefully evaluated because it is a marker of renal damage and associated with kidney disease. It is not necessary to extensively investigate all children found to have proteinuria. Children with persistent proteinuria should be referred to a pediatric nephrologist to get a diagnosis and start treatment when necessary. |
MINKANAK pussycat panties
What do your panties say about you? Make it "stylish, brave - and super-fun"! And what better way to say it than with PUSSYCAT PANTS! |
Eternal Sunshine of the Spotless Mind
Eternal Sunshine of the Spotless Mind holds a place in my heart much like Lost In Translation, which I discussed a few weeks ago — which is to say I cry every time I watch it. The best part of Eternal Sunshine is that it is completely truthful in terms |
canvas {
background-color: #cccccb;
}
html {
-moz-user-select: none;
-khtml-user-select: none;
-webkit-user-select: none;
user-select: none;
} |
The present invention relates generally to deadlock avoidance in a bus fabric, and more particularly to deadlock avoidance at an interface between integrated circuits.
Few applications stress the resources of a computer systems to the extent that video does. Video capture, encoding, and the like involve huge transfers of data between various circuits in a computer system, for example, between video-capture cards, central processing units, graphics processors, systems memories, and other circuits.
Typically, this data is moved over various buses, such as PCI buses, HyperTransport™ buses, and the like, both on and between the integrated circuits that form the computer system. Often, first-in-first-out memories (FIFOs) are used to isolate these circuits from one another, and to reduce the timing constraints of data transfers between them.
But these FIFOs consume expensive integrated circuit die area and power. Accordingly, it is desirable to limit the depth of the FIFOs. Unfortunately, this means that these FIFOs may become filled and not able to accept further inputs, thus limiting system performance.
It is particularly problematic if these filled FIFOs are in a data path that forms a loop. In that case, there may be a processor, such as a graphics processor, or other circuit in the loop that becomes deadlocked, that is, unable to either receive or transmit data.
This can happen under the following conditions, for example. A first FIFO that receives data from a circuit cannot receive data because it is full. The first FIFO cannot send data to a second FIFO because the second FIFO is also full. The second FIFO similarly cannot send data because it wants to send the data to the circuit, which cannot accept it since it is waiting to send data to the first FIFO. This unfortunate set of circumstances can result in a stable, deadlocked condition.
Thus, what is needed are circuits, methods, and apparatus for avoiding these deadlocked conditions. While it may alleviate some deadlocked conditions to increase the size of the FIFOs, again there is an associated cost in terms of die area and power, and the possibility remains that an even deeper FIFO may fill. Thus, it is desirable that these circuits, methods, and apparatus not rely solely on making these FIFOs deeper and be of limited complexity. |
Table of Contents
Key Binds
Modifier Characters
Modifiers are special characters that can alter the use of a keybind. They can change a bind from being a single press of, for example F1, to requiring a special key to be pressed as well such as CTRL, ALT, Shift, etc.
Ashita supports the following modifier keys:
! - represents ALT key requirement.
^ - represents CTRL key requirement.
@ - represents Windows key requirement.
# - represents Apps key requirement.
+ - represents Shift key requirement.
Note that not all keyboards can support pressing multiple key combinations at once. Not all keyboards support high key count ghosting.
Bindable Keys
Below is a list of valid keys to use with Ashita's key binding system. |
Metathermotics: Nonlinear thermal responses of core-shell metamaterials.
Thermal metamaterials based on core-shell structures have aroused wide research interest, e.g., in thermal cloaks. However, almost all the relevant studies only discuss linear materials whose thermal conductivities are temperature-independent constants. Nonlinear materials (whose thermal conductivities depend on temperatures) have seldom been touched; however, they are important in practical applications. This situation largely results from the lack of a general theoretical framework for handling such nonlinear problems. Here we study the nonlinear responses of thermal metamaterials with a core-shell structure in two or three dimensions. By calculating the effective thermal conductivity, we derive the nonlinear modulation of a nonlinear core. Furthermore, we reveal two thermal coupling conditions, under which this nonlinear modulation can be efficiently manipulated. In particular, we reveal the phenomenon of nonlinearity enhancement. Then this theory helps us to design a kind of intelligent thermal transparency devices, which can respond to the direction of thermal fields. The theoretical results and finite-element simulations agree well with each other. This work not only offers a different mechanism to achieve nonlinearity modulation and enhancement in thermotics, but also suggests potential applications in thermal management, including illusion. |
Rural surgery: the North Dakota experience.
Surgeon availability is a problem for small and isolated rural areas. Unless the supply of surgeons trained for rural areas increases, patient care will be jeopardized. Nationally, a diminishing number of graduating residents opt for careers in general surgery. This crisis is unrecognized or ignored by major teaching programs. This article describes a program at the University of North Dakota that allows exposure to surgical specialties by incorporating them into the general surgical services. It concludes that distinct training for urban and rural general surgeons must be recognized; and general surgery programs should be allowed to be innovative and not penalized for adjusting their programs to allow residents to train for rural and community sites. |
Q:
PERL: repeated lines
I'm writing a perl code that print a massage/send a mail if there is a repeated line found in a file.
My code so far:
#!/usr/bin/perl
use strict;
my %prv_line;
open(FILE, "somefile") || die "$!";
while(<FILE>){
if($prv_line{$_}){
$prv_line{$_}++;
}
#my problem: print I saw this line X times
}
close FILE
My problem: How do generate a static msg with output: print "I saw this line X times" without printing the script output
Thanks
A:
Your original code is very close. Well done for use strict and putting $! in the die string. You should also always use warnings, use the three-parameter form of open, and use lexical file handles.
This program should help you.
use strict;
use warnings;
my %prv_line;
open (my $FILE, '<', 'somefile') || die $!;
while (<$FILE>) {
if ( $prv_line{$_} ) {
print "I saw this line $prv_line{$_} times\n";
}
$prv_line{$_}++;
}
|
Commercial Insurance
Who Needs Business Insurance?
The right insurance is an important tool to protect any business. Let your broker help you plan and arrange the right insurance for your business. Anyone operating a business, whether it’s home-based, a large industrial operation or a professional services offi ce, needs commercial insurance as part of an overall risk management strategy…Continue Reading
What Extra Coverage Should I Be Aware Of?
Special policies can cover the risks unique to your business. These are just a few of the special coverages available for special situations, your broker can tell you more…Continue Reading
How Can I Reduce The Risk In My Business?
A risk management program is the best way to systematically reduce the impact of risk. Your commercial insurance broker has the experience to help you manage the insurance risks in your business. An experienced commercial broker knows how to identify and manage many of the risk factors in your business and translate that knowledge into a cost-effective risk management program…Continue Reading |
Q:
Is it possible to have local aliases for branches?
My workplace uses YouTrack ticket names as branch names (e.g. MD-####). However this can look a bit factory-like in my Git desktop client and makes extra steps when returning to previously blocked work, etc.
Can i give my branches descriptive names locally for my sanity but not change the branch name on the repo?
Thanks in advance
A:
Yes, your local branches do not need to have the same name as their corresponding remote branches. More generally, your local branches can define an upstream branch.
Let's say you are interacting with a remote branch MD123 but a better semantic name for it would be nullPointerFix.
You can create your local branch with the semantic name: git checkout -b nullPointerFix and then set it's upstream branch as MD123: git branch -u origin/MD123.
Now, as you work on your semantically named local branch, you can git push and git pull from the remote branch.
|
A small powerhead? What kind? I think I'd like that better than this air-pump driven method. It just seems weak to me but at the same time, it is gentle for the PFR and I don't know if a powerhead would create too much current for shrimp. |
Q:
Generate cloudformation for exisiting resouces, load balancer migration
I was wondering if anybody has had any experience creating a cloudformation template from exisiting AWS resources.
I am currently trying to migrate from a classic elb to a alb using the wizard. However I already have cloudformation templates managed by github. Therefore I would need to add the alb in after it has been created. I tried using cloudformer but it doesn't appear to support alb whereas it does pickup classic.
Has anybody had experience migrating elbs and creating cloudformation templates from existing resources?
Many thanks!
A:
AWS::ElasticLoadBalancingV2::LoadBalancer is one of the resources that can be imported into CloudForamtion. But sadly AWS::ElasticLoadBalancingV2::TargetGroup can't be imported.
Importing is a try-and-see operation. It is not automated as many people expect it to be. The reason is that you have to manually create the template for the resources being imported. What's more, the attributes of the resources in the template created must match exactly existing resources.
CloudFormer is not helpful these days. Its not maintained by AWS anymore and has been in beta for years.
If you haven't tried importing anything before, the best way would be to start with AWS tutorial: Importing Existing Resources Into a Stack
This way you can start with something simple, before you move to ALB with all its listeners and listener rules. Off course you have to create new Target Group as well as it can't be imported sadly.
|
Caribou Ministries is dedicated to helping men who are lost in the dark world of sexual immorality through recovery coaching. Pornography, adultery, and sexual addiction have become them enemy's greatest weapons against us.
In Swahili there are many words for Welcome. Caribou is a special welcome used at night while camped around a fire when someone approaches from the darkness. It means you are welcome to come out of the darkness and into the light.
Our Mission
The guilt and the shame leave men with little recourse. Our mission is to provide hope, recovery, and healing for those with nowhere else to go, for those who are lost in the dark. To those men we say "Caribou."
Hope is like the sun, which, as we journey toward it, casts the shadow of our burden behind us.
— Samuel Smiles
WE Help men who are:
Grappling with how to handle their wife's trauma, anger, and other intense emotions |
Computing centers such as data centers generally include a large number of computing devices. The computing devices can include, for example, servers, switches, routers, storage systems, and the like. A rack may provide a standardized structure to support and mount the computing devices. A power distribution unit (PDU) can also be mounted on the rack to provide electrical power to the computing devices. |
Køb Canada Goose Dunjakke When young
Køb Canada Goose Dunjakke When youngKøb Canada Goose Dunjakke time, energy, no money. Middle age: energetic, rich, no time. Old age: time, money, no energy. Where did these words come from, who said, I have long forgotten, forgotten completely. In my opinion, forgotten is for their own tolerance, forgetting is a beauty. So, I forgot.
Canada Goose Dunjakke butik Find Canada Goose Jakke Salg a corner squat down, watching the crowds of people from the street, involuntarily smiled, helpless, take the time to get the money when young, old age, but money to life. Is this a human life? With youth earn money, but can not buy youth, perhaps this is the biggest sadness in life. Please do not let money cover your eyes to see the world.
When we were born, we knew nothing about it, and we could not help but cry. It seems that tears are omnipotent, she can make us no longer hungry, Canada Goose Herre Jakker she can drive us out of the cold, she can make our body healthy. Until the weeping year, the age of cardamom, we are accustomed to cry, a little unhappy, let the cheap tears endless flow.At this point we have our own ideas, though we have not yet reached autonomy, but we already know what we want. Seeing the zero-sum will not open step, see the toys, eyes that yearning has been lingering toys and adult face. At this point we are simple, simply put everything written on his face, simply we have a naive face, people can not bear to deceive, not cheating, the world of childhood there is no lies and deception.
Age after childhood seems to understand some of the emotions have nothing to do with themselves, this emotion gives us the pressure. The mind is immature. We are under pressure and expectation to walk like a headless flies Canada Goose Dame Jakke in this world, only we do not know where is the front. Seems to be accustomed to childhood without fear, at this time we still allow ourselves to indulge, no matter how much time wasting, no matter how many Tim empty years, we are still self-willed indulgence. Until the external factors and their own concepts have an unmanifiable conflict, we have trouble, in trouble we have learned to think. Contemplate yesterday, consider the present, consider tomorrow. Just the frontal cortex seems unable to secure the right hand |
Folding knives typically include a handle and a blade that pivots relative to an end of the handle. When the blade is not being used, the blade is usually pivoted to a retracted position where the cutting edge of the blade is disposed in a slot in the handle. When the blade is being used, the blade is usually pivoted to an extended position where the cutting edge of the blade is exposed. Most folding knives also include a locking mechanism to lock the blade in the extended position. The locking mechanism primarily protects a user's fingers by preventing the unintentional retraction of the blade during use.
A typical locking mechanism includes a notch or flat surface near the pivot axis of the blade that is typically engaged by a bolt or catch to prevent the blade from pivoting. Unfortunately, due to the short distance typically provided between the pivot axis and the notch, a given torque, when applied to a blade that is locked, will create substantial forces on the locking mechanism thereby causing the mechanism to loosen, wear, or fail.
Furthermore, because the blade is typically fixed to the handle at only two points when locked (the pivot axis and the notch), the blade is susceptible to wobble and play when lateral or torsional forces are applied. As the mechanism wears, the blade becomes more susceptible to wobble and play.
In part because of the limitations described above, current folding knives are often too weak to withstand substantial force, and a rigid, one-piece knife must be used. However, one-piece knives require the use of a scabbard for safety, and the knife may not be converted to a more compact form for storage.
In view of the above, there is a need for improved folding knives and related methods that provide improved locking and better blade stability. |
Q:
Finding the most frequent committer to a specific file
Given a specific file in a git repository, how would I go about finding who are the most frequent committers in that file?
A:
You can use git shortlog for this:
git shortlog -sn -- path/to/file
This will print out a list of authors for the path, ordered and prefixed by the commit count.
Usually, this command is used to get a quick summary of changes, e.g. to generate a changelog. With -s, the change summaries are suppressed, leaving only the author names. And paired with -n, the output is sorted by the the commit count.
Of course, instead of the path to a file, you can also use a path to a directory to look at the commits to that path instead. And if you leave off the path completely, git shortlog -sn gives you statistics for the whole repository.
|
Ocular Munchausen's syndrome.
Patients with contrived histories and/or self-induced physical abnormalities (Munchausen's syndrome) are often successful in deceiving physicians. We recently cared for four patients with ocular Munchausen's syndrome. Self-induced ocular manifestations included voluntary nystagmus, subconjunctival hemorrhages, chronic orbital emphysema requiring exenteration, corneal alkali burns, erosions and ulcerations, and abscesses of the periorbital area. Correct diagnoses of ocular Munchausen's syndrome were made only after extensive medical and surgical investigations. Suggestions for evaluation and treatment will also be discussed. |
Q:
Ways to make your WCF services compatible with non-.NET consumers
I'm working on adding a WCF services layer to my existing .NET application. This layer will be hosted in IIS and will be consumed by a variety of UIs, at least one of which will not use Microsoft technologies.
I can make a Web service in WCF that is consumed by my .NET application. However, I'm concerned about things that work in the .NET world but not with other technologies.
For example, simply throwing an exception from my WCF service works fine in .NET. But according to this article, one should approach exception handling with fault contracts to ensure compatibility with non-.NET consumers. The author labels this lack of foresight as The Fallacy of the .NET-Only World.
Does anyone have any high level suggestions or links to articles that cover interoperability between WCF and non-.NET consumers?
I realize I'm potentially working against the YAGNI principle. I'm only really looking to avoid things that will be incredibly difficult to overcome later when the developers of the non-.NET consumer report problems to me.
A:
use any of the WCF bindings that don't start with net - avoid netTcp, netMsmq etc. - those are .NET only
make sure to make good use of DataContract/DataMember attributes, so that your method input and return parameters are easily and nicely serialized
avoid any .NET specific types in your data contracts - don't pass back an Exception or something like that - use the SOAP (or REST) elements for those things instead
don't use things like DataSet, DataTable etc. - they're all heavily tied to .NET
make sure to properly catch all errors on your service side - e.g. by implementing IErrorHandler - and pass back SOAP faults instead (if you're using a SOAP binding) or a HTTP error code (for REST)
TEST your services with non-.NET clients! Run a PHP page against them, code up something in Ruby - whatever - test it and make sure it works
|
"Okay." Matt said, distracted by a group of girls in very tight, very low cut shirts.
Making his way out of the crowd slowly he thought about the curly haired girl from his high school.
He truly didn't know why he had the girl on his mind still. He hadn't really talk to her that much even when they were in school together. He only saw her in the halls but there was just something about her though. Matt was right though, he hadn't seen her since graduation two-days after school got out, but she still hadn't left his mind all through the summer.
After making his way around a table and a couple of kegs he finally made it to the door and out. There wasn't that many people outside. It was mid-October but the weather was still summery. It was chillier but it was still nice enough to sit outside for a long while. Austin had somewhat of headache and slight buzz going on. Looking around the different dorm buildings he saw a grassy courtyard. Instead of leaving he decided he would just lay down in the grass to cool down.
As he made his way into the courtyard entrance he found he wasn't the only one with the same idea. As he neared to person he came to realize that it was a she and she was laying on her back looking up at the stars. As he came closer to the girl she sat up and turned around to see who was approaching her. Through the moonlight and the party lights he recognized the girl immediately. It was her. The same curly haired, green-eyed girl that consumed his thoughts from last school year until now.
She looked almost the same. But her hair was lighter and longer. It was even curlier if that was even possible. But she still had those same large gorgeous green eyes.
As Austin stopped in front of her, she squinted her eyes and scrunched up her face in thought.
"Do we know each other?" She asked.
The author would like to thank you for your continued support. Your review has been posted. |
Owner Message
The Heritage Club at Aurora located in Aurora, Colorado offers Personalized Assisted Living and Alzheimer's and Dementia Care options for seniors. Our community is designed to help those who need assistance with daily activities such as bathing, dressing and administering needed medication. Just like family, we provide the extra assistance you may need with your daily activities, while helping you maintain the privacy, dignity and independence that means so much to you. And we do it all in a family-centered environment where loved ones are encouraged to be as involved as possible. Our award-winning ConnectedLiving program helps residents stay connected online with family and friends. In addition, residents’ family members are able to access the ConnectedLiving Network (CLN) from anywhere to communicate directly with their loved one and view dining menus, calendars, photo galleries and more. At the Heritage Club you will be served by an exceptional, dedicated and caring professional staff who genuinely love what they do. As a resident, you'll enjoy a friendly environment where common living areas, an inviting dining room and a warm kitchen naturally draw people together. In your beautiful apartment, you will enjoy all the comforts of home. And with the addition of your personal furniture and cherished possessions, it's sure to be an even brighter place. You will enjoy three home-style meals a day and may take part in as many of our social and recreational activities as you choose. Whether sharing delicious meals with friends and family, taking advantage of the many wonderful activities available, or simply relaxing in the privacy of your apartment, the lifestyle at the Heritage Club offers everything you need to get the very best out of life. We invite you to come experience exceptional senior living at the Heritage Club today. REQUEST INFORMATION on assisted living communities by clicking on the BUTTON below.
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From family friendly trips with kid friendly activities to local plumbers lawyers, spas, and contractors. Judy’s Book has millions of listings and reviews for the best and not so great. Whether you’re looking for a specific business or just trying to discover great places we make it easy. We’re a family oriented site focusing on bringing trusted reviews and recommendations to moms and others. Green and Sustainable places are becoming more relevant to Judy’s Book users, have a favorite place? Write a review and tell users why it’s Green! |
How to Keep Critters Out of Your Crawl Spaces
The weather is finally cooling down, which is great! But as it gets chillier outside, you may find that your family members aren’t the only ones retreating into your home. That’s right–pests will happily invade your indoor spaces for shelter during the colder months. How can you keep them away from your attics, closets, and crawl spaces?
Declutter. Rodents in particular love to live in your junk. The less junk you have, the fewer places they have to hide. Get rid of clutter and be ruthless!
Take Out the Trash. Pests aren’t picky! The less trash there is in your home, the less pests have to eat. Take out the trash regularly and keep indoor trash cans carefully sealed. Use bungee cords if necessary. Don’t put anything past rodents!
Call an Exterminator. By the time you see rodents, your pest problem is well advanced. The signs of pests are also signs that you should call a professional.
Declutter Again!Did you really declutter last time? Do it once more, just in case. Cleaning out the attic, the crawl space, the closets, and even the drawers in your home will go a long way towards dissuading pests.
With a little extra work, you can make your home comfortable for your family, but not for mice, rats, and bugs. Don’t forget to callMr. Junk in Metro Atlanta to haul away your unwanted stuff so they have nowhere to hide! |
How To Decorate Using Tropical Outdoor Metal Wall Art
How To Decorate Using Tropical Outdoor Metal Wall Art – Do you talk about rust ? Rust is an enemy for every single metal wall decor. It is especially for your outdoor like metal wall decor? If yes, you need to consider about make it to your outdoor decoration. Have you ever imagine how difficult it is? Metal is one of material that vulnerable with damage. We can space. So, you need to consider about your wish for using metal wall decor.
Metal wall decor usually is used for indoor. Metal is really liked because metal really suitable in every place. And about the treatment is really easy too. Metal is really strong for putting in many things above it. We can understand about many necessities for metal wall décor. It is especially for man home. Man is really like something that functional and strong at the same time. Metal wall décor give it.
If you keep want to use metal wall décor for your outdoor, you need to know about how makes your metal wall décor keep good for a long time. Perhaps, you can find out about technique to make it long lasting. If you do not have any ways, you can ask the expert decorator. They usually understand about furniture sets. They can give you advise about metal decoration that can long lasting and not. You can ask their professional opinions about it.
If they can give you the solutions how keep metal wall decor good, you can continue it. If not, you need to consider again. Or, you can combine your metal wall décor with other materials that are almost same with metal. We can choose stainless steel or wood. And every element can be colored same. For example we can be coloring every decoration with white color. So, metal or not cannot be divided. |
{
"domain": "input_boolean",
"name": "Input Boolean",
"documentation": "https://www.home-assistant.io/integrations/input_boolean",
"codeowners": ["@home-assistant/core"],
"quality_scale": "internal"
}
|
“No, John. After the Time War and all the freejackings and Doctor Gary selling the White House on Craigslist and Philly getting destroyed, I was impeached.”
“It’s been two days.”
“It was an open-and-shut case, John.”
“Sure. Well, either way: I’m sorry. How you taking it?”
“I’m at Burning Man.”
“Of course you are.”
“Once again, I have returned to my ancestral home, which is an ultra-RV in a field they used to test nukes in.”
“Can’t you just take drugs at home like the rest of us?”
“John, Burning Man is about so much more than taking drugs: it’s about art on drugs, and sex on drugs, and freedom. Drug-related freedom, but still freedom. There’s a lot of drugs, yeah.”
“How’s Doctor Gary?”
“Busy!”
“I would assume.”
“He made a new drug, John. Blackrock for Black Rock. It’s Glyco-Morphohexahydrobenzoylmethylecgonine.”
“Is that spelled right?”
“I have no idea.”
“What is it?”
“Speedball, but you vape it.”
“Wow, did the world not need that to be invented.”
“Selling like hotcakes, John. Also selling well are Hotcakes, which are waffles in a psilocybin/fentanyl syrup.”
“Where is Doctor Gary making all this stuff in the middle of the desert?”
“He stole a couple mobile labs from the CDC when I made him the boss over there.”
“Sure. So: Katy Perry is a Burner.”
“Oh no. I’m with Hillary, John.”
“BurnER.”
“I’m a hunka hunka Burning love, John. I am cleansed by the wind of the Playa. The dust scours the world from me, and the sun bleaches my bones of sin. If only all the world could be at Burning Man, John, then there would be no war. No strife. Just love, and sand, and drugs.” |
What Do Different Menstrual Blood Colours Mean?
Menstrual cycles are a monthly occurrence that usually lasts for about a week. A host of problems is usually associated with the period, including headaches, stomach pain and heavy cramps. Everyone who gets their period knows very well that while there are some symptoms they suffer every month, periods can differ from month to month. One of the things that can be different is the colour of menstrual blood. Most often, as the blood flows quickly from the body, it will be red or pink in colour. However, darker shades, such as brown or black, can also occur. According to experts, this simply means that the blood flows slower. If you don’t know this, however, it may be the cause of a lot of worries.
It is quite normal for blood to have different colours throughout the period, being sometimes lighter, sometimes darker. It is good to know what certain colours indicate, so that all unnecessary worry may be avoided, but also so that potential problems might be spotted in time.
Pink
Pink is a normal shade for the early stages of a period. Should it appear in the middle of the cycle, it may a hormonal disorder, some disease of the reproductive tract or even early pregnancy. If this happens, it is best to visit a gynaecologist.
Bright
The blood is bright when it flows quickly out of the body, not having any time to darken. It usually happens after a busy day and the flow is light. This is entirely normal and is no cause for worry. Should it continue for longer than a week and the blood turns pink, it is a sign of a problem.
Dark red
A darker shade of red is completely normal for a cycle, usually occurring in the middle days. However, if the colour doesn’t lighten and there is much more blood than usual, it may signal a miscarriage or the possibility of a tumour.
Orange-red
This shade is quite uncommon for a period. When period blood turns this orange-red, it is often followed by an unusual odour too. A visit to a gynaecologist, in this case, is a must. The blood may turn this shade because of mixing with fluids from the cervix, or it may point to a host of different infections.
Brown – black
This is another quite common occurrence in period blood. While it may look alarming, a flow with a darker shade means that the blood was in the uterus for a longer time. This sort of colour is often seen in the morning. It is harmless and shouldn’t raise any alarms. If however, it is accompanied by a yellowish colour in the blood too, then it may be a sign of an infection.
Heavy bleeding
A stronger, heavier flow usually happens in the second or third day of the period. It is normal and experienced by most.
On the other hand, if there are only small traces of blood, if the period is very late or doesn’t happen at all, then a visit to the gynaecologist is in order. This may indicate early pregnancy or a hormonal disorder. |
The use of food service containers is known in the prior art. These containers may be primarily configured to dispense food while maintaining the food at desired temperatures. These containers are primarily utilized in institutional and commercial settings and are configured with a plurality of containers that keep cold foods cold and hot foods hot. While they excel at storing and dispensing food at desired temperatures, a food service worker is typically employed to dispense the food because the containers and manner of dispensing inevitably results in an aesthetically unpleasing food presentation. These containers also prohibit storing foods with a higher temperature in close proximity to foods with a lower temperature.
Other food service containers are primarily configured to display food in an aesthetically pleasing manner. These containers may be utilize lights and motorized sections in order to present the food in an artful and appetizing display, however they are unable to maintain the desired serving temperature of the food. This results in the need for food service workers to closely monitor the temperature of the food and ultimately in a shortened duration for food display. These containers also prohibit storing foods with a higher temperature in close proximity to foods with a lower temperature.
Recently, food service containers have become available that are capable of storing and dispensing food at desired temperatures while doing so in an aesthetically pleasing manner. These containers may be configured to display foods while requiring foods with like serving temperatures to be sequestered from foods with different serving temperatures. This frequently results in the need for multiple food service containers and limits the food positioning and displaying options.
Therefore a need exists for a food conveying container that is able to maintain and dispense food at desired temperatures. A further need exists for a food conveying container system that is able to maintain a plurality of different temperature food items in close proximity to one another. Finally, there is a need for a novel food container that is able to convey and display temperature regulated food in an aesthetically pleasing manner. |
import { NgModule, ValueProvider } from '@angular/core';
import { CommonModule } from '@angular/common';
import { LayerDirective, LayersDirective } from './layers.directive';
import { CustomCursorDirective, CustomCursorsDirective } from './customcursor.directive';
import { ConnectorAnnotationDirective, ConnectorAnnotationsDirective } from './connector-annotation.directive';
import { ConnectorDirective, ConnectorsDirective } from './connectors.directive';
import { NodeAnnotationDirective, NodeAnnotationsDirective } from './node-annotation.directive';
import { PortDirective, PortsDirective } from './ports.directive';
import { NodeDirective, NodesDirective } from './nodes.directive';
import { DiagramComponent } from './diagram.component';
import { DiagramModule } from './diagram.module';
import {HierarchicalTree, MindMap, RadialTree, ComplexHierarchicalTree, DataBinding, Snapping, PrintAndExport, BpmnDiagrams, SymmetricLayout, ConnectorBridging, UndoRedo, LayoutAnimation, DiagramContextMenu, LineRouting, ConnectorEditing} from '@syncfusion/ej2-diagrams'
export const HierarchicalTreeService: ValueProvider = { provide: 'DiagramsHierarchicalTree', useValue: HierarchicalTree};
export const MindMapService: ValueProvider = { provide: 'DiagramsMindMap', useValue: MindMap};
export const RadialTreeService: ValueProvider = { provide: 'DiagramsRadialTree', useValue: RadialTree};
export const ComplexHierarchicalTreeService: ValueProvider = { provide: 'DiagramsComplexHierarchicalTree', useValue: ComplexHierarchicalTree};
export const DataBindingService: ValueProvider = { provide: 'DiagramsDataBinding', useValue: DataBinding};
export const SnappingService: ValueProvider = { provide: 'DiagramsSnapping', useValue: Snapping};
export const PrintAndExportService: ValueProvider = { provide: 'DiagramsPrintAndExport', useValue: PrintAndExport};
export const BpmnDiagramsService: ValueProvider = { provide: 'DiagramsBpmnDiagrams', useValue: BpmnDiagrams};
export const SymmetricLayoutService: ValueProvider = { provide: 'DiagramsSymmetricLayout', useValue: SymmetricLayout};
export const ConnectorBridgingService: ValueProvider = { provide: 'DiagramsConnectorBridging', useValue: ConnectorBridging};
export const UndoRedoService: ValueProvider = { provide: 'DiagramsUndoRedo', useValue: UndoRedo};
export const LayoutAnimationService: ValueProvider = { provide: 'DiagramsLayoutAnimation', useValue: LayoutAnimation};
export const DiagramContextMenuService: ValueProvider = { provide: 'DiagramsDiagramContextMenu', useValue: DiagramContextMenu};
export const LineRoutingService: ValueProvider = { provide: 'DiagramsLineRouting', useValue: LineRouting};
export const ConnectorEditingService: ValueProvider = { provide: 'DiagramsConnectorEditing', useValue: ConnectorEditing};
/**
* NgModule definition for the Diagram component with providers.
*/
@NgModule({
imports: [CommonModule, DiagramModule],
exports: [
DiagramModule
],
providers:[
HierarchicalTreeService,
MindMapService,
RadialTreeService,
ComplexHierarchicalTreeService,
DataBindingService,
SnappingService,
PrintAndExportService,
BpmnDiagramsService,
SymmetricLayoutService,
ConnectorBridgingService,
UndoRedoService,
LayoutAnimationService,
DiagramContextMenuService,
LineRoutingService,
ConnectorEditingService
]
})
export class DiagramAllModule { } |
<template>
<div>
<p>{{value}}</p>
<p>
<Checkbox v-model="value" :datas="param">
<template slot="item" slot-scope="{item}">
<i :class="item.icon"></i>
<span>{{item.key}}:{{item.title}}</span>
</template>
</Checkbox>
</p>
</div>
</template>
<script>
export default {
data() {
return {
value: null,
param: [{ icon: 'h-icon-home', title: '选择1', key: 'a1', other: '其他值' }, { icon: 'h-icon-user', title: '选择2', key: 'a2' }, { icon: 'h-icon-task', title: '选择3', key: 'a3' }]
};
}
};
</script>
|
[Therapeutic use of hematopoietic growth factors. II. GM-CSF and G-CSF].
The second part of this review on haematopoietic growth factors is focused on the therapeutic use of GM-CSF and G-CSF. Such therapeutic applications have raised very great hopes for clinical haematology. However, it should not be forgotten that these haematopoietic growth factors, which are very costly, are powerful two-edged weapons capable of triggering a cascade of reactions, and have a field of activity that often goes beyond the single highly specific property which it is hoped they possess. The risks and costs of their use are currently being evaluated. Waited developments concerning these molecules focus on three axes: a best use of factors already commercialized, especially concerning adaptation of posologies and new indications, the development of hybrid molecules from already known haematopoietic growth factors, possessing the advantages of respective factors, but not their disadvantages, the discovery of new haematopoietic growth factors with potential therapeutic application. |
Tag Archives:Mariebergskogen
Karlstad is the surprisingly lively capital of western Sweden’s Värmland region. It’s home to one of the largest coffee brands in the Nordic countries, as well as a successful ice hockey club and Sweden’s largest rally event. Okay, okay: so
About Me
I'm a freelance travel writer and digital content marketer passionate about communication, meaningful travel and the bigger issues. Having written a variety of content for the European Union, peer-reviewed journals and online travel media, I currently craft digital content for clients in a range of industries in the Asia-Pacific region. |
Q:
Is mutableCopy call returns an array with a copy of the managed object context?
In a tutorial i'm learning CoreData from the preform something like this to fetch the collection of notes in a notes app:
- (void) viewWillAppear:(BOOL)animated
{
[super viewWillAppear:animated];
NSManagedObjectContext *managedObjectContext = [self managedObjectContext];
NSFetchRequest *fetchRequest = [[NSFetchRequest alloc] initWithEntityName:@"Note"];
self.notes = [[managedObjectContext executeFetchRequest:fetchRequest error:nil] mutableCopy];
[self.tableView reloadData];
}
So first of all, notes is an NSMutableArray, so tell me if I understand it right:
they creating an NSManagedObjectContext object to hold the context.
they create a request to get the "Note" entity from the database file.
they use the managedObjectContext to call executeFetchRequest with the requested request (which is fetchRequest). Now here is the part I dont completely understand (probably some of the previous ones as well, please correct me if I didn't):
The type of object i'm getting from this call [managedObjectContext executeFetchRequest:fetchRequest error:nil]; is an NSSet? and by calling mutableCopy i'm returning an array?
Thanks
A:
[managedObjectContext executeFetchRequest:fetchRequest error:nil]
returns an (immutable) NSArray, and mutableCopy creates a - well - mutable copy
of that array. It does not copy the managed objects in the array or the context.
It just allows you to modify self.notes, e.g. to add, delete or rearrange the objects
in the mutable array.
Remark: If you display objects from a Core Data fetch request in a table view
then you should have a look at NSFetchedResultsController. It might look a bit more
complicated at the beginning, but allows (for example) automatic updates of the
table view if objects are inserted, deleted or modified.
|
/**
* This file has no copyright assigned and is placed in the Public Domain.
* This file is part of the mingw-w64 runtime package.
* No warranty is given; refer to the file DISCLAIMER.PD within this package.
*/
import "wtypes.idl";
cpp_quote("#define TABLET_DISABLE_PRESSANDHOLD 0x00000001")
cpp_quote("#define TABLET_DISABLE_PENTAPFEEDBACK 0x00000008")
cpp_quote("#define TABLET_DISABLE_PENBARRELFEEDBACK 0x00000010")
cpp_quote("#define TABLET_DISABLE_TOUCHUIFORCEON 0x00000100")
cpp_quote("#define TABLET_DISABLE_TOUCHUIFORCEOFF 0x00000200")
cpp_quote("#define TABLET_DISABLE_TOUCHSWITCH 0x00008000")
cpp_quote("#define TABLET_DISABLE_FLICKS 0x00010000")
cpp_quote("#define TABLET_ENABLE_FLICKSONCONTEXT 0x00020000")
cpp_quote("#define TABLET_ENABLE_FLICKLEARNINGMODE 0x00040000")
cpp_quote("#define TABLET_DISABLE_SMOOTHSCROLLING 0x00080000")
cpp_quote("#define TABLET_DISABLE_FLICKFALLBACKKEYS 0x00100000")
cpp_quote("#define TABLET_ENABLE_MULTITOUCHDATA 0x01000000")
cpp_quote("#define WM_TABLET_QUERYSYSTEMGESTURESTATUS 0x02CC")
cpp_quote("#define IP_CURSOR_DOWN 0x1")
cpp_quote("#define IP_INVERTED 0x2")
cpp_quote("#define IP_MARGIN 0x4")
typedef DWORD CURSOR_ID;
typedef USHORT SYSTEM_EVENT;
typedef DWORD TABLET_CONTEXT_ID;
cpp_quote("#ifndef _XFORM_")
cpp_quote("#define _XFORM_")
typedef struct tagXFORM {
float eM11;
float eM12;
float eM21;
float eM22;
float eDx;
float eDy;
} XFORM;
cpp_quote("#endif")
|
Q:
In the context of C++, what is an "implementation"?
I am reading Accelerated C++ and there are lines written there about standard header
It is worth noting that although we refer to our own headers as header files, we refer to the
implementation-supplied headers as standard headers rather than standard header files. The
reason is that header files are genuine files in every C++ implementation, but system headers
need not be implemented as files.
My first question is that if we are running windows OS and in one hand we have codeblocks (GNU compiler) and in second we have turbo c++. So do we consider them as separate implementation?
My second question is that how actually these standard headers are implemented?
A:
The point the author is making is that the compiler, should it wish to do so, could implement #include <string> internally in the compiler, without there ever being any file called string in the system that compiles your code. In reality, I'm not aware of any compiler that DOES implement this, but it's certainly viable from what the C++ standards perspective.
Each compiler vendor, such as GNU and Free Software Foundation for gcc, the people at Illinois University behind clang, the people at Microsoft, Borland, IBM, Intel, etc that produce a compiler will produce "an implementation" of a compiler. If I write my own C++ compiler that will be an implementation. I happen to have my own compiler for the language Pascal (written in C++ and using LLVM as the backend) - which is an implementation of the language Pascal - and like all implementations, it follows the standard, but has some "implementation defined" features. All implementations will have some things that are "based on what the implementor choose to do", for several possible reasons:
The standard is not specific: size of int or Pascal's integer is not specified beyond "it must be at least this big ...", so as long as the minimum criteria is fulfilled, the implementor can do what he/she/they chooses.
Extensions - something that goes beyond the standard. Often the standard has restrictions or missing functionality that the implementor may decide to "improve" (this does make the implementation "non-standard", but if the extension doesn't alter the behaviour of standard compliant code, it's "safe" to add) [for example, Pascal doesn't have "names on files", so a Pascal program can't create a file by a particular name - most implementations do have SOME way to create a file by a particular name as an extension]
Standard specifies "implementation defined behaviour" - similar to non-specific, the standard can say that "this is up to the implementor to do as she/he/they wish".
|
Scanning tunnelling microscopic images of amino acids.
We present images of amino acids adsorbed on highly orientated pyrolytic graphite (HOPG) obtained with the scanning tunnelling microscope (STM) in air. Individual molecules can be observed although the majority of adsorbates appear to form clusters. In the case of leucine, methionine, and tryptophan, two molecules often associate together to form a dimer. Single or dimer glycine molecules were not seen, but a cluster of a number of them was observed. The various adsorbed states may be related to the different interactions between the amino acids and the graphite surface. The mechanism of image formation of the amino acids is probably related to charge transfer mechanisms. |
Lucasz has lived in the UK for over a decade and owns his own business in Cardiff.
But he’s concerned about what Brexit will mean for him and his family. |
You're using an old link.
If you're using a bookmark, please update it to the link below so that it continues working.
Thank you.
The new link is:
https://jahed.dev |
“I don’t want to be a nagging mother. I want everyone to do their part without me asking repeatedly.” I moaned. Teen daughter responded matter-of-factly with an irrefutable truth, “It’s just not going to happen, Mom. So accept it.”
She’s right, of course. A family in which the children operate as self-sufficient, self-motivated, responsible team members without parental involvement is about as realistic as a money tree. But my passion for nurturing self-esteem motivates me to find new ways to instill self-reliance. Because a child who can take care of herself feels capable. And a child who feels capable is more likely to take on new challenges and responsibilities. Each time she does, she generates self-esteem.
The trick is knowing how much a child can handle. Expecting too much discourages a child. Expecting too little stunts her personal growth. How to measure what’s just right? Follow the child.
Signs of overwhelm may be seen in these forms:
Self-defeating statements like, “I can’t do anything
right.”Exaggerated reactions: “This is stupid. Who cares about this anyway?”Backsliding: reverting to childish behaviors like
thumb-sucking or clinging to parent in social situations.
As a parent, I’ve been guilty of setting lofty expectations. When that happens, my children are quick to remind me that children are not miniature adults. On one particularly harried morning, I barked out a succession of orders to my eager-to-please seven year old. She
tried her best to keep up but eventually succumbed to tears of stress, blurting out between sobs, “Mom, I’m just a kid.”
It was my husband who suggested our current method of household responsibility. Envying my efficiency as I methodically crossed items off my to-do list, he asked if I would make him a list. Fearing the negative connotations of a ‘honey-do’ list, I was hesitant. Tween son chimed in, “Yeah, I’d like a list too. That way you don’t have to remind us all day.”
I began the ritual of leaving each child a list of expectations before leaving forwork. To my surprise, everything got done. Without my interference, they were free to go at their own pace. They had choices – what to do first, when to do it. Best of all, reports from work-at-home Dad indicated no complaints. There was no mother to complain to. No one to resist.
It takes some humility to admit that you, as a parent, could be a roadblock to a child. Sometimes we get in the way with our well-intentioned involvement believing that we hold the key to success. But the real prize goes to the child who works through a task on his own, problem-solving and overcoming frustrations along the way.
Parents need only set the expectation, offer hands-off guidance, and stay out of the way. When a child fails (and he will) natural consequences step in as highly effective teachers. For example, if a child forgets to make or bring her lunch to school and Mom does not deliver it, said child will be very hungry after school and will enjoy that lunch even more. And she probably won’t forget it the next day.
Giving responsibility to a child and allowing her to make mistakes is a gift. Don’t let your child’s complaining or resistance convince you otherwise. Mother knows best after all. |
Q:
Rework type definitions for analytics-node
There are type definitions for that library that exposes the class Analytics
So, sources are the next
class Analytics {}
module.exports = Analytics
Types definitions are good, shortly they are
declare namespace AnalyticsNode {
export class Analytics {}
}
export = AnalyticsNode.Analytics
But after those declarations the only way to use library is with
import Analytics = require('analytics-node')
How can I override types definitions locally to make them work in ES6 import way?
I tried to declare a module
declare module 'analytics-node' {
// export default
// export
// export =
}
But this doesn't work. (import * as Analytics from 'analytics-node' gets access to function, but no new Analytics raises an error in compiler)
I tried to follow guideline about module class definitions but without luck.
A:
It looks like the problem is in differences between CommonJS(node) and ES implementation of modules.
There is a flag in TS esModuleInterop that nullifies the difference between the two systems. With that flag, it's possible to have something like import module from 'module' instead of import * as module from 'module'
Here is a note from github issue by Andrew Fong.
absent esModuleInterop, the only way to use that syntax is for analytics-node to move to a default ES module export. Here's the thing though -- unless Node itself forces a migration to ES modules, the CommonJS single export remains perfectly valid. There technically isn't anything to fix. esModuleInterop isn't a hacky workaround. It's actually how, AFAICT, the TS devs want us to type these scenarios.
|
package org.graylog.storage.elasticsearch7;
import com.fasterxml.jackson.databind.ObjectMapper;
import com.google.common.collect.ImmutableMap;
import org.graylog.storage.elasticsearch7.cat.CatApi;
import org.graylog.storage.elasticsearch7.cluster.ClusterStateApi;
import org.graylog.storage.elasticsearch7.stats.StatsApi;
import org.graylog.storage.elasticsearch7.testing.ElasticsearchInstanceES7;
import org.graylog.testing.elasticsearch.ElasticsearchInstance;
import org.graylog2.indexer.cluster.NodeAdapter;
import org.graylog2.indexer.indices.IndicesAdapter;
import org.graylog2.indexer.indices.IndicesIT;
import org.graylog2.shared.bindings.providers.ObjectMapperProvider;
import org.junit.Before;
import org.junit.Rule;
import org.junit.Test;
import java.util.Map;
import static org.assertj.core.api.Assertions.assertThat;
public class IndicesES7IT extends IndicesIT {
@Rule
public final ElasticsearchInstanceES7 elasticsearch = ElasticsearchInstanceES7.create();
@Override
@Before
public void setUp() {
super.setUp();
}
@Override
protected ElasticsearchInstance elasticsearch() {
return elasticsearch;
}
@Override
protected IndicesAdapter indicesAdapter() {
final ObjectMapper objectMapper = new ObjectMapperProvider().get();
final ElasticsearchClient client = elasticsearch.elasticsearchClient();
return new IndicesAdapterES7(
client,
new StatsApi(objectMapper, client),
new CatApi(objectMapper, client),
new ClusterStateApi(objectMapper, client)
);
}
@Override
protected NodeAdapter createNodeAdapter() {
return new NodeAdapterES7(elasticsearch.elasticsearchClient());
}
@Override
protected Map<String, Object> createTemplateFor(String indexWildcard, Map<String, Object> mapping) {
return ImmutableMap.of(
"template", indexWildcard,
"mappings", mapping
);
}
// Prevent accidental use of AliasActions.Type.REMOVE_INDEX,
// as despite being an *Alias* Action, it actually deletes an index!
@Test
public void cyclingAliasLeavesOldIndexInPlace() {
final String deflector = "indices_it_deflector";
final String index1 = client().createRandomIndex("indices_it_");
final String index2 = client().createRandomIndex("indices_it_");
client().addAliasMapping(index1, deflector);
indices.cycleAlias(deflector, index2, index1);
assertThat(indices.exists(index1)).isTrue();
}
}
|
Q:
Should I say the morning blessing on head covering even if I don't cover my head?
Should unmarried women--and all those who do not cover their heads for whatever reason--still say the morning blessing "otayr yisro-ayl b'siforo" ("Who crowns Israel with splendor"), referring to head covering? Or would this be a bracha levatala?
A:
Based on my answer here it is a machloket rishonim if the blessing עוטר ישראל בתפארה is made by each individual on their own personal benefit, or if it is made on the general customs of the world. This same machloket should apply in your case as well.
|
FAQs
Frequently Asked Questions About our Products and Solutions
How many MD485 devices can be connected to a single data logger?
Typically, only one MD485 is connected to a data logger. Sometimes two are connected to create different network segments. Technically, however, one MD485 can be connected to each data logger serial port, and up to five MD485 devices can be connected to a single data logger CS I/O port. |
Q:
Transfer Variable from TableViewController to TableViewController
In the current project I'm working on I need to transfer variables from view to view.
I successfully transferred a variable from a tableviewcontroller to a UIviewcontroller like this.
if segue.identifier == "Done" {
let nav = segue.destinationViewController as! UINavigationController
let transfer = nav.topViewController as! quizViewController
transfer.questionArrays = questions2
}
But when I tried to transfer a variable from a tableviewcontroller to a tableview controller like this,
if segue.identifier == "answerSegue" {
let nav = segue.destinationViewController as! UINavigationController
let transfer = nav.topViewController as! answersTableViewController
transfer.index = rowIndex
}
I get an error saying
"Could not cast value of type list2.answersTableViewController"
So the question is, how can I transfer a variable from a UITableViewController to a UITableViewController?
Here is my story board.
Storyboard
A:
Firstly, you cast:
let transfer = nav.topViewController as! quizViewController
Then you cast:
let transfer = nav.topViewController as! answersTableViewController
This code is actually a bit strange and it's not possible to find out without posting more details.
Normally, you don't access the target controller over UINavigationController. You simply do something like:
let destinationController = segue.destinationViewController as! YourDestinationControllerClass
destinationController.variable = value
No need to involve UINavigationController at all.
Maybe this would work in your case ? :
if segue.identifier == "answerSegue" {
let transfer = segue.destinationViewController as! answersTableViewController
transfer.index = rowIndex }
|
This invention relates to a closure cap for a fuel receptacle. More specifically the closure cap includes a fuel level gauge and a venting arrangement for the receptacle and the invention resides in the provision of check valve means to prevent egress of any sloshed fuel from the receptacle through the venting arrangement.
Fuel receptacles having no baffles therein can give rise to the sloshing of fuel therein under certain conditions. Unless somehow prevented, the fuel can be sloshed out by the receptacle through the venting arrangement to possibly give rise to a fire hazard.
Often the venting arrangement for a fuel receptacle is provided in the closure cap. To prevent the egress of sloshed fuel is perhaps somewhat further complicated when the cap additionally includes a fuel level gauge. It is generally an object of this invention to provide a fuel receptacle closure cap having a venting arrangement and a fuel level gauge with check valve means to prevent egress of sloshed fuel from the receptacle. |
Q:
Subclass instance variables changing superclass instance variables in Ruby
In these two posts:
Instance Variables Inheritance
Can Ruby subclass instance variables _overwrite_ the superclass's (same name)?
People were writing about how in all OOP languages the superclass and derived classes don't have separate objects, and that when you create an instance of the derived class, it is also an instance of the superclass. There is one object and it's both classes at once.
Well, the problem is I don't get it? How can an object be both classes at once? And how can there instance variables be the same, if they use the same name of course?
I mean I get that subclasses get methods from there superclasses, but I don't get how they share there instance variables?
I've looked through at least four Ruby books and all that I've found was that instance variables don't get shared through the inheritance chain?
Could somebody please give a brief explanation of how and why the "instance variables" from the subclass are actually stored in the super class?
A:
The key thing to understand here is: instance variables are associated with the current object (or instance), while methods are associated with classes.
The reason for that is you don't want to have new methods created for every single object created if they are going to have the same body as all the other objects of that class.
On the other hand, instance variables have to be individual for each object, otherwise you will have a complete mash up when mutating values.
With that in mind, lets consider the following example:
class Foo
def foo
@var = :foo
end
end
class Bar < Foo
def bar
@var = :bar
end
end
Lets explore what happens when we create a new object:
baz = Bar.new
Currently, baz doesn't have any instance variables. It just has a pointer that says "Bar is my class".
baz.class # => Bar
The Foo or Baz classes don't have any such thing as @var associated with them. So currently, no one knows about @var.
When you call a method on baz, the method definition is searched in the Bar ancestors chain:
baz.class.ancestors # => [Bar, Foo, Object, Kernel, BasicObject]
You can note a few things here: Firstly, the things there appear in the order of inheritance. Secondly, Foo implicitly inherits from Object. Thirdly, modules can also be part of the chain (like Kernel).
baz.bar # => :bar
Will find the first thing in the chain that has a method #bar and call that. The value is assigned to the @var instance variable, which is associated with the object baz, not the classes Foo or Bar.
baz.foo # => :foo
Will now use the method definition from Foo. But again, @var is being changed in baz.
A few related things for future reading (as some of the above is not completely accurate for simplicity's sake):
singleton classes
class variables
including/prepending modules
Class.superclass # => Module
BasicObject#method_missing
|
According to LaTosha Myers-Mitchell, McNair and the victim were husband and wife, and she suffered from multiple gun shot wounds.
McLemore added that the shooting happened on North Chancellor Street in Palmers Crossing.
He said the victim was transported by ambulance to Forrest General Hospital and is in critical condition. |
package net.dean.jraw.test.unit
import com.winterbe.expekt.should
import net.dean.jraw.http.UserAgent
import org.jetbrains.spek.api.Spek
import org.jetbrains.spek.api.dsl.describe
import org.jetbrains.spek.api.dsl.it
class UserAgentTest: Spek({
describe("of") {
it("should format a User-Agent string") {
UserAgent(
platform = "lib",
appId = "net.dean.jraw",
version = "the best",
redditUsername = "thatJavaNerd"
).should.equal(UserAgent("lib:net.dean.jraw:the best (by /u/thatJavaNerd)"))
}
}
})
|
/* Generated by RuntimeBrowser
Image: /System/Library/PrivateFrameworks/NetworkStatistics.framework/NetworkStatistics
*/
@interface NWSSnapshotter : NSObject {
unsigned long long _kernelSourceRef;
NWSSnapshotSource * _snapshotSource;
}
@property unsigned long long kernelSourceRef;
@property (retain) NWSSnapshotSource *snapshotSource;
- (void).cxx_destruct;
- (unsigned long long)kernelSourceRef;
- (void)setKernelSourceRef:(unsigned long long)arg1;
- (void)setSnapshotSource:(id)arg1;
- (id)snapshot;
- (id)snapshotSource;
@end
|
Q:
How to block outgoing traffic (HTTP) from VMs?
I am playing with vmware ESXi v5 and installed a Win XP 32bit as one of the VMs inside.
I wish to block outgoing access (especially http) from the VM (maybe some form of firewall?), yet still allow:
Entry to the VM via RDC
Sharing of files or other features with other VMs (perhaps meaning within LAN) in the host kind of like via Workgroup. (this might need a seperate question)
Any ideas on how can I do the above? Still very new in VM-ing! But willing to learn! :)
A:
Assuming that your Windows XP VM is bridging to a physical interface on your ESXi box or part of a virtual switch connected to a physical interface on your ESXi box you have a few choices.
You could use the Windows XP firewall to control inbound and outbound network connections. This would be the quickest way to do this without changing any ESXi settings. You can read more here
You could build another VM or use a Virtual Applicance that would operate as a network firewall. You would then need to create two virtual switches. One that would be connected to your physical server interface and one of the interfaces on the firewall VM. You could note this as your "Outside Interface". Then one virtual switch that connects to the second interface on your virtual firewall VM and the interface of your Windows XP VM. You could note this as your "Inside Interface". The tricky part here is if you choose to NAT or route the traffic between your inside and outside. It may be easier to NAT the traffic and port forward the remote desktop connections, or you may feel comfortable advertising a new route to the subnet on the Inside interface. Some virtual firewall appliances may allow operation as a bridged firewall if so you could run the same subnet for the inside and outside interfaces, this may require extra work on the virtual switch to allow proxy ARP or permiscious traffic.
You could place a firewall device between the ESXi physical connection and what ever network you are attached to.
A:
I'd suggest one of the VMWare vShield products, perhaps 'App' or 'Edge' - take a look, there's lots of options.
|
This course offers an introduction to the functions of individual decision-makers—both consumers and producers—within the larger economic system. Emphasis is on the nature and functions of product markets, the theory of the firm under varying conditions of competition and monopoly, and the role of government in promoting efficiency in the economy.
Most people make the incorrect assumption that economics is ONLY the study of money. My primary goal in this course is to shatter this belief. During this course, we will be addressing the above questions as well as many more relating to:
-the environment
-love and marriage
-crime
-labor markets
-education
-politics
-sports
-business
My main goal is to show you the way economists think and how to use this analytical system to answer questions related not only to these and other important human issues, but to anything you end up doing with your life after this class. After all, as you will quickly find out, I believe that everything is economics!
From the lesson
Supply and Demand
Welcome to your second week in Microeconomics Principles! This module we will cover the hallmark framework of the field: the supply and demand model. I am sure that if you knew any economics words before enrolling in this course those two words were supply and demand. This module you will finally learn what all the fuss is about. |
Soft tissue recession around implants: is it still unavoidable?--Part I.
When treatment with dental implants is indicated, an accurate diagnosis must be made to evaluate the clinical parameters and determine the optimal time for immediate or delayed (ie, early or late) implant placement and loading following tooth extraction. It is also important to identify complications and their implications on the aesthetic outcome. This article explains the behavior of the hard and soft tissue around the implant, evaluates the timing of implant placement after extraction, and reviews various parameters that influence tissue marginal remodeling. |
// Module included in the following assemblies:
//
// * builds/creating-build-inputs.adoc
[id="builds-source-secret-combinations_{context}"]
= Source secret combinations
You can combine the different methods for creating source clone secrets for your
specific needs.
|
Q:
Return documents in query snapshot as json string firestore
I have a query made in node to firestore to get a collection of document. I want to write the collection as a json string to be parsed by an application. My code is as follows:
serverRef = db.collection('servers');
getDocs = serverRef.where('online', '==', true).get()
.then(querySnapshot => {
if (querySnapshot.empty) {
res.send("NO SERVERS AVAILABLE");
} else {
var docs = querySnapshot.docs;
console.log('Document data:', docs);
res.end(JSON.stringify({kind: 'freeforge#PublicServerSearchResponse',servers: docs}));
}
I get unnecessary data this way as all I get is document snapshots. How do I loop through the document snapshots and send them in one json string?
A:
The QuerySnapshot and Document classes are not simple JSON types. If you want to control what is written, you'll need to loop over querySnapshot (with map or forEach) and extract the JSON data for yourself.
One possible example:
serverRef = db.collection('servers');
getDocs = serverRef.where('online', '==', true).get()
.then(querySnapshot => {
if (querySnapshot.empty) {
res.send("NO SERVERS AVAILABLE");
} else {
var docs = querySnapshot.docs.map(doc => doc.data());
console.log('Document data:', docs);
res.end(JSON.stringify({kind: 'freeforge#PublicServerSearchResponse', servers: docs}));
}
});
|
Let’s be honest, there’s a lot of Pokemon fan art out there. But these creations are on an entirely different level. In the most epic pairing so far, artist, Kuisuku, matches Disney characters with Pokemon, showing us what it would look like if Disney characters were Pokemon Trainers. All of Kuisuku’s art was drawn in Flash and textures were added using Photoshop. If you’ve ever asked yourself, “What would Princess Jasmine’s Pokemon of choice be?” you now have your answer.
▼ Vanellope von Schweetz & Jigglypuff
▼ Simba & Shinx
▼ Princess Jasmine & Pidgey
▼ Belle & Ursaring
▼ Princess Tiana & Politoad
▼ Merida & Teddiursa
▼ Peter Pan & Scraggy
▼ The Cheshire Cat & Gengar
▼ Ariel & Magikarp
Source: Kotaku Japan
Images: Kuitsuku Deviantart |
GPI-anchor synthesis.
The glycosyl phosphatidylinositol (GPI) anchor of membrane proteins is widely distributed in eukaryotes and parasitic protozoa. The structure and biosynthetic pathway of its core have been elucidated and appear to be conserved in various species. Some of the genes involved in mammalian GPI-anchor biosynthesis have recently been isolated using GPI-anchor-deficient mutant cell lines and expression cloning methods. One of these genes proved to be responsible for a GPI-anchor deficiency known as paroxysmal nocturnal hemoglobinuria. Since the core of the GPI anchor is variously modified in different species and since there may be other differences between its biosynthetic pathway in parasites and their hosts, this pathway could be a target for chemotherapy. In this review, Taroh Kinoshita and Junji Takeda focus on the GPI-anchor biosynthetic pathway and the genes involved in it. |
This is a Visual Basic Script file which will remove Windows® Messenger from Windows® XP. It will also adjust your System Registry to prevent a long delay when opening Outlook Express when Windows Messenger is removed or disabled.
To use: Download the
xp_messenger_remove.vbs file and save it to your hard drive. Close Windows Messenger if its open, or active in your System Tray. Double-click the xp_messenger_remove.vbs file. You will be prompted that Messenger must be closed to continue. Click Yes. This script makes the same changes as the manual procedure, below.
If you prefer to remove Windows Messenger manually, click Start, Run and enter the following command: |
Camino! Camino
hacia adelante, con la cabeza mirando para abajo...
Hago Rap sin tener voz de cantante, Hip Hop por amor este no es mi trabajo
La pobreza en mi pueblo cada vez se expande es la humildad lo que a mi me hizo grande
Aprendí a estar solo sintiendo frío
Mi alma siempre
Casi me mande una locura, claro casi
En la calle donde conseguís problemas gratis
Mi cuerpo aguantaba no importaba el clima
Pedir como
Robar como
Les da mala vibra que alguien lleve un tatuaje
Mientras confiás en el ladrón que va de traje
Entonces me di cuenta la escasez de sus neuronas
La
No hacen una
Se que no hay cura para lo que se daña
También aprendí que las apariencias engañan
Tu no eres rico por tomarte un
Y yo no soy pobre por tomarme una
Drogas me llenaron de rencor tambien de ira
Instalé en mis circuitos un
En la calle aprendí a caminar y cuidarme
Comprender lo que leiste te da
Conocí la soledad el precio de la libertad
El egoísmo incentivo inseguridad
De haber tantos falsos suplicando realidad
La realidad me suplicó que yo siga haciendo RAP
Cómplice del que escupe verdad en los textos
Confío plenamente en cada uno de mis versos
Me baso en lo mío no en lo que diga el resto
Sigo respirando y es solo gracias a mi esfuerzo
Mis impulsos y el pulso me daban la razón
La burla de la gente me provocaba bajón
Solo quería rapear no llamar la atención
Rapear con la boca lo que decía mi
Sonrisa... con sabor a sufrimiento
Amargura noche oscura cae sobre mis notas
Cicatrices en el alma curadas en su momento
Sonrío sin motivos porque no me queda otra
Recuerdo cuándo era feliz y no lo sabía
A decir verdad disfruté de mi niñez
Pero a lo largo que va pasando esta vida
Hay cosas que no recuperás cuándo perdés
Por un instante creí creer en el amor
Aposté todo sin miedo a equivocarme
Me mando un atajo directo al dolor
Por eso, dudo que pueda enamorarme
Por una mujer a todos les tienes rencor
Muñecas de cartón pidiendo un mundo mejor
Te pones a pensar y a ninguna quieres querer
Recuerdo que mi vieja es mujer y ella si me dio
Al borde de la locura el RAP me dio la calma
Sudor en la frente con heridas en mis palmas
La verdadera riqueza no abita en tus bolsillos
Sino que fluye libremente en toda tu
La vista es egoísta solo vé superficies
El logro de tu trayecto depende de como inicies
Acumular dolor hizo que me desquicie
Mi sexto sentido me guía por donde pise
Solo soy una persona más en
Que rasca sus bolsillos en busca de
Gente ciega no ve la miseria que hay
Y videntes que ven la belleza que aún queda...
La belleza que aún queda...
|
add_library(empty2 ../empty.cpp $<TARGET_OBJECTS:objects>)
|
Sinxay and weaving our own transformation
When we were writing our introduction to Sinxay we wanted to include references to the transformation power of Sinxay. Sinxay, as a bodhisatta-hero, clearly follows the classic archetypal hero quest summarized by Joseph Campbell in The Hero with a Thousand Faces:
“A hero ventures forth from the world of common day into a region of supernatural wonder: fabulous forces are there encountered and a decisive victory is won:the hero comes back from this mysterious adventure with the power to bestow boons on his fellow man.”
Sinxay, as the son of Phanya Kousarat, honors his duty to his father, despite his having been banished from the palace when he was only several days old. He, unlike his six younger brothers, is willing to make the necessary sacrifices and heroic gestures in pursuit of fulfilling his father’s request. This is in stark contrast to his six younger brothers who covet the fame, glory, and power that would be Sinxay’s if he was successful in rescuing his aunt. The six brothers, although yearning to be acclaimed as heroes, cowered at the thought of actually doing anything heroic. They were unable to comprehend, as Joseph Campbell writes, that the hero can only be heroic when “we quit thinking primarily about ourselves and our own self-preservation,” because that’s when “we undergo a truly heroic transformation of consciousness.”
We agree with Joseph Campbell and believe Sinxay holds the power to be transformational, While doing our research, both in Laos and Isan, person after person told us what a dramatic effect Sinxay had made in transforming their lives and how excited they were that we were bringing to light such a little-known, but highly revered story.
As Jean Houston writes in The Wizard of Us, “Myth is the loom on which we may weave our own journey of transformation.” This is such a powerful analogy when one considers that weaving is the foundation of Lao culture. We really like the illustration above that shows a weaver taking a break from her loom and reading Sinxay from a palm leaf manuscript. This scene actually portrays how Dr. Thongkham, a literary scholar in Laos, learned the story of Sinxay, when as a young boy in his village he was lucky to live close to the weaver and listen to the weaver read it out loud.
For fun we’re including one of our many weaving videos on our YouTube channel below. Watching the Lao women weave is mesmerizing and provides a greater appreciation of their artistry and amazing skills. |
Chris Domico and Matt Dusenbury
Fire was our first true piece of technology. Around its warming glow, we would tell stories, share our thoughts, and bond with the people we love. Centuries later, our fires have been digitized, and thrown into everyone's pocket. They are infinitely more powerful. This is a podcast dedicated to exploring the intersection of technology and storytelling, from two writers connected by circuits, wires and a passion for writing.
Fire was our first true piece of technology. Around its warming glow, we would tell stories, share our thoughts, and bond with the people we love. Centuries later, our fires have been digitized, and thrown into everyone's pocket. They are infinitely more powerful. This is a podcast dedicated to exploring the intersection of technology and storytell...
Show more |
#if defined(macintoshSqueak)
#include "sqMacPrinting.h"
#else
#include "sqPrinting.h"
#endif
|
[Neurectomy in Menière's Disease (author's transl)].
The transtemporal vestibular neurectomy permits an ablation of the peripheral end organ with only a low risk to the cochlea. In a totally deaf ear the internal auditory meatus is reached by a translabyrinthine approach. Besides the vestibular nerve the chochlear nerve is cut to reduce tinnitus. The neurectomy is a destructive procedure. It should be performed in otherwise resistent cases of Menière's disease. |
Customer Reviews
"Being a reliable online shopping portal, Istiloshoppe has resourced itself with a team of market leading professionals, who are completely well-equipped with the knowledge of the needs of the customers."- Briefing Wire (Well-known Media Company)
"The item we ordered was out of stock and the seller contacted us immediately and offered a more expensive product at no extra charge. Great customer service and excellent product."- Timothy of Texas
"Istiloshoppe offers high quality and a wide variety of products. I was looking for a specific decal for my son's bedroom and can't find it anywhere in my local store and other big online retailers. Glad to bumped into this site and found what I was looking for. Highly recommended."- Gerard Rice of Pennsylvania |
Q:
VirtualBoxの共有フォルダの設定について
VirtualBoxにLinuxをインストールして、ホストとゲスト間で共有フォルダを作りたいです。
GuestAddtionsをインストール、VirtualBoxマネージャーから共有フォルダを追加して、自動マウントと永続化にチェックを入れましたが、ゲスト側から見れません。
ホストOSはWindows
ゲストOSはdebian
です。何か足りない手順がありますか?
よろしくお願いいたします。
A:
mount -t vboxsf 共有フォルダ名 マウント先ディレクトリ名
を試してみてください。
|
Discussion
Vegas: Great Cuban sandwich at Florida Cafe
I was in the mood for a Cuban sandwich the other day, so I headed over to the Florida Cafe , located in a Howard Johnson's on Las Vegas Blvd, between the Strip and downtown, a bit north of the Strat.
This is the real deal -- a Cuban restaurant run by Cubans, with lots of Cuban customers. The sandwich had roast pork, ham, and cheese, with pickles and mustard on a standard Cuban roll -- light crispy outside, poofy inside. I had them hold the pickles and add mayo and grilled onions. The sandwich was pressed thin of course. Instead of the usual accompanying fries, I opted for plantain chips (mariquitas) served with a tasty garlic sauce.
Probably the best Cuban I've had -- great flavor, quality ingredients. Nice service, pleasant coffee-shop atmosphere. The waiter made me a fresh-squeezed limeade even though it wasn't on the menu.
Florida Cafe is one of the few places we must eat at when in Vegas. The ropa vieja is always spot on. The pork roast can be a little dry but the flavor is good. Love the rice & beans, I could eat that everyday. Oh, & the tres leches cake, my favorite cake ever!I haven't tried Rincon Criollo, but am thinking I will next time I'm in Vegas. |
Have completed the final active treatment visit for an originating study eligible to
enroll participants directly into study BREEZE-AD3 OR
Meet criteria for NCT03334396 or NCT03334422.
Exclusion Criteria:
Had investigational product permanently discontinued at any time during a previous
baricitinib study.
Had temporary investigational product interruption continue at the final study visit
of a previous baricitinib study and, in the opinion of the investigator, this poses an
unacceptable risk for the participant's participation in the study. |
Q:
Should underscore(_) prefix be added to method input parameters in Dart?
Both compiles but I wonder which version is correct?
int add(int _a, int _b) {
return _a + _b;
}
or
int add(int a, int b) {
return a + b;
}
A:
According to Effective Dart
There is no concept of “private” for local variables, parameters, or library prefixes. When one of those has a name that starts with an underscore, it sends a confusing signal to the reader. To avoid that, don’t use leading underscores in those names.
So according to the guideline below code is more correct,
int add(int a, int b) {
return a + b;
}
|
Open Source Entrepreneur Meetup: Let's Talk About Open Source Business
I'll be presenting my talk on open source product development in a multi-platform world, looking at product development from a supply chain perspective.
In olden times, when we used IRC and liked it, there were several steps along the way from creating an open source project to releasing a product. Some of these were artifacts of the (lack of) tooling of the time, such as the need to assemble pieces into a whole before releasing as a product. That "first cut" of distribution became a community project in itself. Now that we have better, automated tooling for development, you may be fooled into believing that this "first cut" step is no longer needed. Au Contraire! John Mark will demonstrate why this is still necessary with examples from Fedora, CloudFoundry and Moby.
This will help you determine your community building strategy as it relates to product management and engineering. As I'll demonstrate, these things are all inter-related. |
DNA cleavage function of seryl-histidine dipeptide and its application.
The double-stranded DNA or circular plasmid DNA can be cleaved by the Ser-His dipeptide by hydrolysis of the DNA-phospho-diester bond. The proper sequential order of the amino acids serine and histidine is apparently crucial in its unique cleavage activity as compared to the other di- or tri-peptides containing one of these amino acids. An inverted sequence of this dipeptide to a His-Ser linkage renders the peptide ineffective in the cleavage of DNA. In addition to the DNA cleavage function, Ser-His is also capable of cleaving other molecules, e.g., proteins, esters and RNAs. The cooperative actions of the hydroxyl group and the basic groups in the serine and histidine or related amino acids can be found in contemporary enzymes, such as DNase, serine proteases, lipases, esterases, chymotrypsin, trypsin, and elastase, etc. The Ser-His and related oligopeptides might have played important roles in the evolution of enzyme functions. |
Implementing Process Analytical Technology for the Production of Recombinant Proteins in Escherichia coli Using an Advanced Controller Scheme.
The performance of a bioreactor in meeting process goals is affected by the microorganism used, medium composition, and operating conditions. A typical bioreactor uses a supervisory control and data acquisition (SCADA) system for control, and a combination of software and hardware tools for real-time data analysis. However, when the process is disrupted by utility or instrumentation failure, typical process controllers may be unable to reinstate normal operating conditions before the cells in the reactor shift to unfavorable metabolic regimes. The objective of this study is to examine how the response of a controller affects process recovery when disruptive incidences occur under a process analytical technology (PAT) framework. The process used for this investigation is the production of lethal toxin-neutralizing factor (LTNF) by Escherichia coli (E. coli), which is controlled by a decoupled input-output-linearizing controller (DIOLC). The performance of the DIOLC is compared to a proportional integral derivative (PID) controller subjected to the same conditions. The disruptions are introduced manually and the effect of controller action on process recovery and LTNF synthesis is measured in terms of peak purity and concentration. It is observed that DIOLC performs better after reinstating operating conditions and results in a meaningful improvement in performance. |
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