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Stable expression of polymorphous forms of human cytochrome p450 2d6 |
The present invention relates to a test system containing cell lines expressing human cytochrome P450 2D6 as well as to the use of said test system for the study of pharmacological and toxicological aspects of the hCYP2D6 polymorphism. The present invention further relates to methods for the detection of novel polymorp... |
1. Test system consisting of cells expressing a cytochrome P450 2D6 (hCYP2D6) allele in a heterologous manner wherein at least three P450 2D6 alleles are expressed in said test system. 2. Test system according to claim 1 wherein said at least three P450 2D6 alleles correspond to the most frequent allele types in a popu... |
Connecting device for fluids |
A connection means for two base bodies (3a and 3b) of a subassembly conducting a fluid. On each base body (3a and 3b) holding means are provided, which respectively have at least one holding pin (16) projecting toward the respectively other base body (3a and 3b), such holding pin fitting between two coupling bodies (17... |
1. A connection means for two base bodies of a fluid conducting subassembly and more particularly a modularly designed device for treating compressed air, comprising holding means provided on the mutually facing connection faces (9a and 9b) of the base bodies (3a and 3b) to be connected, and furthermore a coupling unit... |
Process for preparing optically active 2-[6-(hydroxy-methyl)-1,3-dioxan-4-yl] acetic acid derivatives |
The present invention is to provide a production technology by which an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative, which are of value as pharmaceutical intermediates, can be produced from inexpensive and readily available starting materials without using any extraordinary equipment su... |
1. A production process of a following compound (I); in the formula, R1 represents a hydrogen, an alkyl group of 1 to 12 carbon atoms, an aryl group of 6 to 12 carbon atoms, or an aralkyl group of 7 to 12 carbon atoms; R2 and R3 each independently represents a hydrogen, an alkyl group of 1 to 12 carbon atoms, an aryl g... |
<SOH> BACKGROUND ART <EOH>The hitherto-known technology for producing 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivatives includes the following processes. (1) A process starting with 3-hydroxy-γ-butyrolactone to synthesize a 3,5,6-trihydroxyhexanoic ester derivative via a 3,5-dihydroxyhexanoic ester derivati... |
<SOH> SUMMARY OF THE INVENTION <EOH>In the above state of the art, the object of the present invention is to provide a production technology by which an optically active 2-[6-(hydroxymethyl)-1,3-dioxan-4-yl]acetic acid derivative represented by the following formula (I), which are of value as pharmaceutical intermedia... |
System and method for creating a searchable word index of a scanned document including multiple interpretations of a word at a given document location |
Multiple recognition engines (110) provide different interpretations (116) of a word at a given location within a scanned document (108). A word node corresponding to each unique interpretation is stored within a word index (102), with each word node being linked to word nodes of previously and subsequently recognized ... |
1. A method in a computer system for creating a searchable word index of a scanned document, the method comprising: generating a first interpretation of a word at a given location within the scanned document using a first recognition engine; generating a second interpretation of the word using a second recognition engi... |
<SOH> TECHNICAL BACKGROUND <EOH>In the field of optical character recognition (OCR), analog documents (e.g., paper, microfilm, etc.) are digitally scanned, segmented, and converted into text that may be read, searched, and edited by means of a computer. In order to provide for rapid searching, each recognized word is ... |
<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>Non-exhaustive embodiments of the invention are described with reference to the figures, in which: FIG. 1 is a block diagram of a conventional system for creating a searchable word index of a scanned document; FIG. 2 is a block diagram of a system for creating a searchable ... |
Terry tile board |
The board provides protection against damage on a slate shingle and tile roof. The upper side of board with plywood serves as the solid foundation for standing on as tool is laid upon the roof. The opposite or under side has plywood and foam rubber. This side is placed directly onto the roof. An added feature is the bo... |
1. A tool for protection of roofs, the tool consisting of one piece of plywood, having wood slats and a non-slip surface on one side with other side bearing an adhesive and foam rubber. |
Acid-sensitive compounds, preparation and use thereof |
Novel acid-sensitive compounds comprising at least one hydrophilic substituent and a cyclic ortho-ester which is acid-sensitive, and their salts. These compounds are useful for forming conjugates (liposomes, complexes, nanoparticles and the like) with biologically active substances and releasing them into cellular tiss... |
1. Acid-sensitive compounds characterized in that they comprise a cyclic ortho-ester and at least one hydrophilic substituent chosen from polyalkylene glycols, mono- or polysaccharides, hydrophilic therapeutic molecules, or alternatively radicals of the polyamine type, as well as their salts. 2. Acid-sensitive compound... |
Jaw orthopedic device |
The invention comprises a jaw orthopedic device for the movement and/or correction of teeth in the tooth arch with a synthetic resin element and/or at least one mature element or tooth contacting or tooth movement, whereby the synthetic resin element is comprised of a hard synthetic resin material and the synthetic res... |
1. A jaw orthopedic device for the movement and/or correction of teeth in the tooth arch having a synthetic resin element and/or at least one wire element for tooth contacting or tooth movement, whereby the synthetic resin element is comprised of a hard synthetic resin material, characterized in that the synthetic resi... |
Device for the dosing of a reducing agent |
An apparatus for metering a urea or a urea-water solution for delivery to a catalytic converter assembly for removing nitrogen oxides from the exhaust gases of a Diesel engine, includes a housing block supporting function components communicating via a line, formed by recesses in the housing block, for transporting the... |
1-14. (Canceled) 15. An apparatus for metering a reducing agent, in particular urea or a urea-water solution, comprising a housing block, means (4, 7, 11), secured to the housing block for delivering the reducing agent to a catalytic converter assembly (30) for removing nitrogen oxides from the exhaust gases of a Diese... |
Starting device |
A starter device for internal combustion engines is proposed that comprises a drive mechanism (16) and a gearing (22) having a variable gear ratio, which said gearing is situated after the drive mechanism (16). The starter device (10) is characterized by the fact that the gear ratio of the gearing (22) is infinitely va... |
1. A starter device for internal combustion engines comprising a drive mechanism (16) and a gearing (22) having a variable gear ratio, which said gearing is situated after the drive (16), wherein the gear ratio is infinitely variable. 2. The starter device according to claim 1, wherein the gearing (22) is self-regulati... |
<SOH> BACKGROUND OF THE INVENTION <EOH>The invention concerns a starter device for internal combustion engines according to the general class in the independent claim. A starter device is made known in DE 199 27 905 A1, which said starter device comprises a gearing between a drive element and a pinion, which said gear... |
<SOH> SUMMARY OF THE DRAWINGS <EOH>Exemplary embodiments of a starter device according to the invention are shown in the drawings. FIG. 1 shows a schematic view of a starter device according to the invention. FIG. 2 shows a spacial sectional detail view of the torque-controlled gearing, FIG. 3 shows a spacial sectiona... |
Force -transmision unit comprising speed -dependent hydraulic clutch and centrifugal force compensation |
A power transmission unit with a hydraulic coupling dependent on a rotational-speed difference, in which, when a rotational-speed difference occurs between the input member (1) and the output member (6), a hydrostatic displacement machine (20) produces in a pressure space (34) a pressure that acts on a piston (27) acti... |
1. A power transmission unit with an input member and an output member and a hydraulic coupling dependent on a rotational-speed difference, in which, when a rotational-speed difference occurs between the input member (1; 6) and the output member (6; 1), a hydrostatic displacement machine (20) produces in a pressure spa... |
Encasing arrangement for a semicoductor component |
A semiconductor component package configuration includes a semiconductor chip mounted to a printed circuit board, and a substrate arranged between the semiconductor chip and the printed circuit board. The substrate is for routing the wiring terminals of the semiconductor chip to the printed circuit board. The substrate... |
1-13. Cancel 14. A semiconductor component package configuration, comprising: a semiconductor chip having wiring terminals; a printed circuit board having said semiconductor component mounted thereon; a substrate configured between said semiconductor chip and said printed circuit board, said substrate for routing said ... |
Termination device e.g. for a multiconnector |
A termination device e.g. for a multiconnector comprises a cover (2) which is rotatably hinged to a housing (1), and which has a hole for receiving a cable containing a plurality of wires (5a-e). When the individual wires are arranged in respective slits in the cover, the housing and the cover may be rorated mutually t... |
1. A termination device, e.g. for a multiconnector and comprising a plurality of protruding terminals and a cover which, upon closing of the device, is adapted to guide and force a wire associated with each terminal down into the terminal to provide an electrical connection between the wire and the terminal, and wherei... |
Compounds and methods for the treatment of pain |
2-substituted 7-chloro-4-hydroxy-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione compounds, pharmaceutical compositions and methods for the treatment of pain are disclosed. |
1. A compound selected from: 7-chloro-4-hydroxy-2-(4-[1,3,4]oxadiazol-2-yl-benzyl)-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione; 7-chloro-4-hydroxy-2-[3-(1H-tetrazol-5-yl)-benzyl]-1,2,5,10-tetrahydropyridazino[4,5-b]quinoline-1,10-dione; 4-[(7-chloro-4-hydroxy-1,10-dioxo-2,5-dihydropyridazino[4,5-b]quinolin... |
<SOH> FIELD OF THE INVENTION <EOH>This invention relates to the treatment or prevention of pain or nociception. |
<SOH> SUMMARY OF THE INVENTION <EOH>It has now been discovered that certain compounds which exhibit the property of binding to the NMDA receptor glycine site have utility for the amelioration of pain and particularly for the amelioration of neuropathic pain. Therefore, in a first aspect the present invention provides ... |
Repressible sterility of animals |
A construct which allows animals to be bred in captivity but renders them infertile in the wild by allowing reversible control over fertility and reproduction. The construct comprises: a first promoter that is activated in a defined spatial (tissue specific) or temporal manner linked to DNA encoding a transactivating p... |
1. A method of controlling fertility in an animal comprising the steps of: 1) stably transforming an animal cell or single celled embryo with a construct comprising: a) a first nucleic acid molecule, which is activated in a defined spatio-temporal pattern, and which is operably linked to b) a second nucleic acid molecu... |
<SOH> BACKGROUND OF THE INVENTION <EOH>Feral animals are one of the world's major environmental problems. Goats, cats, rabbits and carp are only the more prominent of hundreds of species traded internationally for recreation or agriculture that have escaped into the wild and formed destructive populations. Terrestrial... |
<SOH> SUMMARY OF THE INVENTION <EOH>In its most general aspect, the invention disclosed herein provides a nucleic acid construct which may be inserted into the genome of any target organism. The construct can use any promoter/gene combinations, provided that they satisfy the criteria of being activated only during emb... |
Image pickup device, and image pickup device assembling method |
The invention integrally arranges a lens, an optical filter, a semiconductor imaging device, on-chip components, and a printed circuit board on a three-dimensional circuit board and contrives the lens attachment structure, bonding method, color of an adhesive, masking of the lens, etc. in order to implement a structure... |
1. Imaging apparatus comprising: a semiconductor imaging device on a surface of the imaging apparatus; and a three-dimensional circuit board above said semiconductor imaging device. 2. Imaging apparatus comprising: a three-dimensional circuit board having a leg and a cylindrical barrel provided on the leg; a semiconduc... |
<SOH> BACKGROUND OF THE INVENTION <EOH>Conventionally, concerning imaging apparatus of this type, as the semiconductor imaging device to convert a picture shot by lenses to an electric signal has become smaller and high-performance, the camera has become compact and has been used in various applications thus enhancing... |
<SOH> BRIEF DESCRIPTION OF THE DRAWINGS <EOH>FIG. 1 is a perspective view of imaging apparatus in Embodiment 1 of the invention. FIG. 2 is a sectional view of imaging apparatus in Embodiment 1 of the invention. FIG. 3 is a sectional view of imaging apparatus in Embodiment 2 of the invention. FIG. 4 is a perspective vi... |
Ultrasonic diagnosing apparatus |
An ultrasonic diagnostic apparatus transmits an ultrasonic beam into an object to be examined using a multi-ring arrangement formed with transducer elements arrayed two-dimensionally in concentric rings and receives an echo so as to create a tomogram or a three-dimensional image of the object. To correct for focusing e... |
1. An ultrasonic diagnostic apparatus comprising a probe having two-dimensional array of transducer elements for transmitting and receiving ultrasonic waves to an object to be examined, in which a circular pattern of transducer elements is formed for transmitting and receiving an ultrasound signal by bundling the trans... |
<SOH> BACKGROUND OF THE INVENTION <EOH>An apparatus having a plural number of transducer composed of a two-dimensional transducer array in which sector scanning is performed using an ultrasonic beam (in an arbitrary direction) generated by a transmitting/receiving circular pattern of transducers formed in the two-dime... |
<SOH> SUMMARY OF THE INVENTION <EOH>To achieve the foregoing object, an ultrasonic diagnostic apparatus is provided in accordance with the present invention, in which there is a probe comprising a plural number of transducer elements formed as a two-dimensional array for transmitting/receiving an ultrasound to an obje... |
TORSION SENSOR |
The invention relates to a device for providing an axial force subject to a torque, which device has a first shaft with a friction surface comprising at least a radial directional component; a second shaft which is placed parallel with at least an axial directional component to the first shaft; a friction member arrang... |
1. Mechanical transmission, comprising: a frame; a first and second friction device, which device comprises: a first shaft with a friction surface comprising at least a radial directional component; a second shaft which is placed parallel with at least an axial directional component to the first shaft; a friction membe... |
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