title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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References | PMC9831378 | |||
Background: | ’ | SECONDARY | Fathers are important in establishing healthy behaviors in their children, but are rarely engaged in lifestyle programs. Focusing on physical activity (PA) of both fathers and their children by engaging them together in PA (i.e. “co-PA”) is therefore a promising novel strategy for interventions. The study aim was to in... | PMC9930712 |
Methods: | SECONDARY | This study is a non-randomized controlled trial (nRCT), including 98 fathers and one of their 6 to 8 years old children (intervention = 35, control = 63). The intervention was implemented over a 14-week period, and consisted of six (inter)active father-child sessions and an online component. Due to COVID-19, only 2/6 s... | PMC9930712 | |
Results: | ’ | Significant intervention effects were found for co-PA (+ 24 min./day in the intervention compared to the control group, p = 0.002), and MPA of the father (+ 17 min./day, p = 0.035). For children, a significant increase in LPA (+ 35 min./day, p < 0.001) was found. However, an inverse intervention effect was found for th... | PMC9930712 | |
Conclusion: | The Run Daddy Run intervention was able to improve co-PA, MPA of fathers and LPA of children, and decreasing their SB. Inverse intervention effects were however found for MPA and VPA of children. These results are unique given their magnitude and clinical relevance. Targeting fathers together with their children might ... | PMC9930712 | ||
Trial registration number: | This study is registered as a clinical trial (clinicaltrials.gov, ID number: NCT04590755, date: 19/10/2020). | PMC9930712 | ||
Keywords: | PMC9930712 | |||
Background | ’ | Physical inactivity is a global pandemic and a leading cause of physical and mental health issues [Lifestyle interventions targeting children’s health behaviours, including PA, have often included parents as an important focus of change, as parents play a critical role in the health behaviours of their children [It is ... | PMC9930712 | |
Methods | PMC9930712 | |||
Study design | The design of the Run Daddy Run study was a non-randomized controlled trial (nRCT), with a two-group pretest-posttest control group. In this design, participants were recruited in sequence (see Fig. Measurements were performed immediately before the intervention (baseline) and immediately after the 14-week intervention... | PMC9930712 | ||
The Run Daddy Run intervention | PMC9930712 | |||
Development of the intervention | The Behaviour Change Wheel was used as a theoretical framework to systematically develop the intervention [ | PMC9930712 | ||
Content of the intervention | FMS | FMS | The aim of the intervention was to improve father-child co-PA, and consequently the objectively measured PA levels of both. Secondary aims of the intervention were to target (co-) sedentary behaviour (SB), body mass index (BMI), family health climate regarding PA and the quality of father-child relationship. The Behavi... | PMC9930712 |
The intervention and restrictions during COVID-19 | MAY | During the baseline measurements (November-January 2019–2020), no COVID-19 restrictions were applicable. During the post-test measurements (in June 2020), “mild” COVID-19 restrictions were applicable, meaning that (1) catering industry (e.g. restaurants, bars, cafés) and (non-essential) shops were open, (2) school were... | PMC9930712 | |
Sample size | The required sample size to evaluate the effect of the intervention was calculated, using the software GPower 3.0.10 [ | PMC9930712 | ||
Participants and recruitment | RECRUITMENT | The Run Daddy Run intervention targeted fathers and (one of) their children of the first three years of primary school (i.e. 6–8 years old). For more information on recruitment, see [Father-child dyads were recruited through convenience and snowball sampling, in November 2019-January 2020 (see also [ | PMC9930712 | |
Co-physical activity | Co-PA includes all types of PA that involves “active play”, and is jointly performed by the father and the child (e.g. playing soccer together, rough-and-tumble play, cycling). Co-PA was measured using a 7-day recall diary, investigating all physical activities fathers and children performed together in the last seven ... | PMC9930712 | ||
Physical activity and sedentary Behaviour | PMC9930712 | |||
Data collection | Device-based | Device-based measures of PA and SB data were collected using wrist-worn accelerometers (Axivity AX3, 3-axial) (continuous wave-form data, sampling frequency 100-Hz). Compared to hip-worn accelerometers, wrist-worn accelerometers have better wear time adherence and acceptability [ | PMC9930712 | |
Data processing | Minus | Based on the accelerometer data, participants’ total volume of PA (mean Euclidean Norm Minus One (ENMO, in m | PMC9930712 | |
Secondary outcomes: body mass index, PA family health climate and quality of the father-child relationship | Fathers’ Body Mass Index (BMI, in kg/m²) was calculated based on self-reported height and weight through the online questionnaire. BMI z-scores (i.e. a sex- and age adjusted measure of BMI) of children were also calculated based on their weight and height, which were proxy-reported by the father in the questionnaire. T... | PMC9930712 | ||
Results | PMC9930712 | |||
Descriptive statistics | In total, data of 98 father-child dyads were analyzed at baseline (mean age fathers/male caregivers: 43.79 ± 5.92 years, mean age primary school aged children: 8.19 ± 0.99 years; 50.90% boys). The flow diagram of participants throughout the study can be found in Fig. | PMC9930712 | ||
Primary outcomes | PMC9930712 | |||
Co-physical activity | Results for the self-reported co-PA outcomes are shown in Table | PMC9930712 | ||
Physical activity | For PA of the father, relative to the control group, the intervention group significantly improved from pre- to post-test for total volume of PA (+ 6.1 m | PMC9930712 | ||
Secondary outcomes: sedentary behaviour, body mass index, PA family health climate and quality of the father-child relationship | SECONDARY | Results for the secondary outcomes are shown in Table | PMC9930712 | |
Discussion | ’ | SECONDARY | This study evaluated the effects of a theory-based, co-created intervention aiming to improve co-physical activity (i.e. the father and the child being active together), which was used as a strategy to increase PA in both children and fathers. The ‘Run Daddy Run’ intervention led to an increase in self-reported father-... | PMC9930712 |
Acknowledgements | Not applicable. | PMC9930712 | ||
Author contributions | JL and GC designed the project. RB conducted the accelerometer data processing. JL conducted the data analysis, under the supervision of RB. PJM provided additional input for the study design. JL wrote the original draft. GC, PJM, RB and SC edited the manuscript and provided feedback. All authors read and approved the ... | PMC9930712 | ||
Funding | The research of authors Julie Latomme and Ruben Brondeel is funded by Research Foundation Flanders. The funding body is not involved in the study design, collection, management, analysis and interpretation of data or in writing of the report. | PMC9930712 | ||
Data Availability | The datasets used and analyzed during the current study, and the full trial protocol, are available from the corresponding author on reasonable request. | PMC9930712 | ||
Ethics approval and consent to participate | This study was approved by the Committee of Medical Ethics of the Ghent University Hospital (Belgian registration number: B670201941599) and registered as a clinical trial on 19/10/2020 (Clinicaltrials.gov NCT04590755). Participants of this study received an information letter in which they were informed on the study, ... | PMC9930712 | ||
Consent for publication | Not applicable. | PMC9930712 | ||
Competing interests | The authors declare that they have no competing interests. | PMC9930712 | ||
Abbreviations | Minus | Physical activity.Light physical activity.Moderate physical activity.Vigorous physical activity.Moderate-to-vigorous physical activity.Sedentary behaviour.milli-gravitational unit.Euclidean Norm Minus One.Co-physical activity.Fundamental Movement Skills. | PMC9930712 | |
References | PMC9930712 | |||
Introduction | cancer | CANCER | Open access funding provided by SCELC, Statewide California Electronic Library ConsortiumSince the beginning of the COVID-19 pandemic, the use of remote telemonitoring and telehealth platforms has been of steadily increasing interest, and implementation continues to rise [One population that has been identified as pote... | PMC10694107 |
Materials and methods | PMC10694107 | |||
Patients | gastrointestinal oncologic surgery | Patients undergoing gastrointestinal oncologic surgery (all colorectal surgery, pancreatectomy, hepatectomy and gastrectomy) at a single institution over 18 years of age who could read and write in English were eligible for inclusion. All eligible patients were screened. Only those patients who had completed all partic... | PMC10694107 | |
Randomization and procedures | A study algorithm detailing randomization, subsequent allocation, and follow-up is shown in the CONSORT diagram in Fig. CONSORT diagramSatisfaction tool | PMC10694107 | ||
Outcomes | The primary outcome was feasibility as defined by the percent of patients completing electronic surveys at 70% of all time points. Acceptability was assessed by a patient satisfaction tool assessing ease of use, time burden of participation, and technological access after completion of the 30-day tracking period (Fig. | PMC10694107 | ||
Statistical analysis | Univariate analysis was performed using SPSS version 28.0 (Armonk, New York). Patient characteristics including demographics and surgical treatment were compared between groups using Student’s t-test for continuous variables, the Pearson Chi-square test for categorical variables, and the Mann–Whitney U test for ordinal... | PMC10694107 | ||
Results | One hundred and six patients were screened, of which 83 (78.3%) consented to participate and 65 (78.3%) completed participation by August 31, 2022 (Fig. Patient demographicsPerioperative characteristicsLaparoscopic orMIS/robotic assisted Overall, 88% (57 patients) completed 70% of the time points. Patients in the inter... | PMC10694107 | ||
Discussion | PGHD, gastrointestinal oncologic operations | COMPLICATIONS | This study is one of the first to incorporate PGHD in the form of vital signs, mobility, and ePROs, coupled with nursing intervention triggered by set thresholds [However, there are many questions to be answered regarding the applicability and utility of such an approach in the perioperative care of such patients. The ... | PMC10694107 |
Funding | Open access funding provided by SCELC, Statewide California Electronic Library Consortium. This study was funded by NIH grant, sponsor ID NR019866-01. | PMC10694107 | ||
Declarations | PMC10694107 | |||
Conflict of interest | The authors declare they have no conflict of interest to disclose. | PMC10694107 | ||
Ethical approval | Informed consent was obtained from all individual patients included in the study. This study was approved by the institutional review board and was performed in accordance with the ethical standards as laid down by the Declaration of Helsinki. | PMC10694107 | ||
References | PMC10694107 | |||
Abstract | PMC10013951 | |||
Introduction | knee arthroplasty, TKA, pain | We aimed to evaluate the efficacy of electroacupuncture in relieving acute pain after total knee arthroplasty (TKA) and related mechanism. | PMC10013951 | |
Methods | electroacupuncture, postoperative acute pain, sham‐acupuncture | In this randomized, single‐blind, and sham‐acupuncture controlled study. Forty patients with postoperative acute pain were recruited and randomly divided electroacupuncture group ( | PMC10013951 | |
Results | calcarine fissure, acute pain, TKA | CORTEX | Compared with the HCs, patients with acute pain following TKA had significantly decreased ALFF value in right middle frontal gyrus, right supplementary motor area, bilateral precuneus, right calcarine fissure and surrounding cortex, and left triangular part of inferior frontal gyrus (false discovery rate corrected | PMC10013951 |
Conclusions | acute pain, pain | The functional activities of related brain regions decreased in patients with acute pain after TKA. The enhancement of the functional activity of precuneus may be the neurobiological mechanism of electroacupuncture in treating pain following TKA.
Bingxin Kang, Chi Zhao, and Jie Ma contributed equally. | PMC10013951 | |
INTRODUCTION | postoperative pain, human diseases, acute postoperative pain, acute pain, Tu, knee osteoarthritis, pain, knee arthroplasty, KOA, TKA, migraine | DISORDERS, CHRONIC PAIN, MIGRAINE, KNEE OSTEOARTHRITIS | Total knee arthroplasty (TKA) can effectively treat end‐stage knee osteoarthritis (KOA) by reducing pain and helping patients to resume daily life activities. Acute postoperative pain after TKA prolongs rehabilitation duration, weakens the therapeutic effect, and thereby decreases the patient's quality of life. Intense... | PMC10013951 |
MATERIALS AND METHODS | PMC10013951 | |||
Standard protocol approvals, registration, and consents | The study took place at Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine from November 1, 2020 to October 31, 2021. The study protocol was preregistered with ClinicalTrials.gov (No.ChiCRT2000033778, June 14, 2020, | PMC10013951 | ||
Study participants | loss of consciousness, neurological and psychiatric disorders, pain, KOA, claustrophobia, head trauma, NRS | HYPERPYREXIA, ORGANIC DISEASE, DISEASES | Enrolled were KOA patients having undergone primary unilateral TKA. The inclusion criteria included (1) aged 60–80 years; (2) right‐handed; (3) a pain intensity score of 5 or higher on a 0–10 Numerical Rating Scale (NRS); (4) a score > 24 on the Minimum Mental State Examination. The excluded criteria included (1) a his... | PMC10013951 |
Experimental design and sample size | postoperative pain, NRS, sham‐acupuncture, pain | A participant‐blinded, randomized and sham‐acupuncture (SA) controlled clinical trial was applied. Previous studies have shown that 15 participants should be included in each group to ensure stable statistical effect for brain fMRI analysis (Qiu et al., The study lasted for 5 days: from postoperative day (POD) 3 to POD... | PMC10013951 | |
Masking and intervention | The group allocation information was sealed an envelope and given to the acupuncturist. The surgeons, principal investigators, study staff, data analysts, and the participants were blinded to grouping. Using the sham electroacupuncture design in the previous literature(Liu et al., In SA group, noninserted sham needles ... | PMC10013951 | ||
Clinical assessment | depression, Depression, NRS, pain | SECONDARY | Nonsteroidal anti‐inflammatory drug was used for analgesia, and supplementary dosage could be administered if needed. No additional analgesic medication was asked for in both EA and SA groups throughout the study. All patients underwent rs‐fMRI scan twice. The demographic information and clinical scale data (dependent ... | PMC10013951 |
Rs‐fMRI data acquisition | The rs‐fMRI data were acquired using a Clinical 1.5 Tesla whole body MR imager (United Imaging, Shanghai, China). Although our previous clinical trial (Kang et al., | PMC10013951 | ||
Data processing and analyzing | PMC10013951 | |||
Statistical analysis | Clinical outcomes were analyzed using a statistical package for windows version 25 (SPSS, IBM Inc., Chicago, IL). A single‐factor ANOVA/two‐sample | PMC10013951 | ||
ALFF analysis | The data was processed by the Data Processing Assistant for rs‐fMRI (Restplus) based on Statistical Parametric Mapping 12 (SPM 12, The blood oxygen level‐dependent time series for each voxel was converted to the frequency domain with fast Fourier transform. The square root of the power spectrum was computed and average... | PMC10013951 | ||
Correlation analysis | The EA‐stimulation difference (EA_ POD 7 vs. POD 3) and group difference (HCs vs. patients at POD 3) were chosen as the regions of interest (ROI). The mean values in the ROI between the two groups were analyzed using the receiver operating characteristic curves. Pearson's correlation coefficients were calculated to ind... | PMC10013951 | ||
RESULTS | PMC10013951 | |||
Baseline characteristics | Totally, 38 patients (20 in EA group, 18 in SA group) completed the two rs‐fMRI scans (baseline and after 5‐day treatment). Forty HCs completed one rs‐fMRI scan. Due to excessive head movement (>3 mm) in scan, 7 patients and 8 HCs were excluded (Figure Folw chart of screening, randomization and intervention. SA, sham‐a... | PMC10013951 | ||
Clinical outcomes | Depression | Table Clinical outcome measurements in the EA and SA groupsEA, electroacupuncture; SA, sham‐acupuncture; NRS, numerical rating scale; SDS, Self‐Rating Depression Scale. | PMC10013951 | |
ALFF analysis | calcarine fissure | CORTEX | Compared with HCs, all patients at POD 3 had significantly lower ALFF in the right middle frontal gyrus (MFG), right supplementary motor area (SMA), bilateral precuneus, right calcarine fissure and surrounding cortex (CAL), and left triangular part of inferior frontal gyrus (IFGtriang) (Table Comparisons of ALFF values... | PMC10013951 |
Correlation between ALFF and pain intensity after intervention | Depression, NRS | The EA‐stimulation difference (EA_ POD 7 vs. POD 3) and group difference (HCs vs. patients at POD 3) as shown by ALFF overlapped in bilateral precuneus, which was chosen as the ROI. Correlation analysis revealed that the change (POD 7–POD 3) in ALFF of bilateral precuneus were negatively correlated with the change of N... | PMC10013951 | |
Complications and adverse events | liver or kidney injury, infection, hematoma, skin ulcer | ADVERSE EVENTS, INFECTION, HEMATOMA, SKIN ULCER | All incisions were healed by the first intention. No skin ulcer, hematoma, infection, liver or kidney injury, or other adverse events was observed. | PMC10013951 |
DISCUSSION | head movements, pain, TKA, depression, Morton et, EA reduced | CORTEX | The transmission of pain in the central nervous system is highly complicated and involves multiple brain regions (Kim et al., We found that patients had lower ALFF in right MFG, right SMA, bilateral precuneus, right CAL, and left IFGtriang following TKA (preintervention), compared with HCs without any pain symptoms. MF... | PMC10013951 |
CONCLUSION | acute pain, TKA, pain | In conclusion, the functional activities in the right MFG, right SMA, bilateral precuneus, right CAL, and left IFGtriang in patients with acute pain after TKA decreased. EA on four acupoints (Futu, Zusanli, Yinglingquan, and Yanglingquan) can increase the functional activities of right cuneus, right angular gyrus, MOG,... | PMC10013951 | |
AUTHOR CONTRIBUTIONS | LBX | BXK, CZ, and JM conceived the study; BXK drafted the study; HQW, XLG, HX, SZ, CXG, and XRX recruited the participants. XYA and JX collected clinical data. MMD and CZ were responsible for statistical analyses and tables. LBX and JS have primary responsibility for the final content. All authors contributed to writing and... | PMC10013951 | |
CONFLICT OF INTEREST STATEMENT | The authors declare that they have no conflict of interest. | PMC10013951 | ||
ETHICS STATEMENT | This study was approved by the Ethics Committee of Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine and was in accordance with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. Written informed consent to participate was obtained from all of the ind... | PMC10013951 | ||
TRIAL REGISTRATION | The trial was registered in Chinese Clinical Trial Registry (ChiCTR2000033778). | PMC10013951 | ||
PEER REVIEW | The peer review history for this article is available at | PMC10013951 | ||
ACKNOWLEDGMENTS | We are grateful to the participants who volunteered to participate in this research. | PMC10013951 | ||
DATA AVAILABILITY STATEMENT | The data sets used and analyzed during the current study are available from the corresponding author on reasonable request. | PMC10013951 | ||
REFERENCES | PMC10013951 | |||
Background | Ciprofol is a novel 2, 6-disubstituted phenolic derivative anesthetic that binds to the gamma-aminobutyric acid-A receptor. | PMC10147789 | ||
Aim | To determine the equally potent dose of ciprofol compared with propofol as an induction agent for general anesthesia in patients undergoing selective surgery, and to assess its safety. | PMC10147789 | ||
Method | ADVERSE EVENTS, SECONDARY | A total of 109 patients undergoing selective non-emergency, non-cardiothoracic or non-neurosurgical surgery requiring tracheal intubation for general anesthesia were enrolled. Ten patients per group were assigned to ciprofol-0.3, 0.4 and 0.5 mg/kg, and propofol-2.0 or 2.5 mg/kg groups, respectively to receive an intrav... | PMC10147789 | |
Results | The success rates were 100% for all 5 groups. The mean time to MOAA/S ≤ 1 and the time to loss of the eyelash reflex were not different among the 5 groups, regardless of whether a top-up dose was needed. There were no significant differences in the incidences and severity of AEs in the dose ranges investigated of cipro... | PMC10147789 | ||
Conclusion | The efficacy and safety of a single bolus dose of ciprofol-0.5 mg/kg for the general anesthesia induction in selective surgery patients was comparable to that of propofol-2.0 mg/kg. | PMC10147789 | ||
Trial registration | Clinicaltrials.gov, NCT03698617, retrospectively registered. | PMC10147789 | ||
Supplementary Information | The online version contains supplementary material available at 10.1007/s11096-022-01529-x. | PMC10147789 | ||
Keywords | PMC10147789 | |||
Impact statements |
Propofol is commonly used for procedural sedation, but since it has the disadvantage of a narrow therapeutic index, alternative sedation drugs with improved drug dosing properties are desirable.Ciprofol is a novel drug for procedural sedation and general anesthesia with a potency about 4–5 times higher than propofol, ... | PMC10147789 | ||
Introduction | Propofol is commonly used for procedural sedation [Ciprofol emulsion (HSK3486), a 2, 6-disubstituted phenol derivative [We assumed that ciprofol would have a similar success rate to propofol for the induction of general anesthesia and here we also provide guidance for its the clinical applications. | PMC10147789 | ||
Aim | Based on previous phase 2 results, in this phase 2 study, we aimed to: (1) determine the equally potent dose of ciprofol compared with propofol as an induction agent for general anesthesia in patients undergoing selective surgery; and (2) to assess its safety. | PMC10147789 | ||
Ethics approval | WEST | The study was approved by the Institutional Review Board (IRB) of Peking University First Hospital (Approval No. 2016-46; December 28th, 2016), West China Hospital, Sichuan University (Approval No. 2017-32; January 15th, 2018) and all other participating medical centers. Prior written informed consent was obtained from... | PMC10147789 | |
Method | PMC10147789 | |||
Study design and patients | This was a phase 2a, 7-center, open-labeled, non-randomized and positive controlled clinical trial. The study consisted of two parts: part 1, dose escalation and part 2, dose expansion. The trial was registered at clinicaltrials.gov (NCT03698617).The inclusion criteria for participants were: 18–65 years old; non-pregna... | PMC10147789 | ||
Part I: Dose escalation | In a previous phase 1 study, the results indicated that ciprofol 0.4 mg/kg, administered as a single i.v. bolus dose, was suitable for inducing general anesthesia in healthy adults. Therefore, in this phase 2a study, we chose 3 doses of ciprofol (0.3, 0.4, 0.5 mg/kg) and 2 doses of propofol (2.0, 2.5 mg/kg). The plan w... | PMC10147789 | ||
For top-up doses and numbers selection | The sedation level was assessed using the Modified Observer’s Assessment of Alertness/Sedation scores (MOAA/S) [ | PMC10147789 | ||
Part II: Dose expansion | Upon completion of the part I study, a part 2 study was performed. Based on the results of the 5 groups (n = 10 for each group the study started with), an additional 20 patients were planned to be enrolled in each of the ciprofol-0.3, 0.5 mg/kg and propofol-2.0 mg/kg groups, respectively. | PMC10147789 |
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