title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Using the model to develop a mHealth intervention | We conducted the mHealth intervention programmes under the guidance of the conceptual framework. Also, we adopted the same conceptual framework to design the intervention strategies which were similar in the constructs but different in detailed content of care needs for the two groups of patients. Use of the conceptual... | PMC10014612 | ||
Follow-up assessment | Follow-up assessments were performed at baseline and 12 weeks after enrollment based on intention-to-treat principles for participants. Each assessment included BP measurement using the provided wearable BP monitor, measurement of waist and hip circumference, height and weight, and questionnaire survey. | PMC10014612 | ||
Outcomes | The primary outcomes were change in SBP and DBP, and the co-primary outcomes were change in waist and hip circumference, height and weight. The second outcomes were change in self-reported CHPS, self-efficacy, and quality of life. | PMC10014612 | ||
Ethical consideration | RECRUITMENT | The study protocol was approved by the ethics committee of School of Health Sciences, Wuhan University in China (Ethical approval number: 2019YF2054). At the process of recruitment, clear explanations about the study objection were provided to all the participants and written informed consent was obtained. | PMC10014612 | |
Statistical analysis | hypertension | REGRESSION, SECONDARY, HYPERTENSION, CONCOMITANT DISEASE | According to the results of our protocol, after the mobile platform management, the BP compliance rate of patients was more than 70%. According to the epidemiological survey conducted by Lin (We sought to recruit at least 134 patients to have 90% power to detect a 5-mm Hg difference in SBP between treatment arms, with ... | PMC10014612 |
Results | PMC10014612 | |||
Participants | From Nov 2017 to Jul 2018, we screened 200 participants, of whom 148 met eligibility criteria and randomly divided into two equal groups. Eight participants from the intervention group and 6 participants from the control group were lost to follow-up because they could not attend the scheduled meetings despite being con... | PMC10014612 | ||
Baseline characteristics | hypertension, HC | HYPERTENSION | Demographic and socioeconomic characteristics, systolic blood pressure (SBP), diastolic blood pressure (DBP), BMI, waist circumference (WC), hip circumference (HC), hypertension compliance, self-efficacy, physical health and mental health in the intervention group were similar to those of the control group participants... | PMC10014612 |
Blood pressure | hypertension | SECONDARY, HYPERTENSION, CONCOMITANT DISEASE | At baseline, the mean (SD) SBP was 152.59 (23.44) mmHg in the intervention group and 148.85 (20.70) mmHg among controls. After 12 weeks of follow-up, the mean (SD) SBP decreased by 8.52 (19.73) mmHg in the intervention group and by 1.25 (12.47) mmHg in the control group (between-group difference, −7.265 mm Hg; 95% CI, ... | PMC10014612 |
Waist and hip circumference | At baseline, the mean (SD) WC was 91.42 (12.92) cm in the intervention group and 90.37 (9.45) cm in the control group. After 12 weeks of follow-up, the mean (SD) WC decreased by 2.14 (2.61) cm in the intervention group and by 0.25 (0.61) cm in the control group (between-group difference, −1.89 cm; 95% CI, −2.53 to −1.2... | PMC10014612 | ||
Hypertension compliance | hypertension | HYPERTENSION, CONCOMITANT DISEASE | At baseline, the mean (SD) hypertension compliance was 46.70 (6.69) in the intervention group and 46.46 (6.89) among controls. After 12 weeks of follow-up, the mean (SD) hypertension compliance increased by 7.35 (7.31) in the intervention group and by 3.01 (4.92) in the control group (between-group difference, 4.334; 9... | PMC10014612 |
Self-efficacy | hypertension | HYPERTENSION, CONCOMITANT DISEASE | At baseline, the mean (SD) self-efficacy was 59.21 (10.44) in the intervention group and 57.84 (11.71) among controls. After 12 weeks of follow-up, the mean (SD) hypertension compliance increased by 12.89 (11.95) in the intervention group and by 5.43 (10.54) in the control group (between-group difference, 7.47; 95% CI,... | PMC10014612 |
Quality of life | hypertension | HYPERTENSION, CONCOMITANT DISEASE | At baseline, the mean (SD) physical health was 49.52 (10.10) in the intervention group and 49.59 (9.11) in the control group, and the mean (SD) mental health was 41.68 (9.39) in the intervention group and 40.12 (10.30) in the control group. After 12 weeks of follow-up, the mean (SD) physical health increased by 12.21 (... | PMC10014612 |
Discussion | hypertension, cardiovascular disease | SECONDARY, HYPERTENSION, CARDIOVASCULAR DISEASE | To our knowledge, this study is the first randomized controlled trial to assess mHealth intervention to improve cardiovascular factors and promote healthier lifestyle behaviors among individuals at high risk of cardiovascular disease in low-resource rural settings in China. This study aimed to evaluate the effects of m... | PMC10014612 |
Conclusions | Despite the popularity of smartphone health-related apps has increased quickly, there has been a lack of rigorous studies which including a clinically important outcome ( | PMC10014612 | ||
Data availability statement | The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author. | PMC10014612 | ||
Ethics statement | The studies involving human participants were reviewed and approved by the Ethics Committee of the School of Public Health, Wuhan University. The patients/participants provided their written informed consent to participate in this study. | PMC10014612 | ||
Author contributions | RECRUITMENT | ZY conceived the study and completed the original draft preparation. ZY and TX collected data. TX provided the recruitment resources. WQ reviewed, edited the final draft, and received the funding. All authors contributed to the article and approved the submitted version. | PMC10014612 | |
Conflict of interest | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. | PMC10014612 | ||
Publisher's note | All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or ... | PMC10014612 | ||
References | PMC10014612 | |||
Background and objective | CM, cutaneous melanoma, psoriasis | CUTANEOUS MELANOMA, PSORIASIS | Edited by: Giuseppe Murdaca, University of Genoa, ItalyReviewed by: Koshy Nithin Thomas, Sanjay Gandhi Post Graduate Institute of Medical Sciences (SGPGI), India; Masahiro Yoshikawa, Nihon University School of Medicine, Japan†These authors have contributed equally to this workExisting cross-sectional and retrospective ... | PMC10368886 |
Methods | CM, psoriasis | REGRESSION, PSORIASIS | We performed a bidirectional two-sample Mendelian randomization analysis using summary statistics from genome-wide association studies of psoriasis and CM among individuals of predominantly European ancestry. Mendelian randomization–Egger regression, inverse variance weighting, Mendelian Randomization Pleiotropy RESidu... | PMC10368886 |
Results | CM, psoriasis | PSORIASIS | Genetically predicted psoriasis was a significant risk factor for CM (odds ratio, 1.69; 95% confidence interval, 1.15–2.48; P = 0.025). In contrast, no association was observed between genetically predicted CM and psoriasis. | PMC10368886 |
Conclusion | cutaneous melanoma, CM, psoriasis | CUTANEOUS MELANOMA, PSORIASIS | Our findings corroborated the existence of genetically predicted psoriasis increases risk of CM. Enhanced early screening of cutaneous melanoma in patients with psoriasis may improve clinical burden. However, we did not find evidence for a causal link from CM to psoriasis, so further studies are required to elucidate t... | PMC10368886 |
Introduction | CM, psoriasis | MINOR, DISEASE, PSORIASIS | At present, there is controversy regarding whether the risk of CM in patients with psoriasis is higher than that in the general population (Traditional observational epidemiological studies face many challenges in discovering disease etiology and inferring causality, such as reverse causal associations, potential confo... | PMC10368886 |
Materials and methods | PMC10368886 | |||
Data sources | cancers, CM, psoriasis | CANCERS, PSORIASIS | The GWAS summary statistics for psoriasis were derived from data published by FinnGen Consortium R9. This study used the “psoriasis” phenotype. The GWAS of psoriasis included 373,338 Finnish adult subjects, including 9,267 cases and 364,071 controls, which excluded subjects with other cancers. Age, sex, top 10 major co... | PMC10368886 |
Instrumental variable | We use the following five criteria to select instrumental variables (IV). First, the SNP–phenotype association level must reach a genome-wide significance threshold (P< 5*10 | PMC10368886 | ||
Statistical analysis | MR, CM, psoriasis | REGRESSION, PSORIASIS | In the present study, we evaluated the causal relationship between psoriasis and CM using various methods, including inverse variance weighting (IVW), MR–Egger regression, MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO), weighted mode, and weighted median. IVW, also known as the inverse variance weighting method, is... | PMC10368886 |
Results | PMC10368886 | |||
Psoriasis to CM | CM, psoriasis | PSORIASIS | As shown in Instrumental variables used in MR analysis of the association between psoriasis and CM.MR analysis of the causal relationship between genetically predicted psoriasis and CM. Cochran’s IVW and MR–Egger Q test showed no significant heterogeneity among these IVs ( | PMC10368886 |
CM to psoriasis | CM, psoriasis | PSORIASIS | We obtained seven SNPs (P< 5 * 10MR analysis of the causal relationship between genetically predicted CM and psoriasis. | PMC10368886 |
Discussion | melanoma, human melanoma, CM, psoriasis | MELANOMA, PSORIASIS | To our knowledge, this study was the first attempt to explore the causal relationship between psoriasis and CM using the summary statistics of FinnGen Alliance R9 and the large GWAS meta-analysis conducted by Matthew et al. (Most current studies on the effect of psoriasis on CM are observational cross-sectional studies... | PMC10368886 |
Strengths and limitations | MR, melanoma, CM, psoriasis | ERYTHRODERMIC PSORIASIS, PUSTULAR PSORIASIS, MELANOMA, PSORIASIS, ARTHRITIC PSORIASIS, PSORIASIS VULGARIS, PSORIATIC ARTHRITIS, REGRESSION | This study had several advantages. To determine the causal relationship between psoriasis and CM without the interference of confounding factors, we performed bidirectional MR analysis. Bidirectional Mendelian randomization analysis is an extension of standard Mendelian randomization analysis. Compared with the latter,... | PMC10368886 |
Conclusion | cutaneous melanoma, CM, psoriasis | CUTANEOUS MELANOMA, PSORIASIS | Our results confirmed genetically predicted psoriasis increases risk of CM. Enhanced early screening of cutaneous melanoma in patients with psoriasis may improve clinical burden. In addition, although the reverse MR estimation does not support the causal relationship from CM to psoriasis, it cannot be ruled out that CM... | PMC10368886 |
Data availability statement | The original contributions presented in the study are included in the article/ | PMC10368886 | ||
Ethics statement | We did not need further ethical approval for this study because we used data from published studies that had the appropriate ethics committees’ approval. | PMC10368886 | ||
Author contributions | NZ: Conceptualization, Methodology, Software, Investigation, Visualization, Writing an original draft. PG: Methodology, Investigation. MT: Investigation, experiment. FY: Methodology, Investigation. TZ: Data Provision, Methodology. RM: Conceptualization, Writing - original draft, Funding acquisition, Supervision. All au... | PMC10368886 | ||
Acknowledgments | We thank all the researchers for providing their GWAS data. We also thank the participants and researchers of the FinnGen study. | PMC10368886 | ||
Conflict of interest | The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest. | PMC10368886 | ||
Publisher’s note | All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or ... | PMC10368886 | ||
Supplementary material | The Supplementary Material for this article can be found online at: Click here for additional data file. | PMC10368886 | ||
References | PMC10368886 | |||
Background | sepsis, ARDS | SECONDARY, CRITICAL ILLNESS, SEPSIS, ARDS, ACUTE RESPIRATORY DISTRESS SYNDROME | Two acute respiratory distress syndrome (ARDS) trials showed no benefit for statin therapy, though secondary analyses suggest inflammatory subphenotypes may have a differential response to simvastatin. Statin medications decrease cholesterol levels, and low cholesterol has been associated with increased mortality in cr... | PMC10053133 |
Methods | sepsis, Sepsis, ARDS | ACUTE RESPIRATORY DISTRESS SYNDROME, SEPSIS, REGRESSION, SEPSIS, ARDS | Secondary analysis of patients with ARDS and sepsis from two multicenter trials. We measured total cholesterol from frozen plasma samples obtained at enrollment in Statins for Acutely Injured Lungs from Sepsis (SAILS) and Simvastatin in the Acute Respiratory Distress Syndrome (HARP-2) trials, which randomized subjects ... | PMC10053133 |
Results | Sequential Organ Failure, sepsis, shock | SEPSIS, SHOCK | There were 678 subjects with cholesterol measured in SAILS and 509 subjects in HARP-2, of whom 384 had sepsis. Median cholesterol at enrollment was 97 mg/dL in both SAILS and HARP-2. Low cholesterol was associated with higher APACHE III and shock prevalence in SAILS, and higher Sequential Organ Failure Assessment score... | PMC10053133 |
Conclusions | sepsis-related ARDS | Cholesterol levels are low in two cohorts with sepsis-related ARDS, and those in the lowest cholesterol quartile are sicker. Despite the very low levels of cholesterol, simvastatin therapy seems safe and may reduce mortality in this group, though rosuvastatin was associated with harm. | PMC10053133 | |
Graphical abstract | PMC10053133 | |||
Supplementary Information | The online version contains supplementary material available at 10.1186/s13054-023-04387-9. | PMC10053133 | ||
Keywords | PMC10053133 | |||
Background | ARDS | ACUTE RESPIRATORY DISTRESS SYNDROME, CRITICAL ILLNESS, ARDS | Acute respiratory distress syndrome (ARDS) is a heterogeneous condition with high mortality and lacks targeted medical therapies [Interestingly, the effect of statin medications on lipid profiles as it pertains to outcomes in critical illness has not been well studied. Cholesterol has proposed roles in normal lung phys... | PMC10053133 |
Methods | PMC10053133 | |||
Population | Sepsis, ARDS | SEPSIS, SECONDARY, ARDS | This is a secondary analysis of randomized clinical trial data from the ARDS Network Statins for Acutely Injured Lungs from Sepsis (SAILS) trial [ | PMC10053133 |
Cholesterol measurement | Total cholesterol levels were obtained from frozen plasma samples which were collected at the time of enrollment in the clinical trials. Total cholesterol was measured in the year 2016 for SAILS samples using the Infinity Cholesterol Liquid Stable Reagent (TR2242, from ThermoFisher), and the Amplex Red Cholesterol Assa... | PMC10053133 | ||
Statistical analysis | non-sepsis, sepsis-induced ARDS, illness, ARDS | REGRESSION, SECONDARY, ARDS | To test our hypothesis that mortality would be higher in subjects with lower cholesterol who received a statin, individuals were assigned to a “low cholesterol” or “not-low cholesterol” group defined by lowest quartile of total cholesterol versus the remaining three quartiles. To our knowledge, there is no universally ... | PMC10053133 |
Results | PMC10053133 | |||
Population | sepsis, pneumonia, infections, ARDS | SEPSIS, ARDS, PNEUMONIA, INFECTIONS | Of the 745 subjects enrolled in SAILS, 678 subjects had sufficient plasma samples available to obtain baseline total cholesterol levels, and thus were included in this analysis. In the SAILS trial, the predominant cause of sepsis-associated ARDS was pneumonia, with the remaining cases largely consisting of other infect... | PMC10053133 |
Association of low cholesterol with illness severity and mortality | sepsis | SEPSIS | As shown in Table Baseline characteristics of SAILS and HARP-2 cohorts stratified by cholesterol level* Shock/vasopressor requirement was significantly higher in low cholesterol group in both cohorts(Only HARP-2 patients with sepsis are includedValues are presented as | PMC10053133 |
Discussion | illness, sepsis, high-density lipoprotein reduction, ARDS | HYPOCHOLESTEREMIA, SIDE EFFECT, SECONDARY, SEPSIS, ARDS | This study first investigated the association between total cholesterol levels with mortality and secondly the response to statin therapy in patients with ARDS and sepsis through a secondary analysis of the SAILS and HARP-2 trials. These cohorts had remarkably low baseline cholesterol levels, and low cholesterol correl... | PMC10053133 |
Conclusions | illness, ARDS | ARDS | In conclusion, absolute values of cholesterol are low in these two ARDS cohorts, and the lowest levels of cholesterol are associated with greater severity of illness. There were differential effects of rosuvastatin and simvastatin in ARDS subjects with low cholesterol. We found rosuvastatin was associated with higher m... | PMC10053133 |
Acknowledgements | Not applicable. | PMC10053133 | ||
Author contributions | CMO | SMP, MAM, RMB, DFM, CMO, and AJR collaborated in conception of this study. JG and JC performed data acquisition. SMP, ARM, and AJR performed the data analysis. SMP and AJR were primarily responsible for drafting of the work, and all authors participated in revision and approval of the final draft. All authors read and ... | PMC10053133 | |
Funding | ARDS | LUNG, BLOOD, HEART, ARDS | NIH/NHLBI R01 HL112747, HL111024, HL51856, HL55330, Global Research Laboratory grant, NIH/NCATS KL2-TR-002385. The SAILS trial was conducted by the ARDS Network and supported by a grant from the National Heart, Lung, and Blood Institute, National Institutes of Health (HHSN268200 536165C-536179C), and the Investigator-S... | PMC10053133 |
Availability of data and materials | MAY, THORACIC | The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. Data from this article have been presented in part at the American Thoracic Society Conference in 2020 (May 15–20, 2020) [ | PMC10053133 | |
Declarations | PMC10053133 | |||
Ethics approval and consent to participate | ARDS | SECONDARY, ARDS | The SAILS clinical trial (ClinicalTrials.gov Identifier: NCT00979121, accepted September 16, 2009) was approved by the Institutional Review Board at each of the 44 enrolling hospitals in the NHLBI ARDS Clinical trial network, and assent for participation was collected from patients and their families as part of SAILS t... | PMC10053133 |
Consent for publication | Not applicable. | PMC10053133 | ||
Competing interests | The authors declare that they have no competing interests. | PMC10053133 | ||
References | PMC10053133 | |||
Background | Central venous catheter | Central venous catheter (CVC) insertion using simulation is an essential skill for anesthesiologists. Simulation training is an effective mean to master this skill. Given the large number of residents and the limited duration of training sessions, the active practice time is limited and residents remain observers of th... | PMC10714635 | |
Methods | COMPLICATIONS | Incoming anesthesia residents were randomized to use an OT (i.e. procedural skill-based checklist) (OT+) or not (OT-) when observing other residents during a simulation bootcamp. The primary outcome was a composite score (total 60 points) evaluating CVC procedural skills rated immediately after the training. This score... | PMC10714635 | |
Results | COMPLICATIONS | Immediately after training, the composite score was similar between the two groups: 45.3 ± 4.2 (OT+, Analysis of the logbook showed no difference between groups. No serious complications were reported. | PMC10714635 | |
Conclusions | The use of a procedural task-based OT by incoming anesthesia residents and used during CVC insertion simulation training was not associated with better learning outcomes, neither immediately after the session nor when re-evaluated 1 month later. The training at least once on simulator of all residents could limit the i... | PMC10714635 | ||
Supplementary Information | The online version contains supplementary material available at 10.1186/s12909-023-04915-9. | PMC10714635 | ||
Keywords | PMC10714635 | |||
Background | Learning how to insert a central venous catheter (CVC) is essential for anesthesia residents and the use of simulation is recommended [The social learning theory proposed by Bandura and adapted to simulation states that vicarious learning occurs when observing others, one gets an idea of how behaviors are produced and ... | PMC10714635 | ||
Methods | PMC10714635 | |||
Study description | This prospective and randomized study was conducted at the simulation center of Paris-Saclay University (LabForSIMS). Approval had been obtained from the Research Ethics Committee of the French Society of Anesthesia and Intensive Care Medicine (SFAR, CERAR: IRB 00010254–2021 – 196). The trial has been registered on Cli... | PMC10714635 | ||
Assessment method | failure or complications | PNEUMOTHORAX | The primary outcome was a composite learning score [Secondary outcomes included a separate analysis of each item of the composite score. During the first month of their clinical rotation, each resident recorded in a logbook the number of CVCs inserted (all access types), specifically those placed in the internal IJV. F... | PMC10714635 |
Statistical analysis | Assuming that an expected mean composite score would be 48 out of 60 in the control group, using a standard deviation of 6 points out of 60, and considering that an improvement of one standard deviation (difference accepted for studies in education [The composite score was compared immediately after training between th... | PMC10714635 | ||
Results | PMC10714635 | |||
Inclusion | In November 2021, 96 anesthesia residents participated in the study and were included (Fig. Characteristics of participantsSignificant if Each resident was an active participant at least once and observed the performance of their peers six times (according to the mean number of residents in each group). | PMC10714635 | ||
Internal jugular vein (IJV) catheter insertion during clinical practice | During the first month, residents in the two groups had inserted a similar number of IJV catheters: 2.9 ± 1.7 and 3.4 ± 2 respectively (OT+: Number of CVC placed during the first month after training in the two groupsSignificant if Outcomes related to the first internal jugular catheters placed in clinical practice aft... | PMC10714635 | ||
Discussion | RECRUITMENT, DECAY | In this study, an observer tool (OT), based on chronological technical steps, was used with the aim of improving the training of incoming anesthesia residents to place a central venous catheter (internal jugular vein) during a simulation session. The use of an OT was not associated with better learning outcomes, immedi... | PMC10714635 | |
Conclusion | An observer tool based on the technical steps needed to be performed when placing an internal jugular vein central catheter was used during training of incoming anesthesia residents during a simulation session but was not associated with better learning outcomes immediately after and 1 month later. Further studies are ... | PMC10714635 | ||
Acknowledgements | We would like to acknowledge the technicians of LabForSIMS simulation center (B Bech and A Renault) who were of great help in preparing and managing the sessions and all the instructors who were involved in the training sessions. The authors would also like to thank Prof. Patrice Forget, MD, PhD, Clinical Chair (full p... | PMC10714635 | ||
Authors’ contributions | DB and AB designed the study, ST, BG, YB, LR, KK, CD, BJ, MBL, DB and AB performed the inclusion. ST and AB analyzed and interpreted the data. DB and AB wrote the main manuscript text. All authors reviewed the manuscript. | PMC10714635 | ||
Funding | Not applicable. | PMC10714635 | ||
Availability of data and materials | The datasets generated during and/or analyzed during the current study are available in the | PMC10714635 | ||
Declarations | PMC10714635 | |||
Ethics approval and consent to participate | This study was approved by the Ethical Committee for Research of the French Society of Anesthesia and Intensive Care Medicine (SFAR, CERAR: IRB 00010254–2021 – 196). All participants gave written informed consent. All methods were performed in accordance with the relevant guideline and regulation. | PMC10714635 | ||
Consent for publication | Not applicable. | PMC10714635 | ||
Competing interests | The authors declare no competing interests | PMC10714635 | ||
References | PMC10714635 | |||
Background | This study aimed to assess the effects of health education and community-level participatory interventions at the community level and the use of community maternal health promoters on the utilization of maternal health care services in poor rural settings of northern Ghana. | PMC10403908 | ||
Methods | REGRESSION | A randomized controlled survey design was conducted from June 2019 to July 2020 in two rural districts of northern Ghana. A multistage cluster sampling technique was used to select the participants. Data were collected from a repeated cross-sectional household survey. Descriptive analysis, bivariate and covariates adju... | PMC10403908 | |
Results | At post-intervention, the two groups differed significantly in terms of ANC (p = 0.001), skilled delivery (SD) (p = 0.003), and PNC (p < 0.0001). Women who received health education on obstetric danger signs had improved knowledge by 50% at the end of the study. Women who received the health education intervention (HEI... | PMC10403908 | ||
Conclusions | This study suggests that the use of health education and participatory sessions led by community-based facilitators could be a potentially effective intervention to improve the knowledge of women about obstetric danger signs and encourage the uptake of maternity care services in resource-poor settings of Ghana. | PMC10403908 | ||
Supplementary Information | The online version contains supplementary material available at 10.1186/s12889-023-16376-2. | PMC10403908 |
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