title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Radiographic measurement | tooth | CREST | The CBCT images were collected using the Planmeca 3D Imaging System (field-of-view of 8 cm (D) × 8 cm (H), resolution 0.16 mm, Planmeca, Finland). After being exported as digital imaging and communications in medicine (DICOM) files, the data were analyzed using planning software (Nobel Clinician, Nobel Biocare, Sweden)... | PMC10579201 |
Histomorphological examination | Tissue biopsies were immersed in 10% neutral formalin solution for 24 h with the trephines.Thereafter, samples were dehydrated with alcohol gradients after flushing, and embedded with polymethyl methacrylate. The samples were sectioned opposite to the long axis of the biopsy, and five tissue sections of 600 µm thicknes... | PMC10579201 | ||
Statistical analysis | ± | Categorical data are expressed as frequencies and percentages, and continuous data as mean (± standard deviation, SD) or median and interquartile range (IQR) (25th–75th percentile). Analysis was performed in the per-protocol (PP) dataset, that is, all patients who were randomized, received the intervention, and complet... | PMC10579201 | |
Results | Of the 40 patients recruited for the study, 4 (10%) were excluded due to protocol violations (prohibited medication history, significantly exceeding the follow-up time-point limit, and severely defective bone), 2 of them from the natural healing group, and 1 patient each from the rhBMP-2/BioCaP/β-TCP and β-TCP groups, ... | PMC10579201 | ||
GV changes on CBCT images | In the first CBCT scan (baseline), there were no statistically significant differences in GVs between the rhBMP-2/BioCaP/β-TCP and β-TCP groups (Table Initial GV in β-TCP and rhBMP-2/BioCaP/β-TCP groupComparison of CBCT data of the GV change in three groupsComparison of CBCT data of the GV change in β-TCP group and RhB... | PMC10579201 | ||
Histomorphological results | The percentage of new bone area at the 3 mm point was statistically significant different in the three study groups, with higher values in the rhBMP-2/BioCaP/β-TCP group (21.18% ± 7.62% in the rhBMP-2/BioCaP/β-TCP group, 13.44% ± 6.03% in the β-TCP group, and 9.49% ± 0.08% in controls). Also, the median (min, max) valu... | PMC10579201 | ||
Discussion | bone loss, tooth | ADHESION, BONE LOSS | This study used CBCT scanning and histological examination to evaluate degradation and new bone formation associated with the use of rhBMP-2/BioCaP/β-TCP and β-TCP as filling materials in socket preservation. CBCT scanning showed that there was a greater GV decrease in the rhBMP 2/BioCaP/β-TCP group than in the β-TCP g... | PMC10579201 |
Acknowledgements | We thank Frederieke Monchen and Isa Massee for collecting CBCT data, Dr. Naichuan Su for statistical data analysis, and Marta Pulido, MD, for editing the manuscript. | PMC10579201 | ||
Author contributions | YS: writing—original draft and visualization; CX and MW: writing—review and editing; HP: performed in trial design and management; YW and LW: writing—review; YL: conceptualization; supervision; writing—review and editing. | PMC10579201 | ||
Funding | This work was supported by the NWO grant (No. 729001041) and the Dutch ZonMW grant LSH2TREAT (No. 436001004). | PMC10579201 | ||
Data availability | The datasets used and/or analysed during the current study are available from the corresponding author upon reasonable request. | PMC10579201 | ||
Declarations | PMC10579201 | |||
Ethical approval and consent to participate | The study was approved by the Clinical Research Ethics Committees of the Academic Center for Dentistry Amsterdam (code ACTA 202061), Vrije Universiteit Amsterdam, the Netherlands and Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University, School of Medicine (code SH9H-2019-T231-4), China. | PMC10579201 | ||
Consent for publication | Written informed consent was obtained from all participants. | PMC10579201 | ||
Competing interests | The authors declare that they have no competing interests. | PMC10579201 | ||
References | PMC10579201 | |||
Keywords | PMC10208731 | |||
Palavras-chave | PMC10208731 | |||
Introduction | PTB, sPTB | PRETERM BIRTH, PRETERM DELIVERY |
Multiple gestations are at higher risk for preterm birth (PTB), and neonatal morbidity and mortality, and their incidence has been in a rising trend since many of them are associated with assisted reproduction treatments.
The use of risk factors to identify women at higher risk of preterm delivery is part of the prev... | PMC10208731 |
Methods | fetal malformation, PTB, cholestasis, sPTB | VAGINAL BLEEDING, CONTRACTIONS, LIVER DISEASE, PREGNANCY COMPLICATIONS, CHOLESTASIS, PLACENTA PREVIA, THROMBOEMBOLISM, REGRESSION, DILATION, PRETERM BIRTH |
We performed an ancillary analysis using a cohort strategy analysis of all twin pregnancies included in the P5 Trial (Pessary Plus Progesterone to Prevent Preterm Birth Study – Trial registration RBR-3t8prz, approved by the Brazilian National Review Board/CONEP – number 1.055.555) to describe Brazilian populational cu... | PMC10208731 |
Results | PTB, sPTB, abortion | OBESE |
A total of 253 from 8,168 women were included in this analysis. We excluded 71 women due to missing information, and 7844 singleton women (
Patient enrolment flowchart.
The incidence of twin pregnancy in the P5 screening phase was 3.5%, with 157 dichorionic diamniotic twins (62%), and 96 monochorionic diamniotic twi... | PMC10208731 |
Values of percentile 5, 10, 25, 50, 75, 90, and 95 for the cervical length according to gestational age at measurement | sPTB |
As a presumable consequence, considering two gestational ages intervals at measurement (18–20 vs. 21–22 weeks), we identified an increase in sensitivity to predict sPTB < 37 during 21 to 22 weeks (
| PMC10208731 | |
Discussion | PTB, sPTB |
Our study provides Brazilian CL distribution curves from 18 to 22 + 6 weeks in asymptomatic twin gestations. The CL 10
The mean CL identified in our study and the PTB rate are very similar to previous Brazilian studies focused on twin gestations. A prospective cohort involving 341 patients with CL measurement between... | PMC10208731 | |
Conclusion | PTB | A cutoff point of CL ≤ 20 mm can be interesting to identify short cervix in Brazilian twin pregnancies. However, in Brazilian asymptomatic twin pregnancies, CL does not show a good performance to predict PTB. Furthermore, the available treatments for PTB in twins do not support a CL screening program in Brazil. | PMC10208731 | |
Contributions | JP | TV Silva: design, investigation, data collection, data analysis, data curation, methodology, writing, and review & editing. AB Pinheiro: review & editing. MS França: investigation, data collection, and data analysis. KF Marquart: investigation, data collection, and data analysis. JP Argenton: statistics and data analys... | PMC10208731 | |
References | PMC10208731 | |||
Background | The authors have declared that no competing interests exist.The World Health Organization recommends that primaquine should be given once weekly for 8-weeks to patients with | PMC10482257 | ||
Methods | Within the context of a multicentre, randomised clinical trial of two primaquine regimens in | PMC10482257 | ||
Results | G6PD DEFICIENCY | Between July 2014 and November 2017, 42 male and 8 female patients were enrolled in Afghanistan (6), Ethiopia (5), Indonesia (19), and Vietnam (20). G6PD deficiency was confirmed by genotyping in 31 patients: Viangchan (14), Mediterranean (4), 357A-G (3), Canton (2), Kaiping (2), and one each for A | PMC10482257 | |
Conclusions | PQ8W was highly effective in preventing | PMC10482257 | ||
Trial registration | This trial is registered at ClinicalTrials.gov ( | PMC10482257 | ||
Author summary | Fifty patients with | PMC10482257 | ||
Data Availability | All data are in the manuscript and/or | PMC10482257 | ||
Materials and methods | PMC10482257 | |||
Ethics statement | Ethics approval was obtained from the following national and local committees and authorities: The Human Research Ethics Committee of the Northern Territory Department of Health (HREC), Australia, the Islamic Republic of Afghanistan, Ministry of Public Health, Institutional Review Board, Afghanistan, the National Resea... | PMC10482257 | ||
Trial design, study site, conduct and ethics | gastrointestinal symptoms, parasitaemia, abdominal pain, nausea, vomiting | INFECTIOUS DISEASES, ALLERGY, ADVERSE EVENTS, DRUG WITHDRAWAL, EVENTS, SEVERE ANEMIA, BLOOD | The clinical trial design and methodology have been described previously [G6PDd patients were treated with supervised primaquine (blister-packed 7.5 & 15 mg tablets, Centurion Laboratories, Vadodara, India), at a target dose of 0.75mg base/kg per week (At enrolment, a medical history was taken, a physical examination w... | PMC10482257 |
G6PD deficiency assessment and genotyping | G6PD deficiency | G6PD DEFICIENCY | At the two Indonesian sites, patients with an FST result indicating G6PD deficiency had their enzyme activities quantified by spectrophotometry (Trinity Biotech, Ireland), processed within 7 days of sampling [Patient’s G6PDd status was confirmed by genotyping for local variants known to be associated with reduced enzym... | PMC10482257 |
Statistical methods & data management | parasitaemia | REGRESSION, RECURRENCE, G6PD DEFICIENCY | Data were entered from standardised case record forms and analysed using Stata v16.0 (StataCorp, College Station, TX). Negative binomial regression adjusted for follow up time was used to estimate the incidence rate of recurrence outcomes and Kaplan Meier survival estimates were used to assess the incidence risk of rec... | PMC10482257 |
Results | Between July 20, 2014, and November 25, 2017, 50 patients (42 [84%] males) with G6PDd and microscopy confirmed | PMC10482257 | ||
Trial profile. | PMC10482257 | |||
Baseline characteristics of patients enrolled into the study. | The baseline characteristics of patients enrolled at each site are presented in | PMC10482257 | ||
G6PD activity and genotyping | G6PD deficiency | G6PD DEFICIENCY | Genotyping of G6PD variants was conducted on all but one patient from Afghanistan who had a missing blood sample. Seventeen patients were wild type at the loci tested (See In South Sumatra, the G6PD activity of the six patients diagnosed with G6PD deficiency by FST ranged from 1.4 to 52% (Of the 31 patients enrolled in... | PMC10482257 |
G6PD variants identified in patients enrolled into the study. | 202G | *1 male in Ethiopia genotyped as AF2 (202G>A) and was categorized as A+ and not confirmed as deficient. Enzyme activities are presented in | PMC10482257 | |
Efficacy | parasitaemia, aparasitaemic | The initial response to treatment was rapid in all patients. After 24 hours, 88% (44/50) were aparasitaemic and 92% (45/49) were afebrile. By 48 hours, all patients had cleared their peripheral parasitaemia and were afebrile. Two Vietnamese patients had recurrent symptomatic The incidence rate of | PMC10482257 | |
Efficacy endpoints. | PMC10482257 | |||
Haematological profile | Overall, the median Hb concentration fell after starting treatment with the lowest concentration reported on D7 (12.2 g/dL, range 8.3–16.6). The Hb concentration rose thereafter to exceed the median baseline Hb on D28 ( | PMC10482257 | ||
Changes in haemoglobin concentrations (g/dL) over time in all patients identified as G6PD deficient by the fluorescent spot test. | Footnote: Purple dotted lines show individual patient Hb profiles.The Hb concentrations over time by G6PD status are shown in | PMC10482257 | ||
Distribution of haemoglobin concentrations (g/dL) over time during follow up by G6PD status. | Footnote: Boxes represent 25 | PMC10482257 | ||
Hemoglobin Profile by Treatment Arm. | Two patients had falls in Hb exceeding 5 g/dL ( | PMC10482257 | ||
Relationship between haemoglobin at baseline and day 7 as A) fractional change and B) absolute change, by G6PD status. | PMC10482257 | |||
Tolerability | No patient vomited their medication within 1 hour of administration. During the first week ( | PMC10482257 | ||
Symptoms elicited from symptom questionnaires. | diarrheal, abdominal pain, anorexia, nausea, vomiting | ANOREXIA | * Composite of any of the following: nausea, vomiting, anorexia, diarrheal or abdominal pain | PMC10482257 |
Discussion | anemia, acute disease, parasitaemia, G6PD deficiency, hemolysis, anorexia | EVENT, RECRUITMENT, ANEMIA, ACUTE DISEASE, G6PD DEFICIENCY, HEMOLYSIS, ANOREXIA | Our study represents the largest study to date on the use of the 8-week primaquine regimen for the radical cure of Defining antirelapse efficacy of primaquine and tafenoquine is confounded by the frequency and timing of hypnozoite reactivation and recurrent parasitaemia, which vary with hypnozoite load, and parasite st... | PMC10482257 |
Supporting information | PMC10482257 | |||
Statistical analysis plan. | (PDF)Click here for additional data file. | PMC10482257 | ||
Literature review of clinical trials treating patients with weekly primaquine regimens. | (DOCX)Click here for additional data file. | PMC10482257 | ||
Information about study sites. | (DOCX)Click here for additional data file. | PMC10482257 | ||
List of Ethics Review Boards and Regulatory Agencies. | (DOCX)Click here for additional data file. | PMC10482257 | ||
Weekly primaquine dosing. | (DOCX)Click here for additional data file. | PMC10482257 | ||
Dosing table for dihydroartemisinin piperaquine used in Indonesia. | (DOCX)Click here for additional data file. | PMC10482257 | ||
Baseline Characteristics of all patients stratified by site. | (DOCX)Click here for additional data file. | PMC10482257 | ||
Study data. | (XLSX)Click here for additional data file.We wish to express our sincere gratitude to the patients for volunteering to join this study and to the nurses and laboratory staff. For the purpose of open access, the author has applied a CC BY public copyright license to any Author Accepted Manuscript version arising from th... | PMC10482257 | ||
References | PMC10482257 | |||
Background | CARDIOPULMONARY | Cardiopulmonary resuscitation skill have a direct impact on its success rate. Choosing the right method to acquire this skill can lead to effective performance. This investigation was conducted to compare the effect of Real-time feedback and debriefing by video recording on basic life support skill in nursing students. | PMC9878936 | |
Methods | This quasi-experimental study was performed on 67 first year nursing students. First, a theoretical basic life support (BLS) training session was held for the all participants, at the end of session the pre-test was taken. Students were randomly assigned to two groups. A 4-hour practical BLS training session was conduc... | PMC9878936 | ||
Results | Results showed a significant difference between mean (SD) of debriefing by video recording group in pre-test and post-test ( | PMC9878936 | ||
Conclusions | Both real-time feedback and debriefing by video recording were effective on basic life support skill. | PMC9878936 | ||
Keywords | PMC9878936 | |||
Introduction | cardiovascular disease, cardiac arrest | CARDIOVASCULAR DISEASE, CARDIAC ARREST | The burden of cardiovascular disease and the sudden increase in the number of cardiac arrests is one of the most important health problems in the world, which imposes high costs on the health care system of countries every year [Resuscitation education is a necessary element of skills training for nurses who are likely... | PMC9878936 |
Methods | This study was quasi-experimental (pretest-posttest). Research sample in this study included 67 first year nursing students studying in Mashhad School of Nursing and Midwifery in the academic year 2019–2020 who were selected by convenience sampling method. Inclusion criteria were: no clinical work experience, no partic... | PMC9878936 | ||
Measurement and instrument | HEART | The instruments used in the research were demographic information questionnaire, Kolb learning style inventory and BLS checklist with 18 items. This researcher-made checklist was prepared after reviewing samples of similar foreign and domestic checklists and based on the latest changes in the clinical guidelines of the... | PMC9878936 | |
Intervention | After obtaining permission from the ethics committee of Mashhad University of Medical Sciences (MUMS) and approval of the Nursing and Midwifery Education Department, students’ informed written consent was obtained. The participants were included in the study in an accessible manner according to the inclusion criteria. ... | PMC9878936 | ||
Data analysis | The collected data were analyzed using SPSS software version 25. Kolmogorov-Smirnov and Shapiro Wilk tests were used to determine the normal distribution of data. Mann-Whitney test was used to compare the mean basic life support skill between the two groups of real-time feedback and debriefing by video recording before... | PMC9878936 | ||
Discussion | Findings of the study showed that basic life support skill significantly increased due to the application of both real-time feedback training and Debriefing by Video Recording methods, while there was no significant difference between the two training methods.Regarding the effect of real-time feedback method, our study... | PMC9878936 | ||
Acknowledgements | This paper is extracted from a master’s thesis in Medical Surgical Nursing approved by the School of Nursing and Midwifery, Mashhad University of Medical Sciences. The authors would like to thank all the undergraduate nursing students who participated in the study. | PMC9878936 | ||
Authors’ contributions | MG, JM, SR. M, and TP conceptualized and designed the study. MG acquired the data. MG and SR. M analyzed the data. MG and SR. M interpreted analyzed data. MG and TP drafted the manuscript and tables. MG, JM, SR. M, and TP revised the manuscript. All authors have reviewed and approved the manuscript. | PMC9878936 | ||
Funding | The Mashhad medical university of medical sciences (MUMS) (grant number 980568, to Tayebe pourghaznein). | PMC9878936 | ||
Availability of data and materials | All data generated or analyzed during this study are included in this published article. | PMC9878936 | ||
Declarations | PMC9878936 | |||
Ethics approval and consent to participate | The study has been performed in full accordance with the Declaration of Helsinki and was approved of the ethics committee of School of Nursing And Midwifery - Mashhad University of Medical Sciences, code of ethics (IR.MUMS.NURSE.REC.1398.062). The researcher explained the purpose of the study and the method of work to ... | PMC9878936 | ||
Consent for publication | Not applicable. | PMC9878936 | ||
Competing interests | The authors declare that they have no competing interests. | PMC9878936 | ||
References | PMC9878936 | |||
Subject terms | papillary thyroid microcarcinoma, tumour, PTMC | REGRESSION, TUMOUR, DELAYED HEALING | In order to provide clinical references for the RFA procedure and to study the pivotal factors affecting the recovery time of radiofrequency ablation (RFA) in patients with papillary thyroid microcarcinoma (PTMC), 176 patients with low-risk intrathyroidal PTMC were included in this research. We randomly divided the who... | PMC10439129 |
Introduction | primary thyroid cancer, PTC, Papillary thyroid microcarcinoma, PTMC | THYROID, PAPILLARY THYROID CANCER | Papillary thyroid microcarcinoma (PTMC) is a form of papillary thyroid cancer (PTC) with a maximum diameter of 1 cmAs an ultrasound-guided interventional technique, RFA is a less invasive alternative to surgeryUltrasound images of PTMC locoregional lymph nodes status in different treatment stages. (The 2017 RFA guideli... | PMC10439129 |
Results | PMC10439129 | |||
Patient cohort baseline | PTMC | RECRUITMENT | In this study, we obtained the medical records of patients with low-risk intrathyroidal PTMC from the Second Affiliated Hospital Zhejiang University School of Medicine. There were 208 patients meeting the above inclusion criteria and were all pathologically diagnosed with PTMC by fine-needle aspiration samples and unde... | PMC10439129 |
LASSO regression and feature selection | REGRESSION | Least absolute shrinkage and selection operator (LASSO) regression analysis prevents overfitting and has very good performance in selecting variablesThe prognostic factors of RFA focus absorption time were selected by the least absolute shrinkage and selection operator (LASSO) regression model. ( | PMC10439129 | |
Construction and diagnosis of absorption time nomogram | PTMC | REGRESSION | By using the aforementioned four variables, we constructed the PTMC RFA absorption model by Cox regression, and a nomogram prediction model is shown in Fig. The construction and diagnosis t-test of the absorption time nomogram. ( | PMC10439129 |
Accuracy of the nomogram | To evaluate the accuracy of the nomogram, we used the “Survival ROC” package to draw the ROC curve of the training (Fig. Test of the accuracy of the nomogram. ( | PMC10439129 | ||
Decision curve analysis | Decision curve analysis (DCA) was used to evaluate the clinical net benefit of the predictive model | PMC10439129 | ||
RFA zone absorption time analysis | In our data, the patient’s RFA zone absorption time ranged from 3 to 48 months, with an average absorption time of 12.8 months. We defined that patients whose RFA absorption time was greater than 12 months as the “high-risk group”, and the rest were defined as the “low-risk group”. Nextly, we applied the log-rank test ... | PMC10439129 | ||
Discussion | skin burns, dysphonia, infection, tumour, endocrine malignancy, injury to vital neck organs, PTMC, gastric cancer | RECURRENCE, DISEASE, INFECTION, TUMOUR, NECK HEMATOMA, REGRESSION, GASTRIC CANCER | Many studies have shown that RFA has a good therapeutic effect in patients with PTMC. However, the description of the RFA treatment process in patients with PTMC in clinical guidelines is relatively empirical. The RFA power used for PTMC patients are varied from several watts to dozens watts among different medical ins... | PMC10439129 |
Methods | PMC10439129 | |||
Study population | thyroid lesions, dysphagia, voice, hoarseness, intraoperative or postoperative reactions, extrathy, hematoma, PTMC | DYSPHAGIA, NEUROLOGICAL COMPLICATION, HYPOPARATHYROIDISM, RECRUITMENT, LYMPH NODE METASTASIS, LEAKAGE, HEMATOMA, LYMPHATIC CYSTS | This retrospective study was approved by the Institutional Review Board (IRB) of the Second Affiliated Hospital Zhejiang University School of Medicine (SAHZU). The requirement for the informed consent from the patients was waived by the IRB of SAHZU, and all experiments were performed in accordance with relevant guidel... | PMC10439129 |
Protocol of CEUS | CEUS examinations were conducted utilizing a Resona 7 machine (Mindray Company, China) equipped with UWN | PMC10439129 | ||
Protocol of RFA | tumor | INTRAOPERATIVE COMPLICATIONS, TUMOR, TUMOR RECURRENCE, RESIDUAL TUMOR | Radiofrequency energy was generated using a VIVA radiofrequency generator (STARmed, Goyang, Korea) and an 18-gauge monopolar internally cooled electrode (VIVA; STARmed). Continuous cooling with distilled water circulation prevented overheating of the electrode shaft. The patient was positioned supine with a slightly ex... | PMC10439129 |
US image acquisition | TUMOR RECURRENCE | Before RFA, the ultrasound features of PTMC typically included a hypoechoic nodule with well-defined margins, a taller-than-wide shape, and intranodular vascularity on Doppler ultrasound. After RFA, the ultrasound features of the treated area would vary based on the degree of ablation. Ideally, the treated area should ... | PMC10439129 | |
Construction of the clinical predictive model | tumour | TUMOUR | We collected the following clinical data of the cohorts as potential variables for the predictive model: patient age, sex, the energy of RFA, the average diameter of the original tumour, and RFA range at different time points (1 day after RFA and 1 month after RFA). In addition, the RFA focus absorbtion time of each pa... | PMC10439129 |
Acknowledgements | We are very grateful to professor Pintong Huang, who is the cheif of Radiology Department of Zhejiang University School of Medicine, designing the study. And we are also very grateful to the Department of Ultrasound in Medicine, The Second Affiliated Hospital Zhejiang University for accumulating and collecting the clin... | PMC10439129 |
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