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Conclusions | knee arthroplasty, VTE | In summary, six hours a day may be the optimal duration of applying VFP for the prevention of VTE in patients receiving hip and knee arthroplasty. However, further studies are needed to validate these findings. | PMC10691185 | |
Acknowledgements | TRANSFORMATION | We appreciated the funding support of the Military Medical Transformation Project of PLA General Hospital (ZH19009), the Innovation Project of the National Clinical Research Center for Orthopaedics and Sports Rehabilitation of China (2021-NCRC-CXJJ-ZH-36). | PMC10691185 | |
Authors’ contributions | Conception and design of the study: YG and SG. Data processing and analysis: SG and ML. Interpretation of the results: SG, ML, JL, YC, DK, and YG. Drafting of the article: SG, ML, YC, YG, and DK. Critical revision of the article for important intellectual content: SG, ML, JL, YC, WYL, MZ, HZ, MM, DK, and YG. DK and YG ... | PMC10691185 | ||
Funding | TRANSFORMATION | This study was funded by the Military Medical Transformation Project of PLA General Hospital (ZH19009), the Innovation Project of the National Clinical Research Center for Orthopaedics and Sports Rehabilitation of China (2021-NCRC-CXJJ-ZH-36). We declare that the funds, grants, or other support were not used to prepare... | PMC10691185 | |
Data Availability | Data and materials are available upon reasonable request with the permission of the corresponding authors. | PMC10691185 | ||
Declarations | PMC10691185 | |||
Ethics approval and consent to participate | All patients voluntarily participated in the study and written informed consent was obtained from each patient. This study has been approved by the Medical Ethics Committee of Chinese PLA General Hospital (No. 2021-002-01) and the First Affiliated Hospital of Suzhou University (No. 2021053). The study will follow the e... | PMC10691185 | ||
Consent for publication | Informed consent was obtained from all individual participants included in the study. | PMC10691185 | ||
Competing interests | The authors declare that they have no conflict of interest. | PMC10691185 | ||
References | PMC10691185 | |||
Background | GASTRIC NEUROENDOCRINE CARCINOMA, GASTRIC CANCER | Gastric neuroendocrine carcinoma (GNEC) is a rare histology of gastric cancer. The retrospective study was designed to construct and validate a nomogram for predicting the cancer-specific survival (CSS) of postoperative GNEC patients. | PMC10347809 | |
Methods | REGRESSION | Data for 28 patients from the Hangzhou TCM Hospital were identified as the external validation cohort. A total of 1493 patients were included in the SEER database and randomly assigned to the training group (1045 patients) and internal validation group (448 patients). The nomogram was constructed using the findings of ... | PMC10347809 | |
Results | tumor | TUMOR, METASTASIS | Age, gender, grade, T stage, N stage, metastasis, primary site, tumor size, RNE, and chemotherapy were incorporated in the nomogram. The C-indexes were 0.792 and 0.782 in the training and internal verification sets. The 1-, 3-, and 5-year CSS predicted by the nomogram and actual measurements had good agreement in calib... | PMC10347809 |
Conclusion | We developed and validated a nomogram to predict 1-, 3-, and 5-year CSS for GNEC patients after surgical resection. This well-performing model could help doctors enhance the treatment plan. | PMC10347809 | ||
Keywords | PMC10347809 | |||
Introduction | Gastric cancer, heterogeneous malignancy, tumor, AJCC, Cancer | GASTRIC CANCER, TUMOR, CANCER | Gastric cancer (GC) is a highly heterogeneous malignancy with several pathologies exhibiting markedly varied molecular patterns, tumor behavior, and prognoses [American Joint Committee on Cancer (AJCC) TNM staging system has played an essential role in predicting the prognosis of GNEC [Based on the Surveillance, Epidem... | PMC10347809 |
Materials and methods | PMC10347809 | |||
Data source and patient selection | ONCOLOGY, DISEASES | The data was retrieved from the SEER database during 2010–2015 and analyzed retrospectively. External validation data was obtained from the Hangzhou TCM Hospital between January 2012 and December 2016. This research was carried out in line with the Helsinki Declaration. Participation in this study did not need written ... | PMC10347809 | |
Clinicopathological variables | tumor, T stage, cardia, AJCC | TUMOR | The following characteristics were extracted from the SEER database: year of diagnosis, gender, age, race, marital status, grade, AJCC stage, T stage, N stage, M stage, primary site, tumor size, regional nodes examined (RNE), surgery, radiation therapy, chemotherapy, survival time and vital status. Patients were catego... | PMC10347809 |
Statistical analysis | NRI | REGRESSIONS | All patients were randomized into two groups with a 7:3 ratio. The training group was employed to construct the nomogram, while the internal and external validation groups were applied to validate it. Both univariate and multivariate Cox regressions were performed to calculate the significant parameters (P < 0.05). A p... | PMC10347809 |
Results | PMC10347809 | |||
Clinicopathological characteristics | 1493 GNEC patients were enrolled and divided into the training group (1045 patients) and the internal validation group (448 patients). The 28 patients from the Hangzhou TCM Hospital who made up the external validation cohort were identified. The demographic and clinical characteristics of the patients from the SEER dat... | PMC10347809 | ||
Univariate and multivariate cox regression analysis | tumor | REGRESSION, TUMOR, METASTASIS | The univariate Cox regression performed in the training group indicated that age, gender, grade, T stage, N stage, metastasis, primary site, tumor size, RNE, and chemotherapy were significant prognostic parameters for GNEC patients (P < 0.05). The important variables identified by univariate Cox regression were then in... | PMC10347809 |
Development and internal validation of the nomogram | NRI | REGRESSION | Finally, ten variables screened by multivariate Cox regression were applied to develop the nomogram for predicting the 1-, 3-, and 5-year CSS in GNEC patients (Fig.
A predictive nomogram for postoperative GNEC patientsThe C-indexes were 0.792 (95% CI: 0.770–0.813) and 0.782 (95% CI: 0.749–0.815), respectively, for the... | PMC10347809 |
New Risk Stratification | GNEC patients were divided into three risk cohorts based on the examination of the X-tile software: low risk (46.0 < total points < 204.5), middle risk (204.5 < total points < 330.2), and high risk (330.2 < total points < 437.6; Fig.
Cut-off point for risk stratification selected using X-tile
KM analyses of postoperat... | PMC10347809 | ||
External validation of the nomogram | Based on the patient’s data acquired from our institution, external validation was performed to further verify the model’s effectiveness. The ROC curves demonstrated good prediction performance (1-, 3-, and 5-year AUC were 0.85, 0.86, and 0.94, Fig.
Results of the external validation cohort. | PMC10347809 | ||
Discussion | cancer, tumor, irresponsiveness | REGRESSION, CANCER, TUMOR, METASTASIS | Currently, the low incidence rate and high heterogeneity hindered further investigation of GNEC [Based on the univariate and multivariate Cox regression analysis, ten parameters (age, gender, grade, T stage, N stage, metastasis, primary site, tumor size, RNE, and chemotherapy) significantly affecting CSS in postoperati... | PMC10347809 |
Limitation | METASTASES | The current study included various limitations due to the nature of the database, which should be considered when interpreting the results. To begin, because this was a retrospective study, selection bias was unavoidable. Second, the SEER database lacked information on precise data on performance status, comorbidities,... | PMC10347809 | |
Acknowledgements | Not applicable. | PMC10347809 | ||
Authors’ contributions | Lou YF designed the study; Song X performed the major statistical analysis and drafted the manuscript. Xie YY collected the data and searched the literature. All authors contributed to the article and approved the final version of the manuscript. | PMC10347809 | ||
Funding | Not applicable. | PMC10347809 | ||
Data Availability | The datasets created and evaluated during this project are housed in the SEER database ( | PMC10347809 | ||
Declarations | PMC10347809 | |||
Ethics approval and consent to participate | We certified that all methods were carried out in line with the Helsinki Declaration. Because the patient data obtained from the SEER database is publicly accessible, no ethical approval was required. The Hangzhou TCM Hospital’s Ethics Committee evaluated and authorized the experiment involving human subjects. The ethi... | PMC10347809 | ||
Consent for publication | Not applicable. | PMC10347809 | ||
Competing interests | The authors declare no competing interests. | PMC10347809 | ||
References | PMC10347809 | |||
ABSTRACT | malaria, NL63, OC43, coronavirus disease 2019 | CORONAVIRUS DISEASE 2019, SARS-COV-2 INFECTION, MALARIA, FOUNDER, CORONAVIRUS, SEVERE ACUTE RESPIRATORY SYNDROME | The authors declare a conflict of interest. The authors report no competing interests to this work. A.H.K. reports receiving consulting fees from Roche. D.J.S. reports AliquantumRx Founder and Board member with stock options (macrolide for malaria), Hemex Health malaria diagnostics consulting and royalties for malaria ... | PMC9973272 |
KEYWORDS | PMC9973272 | |||
OBSERVATION | OC43, NL63, SARS-CoV-2 RBD, coronavirus disease 2019 | CORONAVIRUS DISEASE 2019, MAY, CORONAVIRUS, CORONAVIRUS, HEAT | The influence of preexisting antibodies to the four endemic human coronaviruses (ehCoV) (229E, OC43, NL63, and HKU1) on severe (hospitalization) coronavirus disease 2019 (COVID-19) outcomes has not been fully characterized (The prospective association of severe COVID-19 with elevated ehCoV antibody levels at illness on... | PMC9973272 |
Data availability. | OC43, NL63 | MAY | The data sets generated during and/or analyzed during the current study are available from the corresponding author upon reasonable request.Individual control plasma, sorted by date of donation during the collection period of the early treatment trial from 1 May to 30 September, for 229E (A), HKU1 (B), NL63 (C), and OC... | PMC9973272 |
ACKNOWLEDGMENTS | Cancer, Aaron A.R., S. Allen, malaria, Ascada | INFECTIOUS DISEASES, FOUNDER, ALLERGY, MALARIA, ROTH, PAXTON, ROBINSON, CANCER | A. H. Karaba and D. J. Sullivan had full access to all the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis.S. L. Klein, A. L. Cox, A. H. Karaba, and D. J. Sullivan contributed to the conceptualization and design. All authors contributed to acquisition, analy... | PMC9973272 |
REFERENCES | PMC9973272 | |||
Objective: | stroke | STROKE | to evaluate the effect of nursing home care interventions on the quality of life in family caregivers of aged stroke survivors. | PMC9886075 |
Method: | stroke, stroke-related | STROKE | a Randomized Clinical Trial, blinded for outcome evaluation. Forty-eighty family caregivers of aged stroke survivors participated in the study. The Intervention Group received three home visits by nurses one month after hospital discharge to provide stroke-related education (i.e., how to access health services and perf... | PMC9886075 |
Results: | the caregivers were mainly women, children, or spouses. The caregivers in the Intervention Group and Control Group did not significantly differ in terms of their Overall Quality of Life at baseline. There was no interaction effect between group allocation and Overall Quality of Life(p=0.625) over time. However, there w... | PMC9886075 | ||
Conclusion: | the intervention exerted a statistically significant effect on the quality of life of family caregivers with respect to social relationships and autonomy. | PMC9886075 | ||
Trial registration: | NCT02807012. | PMC9886075 | ||
Resumo | PMC9886075 | |||
Objetivo: | avaliar o efeito de intervenção educativa domiciliar de enfermagem na qualidade de vida de cuidadores familiares de idosos sobreviventes de acidente vascular cerebral (AVC). | PMC9886075 | ||
Método: | alta | Ensaio Clínico Randomizado, cego para avaliação de resultados. Quarenta e oito cuidadores familiares de idosos sobreviventes de AVC participaram do estudo. O Grupo de Intervenção recebeu três visitas domiciliares de enfermeiros, um mês após a alta hospitalar, para fornecer educação relacionada ao AVC (como acessar os s... | PMC9886075 | |
Resultados: | os cuidadores eram principalmente mulheres, filhos ou cônjuges. Os cuidadores do Grupo Intervenção e do Grupo Controle não diferiram significativamente em termos de Qualidade de Vida Geral no início do estudo. Não houve efeito de interação entre a alocação do grupo e a Qualidade de Vida Geral (p=0,625) ao longo do temp... | PMC9886075 | ||
Conclusão: | a intervenção apresentou efeito estatisticamente significativo na qualidade de vida dos cuidadores familiares no que diz respeito às relações sociais e autonomia. | PMC9886075 | ||
Registro do ensaio clínico: | NCT02807012. | PMC9886075 | ||
Resumen | PMC9886075 | |||
Objetivo: | evaluar el efecto de intervenciones de atención domiciliaria de enfermería sobre la calidad de vida en cuidadores familiares de adultos mayores sobrevivientes de accidentes cerebrovasculares. | PMC9886075 | ||
Método: | DEL | Ensayo Clínico Aleatorizado, cegado para la evaluación de los desenlaces. Los participantes del estudio fueron 48cuidadores familiares de adultos mayores sobrevivientes de accidentes cerebrovasculares (ACV). El Grupo Intervención recibió tres visitas domiciliarias a cargo de enfermeros un mes después del alta hospitala... | PMC9886075 | |
Resultados: | DEL | en su mayoría, los cuidadores fueron mujeres, hijos o cónyuges. Los cuidadores de los grupos Intervención y Control no presentaron diferencias significativas en términos de su Calidad de Vida general de base. La intervención no ejerció ningún efecto entre la asignación a los grupos y la Calidad de Vida general(p=0,625)... | PMC9886075 | |
Conclusión: | la intervención ejerció un efecto estadísticamente significativo sobre la calidad de vida de los cuidadores familiares con respecto a las relaciones sociales y a la autonomía. | PMC9886075 | ||
Registro del ensayo: | NCT02807012. | PMC9886075 | ||
Descriptors: | PMC9886075 | |||
Descritores: | PMC9886075 | |||
Descriptores: | PMC9886075 | |||
Highlights | (1) Presents effect related to the caregivers’ quality of life (social and autonomy). (2) Educational interventions should be focused on post-discharge care activities. (3) Educational interventions should be focused on the emotional of family caregivers. (4) The findings provide recommendations for nurses and policyma... | PMC9886075 | ||
Introduction | stroke, death, cerebrovascular disease, Stroke | STROKE, CEREBROVASCULAR DISEASE, STROKE | Stroke is one of the main causes of death worldwide and the most prevalent cerebrovascular disease among aged peopleMany family caregivers feel unprepared to care for stroke survivors, as they rarely receive sufficient training from health professionalsQoL is defined as “the individuals’ perception of their position in... | PMC9886075 |
Method | PMC9886075 | |||
Design | Stroke | STROKE | An RCT, blinded for outcome evaluation. This study is part of a larger RCT called “Nursing Home Care Intervention Post Stroke” (SHARE), registered in ClinicalTrials.gov(NCT02807012). The protocol of this study was methodologically performed and previously published to ensure replicability | PMC9886075 |
Setting | stroke, Stroke | STROKE, STROKE | The study participants were family caregivers of aged stroke survivors from the Stroke Special Care Unit (SCU-Stroke) of Porto Alegre is the capital city of the state of Rio Grande do Sul (Brazil) and is considered the second Brazilian capital with the highest number of older adults, representing 14.05% of the populati... | PMC9886075 |
Population, eligibility criteria and sampling | stroke, disability | STROKE | This study was conducted with family caregivers of stroke survivors aged 60 years old and over. The stroke survivors included in the study were those with a minimum score of 2 (no significant disability despite the symptoms; able to carry out all usual duties and activities) in The Modified Rankin Scale (mRankin)Sample... | PMC9886075 |
Randomization and blinding | Randomization was performed using a list generated by the | PMC9886075 | ||
Control Group | DISEASE | During hospitalization and at discharge, the family caregivers received usual care from a multidisciplinary team in SCU-Stroke. Additionally, they underwent follow-up from their respective health service networks, which typically includes general information about the disease and some aspects inherent to care, such as ... | PMC9886075 | |
Intervention | The IG received usual care and the SHARE intervention, which included three HVs from two trained nurses approximately 14, 21 and 30 days after discharge. The INs engaged in a dialogic process with the family caregivers which, in turn, stimulated reflective thinking and shared answersCaregiver education was provided in ... | PMC9886075 | ||
Study variables and instruments | stroke, ’ | STROKE | The stroke survivor data collected prior to discharge pertained to identification (name, address and contact details), sociodemographic data (age, biological sex, schooling, marital status, family income and professional status) and physical health (type of stroke, comorbidities, mRankin and the FIM scores). The caregi... | PMC9886075 |
Data collection | stroke | MAY, STROKE | The data were collected between May 2016 and July 2018. All caregivers were visited at their homes by two research assistants, the same who collected baseline caregiver QoL data using WHOQOL-BREF and adjunct WHOQOL-OLD. The stroke survivors were also assessed using FIM. Afterwards, a nurse, who was a research team memb... | PMC9886075 |
Statistical analysis | stroke, ’ | STROKE | The analyses were performed with intention to treat (ITT). Regardless of the treatment (if any) they received, all randomized participants were included in the statistical analysis and examined according to the group to which they were originally allocatedThe analyses were conducted using the Statistical Package for th... | PMC9886075 |
Validity and reliability | Death | The Brazilian version of WHOQOL-BREF presented good performance concerning internal consistency (α = 0.91), discriminant validity, criterion validity, concurrent validity and test-retest reliability (correlational coefficient scores above 0.7)The Cronbach’s α coefficients of WHOQOL-BREF in this study at baseline were a... | PMC9886075 | |
Fidelity of the study | The protocol of this study was documented to guarantee reproducibilityAn application guide, containing instructions on how to administer and score WHOQOL and FIM, was made available to the research assistants. All INs had access to the care protocol developedThe HVs were scheduled with the caregivers by phone according... | PMC9886075 | ||
Ethical considerations | prejudice | The participants signed an Informed Consent Form and with assurance of voluntary participation and anonymity. They would be able to withdraw from the study without prejudice, including access to any public health services. No physical harms were anticipated. The study was approved by the institution’s Research Ethics C... | PMC9886075 | |
Results | The RCT diagram according to the Consolidated Standards of Reporting Trials (CONSORT) is shown in
| PMC9886075 | ||
RCT Diagram According to the Consolidated Standards of Reporting Trials(CONSORT) | stroke, ’ | STROKE | The stroke survivors’ sociodemographic characteristics and health conditions are shown in
| PMC9886075 |
Sociodemographic characteristics and health status of the stroke survivors (n=48). PortoAlegre, RS, Brazil, 2018 | *CG = Control Group;
| PMC9886075 | ||
Characteristics of the family caregivers (n=48). Porto Alegre, RS, Brazil, 2018 | *CG = Control Group; The effects of the SHARE intervention on the WHOQOL-BREF scores are presented in There were statistically significant changes in the Social Relationships scores over time. The CG caregivers had a significantly lower QoL between baseline and year 1 (The environmental QoL scores among the CG caregive... | PMC9886075 | ||
Effects of SHARE on the caregivers’ WHOQOL-BREF scores (n=48). Porto Alegre, RS, Brazil, 2018 | *Estimated means ± standard error; The SHARE intervention did significantly affect the caregivers’ WHOQOL-OLD scores(
| PMC9886075 | ||
Effect of SHARE on the family caregivers’ WHOQOL-OLD scores (n=15). PortoAlegre, RS, Brazil, 2018 | *Estimated means ± standard error; | PMC9886075 | ||
Discussion | stroke, ’ QoL deficits | STROKE | This RCT study focuses on the effects of a tailored educational intervention among family caregivers of Brazilian aged stroke survivors. One year after the stroke survivors had been discharged from SCU-Stroke, statistically significant differences were observed in the family caregivers’ Quality of Life. Our most poigna... | PMC9886075 |
Conclusion | stroke | STROKE | The SHARE intervention exerted a statistically significant effect on family caregivers’ QoL with respect to their social relationships and autonomy. Interventions to support physical provision of care and QoL are important. Gains in knowledge about stroke survivor care and care delivery alone are not sufficient. The ca... | PMC9886075 |
References | PMC9886075 | |||
Background | depressive, depression, Cambodian-American, diabetes | DIABETES | Refugees have high levels of psychological distress that hamper lifestyle change efforts. We previously reported that community health educator (CHE) diabetes prevention interventions decreased HbA1c and depressive symptoms among Cambodian-American refugees with depression; this paper reports health behavior outcomes o... | PMC10496245 |
Methods | depression, depressive symptoms, diabetes | DIABETES | Participants were aged 35–75, Khmer speaking, at risk for diabetes, and met study criteria for likely depression by either a) antidepressant medication and/or b) prolonged elevated depressive symptoms. Participants were randomized to one of three CHE interventions: 1) lifestyle intervention called | PMC10496245 |
Results | The | PMC10496245 | ||
Conclusions | depression | CHEs may improve nutrition and physical activity in refugees with depression but more intensive interventions may be required to impact sleep. Improvements in all three behaviors appear to be associated with HbA1c lowering | PMC10496245 | |
Trial registration | ClinicalTrials.gov identifier NCT02502929. | PMC10496245 | ||
Keywords | PMC10496245 | |||
Methods | Diabetes | DIABETES | Diabetes Risk Reduction through Eat, Walk, Sleep and Medication Therapy Management (DREAM) was a randomized, controlled trial to compare the efficacy of EWS vs. EWS + MTM vs social services (SS, control condition). Assessments were at baseline, endpoint (12-months) and follow-up (15-months). The study was pre-registere... | PMC10496245 |
Participants | Diabetes, diabetes | DIABETES, SPECIAL EVENT, DIABETES | DREAM recruited through referrals from clinicians and social service agencies; outreach at large cultural gatherings such as Cambodian new year celebrations; posters at local Khmer businesses; holding special events at relevant temples and churches. Inclusion criteria were: 1) aged 35–75; 2) Cambodian or Cambodian-Amer... | PMC10496245 |
Procedures | CHW data collectors conducted assessments in a private setting at a location of the participant’s choice, either in-home or at a clinic or social service agency. The CHWs administered surveys verbally and recorded responses in Remote Electronic Data Capture (REDCap) [ | PMC10496245 | ||
Randomization | After all components of the baseline assessments were complete (i.e., surveys, anthropometrics and blood pressure, actigraphy, bloodwork), participants were individually randomized using an urn randomization [ | PMC10496245 | ||
Interventions | Participants who were randomized to EWS or EWS + MTM were assigned to receive 3 individual EWS sessions and 24 group EWS sessions delivered by CHEs. The three individual sessions cover behavioral targets included eating no more than 1 small bowl of (brown) rice per meal, walking at least 30 min per day on 6 days per we... | PMC10496245 | ||
Measures | PMC10496245 | |||
EAT behaviors | cardiometabolic disease, shakes | We assessed three domains of nutrition behaviors important for cardiometabolic disease. Using community-based, participatory methods we developed a brief food frequency questionnaire that was tailored for the Cambodian American diet. It focused on the most commonly consumed sources of carbohydrate (rice, rice products ... | PMC10496245 |
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