title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Statistical Analysis | cancer, death | CANCER, RELAPSE | Patients who underwent randomization and for whom residual serum samples were available for measurement of p53-Ab levels were included in this analysis. Relapse and death-related outcomes were assessed according to randomization group (ie, whether supplements were taken) as an intention-to-treat analysis. Effects of vi... | PMC10445201 |
Results | PMC10445201 | |||
Study Population | The study population consisted of 392 patients with levels of p53-Ab measured (260 males [66.3%]; mean [SD; range] age, 66 [10.7; 35-90] years), including 241 patients in the vitamin D group and 151 patients in the placebo group ( | PMC10445201 | ||
Study Flowchart | PMC10445201 | |||
Patient Characteristics | There was detectable p53-Ab in the serum of 142 patients (36.2%), constituting the p53-Ab (+) group, with levels ranging from 0.4 to 1890.0 U/mL, but not in the remaining 250 patients (63.8%), constituting the p53-Ab (−) group. Characteristics of participants in these groups are shown in the | PMC10445201 | ||
Patient Characteristics | Abbreviations: 25(OH)D, 25-hydroxy vitamin D; BMI, body mass index (calculated as weight in kilograms divided by height in meters squared); p53-Ab, anti-p53 antibody.≥0.4 U/mL.<0.4 U/mL.Characteristics of patients who were p53-Ab (+) stratified by intervention are shown in the eTable in | PMC10445201 | ||
Subgroup Analysis of Patients With and Without p53-Ab in Serum | death | In the p53-Ab (+) group, relapse or death occurred in 17 of 86 patients (19.8%) in the vitamin D group and 19 of 56 patients (33.9%) in the placebo group; 5-year RFS was 26 patients (77.2%) in the vitamin D group and 10 patients (60.0%) in the placebo group, indicating no significant difference (HR, 0.57; 95% CI, 0.30-... | PMC10445201 | |
Subgroup Analysis of Patients With and Without Serum Anti-p53 Antibody (p53-Ab) | death | Nelson-Aalen cumulative hazard curves for relapse or death in p53-Ab (+) and p53-Ab (−) groups, assessing patients taking vitamin D vs those taking placebo, were compared using hazard ratios and 95% CIs. | PMC10445201 | |
Serum Anti-p53 Antibody (p53-Ab) Levels by p53 Immunohistochemistry (IHC) Protein Expression | IHC levels were 0 (<1% strong or faint p53 cells in cancerous region; p53-IHC [0]), 1 (1%-10% strong p53 cells in cancerous region; p53 IHC [1+]), 2 (>10%-99% strong p53 cells in cancerous region; p53 IHC [2+]), and 3 (>99% overexpressed p53 cells in cancerous region; p53 IHC [3+]). | PMC10445201 | ||
Analyses in p53-Immunoreactive Subgroup | death | In 80 patients in the p53-immunoreactive subgroup (ie, patients who were p53-Ab [+] and p53-IHC [3+]), relapse or death occurred in 9 of 54 patients (16.7%) in the vitamin D group and 14 of 26 patients (53.8%) in the placebo group; the 5-year RFS was significantly higher in the vitamin D group (13 patients [80.9%]) tha... | PMC10445201 | |
Analysis of p53-Immunoreactive Subgroup | death | IHC indicates immunohistochemistry; p53-Ab, anti-p53 antibody. Nelson-Aalen cumulative hazard curves are presented in the p53-Ab (+) and p53-IHC (3+) subgroup, p53-Ab (−) or p53-IHC (2+, 1+, or 0) subgroup, p53-Ab (+) and p53-IHC-positive subgroup, and p53-Ab (−) or p53-IHC-negative subgroup. Hazard curves for relapse ... | PMC10445201 | |
Discussion | cancer, death | MUTANT, CANCER | In this post hoc analysis of the AMATERASU RCT, p53-IHC grades showed a positive association with serum p53-Ab levels. Additionally, p53-Ab levels were significantly higher in patients who were p53-IHC (+) than those who were p53-IHC (−). Previously, mutant p53 protein that accumulated in cancer cells was reported to b... | PMC10445201 |
Limitations | This study has several limitations. First, this was a post hoc analysis of the AMATERASU RCT, and the number of patients in the p53-immunoreactive subgroup was very small. Second, because analyses assessed a post hoc hypothesis, observer error or bias could have influenced results. Thus, the findings must be considered... | PMC10445201 | ||
Conclusions | digestive tract cancer, cancer, death | CANCER | This post hoc analysis of an RCT found that vitamin D supplementation reduced the risk of relapse or death in the subgroup of patients with digestive tract cancer who were p53 immunoreactive. Findings suggest the importance of developing cancer immunotherapy targeting mutated p53 proteins. | PMC10445201 |
Background | infection, sepsis, Sepsis | INFECTION, SEPSIS, SEPSIS, DYSREGULATED HOST RESPONSE | Sepsis occurs as a result of dysregulated host response to infection. However, cytokine adsorption therapy may restore the balance of proinflammatory and anti-inflammatory mediator responses in patients with sepsis. This study aimed to determine the cytokine adsorption ability of two different types of continuous renal... | PMC10314474 |
Methods | sepsis | SEPSIS, SECONDARY | We performed a randomized controlled trial among sepsis patients undergoing CRRT, who were randomly assigned (1:1) to receive either AN69ST or PMMA-CRRT. The primary outcome was cytokine clearance of hemofilter adsorption (CHA). The secondary endpoints were the intensive care unit (ICU) and 28-day mortalities. | PMC10314474 |
Results | tumor necrosis | TUMOR NECROSIS | We randomly selected 52 patients. Primary outcome data were available for 26 patients each in the AN69ST-CRRT and PMMA-CRRT arms. The CHA of high-mobility group box 1, tumor necrosis factor, interleukin (IL)-8, monokine induced by interferon-γ, and macrophage inflammatory protein were significantly higher in the AN69ST... | PMC10314474 |
Supplementary Information | The online version contains supplementary material available at 10.1186/s40001-023-01184-6. | PMC10314474 | ||
Keywords | PMC10314474 | |||
Background | Sepsis, critically ill, organ dysfunction, infection, AKI | SEPSIS, CRITICALLY ILL, INFECTION, DYSREGULATED HOST RESPONSE, ACUTE KIDNEY INJURY | Sepsis, which is a life-threatening organ dysfunction, is caused by the dysregulated host response to infection [Acute kidney injury (AKI) is significantly associated with a high mortality rate in critically ill patients [ | PMC10314474 |
Methods | PMC10314474 | |||
Trial design and patients | EMERGENCY | This pilot open-label RCT was conducted at the Tertiary Emergency and Critical Care Center of Fukuoka University Hospital (Fukuoka, Japan) according to the Declaration of Helsinki. Our emergency and closed ICU has 32 beds. The trial was registered at the University Hospital Medical Information Network (UMIN000029450), ... | PMC10314474 | |
Interventions and procedures | ® | The PMMA and AN69ST groups were defined based on the PMMA and AN69ST membranes. CRRT was initiated immediately after ICU admission. The patients were randomly assigned (1:1) to the AN69ST or PMMA groups. Random numbers were generated using the Excel random function (Microsoft Japan Co., Ltd., Tokyo, Japan), and patient... | PMC10314474 | |
Data and sample collection | AKI, infection, septic shock | INFECTION, SEPTIC SHOCK, CORONAVIRUS, BLOOD, SEVERE ACUTE RESPIRATORY SYNDROME | The baseline data, including patients’ characteristics such as age, sex, comorbidities, AKI stage on admission, source of infection, and detected microorganism (COVID-19 was diagnosed based on the detection of severe acute respiratory syndrome coronavirus 2 [SARS-CoV-2] on reverse transcription-polymerase chain reactio... | PMC10314474 |
Outcomes | ADVERSE EVENTS | The primary outcome was cytokine CHA. Plasma cytokine clearance was calculated according to the following formula [Secondary endpoints included blood cytokine levels upon admission to the ICU and on days 2–4 and 5–7 after ICU admission, ICU mortality, 28-day all-cause mortality, VAI [Safety and feasibility outcomes inc... | PMC10314474 | |
Statistical analyses | REGRESSION | Data are presented as medians (interquartile ranges) for continuous variables and percentages for categorical variables. We used the Wilcoxon, Steel–Dwass, and Chi-square or Fisher’s exact tests for comparing two groups of continuous variables, multiple comparisons between continuous variables, and comparing categorica... | PMC10314474 | |
Results | PMC10314474 | |||
Safety and feasibility outcomes | ADVERSE EVENTS | No serious adverse events were observed in either group (Additional file | PMC10314474 | |
Discussion | sepsis | SEPSIS | To the best of our knowledge, this study is the first RCT to evaluate the difference in cytokine CHA between the AN69ST and PMMA hemofilters in a clinical setting. We found that AN69ST and PMMA membranes had significantly different cytokine CHA in patients with sepsis in different time points at 2–4 h and 12–24 h after... | PMC10314474 |
Strengths and limitations | septic | The obvious strength of our study is the use of randomization to minimize selection bias. However, this study has some limitations. First, blinding of the interventions was not performed. Second, because this was a pilot, single-center study, generalizability is insufficient. Third, the present study did not have a con... | PMC10314474 | |
Conclusions | sepsis | SEPSIS | Our first pilot RCT showed that AN69ST and PMMA hemofilters have different cytokine CHA ability in patients with sepsis. However, no significant difference was observed in the present pilot clinical study. Therefore, these two hemofilters may have to be used depending on the target cytokine. | PMC10314474 |
Acknowledgements | We would like to thank Editage ( | PMC10314474 | ||
Author contributions | YN, FK, TH, and HI designed the study. HH, SY, KY, KH, and YK performed sample collection and input data. FK advised on statistical findings. YN generated the random allocation sequence; YN, KH, and YK enrolled participants; and HH, SY, and KY assigned participants to interventions. YN, HH, and SY contributed to the st... | PMC10314474 | ||
Funding | Part of this study was supported by Sysmex Corp, which played no role in the study and measured cytokine and HMGB1 concentrations. Furthermore, this study was supported by a grant from the Clinical Research Promotion Foundation (2021). | PMC10314474 | ||
Availability of data and materials | The data that support the findings of this study are available from authors, but restrictions apply to the availability of these data, which were used under license for the current study, and so are not publicly available. Data are however available from the authors upon reasonable request and with permission of the Me... | PMC10314474 | ||
Declarations | PMC10314474 | |||
Ethics approval and consent to participate | This study was approved by the Medical Ethics Review Board of Fukuoka University (approval number: 2017M089) and was performed in line with the principles of the Declaration of Helsinki. All patients or legal representatives provided informed consent. | PMC10314474 | ||
Consent for publication | All patients or legal representatives approved this publication. | PMC10314474 | ||
Competing interests | The authors declare that they have no competing interests. | PMC10314474 | ||
References | PMC10314474 | |||
1. Introduction | ’ | Cities attracting large numbers of tourists increasingly face crowding and public resistance to tourism growth. As a result, governments strive to spread tourists from the best-known attractions to less-visited locations to improve both residents’ and tourists’ quality of life. Evidence of success and best practices he... | PMC10138512 | |
2. Literature Review | PMC10138512 | |||
2.1. Tourism Flows and Overtourism | Knowledge about the impacts of tourism flows on host resident communities is nearly as old as academic research of tourism. In fact, publications such as Turner and Ash’s Golden Hordes [At the same time, the term “overtourism” appeared increasingly often in academic journals [Previous research thus demonstrates that ec... | PMC10138512 | ||
2.2. Conversational Recommender Systems | A conversational recommender system occupies the space between a completely personal conversation with a human being and a completely automated conversation with a chatbot. While personal conversations have long been a staple of DMOs via brick-and-mortar offices, phone lines, and direct messaging on social media, they ... | PMC10138512 | ||
2.3. Tourist Experience | While a comprehensive review of tourist experience is beyond the scope of this article see [There is remarkably little known about how | PMC10138512 | ||
2.4. Our Study—Justification and Approach | ’ emotions | While the technical and user experience value of a recommender system such as Zoey have been well documented in previous research, the application of this technology to overtourism issues has not been studied. If information interventions from recommender systems or more conventional sources actually causes tourists to... | PMC10138512 | |
3. Materials and Methods | PMC10138512 | |||
3.1. Study Design | 342,273 | As we wanted to measure the specific and direct effects of conversational recommender systems and the information therein on vacation behaviors and experiences, we used a an experimental design with random assignment to intervention conditions, which is the only research design that supports conclusions about an interv... | PMC10138512 | |
3.2. Sample | MAY | We used an availability sampling approach during two waves of data collection in May 2021 and late July/early August 2021. For field research in tourism contexts, availability samples being used as probability samples is practically impossible due to the lack of a sampling frame. Even if a sampling frame such as all vi... | PMC10138512 | |
3.3. Measures | PMC10138512 | |||
3.3.1. Location | We tracked location using GPS via the Mobidot mobile application Sesamo. Sesamo passively tracks location in the background using variable frequency based on speed of movement, with a granularity of one second. Accordingly, the application has a low burden on battery and CPU usage of mobile devices. After installing th... | PMC10138512 | ||
3.3.2. Self-Reported Emotion | POSITIVE | We asked participants to report on their daily emotions using a modification of the Scale of Positive and Negative Experience SPANE, [While various emotion scales differ in the specific list of emotions presented, the SPANE is brief and well-balanced between positive and negative emotions. There are four general emotio... | PMC10138512 | |
3.3.3. Experience Evaluation | We measured four dimensions of experience evaluation using single-item measures based on the Net Promotor Score item on intent to recommend [While these item address participants’ evaluations of specific dimensions of their vacation, they do not cover the experience evaluation of the vacation as a goal. To that end, we... | PMC10138512 | ||
3.4. Analyses | We analyzed the data in five stages. First, we described the experience and evaluation variables for the sample as a whole. Then, we examined differences on experience and evaluation between the four conditions (popularity-driven/passive, policy-driven/passive, popularity-driven/conversational, policy-driven/conversati... | PMC10138512 | ||
4. Results | PMC10138512 | |||
4.1. Descriptive Statistics | fits | RECRUITMENT | An initial group of 269 participants filled in the recruitment form and intake questionnaire. Random assignment led to a relatively even division across the four experimental groups (popularity-driven passive n = 71; policy-driven passive n = 65; popularity-driven conversational n = 61; policy-driven conversational n =... | PMC10138512 |
4.2. Differences between Groups | There were remarkably few differences in experiences and outcomes between groups. The groups were statistically similar in positive emotions on vacation (F = 1.028, There were large differences between groups in evaluations of destination information sources. The passive app with either kind of tips earned about a 5 on... | PMC10138512 | ||
4.3. Spatial Distribution between Groups | As a whole, participants moved around the most near their accommodations, but spread out over the entire province of Overijssel, including all its major cities and motorways as well as side roads. On a map showing locations visited by at least one participant from each group (Unlike differences in reported experience a... | PMC10138512 | ||
4.4. Experience over Space | SAID | There were no significant effects of aggregated daily movements at different attraction types on daily positive emotions, within participants. There were modest connections between spatial behavior and negative emotions, however. Days when participants spent relatively more movements at non-priority attractions feature... | PMC10138512 | |
5. Discussion | PMC10138512 | |||
5.1. Theoretical Implications | Our findings show that intervening on information changes tourists’ spatial behavior substantially, but has only limited implications for their experiences, extending existing knowledge in several ways. First, we assert that information provided to tourists firmly belongs in the theoretical discussion about causes and ... | PMC10138512 | ||
5.2. Professional Implications | Our findings suggest that the current trend to shift destination management policy from attracting as many tourists as possible, to spreading tourists away from crowded attractions to less-popular ones, can be implemented by intervening on information delivery. Specifically, at least those tourists who are open to dest... | PMC10138512 | ||
5.3. Limitations and Future Directions | crowding, COVID-19-related lockdowns, ’ behavior | MAY, COLD | During the first wave of data collection (May 2021), museums and restaurants were closed due to COVID-19-related lockdowns. Many people were hoping for some perspective on the situation before booking a vacation. At the last minute, when they might still have booked, the weather turned out to be cold and very rainy. Th... | PMC10138512 |
6. Conclusions | The findings of the present study demonstrate that giving tourists policy-driven information, especially by conversational recommender system, has the potential to spread them away from heavily visited areas to a wider geographic area and specifically to attractions in less-visited areas. Their visitation of urban area... | PMC10138512 | ||
Author Contributions | W.W. | Conceptualization, O.M., R.B., J.K. and W.W.; methodology, O.M. and J.K.; software, R.B., H.M. and O.M.; formal analysis, O.M., M.V., L.d.G. and K.V., resources, W.W. and R.B.; data curation, O.M., H.M. and W.W.; writing—original draft preparation, O.M.; writing—review and editing, O.M., L.d.G., K.V. and H.M.; visualiz... | PMC10138512 | |
Institutional Review Board Statement | BREDA | IThe study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of the Breda University of Applied Sciences with number 2103-01-ADV-02-CC-ZOEY. | PMC10138512 | |
Informed Consent Statement | Informed consent was obtained from all participants. | PMC10138512 | ||
Data Availability Statement | The data used in this study are unavailable for public use due to the privacy sensitivity of location data that may inadvertently occasionally include participants’ travel from their home to their vacation location. | PMC10138512 | ||
Conflicts of Interest | Author 2 (R.B.) is the CEO of Zoey, the recommender system studied in some of the experimental conditions. He contributed to the conceptualization of the study, structuring destination information and delivering the experimental intervention, and to factual description of technology underlying recommender systems to th... | PMC10138512 | ||
References | POSITIVE | Screenshots of conversational (Self-reported differences between groups on (Locations visited by at least one participant from all four groups.Most visited locations.Locations visited exclusively by each of the 2 popularity-driven groups.Locations visited exclusively by each of the 2 policy-driven groups.Difference bet... | PMC10138512 | |
1. Introduction | CVDs, death, premature atherosclerosis, hypercholesterolemia, Hypercholesterolemia, atherosclerosis, fatty deposits | HYPERCHOLESTEROLEMIA, INFLAMMATORY RESPONSES, CARDIOVASCULAR DISEASES, CVD, HYPERCHOLESTEROLEMIA, OXIDATIVE STRESS, PREMATURE ATHEROSCLEROSIS, ATHEROSCLEROSIS, DYSLIPIDEMIA | Probiotics have the potential as a multi-target approach to modulate hypercholesterolemia associated with premature atherosclerosis. Various strains of Hypercholesterolemia is a major risk factor leading to cardiovascular diseases (CVDs), a major cause of death worldwide. High levels of total cholesterol, low-density l... | PMC9921995 |
2. Materials and Methods | PMC9921995 | |||
2.1. Subjects | TCTR | This study was conducted following the rules of the Declaration of Helsinki. The protocol was approved by the Ethical Committee of the Human Experimentation Committee, Research Institute for Health Science (RIHES), Chiang Mai University, Thailand (Project No. 11/64), and the Thai Clinical Trials Registry (TCTR) is TCTR... | PMC9921995 | |
2.2. Study Design and Treatment | BLIND | We conducted a single-center, prospective, randomized, double-blind, placebo-controlled, parallel-group trial. Subjects were kept blind regarding treatments. Blinded investigators performed data interpretation and analysis.Subjects were randomly assigned using block randomization into two groups as follows: (1) | PMC9921995 | |
2.3. Blood Sampling and Biochemical Measurements | inflammation, TG, TNF-α, tumor necrosis | CLOT, TUMOR NECROSIS, INFLAMMATION, BLOOD, OXIDATIVE STRESS | Blood samples were collected in the morning after 12 h fasting at each visit and kept in a test tube to analyze for blood lipid profiles (TG, TC, LDL-C, and HDL-C), serum biochemistry (FBG, blood urea nitrogen (BUN), creatinine, and alanine transaminase (ALT), aspartate transaminase (AST) and alkaline phosphatase (ALP)... | PMC9921995 |
2.4. Statistical Analysis | The sample size of fifty subjects was calculated using the superiority design method (calculating sample size when the outcome measure is a continuous variable) [Statistical analysis was performed using SPSS software version 22 (SPSS Inc., Chicago, IL, USA). Data were ensured using the normal distribution of variables ... | PMC9921995 | ||
3. Results | PMC9921995 | |||
3.1. Characteristics of the Subjects | dyslipidemia | SECONDARY, DYSLIPIDEMIA | A total of 50 hypercholesterolemic subjects were assessed for eligibility, and 4 subjects were excluded due to the presence of secondary dyslipidemia (n = 3) and relocation (n = 1). Subjects were randomly allocated into the Subjects in the The within-group and between-group analysis showed that general characteristics ... | PMC9921995 |
3.2. Effect of L. paracasei TISTR 2593 Supplementation on Blood Safety Parameters | BLOOD | Blood samples were tested for FBG, BUN, creatinine, ALT, AST, ALP, blood electrolytes, and hematology representing safety parameters when repetitively consuming A comparison of within-group and between-group was analyzed, and results are shown in | PMC9921995 | |
3.3. Effect of L. paracasei TISTR 2593 Supplementation on Blood Lipid Profiles | To investigate the effect of | PMC9921995 | ||
3.4. Effect of L. paracasei TISTR 2593 Supplement on Oxidative Stress and Inflammation | inflammation, atherosclerosis, Hypercholesterolemia | INFLAMMATION, ATHEROSCLEROSIS, HYPERCHOLESTEROLEMIA, OXIDATIVE STRESS, PATHOGENESIS | Hypercholesterolemia alters vascular endothelial cell membranes, enhancing oxidative stress and inflammation mediators implicated in the pathogenesis of atherosclerosis [In current results, it was found that subjects who consumed Additionally, a significant difference in the reduction in MDA ( | PMC9921995 |
3.5. Effect of L. paracasei TISTR 2593 Supplement on Adiponectin, apolipoprotein E, and Total Bile acid Level | Regulating glucose and lipid metabolism, cholesterol transportation, and cholesterol execration play an important role in disrupting cholesterol metabolism. Thus, the serum level of adiponectin, apolipoprotein E, and TBA was evaluated to observe the possible effect of Interestingly, the results showed that subjects who... | PMC9921995 | ||
4. Discussion | adiponectin deficiency, atherosclerosis, hypercholesterolemia, endothelial dysfunction | HYPERCHOLESTEROLEMIA, INFLAMMATION, ATHEROSCLEROSIS, INSULIN RESISTANCE, DYSLIPIDEMIA, OXIDATIVE STRESS, ENDOTHELIAL DYSFUNCTION | This present study demonstrated the benefit of Recently, it has been suggested that the gut microbiota and their metabolites play an important role in regulating lipid metabolism and glucose homeostasis [This observation may be attributed to the anti-inflammatory effects of probiotics by inhibiting the release of pro-i... | PMC9921995 |
5. Conclusions | In summary, the current study findings demonstrated that supplementation with | PMC9921995 | ||
Author Contributions | W.W. | Conceptualization, J.K. and P.C.; methodology, J.K. and P.C.; formal analysis, J.K., P.C. and A.P.; investigation, J.K., P.Y., K.B., P.A., S.T. and W.W.; resources, J.S., K.N., P.T., P.P. and P.C.; writing—original draft, J.K. and A.P.; writing—review and editing, J.K., A.P., W.W. and P.C.; supervision, J.K. and P.C.; ... | PMC9921995 | |
Institutional Review Board Statement | The study was conducted in accordance with the Declaration of Helsinki and approved by the Ethical Committee of the Human Experimentation Committee, Research Institute for Health Science (RIHES), Chiang Mai University, Chiang Mai, Thailand (Project No. 11/64). | PMC9921995 | ||
Informed Consent Statement | All study participants provided informed consent. | PMC9921995 | ||
Data Availability Statement | The data supporting the findings of this study are included in this article. | PMC9921995 | ||
Conflicts of Interest | The authors declare no conflict of interest. | PMC9921995 | ||
References | BLOOD | Consort flow diagram.The general characteristics of the subjects. Data were presented as ± standard deviations.Effect of Data expressed as mean ± standard deviations. FBG; Fasting blood glucose, BUN; Blood Urea Nitrogen, ALT; Alanine aminotransferase, AST; Aspartate aminotransferase, ALP; Alkaline phosphatase, WBC; whi... | PMC9921995 | |
Background | colorectal cancer, trauma | COLORECTAL CANCER | During the perioperative period, the surgical stress response induced by surgical trauma tends to cause a decrease in peripheral lymphocytes. Anesthetics could reduce the stress response during surgery and prevent sympathetic nerve overexcitation. The goal of this study was to investigate how BIS-guided anesthetic dept... | PMC10184475 |
Methods | colorectal cancer | BLOOD, COLORECTAL CANCER | A total of 60 patients having elective laparoscopic colorectal cancer surgery were randomly assigned and analyzed (n = 30 for deep general anesthesia, BIS 35, n = 30 for light general anesthesia, BIS 55). Blood samples were collected immediately before anesthesia induction and immediately after operation, 24 h and 5 da... | PMC10184475 |
Results | The CD4+/CD8 + ratio decreased 24 h after surgery in two groups, but the reduction did not differ between the two groups ( | PMC10184475 | ||
Conclusions | colorectal cancer, peripheral T lymphocyte subsets | COLORECTAL CANCER | Despite the fact that patients in deep general anesthesia group had low levels of the IL-6 24 h after surgery, the deep general anesthesia was not associated to a positive effect on patients’ peripheral T lymphocytes during colorectal cancer surgery. We found no evidence that peripheral T lymphocyte subsets and natural... | PMC10184475 |
Trial registration | ChiCTR2200056624 ( | PMC10184475 | ||
Keywords | PMC10184475 | |||
Introduction | cancer, colorectal cancer, CRC, trauma | FUNCTIONAL DISTURBANCE, CANCER, COLORECTAL CANCER, IMMUNOSUPPRESSION | Worldwide, colorectal cancer (CRC) is the third most commonly diagnosed cancer, and the second for mortality [Immunosuppression is commonly observed in patients who underwent trauma and major surgery, which could be characterized by functional disturbances and quantity decline in lymphocytes [Therefore, we tested the h... | PMC10184475 |
Methods and materials | PMC10184475 | |||
Ethics and registration | PMC10184475 | |||
Ethical approval | for this study (ethics: KY-20211130002-02) was provided by the Ethics Committee of the affiliated Lianyungang Hospital of Xuzhou Medical University, Lianyungang, China on 29 January 2022. The trial was registered in the Chinese Clinical Trial Registry (ChiCTR2200056624) on 09/02/2022 before enrollment. The study protoc... | PMC10184475 |
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