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Results
PMC10085031
Memorizing repetitions
The number of repetitions needed for memorizing the correct information in the LOW and HIGH conditions were 1.32 (
PMC10085031
Outliers
The numbers of omitted outliers were 1.9 (
PMC10085031
Hindsight bias index
An unpaired
PMC10085031
Percentage of hindsight bias index.
The hindsight bias index (%) was defined as 100 (initial responses-recollection values) / (initial responses—correct information), in which initial responses = numerical value of the initial responses, recollection values = numerical value of the recollection values, and correct information = numerical value of the cor...
PMC10085031
Ratio of items showing memory distortions
An unpaired
PMC10085031
The percentage of distorted items.
The distorted items (%) were calculated as the distorted items divided by all the items. “Total,” “Toward” and “Reversed” in the figure indicates the total percentage of distortions, the percentage of distorted items for correct information, and the percentage of distorted items against correct information, respectivel...
PMC10085031
Discussion
non-delayed recollections
The main finding of this study was that the MLOIE (i.e., the number of items to be remembered) affects the magnitude of hindsight bias, which supports the study’s tentative hypothesis. The larger the number of things to remember, the higher the hindsight bias. This finding is a simple but first reported contribution to...
PMC10085031
Conclusions
In conclusion, the present study found that the memory load of information encoded (MLOIE) would amplify the magnitude of hindsight bias. The biased recollection degree was higher in the HIGH than the LOW condition, indicating that the memory load amplifies the magnitude of hindsight bias. This suggests that hindsight ...
PMC10085031
Supporting information
PMC10085031
English Hindsight Bias Test (HBT) items.
(DOCX)Click here for additional data file.
PMC10085031
Japanese Hindsight Bias Test (HBT) items.
(DOCX)Click here for additional data file.
PMC10085031
Original data of the hindsight bias index.
(XLSX)Click here for additional data file.
PMC10085031
References
PMC10085031
Background
HAND INFECTION
Although airway management for paramedics has moved away from endotracheal intubation towards extraglottic airway devices in recent years, in the context of COVID-19, endotracheal intubation has seen a revival. Endotracheal intubation has been recommended again under the assumption that it provides better protection ag...
PMC10184619
Methods
shockable, VF, non-shockable
SECONDARY
In this manikin study paramedics performed advanced cardiac life support with non-shockable (Non-VF) and shockable rhythms (VF) in four settings: ERC guidelines 2021 (control), COVID-19-guidelines using videolaryngoscopic intubation (COVID-19-intubation), laryngeal mask (COVID-19-Laryngeal-Mask) or a modified laryngeal...
PMC10184619
Results
A total of 120 resuscitation scenarios were completed. Compared to control (Non-VF:11 ± 3 s, VF:12 ± 3 s) application of COVID-19-adapted guidelines lead to prolonged no-flow times in all groups (COVID-19-Intubation: Non-VF:17 ± 11 s, VF:19 ± 5 s;p ≤ 0.001; COVID-19-laryngeal-mask: VF:15 ± 5 s,p ≤ 0.01; COVID-19-shower...
PMC10184619
Conclusions
COVID-19-adapted guidelines using videolaryngoscopic intubation lead to a prolongation of no-flow time. The use of a modified laryngeal mask with a shower cap seems to be a suitable compromise combining minimal impact on no-flowtime and reduced aerosol exposure for the involved providers.
PMC10184619
Supplementary Information
The online version contains supplementary material available at 10.1186/s12873-023-00820-y.
PMC10184619
Keywords
Open Access funding enabled and organized by Projekt DEAL.
PMC10184619
Background
infection
INFECTION
Based on experience with SARS-CoV-1, the resuscitation guidelines were adapted to mitigate the risk of infection for the rescuers, while accepting an increase in no-flow time and possibly worse patient outcomes [
PMC10184619
Methods
shockable, OHCA
Ethical approval for this study (Ethical Committee No 2021-414-f-S) was granted on July, 2th 2021 by the Ethical Committee of the University Hospital of Muenster, Muenster, Germany (Chairperson Prof W.E. Berdel). The study was performed at a training center for paramedics in Bielefeld, Germany in August 2021 (‘Studieni...
PMC10184619
Analysis
SAID
STATA version 16 (StataCorp. 2019. Stata Statistical Software: Release 16. College Station, TX: StataCorp LLC.) was used for statistical analyses. The sample size was calculated with a standardized tolerance limit of one standard deviation and no difference, 20 participants were required for a power = 0.8 with a signif...
PMC10184619
Discussion
infection, OHCA, vomiting, SAD
INFECTION, WASTED, COMPLICATIONS
The present paper compares no-flow time and established quality indicators of resuscitation as well as aerosol release using COVID-19 resuscitation guidelines including three different airway management strategies in accordance with the ERC-2021 using a simulation model [Over the last decade, the impact of different ai...
PMC10184619
Limitations
As the influence of the different airway devices on key performance indicators of resuscitation was investigated, the application of the PPE was not part of the study, but obviously leads to a further prolongation of no-flow time [
PMC10184619
Conclusions
The present study shows that the COVID-19-adapted guidelines using ETI led to a prolongation of the no-flow time, which markedly worsened the overall quality of resuscitation. These effects can be attenuated using an SAD. Although the influence of airway management on the outcome of resuscitation and the transmission o...
PMC10184619
Acknowledgements
The authors would like to thank Marvin Deslandes for revision and Helge Myklebust and Laerdal Medical for kindly providing the ’Shower-cap’ concept.
PMC10184619
Authors’ contributions
TB
SSS has been involved in acquisition of data, drafting the manuscript, revising it critically for important intellectual content, gave final approval of the version to be published and gave the Agreement to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any...
PMC10184619
Funding
No funding was obtained for this study.Open Access funding enabled and organized by Projekt DEAL.
PMC10184619
Data Availability
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
PMC10184619
Declarations
PMC10184619
Ethics approval and consent to participate
Ethical approval for this study (Ethical Committee No 2021-414-f-S) was granted on July, 2th 2021 by the Ethical Committee of the University Hospital of Muenster, Muenster, Germany (Chairperson Prof W.E. Berdel). All methods were carried out in accordance with relevant guidelines and regulations in Ethics declaration s...
PMC10184619
Consent for publication
Not applicable.
PMC10184619
Competing interests
The authors declare that they have no competing interests.
PMC10184619
Abbreviations
StatesVentricular Fibrillation, Respiratory Syndrome
Basic Life-SupportCardiopulmonary ResuscitationCorona-Virus-Disease 2019Endotracheal IntubationEuropean Resuscitation Council 2021Extraglottic Airway DevicesFiltering Face Piece 3Laryngeal Mask AirwayOut-of-Hospital Cardiac ArrestPersonal Protective EquipmentSevere Acute Respiratory Syndrome Corona-Virus 1United States...
PMC10184619
References
PMC10184619
Background
prostate cancer, Prostate
DISEASE, PROSTATE CANCER, PROSTATE
Isolated local failure (ILF) can occur in patients who initially receive definitive radiation therapy for prostate cancer. Salvage therapy for ILF includes high dose rate (HDR) brachytherapy. Prostate Specific Membrane Antigen (PSMA) Positron Emission Tomography (PET) can accurately detect ILF and can exclude extrapros...
PMC10116658
Methods
toxicity, prostate cancer
DNA DAMAGE, PROSTATE CANCER, PROSTATE
ROADSTER is a phase I/II randomized, single-institution study. Patients with an ILF of prostate cancer after definitive initial radiation therapy are eligible. The ILF will be confirmed with biopsy, magnetic resonance imaging (MRI) and PSMA PET. Patients will be randomized between HDR brachytherapy in two fractions (a ...
PMC10116658
Discussion
ROADSTER explores a novel salvage therapy for ILF after primary radiotherapy with combined Lutetium-177 PSMA RLT and HDR brachytherapy. The randomized phase I/II design will provide a contemporaneous patient population treated with HDR alone to facilitate assessment of feasibility, tolerability, and biologic effects of...
PMC10116658
Trial registration
NCT05230251 (ClinicalTrials.gov).
PMC10116658
Keywords
PMC10116658
Background
toxicity, prostate, Prostate cancer, prostate cancer deaths, prostate cancer
DISEASE, PROSTATE CANCER RECURRENT, DNA DAMAGE, PROSTATE, PROSTATE CANCER, PROSTATE CANCER
Prostate cancer is a major male health issue, with over 1.4 million new cases of prostate cancer diagnosed and 375,000 new prostate cancer deaths in 2020 worldwide [There are several potentially curative treatment options for patients with ILF, including salvage radical prostatectomy (RP), as well as prostate directed ...
PMC10116658
Methods
PMC10116658
Inclusion and exclusion criteria
prostate cancer, prostate
PROSTATE CANCER, PROSTATE, PROSTATIC DISEASE
Patients with suspected ILF after radiation will be recruited. Patients must have a BCF per Phoenix criteria at least two years after initial prostate cancer treatment, an intra-prostatic lesion with PSMA PET avidity (Standard Uptake Value (SUV) of 3.0 or greater on a diagnostic PSMA PET/CT), and no evidence of extra p...
PMC10116658
Baseline assessment
toxicity, D.L., Prostate Cancer, prostate cancer
PROSTATE CANCER, PROSTATE CANCER
Patients will be required to complete baseline assessments of toxicity by CTCAE v4.0, quality of life (QoL) related to prostate cancer by the Expanded Prostate Cancer Index Composite (EPIC), and baseline bloodwork to assess marrow, renal and hepatic function. Baseline bloodwork and urine samples will be collected as li...
PMC10116658
Treatment
tumor, CTVp
PRIMARY TUMOR, TUMOR, PROSTATE, DISEASE
The trial schema is given in Fig.  ROADSTER trial schemaBrachytherapy will be performed using transrectal ultrasound (TRUS) guidance, under general anesthesia in a dedicated brachytherapy suite, with intraoperative planning. Pre-procedure PSMA PET/MR images will be fused with intra-operative TRUS images using an in-hou...
PMC10116658
Primary and secondary endpoints
toxicity
SECONDARY
ROADSTER is a phase I/II, randomized controlled trial with safety and feasibility as primary outcomes. The planned accrual for the phase I portion of the study will be 12 patients: six patients in cohort 1 and six patients in cohort 2. Safety of each cohort will be declared if no more than one patient in each cohort ex...
PMC10116658
Translational exploratory endpoints
toxicity, tumor, prostate cancer, prostate
TUMOR, DNA DAMAGE, PROSTATE, BLOOD, PROSTATE CANCER
At the time of the second HDR treatment for cohort 1 and the HDR treatment for cohort 2, patients will receive a research prostate biopsy via a transperineal approach under ultrasound guidance. Targeted biopsies of PSMA PET/MR defined lesions will be obtained along with systematic biopsies of the whole gland. These tis...
PMC10116658
Discussion
tumor, CRPC, occult extra-prostatic disease, toxicity, occult metastatic disease, prostate, prostate HDR, prostate cancer
TUMOR, DISEASE, RECURRENT DISEASE, METASTATIC DISEASE, PROSTATE, SECONDARY, PROSTATE CANCER, CANCER RELAPSE
As a primary outcome, the ROASDTER trial investigates the feasibility and safety of a novel salvage strategy that combines Lu-177 PSMA RLT with HDR brachytherapy in patients with proven radiorecurrent ILF with no signs of metastatic disease. By adding Lu-177 PSMA RLT as a systemic therapy early in the course of cancer ...
PMC10116658
Acknowledgements
The authors acknowledge the patients who enrolled in this trial and supported this research.
PMC10116658
Authors’ contributions
LCM
AD – Wrote initial draft of manuscript and approved finalized manuscript. GB – Trial concept development and protocol writing. Edited initial draft of manuscript and approved finalized manuscript. LCM – Trial concept development and protocol writing. Edited initial draft of manuscript and approved finalized manuscript....
PMC10116658
Funding
This trial was funded with support from the London Health Sciences Foundation. The London Health Sciences Foundation did not contribute to the study design; the collection, management, analysis and interpretation of data; writing of the report; or the decision to submit the report for publication.
PMC10116658
Data Availability
The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
PMC10116658
Declarations
PMC10116658
Competing interests
CCSRI, CRS, MM
LCM
AD – none. GB – Industry Advisory Boards and Speaking – Tolmar, Trelstar, and Advanced Accelerator Applications; Industry Research – Siemens, and Invicro; Leadership – OICR Clinical Lead Clinical Translation Program, and OH-CCO PET Steering Committee; Research Funding – OICR, CIHR, and CCSRI. LCM – none. DL – none. MM ...
PMC10116658
Ethics approval and consent to participate
This study has been approved by the Western University Health Sciences Research Ethics Board (Project ID: 120132) and will be conducted in accordance with the principles of the Declaration of Helsinki. Western University, located in London, Ontario, Canada, is the University partner of the London Health Sciences Centre...
PMC10116658
Consent to publish
Patients will give their consent voluntarily to have the results published.
PMC10116658
References
PMC10116658
Subject terms
VF, glaucoma, Retinal nerve fiber layer
GLAUCOMA SUSPECT, GLAUCOMA
This study compared between TEMPO, a new binocular perimeter, with the Humphrey Field Analyzer (HFA). Patients were tested with both TEMPO 24–2 Ambient Interactive Zippy Estimated by Sequential Testing (AIZE)-Rapid and HFA 24–2 Swedish Interactive Threshold Algorithm (SITA)-Fast in a randomized sequence on the same day...
PMC10692178
Introduction
fatigue, optic neuropathy, Glaucoma
OPTIC NEUROPATHY, GLAUCOMA
Glaucoma is an optic neuropathy characterized by the gradual loss of retinal ganglion cells and their axons, which can lead to vision lossWe hypothesized that this new technology could reduce testing duration and patient fatigue, minimize variability in test results, and improve the correlation between structural and f...
PMC10692178
Discussion
VF, strabismus, nystagmus, glaucoma, TEMPO
DISEASE, STRABISMUS, NYSTAGMUS, DYSFUNCTION, GLAUCOMA, ANISOMETROPIA
In this study, we prospectively performed VF testing with both TEMPO AIZE-Rapid and HFA Swedish Interactive Threshold Algorithm (SITA)-Fast in a randomized order and identified a stronger structure–function relationship and better reliability indices with TEMPO compared to HFA. TEMPO reduced measurement time by approxi...
PMC10692178
Methods
PMC10692178
Participants
Glaucomatous optic neuropathy, glaucomatous VF damage, glaucomatous optic neuropathy, glaucomatous defect, atrophy, glaucoma, Glaucoma
GLAUCOMATOUS OPTIC NEUROPATHY, INTRAOCULAR PRESSURE, PRIMARY ANGLE CLOSURE GLAUCOMA, GLAUCOMA SUSPECT, PRIMARY OPEN-ANGLE GLAUCOMA, ATROPHY, SECONDARY GLAUCOMA, GLAUCOMA, AGE-RELATED MACULAR DEGENERATION, EYE, GLAUCOMA, GLAUCOMA SUSPECT
Participants were recruited from patients at the Shiley Eye Institute, University of California, San Diego. The research protocol followed the tenets of the Declaration of Helsinki and was approved by the University of California, San Diego Institutional Review Board. All study participants provided written informed co...
PMC10692178
Visual field testing
TEMPO (CREWT Medical Systems, Tokyo, Japan) is the commercial name of the product. It is distinct from the portable head-mounted perimeter device known as imoFor the current study, all patients underwent HFA 24–2 SITA-Fast and TEMPO 24–2 AIZE-Rapid on the same day in a randomized order using Goldmann size III (0.431° v...
PMC10692178
Structure–function relationship
VF, RA, retinal nerve fiber
RNFL was measured using Cirrus spectrum-domain OCT (Carl Zeiss Meditec, Inc, Dublin, CA) Optic Disc Cube 200 × 200 protocol scans. A 3.46 mm diameter circle was automatically placed around the optic disc, providing RNFL thickness globally and in superior, inferior, temporal, and nasal sectors. Coefficient of determinat...
PMC10692178
Statistical analysis
VF
Patient and eye characteristics were reported as mean (95% CI) for continuous data and count (percentage) for categorical data. MD, PSD, foveal threshold (FT), and VFI were compared using mixed-effects model between the two perimeters. Reliability indices were illustrated in a kernel density estimate plot to compare th...
PMC10692178
Supplementary Information
The online version contains supplementary material available at 10.1038/s41598-023-48105-5.
PMC10692178
Acknowledgements
DISEASE, EYE
T.N.: C: Topcon (consultant). R.N.W.: Abbvie, Alcon, Allergan, Amydis, Editas, Eyenovia, Iantrek, IOPtic, Implandata, iSTAR Medical, Nicox, Santen, Tenpoint, and Topcon (consultant); National Eye Institute, National Institute for Minority Health and Health Disparities, Centervue (research support); Toromedes, Carl Zeis...
PMC10692178
Author contributions
Designed and conducted the study: T.N., R.N.W. and S.M. Data collection: T.N. and J.A., Data analysis: T.N. Interpretation: T.N., R.N.W. and S.M. Writing: T.N. and R.N.W. Critical revision: All authors. Manuscript approval: All authors.
PMC10692178
Funding
EYE
Supported by R01EY029058 and R01EY034148 (RNW) from National Institutes of Health/National Eye Institute Grants.
PMC10692178
Data availability
The datasets used and/or analysed during the current study available from the corresponding author on reasonable request.
PMC10692178
Competing interests
The authors declare no competing interests.
PMC10692178
References
PMC10692178
Purpose
MPE
Communicated by Fabio fischetti.To compare fixed transverse textile electrodes (TTE) knitted into a sock versus motor point placed standard gel electrodes (MPE) on peak venous velocity (PVV) and discomfort, during calf neuromuscular electrical stimulation (calf-NMES).
PMC10460736
Methods
NRS, MPE
Ten healthy participants received calf-NMES with increasing intensity until plantar flexion (measurement level I = ML I), and an additional mean 4 mA intensity (ML II), utilizing TTE and MPE. PVV was measured with Doppler ultrasound in the popliteal and femoral veins at baseline, ML I and II. Discomfort was assessed wi...
PMC10460736
Results
MPE
TTE and MPE both induced significant increases in PVV from baseline to ML I and significantly higher increases to ML II, in both the popliteal and femoral veins (all
PMC10460736
Conclusion
MPE
TTE integrated in a sock produces intensity-dependent increases of popliteal and femoral hemodynamics comparable to MPE, but results in more discomfort at plantar flexion due to higher current required. TTE exhibits in the popliteal vein higher increases of PVV compared to MPE.
PMC10460736
Trial registration
Trial_ID: ISRCTN49260430. Date: 11/01/2022. Retrospectively registered.
PMC10460736
Keywords
Open access funding provided by Karolinska Institute.
PMC10460736
Introduction
fits, MPE, venous stasis, VTE, Venous stasis, venous thromboembolism
SECONDARY, VENOUS STASIS, DEEP VEIN THROMBOSIS (DVT), VENOUS STASIS
Venous stasis is one of the major causes of venous thromboembolism (VTE), which often starts as a deep vein thrombosis (DVT). VTE-prevention targeting venous stasis of the calf include passive compression socks and active mechanical interventions, such as intermittent pneumatic compression and neuromuscular electrical ...
PMC10460736
Materials and methods
PMC10460736
Electrode-setups
MP, MPE
In this study, two different electrode setups for applying NMES to the calf were tested and compared regarding various outcomes. The electrode setups differed regarding electrode- type, and placement and were compared to investigate if textile electrodes knitted in fixed transverse positions in a sock, would yield a no...
PMC10460736
Motor point scan
MP
The best MPs were found by scanning one half of the calf at a time (medial/lateral), using the NMES device’s 3 Hz sinusoidal wave motor scan program (Chattanooga Physio constant current generator, DJO Nordic, Malmoe, Sweden). Prior to the MP scan, the side of the calf about to be scanned was covered by a thin layer of ...
PMC10460736
NMES-Settings
MP
For both electrode setups, NMES was applied using the same NMES device as for the MP scan. The NMES stimulation used a biphasic symmetric square wave, meaning that the electrodes continuously were switching polarity so that they alternately, and for equally long durations, served as either anode or cathode. Thus, there...
PMC10460736
NMES Measurement Level I & II
The NMES-device display the current used for the selected stimulation in NMES-levels ranging from 0 to 999, which in a non-linear pulse duration dependent fashion correlate to current amplitudes ranging from 0 to 120 mA. The formula to calculate this correlation may be obtained from the manufacturer (DJO Nordic, Malmoe...
PMC10460736
Hemodynamic measurements
CONTRACTION
Using a Philips CX50 (2013) Doppler ultrasound machine (Philips Medical Systems, Andover, MA, USA), the widest accessible part of the popliteal and femoral veins was located and visualized in a longitudinal plane before beginning the hemodynamic measurements. The diameters of the veins were calculated at baseline. The ...
PMC10460736
Discomfort
NRS
For each stepwise increase in NMES-levels when testing the two electrode setups, participants were asked to fill in a form to rate their discomfort on a numerical rating scale (NRS) 0–10, where 0 was described to the subject as no discomfort and 10 as the worst imaginable discomfort (Hawker et al.
PMC10460736
Statistical analysis
NRS
The sample size was determined prior to the start of the experiment based on a pilot study with a difference in PPV between ML I to ML II of 20 cm/s and sigma of 20, with the significance level set at The data were analyzed using SPSS version 27 (IBM Corp. Released 2016. IBM SPSS Statistics for Windows, Armonk, NY: IBM...
PMC10460736
Results
PMC10460736
Current intensities in mA for calf-NMES
MPE
The median (IQR) current intensity required to reach ML I, was significantly lower when using MPE, 16 (7.4) mA, as compared to TTE, 26 (14) mA (Current intensity (mA) required to reach ML I displayed for the TTE and MPE setups. In the boxplot, the length of the box represents IQR, and error bars represent min–max. The ...
PMC10460736
Hemodynamics of calf-NMES
PMC10460736
Hemodynamics in the popliteal vein
MPE
The median (IQR) baseline PVV in the popliteal vein was 14.3 (5.4) cm/s. There were significant increases of PVV from baseline to ML I when using both TTE, 29.1 (47.3) cm/s (Hemodynamics in the popliteal vein. Percentual increase of PVV from baseline to ML I and ML II displayed for the TTE and MPE setups. In the boxplo...
PMC10460736
Hemodynamics in the femoral vein
MPE
The median (IQR) baseline PVV in the femoral vein was 14.2 (3.9) cm/s. PVV exhibited statistically significant increases from baseline to ML I when using both TTE, 21.6 (8.8) cm/s (Hemodynamics in the femoral vein. Percentual increase of PVV from baseline to ML I and ML II for the TTE and MPE setups. In the boxplot, th...
PMC10460736
Discomfort of calf NMES
NRS, MPE
Using MPE resulted in a statistically significantly lower median NRS (range), 1 (0–3), compared to the use of TTE, NRS 2 (0–7), at ML I (Discomfort of calf NMES. NRS score for the TTE and MPE setups at ML I and ML II. In the boxplot, the length of the box represents IQR, and error bars represent min–max and in case of ...
PMC10460736
Associations of participant characteristics with outcome
MPE
Female participants, as compared to male participants, required significantly higher current intensity (mA) to produce a plantar flexion, both with TTE and MPE (
PMC10460736
Discussion
Uhl, pelvic fractures, MPE, venous stasis, DVT, VTE, MP
BLOOD CLOTS, EVANS, VENOUS STASIS, DVT
The main finding of this study was that the PVV in both the popliteal and the femoral veins exhibited a dose–response relationship to the current intensity administered to the calf, for both the TTE and the MPE setups. The TTE setup required higher current intensity than the MPE setup to induce a plantar flexion (ML I)...
PMC10460736
Conclusion
NMES of the calf increases PVV in an intensity-dependent and clinically relevant manner in both the popliteal and femoral veins using both a TTE
PMC10460736
Acknowledgements
Not applicable.
PMC10460736
Author contributions
PA, JF and RJ wrote the application for the approved ethical permit. RJ, PA, JF, LG, N-KP and CS performed material preparation and created the study protocol. CS and RJ collected and prepared the data for statistical analysis. CS performed the statistical analysis. CS, RJ, JF, and PA wrote the manuscript. All authors ...
PMC10460736
Funding
Open access funding provided by Karolinska Institute. This work was supported by the strategic innovation programs Swelife and Medtech4Health, which are jointly arranged and funded by Sweden´s Innovation Agency (Vinnova), Grant no: 2019-05479 Formas and Energimyndigheten.
PMC10460736