title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Patient consent for publication | Not applicable. | PMC10447378 | ||
Ethics approval | This study involves human participants and was approved by South Central Oxford REC B (Ref: 118784, Ethics number: 12/SC/0713). Participants gave informed consent to participate in the study before taking part. | PMC10447378 | ||
References | PMC10447378 | |||
Methods | apnea hypopnea, CRAE, hypertension/hypercholesterolemia, CRVE, SDB | REGRESSION | Patients for SDB assessment were recruited (Main Group, n = 264, age: 58.5 ± 8.9 yrs [mean ± SD]; males: 141) for in-laboratory polysomnography (standard metrics, eg apnea hypopnea index, AHI) and retinal photographs (evening and morning). A more severe SDB sub-group (n = 85) entered a 12-month cardiovascular risk fact... | PMC9831323 |
Conclusion | cerebro-vascular disease, CRAE, OSA, CRVE, SDB | No major SDB associations with CRAE or CRVE were identified, although the RFM/CPAP intervention reduced evening CRVE for severe OSA patients. Implications for cerebro-vascular disease risk remain uncertain. | PMC9831323 | |
Trial registration | The protocol was registered with the Australian New Zealand Clinical Trials Registry (Trial Id: | PMC9831323 | ||
Data Availability | All relevant data are within the article and its | PMC9831323 | ||
Introduction | cardiovascular disease, CRAE, stroke, cardio- and cerebro-vascular diseases, OSA, hypertension, CRVE, diabetes | CARDIOVASCULAR DISEASE, OBSTRUCTIVE SLEEP APNEA, STROKE, CORONARY HEART DISEASE, HYPERTENSION, DIABETES | A number of studies have suggested that obstructive sleep apnea (OSA) increases risk for cardio- and cerebro-vascular diseases, including hypertension, coronary heart disease and stroke [There is one microvascular bed that can be readily and non-invasively accessed in clinical settings by using digital photography to p... | PMC9831323 |
Methods | PMC9831323 | |||
Registration | This study was not initially registered as a clinical trial before enrolment of participants because it was originally conceived as an observational study. The authors confirm that all onging and related trials for this intervention are registered. The protocol was registered with the Australian New Zealand Clinical Tr... | PMC9831323 | ||
Study participants | Respiratory Disturbance, diabetes | DIABETES | We recruited 335 adults all over the age of 35 years, referred to a sleep clinic at Westmead Hospital between 2Participants were screened for diabetes and 40 were subsequently excluded on the basis of either a history of diabetes or a fasting blood sugar level ≥ 6.9 mmol/L, while 31 other participants either withdrew o... | PMC9831323 |
Study flow diagram. | respiratory disturbance, SDB | RECRUITMENT, SLEEP DISORDERED BREATHING | Study flow diagram showing movement of participants and data through the recruitment and screening phases, the “Main Group” and “RFM/CPAP sub-group” Cross-Sectional Analyses and the Intervention Study. SDB = sleep disordered breathing; BSL = blood sugar level; PSG = polysomnography; CPAP = continuous positive airway pr... | PMC9831323 |
Polysomnography | PSG studies were recorded using Compumedics Profusion PSG4 software (Compumedics Limited; Abbotsford, Victoria, Australia) and scored according to standard guidelines [ | PMC9831323 | ||
Retinal photography | CRVE, CRAE | DILATION | Retinal images were obtained from each eye with a non-mydriatic digital camera (Canon CR2-Plus, Canon, Japan) before (evening-pm) and after (morning-am) sleep, and after pupil dilation (one drop of 1% Tropicamide) in most subjects (n = 239 [pm] and n = 194 [am]). A retinal photograph centred on the optic disc was taken... | PMC9831323 |
RFM/CPAP intervention (RFM/CPAP sub-group only) | hypertension, hypercholesterolaemia | MINOR, HYPERTENSION, RECRUITMENT, HYPERCHOLESTEROLAEMIA | After recruitment to the intervention study, participants with hypertension or hypercholesterolaemia were prescribed appropriate medication and undertook a 1-month run-in stabilisation period. Participants underwent a second PSG at Westmead Hospital Sleep Laboratory to determine the appropriate CPAP treatment pressure ... | PMC9831323 |
Data analysis | ±, CRVE, CRAE, SDB | REGRESSION | All statistical analyses were performed using SPSS version 24.0 (IBM SPSS Statistics for Windows, Version 24.0. Armonk, NY: IBM Corp.).Main and RFM/CPAP Sub-Group data were expressed as mean (± standard deviation) or median (interquartile range) for continuous variables, and frequency and percentage for categorical var... | PMC9831323 |
Results | PMC9831323 | |||
Cross-sectional study–main group | CRVE, CRAE, SDB | This section describes results for the primary study analyses which focused on determining cross-sectional associations for non-SDB (Base Models) and SDB severity metrics (SDB Variable Models) with measured evening CRAE, CRVE, and overnight change in CRAE and CRVE, in Main Group participants (n = 264). | PMC9831323 | |
Main group demographics and sleep disordered breathing status. | CRAE, Respiratory Disturbance, Apnea-Hypopnea, Desaturation, SDB | Demographics and SDB status of the Main Group at baseline, presented as mean ± SD, median (IQR) frequency, or n (%), where appropriate, plus range.SD = Standard deviation; IQ range = 25–75 interquartile range; BMI = Body Mass Index; WHR = waist/hip ratio; BP = blood pressure; MAP = Mean Arterial Pressure; HDL = high-de... | PMC9831323 | |
Main group data for evening, morning and overnight change in CRAE and CRVE and AVR grouped by AHI category. | apnoea-hypopnea | Data are mean ± SD.CRAE = Central retinal arteriolar equivalent; CRVE = central retinal venular equivalent; AVR = arterio-venule-ratio; AHI = apnoea-hypopnea index; Delta = overnight change. | PMC9831323 | |
Cross-sectional study—RFM/CPAP sub-group | CRVE, CRAE, SDB | This section describes comparison of descriptive data for the RFM/CPAP Sub-Group (n = 85) versus those Main Group partcipants who were not recruited into the intervention study (n = 179), together with cross-sectional associations for non-SDB (Base Models) and SDB severity metrics (SDB Variable Models) with measured ev... | PMC9831323 | |
Descriptive data and univariate analysis-RFM/CPAP sub-group | hypertension, CRVE, CRAE, SDB | HYPERTENSION | RFM/CPAP Sub-group participants differed from the Main Group participants who were not recuited into the sub-group (all p < 0.04) for gender composition, most measures of body size, hypertension history, overall cardiovascular risk, and all SDB variables. Thus, the applied selection criteria enriched the RFM/CPAP-Sub G... | PMC9831323 |
RFM/CPAP sub-group intervention study | OSA, cardiovascular disease, CRAE, CRVE | HYPERCHOLESTEROLEMIA, HYPERTENSION, CARDIOVASCULAR DISEASE | This section describes results for the 12 month RFM/CPAP interventional study (n = 66) which aimed to evaluate whether stabilising known cardiovascular disease risk factors (hypertension, hypercholesterolemia), while concurrently treating OSA with continuous positive airway pressure (CPAP), would result in alterations ... | PMC9831323 |
Discussion | morning CRVE, CRAE, retinal microvascular, CRVE, SDB | RETINAL VASCULAR, OTHER CARDIOVASCULAR DISEASE, RETINA | The primary focus of the present study was to test for relationships, in a non-diabetic sleep-clinic patient cohort, between polysomnography determined SDB severity and retinal micro-vasculature morphology. Overall no such relationships were detected, but when a subgroup enriched with more severe levels of SDB was exam... | PMC9831323 |
Study cohort characteristics | diabetes, cardio-vascular disease, SDB | DIABETES | In interpreting our results it is important to understand the characteristics of the study cohort. This was not a randomised community-recruited population-based study. We targeted a specific clinic group (i.e. patients referred to a sleep clinic for assessment of SDB) and then screened for and eliminated diabetes as a... | PMC9831323 |
Evening CRAE | SDB RFM/CPAP, hypoxia, CRAE, SDB | HYPOXIA, EYE | Group mean values for evening CRAE in our Main Group were ~12% smaller than reported for the younger Inter99 Eye study non-sleep cohort [In our multivariate Base Models, Main Group evening CRAE values were predicted by a combination of “fixed at the time of study” individual characteristics (age, ethnicity, height, smo... | PMC9831323 |
Evening CRVE | hypertension, CRVE, CRAE, SDB | HYPERTENSION, EYE | Group mean values for evening CRVE in our Main Group were ~15% smaller than reported for the younger Inter99 Eye study community cohort [In multivariate Base Models, Main Group evening CRVE values were predicted by a combination of “fixed at the time of study” individual characteristics (ethnicity, smoking history, hyp... | PMC9831323 |
RFM/CPAP intervention study | CRAE, stroke, OSA, CRVE, SDB | STROKE | When a sub-group with a wide range of SDB severity were individually stabilised on medical therapy, monitored and given CPAP therapy over a 12 month period, there was no change in group mean evening CRAE or CRVE values or the overnight change in CRAE or CRVE. However, evening CRVE values tended to decrease over the CPA... | PMC9831323 |
Study limitations | retinal microvascular anatomy, failure, diabetes, cardio-vascular disease, hypertension, SDB | HYPERTENSION, HYPERCHOLESTEROLAEMIA, DIABETES | The study has a number of strengths and limitations. Firstly, it is essentially descriptive and exploratory in nature, consequently, its results should be interpreted accordingly. In addition, given the number of relationships explored, p-values provided should be regarded as only a guide to any potential relationships... | PMC9831323 |
Conclusion | cardiovascular disease, CRVE, CRAE, SDB | MINOR, CARDIOVASCULAR DISEASE | In this study of non-diabetic patients presenting to a sleep clinic for investigation of SDB, total variance in retinal vessel size was partially explained by a combination of anthropometric characteristics and known predictors, with measures of SDB providing very little to no contribution. In a more severely affected ... | PMC9831323 |
Supporting information | (PDF)Click here for additional data file. | PMC9831323 | ||
Univariate correlations- main group (n = 264). | Spearman’s Rank Correlation Coefficients for associations between anthropometric/demographic characteristics, Framingham Risk, blood test results, and SDB variables versus retinal vessel diameters and their overnight change—Main Group.(DOCX)Click here for additional data file. | PMC9831323 | ||
RFM/CPAP sub-group versus main group (minus RFM/CPAP sub-group) participant characteristics. | Continuous A) and categorical B) data comparisons for RFM/CPAP Sub-Group participants (n = 85) versus Main Group minus CPAP Sub-Group participants (n = 179).(DOCX)Click here for additional data file. | PMC9831323 | ||
Multiple linear regression models for evening retinal vessel diameters using non -SDB variables (base models)—main group (n = 264). | CRVE, CRAE, SDB | Base Models showing non- SDB variable predictors for evening CRAE (A) and evening CRVE (B) for the Main Group.(DOCX)Click here for additional data file. | PMC9831323 | |
Multiple linear regression models for evening retinal vessel diameters using SDB variables (SDB models)—main group (n = 264). | CRVE, CRAE, SDB | Results of adding each SDB variable individually to the Base Model for evening CRAE (A) and evening CRVE (B) in the Main Group.(DOCX)Click here for additional data file. | PMC9831323 | |
Multiple linear regression models for evening CRAE using SDB variables (SDB models)- RFM/CPAP sub-group (n = 85). | CRAE | Results of adding LnAHI+1 and AHI Category into the Base Model for CRAE in the RFM/CPAP Sub-Group.(DOCX)Click here for additional data file. | PMC9831323 | |
Compressed file archive–SPSS data/anonymysed data. | (ZIP)Click here for additional data file. | PMC9831323 | ||
Compressed file archive–SPSS syntax. | (ZIP)Click here for additional data file. | PMC9831323 | ||
Compressed file archive: Anonymised raw data/other. | Tracey Burns | MITCHELL | (ZIP)Click here for additional data file.(ZIP)Click here for additional data file.(PDF)Click here for additional data file.The authors thank ResMed (Australia) for providing CPAP machines; Jie-Jin Wang for advice and discussion; Karen Byth and Jannah Baker for assistance with statistical analysis; Tracey Burns, Manisha... | PMC9831323 |
References | PMC9831323 | |||
Background | occlusion of the aorta | HAEMORRHAGIC SHOCK | Resuscitative endovascular balloon occlusion of the aorta (REBOA) is increasingly used. The recently published UK-REBOA trial aimed to investigate patients suffering haemorrhagic shock and randomized to standard care alone or REBOA as adjunct to standard care and concludes that REBOA may increase the mortality. | PMC10619299 |
Main body | In this commentary we try to balance the discussion on use of REBOA and address limitations in the UK-REBOA trial that may have influenced the outcome of the study. | PMC10619299 | ||
Conclusion | The situation is complex, and the patients are in extremis. In summary, we do not think this is the end of balloons. | PMC10619299 | ||
Keywords | PMC10619299 | |||
Background | occlusion of the aorta | HAEMORRHAGIC SHOCK | Resuscitative endovascular balloon occlusion of the aorta (REBOA) is increasingly used, with haemorrhagic shock as the most common indication [Regardless, the recent publication of the UK-REBOA trial [ | PMC10619299 |
Main text | aortic occlusion, bleeding, head injury, Traumatic brain injury, cardiac arrest, haemorrhage, trauma | AORTIC OCCLUSION, BLEEDING, STILL, CARDIAC ARREST, HAEMORRHAGE, HAEMORRHAGIC SHOCK | The UK-REBOA trial aimed to investigate patients suffering haemorrhagic shock and randomized to standard care alone (SC) or REBOA as adjunct to standard care. The study (and subsequently commentators on social media platforms such as Twitter/X) concludes that REBOA may increase the mortality [The study leaves numerous ... | PMC10619299 |
Conclusions | non-traumatic haemorrhage | Obviously, these patients are in extremis and the situation is complex. With all the abovementioned limitations, we believe that it is wrong to solely credit (or discredit) REBOA for the results. To successfully salvage the critically injured patient, we need to improve the sum of marginal gains. Short prehospital time... | PMC10619299 | |
Acknowledgements | Not applicable. | PMC10619299 | ||
Author contributions | MR | JRB drafted the manuscript. MR reviewed the manuscript. Both authors read and approved the final manuscript. | PMC10619299 | |
Funding | Not applicable. | PMC10619299 | ||
Availability of data and materials | Not applicable. | PMC10619299 | ||
Declarations | PMC10619299 | |||
Ethics approval and consent to participate | Not applicable. | PMC10619299 | ||
Consent for publication | Not applicable. | PMC10619299 | ||
Competing interests | CARDIAC ARREST | The authors declare that they have no financial competing interest. JRB and MR are both involved in REBOA research in cardiac arrest. Both authors are partially employed in the Norwegian Air Ambulance Foundation for research purposes. | PMC10619299 | |
References | PMC10619299 | |||
Background | Advancing the health of adolescents, particularly their sexual and reproductive health, including HIV prevention and care, is a development imperative. A critical part for improving their wellbeing and economic development is the social status accorded to adolescent girls and young women (AGYW). However, AGYW in many c... | PMC9933327 | ||
Methods | The aim was to reduce EUP and improve SRH outcomes among AGYW in Zambia through provision of CSE linked to receptive SRH services. A 3-Arm randomized control study collected cross-sectional data at baseline, midline and Endline. Schools where CSE was being routinely provided were randomized into a non-intervention arm ... | PMC9933327 | ||
Results | Following 3 years of intervention exposure (CSE-Health Facility linkages), findings showed a significant decline of in-school pregnancies amongst AGYW in both intervention arms, with arm two exhibiting a more significant decline, having recorded only 0.74% pregnancies at endline ( | PMC9933327 | ||
Conclusion | Linking provision of CSE with accessible SRH services that are receptive to needs of adolescents and young people reduces EUP, which provides the opportunity for higher retention in school for adolescent girls. | PMC9933327 | ||
Plain English summary | Among Zambia’s key health and development challenges, are high rates of EUP, and disproportionately higher HIV rates among AGYW. Pregnancy among girls in school poses a challenge. CSE programmes are part of available armamentarium to improve knowledge on the risks. Poor SRH places a heavy strain on health systems and u... | PMC9933327 | ||
Keywords | PMC9933327 | |||
Background | CSE | SECONDARY, SEXUALLY TRANSMITTED INFECTIONS | School attrition attributed to early and unintended pregnancy (EUP) exposes adolescent girls and young women (AGYW) to various social and financial hardships, negatively impacting access to resources and, thus, perpetuating gender-based inequities. School dropout is associated with poorer sexual and reproductive health... | PMC9933327 |
Methods | PMC9933327 | |||
Setting and study sample | SECONDARY | The study was implemented in selected schools and health facilities in Solwezi and Mufumbwe Districts (North-Western Province) of Zambia from 2017 to 2020. These two districts were selected because of high background adolescent pregnancy rates [A cross-sectional baseline assessment was conducted from August to November... | PMC9933327 | |
Measures | SECONDARY | The present paper is concerned with in-school EUP as the outcome of interest. In addition, background characteristics of the study population were collected annually at each questionnaire round. Data was collected using preloaded study instruments on tablets using SurveyCTO software. A conceptual framework (see Fig. Pr... | PMC9933327 | |
Sample size | sexual behaviors | The overall sample size was calculated based on the number of adolescents required to derive differences, if any, in knowledge and behavioural variables that meet the criteria in each school and each selected grade, and thus more applicable in later analysis, while noting adequacy for lower-level variables, such as pre... | PMC9933327 | |
Data management analysis | REGRESSION | Collected data (entered using SurveyCTO) was transferred to Excel for preliminary cleaning, then transferred to Stata/IC 15.1 for further management and analysis. Bivariate logistic regression was implemented to examine whether socio-demographic characteristics in the study population differed significantly by study ar... | PMC9933327 | |
Results | PMC9933327 | |||
Background of sample socio-demographic characteristics | SECONDARY | Descriptive sample characteristics at endline (R3-PI) of 986 participating AGYW are presented in Table Descriptive sample characteristics at endline (R3-PI)Of those in secondary school, a greater proportion (21.1%) were in Grade 8 and Grade 9 (18.8%). There were no significant differences between the arms at endline, r... | PMC9933327 | |
Pregnancies in school | By study endline in 2020 (R3-PI), there were noteworthy reductions in the numbers of adolescent pregnancies following exposure to the CSE linkage program, with marked reductions documented in Arms 2 and 3 (see Fig. Cumulative number of school-level pregnancies, by year and study armA test of proportion was conducted to... | PMC9933327 | ||
Discussion | CSE, death | COMPLICATIONS | Findings in this paper suggest a significant decline in early and unintended pregnancies within schools featuring integrated CSE linked to SRH information and services, particularly when efforts are made to bring information on SRH services, to schools and linking CSE with health facilities that are sensitized to be mo... | PMC9933327 |
Conclusion | LATE PREGNANCIES | Considering that the odds of exposure to both in-school CSE and accessible receptive health facility-based SRH services, significantly increased for students in intervention arms 2 and 3, and pregnancies significantly declined, it appears that at least both of those additional interventions are beneficial and should be... | PMC9933327 | |
Acknowledgements | We are grateful to all the schools that participated, Ministries of General Education and Health, at Head Quarters; Provincial and District levels staff whose support was invaluable, all the schools’ Parent Teacher Associations (PTAs) which endorsed the study, and the implementing partner we worked with, Young Women Ch... | PMC9933327 | ||
Authors’ contributions | MTM: study conceptualization, design, training, generation and analysis of data and paper writing; KK, N-CM, SI, ESN: training, generation, management and analysis of data and paper writing; JGR, RM, NO, CP, NC: data analysis and scientific writing; CK: training, drafting SOPs, and data generation. The author(s) read a... | PMC9933327 | ||
Funding | 2016–2021 | This work was funded by the United Nations Education, Social and Cultural Organization (UNESCO), under Contracts 4500427570 and 4500403122-A1, and United Nations Population Fund (UNFPA), under the 2016–2021 Implementing Partners Agreement. | PMC9933327 | |
Availability of data and materials | The datasets generated and /or analysed specific to the current reported study are available on reasonable request to Population Council, Zambia, Data Manager Mr. Kondwani Kasonda kkasonda@popcouncil.org. | PMC9933327 | ||
Declarations | PMC9933327 | |||
Ethics approval and consent to participate | This study received ethical review and independent ethical approvals from Population Council’s Institutional Review Board (IRB), 1 Dag Hammarskjold, New York, NY 10017, USA; as well as the Zambia National IRB ERES CONVERRGE, Joseph Mwilwa Road, Lusaka 10100. We declare that all study methods were carried out in accorda... | PMC9933327 | ||
Consent for publication | Not Applicable, as that is not a prerequisite. | PMC9933327 | ||
Competing interests | The authors of this manuscript have no conflict of interest to declare. | PMC9933327 | ||
References | PMC9933327 | |||
Background | CMDs, stress-related disorders | DISORDERS | The number of people with common mental disorders (CMDs), especially stress-related disorders, has increased in several countries, including Sweden, during the past decade. Patients seeking care for long-term stress report severe symptoms. Although person-centred care (PCC) has shown several benefits, studies evaluatin... | PMC10585814 |
Objective | The aim of this study was to compare levels of self-reported symptoms of burnout between a control group receiving treatment as usual (TAU) and an intervention group receiving TAU with the addition of a person-centred eHealth intervention, in patients on sick leave for CMDs. | PMC10585814 | ||
Methods | SECONDARY | This study reports analysis of a secondary outcome measure from a randomized controlled trial. Patients (n = 209) on sick leave for CMDs were recruited from nine primary health care centres and allocated to either a control group (n = 107) or an intervention group (n = 102). The intervention consisted of phone support ... | PMC10585814 | |
Results | Our findings showed changes in SMBQ scores over time in both the control and the intervention group. There was no significant difference in SMBQ scores between the groups; however, a difference in change over time between the groups was observed. The SMBQ scores decreased significantly more in the intervention group th... | PMC10585814 | ||
Conclusion | This person-centred eHealth intervention for patients on sick leave for CMDs showed a slight initial effect in reducing symptoms of burnout. Taking into account that both groups reported comparable SMBQ scores throughout the study period, the overall effect may be considered limited. | PMC10585814 | ||
Trial registration | : The trial was registered in ClinicalTrials.gov (Identifier NCT03404583). Date of registration: 19/01/2018. | PMC10585814 | ||
Keywords | Open access funding provided by University of Gothenburg. | PMC10585814 | ||
Introduction | CMDs, muscular pain, anxiety, exhaustion disorder, memory impairment, depression, Depression | DISORDERS | Internationally, the term “common mental disorders (CMDs)” often refers to various anxiety and depression disorders [Depression and anxiety are the most common mental health diagnoses among patients in primary care and symptoms of depression and anxiety are strongly related to psychosocial stress [In Sweden, the diagno... | PMC10585814 |
Methods | PMC10585814 | |||
Study design | SECONDARY, DISORDERS | This article reports a secondary outcome analysis of the PROMISE study (“Person-centred eHealth for treatment and rehabilitation of common mental disorders”), which was an open randomized controlled trial (RCT) evaluating the effects of a six-month person-centred eHealth intervention (interactive digital platform and t... | PMC10585814 | |
Setting and participants | anxiety disorder, Anxiety, F32, depression, Depression, adjustment disorders, F33 | DISEASE, DISORDERS | Eligible patients at nine public primary health care centres in western Sweden were screened by designated HCPs and enrolled between February 2018 and June 2020. Patients were considered eligible if they were 18–65 years old, and currently employed or studying (at least part-time) during the last 9 months, had a regist... | PMC10585814 |
Control group | Patients enrolled to the control group received TAU, which for patients with CMDs often takes place in primary care. Initially, they consult a physician to initiate the consultation, treatment, and follow-up on sick leave. Treatment often consists of medication or cognitive behaviour therapy, or both [ | PMC10585814 | ||
Intervention group | The intervention, consisting of PCC delivered via an interactive digital platform (“My Health”), as well as phone support, was provided in addition to TAU. The team of HCPs (n = 5) conducting the intervention represented different disciplines (e.g. nursing, physiotherapy and occupational therapy). All received a half-d... | PMC10585814 | ||
Data collection and outcome measures | Self-reported questionnaire data were gathered by regular mail at baseline and after 3 and 6 months. The level of burnout was assessed using the SMBQ [ | PMC10585814 | ||
Statistical analysis | INTERACTIONS | Descriptive statistics are given in percentages and numbers for categorical variables and means and standard deviation (SD) for continuous variables. Longitudinal associations between the two groups (the intervention and control group) and SMBQ scores were analysed using linear mixed models with random intercept in SPS... | PMC10585814 | |
Discussion | The present study in patients on sick leave for CMDs aimed to compare levels of self-reported symptoms of burnout between a control group receiving TAU and an intervention group receiving a person-centred eHealth intervention in addition to TAU. Our findings showed changes in SMBQ scores over time in both groups. There... | PMC10585814 | ||
Study limitations | SECONDARY | Because this study is a secondary outcome analysis and was not initially used to detect differences in symptoms of burnout, a power calculation was not performed. The response rate on the self-reported questionnaire was relatively high (75%). However, there remains a risk of non-response bias. Another area for improvem... | PMC10585814 | |
Acknowledgements | We want to thank all the participants for sharing their experiences, as well as the professional health care workers Mahboubeh Goudarzi, Eva-Lena Andersson, Paula Johansson Tunås and Emma Vasell for participating. We gratefully acknowledge the contribution of the participating primary centres, their staff, managers, an... | PMC10585814 |
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