title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Funding | This work is supported by National Natural Science Foundation of China (No.31000675), Key R & D projects of Shaanxi Province (2018SF-010), Henan Medical Science and Technology Project (2018020689, LHGJ20190956), and Projects of Xi’an International Medical Center Hospital (2022MS14). | PMC10155412 | ||
Data availability | The datasets used and/or analysed during the current study are available from the | PMC10155412 | ||
Declarations | PMC10155412 | |||
Ethics approval and consent to participate | This study was approved by the medical ethics committee, the second affiliated hospital of Xi’an Jiaotong University (2018024) and written informed consent was approved by each patient’s legal guardian. The study was registered at | PMC10155412 | ||
Consent for publication | Not applicable. | PMC10155412 | ||
Competing interests | The authors declare that they have no competing interests. | PMC10155412 | ||
Abbreviations | Parent-Controlled Intravenous AnalgesiaBody Mass IndexAmerican Society of AnesthesiologistsCase Report Formelectrocardiogrampulse oximetryHeart RateNoninvasive Blood PressureBispectral IndexPost-Anesthesia Care Unitface, legs, activity, cry, consolabilityfunctional activity score | PMC10155412 | ||
References | PMC10155412 | |||
Background | RDS | RESPIRATORY DISTRESS SYNDROME, COMPLICATIONS | The benefit of surfactant replacement therapy for respiratory distress syndrome (RDS) has been demonstrated. However, some surfactants are expensive and usually inaccessible. Consequently, the Iranian Survanta was produced, but its effect on complications and mortality of RDS is unknown. This study aimed to compare the... | PMC10691073 |
Methods | Congenital anomalies, IVH, digestive system anomalies, patent ductus arteriosus, RDS, congenital cyanotic heart diseases, sepsis | PNEUMOTHORAX, INTRAVENTRICULAR HEMORRHAGE, PULMONARY HEMORRHAGE, SEPSIS, COMPLICATIONS, CHROMOSOME ABNORMALITIES | This triple blinded randomized controlled trial study was performed on 128 eligible neonates diagnosed with RDS in Afzalipour hospital in Kerman, Iran. Diagnosis of RDS, gestational age of 28–34 weeks and weight ≥ 1 kg were considered as inclusion criteria. Congenital anomalies such as congenital cyanotic heart disease... | PMC10691073 |
Results | sepsis, IVH | SEPSIS, PULMONARY HEMORRHAGE, PNEUMOTHORAX | Compared with BLES group, the RR estimate among neonates in beraksurf group was 0.89 (0.66–1.20) for PDA, 0.71 (0.23–2.13) for IVH, 0.44 (0.14–1.36) for sepsis, 0.35 (0.13–0.93) for pneumothorax, 0.33 (0.12–0.86) for pulmonary hemorrhage, and 0.55 (0.28–1.05) for mortality. | PMC10691073 |
Conclusions | NEONATAL RESPIRATORY DISTRESS SYNDROME, RESPIRATORY DISTRESS SYNDROME | Despite advances in the use of exogenous surfactants for the treatment of neonatal respiratory distress syndrome; There are still some controversial topics in this field. The results obtained in the present study showed that the two types of surfactant (BERAKSURF and BLES) have similar efficacy for the treatment and sh... | PMC10691073 | |
Supplementary Information | The online version contains supplementary material available at 10.1186/s12887-023-04406-2. | PMC10691073 | ||
Keywords | PMC10691073 | |||
Background | patent ductus arteriosus, RDS | RESPIRATORY DISTRESS SYNDROME | Respiratory distress syndrome (RDS) is a prevalent cause of morbidity and mortality in premature neonates [Normally, surfactant is present in the amniotic fluid from the 28th week of gestation, and its production depends on normal pH, temperature, and perfusion [So far, there are many studies that have evaluated the ef... | PMC10691073 |
Methods | PMC10691073 | |||
Study population | Congenital anomalies, digestive system anomalies, RDS, cyanosis, congenital cyanotic heart diseases | CHROMOSOME ABNORMALITIES | This triple-blind randomized clinical trial study was performed on hospitalized neonates in neonatal intensive care unit (NICU) of Afzalipour hospital (Kerman, Iran) between April 1, 2020 and February 1, 2021. Diagnosis of RDS, gestational age of 28–34 weeks and weight ≥ 1 kg were considered as inclusion criteria. Cong... | PMC10691073 |
Study design | Sample size was calculated at 95% confidence interval (CI) and 80% power based on a similar study [
Flowchart of patients’ enrollment in the two different groups | PMC10691073 | ||
Randomization and allocation concealment | A random number sequence was generated by a person who was not involved in the study, using computer random sequence Stata software version 12. Allocation concealment was performed using numbered, opaque, and sealed envelopes that were opened by the primary researcher at the randomization time. Therefore, all participa... | PMC10691073 | ||
Blinding | The neonates, data collectors, assessors, and analysts were unaware of the type of surfactant in each group and were blinded, making this study triple-blind. | PMC10691073 | ||
Intervention | Two types of surfactants were used for intervention in this study. One group received BLES 135 mg/kg (produced by Blesbiochemical, Canada) and the other group received Survanta (Beraksurf®) 100 mg/kg (produced by Tekzima, Iran). Drug administration in both groups was performed intratracheally for 10 min. The first dose... | PMC10691073 | ||
Outcomes | sepsis, pulmonary hemorrhage, pneumothorax, IVH | PULMONARY HEMORRHAGE, SEPSIS, PNEUMOTHORAX, COMPLICATIONS | The number of days required for the use of invasive mechanical ventilation (ventilator) and non-invasive continuous positive airway pressure (CPAP) was recorded for all neonates. Some complications were evaluated. These complications are PDA (assessed by echocardiography), IVH (assessed by sonography), sepsis (using bl... | PMC10691073 |
Statistical analysis | Data analysis was performed with Stata software version 12 (StataCorp, College Station, TX, USA), and | PMC10691073 | ||
Results | IVH | COMPLICATIONS, INTRAVENTRICULAR HEMORRHAGE | The mean of the gestational age of neonates in Beraksurf and BLES surfactant groups were 31.64 ± 1.69 weeks and 31.03 ± 1.96 weeks and the difference was not significant (
Baseline and Demographic Information* P−value was calculated using chi−2 statistic test at 95% level of confidence interval and independent t−testTh... | PMC10691073 |
Discussion | ®, pneumothorax, IVH, pulmonary hemorrhage, RDS, sepsis, diabetes | PNEUMOTHORAX, PULMONARY HEMORRHAGE, SEPSIS, COMPLICATIONS, DIABETES | The prevalence of RDS is 45% [In this study, we compared a new and cost-effective surfactant produced in Iran with a relatively more expensive and inaccessible surfactant. Based on our results, there were no significant differences between frequencies of gender, type of delivery and diabetes in mothers in BLES and Bera... | PMC10691073 |
Conclusions | RDS | COMPLICATIONS | Considering the effectiveness of neonatal RDS treatment and ventilator-induced complications in these patients, we recommend the use of surfactant replacement therapy. Our scientific study assessed Beraksurf®, an Iranian Survanta, as effective as international surfactant products on neonatal RDS treatment and safe enou... | PMC10691073 |
Acknowledgements | This study was supported by the pediatric health research center at the Kerman University of Medical Sciences. We thank the NICU nurses involved in the care of the neonates studied in this report. | PMC10691073 | ||
Authors’ contributions | F.S. designed the initial concept, prepared the manuscript, and helped with the first draft of the manuscript. B.B., Z.D.P. and Z.J. designed the initial concept. M.E. participated in manuscript preparation and data collection. F.K.R. participated in revising manuscript. All authors read and approved of the final versi... | PMC10691073 | ||
Funding | This study was supported by the pediatric health research center at the Kerman University of Medical Sciences. We thank the NICU nurses involved in the care of the neonates studied in this report. | PMC10691073 | ||
Data Availability | All data generated or analyzed during this study are included in this published article. | PMC10691073 | ||
Declarations | PMC10691073 | |||
Ethics approval and consent to participate | This study was conducted in accordance to the Declaration of Helsinki. The ethics committee of Kerman University of medical sciences approved this study (Code: IR.KMU.AH.REC.1400.012). In addition, this study was approved by the Iranian Registry of Clinical Trials (IRCT) (Code: IRCT20210501051148N1) in 11/07/2021. Writ... | PMC10691073 | ||
Consent for publication | Not applicable. | PMC10691073 | ||
Competing interests | The authors of this study claim no conflicts of interest. | PMC10691073 | ||
List of abbreviations | respiratory distress | respiratory distress syndromepatent ductus arteriosusintraventricular hemorrhagecontinuous positive airway pressurerisk ratioconfidence intervalsneonatal intensive care unitstandard deviation | PMC10691073 | |
References | PMC10691073 | |||
Abstract | PMC10407975 | |||
Objective | weight gain, immature gastrointestinal tract | Feeding intolerance (FI) is a common condition in preterm infants because they have an immature gastrointestinal tract. There are studies on the effects of the position on gastric residual volume (GRV) in preterm infants. Kangaroo mother care (KMC) may be an instrument for reducing FI by providing an upright position t... | PMC10407975 | |
Methods | The population of the study, designed as a randomized trial, consisted of 168 preterm infants [KMC: 84, Standart Care (SC): 84] hospitalized in the neonatal intensive care unit of a university hospital between June and November 2020. Infants were randomly selected and divided into two groups. After the vital signs of t... | PMC10407975 | ||
Results | No statistically significant difference was detected between the groups upon comparing them in terms of demographic and clinical characteristics. The body temperatures and O | PMC10407975 | ||
Conclusion | The present study demonstrated that KMC had a positive impact on FI in preterm infants. KMC is not only a safe care model providing the earliest contact between parents and infants but also a practice whose positive effect on the functioning of the digestive system in preterm infants we can use. | PMC10407975 | ||
INTRODUCTION | Enteral feeding plays an essential part in the survival of preterm infants [Feeding-related nursing care has been accepted as a key factor in increasing the survival rates, health and development of infants with special care needs [Kangaroo mother care (KMC) is a care approach within the scope of developmental care the... | PMC10407975 | ||
METHODS | PMC10407975 | |||
Study design | The research was designed as an experimental trial to demonstrate the effects of KMC on FI in preterm infants. The study population comprised all preterm infants ( | PMC10407975 | ||
Sample selection criteria | breast milk, neurological disease | NEUROLOGICAL DISEASE | Preterm infants who were born between 28 and 36 gestational weeks determined according to the time of mothers' last menstruation and obstetric evaluation results, had low birth weight (weighed between 1000 and 2500 g) during the research, had stable vital signs and could consume 75% of the total protein and energy thro... | PMC10407975 |
Exclusion criteria | NEC, skull fracture, atelectasis | GASTROINTESTINAL DISEASES, ATELECTASIS | Intubated preterm infants without cardiorespiratory stabilization and with pneumothorax, vomiting or bilious-stained gastric aspirate, other gastrointestinal diseases, NEC, skull fracture, severe atelectasis or a history of surgery that might impact their comfort, and a condition that prevented the placement of a chest... | PMC10407975 |
Data collection | To collect the study data, the Descriptive Information Form, KMC Follow-up Form, and GRV Measurement Form were used. | PMC10407975 | ||
Descriptive information form | The form in question contains the descriptive information (age, weight, sex, etc.) of the mother and the infant. | PMC10407975 | ||
KMC follow-up form | Information such as the date of starting KMC, vital signs measured before and after KMC, and the amount of residue (ml) measured before the next feeding (approximately in a 3-h period) is recorded. | PMC10407975 | ||
GRV measurement form | vomiting, abdominal distention | ‘FI’ represents a combination of clinical signs that suggest that an individual cannot tolerate enteral feeding. The most comprehensive definition is presented below: It is the inability to digest more than 50% of enteral feeding presented as GRV, abdominal distention or vomiting, or both of them, and thus disruption o... | PMC10407975 | |
Procedure | hand-foot, NEC, shock, congenital malformations, Breast milk, Breast milk fortification, respiratory distress, breast milk, obstructions | MULTIPLE ORGAN FAILURE, DYSFUNCTION, SHOCK | Before including them in the study, the researcher met with the family and the infant. The study's aim and KMC application were explained to the family. An informed consent form was given to the families who wanted to take part in the study, and the family read it and approved it. The infant's group was determined acco... | PMC10407975 |
Ethical considerations | The study was approved by the Clinical Studies Ethics Committee of Kahramanmaraş Sütçü İmam University in Turkey (Date: 2020/24, Decision No: 03). Written informed consent was obtained from all participants before enrollment into the study. | PMC10407975 | ||
STATISTICS | In the research, the data of 168 participants were assessed and transferred to IBM SPSS Statistics 23 program on the computer. The participants' descriptive characteristics were analyzed with frequency ( | PMC10407975 | ||
RESULTS | weight gain | When the participants in the KMC and SC groups were compared in terms of some descriptive and clinical characteristics, the groups did not differ statistically significantly (Comparison of some descriptive and clinical characteristics by groups
When the participants in the groups were compared in terms of pre-feeding... | PMC10407975 | |
DISCUSSION | volume and gastric emptying, breast milk, abnormal feeding and disorders, weight gain, gastrointestinal dysfunction | DISEASE, GASTROINTESTINAL DYSFUNCTION | FI represents a group of clinical symptoms of abnormal feeding and disorders caused by gastrointestinal dysfunction due to different disease factors in the neonatal period [Nutrition care is one of the primary measures to save preterm infants. In this regard, proper positioning is one of the key measures that is done b... | PMC10407975 |
FUNDING | None. | PMC10407975 | ||
REFERENCES | PMC10407975 | |||
Aims | hip arthroplasty, THA | This article aimed to explore the efficacy of robotic arm-assisted total hip arthroplasty (THA) in improving preoperative planning and intraoperative decision-making. | PMC10440908 | |
Methods | THA | In this single-center, prospective, randomized clinical controlled trial, 60 patients were randomly divided into two groups: conventional THA (cTHA) and robotic arm-assisted THA (rTHA). The rTHA underwent procedures using a robot-assisted surgical system, which generated three-dimensional models to determine the most a... | PMC10440908 | |
Results | anemia | ANEMIA | Sixty patients were included in the study, but one patient was not allocated due to anemia. No significant preoperative baseline data difference was found between the two groups. The actual versus predicted implantation size of both groups revealed that 27/30 (90.0%) in the rTHA group and 25/29 (86.2%) in the cTHA grou... | PMC10440908 |
Conclusion | Robotic arm-assisted total hip arthroplasty can be valuable for preoperative planning and intraoperative decision-making. | PMC10440908 | ||
Keywords | PMC10440908 | |||
Introduction | hip joint diseases, THA, pain | COMPLICATIONS | Total hip arthroplasty (THA) is an effective method for advanced hip joint diseases. At present, the main purpose of THA is to reduce pain and improve the function of the hip joint. Globally, there are more than 1 million THAs every year, and the number is increasing yearly [With the increasing types of prostheses, THA... | PMC10440908 |
Materials and methods | neuromuscular dysfunction, dysplasia, anemia, paralysis, hip arthroplasty, infection, bony ankylosis, arthroplasty, hip deformity | DYSPLASIA, ANEMIA, WEST, INFECTION, DISEASES, ANKYLOSING SPONDYLITIS | This study was a single-center (Orthopedics, West China Hospital, Chengdu, China), prospective, randomized clinical controlled trial including participants aged 18–80 years old. This trial was approved by the Ethics Committee on Clinical Trials, West China Hospital of Sichuan University (HX-IRB-AF-12-V4.0). All patient... | PMC10440908 |
Randomization | The interactive network response system Clinflash IRT v2.2.10 (Clinflash Healthcare Technology, Jiaxing Clinflash Computer Technology Co. Ltd.) automatically distributed groups randomly according to the order of entry to reduce the test bias caused by sampling error. The random table was generated by the specified pers... | PMC10440908 | ||
Intervention | femoral head, THA | A total of 60 patients were randomly divided into two groups: patients who underwent conventional THA (cTHA group) and patients who underwent robotic arm-assisted THA (rTHA group). The patients in the cTHA group underwent preoperative planning, during which the pelvic digital X-ray (enlarged by 100%) was compared to a ... | PMC10440908 | |
Outcome measures | All patients were examined by X-ray and CT within 14 days before surgery. One day before the operation, the planning for the cTHA group was based on X-ray measurements of the size and position of the prosthesis and the length of the lower extremities. The length was determined by drawing a horizontal reference line thr... | PMC10440908 | ||
Statistical analysis | SPSS 27.0 (IBM, Chicago, IL, USA) was used for data analysis. Data were reported as the means and standard deviations or as proportions. The independent-samples t-test was used for continuous data showing a normal distribution, the Mann‒Whitney U test was used for continuous data showing skew, and the chi-squared test ... | PMC10440908 | ||
Discussion | scoliosis, low back pain, THA | SCOLIOSIS, COMPLICATIONS, POSTOPERATIVE COMPLICATIONS | In this prospective randomized clinical controlled trial, the purpose was to investigate the impact of preoperative planning and intraoperative decision-making caused by rTHA. Our results show that compared with cTHA, rTHA reduces leg length difference in lower limbs, and shows similar predictive effects of the size an... | PMC10440908 |
Acknowledgements | We would like to thank the surgeons, nurses, and research staff at our joint center for their support. | PMC10440908 | ||
Author contributions | HPL and QX: drafted the work and provided critical revision for important intellectual content. HPL and HX: performed data collection, analysis, and interpretation. TFY: participated in final approval of the version to be published. ZKZ: contributed to the conception and design of the study, and revised the manuscript.... | PMC10440908 | ||
Funding | This study was supported by Key Research & Development Program of the Science & Technology Department of Sichuan Province (2021YFS0125), Regional Innovation & Cooperation Program of the Science & Technology Department of Sichuan Province (2021YFQ0028). The funders had no role in study design, data collection, data anal... | PMC10440908 | ||
Declarations | PMC10440908 | |||
Ethics approval and consent to participate | WEST | The hospital’s institutional review board approved the study. A statement of the location where the work was performed: The work was performed in Department of Orthopaedic surgery, West China Hospital, Sichuan University. | PMC10440908 | |
Competing interests | No competing interests exits in the submission of this manuscript, and manuscript is approved by all authors for publication. | PMC10440908 | ||
References | PMC10440908 | |||
Background | Healthcare-associated infections | COMPLICATION | Healthcare-associated infections (HAIs) are a common, costly, yet largely preventable complication impacting patients in healthcare settings globally. Improving routine cleaning and disinfection of the hospital environment has been shown to reduce the risk of HAI. Contaminated shared medical equipment presents a primar... | PMC9944767 |
Methods | SECONDARY | The CLEEN study will use a stepped wedge randomised controlled design in 10 wards of one large Australian hospital over 36 weeks. The intervention will consist of 3 additional hours per weekday for the dedicated cleaning and disinfection of shared medical equipment on each ward. The primary outcome is to demonstrate th... | PMC9944767 | |
Discussion | infection | INFECTION | Evidence from the CLEEN study will contribute to future policy and practice guidelines about the cleaning and disinfection of shared medical equipment. It will be used by healthcare leaders and clinicians to inform decision-making and implementation of best-practice infection prevention strategies to reduce HAIs in hea... | PMC9944767 |
Trial registration | Australia New Zealand Clinical Trial Registry ACTRN12622001143718. | PMC9944767 | ||
Keywords | PMC9944767 | |||
Administrative information | WEST, MITCHELL | Note: the numbers in curly brackets in this protocol refer to SPIRIT checklist item numbers. The order of the items has been modified to group similar items (see This project is funded by an NHMRC Emerging Leadership Investigator grant (Prof Brett Mitchell), (GNT2008392), administered by Avondale University.Academic an... | PMC9944767 | |
Introduction
| PMC9944767 | |||
Background and rationale {6a} | infection, infections, healthcare-associated infections | INFECTION, INFECTIONS, EMERGING INFECTIOUS DISEASE | One in 10 patients in an Australian hospital will acquire an infection while in the hospital (1). This equates to approximately 170,000 infections each year (2). These hospital-acquired infections represent just a subset of the total number of healthcare-associated infections (HAIs), which include infections associated... | PMC9944767 |
Objectives {7} | Objective 1: Assess the effectiveness of improving the quality and frequency of cleaning and disinfection of shared medical equipment in reducing HAIs.Objective 2: Evaluate the cost-effectiveness of the intervention. | PMC9944767 | ||
Trial design {8} | This study is a stepped wedge randomised controlled study, conducted in 10 wards of one acute Australian hospital over 36 weeks. A stepped wedge design allows all wards to receive the intervention at different times, with each ward acting as its own control. Each cluster will comprise two wards. One cluster will switch... | PMC9944767 | ||
Methods: participants, interventions and outcomes | PMC9944767 | |||
Study setting {9} | One Australian hospital that meets the eligibility criteria will be enrolled in the study. Ten wards within the hospital will be selected for the study. | PMC9944767 | ||
Eligibility criteria {10} | ’ | The eligible hospital will meet the following criteria: classified as a ‘Public acute group A hospital’ by the Australian Institute of Health and Welfare (9), located in New South Wales, have an intensive care unit, have a minimum of 10 wards, and caring for adult patients (i.e. ≥ 18 years old) willing to participate i... | PMC9944767 | |
Who will take informed consent? {26a} | infections, healthcare-associated infections | INFECTIONS | This project collects data associated with human beings only. Data from all patients (> 18 years old) who are inpatients on one of the 10 wards on the day of the PPS will be used. As this project collects data associated with human beings only, there is no consent process and a waiver of consent has been sought and gra... | PMC9944767 |
Additional consent provisions for collection and use of participant data and biological specimens {26b} | Not applicable—no biological specimens will be collected for this study. | PMC9944767 | ||
Interventions | PMC9944767 | |||
Explanation for the choice of comparators {6b} | FM | The stepped wedge study design allows each ward to act as its own control. During the control phase, the cleaning and disinfection of shared medical equipment are undertaken by PSAs according to hospital policies. The intervention phase introduces 15 additional hours per week, purely dedicated to the cleaning and disin... | PMC9944767 | |
Intervention description {11a} | The intervention will consist of additional time dedicated to cleaning and disinfection of shared medical equipment, education on cleaning technique, auditing of cleaning efficacy and feedback on cleanliness to staff. This multimodal strategy to improve the cleaning and disinfection of shared patient equipment is groun... | PMC9944767 | ||
Additional cleaning | During the intervention phase, each trial ward will receive an additional 3 h of cleaning per weekday by dedicated cleaners. This is in addition to routine cleaning that already occurs. The use of dedicated cleaners will reduce the risk of contamination and assist in consistency in implementation. An expression of inte... | PMC9944767 | ||
Education | The dedicated cleaners undertaking the additional cleaning will undergo education and training sessions prior to the commencement of the intervention. Education prior to the invention will include at least a 1-h in-service, where cleaning techniques will be taught and practised. This will occur no longer than 2 months ... | PMC9944767 | ||
Audit and feedback | dry abrasion, Infection, FM | INFECTION | The benefits and role of audit, including the use of fluorescent markers (FM), in assessing environmental cleaning, is well documented (7,13,14). Audit and feedback to the cleaning staff involved in the additional cleaning will include the use of FM technology, in which invisible gel dots that are removed by cleaning a... | PMC9944767 |
Criteria for discontinuing or modifying allocated interventions {11b} | The study will be discontinued if a regulatory body, funding body or the HREC judges it necessary for medical, safety, regulatory or other reasons consistent with applicable laws, regulations and good clinical practice. | PMC9944767 | ||
Strategies to improve adherence to interventions {11c} | FM | To improve adherence to intervention protocols, there will be educational training sessions that focus on correct cleaning techniques. Refresher training sessions for PSAs will be held during the intervention period to promote correct cleaning and disinfection techniques. The study coordinator will have regular communi... | PMC9944767 | |
Relevant concomitant care permitted or prohibited during the trial {11d} | Not applicable—as there is no direct intervention for patients. | PMC9944767 |
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