title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
|---|---|---|---|---|
Patients and methods | PMC9926577 | |||
Data source and study cohort | OPSCC, Cancer | CANCER | From the Taiwan Cancer Registry Database (TCRD), we enrolled patients who had received a diagnosis of p16-negative OPSCC between January 1, 2008, and December 31, 2018. The follow-up duration was from the index date to December 31, 2019. Biomarkers commonly used in clinical practice include p16 expression (determined t... | PMC9926577 |
Selection of cases and controls | OPSCC, AJCC, Cancer | CANCER, METASTASIS, CANCER | Inclusion criteria were having a diagnosis of p16-negative OPSCC, being aged > 20 years, and having American Joint Committee on Cancer (AJCC) clinical stage I–IVA cancer without metastasis. The AJCC 8 | PMC9926577 |
Study covariates | comorbidity | Comorbidities were scored using the Charlson comorbidity index (CCI). | PMC9926577 | |
Statistical analysis | REGRESSION | The cumulative mortality rate was estimated using the Kaplan–Meier method. Differences between the pre-CCRT PET–CT and non-pre-CCRT PET–CT groups were determined using the log-rank test. After adjustment for confounders, the Cox proportional regression model was used to model the time from the index date to all-cause m... | PMC9926577 | |
Results | PMC9926577 | |||
Survival curves of case and control groups | oropharyngeal squamous cell carcinoma | OROPHARYNGEAL SQUAMOUS CELL CARCINOMA | Figure Kaplan–Meier curves of overall survival for patients with all stages of p16-negative oropharyngeal squamous cell carcinoma receiving concurrent chemoradiotherapyKaplan–Meier curves of overall survival for patients with early stages of p16-negative oropharyngeal squamous cell carcinoma receiving concurrent chemor... | PMC9926577 |
Discussion | OPSCC, head and neck cancers, toxicity, stroke, AJCC | STROKE, RECURRENCE, CARDIOVASCULAR DISEASE, HEAD AND NECK CANCER | According to the NCCN guidelines [Most previous studies have investigated both p16-positive and p16-negative OPSCC [Many studies have reported that PET–CT can be used for determining the response to treatments, including CCRT, or for the detection of recurrence in head and neck cancers [Compared with the control group,... | PMC9926577 |
Conclusions | Routine use of pre-CCRT | PMC9926577 | ||
Acknowledgements | Lo-Hsu Medical Foundation, LotungPoh-Ai Hospital, supports Szu-Yuan Wu’s work (Funding Numbers: 110908, 10909, 11001, 11002, 11003, 11006. The data sets supporting the study conclusions are included in the manuscript. | PMC9926577 | ||
Author contributions | Conception and Design: Tsung-Ming Chen, MD; Wan-Ming Chen, MS, PhD; Mingchih Chen, PhD; Ben-Chang Shia, PhD; Szu-Yuan Wu, MD, MPH, PhD. Financial Support: Lo-Hsu Medical Foundation, LotungPoh-Ai Hospital, supports Szu-Yuan Wu’s work (Funding Number: 10908, 10,909, 11,001, 11,002, 11,003, 11,006, and 11,013). Collection... | PMC9926577 | ||
Funding | Lo-Hsu Medical Foundation, LotungPoh-Ai Hospital, supports Szu-Yuan Wu’s work (Funding Number: 10908, 10909, 11001, 11002, 11003, 11006. | PMC9926577 | ||
Availability of data and materials | Cancer | CANCER | We used data from the National Health Insurance Research Database and Taiwan Cancer Registry database. The authors confirm that, for approved reasons, some access restrictions apply to the data underlying the findings. The data used in this study cannot be made available in the manuscript, the supplemental files, or in... | PMC9926577 |
Declarations | PMC9926577 | |||
Ethics approval and consent to participate | Cancer | CANCER | The study protocols were reviewed and approved by the Institutional Review Board of Tzu-Chi Medical Foundation (IRB109-015-B). We used data from the National Health Insurance Research Database and Taiwan Cancer Registry database. The authors confirm that, for approved reasons, some access restrictions apply to the data... | PMC9926577 |
Consent for publication | Authors provide a full Transfer of Copyright to Journal of Otolaryngology-Head & Neck Surgery. | PMC9926577 | ||
Competing interests | Competing | No Competing interests. | PMC9926577 | |
References | PMC9926577 | |||
Background | dengue | DENGUE, DISEASES, CHIKUNGUNYA | Arbovirus diseases such as dengue, Zika, and chikungunya are a public health threat in tropical and subtropical areas. In the absence of a vaccine or specific treatment, vector management (in this case the control of the primary vector | PMC10227988 |
Methods | DENGUE, DISEASE | Baseline surveys were conducted in 5,997 households, randomly selected from 24 clusters (neighbourhoods with on average 2000 houses and 250 households inspected) in the metropolitan area of Cucuta, Colombia. The study established population characteristics including water management and mobility as well as larval-pupal... | PMC10227988 | |
Results | INFESTATION, DISEASE | In all 24 study clusters similar social and demographic characteristics were found but the entomological indicators and estimated disease incidence rates varied. The entomological indicators showed a high vector infestation: House Index = 25.1%, Container Index = 12.3% and Breteau Index = 29.6. Pupae per person Index (... | PMC10227988 | |
Conclusions | The production of | PMC10227988 | ||
Supplementary Information | The online version contains supplementary material available at 10.1186/s12889-023-15893-4. | PMC10227988 | ||
Keywords | Open Access funding enabled and organized by Projekt DEAL. | PMC10227988 | ||
Introduction | dengue, Arboviral diseases, arboviral disease, Zika | ARBOVIRAL DISEASE, DENGUE, INFESTATION, CHIKUNGUNYA | Arboviral diseases such as dengue, Zika and chikungunya (DZC) are a public health threat in tropical and sub-tropical countries due to the increase of the global burden promoted by the rapid spread of their mosquito vectors, In Colombia, The transmission risk of arboviral disease outbreaks in endemic regions has tradit... | PMC10227988 |
Methods | PMC10227988 | |||
Place of study | DEL | The study was conducted within 2.5 months in 2019–20 in Metropolitan Cucuta in the North-East of Colombia, including the city of Cucuta (629,414), and two adjacent municipalities Villa del Rosario (93,735) and Los Patios (81,411 inhabitants) located in the Norte de Santander state [ | PMC10227988 | |
Study design and sample size | This is the baseline study (using a cluster design) for a large cluster randomized trial on the impact of treating water containers with a protective paint. The sample size was calculated for detection of a 50% reduction in the House Index with > 99% power at 5% significance level. Given a baseline HI of 30%, an intra-... | PMC10227988 | ||
Sampling procedure for household survey and entomological inspections | On the basis of available maps, the city was stratified into high, middle and low endemic/infested areas for Selection of clusters in CucutaMap shows the 16 clusters selected in Cucuta which were visited by interviewers and vector control staffVector control staff and trained interviewers participated in the survey. Th... | PMC10227988 | ||
Data collection | The baseline surveys included a household questionnaire and entomological survey (see Additional files | PMC10227988 | ||
Household questionnaire | Demographic and health data was collected through face-to-face interviews using a standard questionnaire that included both structured and semi- structured questions. Household questionnaire was adapted from published research in Colombia [ | PMC10227988 | ||
Entomological survey | The standard entomological survey form was adapted following the guidelines of Standard Operational Procedures (SOPs) by WHO [ | PMC10227988 | ||
Dengue surveillance and case definition | dengue fever, dengue, DF | DENGUE FEVER, DENGUE | Data of the national surveillance system were obtained from SIVIGILA (the national health surveillance system), aggregated by year and setting (study areas) over the study period. Notified dengue cases including those classified as dengue fever (DF) and severe dengue, relying on a clinical case definition or lab confir... | PMC10227988 |
Data management and analysis | DENGUE FEVER | Descriptive analyse and double data entry was practiced (to minimize data entry errors) into a database using Microsoft Office Excel software by an assistant and supervised by the research team. The analysis was done using SPSS software version 28.0.1.1 (15).Socio-demographic data were entered in a database. We assesse... | PMC10227988 | |
Ethical considerations | ALBERT | The household questionnaire was only applied to adults who provided information related to the purpose of this study. No child or adolescent below the age of 18 was interviewed in this study. All people participating in the study were informed in local language through the study information sheet in a written and oral ... | PMC10227988 | |
Results | In the baseline survey, a total of 5,997 households with 23,408 people in 24 clusters were visited by the field team. Some data were missing, or some questions were not answered by household participants, these values were excluded from the analysis. | PMC10227988 | ||
Peoples’ mobility | The insect vector | PMC10227988 | ||
Epidemiological information | dengue, arboviral disease | CHIKUNGUNYA, DENGUE, MIXED INFECTION, DEL, DENGUE, CHIKUNGUNYA, ARBOVIRUS DISEASE | Across all clusters, 2.0% (468/23,093) of household members reported to have had any arboviral disease (DZC) during the last 12 months (Dengue incidence was 0.84%). This ranged from 3.0% (116/3,814) in Los Patios, 2.3% (90/3,948) in Villa del Rosario, to 1.7% (262/15,331) in Cucuta. A small group of respondents (68 per... | PMC10227988 |
Dengue incidence notified by the National surveillance system, 2015–2021 | dengue | DENGUE | During the 7-year period, 2015–2021, 8,190 dengue cases were notified by SIVIGILA in the study areas. The number of annual case notifications varied from a low of 333 cases in 2020 (173.1 per 100,000 population) to a high of 1,949 cases in 2019 (1,013.4 per 100,000 population), with a mean of 1,170 cases per year (inci... | PMC10227988 |
Most infested container types | A total of 14,386 water holding containers were found in the entomological inspection. These included containers used for water storage as well as some discarded mainly small containers not used for water storage but in which water had accumulated. Overall, the most common containers were concrete ground tanks (48.5%; ... | PMC10227988 | ||
Pupal productivity in different water container types | DEL | The total number of pupae collected across all cluster was 20,400. Of these 13,800 pupae were collected from the clusters in Cucuta (271 households) with a median of 50.9 total pupae per household; 2,328 pupae were collected from the 4 clusters of the municipality of Los Patios (80 households) with a median of 29.1 and... | PMC10227988 | |
Ground tanks and water use | SEPARATION | Characteristics of the concrete ground tanks (Regarding the sources of drinking water, only 2.2% (133/5,997) of the houses take drinking water from these ground tanks while the majority uses it for laundry (97.8%) and drink water from the tap provided by the municipal water company. We observed in our survey that peopl... | PMC10227988 | |
Willingness to receive a new vector control intervention | DISEASES, ARBOVIRUS DISEASE | The community in all clusters was interested in receiving the proposed novel vector control method (insecticidal coating for water containers). Overall, 88.3% of respondents held this view and there was no significant difference between clusters (5,296/5,997). The experience of the vector control staff (24 inspectors) ... | PMC10227988 | |
Discussion | arboviral diseases | This study is designed as the baseline study for a large Cluster Randomized Trial (CRT) but provides also by itself important information on the: epidemiological, entomological, and socio-demographic characteristics and assesses the transmission risk of arboviral diseases in an endemic area of Colombia. | PMC10227988 | |
Vector infestation level | The field team reported similar socio demographic characteristics in all clusters, but entomological characteristics were varied. High vector densities were found throughout all clusters. All clusters had a HI above 5% (range 6.0%-37.5%; Table | PMC10227988 | ||
Main Ae. aegypti breeding sites | Concrete ground tanks were the most common type of water containers in all clusters. The population in Cucuta has historically collected water for multiple uses as a common practice of their daily routine due to the occasional shortage of tap water which has been a continuous problem in the region and other parts of th... | PMC10227988 | ||
Vector control | In Colombia, vector control, such as the application of the organophosphate temephos in ground water containers, is generally only practiced in epidemic situations. For routine control, communities are recommended to keep containers covered and clean [This study showed that almost half of the population (48.7%) had not... | PMC10227988 | ||
Considerations for the forthcoming intervention study | toxicity, Chagas disease, leishmaniasis | SECONDARY, CHAGAS DISEASE, LEISHMANIASIS | This study provides cluster specific information on socio-economic indicators and cluster size, on the estimated mosquito abundance, the main breeding places and their pupal productivity, the type and size of water containers, water use for drinking and cleaning which should be considered for the planning of the interv... | PMC10227988 |
Limitations | infection | INFECTION | Although some studies have shown an association between arbovirus infection and occupation [ | PMC10227988 |
Acknowledgements | DIAZ, DEL | The authors would like to thank the participating families in this study. We gratefully acknowledge the team of the Centre for Medicine and Society, Master Programme Global Urban Health at Freiburg University, particularly Dr. Sonia Diaz for her encouragement and support on this work. We thank the vector control team i... | PMC10227988 | |
Authors’ contributions | MP | All authors contributed to the concept and design of the study. MAC, RCS and AK did the interviewer training, and drafted the paper. All authors read and approved the study and the procedures. MAC and RCS prepared the submission to the ethical committee and prepared the logistics. MAC, RCS and JY prepared the field stu... | PMC10227988 | |
Funding | Open Access funding enabled and organized by Projekt DEAL. MAC and RCS received a scholarship for their doctoral studies from the Ministry of Science, Technology and Innovation (Minciencias) and the State of Norte de Santander in Colombia (Grant number: 753, program: The article processing charge was funded by the Germ... | PMC10227988 | ||
Availability of data and materials | All data generated or analysed during this study are included in this published article (Additional file | PMC10227988 | ||
Declarations | PMC10227988 | |||
Ethics approval and consent to participate | The participation in this study was voluntary, anonymous and did not represent a risk for the participants or their families. This study did not include human participants that are minors. Socio-demographic information was provided by a household participant (the head of house or parent) who had to be at least 18 years... | PMC10227988 | ||
Consent for publication | Not applicable. | PMC10227988 | ||
Competing interests | The authors declare no competing interests. | PMC10227988 | ||
References | PMC10227988 | |||
Background | This study aimed to determine the effect of telephone counseling based on Orem’s Self-Care Model on adherence to treatment and resilience of patients with coronary angioplasty. | PMC10552216 | ||
Methods | cardiovascular and respiratory diseases | This randomized clinical trial was performed on 80 patients in the Cardiac Intensive Care Unit of Shiraz University of Medical Sciences. Patients were randomly divided into two groups of 40 (intervention and control). Questionnaires on adherence to treatment of chronic patients and resilience for patients with cardiova... | PMC10552216 | |
Results | Before the intervention, no significant difference was found between the groups about adherence to treatment and resilience. However, after the intervention, a significant difference was found between the groups as to adherence to treatment and resilience (P < 0.001). | PMC10552216 | ||
Conclusion | Nursing consultation using telephone calls based on Orem’s model increases the adherence to treatment and resilience of patients undergoing coronary angioplasty. Telephone counseling can help the patients adhere to their treatment plans and develop resilience skills. | PMC10552216 | ||
Keywords | PMC10552216 | |||
Introduction | death, traumatic, disability, ’ | DISORDER, CARDIOVASCULAR DISEASE, DISEASE, EVENTS, CORONARY ARTERY DISEASE, COMPLICATIONS | Cardiovascular diseases are predicted to be the main cause of death and disability in the world by 2030 [One of the behaviors related to the disease and self-care is patients’ adherence to a treatment regimen that can predict successful treatment and reduce the severity of the disease and its complications [Resilience ... | PMC10552216 |
Methods | PMC10552216 | |||
Design | The present study was a randomized clinical trial. This was registered in the Iranian Registry of Clinical Trail (Number IRCT20210303050562N1, approved 18/06/2021). ( | PMC10552216 | ||
Setting | The study was performed at eight Cardiac Intensive Care Unit (CCU) wards in the hospitals affiliated with Shiraz University of Medical Sciences in 2021. | PMC10552216 | ||
Eligibility criteria for participants | mental illness | The inclusion criteria of the study were being hospitalized post-PCI patients; ranging in age from 18 to 65 years; being able to communicate and no hearing or speech problems; having access to mobile or landline phone and ability to use it; being able to read and write; and being able to perform daily activities. On th... | PMC10552216 | |
Sample size | The research sample size was determined using medcalc software and the study conducted by Akhu-Zaheya et al. (2017) [ | PMC10552216 | ||
Randomization | BLIND | To conduct the randomization, we firstly selected eight CCU wards as eight separate strata. Then, using a statistical software and eight separate strata, we prepared a list of random allocation for 80 subjects. A statistician who was not a member of the research team generated the list and made sequentially numbered co... | PMC10552216 | |
Blinding | BLIND | In this study, the individual who collected the data and the statistician were blind to the groups. Also, the outcomes were assessed by a blinded examiner before and 8-weeks after the intervention. Moreover, the researcher who selected the participants and allocated them to the groups was blind to them.
Flowchart of th... | PMC10552216 | |
The intervention | heart disease | DISEASE, HEART DISEASE | In the interventional group, in addition to educational pamphlets and routine hospital care, telephone counseling was performed for 8 weeks. It was conducted by a MSc nurse that had 3 years of experience working as a nurse in CCU wards. Each patient gave us his/her contact number as well as that of a family member; the... | PMC10552216 |
The control group | DISEASE | The control group received routine care without any interventions. The patients received the routine care as follows: educational pamphlets and standard hospital care including education about diet, activity, medications, and educational pamphlets about disease and medicine, and the way to see a doctor at the time of d... | PMC10552216 | |
Outcomes | diabetes | HYPERLIPIDEMIA, HYPERTENSION, HEART DISEASE, DIABETES | Data collection tools included demographic and clinical characteristics forms, adherence to treatment of chronic patients (Modanloo 2013) [The demographic and clinical characteristics form which was collected at a baseline included information on the patient’s age, gender, marital status, educational level, job, body m... | PMC10552216 |
Adherence to treatment | Modanloo’s Chronic Patients Adherence Questionnaire was used to assess adherence to the treatment of heart patients in various dimensions (acceptance of medication, diet, weight control, physical activity, follow-up time for treatment, and lifestyle changes). This scale has 40 items in the form of 7 subscales in the ar... | PMC10552216 | ||
Resilience | cardiovascular and respiratory diseases | Resilience for patients with cardiovascular and respiratory diseases was designed by Ebadi et al. in 2016. This scale has 29 items with 5 subscales in the dimensions of positive adjustment (10 questions), self-management dimension (7 questions), rational empowerment dimension (7 questions), treatment adherence dimensio... | PMC10552216 | |
Ethical considerations | We obtained the code of ethics (1400.167. IR.SUMS.REC) from the Research Ethics Committee of Shiraz University of Medical Sciences; we also obtained permission from the University of Medical Sciences and related hospitals. The written informed consent was signed by the participants in the study. They were assured of th... | PMC10552216 | ||
Statistical analyses | diabetes | HEART DISEASE, HYPERLIPIDEMIA, REGRESSION, HYPERTENSION, DIABETES | To describe the findings, we used the mean, frequency percentage, variance, and standard deviation. To determine the confounders and other factors that might be associated to adherence to treatment and resilience, we used multiple linear regression analysis. It showed that age, gender, marital status, educational level... | PMC10552216 |
Results | PMC10552216 | |||
Sample characteristics | The final sample of 80 respondents was randomly assigned into two groups of 40, intervention and control subjects. The youngest participant in this study was 41 years old and the oldest was 65 years old, and the mean age of the participants was 56.60 ± 5.546 years. According to the Mann-Whitney test, there was no signi... | PMC10552216 | ||
Discussion | heart failure, cardiovascular diseases | HEART FAILURE, CARDIOVASCULAR DISEASES | The results of the study showed that there was a difference between the two groups in terms of adherence to treatment and resilience after the intervention. The results of the present study also showed that the mean scores of adherence to treatment and resilience were significantly different in the intervention group b... | PMC10552216 |
Conclusion | DISEASE, COMPLICATIONS | The results of the present study showed that nursing counseling by telephone based on the Orem’s model increased the adherence to treatment and resilience of patients who had undergone coronary angioplasty. Therefore, mobile counseling, as an inexpensive method, can change the focus of the treatment and care from the c... | PMC10552216 | |
Acknowledgements | RCC | RCC | This article is the result of a Master’s thesis (NO: 22289) in the School of Nursing and Midwifery of Shiraz University of Medical Sciences. We would like to express our sincere thanks and appreciation to the Vice Chancellor for Research and Graduate Studies of the University, the esteemed officials and staff of the ho... | PMC10552216 |
Author contributions | Khatereh Rostami, Mahsa Maryami, and Masoume Rambod contributed to this study. All of the authors participated in conceptualization, designed, drafted, read, and revised the manuscript, and approved the study and manuscript. Khatereh Rostami, Mahsa Maryami, and Masoume Rambod participated in data collection management.... | PMC10552216 | ||
Funding | This work was supported by Shiraz University of Medical Sciences, Shiraz, Iran. (NO: 22289) | PMC10552216 | ||
Data Availability | The data that support the findings of this study are available from [Khatereh Rostami], but restrictions apply to the availability of these data, which were used under license for the current study, so they are not publicly available. Data are, however, available from the authors upon reasonable request and with permis... | PMC10552216 | ||
Declarations | PMC10552216 | |||
Ethics approval and consent to participate | We obtained the code of ethics (1400.167. IR.SUMS.REC) from the Research Ethics Committee of Shiraz University of Medical Sciences and we confirm that all methods were performed in accordance with the relevant guidelines and regulations. The study received the code of IRCT20210303050562N1 (Registration date: 18/06/2021... | PMC10552216 | ||
Consent for publication | Not applicable. | PMC10552216 | ||
Competing interests | The authors declare that they have no competing interests. | PMC10552216 | ||
References | PMC10552216 | |||
Background | shock | SHOCK | High dose vasopressors portend poor outcome in vasodilatory shock. We aimed to evaluate the impact of baseline vasopressor dose on outcomes in patients treated with angiotensin II (AT II). | PMC10163684 |
Methods | hypotensive, Shock, shock | HYPOTENSIVE, SHOCK, SHOCK | Exploratory post-hoc analysis of the Angiotensin II for the Treatment of High-Output Shock (ATHOS-3) trial data. The ATHOS-3 trial randomized 321 patients with vasodilatory shock, who remained hypotensive (mean arterial pressure of 55–70 mmHg) despite receiving standard of care vasopressor support at a norepinephrine-e... | PMC10163684 |
Results | Of 321 patients, the median baseline NED in the low-NED subgroup was similar in the AT II (n = 56) and placebo (n = 48) groups (median of each arm 0.21 µg/kg/min, | PMC10163684 | ||
Supplementary Information | The online version contains supplementary material available at 10.1186/s13054-023-04446-1. | PMC10163684 | ||
Keywords | PMC10163684 | |||
Introduction | death, shock | VASODILATORY SHOCK, SHOCK | Vasodilatory shock is the most common form of shock and can result in high rates of organ failure and death [Angiotensin II (AT II) is an endogenous peptide hormone and a component of the renin–angiotensin–aldosterone system (RAAS). This compound has a unique mechanism of action, distinct from those of catecholamines a... | PMC10163684 |
Methods | PMC10163684 | |||
Study design | The design of ATHOS-3 has been previously reported [ | PMC10163684 | ||
Patients | shock | SHOCK | Patients enrolled in ATHOS-3 were ≥ 18 years of age with vasodilatory shock, MAP of 55–70 mmHg, despite adequate volume resuscitation and receipt of vasopressors at a dose > 0.2 µg/kg/min NED for 6–48 h prior to enrollment; background vasopressor use was not standardized and included catecholamines and vasopressin base... | PMC10163684 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.