title stringlengths 1 1.19k | keywords stringlengths 0 668 | concept stringlengths 0 909 | paragraph stringlengths 0 61.8k | PMID stringlengths 10 11 |
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Design and methods | HTN, hypertension, kidney dysfunction | HTN, KIDNEY DYSFUNCTION, SECONDARY, -11, HYPERTENSION | In an open prospective single-center study, we included patients with suspected resistant HTN referred to the center at Almazov National Medical Research Center (St Petersburg, Russia) which is recognized as one of the ESH hypertension excellence centers. These patients were recruited for endovascular radiofrequency RD... | PMC10668416 |
Examination | microalbuminuria | All patients underwent physical examination, anthropometry, office BP measurements, ambulatory blood pressure monitoring (ABPM), fasting blood tests for renal function assessment (creatinine, eGFR), lipids and glucose, urine for microalbuminuria, renal Doppler ultrasonography (Vivid-7, General Electric, USA), renal CT ... | PMC10668416 | |
Anthropometry | Among anthropometric measurements, we assessed height (accuracy up to 0.5 cm), weight (accuracy up to 100 g), and waist and hip circumferences (in cm) and calculated body mass index (BMI): weight (kg)/height | PMC10668416 | ||
Office BP measurements | HTN, Hypertension | HYPERTENSION, HTN | Office BP measurements were performed at all visits according to the guidelines on the management of HTN of the European Society of Cardiology/European Society of Hypertension (ESC/ESH) [ | PMC10668416 |
Ambulatory BP monitoring | Ambulatory BP monitoring (ABPM) was performed with the use of a certified oscillometric device (BPLab, “Piotr Telegin” LLC, Russian Federation). The measurements were performed every 15 min during the day (08:00–22:00), and every 30 min during night (22:00–08:00). The nighttime period was later corrected according to t... | PMC10668416 | ||
Blood tests | low-density lipoproteins, Dyslipidemia | DYSLIPIDEMIA | The following blood tests were assessed in a fasting state: lipids, serum creatinine, glucose, and insulin (Cobas e411 and Cobas Integra 400 plus, Switzerland; reagents from Roche-diagnostics, Germany). The lipid panel included the total cholesterol (TC), low-density lipoproteins (LDL). Dyslipidemia was diagnosed when ... | PMC10668416 |
Sleep study | thoracic and abdominal respiratory movements, snoring, SDB | In-hospital unattended full polysomnography (PSG) was performed at cardiology department before RDN and at 1-year follow-up. The recordings included the following traces: electroencephalogram, electrooculogram, electromyogram of chin muscles, electrocardiogram, oronasal airflow (via both nasal cannulas and thermistor),... | PMC10668416 | |
Renal denervation procedure | Vessix™ Renal Denervation, W. | RENAL, ACUTE KIDNEY INJURY, CONTRAST-INDUCED NEPHROPATHY | All patients underwent renal angiography via Seldinger technique followed by bilateral RDN. Three specialized endovascular ablation systems were used: Symplicity flex™ (Medtronic Inc, Mountain View, Canada) in 22 patients, Vessix™ Renal Denervation System (Boston Scientific, USA) in 27 patients, and Symplicity Spyral™ ... | PMC10668416 |
Follow-up and outcomes | SDB | The follow-up visits were performed regularly at 3, 6, 12, 24, 36 months. In this analysis, the long-term follow-up data (> 1 year) are presented.At follow-up visits clinical investigation included physical examination, anthropometry, office BP measurements, ABPM, blood tests. Follow-up sleep study (full polysomnograph... | PMC10668416 | |
Statistical analysis | REGRESSION | Descriptive statistics included the mean and standard deviation values for the normally distributed variables and median (minimum-maximum) for non-normally distributed variables. Due to the sample size < 50, the Shapiro-Wilk test was applied to assess the distribution.We applied a frequency analysis (the chi-square) to... | PMC10668416 | |
Results | PMC10668416 | |||
Patient characteristics at baseline | HTN, Epworth sleepiness, Vessix™ Renal Denervation, SDB, dyslipidemia | RENAL, OBESE, CARDIOVASCULAR DISEASES, HTN, TYPE 2 DIABETES MELLITUS, DYSLIPIDEMIA | Out of forty-one patient with baseline sleep study, twenty-eight patients (including 16 patients with SDB at baseline) underwent sleep study at follow-up (Table
The baseline characteristics of patients who underwent baseline and follow-up sleep studyBMI – body mass index, BP – blood pressure, SBP – systolic blood pres... | PMC10668416 |
Follow-up | Epworth sleepiness, sleep-disordered, SDB | OBSTRUCTIVE SLEEP APNEA, ADVERSE EFFECTS | The short-term results and adverse effects were described earlier [In the present analysis, the average follow-up comprised 30.1 ± 8.4 months and was similar in SDB and non-SDB groups (31.1 ± 7.4 vs. 32.0 ± 6.0 months, The number of antihypertensive drugs decreased significantly (4.4 ± 1.1 vs. 3.8 ± 1.0, At long-term f... | PMC10668416 |
Changes in sleep-disordered breathing and sleep characteristics | apnea-hypopnea, OSA, SDB | SLEEP-DISORDERED BREATHING | Although the number of patients with verified SDB increased at follow-up (16 vs. 22), the SDB status (yes/no) changed insignificantly: one patient with baseline SDB demonstrated no OSA at follow-up and 3 patients without baseline SDB demonstrated AHI ≥ 5 episodes/h at follow-up (
Changes in sleep-disordered breathing a... | PMC10668416 |
BP response | SDB | The short-term BP response in our cohort was described previously [The number of non-dippers in SDB (baseline) group increased from 9 to 12 patients, while it remained the same in non-SDB group (2 vs. 2 patients, χThe baseline AHI, ODI and mean SpOThe follow-up indices of SDB severity did not show association with the ... | PMC10668416 | |
Discussion | HTN, OSA, apnea, hypoxemia, OSA deterioration, cardiovascular regulation disturbance, SDB | DISEASE, SECONDARY, HTN | Our study demonstrated that at 3-year follow-up after RDN there is a worsening of OSA, i.e. an increase in the severity indices (AHI, ODI, hypoxemia burden). However, these changes are not associated with the BP response.To our knowledge our study is the first to assess sleep parameters over 1 year after RDN. Our resul... | PMC10668416 |
Conclusion | desaturation, obstructive sleep apnea, OSA, hypertension, apnea-hypopnea | OBSTRUCTIVE SLEEP APNEA, HYPERTENSION | At long-term (> 12 months) follow-up after renal denervation the severity of obstructive sleep apnea is not attenuated, but worsened with the increase in apnea-hypopnea and desaturation indices and the decrease in mean nocturnal oxygen saturation.Although the severity of OSA worsens at > 12 months follow-up after RND, ... | PMC10668416 |
Acknowledgements | Not applicable. | PMC10668416 | ||
Authors’ contributions | RECRUITMENT | LS was responsible for conception, data collection, data analysis and interpretation, drafting and editing the article;MI was responsible for patient recruitment, data collection, data analysis and interpretation, critical revision of the article; ES was responsible for data collection, drafting the article; MB was res... | PMC10668416 | |
Funding | The work was supported by the Ministry of Science and Higher Education of the Russian Federation, agreement No. 075-15-2022-301 dated by 20.04.2022. | PMC10668416 | ||
Data Availability | The data that support the findings of this study are available on reasonable request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. | PMC10668416 | ||
Declarations | PMC10668416 | |||
Ethics approval and consent to participate | -11 | The study was performed in accordance with the principles of Good Clinical Practice and 2013 Declaration of Helsinki. The study protocol was approved by the Scientific Council of Almazov National Medical Research Centre on 23.12.2011 (protocol №11), and later the updated version of the protocol was approved in 2018 by ... | PMC10668416 | |
Consent for publication | Not applicable. | PMC10668416 | ||
Competing interests | LS, MI, ES, MB, IE, YY, SM, DZ, DL, AV, NA, NZ, EM, YS, AK: no conflict of interest. | PMC10668416 | ||
References | PMC10668416 | |||
Introduction | SIRS | SYSTEMIC INFLAMMATORY RESPONSE SYNDROME | Systemic inflammatory response syndrome (SIRS) is related to increased
circulating endothelial microparticles (EMP). | PMC10610908 |
Objective | INFLAMMATORY RESPONSE | The aim of this study was to compare the plasma concentration of EMP between
patients undergoing aortic valve replacement with conventional bioprosthesis
implantation and Perceval™ S (LivaNova) and to evaluate its impact on
the inflammatory response in the short-term follow-up. | PMC10610908 | |
Methods | SIRS, aortic valve replacement | This is a randomized clinical trial with 24 patients submitted to isolated
aortic valve replacement divided into two groups: Perceval™ S (Group
P) and conventional bioprostheses (Group C). Incidence of severe SIRS (three
or more criteria) in the first 48 hours postoperatively, EMP release
profile, interleukins (IL) 6 a... | PMC10610908 | |
Results | SIRS | There were 24 patients (12 in each group), mean age was 69.92±5.17
years, 83.33% were female, the incidence of severe SIRS was 66.7% and 50% in
groups C and P, respectively (P=0.68), and EMP showed a significant increase
in the 24-hour postoperative period (P≤0.001) and subsequent decrease
in the three-month postoperat... | PMC10610908 | |
Conclusion | SIRS | The incidence of severe SIRS was similar in both groups, with significantly
higher levels of IL-6 and IL-8, at the 24-hour postoperative period, in
group C, however with higher levels of EMP in group P, and subsequent return
to baseline levels at the three-month postoperative period in both
groups. | PMC10610908 | |
INTRODUCTION | TAVI, aortic valve diseaseEndothelial dysfunction, aortic valve stenosis, (SIRS)Transcatheter aortic valve, aortic stenosis, MP | AORTIC STENOSIS, AORTIC VALVE STENOSIS, PATHOGENESIS, INFLAMMATORY RESPONSE | In patients with aortic valve stenosis undergoing valve intervention, the
inflammatory response is a frequent finding, both in the pathogenesis of calcified
aortic valve diseaseEndothelial dysfunction presents in patients with aortic stenosis and after valve
replacement surgery and elevates the number of circulating en... | PMC10610908 |
METHODS | PMC10610908 | |||
Study Design | This is a single-center, unblinded, randomized, controlled, and comparative
clinical trial. | PMC10610908 | ||
Participants | mellitus, chronic kidney disease, valve stenosis, bicuspid aortic valve, diabetes | AUTOIMMUNE DISEASES, MALIGNANT NEOPLASMS, INFECTIOUS ENDOCARDITIS, AORTIC VALVE INSUFFICIENCY, DISEASES, FIBRILLATION, DIABETES | This study included patients aged at least 65 years or older, with severe aortic
valve stenosis, with small aortic annulus (≤ 23 mm), and who underwent
isolated aortic valve replacement, divided into two groups - Group P, 12
patients with Perceval™ S valve (LivaNova), and Group C, 12 patients with
conventional bioprost... | PMC10610908 |
Sample Size | The sample size calculation for this study was based on the standard deviation
estimated in the study by Jansen et al.
Flowchart of the participants, according to the Consolidated
Standards of Reporting Trials (or CONSORT 2010). | PMC10610908 | ||
Ethical Aspects | The design of this study was approved by the ethics committee of the Instituto
Dante Pazzanese de Cardiologia (date 06/09/2016, CAAE number
56150516.5.0000.5462), and all patients signed an informed consent form. | PMC10610908 | ||
Surgical Technique | hypothermia | DECALCIFICATION | The surgical procedure was performed through median sternotomy, with cannulation
of the ascending aorta and right auricle, hypothermia (30°C), aortic
cross-clamping, blood cardioplegia, transverse aortotomy (in the case of the
Perceval™ prosthesis 1 cm above the sinotubular junction), removal of the
native aortic valve... | PMC10610908 |
Inflammatory Response | SIRS | PCT | The occurrence of severe SIRS was defined by the presence of three or more of the
following criteria during the first 48 hours after surgery: temperature <
36.0 or > 38°C, heart rate > 90 beats/minute, respiratory rate > 20
breaths/minute or PaCO₂ > 32 mmHg, and leukocyte count > 12 or < 4
(10The EMP release profile wa... | PMC10610908 |
Statistical Analysis | The means or medians and standard deviation or interquartile ranges were used for
continuous variables, and absolute and relative frequencies were used for
categorical variables. The variables were compared according to the type of
prosthesis using non-parametric hypothesis tests: Mann-Whitney U test for
continuous var... | PMC10610908 | ||
RESULTS | bleeding, SIRS, shock, stroke, paravalvular leak, neurological deficit, hypertrophy, stenosis | BLEEDING, SHOCK, STROKE, ACUTE RENAL FAILURE, HYPERTROPHY, HEART, STENOSIS, COMPLICATIONS | From September 4, 2018, to December 15, 2020, 24 patients with severe aortic valve
stenosis underwent aortic valve replacement surgery, 12 patients in the group C and
12 patients in the group P. Twenty (83.33%) patients were female, mean age was
69.92±5.17 years, and most patients were in New York Heart Association (NY... | PMC10610908 |
Laboratory Findings in the Preoperative and Postoperative Period of 24 Hours
and Three Months | MP | PCT | In the levels of EMP (MP CD31+, CD42b-, CD144+), there was a significant increase
in the 24-hour postoperative period (Comparisons of the mean effects of the conventional and Perceval™
groups over time (preoperative and 24-hour and 3-month postoperative)
with respect to laboratory variables.Comparisons between the conv... | PMC10610908 |
DISCUSSION | TAVI, SIRS, aortic valve stenosis, aortic stenosis, MP, stenosis, trauma | PCT, INFLAMMATION, AORTIC VALVE STENOSIS, AORTIC STENOSIS, STENOSIS, INFLAMMATORY RESPONSE | Studies report a high incidence of SIRS in the immediate postoperative period of
surgical valve replacement, and it is directly related to surgical trauma and the
use of CPBRegarding the effect of aortic stenosis treatment in the mid-term follow-up, a
prospective study in 56 symptomatic patients with significant aortic... | PMC10610908 |
Limitations | INFLAMMATORY RESPONSE | Our study was performed in a single center, and we did not evaluate the effect of
statins on the inflammatory response, but a study reports that statins
effectively inhibit the release of EMP | PMC10610908 | |
REFERENCES | PMC10610908 | |||
Background | The increasing integration of digital technologies into daily life has spurred a growing body of research in the field of digital psychology. This research has shed light on the potential benefits and drawbacks of digital technologies for mental health and well-being. However, the intricate relationship between technol... | PMC10617103 | ||
Purpose | anxiety | This study aimed to investigate the impact of mindfulness-based mobile apps on university students' anxiety, loneliness, and well-being. Additionally, it sought to explore participants' perceptions of the addictiveness of these apps. | PMC10617103 | |
Method | The research utilized a multi-phase approach, encompassing a correlational research method, a pretest–posttest randomized controlled trial, and a qualitative case study. Participants were segmented into three subsets: correlations ( | PMC10617103 | ||
Results | anxiety | The study uncovered a significant correlation between social media use and the variables under investigation. Moreover, the treatment involving mindfulness-based mobile apps led to a reduction in students' anxiety and an enhancement of their well-being. Notably, participants held various positive perceptions regarding ... | PMC10617103 | |
Implications | The findings of this research hold both theoretical and practical significance for the field of digital psychology. They provide insight into the potential of mindfulness-based mobile apps to positively impact university students' mental health and well-being. Additionally, the study underscores the need for further ex... | PMC10617103 | ||
Supplementary Information | The online version contains supplementary material available at 10.1186/s40359-023-01398-7. | PMC10617103 | ||
Keywords | PMC10617103 | |||
Introduction | human behavior, anxiety | The field of digital psychology is undergoing rapid evolution, navigating the intricate intersection of psychology and technology to elucidate the profound impact of digital technologies on human behavior, cognition, and emotions [The exploration of digital psychology has also delved into the impact of video games on c... | PMC10617103 | |
Review of literature | PMC10617103 | |||
Theoretical background | anxiety | The study investigating the effects of mindfulness-based mobile apps on university students' anxiety, loneliness, and well-being in the context of social media usage draws upon a multifaceted theoretical framework. At its core, it is rooted in mindfulness theory, which emphasizes present-moment awareness and non-judgme... | PMC10617103 | |
Social media and symptoms of mental health | anxiety | The use of social media has become increasingly prevalent among university students, and with it comes growing concern about its potential impact on mental health and well-being. Specifically, research has focused on the relationship between social media use and symptoms of social anxiety, loneliness, and well-being am... | PMC10617103 | |
Mindfulness-based apps effect mental health | depression, anxiety | Mindfulness-based mobile apps are becoming increasingly popular as a tool for promoting mental health and wellbeing. These apps include a variety of different mindfulness-based practices, such as guided meditations, breathing exercises, and other techniques aimed at reducing stress and anxiety. While there is growing e... | PMC10617103 | |
The use of technology for mental health support | The utilization of technology for the provision of mental health support has gained increasing prominence within the context of university students, prompting a burgeoning interest in comprehending their encounters and viewpoints. Related inquiries have been undertaken in diverse geographical regions, including the Uni... | PMC10617103 | ||
Methodology | PMC10617103 | |||
Design | anxiety | This was a multi-phase research design. In the first phase, a correlational research method was used for exploring the correlation among the research variables. In the second phase, we used a pretest–posttest randomized controlled trial to assess the effectiveness of a mindfulness-based mobile app intervention on sympt... | PMC10617103 | |
Participants | Participants for this study were selected from graduate students at Zhoukou Vocational and Technical College in China. Three separate groups were recruited for the study. The first group consisted of 300 participants who were recruited for a correlational study related to question 1. The eligibility criteria for this g... | PMC10617103 | ||
Measures | The following instruments were used to collect data for this study: | PMC10617103 | ||
Social Anxiety Scale for Adolescents (SAS-A) | anxiety | It is a 22-item self-report questionnaire that measures social anxiety in adolescents [ | PMC10617103 | |
Warwick-Edinburgh Mental Well-being Scale (WEMWBS) | It is a 14-item self-report questionnaire that measures mental well-being in adults and adolescents [ | PMC10617103 | ||
Social Media Use Integration Scale (SMUIS) | The SMUIS is a 10-item self-report questionnaire that assesses the frequency, duration and emotional connection to social media use [ | PMC10617103 | ||
Interview checklist | anxiety | The interview checklist consisted of 8 open-ended questions followed by the interviewer’s prompts. The questions elicited the interviewees’ perceptions of the benefits and challenges of using mobile apps for improving mental health and well-being and reducing social anxiety symptoms and loneliness (See Additional file | PMC10617103 | |
Mindfulness-based mobile apps | depression, anxiety | Mindfulness-based mobile apps are mobile applications designed to help individuals develop mindfulness skills and reduce symptoms of stress, anxiety, and depression. These apps typically include guided mindfulness exercises, educational resources, and other features to help individuals practice mindfulness on a regular... | PMC10617103 | |
Procedure | Depression | The study was conducted in multiple steps. Initially, a sample of 300 graduate students from Fudan University was selected to participate in the research. These participants were asked to complete the Social Media Use Integration Scale (SMUIS) and the Depression Anxiety Stress Scales (DASS-21) to evaluate their social ... | PMC10617103 | |
Data analysis | depression, Depression, anxiety | REGRESSION | For the quantitative data, the statistical software was employed. Firstly, descriptive statistics were calculated to determine the mean, and standard deviation of the Social Media Use Integration Scale (SMUIS) and Depression Anxiety Stress Scales (DASS-21) scores, as well as the mean, and standard deviation of the SMUI... | PMC10617103 |
Findings | PMC10617103 | |||
Research question 2 | ’ social anxiety, anxiety | The second research aimed at investigating the effects of the intervention on the students’ social anxiety, loneliness, and well-being. Results are presented in Table ANOVA test for comparing the groups’ pretests and posttestsThis table presents the results of a pretest–posttest randomized control-experimental research... | PMC10617103 | |
Research question 3 | depression, ’ social anxiety, anxiety | The third research question explored the students’ perceptions of the effects of mindfulness-based mobile apps on the students’ social anxiety, loneliness, and well-being. The detailed analysis of the interviews revealed 6 benefits and 4 challenges of using technology for mental health support. The first extracted bene... | PMC10617103 | |
Discussion | compulsive behavior, addiction and, anxiety | POSITIVE | The study investigating the effects of mindfulness-based mobile apps on university students' anxiety, loneliness, and well-being in the context of social media usage is anchored in a multifaceted theoretical framework. At its core, the research draws upon mindfulness theory, a foundational framework emphasizing present... | PMC10617103 |
Conclusions | anxiety | It can be concluded that the current findings add to the growing body of literature suggesting that social media use is linked to negative mental health outcomes. However, it is important to note that the causal direction of these relationships remains unclear. Although social media use may contribute to negative menta... | PMC10617103 | |
Acknowledgements | The authors would like to thank all participants. | PMC10617103 | ||
Author’s contribution | Li Sun designed the study. Li Sun collected the data. Li Sun analyzed and interpreted the data, drafted the manuscript, proofread the paper, and verified the submitted version. | PMC10617103 | ||
Funding | Phased Results of Key Projects of Vocational Education and Teaching Reform in Henan Province in 2021 (Project No.: Yujiao [2021] 57946). | PMC10617103 | ||
Availability of data and materials | The data will be made available upon request from the author ( email: sun894954@gmail.com). | PMC10617103 | ||
Declarations | PMC10617103 | |||
Ethics approval and consent to participate | The ethical approval committee of Zhoukou Vocational and Technical College approved this study and issued a letter (No. 2023.2623), indicating the study has no side effects on the participants of the study. All experiments were performed in accordance with relevant guidelines and regulations. All methods were carried o... | PMC10617103 | ||
Consent for publication | Not applicable. | PMC10617103 | ||
Competing interests | The authors declare no competing interests. | PMC10617103 | ||
References | PMC10617103 | |||
Background | ESPB | Perioperative analgesia is very important during an abdominal hysterectomy. Determining the impact of the erector spinae plane block (ESPB) on patients undergoing an open abdominal hysterectomy while under general anesthesia was our aim. | PMC10240679 | |
Methods | ESPB | In order to create equal groups, 100 patients who underwent elective open abdominal hysterectomies under general anesthesia were enlisted. The preoperative bilateral ESPB with 20 ml of bupivacaine 0.25% was administered to the ESPB group ( | PMC10240679 | |
Results | ESPB | We found that the mean (SD) intraoperative fentanyl consumption was significantly lower in the ESPB group than in the control group (82.9 (27.4) g vs. 148.5 (44.8) g, with a 95% CI = -80.3 to -50.8; We documented that during the post-operative period (0–24 h), VAS scores at rest were, on average, 1.03 units lower in th... | PMC10240679 | |
Conclusion | postoperative pain, ESPB | Bilateral ESPB can be utilized as an adjuvant method to reduce intraoperative fentanyl consumption and enhance postoperative pain control in patients undergoing open total abdominal hysterectomy under general anesthesia. It is effective, secure, and little obtrusive. | PMC10240679 | |
Trial registration | No protocol revisions or study amendments have been made since the trial's inception, according to the information on ClinicalTrials.gov (NCT05072184; principal investigator: Mohamed Ahmed Hamed; date of registration: October 28, 2021). | PMC10240679 | ||
Keywords | Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). | PMC10240679 | ||
Background | infections, ESPB | RESPIRATORY DEPRESSION, INFECTIONS, COAGULOPATHY, THROMBOEMBOLISM | In order to increase patient comfort, enable early mobilization, lower the risk of thromboembolism, and reduce the length of time patients must stay in the hospital after an abdominal hysterectomy, it is crucial to provide patients with adequate perioperative analgesia [Opioid-based analgesia is the standard of care, b... | PMC10240679 |
Methods | ESPB, bleeding, M546 | CHRONIC PAIN, BLEEDING, LOCALIZED INFECTION, DRUG ALLERGY | According to the principles of the Declaration of Helsinki, this prospective clinical trial was conducted as a randomized, triple blinded, parallel-group study. The study at Fayoum University Hospital (M546) received approval from the ethical review board, and participants' written agreement was obtained. After being r... | PMC10240679 |
Anesthesia and block procedure | ESPB, pain | BLOOD, HYPERTENSION, MUSCLE RELAXATION | Granisetron and dexamethasone were used to premedicate all patients prior to surgery. Using noninvasive methods such noninvasive electrocardiography, pulse oximetry, capnography, temperature monitoring, and bispectral index (BIS), all patients were observed in the operating room. A 22G, 50 mm block needle (SONOTAP, Paj... | PMC10240679 |
Measured parameters | cough, pain | SECONDARY, COMPLICATIONS | The total intra-operative fentanyl consumption (µg) was the primary outcome. The use of intraoperative sevoflurane (ml), postoperative fentanyl in the first 24 h (µg), systolic blood pressure, the mean VAS score at rest and with cough (score 0 = no pain and 10 = worst pain ever), any complications involving the block, ... | PMC10240679 |
Statistical analysis and sample size estimation | The sample size was calculated using G-Power software version 3.1.7 (Institute of Experimental Psychology, Heinrich Heine University, Dusseldorf, Germany). A minimum sample size of fifty patients was required for each group. Based on results from other studies [To enable data manipulation, data was gathered, coded, and... | PMC10240679 | ||
Discussion | obese, ESPB | OBESE | When comparing the intraoperative and postoperative doses of fentanyl in our clinical experiment, there is a statistically significant difference between the two groups, with the ESPB group consuming less of the fentanyl. However, there is no statistically significant difference between the groups in sevoflurane consum... | PMC10240679 |
Limitations | All of the clinical study participants were Egyptian, which restricted the data's applicability to people of other races. Fentanyl consumption and VAS scores were only evaluated during the trial's 24-h period. | PMC10240679 | ||
Conclusion | postoperative pain, ESPB | To reduce intraoperative fentanyl use and improve postoperative pain management in patients having open total abdominal hysterectomy under general anesthesia, bilateral ESPB is a safe, efficient, minimally invasive adjuvant technique. | PMC10240679 | |
Acknowledgements | Not applicable. | PMC10240679 | ||
Authors’ contributions | RECRUITMENT | Data collection: MAH, MLB,RAA Data analysis: MAH, MLB,RAA,MAM Writing: MAH,RAA,MAM. Revising: MAH, MLB,RAA,MAM. Study design: MAH, MLB,RAA. Patient recruitment: MAH. All authors contributed equally to this work. Corresponding author and the guarantor: MAH. The author(s) read and approved the final manuscript. | PMC10240679 | |
Funding | Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). The authors have no sources of funding to declare for this manuscript. | PMC10240679 |
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