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Biodegradable magnesium screws are self-degrading in vivo | Magnesium ions are absorbed to form new bone in human body [ | PMC10363316 | ||
Advantages of DCE-MRI in assessing blood supply and the role of magnesium screws in promoting angiogenesis | necrotic, hypertrophy, femoral osteonecrosis, occlusion of blood vessels, non-traumatic osteonecrosis | GROUP B, VASCULARIZATION, OSTEONECROSIS, NECROTIC, HYPERTROPHY, NEOVASCULARIZATION, PATHOGENESIS | The pathogenesis of non-traumatic osteonecrosis remains unknown; however, alterations in intramedullary circulation are known to play a role. Narrowing or occlusion of blood vessels within the femoral head is a direct cause of non-traumatic femoral osteonecrosis. For example, in patients with hormone-induced osteonecro... | PMC10363316 |
Limitations and next plan of this study | Several limitations were identified in this study. Firstly, the sample size of 36 patients was relatively small and may not have provided sufficient statistical power. Secondly, although local pneumatization has been reported in the literature as a potential risk of magnesium screw implantation, we did not observe this... | PMC10363316 | ||
Conclusions | Our study determined that PVIBGT effectively improved blood supply to the femoral head. We propose that biodegradable magnesium screws offer two primary advantages compared to other methods. Firstly, when compared to the direct embedding method, biodegradable magnesium screws provide better fixation and reduce the risk... | PMC10363316 | ||
Acknowledgements | ONFH | The translational potential of this article: This paper reports on a biodegradable magnesium screw, which is biodegradable and promote angiogenesis in PVIBGT. Biodegradable magnesium screws can become promising internal fixation screws for ONFH. | PMC10363316 | |
Author contributions | Tianwei Xia and Jiahao Sun contributed equally to this work. Tianwei Xia and Jiahao Sun analysed and interpreted the data and wrote the draft. Shaowei Liu was responsible for rediological examinations (including X-ray, CT, DCE-MRI). Jiahao Sun collected the data, and finished the statistical work of data. Jiahao Sun ma... | PMC10363316 | ||
Funding | This study was funded by the National Natural Science Foundation of China (Grant No. 82274552) and Clinical Trial Project Foundation of Dongguan Eontec. Co., Ltd. and Affiliated Hospital of Nanjing University of Chinese Medicine (Grant No. JSSZGCP2020-22). | PMC10363316 | ||
Availability of data and materials | The datasets used during the current study are available from the corresponding author on reasonable request. | PMC10363316 | ||
Declarations | PMC10363316 | |||
Ethics approval and consent to participate | After providing all the enrolled patients with detailed information about the surgical procedure, their written informed consent was obtained. All procedures are carried out in accordance with the “Helsinki Declaration” of the World Medical Association. The study was approved by the Medical Ethics Committee of Affiliat... | PMC10363316 | ||
Consents for publication | Not applicable. | PMC10363316 | ||
Competing interests | The authors declare no competing interests. | PMC10363316 | ||
References | PMC10363316 | |||
Background | The LIMIT randomised controlled trial looked at the effect of a dietary and lifestyle intervention compared with routine antenatal care for pregnant women with overweight and obesity on pregnancy outcomes. While women in the intervention group improved diet and physical activity with a reduction of high birth weight, o... | PMC10729523 | ||
Methods | Children at 8–10 years of age who were born to women who participated in the LIMIT randomised trial, and whose mother provided consent to ongoing follow-up were eligible for inclusion. The primary study endpoint was the incidence of child BMI z-score > 85th centile for child sex and age. Secondary study outcomes includ... | PMC10729523 | ||
Results | SECONDARY | We assessed 1,015 (Lifestyle Advice n = 510; Standard Care n = 505) (48%) of the 2,121 eligible children. BMI z-score > 85th percentile was similar for children of women in the dietary Lifestyle Advice Group compared with children of women in the Standard Care Group (Lifestyle Advice 479 (45%) versus Standard Care 507 ... | PMC10729523 | |
Conclusions | obesity | OBESITY, CHILDHOOD OBESITY | Dietary and lifestyle advice for women with overweight and obesity in pregnancy has not reduced the risk of childhood obesity, with children remaining at risk of adolescent and adult obesity. Other strategies are needed to address the risk of overweight and obesity in children including investigation of preconception i... | PMC10729523 |
Supplementary Information | The online version contains supplementary material available at 10.1186/s12887-023-04466-4. | PMC10729523 | ||
Keywords | PMC10729523 | |||
Introduction | CHILDHOOD OBESITY | Childhood obesity is recognised as a significant global health issue, conservatively estimated to affect more than 340 million children and adolescents [Approximately 50% of women in Australia commence pregnancy with a BMI above the healthy range [The findings of the LIMIT trial have been confirmed by the UPBEAT trial ... | PMC10729523 | |
Methods | MAY, SECONDARY, ARTERIAL STIFFNESS, BLOOD | The LIMIT randomised controlled trial was registered with the Australian and New Zealand Clinical Trials Registry (ACTRN12607000161426), with the methods and clinical outcomes reported previously [Following ethics approval and parental written consent, we conducted follow-up of children born to women who participated i... | PMC10729523 | |
Sample size | The available sample size of children at 8 to 10 years of age was predetermined by the LIMIT trial, with a total of 2,212 women randomized [ | PMC10729523 | ||
Statistical analysis | REGRESSION, EARLY PREGNANCY | Data were analysed using intention to treat principles, according to the treatment group to which the woman was randomised in pregnancy. Missing data were imputed using the fully conditional specification (chained equations) method to create 100 complete datasets under the assumption that the data were missing at rando... | PMC10729523 | |
Discussion | obesity | OBESITY, CHILDHOOD OBESITY, EARLY PREGNANCY | This current study has shown that there were no differences in any anthropometric or behavioural measures of the 8–10 year old children born to women participating in the LIMIT Trial. However the children remain at high risk of childhood obesity with more than 45% of the entire cohort having a BMI above the 85th percen... | PMC10729523 |
Conclusions | obesity | OBESITY, CHILDHOOD OBESITY | The findings of this 8–10 year follow up of children from the LIMIT Trial show that the risk of childhood obesity whilst high, was not modified by a dietary and lifestyle intervention in pregnancy. This is further evidence that a continued focus on pregnancy interventions to interrupt the transmission of intergeneratio... | PMC10729523 |
Acknowledgements | We are indebted to the 2 212 women who participated in the LIMIT randomised trial, and to the 1 105 children who contributed to the 8–10 year outcome data. The following persons in Adelaide, South Australia participated in the conduct of the 8–10 year Follow-up of LIMIT Trial: Co-ordinating Team—JMD, ARD, JL, MM, APV, ... | PMC10729523 | ||
Author contributions | MM | JMD, ARD and JL designed and supervised the study including data collection. JL curated and analysed the study data. JMD, JL, ARD, MM and ASV interpreted the data. JMD and ARD drafted the manuscript. All authors reviewed, edited and approved the final verson of the manuscript. | PMC10729523 | |
Funding | This study was funded by a NHMRC Project Grant (APP1159338). JMD is supported by a NHMRC Investigator Grant (APP1196133). | PMC10729523 | ||
Data Availability | The data reported are available on request as the unrestricted access, including de-identified, is not supported by the local ethics committee. Data access requests can be made to the LIMIT Study Steering Committee via the corresponding author, Professor Jodie Dodd, University of Adelaide, WCH Campus, 72 King William S... | PMC10729523 | ||
Declarations | PMC10729523 | |||
Ethics approval and consent to participate | This study was performed in accordance with the Declaration of Helsinki, and was reviewed and approved by the Women’s and Children’s Health Network Human Research Ethics Committee (HREC/18WCHN/165). Women who participated in the LIMIT trial gave written informed consent for their child to participate in the follow-up s... | PMC10729523 | ||
Consent for publication | Not applicable. | PMC10729523 | ||
Competing interests | The authors declare no competing interests. | PMC10729523 | ||
Abbreviations | Adjusted relative riskAdjusted mean differenceBody mass indexChild Behaviour ChecklistConfidence intervalChildren’s Leisure Activity Study SurveyGestational weight gainMissing at randomMetabolic equivalent taskMissing not at randomNational Assessment Program – Language and NumeracyStandard deviationSocio-economic index... | PMC10729523 | ||
References | PMC10729523 | |||
Background | Regarding the care of older adults, 24-h home-care represents a cornerstone, with > 32,000 service users in Austria. Our research project | PMC10655364 | ||
Methods | The application used in our study comprises an e-learning platform, an integrated emergency management, networking opportunities, and an electronic care documentation system in the native language of the 24h-caregivers. The trial was conducted using a parallel three-arm study design to evaluate (i) a control group, whi... | PMC10655364 | ||
Results | Among the 110 24h-caregivers who were randomly classified into the three groups, | PMC10655364 | ||
Conclusions | Providing e-learning and e-documentation devices to 24h-caregivers improved their care-related quality of life, mainly because they felt more encouraged and supported. Moreover, these interventions improved their self-perceived professional skills. As an extrapolation of findings, we found that these interventions coul... | PMC10655364 | ||
Trial registration | Digital Support for Quality Assurance in 24-h Caregiving at Home was registered and posted on the ClinicalTrials.gov public website (ClinicalTrials.gov Identifier: NCT04581538). | PMC10655364 | ||
Supplementary Information | The online version contains supplementary material available at 10.1186/s12877-023-04454-4. | PMC10655364 | ||
Keywords | PMC10655364 | |||
Background | Owing to demographic changes, the demand for professional and institutional care, as well as 24-h home care is increasing worldwide. In several European countries, migrant care work in private households has become an important, but often illegal, source of long-term care provision. The 24-h home care reform in Austria... | PMC10655364 | ||
Methods | PMC10655364 | |||
Trial design, setting, and participants | death | The present study followed a parallel three-arm study design in which the households were evenly distributed. The three parallel arms evaluated a (i) control group, who continued usual home care (including unstructured paper–pencil documentation), (ii) a partial intervention group, which used e-learning and networking ... | PMC10655364 | |
Stratified randomization and recruitment | Stratified randomization was applied based on the care receiver’s care level and 24h-caregiver’s professional experience (see scoring scheme in Supplementary Table SParticipants were recruited by four project partner organizations, namely All 24h-caregivers provided written informed consent before participation. Ethica... | PMC10655364 | ||
Interventions | Based on the results of a qualitative requirements study, emergency management skills and information about common geriatric conditions and legal aspects of 24-h care were identified as the main needs of the 24h-caregivers [The intervention was administered via a device (a tablet with the client–server software solutio... | PMC10655364 | ||
Outcome measures | The primary prespecified outcome measure used in this study was the metric For sample characterization, the following baseline characteristics were collected: for care receivers: (i) age (metric), (ii) sex (nominal), and (iii) care level (ordinal); and for 24h-caregivers: (iv) age (metric), (v) professional home-care e... | PMC10655364 | ||
Statistical methods | Survey responses were analyzed in the statistical software SPSS version 27 (IBM Corp., 2021 Armonk, NY). Planned comparisons were conducted between the control group and any intervention group (contrast 1) and between the partial and full intervention groups, which additionally used the digital nursing documentation (c... | PMC10655364 | ||
Results | PMC10655364 | |||
ASCOT | Data analysis revealed some extent of baseline imbalance in the means of the outcome variable ASCOT score trend | PMC10655364 | ||
Follow-up 1 | At 5 months, baseline imbalance corrected means did not significantly differ among the three groups [F(2) = 2.25, | PMC10655364 | ||
Follow-up 2 | At 9 months, baseline imbalance corrected means did not differ significantly among the three groups [F(2) = 2.76, | PMC10655364 | ||
Efficacy survey | Consistent with the Efficacy score trends | PMC10655364 | ||
Follow-up 1 | At 5 months, baseline imbalance corrected means did not differ significantly among the three groups [F(2) = 0.42, | PMC10655364 | ||
Follow-up 2 | At 9 months, baseline imbalance corrected means differed significantly among the three groups [F(2) = 3.96, Additional explorative ANCOVA analyses accounting for the nested data structure (when two 24h-caregivers worked consecutively in the same household) of the | PMC10655364 | ||
Discussion | Our research project In the present study, we observed a trend toward improved social care-related quality of life and project-specific items on self-perceived professional skills, feeling competent, and social/professional interaction. In an extrapolation of these findings to burden, they support the trend toward redu... | PMC10655364 | ||
Limitations | This study reported results of interventions addressing the quality of life and self-perceived professional skills of 24h-caregivers. The trial was designed to primarily examine the | PMC10655364 | ||
Conclusions | professional/communicational skills | Providing e-learning and e-documentation devices to 24h-caregivers improved their social care-related quality of life, mainly because they felt more encouraged and supported. Moreover, the interventions led to improved self-perceived professional/communication skills, satisfaction with the documentation used, and readi... | PMC10655364 | |
Acknowledgements | RECRUITMENT | Special thanks go to the participating 24h-caregivers and to the clients who shared their valuable experiences. Furthermore, we would like to acknowledge the contribution of the project partners involved in the recruitment and enrollment processes. Moreover, we thank Mr. Sebastian Durstberger for running the post-hoc p... | PMC10655364 | |
Authors’ contributions | All authors contributed to the design, conduct, and interpretation of the study. EHB and PP prepared the first draft of the manuscript. | PMC10655364 | ||
Funding | The research project 24h QuAALity was funded by the Austrian Research Promotion Agency (FFG), grant number (FFG project number) 868222. A project description by the funding organization is available online: | PMC10655364 | ||
Availability of data and materials | The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request. | PMC10655364 | ||
Declarations | PMC10655364 | |||
Ethics approval and consent to participate | The trial was performed in accordance with the Declaration of Helsinki. Ethical approval was obtained from the Ethics Committee of the Evangelical Hospital Vienna, Austria (approval number: 012019). All participants provided written consent to participate in this study. | PMC10655364 | ||
Consent for publication | This manuscript does not contain any individual person’s data in any form. | PMC10655364 | ||
Competing interests | The authors declare no competing interests. | PMC10655364 | ||
References | PMC10655364 | |||
Background | Aphthous Stomatitis | APHTHOUS STOMATITIS, DISEASE | Recurrent Aphthous Stomatitis (RAS) is one of the most common lesions of the oral mucosa. Herbal medicine can be used for the treatment of this disease. The present study aimed to compare the effects of topical application of Sage (Salvizan) and triamcinolone acetonide gels on RAS. | PMC10024424 |
Methods | Pain, pain | APHTHOUS ULCERS, REGRESSION, MINOR | This double-blind clinical study recruited sixty patients with minor aphthous ulcers. Half of the patients were treated with Salvizan gel, and the other half were treated with oral triamcinolone acetonide gel. The effect of Salvizan topical gel was evaluated and compared with that of oral triamcinolone acetonide gel. F... | PMC10024424 |
Results | pain | The mean duration of pain recovery was 1.5 days for Salvizan and 2.5 days for triamcinolone acetonide ( | PMC10024424 | |
Conclusion | pain | DISEASES | The results of this study showed that Salvizan gel is very effective in the treatment of RAS. It was significantly better than triamcinolone acetonide in the pain recovery and wound healing. These promising results favor herbal treatments and show that they can be used more commonly for treating diseases such as RAS. | PMC10024424 |
Trial registration | This study was approved by the ethics committee of Isfahan University of Medical Sciences (IR.MUI.RESEARCH.REC.1399.834) on 17/03/2021. It was also registered in the Iranian Registry of Clinical Trials (IRCT20100202003251N7). | PMC10024424 | ||
Keywords | PMC10024424 | |||
Background | infectious diseases, allergic, inflammation, traumatic, pain, Aphthous Stomatitis | INFECTIOUS DISEASES, ORAL LICHENOID REACTION, STILL, MUCOSA DISEASE, INFLAMMATION, DISEASE, ULCERS, APHTHOUS STOMATITIS, CAVITY, MINOR ORAL APHTHOUS ULCER | Recurrent Aphthous Stomatitis (RAS) is a common oral mucosa disease characterized by single or multiple painful and recurrent ulcers confined to the oral cavity. Its prevalence in different populations has been reported to vary from 5 to 50%, with an average prevalence rate of 20% and higher occurrence in young women [... | PMC10024424 |
Methods | PMC10024424 | |||
Study design and ethical approvement | MAY | This study was approved by the ethics committee of Isfahan University of Medical Sciences (IR.MUI.RESEARCH.REC.1399.834) on March 17th, 2021. All methods were performed in accordance with the relevant guidelines and regulations. It was a double-blind, randomized clinical trial conducted from May to June 2021. The study... | PMC10024424 | |
Patient selection | herpetiform, allergy, Triadent®, blindness | SYSTEMIC DISEASE, BLINDNESS, ALLERGY, BLIND, APHTHOUS ULCERS | This study was performed in the Dentistry school of the Medical University of Isfahan. Patients with confirmed RAS aged 18–50 were included in this study. Exclusion criteria were pregnant or lactating women, history of allergy to herbal products, history of a systemic disease, history of using anti-inflammatory or cort... | PMC10024424 |
Treatment process | aphthous, ulcer, pain | APHTHOUS ULCERS, MAY, ULCER | Patients were instructed on how to take the drug. Then they were asked to show the process to be sure they understood the instructions correctly. It was topically applied to aphthous ulcers three times a day using a swab as much as 1 cm, preferably after eating and mouth rinsing. After applying the drug, the patient wa... | PMC10024424 |
Statistical analysis | REGRESSION | All data were fed into SPSS version 26 (software from IBM corp.) and analyzed by independent t-test, paired t-test, ANOVA for repeated measures, and survival analysis, including Kaplan-Meier and Cox regression. A significant level of | PMC10024424 | |
Results | pain | Among those referred to the designated center, 75 eligible patients were recruited for the study with full consent. Fifteen patients left the study for reasons such as being far away from the dentistry school (3 patients) and unwillingness to continue the treatment (12 patients). So, the study was performed with 60 pat... | PMC10024424 | |
Discussion | aphthous ulcers, pain | APHTHOUS ULCERS, DISEASES, RECURRENT APHTHOUS STOMATITIS, RECURRENT APHTHOUS ULCER | The present study showed promising results in treating RAS with Salvizan gel containing an extract of Sage. Compared to Triamcinolone acetonide, Salvizan gel performed better in both reducing the pain recovery and wound healing (complete recovery) times. Recurrent aphthous stomatitis is one of the most common oral dise... | PMC10024424 |
Acknowledgements | We acknowledge Dr. Atefe Tavangar from the department of oral and maxillofacial medicine, who supported this study. | PMC10024424 | ||
Authors’ contributions | FA designed the study, performed instructions for the patients, and supervised all study steps, including patient selection, treatment process, follow-ups, gathering and analyzing the data, and writing the manuscript. ZR was in charge of the enrollment of the patients, treatment process, and follow-ups. AY checked the ... | PMC10024424 | ||
Funding | This study was funded by Medical University of Isfahan. This paper is originated from the DDS degree thesis of Zeinab Rasoulzadeh. | PMC10024424 | ||
Data availability | The data gathered and analyzed in the current study are kept private due to the preference of the authors but will be available from the corresponding author on reasonable requests. | PMC10024424 | ||
Declarations | PMC10024424 | |||
Ethics approval and consent to participate | This study was approved by the ethics committee of Isfahan University of Medical Sciences (IR.MUI.RESEARCH.REC.1399.834) on 17/03/2021. All methods were performed in accordance with the relevant guidelines and regulations. It was also registered in the Iranian Registry of Clinical Trials (IRCT20100202003251N7) on 13/10... | PMC10024424 | ||
Consent for publication | Not applicable. | PMC10024424 | ||
Competing interests | The authors declare that they have no competing interests. | PMC10024424 | ||
List of abbreviations | Aphthous Stomatitis | APHTHOUS STOMATITIS | Recurrent Aphthous Stomatitis | PMC10024424 |
References | PMC10024424 | |||
Background | fibroids, gynaecologische | FIBROIDS | No support from any organization for the submitted work was received, apart from the grant that was received from The Dutch organisation for Health Research and Development (ZonMW), as described in our funding statement; HvV received fees from Medtronic on an hourly basis for consultancy and lecturing on hysteroscopic ... | PMC10754450 |
Methods and findings | uterine fibroid, fibroid, clotting disorders, blood loss, pain, fibroids | UTERINE FIBROID, FIBROID, CLOTTING DISORDERS, BLOOD LOSS, FIBROIDS, SEVERE ANEMIA, COMPLICATIONS | This was a multicenter, randomized controlled noninferiority trial conducted in 14 university and teaching hospitals in the Netherlands between 2016 and 2021. Inclusion criteria were age ≥18 years, maximum number of 3 type 0 or 1 fibroids, maximum fibroid diameter 3.5 cm, American Society of Anesthesiologists class 1 o... | PMC10754450 |
Conclusions | fibroids | FIBROIDS | Noninferiority of PSA for completeness of resection was not shown, though there were no significant differences in clinical outcomes and quality of life. In this study, hysteroscopic myomectomy for type 0 and 1 fibroids with PSA compared to GA was safe and led to shorter hospitalization. These results can be used for c... | PMC10754450 |
Trial registration | fibroids, Julia van der Meulen | FIBROIDS | The study was registered prospectively in the Dutch Trial Register (Julia van der Meulen and co-workers compare procedural sedation and analgesia versus general anesthesia in women undergoing hysteroscopic myomectomy for fibroids. | PMC10754450 |
Author summary | PMC10754450 | |||
Why was this study done? | fibroids | FIBROIDS | ➢ Hysteroscopic myomectomy is the standard treatment for type 0 and 1 fibroids and is traditionally performed with general anesthesia (GA).➢ Procedural sedation and analgesia (PSA) is increasingly used in gynecologic surgery.➢ The use of PSA for hysteroscopic myomectomy compared to GA in terms of efficacy and safety ha... | PMC10754450 |
What did the researchers do and find? | blood loss | BLOOD LOSS, COMPLICATIONS | ➢ A randomized controlled noninferiority trial was performed comparing the use of PSA with GA for hysteroscopic myomectomy. Primary outcome was completeness of resection.➢ Noninferiority of PSA versus GA for completeness of resection could not be demonstrated.➢ We found no significant differences in complications, reco... | PMC10754450 |
What do these findings mean? | ➢ Hysteroscopic myomectomy can be performed under PSA in an outpatient setting.➢ These findings should help clinicians in counseling women undergoing hysteroscopic myomectomy. | PMC10754450 |
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