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Results | psychiatric | Greater severity in the psychiatric composite score was associated with substantially lower HRQoL, across all measures, following release from incarceration. Greater severity in the medical composite score was associated with lower pain/discomfort-related HRQoL. | PMC10210389 | |
Conclusions | OUD | Our findings highlight the importance of ensuring individuals with OUD are linked not only to MOUD, but also treatment for their comorbid conditions upon release from incarceration. | PMC10210389 | |
Supplementary Information | The online version contains supplementary material available at 10.1186/s13722-023-00375-0. | PMC10210389 | ||
Introduction | OUD, overdose | The U.S. Department of Justice estimated the number of incarcerated individuals under state and federal jurisdiction to be 1,430,800 at the end of 2019 [Initiation on OUD pharmacotherapy just prior-to, or immediately-following release from incarceration has been associated with increased rates of entry to community-bas... | PMC10210389 | |
Methods | PMC10210389 | |||
Study design and data | allergic, anxiety/depression, OUD, psychosis, abscess, depressive, psychiatric | ACTIVE TUBERCULOSIS, ABSCESS, ADVERSE EFFECTS, SECONDARY, CHRONIC PAIN, SEIZURE DISORDER | We conducted a secondary analysis of HRQoL among persons with OUD who were transitioning from incarceration to the community. Our analysis focused on the determinants of specific EQ-5D HRQoL domains, as well as the overall preference/utility score (please see description in Introduction), over the first 12 weeks post-r... | PMC10210389 |
Analysis | anxiety/depression | REGRESSION | Separate, multivariable regression models were run for the three HRQoL domains with sufficient variation (mobility, pain/discomfort, anxiety/depression), and the overall utility score, between baseline (pre-release) and 12 weeks post-release; all covariates mentioned above were included in each regression model. Ordina... | PMC10210389 |
Addressing missing data | The study was subject to significant patient attrition. Prior analyses of the parent study data concluded that data was missing at random (MAR), and employed robust methods such as multiple imputation, to avoid bias [ | PMC10210389 | ||
Results | PMC10210389 | |||
Significance between HRQOL domains and predictor variables | psychiatric | REGRESSION, REGRESSION | Table Multivariable Regression ResultsThe first 3 HRQoL Domains were analyzed using ordinal logistic regression and the HRQoL utility score was analyzed using OLS. IDU denoted injection drug use. Bolded values denotes statistical significance.Pain/discomfort was significantly associated with ASI medical (OR = 0.77; p <... | PMC10210389 |
Discussion | psychiatric illness, psychiatric, OUD, anxiety/depression | DISORDER, CHRONIC PAIN, APPENDIX, COMPLICATIONS | Increased psychiatric complications, as measured by the ASI, were strongly associated with reduced HRQoL scores over the period immediately following incarceration, in all domains explored (mobility, anxiety/depression, pain/discomfort), as well as a relatively large decrease in overall utility. Although the ASI does n... | PMC10210389 |
Conclusion | psychiatric, OUD | DISORDERS | Our findings highlight the importance of ensuring individuals with OUD are linked not only to MOUD, but also treatment for their comorbid conditions, particularly mental health disorders, upon release from incarceration. A holistic treatment approach for these individuals may be especially beneficial, given the estimat... | PMC10210389 |
Acknowledgements | Not applicable. | PMC10210389 | ||
Author contributions | TC and SMM conceived of the study. TC had access to the study data, and conducted the statistical analysis. TC, SMM, AJ, and PJJ interpreted the results. TC wrote the manuscript first draft. All authors contributed to and approved the final manuscript. All authors read and approved the final manuscript. | PMC10210389 | ||
Funding | ABUSE | Grants R01DA046721, and P30DA040500 from the National Institute on Drug Abuse (NIDA) of the National Institutes of Health (NIH). | PMC10210389 | |
Availability of data and materials | ABUSE | Statistical code: Available from Ms. Cadet (e-mail, tec4002@med.cornell.edu). Data set: Available in accordance with NIDA National Drug Abuse Treatment Clinical Trials Network policy ( | PMC10210389 | |
Declarations | PMC10210389 | |||
Ethics approval and consent to participate | Not applicable. | PMC10210389 | ||
Consent for publication | Not applicable. | PMC10210389 | ||
Competing interests | No competing interests to declare. Clinical trial registration: NCT02617628. | PMC10210389 | ||
References | PMC10210389 | |||
Purpose | This in vivo study aims to assess the pink esthetic score in the anterior maxilla after computer-guided immediate implant installation and fully digital immediate temporalization with and without grafting the jumping gap with a mixture of 1:1 autogenous and xenograft particulates. | PMC10644537 | ||
Materials and methods | upper anterior teeth, tooth, traumatic | Twenty-four patients with non-restorable upper anterior teeth in the aesthetic zone have undergone a traumatic extraction for the non-restorable tooth followed by immediate implant placement using a 3D-printed surgical guide according to prosthetically driven implant placement. The patients were divided into two groups... | PMC10644537 | |
Results | PES | Immediately postoperatively, there was no statistically significant difference between the median PES in the two groups (P-value = 0.746). After six months, the study group showed a statistically significantly higher median PES than the control group (P-value = 0.048). | PMC10644537 | |
Conclusions | Grafting the jumping distance in the immediate implant protocol helps achieve a better esthetic outcome. | PMC10644537 | ||
Clinical relevance | The use of immediate guided implant placement along with grafting the jumping gap followed by immediate digital temporalization guarantees a better esthetic outcome while preserving time, cost, and the number of clinical visits. | PMC10644537 | ||
Trial registration | The study was registered on clinicaltrials.gov with registration number NCT04096209. (19/9/2019) | PMC10644537 | ||
Keywords | Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). | PMC10644537 | ||
Introduction | angulation, bone loss, tooth | COMPLICATIONS, BONE LOSS | One of the main goals that modern dentistry strives to achieve is the successful and predictable restoration of missing teeth. Many materials and treatment modalities have been introduced for tooth replacement in the esthetic zone. The introduction of dental implants has brought this goal closer, leading to a revolutio... | PMC10644537 |
Materials and methods | upper anterior teeth, maxillary incisors, tooth | DIABETES MELLITUS, BONE DISEASES, DISEASES | The present parallel randomized control study was conducted following the ethical principles of the Helsinki Declaration for research on human subjects and was approved by the research ethics committee, faculty of dentistry, Cairo University (19)-(7)-(4). The study was registered on clinicaltrials.gov with registration... | PMC10644537 |
Designing surgical guides and temporary restorations | bite, CAD, STL | CAD | A Cone-Beam Computed Tomography x-ray (PaX-i3D Green; VATECH), with parameters of 120 kVp,37.07 MAs, and a 0.25 mm voxel size, was performed for each patient to obtain Digital Imaging and Communication in Medicine (DICOM) file. Intraoral scanning for both working and opposing arches, along with digital bite registratio... | PMC10644537 |
Implant placement | tooth | Atraumatic extraction of the tooth or remaining root using a No. 15c lancet and periotome to cut gingival fibers of periodontal ligaments was performed. In one case, we encountered a fractured root at the apical 1/3, where we carefully separated the root with a surgical bur mesiodistally (Cat eye slit technique) and re... | PMC10644537 | |
Pickup of the 3D-printed provisional restorations | Denture | The loading of the temporary abutments was carried out over the implants. Teflon was applied around the implant into the gingival sulcus to prevent the escape of any pickup material. The pickup of the 3D provisional crowns was done with self-cured acrylic resin (Denture Base Material; Vertex-Dental B.V.).The provisiona... | PMC10644537 | |
Grouping | PMC10644537 | |||
Group I. (the intervention group) | Patients were treated with immediate implant placement with a mixture of 50% Xenograft bone (Geistlich Bio-Oss®; Pharma AG, Bahnhofstrasse 40 CH -Wolhusen) and 50% autogenous bone placed in the jumping distance till the soft tissue level. The provisional restoration that was previously picked up is then screwed in plac... | PMC10644537 | ||
Group II. (the control group) | Patients were treated with conventional implant placement without grafting the jumping gap, followed by hand tightening of the provisional restoration. (Fig.
Immediate implant placement without grafting the jumping gap in the control groupAll patients received postoperative antibiotics orally for 3 days. Patients were... | PMC10644537 | ||
Pink esthetic evaluation | tooth [, PES, tooth | The Pink Esthetic Score (PES) is based on seven variables: distal papilla, mesial papilla, soft tissue contour, soft tissue level, deficiency of the alveolar process, and soft-tissue texture and color. Each variable was assessed with a 0-1-2 score, with 0 being the worst and 2 being the best. The mesial and distal papi... | PMC10644537 | |
Statistical methodology | Numerical data were explored for normality by checking the distribution of data and using tests of normality (Kolmogorov-Smirnov and Shapiro-Wilk tests). The Pink Esthetic Score data showed a non-parametric distribution. Data were presented as mean, standard deviation (SD), 95% confidence interval for the mean (95% CI)... | PMC10644537 | ||
Results | PMC10644537 | |||
Demographic data | Regarding baseline demographic data; there was no statistically significant difference between mean age values in the two groups. There was also no statistically significant difference between the gender distributions in the two groups. The mean and standard deviation (SD) values for age in the study group were 30.5 (9... | PMC10644537 | ||
Pink esthetic score comparison between the two groups (inter-group comparison) | PES | Immediately post-operatively, there was no statistically significant difference between the median PES in the two groups (P-value = 0.746, effect size = 0.13). After six months, the study group showed a statistically significantly higher median PES than the control group (P-value = 0.048, effect size = 0.859). Table
D... | PMC10644537 | |
Pink esthetic score changes within each group (intra-group comparison) | PES | In the study group, there was a statistically significant increase in PES after six months (P-value = 0.039, effect size = 0.596). In the control group, there was a statistically significant decrease in PES after six months (P-value = 0.035, effect size = 0.609). Table
Descriptive statistics and results of Wilcoxon si... | PMC10644537 | |
Discussion | angulation, PES, tooth | COLLAPSE, CREST | Many treatment protocols and materials are available to replace a natural tooth immediately after extraction, but the best protocol is unclear, especially in the esthetic zone [The relationship between the time of implant placement and the time of extraction can be classified into delayed placement after complete bone ... | PMC10644537 |
Conclusions | Within the limitations of the presented study, the following could be concluded:1-Computer-guided immediate implant placement with immediate temporalization using digitally designed infra-occlusal provisional restoration is a viable option for immediate implant replacement in the esthetic zone.2-The socket is an ideal ... | PMC10644537 | ||
Acknowledgements | The authors thank Professor Hussien El Charkawi (head of the prosthodontics department) for his valuable advice throughout conducting this research. | PMC10644537 | ||
Authors’ contributions | Sherine Osama El Ebiary (article approval, operator in all the practical work, manuscript Writing-concept- data collection). Mohammed Atef (concept- design-interpretation -data collection. Medhat Sameh Abdelaziz (Corresponding Author, writing of the manuscript-design- interpretation -software- article approval). Mohamm... | PMC10644537 | ||
Funding | This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.Open access funding provided by The Science, Technology & Innovation Funding Authority (STDF) in cooperation with The Egyptian Knowledge Bank (EKB). | PMC10644537 | ||
Data Availability | All data generated or analyzed during the current study are included in this published article and its additional files. | PMC10644537 | ||
Declarations | PMC10644537 | |||
Ethics approval and consent to participants | The present study followed the Declaration of Helsinki for the ethical principles of medical research involving human subjects and was approved by the faculty of dentistry, Cairo University (19)-(7)-(4). Informed consent was obtained from all subjects and/or their legal guardians. | PMC10644537 | ||
Consent for publication | Not Applicable. | PMC10644537 | ||
Competing interests | The authors declare no competing interests. | PMC10644537 | ||
References | PMC10644537 | |||
Abstract | PMC10726803 | |||
Objectives | depression, acute stroke | ACUTE STROKE | To date, the effectiveness of acceptance and commitment therapy (ACT) for acute stroke patients has not been well recognized. The study aimed to discover the effectiveness of group‐based ACT in treating depression for acute stroke patients. | PMC10726803 |
Methods | depression, 140 acute stroke | We conducted a randomized controlled trial with 140 acute stroke patients with depression. The ACT intervention comprised seven sessions, of 45–60 min over 4 weeks. Data were collected pre‐ and post‐intervention and at 3‐month follow‐up, assessing depression, health‐related quality of life (HRQoL), psychological flexib... | PMC10726803 | |
Results | depression, acute stroke | ACUTE STROKE | Overall, 99.3% of the included patients were assessed as having mild depression. The ACT intervention significantly reduced depression in acute stroke patients in comparison with the control group post‐intervention and at 3 months (partial | PMC10726803 |
Conclusions | depression, acute stroke, depressive symptoms | ACUTE STROKE | ACT is effective in treating acute stroke patients with depression, and the efficacy was maintained at 3‐month follow‐up.This study found that G‐ACT could significantly reduce depressive symptoms in patients with acute stroke, and the interventional efficacy was maintained at 3‐month follow‐up (partial Ƞ2 for this effe... | PMC10726803 |
INTRODUCTION | stroke, depression, acute stroke, depressive symptoms | STROKE, ACUTE STROKE | Expenditure on health care and mental health care is growing and posing serious challenges for governments around the world (Patel et al., Psychological interventions to build mental wellbeing can have a vital role in reducing the pressure and burden of illness (Slade, To date, three RCTs have reported the effectivenes... | PMC10726803 |
METHODS | PMC10726803 | |||
Design | SECONDARY | This was an RCT with a pretest–posttest design and two arms, in which a 4‐week G‐ACT intervention was compared to usual care. The primary and secondary outcomes were collected using interviews before the intervention and immediately after the intervention in hospital, and then again 3 months later (follow‐up assessment... | PMC10726803 | |
Setting | acute stroke | ACUTE STROKE | This study was conducted at the PLA Rocket Force Characteristic Medical Center, which is a large hospital with acute stroke in‐patient treatment. | PMC10726803 |
Patients | mental illness, HAMD, drug abuse or dependence, cognitive impairment, stroke, neurological disorder, dementia, bipolar disorder, Acute stroke, psychiatric, psychotic symptoms, Depression | ACUTE STROKE, NEUROLOGICAL DISORDER, STROKE | Acute stroke patients who had been hospitalized at the PLA Rocket Force Characteristic Medical Center were recruited from August 2020 to February 2021. The inclusion criteria were as follows: (1) primary diagnosis of stroke with a confirmation of magnetic resonance imaging or computed tomography, and with the last onse... | PMC10726803 |
Randomization | STRUCK | One hundred and forty patients gave written informed consent for this study, based on the Declaration of Helsinki, and were randomly assigned to one of two groups: G‐ACT or control group. Two independent researchers who did not participate in assessing patients took charge of the randomization using the lottery method.... | PMC10726803 | |
Intervention | tearing, stroke | STROKE | The patients included to the control group received usual care support in hospital, and the patients included to the intervention group received G‐ACT and usual care support. Based on the Hayes and Wilson (Session‐by‐session outline of acceptance and commitment therapy course.Getting to know stroke, from a broader pers... | PMC10726803 |
Primary outcome | PMC10726803 | |||
Depression | HAMD | The HAMD or HDRS (Hamilton, | PMC10726803 | |
Secondary outcomes | PMC10726803 | |||
Health‐related quality of life (HRQoL) | Health‐related quality of life (HRQoL) was assessed using the Short Form Survey Version 2 (SF‐12v2) (Ware et al., | PMC10726803 | ||
Psychological flexibility | The Acceptance and Action Questionnaire II (AAQ‐II) (Bond et al., | PMC10726803 | ||
Cognitive fusion | The Cognitive Fusion Questionnaire (CFQ) (Gillanders et al., | PMC10726803 | ||
Sleep quality | The Pittsburgh Sleep Quality Index (PSQI) (Buysse et al., | PMC10726803 | ||
Confidence | stroke | STROKE | The confidence was assessed using the confidence after stroke measure (CaSM) (Horne et al., The posttest and follow‐up assessment were administered by a trained research assistant who was unaware of each patient's treatment allocation, and the patients were asked not to reveal to her the types of treatment that they re... | PMC10726803 |
Statistical analyses | SPSS software version 20 was used for data analysis. Pearson | PMC10726803 | ||
RESULTS | stroke | STROKE, CEREBRAL INFARCTION | One patient in the control group declined to complete the second assessment before discharge. Of the patients in the intervention group, 9 (12.9%) patients participated in 5 sessions, 21 (30%) patients participated in 6 sessions, and 40 (57.1%) patients participated in all sessions. Finally, 139 patients (91 males, 48 ... | PMC10726803 |
Primary outcome | depression, Depression | There was no significant statistical difference regarding the score of HAMD at pre‐intervention between the two groups (Estimated means of primary outcome across time by treatment condition.
Abbreviation: HAMD, the Hamilton Depression Rating Scale.Repeated measurement analysis of variance of depression across time by t... | PMC10726803 | |
Secondary outcomes | stroke | STROKE, SECONDARY | There were no significant statistical differences regarding the score of MCS, PSQI, AAQ, CFQ, and CaSM at pre‐intervention between the two groups (Estimated means of secondary outcome across time by treatment condition.
Abbreviations: AAQ, the Acceptance and Action Questionnaire; CaSM, the confidence after stroke measu... | PMC10726803 |
DISCUSSION | stroke, psychiatric, psychotic symptoms, depression, acute stroke | STROKE, ACUTE STROKE | This study found that the G‐ACT intervention significantly reduced depression in acute stroke patients when compared with the control group at post‐intervention and this difference persisted at 3 months, which echoes the findings of RCTs using G‐ACT with acute stroke patients (Niu et al., Most of the included patients ... | PMC10726803 |
Strengths and limitations | depression, psychiatric, acute stroke | ACUTE STROKE | To our knowledge, this is the first large‐scale trial which focused on testing the effectiveness of G‐ACT in treating depression for acute stroke patients. The results showed that G‐ACT could reduce depression, and the effect was still significant over time (partial This study has several limitations. The study was con... | PMC10726803 |
CONCLUSION | depressive symptoms | ACUTE STROKE | This study found that G‐ACT could significantly reduce depressive symptoms in patients with acute stroke, and the interventional efficacy was maintained at 3‐month follow‐up (partial η | PMC10726803 |
AUTHOR CONTRIBUTIONS | PMC10726803 | |||
CONFLICT OF INTEREST STATEMENT | The authors declare that they have no conflicts of interest. | PMC10726803 | ||
FUNDING INFORMATION | Beijing Municipal Science & Technology Commission (Grant Number: Z181100001718041) | PMC10726803 | ||
PATIENT CONSENT STATEMENT | All included patients gave written informed consent for this study, based on the Declaration of Helsinki. | PMC10726803 | ||
CLINICAL TRIAL REGISTRATION | PMC10726803 | |||
PEER REVIEW | The peer review history for this article is available at | PMC10726803 | ||
ACKNOWLEDGMENTS | We thank all researchers and patients for their participation in the study. This work was funded by Beijing Municipal Science & Technology Commission (Grant Number: Z181100001718041). | PMC10726803 | ||
DATA AVAILABILITY STATEMENT | The datasets used and/or analyzed during the current study are available from the first author on reasonable request. The funding agency demands that the data cannot be shared publicly until 3 years after it has been collected. | PMC10726803 | ||
REFERENCES | PMC10726803 | |||
1. Introduction | end-stage knee osteoarthritis, OA, Pain, ±, muscle soreness, pain, knee arthroplasty, balance dysfunction, TKA, knee flexion and extension ROM, knee pain | We investigate the effect of a 1-week comprehensive foam rolling (FR) intervention program on knee pain, range of motion (ROM), and muscle function in patients with TKA.Thirty patients with TKA were randomly allocated to FR (n = 15) or control (n = 15) groups. The control group received only regular physical therapy. P... | PMC9961826 | |
2. Materials and Methods | PMC9961826 | |||
2.1. Experimental Design | knee flexion and extension ROM, pain | CONTRACTION | We used a randomized, repeated-measures experimental design to compare the effects of a 1-week FR intervention on patients with TKA. The FR intervention was performed from the second to third postoperative weeks (1 week). The FR intervention program consisted of 60s × 3 repetitions × 2 times/day × 6 days (for a total o... | PMC9961826 |
2.2. Participants | The study population consisted of 30 patients admitted to our hospital who underwent TKA for knee OA (The mean age of the FR group was 75.9 ± 6.0 years (range: 61–83 years), and the mean body mass index (BMI) was 26.8 ± 2.9 kg/m | PMC9961826 | ||
2.3. Regular Physical Therapy Intervention | knee flexion, TKA, pain | Regular physical therapy was started on the day after surgery. All participants performed wheelchair practice, ROM exercises, strength training, and walking training according to their pain and general conditions. Our TKA protocol is to perform walking exercises with a walker one week after surgery, with a goal of 90° ... | PMC9961826 | |
2.4. FR Exercise | TKA | Our TKA protocol performs wound extraction in the second postoperative week. After the physical therapist confirmed there were no problems with the wound, a roller massager (TheraBand, Akron, OH, USA) was used in the second postoperative week after the extraction. FR was performed for 60 s each in the order of anterior... | PMC9961826 | |
2.5. Knee Flexion and Extension ROM Measurement | knee flexion and extension ROM | BLIND | The physical therapist measured knee flexion and extension ROM using a goniometer [The participant was laid in a supine position, and passive knee flexion and extension ROM that could be tolerated was measured. Measurements were performed on the bed. In this study, we were not able to blind the investigators to the int... | PMC9961826 |
2.6. Pain Measurement | knee pain, pain | Before FR intervention was performed in the second postoperative week, the degree of pain was measured using the VAS during knee joint ROM measurement. The VAS allows patients to estimate knee pain by marking an X on a 100-mm line (0 mm for no pain, 100 mm for worst possible pain). The pain was defined as the pain at t... | PMC9961826 | |
2.7. Walking Measurements | In the FR group, measurements were obtained before FR at two and three weeks postoperatively. Walking speed was measured using a stopwatch at a comfortable walking speed of 10 m. A 3-m spare path was set up at the start and end of each measurement line, and measurements were taken twice. For all variables, the average ... | PMC9961826 | ||
2.8. Balance Measurements | Balance was measured using the TUG [ | PMC9961826 | ||
2.9. Muscle Strength Measurement | We measured isometric knee extensor muscle strength using a handheld dynamometer (Micro FET 2; Nihon Medix, Chiba, Japan). Muscle strength measurements via HHD were performed by the same well-trained physical therapist with more than ten years of experience. The method was based on a previous study [ | PMC9961826 |
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