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Title: Canine Tooth Microbiome Gingival Index: a new microbiome-derived measure of gingival health validated by nutritional intervention. Background: Periodontitis affects over 80% of dogs over 3 years of age, progressing irreversibly from gingivitis due to an imbalance in the subgingival microbial community that trigg... | The two top-performing models-random forest and logistic regression-yielded 22 unique features. These 22 features included the sum of early and late colonizers, the phyla actinobacteria and proteobacteria, and other bacterial species. The CTMGI was derived from the 22 features, categorized as "positive" or "negative" b... | FMDV infection in oral mucosal epithelial swabs (ct = 28.9), saliva (ct = 30.62), and blood plasma (ct = 37.17) compared to controls used from the Farma Veterinary Center (ct = 29.10) using RT PCR (3D gene). These results indicate that the sensitivity value of oral mucosal epithelial swab specimens is the same as posit... | The study included a random sample of 22,333 dogs. The 1-year period prevalence for diagnosis with periodontal disease was 12.52% (95% CI: 12.09 to 12.97). Eighteen breeds showed increased odds compared with crossbred dogs. Breeds with the highest odds included Toy Poodle (odds ratio 3.97, 95% confidence intervals 2.21... | IMHA/ITP is associated with remodeling of fecal microbiota, marked by decreased relative abundance of the spirochete Treponema spp., increased relative abundance of the pathobionts Clostridium septicum and Escherichia coli, and increased overall microbial diversity. Logistic regression analysis demonstrated that Trepon... | The overall response rate was 14.7%, with a best overall response rate of 16.7%. Treatment-related adverse events occurred in 40.0% of the dogs, which were primarily grade 1-3. Increased baseline white blood cell, neutrophil count, and C reactive protein levels were significantly associated with poor response, shorter ... | The analysis included a random sample of 1,835 confirmed incident acute diarrhoea cases in 2019 from an overall study population of 2,250,417 dogs. After accounting for subsampling, the estimated one-year incidence risk for acute diarrhoea in dogs overall was 8.18% (95% CI: 7.83-8.55). Of the first acute diarrhoea even... | 42328069 | Frontiers in veterinary science | [
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Title: Evaluating the synergistic effects of cisplatin and tamoxifen in canine osteosarcoma cells. Background: Canine osteosarcoma is an aggressive primary bone tumor with a high metastatic rate and poor long-term prognosis. Therapeutic resistance remains a major cause of treatment failure. In human osteosarcoma, sex h... | Synergy analysis at 24 hours demonstrated strong synergistic activity between tamoxifen and cisplatin, with a ZIP score of 16.82. Combination treatment reduced metabolic activity and activated apoptotic markers at lower drug concentrations compared with either treatment alone. Although estrogen receptor expression was ... | Eleven dogs were enrolled in this prospective study. High grade adverse effects were common, especially if bone was included in the treatment field. Four out of six dogs, who had bone in their treatment field and lived at least 5 months after RT, developed osteoradionecrosis at 3-12 months post treatment. The treatment... | The dose determination study showed the systemic administration of ePB-MSCs in a canine OA model resulted in an analgesic, anti-inflammatory, and joint tissue protective effect associated with improved clinical signs and improved cartilage structure, as well as a good safety profile. Furthermore, a clear dose effect wa... | A single TT treatment resulted in 75% complete response (CR) (95% confidence interval [CI] = 61-86) by 28 days, with no recurrence in 93% (95% CI = 82-97) of dogs by 84 days. Eight TT-treated dogs that did not achieve CR in phase 1 achieved CR after retreatment, increasing the overall CR to 88% (95% CI = 77-93). Contro... | SOD treatment resulted in anti-proliferative effects and mediated cell cycle arrest in the canine mammary gland tumour cell lines (CIPp and CIPm). It also downregulated the expression of N-cadherin and Vimentin. The results confirmed that SOD inhibits tumour cell proliferation and migration, thus supporting the potenti... | Cannabidiol reduced cell viability and induced apoptosis in canine urothelial cells as determined by crystal violet viability assay and annexin V/propidium iodide flow cytometry. Furthermore, combinations of cannabidiol with mitoxantrone and vinblastine chemotherapy yielded significantly reduced cell viability and incr... | 42328057 | Frontiers in veterinary science | [
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Title: First molecular detection of <i>Theileria haneyi</i> infection in horses in Southern Spain. Background: Equine piroplasmosis (EP) is a tick-borne disease of equids caused by the hemoparasites <i>Theileria equi, Babesia caballi</i>, and <i>Theileria haneyi</i>. <i>T. haneyi</i>, a close relative of <i>T. equi</i>... | Three horses out of 222 (3/222; 1.35%) were positive for <i>T. haneyi</i>. These three positive horses were located in Southern Spain in the provinces of Huelva, Cadiz, and Malaga. Additionally, 76 (76/222; 34.2%) were positive for <i>T. equi</i>. All three <i>T. haneyi</i>-positive horses were also found PCR-positive ... | Despite the circulation of zoonotic tick-borne pathogens among livestock and tick vectors, human infections have been overlooked and are potentially limited to infer the actual communicable disease burden. Therefore, facility-based surveillance of TBDs, combined with capacity building for laboratory diagnostics in heal... | Clinical examination revealed non-painful, nonpruritic growths ranging in diameter from 2 to 8 mm. Histopathological analysis of skin biopsies showed thickening and hyperplasia of all epidermal layers, accompanied by acanthosis, hyperkeratosis, and the presence of koilocyte within the stratum spinosum and granulosum. M... | In our study, Taylorella equigenitalis was found infrequently (53 out of 25,512 samples), representing 11 out of 2308 stallions. If T. equigenitalis was detected, the stallions were treated with antibiotics and re-tested later in the same year. Klebsiella pneumoniae and beta haemolytic streptococci were the most common... | All horses exhibited acute signs of neurologic disease including ataxia and proprioceptive deficits. Horses tested positive for TBEV using virus neutralization test and samples were further tested for TBEV-specific IgM. The presence of TBEV-specific IgM antibodies was confirmed in 5 horses (cases 1-5, Laboratory Unit [... | Collectively, the SNAP<sup>®</sup> 4Dx<sup>®</sup> Plus Test provided 64% seropositive results, comprising Ehrlichia species (59%), Anaplasma species (45%), Dirofilaria immitis (2%), and Borrelia burgdorferi (< 1%). Altogether, prevalence as determined by probe-based qPCR assays was 54%, comprising Ehrlichia canis (27%... | 42328053 | Frontiers in veterinary science | [
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Title: Assessment of Ocular Surface Pathogen Susceptibility to Ultraviolet-C (UVC) Light Treatment With a Novel Prototype Device-An In Vitro Study. Background: Assess in vitro efficacy of a device emitting 265 nm UVC light against bacteria isolated from veterinary infectious keratitis. | UVC inhibition was complete in 11/30 isolates at ≤ 5 s exposure. Partial efficacy was seen in 18/19 remaining isolates at 5 s; ≥ 33% zones demonstrated absence of bacterial growth. Efficacy against MDR-MRSP and MDR-E. coli was comparable to susceptible counterparts. All P. aeruginosa were completely inhibited at ≤ 5 s;... | The mean (SD) tear film osmolality was 283.51 (9.33) mmol/kg, and the mean (SD) sodium, potassium, magnesium and calcium concentrations were 134.75 (10), 16.3 (5.77), 3.48 (1.97) and 1.06 (0.42) mmol/L, respectively. The sodium concentration in the tear film was similar to that in serum, whereas the potassium concentra... | We have developed a feasible method for photodynamic antibacterial therapy, possessing excellent biocompatibility and high antibacterial efficiency with good fluorescence imaging property. | IMMK subtype was classified as 10/94 (10.6%) epithelial, 50/94 (53.2%) anterior stromal, 14/94 (14.9%) mid-stromal, 4/94 (4.25%) endothelial and 16/94 (17.0%) unrecorded. After excluding three horses with incidental corneal ulceration, blepharospasm was documented in 34/91 (37.4%), corneal ulceration in 26/91 (28.6%), ... | We developed a rapid assay (RPAS) combining RPA with SYBR Green I for the detection of BVDV. The BVDV RPAS assay was performed at 37 °C in 25 min. The minimum detection limit of the RPAS assay is 1 × 10<sup>9</sup> copies/µL in sunlight and 1 × 10<sup>5</sup> copies/µL in ultraviolet light, and there is no cross-reacti... | The statements covering the following topics were analyzed in this paper: (i) Understanding photobiomodulation via FLE; (ii) Indications and Protocols for FLE; and (iii) FLE pet owner information. Consensus was reached on 33 out of 33 statements (100%) addressing the use of photobiomodulation via FLE; the practical mod... | 42321970 | Veterinary ophthalmology | [
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Title: Granulosa Cell Tumour in a Spayed Cat With Ovarian Remnant Syndrome and Hyperestrogenaemia Without Estrus Signs. Background: Granulosa cell tumour (GCT) is the most common primary ovarian neoplasm in cats and may arise from residual ovarian tissue following incomplete spay procedures. To describe the surgical ma... | Histopathology confirmed GCT in the abdominal mass with hepatic metastasis. A preoperative serum sample collected at initial presentation and assayed after receipt of the histopathology report showed markedly increased estradiol. Although clinical signs improved after surgery, the cat re-presented 4 weeks later with ab... | Fourteen dogs with 16 tumors were included, of which nine tumors were treated for gross disease whilst seven tumors were treated post-surgery for microscopic residual disease. Four treatment sites treated with 35 Gy had ulceration post irradiation, which was graded as severe adverse effect. Only mild adverse effects we... | A total of 64 cases of canine TVT were diagnosed. 52 dogs were cross-breed (81.2%) while 4 Siberian Huskies (6.2%) and 3 German shepherds (4.7%) were the most affected pure-breed dogs. The median age of dogs at diagnosis was 3 years (range, 1-10years) and male gender was more common (male:female ratio; 1.3:1). Tumor wa... | The largest group were canine tumours, of which there were 9,745 (85.95%), followed by feline tumours, totalling 1,397 (12.32%), tumours from exotic animals (186; 1.64%), from horses (7; 0.06%), and from cows (2; 0.02%). A significant number of cases of animals suffering from more than one tumour were also found, which... | This case illustrates a granulomatous interstitial polymyositis and intramuscular neuritis that improved clinically and resolved histologically with glucocorticoid treatment. Idiopathic granulomatous myositis and neuritis should be considered as a differential diagnosis in dogs with clinical signs of neuromuscular diso... | Twenty-nine tumors were classified as luminal and 27 tumors as basal subtype. Basal tumors were strongly associated with immune infiltration (OR 52.22, 95%CI 4.68-582.38, <i>P</i> = 0.001) and cancer progression signatures in RNA-seq analyses, more advanced clinical stage, and earlier onset of distant metastases in exp... | 42319189 | Veterinary medicine and science | [
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] |
Title: 'Helpful', 'Objective', and 'Useful': User Perceptions of the Animal Welfare Assessment Grid (AWAG) for Dogs as a Decision-Making Tool. Background: Ethical decision-making in veterinary practice and in animal welfare sectors can be particularly challenging. Decision-making is reported to be largely subjective wi... | Over 96% of respondents acknowledge the utility of the AWAG in aiding in decision-making and it is reported to facilitate discussions among colleagues and dog caregivers about welfare. While the overall sentiment towards the AWAG was predominantly positive, a minority of users expressed difficulties in using the tool, ... | A total of 208 registered veterinarians participated in this study. The study involved a majority of male participants, constituting 85.1%, while 54.8% of the participants held a Masters degree. Around 52% of the veterinarians were poultry practitioners. All respondents were familiar with antimicrobials. The participan... | Based on interview findings, ten items were reworded, four removed, and two added; resulting in 26 items that all owners understood and considered relevant. The recall period and response options were well understood and appropriate to almost all owners. To evaluate its psychometric properties, the CaOA-QoL-TS (draft 2... | Analysis revealed significant anxiety and fear associated with medication administration, with 12% of posts mentioning anxiety and additional fear-related terms appearing in 1-3% of posts. Only 7.6% of posts discussed soft/chewable medications, which showed positive sentiment and preference. Geographic analysis showed ... | A total of 15,725 records were submitted by the 14 participating pharmacies and 91 records were entered by the 15 participating farmers. Overall, the participants were positive about the system and were able to use it. The information available was appreciated by the farmers. The pharmacy representatives appreciated ge... | In cases n. 2, 3, 4, 5, 7 owners of dogs affected with CAD partial or full reimbursement from the seller obtained. In cases n. 9, 10, 11, 12, and 13, dog owners could not take any legal action because the diagnosis of CAD was made beyond the time limits required by law. In cases n. 1, 6, and 8, the owners decided not t... | 42319182 | Veterinary medicine and science | [
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Title: A non-trauma-focused equine-assisted intervention was associated with reductions in all four PTSD symptom clusters in treatment-resistant military veterans. Background: Veterans are at greater risk of developing post-traumatic stress disorder (PTSD) and show a poorer response to first-line treatments than civili... | A linear mixed model showed that scores for all four PTSD symptom clusters significantly improved over the course of the program. Cluster B (intrusion) and cluster C (avoidance) decreased even further after termination of the program at week 12, demonstrating additional long-term effects. Cluster D (negative changes in... | The multinomial logistic regression analysis found no statistically significant association between intervention (cHAT) and treatment outcome (completion, dropout, transferred) among the 37 participants who were ultimately recruited to the study. Some unforeseen challenges were encountered in the study: a high number o... | Twenty-four owners of 22 Addisonian dogs took part in four events. Owners felt most "traumatised" when experiencing their dog's acute adrenal crisis. The initial adjustment phase and distinguishing the non-specific symptoms of hypoadrenocorticism from those of other diseases were also challenging. Overall, owners were ... | Of the 27 acute and chronic wounds included in the analysis, 81.48% showed complete healing after the administration of CAMP as an adjunct therapy to standard care. Most wounds achieved complete healing in < 5 weeks. Compared with the pre-CAMP period, the rate of wound healing significantly increased every week in the ... | Fifty-five of 60 students (91.7%) that completed the questions on mistreatment indicated that they experienced and/or witnessed a mistreatment during veterinary education. 92% of students that experienced a mistreatment said that it interfered with the learning environment but only 29% of students reported the mistreat... | Interest in interventions such as neurofeedback, transcranial direct current stimulation, music therapy, equine-assisted therapy, virtual reality, and gamification has grown substantially. However, most of these approaches lack methodological standardization and robust evidence to justify their use as primary treatment... | 42317715 | Frontiers in psychology | [
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Title: Clinical and radiographic evaluation of manus and pes lesions, including the carpus and tarsus, and associated risk factors in dromedary camels <i>(Camelus dromedarius)</i>. Background: Injuries of the Manus and Pes, including the carpus and tarsus are a primary cause of lameness and subsequent economic loss in ... | Clinical and radiographic assessments identified 325 distinct lesions. Hard-tissue lesions (62.5%)-predominantly fractures, joint dislocations, and bony exostoses, were significantly more prevalent than soft-tissue lesions (37.5%), such as fibromas, flexural deformities, wounds, and penetrating solar nails. These condi... | The most frequently recorded lesions were digital dermatitis (32%), white line disease (21%), sole ulcer (19%) and sole haemorrhage (13%). White line disease had the highest percentage of lesions requiring veterinary attention and most frequently re-presented. Most lesions were in hind feet and there was a small but si... | This case report describes the clinical signs, diagnostic procedures and pathological findings in an adult female alpaca suffering from cranial nerve abnormalities caused by a massive otogenic brain abscess. Camelids suffering from otitis may not present with clinical signs until the pathology is severe. The importance... | Odds of survival were 3.9 times higher in camelids with a total nucleated cell count (TNCC) <3 cells/μL (P = .04). No significant association was found between survival and total protein concentration (TPC; P = .15) or percentage of eosinophils (P = 1.0). No significant correlation was found between species and increas... | Horses underwent one (n = 107), two (n = 19), or three (n = 2) surgeries. Survival to hospital discharge was 84.4%. Univariable survival analysis revealed that administration of systemic antimicrobials prior to referral was associated with reduced mortality (hazard ratio, [HR] 0.41, 95% CI 0.18-0.91, P = 0.03). Increas... | The clinical examination showed grade III-IV lateral PL. Radiologically, there were unilateral or bilateral, ventrocaudal, and dorsal PLs. Two cases were referred to surgical correction. One case almost restored the normal movement of stifle joint together with a good general status 1 year postsurgery. However, the sur... | 42317456 | Frontiers in veterinary science | [
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Title: Clinical factors, service type, and clinical outcomes associated with canine parvovirus in dogs presented at the KNUST Veterinary Teaching Hospital in Kumasi, Ghana. Background: Canine parvovirus (CPV) continues to be a predominant cause of morbidity and mortality among dogs worldwide. In Ghana, data on clinical... | A total of 129 CPV-positive dogs were diagnosed, with an overall mortality rate of 26.4% (34/129), compared to 8.5% (7/82) among CPV-negative dogs. Haemorrhagic diarrhoea (OR = 6.84), vomiting (OR = 2.75), lower body weight (OR = 0.94 per kg increase), and complete loss of appetite (OR = 4.29) were significant independ... | Fifty and 64 dogs were in ACVIM stage B1 and B2, respectively. The presence of LRTD was prevalent in 74.6% (85/114) of small-breed dogs with preclinical MMVD. When a previously reported criterion for CPE diagnosis (≥2 sites with >3 B-lines/site) was applied, false-positive results were observed in 15.8% (18/114) of dog... | The study included 23 CDV-infected dogs with neurological signs, 10 diseased but CDV-negative (non-infected) dogs, and 12 healthy controls. CSF samples were analyzed using Reverse Transcription Polymerase Chain Reaction (RT-PCR) for CDV sequences and the sandwich enzyme-linked immunosorbent assay (ELISA) method for qua... | From the study, it was found that the endoparasitic infestation was highly frequent in both dog and cat (55% in dogs and 59% in cats). The endoparasitic infestation was highly prevalent in cats (91.53%) significantly (<i>p</i> = 0.003), which were ≤1 year of age. On the other hand, the ectoparasitic infestation was fou... | Venous blood samples were collected from dogs without clinical signs (n = 30) and with clinical signs (n = 35) suggestive of Leishmania infantum infection. Among 65 samples examined, Leishmania DNA was detected by nested-PCR in 89.23% (58/65). Furthermore, 86.15% (56/65) nested-PCR positive samples were also DAT po... | Common examination findings in dogs with a presumed antemortem diagnosis included fever (21%) and heart murmur (19%). Median cardiac troponin I was 12.2 ng/mL (range: 0.2-808.0 ng/mL), and troponin exceeded 1.0 ng/mL in 26 of 29 (90%) dogs. Ventricular ectopy was the most common arrhythmia (54%), whereas decreased left... | 42316295 | Companion animal health and genetics | [
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] |
Title: Transcranial photobiomodulation therapy with 808 nm and 1064 nm can affect different behavior parameters in dogs. Background: To evaluate if transcranial photobiomodulation could improve behaviors in working dogs. | The animals in the sample had a mean age of 4.4 ± 2.0 years, with 24 males and 12 females. Three breeds were represented: Belgian Malinois Shepherd Dogs (n = 23), Dutch Shepherd Dog (n = 8), and German Shepherd Dogs (n = 5). Changes in the CFQ, L-CARS, and components were mainly driven by improvements in TG1064, with a... | In total, 138 dogs were presumptively diagnosed with MUO. The most common location for lesions identified on MRI were the white matter tracts of the corona radiata and corpus callosum, followed by the frontal, sensorimotor and temporal cortices. Lower T2 lesion load (<i>p</i> = 0.006, OR = 0.942, CI = 0.902-0.983) was ... | Breeds represented most often included the Golden Retriever (n = 12), Bernese Mountain Dog (10), Wirehaired Pointing Griffon (9), Boxer (9), and Beagle (6). No breed differences were identified with respect to clinical severity, diagnostic findings, or outcome. Twenty-nine dogs (48%) had ≥1 disease relapse. There was a... | While STT-1 showed no significant difference among dog groups, brachycephalic dogs had significantly lower values in TBUT, NIBUT, and LLT, and a higher TMH, compared to mesocephalic and dolichocephalic dogs. Additionally, brachycephalic dogs exhibited a significantly higher MGLRL than dolichocephalic dogs. Correlations... | The survey received a 35% response rate, for a total of 180 participant responses. Fewer than 50% of veterinary neurologists are currently performing EEG and it is performed infrequently. The most common indication was to determine a discrete event diagnosis. Other reasons included monitoring treatment, determining bra... | The DCE-MRI analysis of the piriform lobe identified higher BBBP score in the IE group when compared with controls (34.5% vs 26.5%; P = .02). Activity and expression of MMP9 were increased in the serum, CSF, and piriform lobe of IE dogs as compared with controls. Gene expression of Kir4.1 and claudin-5 in the piriform ... | 42315691 | Lasers in medical science | [
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] |
Title: Type 1 Collagen/Poly-L-Lactic Acid Biocomposite Augmentation of a Nontraumatic Symptomatic Complete Rotator Cuff Tear. Background: Treatment modalities for rotator cuff tears are continuously evolving. Augmentation of rotator cuff repair with biocomposite implants with bioinductive properties such as collagen sc... | This biocomposite implant provides an encouraging option for use in patients with poor tissue quality or tear patterns that are concerning for possible postoperative retear. | Compared to controls, genipin treatment increased ultimate force by 19% in degenerated tendons (median control 530 N vs. 633 N; p = 0.0078). No significant differences in mechanical properties were observed in healthy tendons, while degenerated tendons showed a significant difference in ultimate stress (+23%, p = 0.049... | The shift of COL1/2 ratio toward COL2A1 was more pronounced in HA, and cells displayed a more spherical morphology compared with CS. BMP-2 and IL-10 significantly increased COL2A1, SOX9, and ACAN expression, which was paralleled by enhanced staining of glycosaminoglycans (GAGs) and type 2 collagen in histological secti... | Observations revealed a statistically significant loss of sulphated glycosaminoglycan (sGAG) using both Collagenase Treatment (CT) and Collagenase and Aggrecanase Treatment (CAT), while chondrocytes viability was maintained. Both treatments resulted in a significantly elevated release of inflammation markers during the... | The in vivo histology of the graft site after 3 years has shown that heterologous bone is a safe and valid choice as a scaffold for bone regeneration. Augmentation with NHA bone paste achieved good osteoinduction without an inflammatory reaction and good integration of the bone substitute insert. | Micro-CT indicated adequate volume stability in all block materials. Histologically, the addition of rhBMP-2 increased the amount of newly formed bone (NB) in all the blocks. At 2 weeks, minimal differences were noted among the NB of groups with or without rhBMP-2. At 12 weeks, the PBC+M group with rhBMP-2 presented th... | 42311585 | Ochsner journal | [
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Title: A multicenter retrospective analysis of canine idiopathic epilepsy in China. Background: Canine idiopathic epilepsy (IE) is one of the most common neurological diseases in veterinary medicine, with no comprehensive study in China. This study collected IE cases from five large referral pet hospitals and conducted... | A total of 211 cases with IE were included in the study. Male dogs (<i>p</i> < 0.05), small dogs weighing <10 kg (<i>p</i> < 0.05), poodles (<i>p</i> < 0.05) had a significantly higher risk to be diagnosed with IE. The age of first seizure episode was mainly between 1 and 5 years, with an average of 4 years. Most patie... | Dogs with rostrotentorial brain tumors had EPS after 16/125 (12.8%) neurosurgical procedures (95% confidence interval [CI], 7%-19%). Presence of previous structural epilepsy was not associated with EPS risk (P = 1). Perioperative ACD use also was not associated with EPS (P = .06). Dogs with EPS had longer hospitalizati... | Ambulatory EEG was diagnostic in 60.2% of all dogs including 49% of the sedation/GA dogs and 68% of dogs that received neither (odds ratio [OR], 2.25; 95% confidence interval [CI], 1.02-5.00; P = .05). The AEEG was diagnostic in 51% of dogs receiving at least 1 ASD and 66% of untreated dogs (OR, 1.95; 95% CI, 0.9-4.3; ... | Lissencephaly should be considered an important differential diagnosis in Shih Tzu dogs presenting with early-onset signs of forebrain abnormalities, including cluster seizures and behavioral alterations. Magnetic resonance imaging was appropriate for ante-mortem diagnosis of lissencephaly and associated cerebral anoma... | Breeds represented most often included the Golden Retriever (n = 12), Bernese Mountain Dog (10), Wirehaired Pointing Griffon (9), Boxer (9), and Beagle (6). No breed differences were identified with respect to clinical severity, diagnostic findings, or outcome. Twenty-nine dogs (48%) had ≥1 disease relapse. There was a... | Two hundred seven dogs could be assigned to IVETF response categories 1-3. The proportion of responders (59%, n = 123), including categories 1 (29%) and 2 (30%), was higher than non-responders (category 3, 41%, n = 84; P < .01). Based on the responders, an RI of 10-55 μg/mL is proposed. This study demonstrated that ZNS... | 42311395 | Frontiers in veterinary science | [
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Title: Thickness distribution and site-specific variability of thermoformed multilayer clear aligners: an <i>in vitro</i> study. Background: Thermoforming is a critical step in the fabrication of clear aligners and is associated with non-uniform deformation of thermoplastic materials, resulting in non-uniform thickness... | Significant differences in thickness were observed among tooth regions (<i>p</i> < 0.001), with the lowest values in anterior teeth (404.0 ± 5.9 µm) and the highest in molars (481.6 ± 6.0 µm). Thickness reduction ranged from approximately 36% to 47% relative to the original material. Site-specific analysis demonstrated... | Eleven publications were included in this review (4 CCTs and 7 RCTs). No study presented low risk of bias. Different types of tooth movement were evaluated: lower anterior alignment, en-masse retraction, overall orthodontic treatment and canine distalization. A total of 240 participants were analyzed in the included st... | : All CAT-based total distalization groups showed an overall trend of clockwise or counterclockwise rotation of the occlusal plane as the force direction varied. Mesiodistal tipping of individual teeth was more prominent than that of bodily movements. The initial displacement pattern of the mandibular teeth was more pr... | Dental anomalies have multiple effect on the occlusion as well as on the esthetic. Early diagnosis and intervention and collaboration between the different subspecialty are needed. Pedodontics, orthodontic, restorative, and prosthodontic consultation was taken for the best future proposed treatment that ranges between ... | VLPPP showed the highest tooth displacement pattern of 0.017 mm with incremental rotational force application but also exhibited highest stress concentration at PDL and alveolar bone level of 516.10 Mpa. VL showed the least tooth movement of 0.012 mm and lowest stress levels of 374.33 Mpa. VLPPP generated the highest f... | The integration of multiloop orthodontic mechanics and periodontal crown lengthening represents a predictable and comprehensive interdisciplinary strategy for managing deep bite with a gummy smile, resulting in significant improvements in occlusion, tooth proportions, and facial esthetics. | 42306039 | Frontiers in dental medicine | [
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Title: Next frontier in endovascular aortic therapy: An anatomic analysis of feasibility of endovascular treatment of ascending thoracic aortic aneurysms. Background: Ascending thoracic aortic aneurysms (ATAAs) are the next frontier for endovascular aortic repair. This study evaluates anatomic characteristics of ATAAs ... | In total, 150 consecutive patients with ATAA ≥5 cm and high-quality computed tomography scans were included. A diameter between 27 and 48 mm existed in 46% (69/150) of patients at the proximal landing zone and 94% (141/150) at the distal landing zone. Arch branching was normal in 68% (102/150), bovine in 21% (38/150), ... | Despite the relevant perioperative morbidity and mortality associated with EVAR infection, endograft explantation and in situ reconstruction with preferably bovine pericardial grafts may offer definitive treatment of infection, with promising mid- and long-term results. | From July 2017 to July 2018, 60 patients underwent implantation of the Dafodil pericardial bioprosthesis. Post-operatively, NYHA functional class significantly improved in all the patients (Aortic: 90% NYHA class-I and 10% NYHA class-II; Mitral: 96.55% NYHA class-I and 3.45% NYHA class-II; P < 0.001). There was no deat... | A 68-year-old male was admitted to the hospital due to severe abdominal pain. The patient was afebrile, hemodynamically stable with elevated C-reactive protein levels. A physical examination revealed a palpable, pulsatile, tender mass located in the periumbilical region. Ultrasonography and multi-slice computer tomogra... | In the present case, prompt treatment decisions and smooth cooperation among the institutional heart team led to the successful repair of aortic root rupture during TAVI and good clinical outcomes. | This case illustrates a successful approach to orthotopic heart transplantation in a child with failing Fontan circulation supported by a VAD. Reconstruction of the pulmonary artery using a large pericardial patch and restoration of bicaval continuity were key to overcoming complex anatomical challenges. | 42305689 | JTCVS structural and endovascular | [
0.5221665501594543,
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0.3539655804634094,
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] |
Title: Congenital central nervous system malformations in piedmontese calves-part 1. structural brain disorders. Background: Congenital central nervous system (CNS) malformations in cattle are likely underreported, and their true incidence, clinical spectrum, and etiological factors remain poorly characterized. This st... | In total, 70 calves underwent necropsy for suspected CNS anomalies. Structural brain defects were confirmed in 11 calves. Hydrocephalus (6/11) was the most frequent finding and was commonly associated with cerebellar malformations. Isolated Dandy-Walker-like malformations were found in 2/11 and cerebral aplasia in 3/11... | The prosencephalon was the most commonly affected location (81 cases, 19.6%), followed by multifocal involvement (62 cases, 15%) and the T3-L3 spinal cord (56 cases, 13.5%). Infectious diseases, especially canine distemper diseases, were the most common cause, accounting for 136 cases (33.2%). Unknown causes ranked sec... | Fifty-two horses had EPM; 23 were confirmed on necropsy, and 29 were presumptive clinical diagnoses. The other 47 horses all had necropsy-confirmed diagnoses. Four of the 47 horses had normal neurologic findings on necropsy and the remaining 43 horses had neurologic diseases including equine degenerative myeloencephalo... | This is the first case in veterinary literature in which a grass awn has been surgically extracted from the brain of a dog with long-term outcome described. Observed changes in the extracranial musculature were fundamental to establish the pre-surgical diagnosis of a migratory foreign body. | One hundred eighty-eight patients were included in the study with a median age of 6.9 years (range 3 months to 14.6 years). Neurological abnormalities included head tilt (n = 185), ataxia (n = 123), facial paralysis (n = 103), nystagmus (n = 97), positional strabismus (n = 93) and Horner syndrome (n = 7). The most prev... | Electronic clinical records at our veterinary referral hospital between April 2009 and November 2018 were searched for patients presented with cervical myelopathy secondary to an underlying suspected vertebral malformation/instability. Nine dogs met the inclusion criteria. Two dogs were diagnosed with atlantoaxial pseu... | 42305400 | Frontiers in veterinary science | [
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Title: Development of a low-cost external fixation system: an off-label solution for resource-limited settings. Background: External fixators are essential for the surgical management of long-bone fractures, particularly in resource-limited settings where access to commercial systems is often restricted by cost and log... | CG showed the highest stiffness (107.80 ± 14.12 N/mm), followed by SP (87.73 ± 17.92 N/mm), BKS (83.81 ± 10.01 N/mm), KS (49.84 ± 3.80 N/mm), and KT (46.66 ± 2.39 N/mm). Post-hoc analyses showed no significant differences between CG vs. SP and CG vs. BKS, whereas KT and KS were significantly less stiff. Elastic deforma... | The overall pathologic fracture rate was 37%. Pathologic fracture rate was significantly higher for dogs that received F-RT (5/6, 83%) compared to dogs that received C-RT (12/40, 30%, p = 0.021). In the 17 dogs that fractured, the overall median time to fracture was 57 days. For all dogs, the median progression free in... | The in vivo histology of the graft site after 3 years has shown that heterologous bone is a safe and valid choice as a scaffold for bone regeneration. Augmentation with NHA bone paste achieved good osteoinduction without an inflammatory reaction and good integration of the bone substitute insert. | The bone stresses were increasing in the models by using OMI covered with a revolving cap as compared with that in the conventional model (in which only the OMI was placed). However, no obvious differences in bone stresses were observed among the models with various types of angled revolving cap. The minimum principal ... | The Five-Implant model exhibited the most favorable biomechanical outcomes, demonstrating the lowest stress and strain values across prosthesis, implant components, and cortical bone. The Trefoil system showed the highest prosthetic stress (156.48 MPa axial; 119.32 MPa oblique) and abutment screw deformation, attribute... | Overall mean total costs for Tx and re-Tx of both WSLs and cavitations may sum up to 1718.91 Eur in the high-cost (GOZ 3.5) scenario for conventional MB cases, versus 19.94 Eur for lingually treated cases, given that renewal of simulated single-surface restorations takes place at 15-year intervals. When focussing on pa... | 42301298 | European journal of trauma and emergency surgery : official publication of the European Trauma Society | [
0.4733087420463562,
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Title: Efficacy of Vitex pseudo-negundo in a Bovine Mastitis Model Experimentally Induced by Staphylococcus aureus in Rats. Background: Mastitis is one of the most prevalent and economically significant diseases in dairy cattle, causing to inflammation of the mammary gland and reduced milk yield. This study investigate... | SA infection significantly increased mammary gland weight, total oxidative status (TOS) and bacterial load and induced tissue pathology, while decreasing total antioxidant status (TAS). C-reactive protein levels remained unchanged. VPN significantly improved mammary gland weight, TOS, TAS, bacterial load and histologic... | As a result, we showed that the assay for S. uberis detection demonstrated a specificity of 89.02%, a sensitivity of 43.59%, and an accuracy of 80.3%. In turn, the second variant - assay for Gram-positive cocci reached a specificity of 95.59%, a sensitivity of 43.28%, and an accuracy of 78.33%. Our study shows that EF-... | The overall prevalence of subclinical mastitis in she-camels was 10.6% (26/244), with no significant difference among the studied dairy farms. Risk factors that influenced the result of California Mastitis Test (CMT) included age and udder and leg hygiene. The study revealed that <i>S. aureus</i> was the most prevalent... | The overall bacteriological cure was observed in 10/40 (25%) cows in the P-PRP group, 9/28 (32.14%) animals in the SC group, 26/36 (72.22%) cows in the P-PRP+SC group, and 10/26 (38.46%) animals in the NCG. SCM caused by <i>S. aureus</i> (82/130, 63.08%), was cured in 6/24 (25%) cows treated with P-PRP, 7/24 (29.2%) co... | The results of Experiment 1 showed that administration of ATC improved growth performance and antioxidant functions in the serum and the liver, as well as immunoglobulin A, G, and M levels in rat serum, and it decreased the content of alanine aminotransferase, aspartate aminotransferase, triglyceride, cholesterol, low-... | Compared with autoclave sterilization, syringe filter sterilization resulted in less (p<0.05) phenolic and flavonoid contents. Against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, the filter sterilized herbal formula (<i>E. coli</i>: 65.9%-73%; <i>S. aureus</i>: 6.2%-18.1%) markedly reduced the antibacteri... | 42299878 | Veterinary medicine and science | [
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] |
Title: Microcomputed tomographic comparison of the bony structure of the canine and feline carpus. Background: Feline carpal joint injuries pose a significant clinical challenge due to their complex anatomy and the limited evidence available to guide treatment decisions. A detailed understanding of the osseous microarc... | All carpal bones exhibited a cancellous structure. Overall, cats had fewer but thicker trabeculae than the toy-dogs in the analysed areas of the carpus, which resulted in a greater trabecular distance in cats. Cats also had a higher bone volume (BV/TV) and thicker cortex. There were significant differences in structure... | The mandibular incisive canal was identified in 74.5% of patients and 60.6% of CBCT images. The mean length and diameter of the MIC were 13.7 ± 3.90 mm and 1.65 ± 0.55 mm, respectively. No statistically significant differences in MIC visibility were found across age groups or between edentulous and dentate patients. Me... | From 455,069 dogs under veterinary care, the one-year period prevalence for elbow joint disease diagnosis was 0.56% (95% CI: 0.53-0.60). Of 616 incident cases, the most common specific variants of elbow joint disease were osteoarthritis (<i>n</i> = 468, 75.97%), elbow dysplasia (190, 30.84%) and traumatic (41, 6.66%). ... | The most frequently diagnosed tarsal injuries were fracture of the central tarsal bone (CTB; 57.8%), calcaneal fracture (56.9%) and proximal intertarsal subluxation (34.5%). The most common injury combination was a CTB fracture with a calcaneal fracture (31.9%). In total 115 (99.1%) survived to discharge. Of these, 46 ... | All the dogs in group I were considered healthy. In these dogs, the mean radioulnar "step" height based on the X-ray examination was 0.85 ± 0.33 mm, the mean joint space width of the humeroulnar joint assessed in the computed tomography (CT) examination was 1.34 ± 0.34 mm, and the mean joint space width of the humerora... | More than 40 MIO articles have been published in the last 15 years, but most studies had small numbers, lacked control groups, and used limited outcome measures. Studies generally showed that MIO was feasible in dogs and cats with low complication rates. The current evidence does not demonstrate superior bone healing o... | 42298672 | Acta veterinaria Scandinavica | [
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] |
Title: Prevalence and Grade of Patellar Luxation in Cavalier King Charles Spaniels Attending Primary-Care Veterinary Practices in Australia. Background: To identify risk factors associated with the prevalence and grade of patellar luxation in Cavalier King Charles Spaniels (CKCSs) attending Australian veterinary practi... | The 10-year prevalence of patellar luxation in this study was 12.5% (95% confidence interval [CI], 0.12-0.13). The greatest risk of patellar luxation diagnosis was in neutered dogs (odds ratio (OR): 3.00; 95% CI, 1.97-4.71) and dogs weighing 11 to < 13 kg (OR: 2.52; 95% CI, 1.49-4.39). Dogs 10 years or older had the lo... | Weight distribution, joint range of motion at flexion and extension, thigh girth, digital thermography, and radiographic signs were collected. Data from different Clinical Metrology Instruments (CMI) were collected: Canine Brief Pain Inventory, Liverpool Osteoarthritis in Dogs, Canine Orthopedic Index, and the Hudson V... | Only 24/429 dogs met all enrollment criteria; 379/429 dogs lacked BALF collection. Diagnosis of b-AP differed using veterinary (79%) vs human (29%) medical criteria. Fever, band neutrophils and high radiographic scores were noted in dogs with and without b-AP. Lack of routine BALF collection hampers definitive recognit... | Multivariate models using the specimens showed that filter paper fixation of endoscopic samples resulted in a higher GSHA score than floating fixation in both dogs (ordinal odds ratio [OR]: 0.19; 95% confidence interval [CI]: 0.15-0.25) and cats (ordinal OR: 0.19; 95% CI: 0.13-0.29). In dogs, the scores were lower for ... | The study included a random sample of 22,333 dogs. The 1-year period prevalence for diagnosis with periodontal disease was 12.52% (95% CI: 12.09 to 12.97). Eighteen breeds showed increased odds compared with crossbred dogs. Breeds with the highest odds included Toy Poodle (odds ratio 3.97, 95% confidence intervals 2.21... | Thermal imaging revealed differences between the two groups of dogs, which were further supported by significantly higher temperatures in the El1 (lateral aspect of the stifle joint) and Bx1 (cranial aspect of the stifle joint) areas in the study group compared to the control group using a comparative analysis-two-samp... | 42295730 | Veterinary medicine and science | [
0.744225025177002,
0.4623982310295105,
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] |
Title: Synergistic antibacterial effect of CATH-2 and D-amino acids against mastitis causing gram-positive bacteria. Background: To effectively treat bacterial diseases caused by antibiotic-resistant strains, new antimicrobial agents are needed to overcome this resistance. This study explored whether the combination of... | The combination of CATH-2 and D-arginine showed strong synergistic antibacterial activity against Gram-positive bacteria, including all tested multidrug-resistant clinical <i>Staphylococcus aureus</i> isolates, in both LB medium (FIC = 0.37) and fresh raw milk (FIC < 0.12). No detectable cytotoxic effects on bovine udd... | Of the 200 positive CMT cattle, 24 animals were positive for <i>S. aureus</i> and confirmed using <i>16S rRNA</i> gene amplification. Statistical analysis showed that the phenotypic and genotypic tests of hemolysin genes were not significantly different (P>0.01). PCR analysis revealed the presence of <i>coa</i> and <i>... | The bacterial composition and diversity analysis of milk samples before and after probiotic administration was analyzed using 16S rRNA gene base metagenomic analysis and lactobacillus counts were also evaluated using Real time PCR. The results show that there was an increase in abundance of Proteobacteria and decrease ... | Of the 220 outlets, 74 (33.6%) were agro-veterinary shops and 146 (66.3%) retail pharmacies. Overall, 126 outlets did not stock veterinary medicines for mastitis. Among the 94 that did, 85 (90.4%) dispensed antibiotics and 9 (9.6%) dispensed other medicines without a prescription. Of the 134 veterinary medicines dispen... | Overall, 198 enterococcal isolates were identified from 2897 mastitis samples, including 137 (4.7%) <i>E. faecalis</i>, 50 (1.7%) <i>E. faecium</i> and 11 (0.4%) <i>E. hirae. E. faecalis, E. faecium</i> and <i>E. hirae</i> isolates showed high resistance to tetracycline (92.7%, 68.0%, 90.9%), followed by erythromycin (... | Our findings revealed that 73% (146/200) of the examined milk samples collected from dairy cows with clinical mastitis were infected with Streptococci species. Of these, 9.59% (14/146) were identified as S. agalactiae and categorized as MDR. S. agalactiae isolates expressed four virulence genes (Hyl, cylE, scpB, and lm... | 42291332 | Frontiers in cellular and infection microbiology | [
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] |
Title: Efficacy and safety of supplementation of Exclzyme Pet for the management of arthritis and inflammatory symptoms in dogs: a randomized, double-blind, placebo-controlled pilot trial. Background: A randomized, double-blind, placebo-controlled interventional pilot trial was conducted to evaluate the safety and effi... | Exclzyme Pet resulted in a statistically significant reduction in scores for lameness, weight bearing, joint mobility, willingness to hold up contralateral limb, and pain by 51.96, 46.94, 48.94, 58.0, and 55.56%, respectively and demonstrated clear superiority over placebo. The overall quality of life, mood, and mobili... | The median PFS was significantly longer in the RAB group compared to placebo (82 vs 21 days; P < .0001, HR 6.265 [95% CI 3.947-9.945]). The BORR for RAB-treated dogs was 73.2% (50.9% complete response [CR], 22.3% partial response [PR]) and 5.6% (0% CR, 5.6% PR) for placebo-treated dogs (P < .0001). One month after the ... | The review identified 27 relevant articles on the effects of ECSWT in horses, nine in dogs, but none in cats. Typically, ECSWT involved one to three treatment sessions at 1- to 3-week intervals. We identified studies on bone mass and bone healing, wound healing, navicular disease, ligament injury, desmitis, sesamoiditi... | Eleven dogs were enrolled. Stable disease was achieved in two of eight dogs available for response assessment. The median progression-free survival was 28 days (range: 4-93 days). The median stage III-specific survival time was 92 days. Adverse events were reported in four dogs; two dogs developed grade III or higher t... | A diagnosis of osteoarthritis was confirmed by a veterinarian in 38% (188 of 500) of dogs. Balance of sensitivity and specificity across the original group of nine screening questions was optimised to approximately 88 and 71%, respectively, after elimination of three questions. Pain measured by Helsinki Chronic Pain In... | Three days after surgery, grapiprant treated dogs had lower PSS compared to meloxicam treated dogs with a mean ± SD of 2.76 ± 0.18 vs 3.25 ± 0.23, respectively (difference of -0.49 [95% CI -0.94 to -0.04], P = .032). Pain Interference Score was also lower in grapiprant group at day 3 (4.11 ± 0.18 vs 4.69 ± 0.16 in melo... | 42290785 | Frontiers in veterinary science | [
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] |
Title: Topical betulinic acid for treatment of equine melanoma and sarcoid. Background: Betulinic acid, a natural pentacyclic triterpenoid, has demonstrated anti-inflammatory and anti-tumor properties in vitro, including activity against equine melanoma and sarcoid. However, there is limited in vivo evidence evaluating... | A total of 37 horses completed the study, including 16 with melanoma and 21 with sarcoid tumors. There were no statistically significant differences in tumor volume change between treatment and placebo groups for either tumor type. Tumor volume decreased in a proportion of cases across all groups. The treatment was wel... | Based on four books and a survey among veterinarians specialized in phytotherapy, four medicinal plants were chosen as the subject of this systematic review: Calendula officinalis L. (Marigold), Hypericum perforatum L. agg. (St. John's Wort), Matricaria chamomilla L. (syn. Matricaria recutita L., Chamomile) and Salvia ... | Forty-five compounds were identified in a primary screening that showed tumor-selective inhibitory activity against lymphoid tumor cells. Based on the literature, five compounds (artesunate, niclosamide, pentamidine, itraconazole, and dronedarone) were selected for secondary screening. All the five compounds exhibited ... | Treatment of <i>L. major</i> infected BALB/c mice with nanoliposomal curcumin led to a reduction in the kinetic of the skin lesion size development. The semi quantitative PCR analysis of DNA extracted from the lesions showed reduction of parasite burden. The most effective treatment could be found in 80 μM nanoliposoma... | A total of 152 horses was included. The most common signs were poor performance (68%), nonspecific pain (43%), and irritation/aggression (41%). Intestinal signs were observed in 63% of horses. Sixty-six percent of horses had ultrasonographic changes in the small intestine, and 37% had gastric ulcers. Orthopaedic examin... | A single TT treatment resulted in 75% complete response (CR) (95% confidence interval [CI] = 61-86) by 28 days, with no recurrence in 93% (95% CI = 82-97) of dogs by 84 days. Eight TT-treated dogs that did not achieve CR in phase 1 achieved CR after retreatment, increasing the overall CR to 88% (95% CI = 77-93). Contro... | 42290780 | Frontiers in veterinary science | [
0.5024169683456421,
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Title: Variations in the management of canine osteoarthritis: a cross-sectional survey of veterinary practices. Background: There is limited data on how veterinarians implement multimodal therapies for managing canine osteoarthritis (OA). The primary aim of this study was to describe how OA is managed by veterinarians ... | 373 responses were analyzed. Non-steroidal anti-inflammatory drugs (NSAIDs) were the most prescribed drug class, and gabapentin, bedinvetmab, and polysulfated glycosaminoglycan (Adequan<sup>®</sup>) were the most prescribed non-NSAID medications. The most used nutraceutical and non-pharmacologic treatments were omega-3... | Twenty dogs were enrolled in the study. In both groups there was an increasing values of ground reaction forces. These results might indicate that both nutraceutical products determined a better condition in terms of pain feeling but that effect is much more visible after 60 days from the end of the administration in t... | Dogs treated with four weekly injections of HA or two biweekly injections of HA-PRP were significantly (p < 0.05) better than dogs treated with four weekly injections of saline at 2-, 4-, and 12-week time points based on a comfortable range of motion (CROM) and clinical lameness score. Gait analysis measuring symmetry ... | Ten dogs with clinical signs of SA, nine with osteoarthritis (OA, control group) and nine with clinical signs of immune-mediated polyarthritis (IMPA, second control group) were examined. Bacterial culture was positive in seven of 10 dogs with clinical SA, of which only two were positive by 16S rRNA PCR. The sensitivity... | Veterinarians and students both reported feeling more blame, frustration, and disgust toward dogs with obesity and their owners than toward lean dogs and their owners (p values < 0.001). Interactions between dog and owner body weight emerged for perceived causes of obesity, such that owners with obesity were perceived ... | The sample was composed of 92 males and 73 females, with a mean age of 5.2 ± 3.2 years. Four main dog breeds were represented, 60 Belgian Malinois Shepherd Dogs, 52 German Shepherd Dogs, 29 Labrador Retrievers, and 14 Dutch Shepherd Dog. A prevalence of diarrhea of 10.6% was determined, with 4% of dogs having liquid di... | 42290771 | Frontiers in veterinary science | [
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] |
Title: Multi-target synergistic mechanisms of flavonoid compounds from traditional Chinese medicine in non-alcoholic fatty liver disease: insights for human and veterinary medicine. Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disorder characterized by dysregulated hepatic lipid me... | Existing research evidence demonstrates that TCM flavonoids improve NAFLD through multiple core regulatory pathways. These compounds reverse hepatic lipid metabolism disorders by activating the <i>AMPK/SIRT1</i> and <i>PPARα</i> signaling pathways, inhibit lipogenesis by suppressing the key lipogenic factor <i>SREBP-1c... | The present study revealed that MGN rats treated with ILQ showed significantly ameliorated kidney dysfunction and histopathological changes in kidneys. ILQ treated MGN rats alleviated the oxidative stress and were presented with increased anti-oxidative status in kidneys. Furthermore, ILQ treatment to MGN rats showed a... | We established an in vitro bovine fatty liver cell model and conducted a comprehensive analysis of cells treated with TMAO using high-throughput omics sequencing technologies. Bioinformatics methods were employed to delve into the regulatory effects on lipid metabolism, and several key genes were validated through RT-q... | GLU and FRU concentrations in the RYGB group were significantly lower than in diabetic controls (<i>p</i> < 0.05), remaining comparable to the insulin-treated group (<i>p</i> > 0.05). Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were significantly reduced post-RYGB (<i>p</i> < 0.05), c... | Results showed that supplementation effectively reduced proteinuria, blood urea, and phosphorus levels, stabilized creatinine and SDMA, and maintained blood pressure. It also improved markers of systemic inflammation and oxidative stress. The once-daily dosage simplified administration and was especially beneficial for... | K/X significantly (P < 0.05) increased blood glucose at 30, 60, 90, and 120 min, decreased insulin levels, and induced oxidative stress, which was accompanied by an increase in pro-inflammatory cytokines. Berberine (5 and 20 mg/kg) and yohimbine (2 mg/kg) significantly reduced blood glucose and increased insulin levels... | 42283012 | Frontiers in veterinary science | [
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0.4392980933189392,
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] |
Title: Combined Effects of Arsenic and Cadmium With Selenium on Oxidative Stress Indicators in Goldfish: Implications for Veterinary Toxicology. Background: The individual and combined effects of toxic heavy metals, including arsenic (As) and cadmium (Cd) and their interactions with selenium (Se), play a crucial role i... | Body weight increased in all treatment groups compared to initial values. Co-exposure to Se significantly reduced As accumulation, with tissue concentrations decreasing from 0.16 ± 0.02 mg/kg in the As group to 0.10 ± 0.009 mg/kg in the combined exposure groups (approximately 62 % reduction; p < 0.05). In contrast, Cd ... | Hematological reference indices were generated for the aforementioned equine breeds in Western Libya. The equine hematological profile was variable according to some individual and management factors. In addition, the significant effects of those factors were usually restricted to erythrocyte- and platelets (PLTs)-rela... | All short- (C2-C5) and medium-chain (C6-C12) AC in blood differed significantly (<i>p</i> < 0.008) between horses with AM and controls, except for C5:1 (<i>p</i> = 0.45) and C5OH + C4DC (<i>p</i> = 0.06). In AM survivors the AC concentrations decreased over time but were still partially elevated after 7 days. 14/62 (23... | Iron accumulated within chondrocytes, which was associated with programmed cell death through chondroptosis. Iron treatment increased the release of sulfated glycosaminoglycans (sGAG), a component of the extracellular matrix, into the medium (p=0.0189). This was dependent on the presence of viable chondrocytes and was ... | The deltamethrin significantly increased AST, ALT, ALP, and the level of ROS level at the end of 1 and 24 <i>hr</i> after treatment; while the LDH level and GSH content were decreased. Mice in the deltamethrin treated group had a higher liver/body weight ratio than in other treated groups after 24 <i>hr</i>. On the oth... | Seven days of treatment resulted in a mycophenolic acid (MPA) area under the curve (AUC<sub>0-12</sub> ) of 12 594 h × ng/mL (8567-19 488 h × ng/mL) and terminal half-life (T<sub>1/2</sub> ) of 11.3 hours (7.5-15.9 hours), yielding minor metabolite accumulation in all horses treated. Salmonellosis was detected in the f... | 42281510 | Veterinary medicine and science | [
0.7645283341407776,
0.4131941497325897,
0.3718166649341583,
0.36468198895454407,
0.36226582527160645,
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] |
Title: Early Protraction Facemask Followed by Fixed Appliance Therapy in a Growing Patient With Skeletal Class III Malocclusion: A Case Report. Background: Skeletal Class III malocclusion remains a significant orthodontic challenge because of its multifactorial aetiology, strong genetic influence, and the unpredictabil... | This case highlights that biologically timed protraction facemask therapy, even when initiated beyond the conventional early age, combined with careful case selection and comprehensive fixed appliance treatment, may achieve favourable functional and aesthetic outcomes in selected growing patients with borderline skelet... | After applying significantly different traction forces to the maxillary tissues on both sides of the patient, the patient was treated with appropriate traction correction, orthodontic treatment and moderate traction on the facial arch to effectively reduce the recurrence of the disease after surgery. Compared with the ... | This study demonstrated that after occlusal adjustment, the maxilla showed significant increases in intermolar width, intercanine width, and arch Circumference compared with the controls after six months post-debonding (p = 0.009, 0.011, 0.041). In the mandible, the changes in intermolar width and arch Circumference we... | These results suggest that surgically assisted and implant anchored-orthodontic approaches might be effective for the correction of such malocclusions. | Higher stresses were observed in mandibular dentition with the inter-radicular implant system. The amount of von Mises stress was higher for cortical bone (85.66MPa) and cancellous bone (3.64MPa) in Case 2, in comparison to cortical bone (41.93MPa) and cancellous bone (3.43MPa) in Case 1. The amount of arch distalizati... | A statistically significant increase during treatment was observed for all maxillary teeth transversal distances (p< 0.05). In turn, a significant reduction was observed in the long term (p< 0.05). For the mandibular teeth, canine transversal distance presented statistically significant constriction in the retention pe... | 42272660 | Case reports in dentistry | [
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0.5609597563743591
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Title: Analytical validation, reference interval determination, and diagnostic performance of plasma symmetric dimethylarginine in cattle. Background: The efficacy of serum urea and creatinine concentrations in the diagnosis of kidney disease in cattle is limited because of their low sensitivity and specificity. Serum ... | The SDMA measurements showed acceptable analytical performance. The reference interval was 60-160 μg/L. No significant differences were found according to sex, breed, or food supply. Using the upper limit of the reference interval (160 μg/L) as the cut-off, sensitivity and specificity were 0.85 and 0.98, respectively. ... | Plasma samples measured with the CA showed on average 2.3 (EDTA) and 2.5 (LH) times higher Hp concentrations compared with serum, whereas no differences were seen with the ELISA results between sample types. Based on a clinical cut-off value, both methods differentiated sick from healthy cows. Haptoglobin measurements ... | A higher US chronic kidney disease (US-CKD) score of the kidney contralateral to the UO was associated with long-term IRIS stages III and IV. It also appeared as a fair discriminator of long-term IRIS stage IV, with an area under the curve of 0.74. The optimal cutoff value for accurately identifying cats with long-term... | Ninety CE dogs were included. Fifty-two dogs had mild-to-severely decreased MCS and 38 dogs showed altered urinary parameters. No significant associations were found between CCECAI and altered urinary parameters. No significant association was found between PLE dogs and altered urinary parameters. PLE dogs showed highe... | Fifty-eight percent (n = 31/53) of proteinuric cats had ICGN and 74% (n = 31/42) of cats with PLN had ICGN. Cats with glomerular diseases other than ICGN had a higher median urine protein:creatinine ratio than ICGN cats (14.5 vs 6.5; <i>P</i> <0.001). Onset of PLN occurred at a young age; median age at diagnosis was 3.... | We found detectable concentrations of SAA, Hp and LBP in pharyngeal swabs from calves, as well as in TA and serum. There were no biologically interesting correlations between the SAA concentrations in serum and TA or pharyngeal swabs. This also applied to Hp and LBP concentrations in serum and TA or pharyngeal swabs. S... | 42263210 | Journal of veterinary internal medicine | [
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] |
Title: Validation of a Pregnancy-Associated Glycoprotein-Based Lateral Flow Assay for Early Pregnancy Detection in Goats. Background: The significant cross-reactivity between bovine, ovine, and caprine pregnancy-associated glycoproteins (PAGs) enables the adaptation of bovine-specific diagnostics for use in other rumin... | Results indicated that on Day 21, AOFPT sensitivity, specificity, positive predictive value, and negative predictive value were 79.4%, 93.8%, 98.2%, and 51.7%, respectively. By Day 28, these metrics reached 100%, 81.3%, 95.8%, and 100%. Statistical agreement between AOFPT and the reference method was K = 0.55 (82.14%) ... | Medical records of 187 goats and 434 sheep were included in the analysis of this study. Females were significantly more represented in the study population for goats and sheep, 87.70% and 84.10%, respectively. The age of animals ranged between 1 day and 9 years in goats and 1 day and 7 years in sheep. In both goats and... | We found detectable concentrations of SAA, Hp and LBP in pharyngeal swabs from calves, as well as in TA and serum. There were no biologically interesting correlations between the SAA concentrations in serum and TA or pharyngeal swabs. This also applied to Hp and LBP concentrations in serum and TA or pharyngeal swabs. S... | The RIs for cardiac serum biomarkers included in the present study were generally within the reference range provided for sheep with slight variations which might be attributed to physiological adaptation to harsh desert climate. The Na<sup>+</sup> significantly (<i>p</i> ≤ 0.05) predicted AST (adj. <i>r</i>-square = 0... | Pathogenic <i>Leptospira</i> spp. DNA was detected by lip<i>L32</i> PCR in at least one anatomical site in 55% (22/40) of animals. The highest positivity rate was observed in UB (20/40; 50%), whereas AUH (7.5%), BUH (0%), and OVID (2.5%) showed no or minimal detection. The findings demonstrate that pathogenic <i>Leptos... | Of the 368 proteins, 84 were detected in CSF and 146 in serum. Eighteen of 84 proteins in CSF and 30/146 in serum were differentially abundant among the 3 groups, after correction for multiple testing. Modeling indicated that a 2-protein test using CSF had the highest accuracy for discriminating among all 3 groups. Cer... | 42262719 | Veterinary medicine and science | [
0.7194649577140808,
0.5547218918800354,
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0.45911213755607605,
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] |
Title: Effect of occlusal adjustment on post-orthodontic relapse in extraction cases: a randomized clinical trial. Background: Maintaining post-treatment occlusal stability remains a major challenge in orthodontics. Premature occlusal contacts may contribute to relapse. This study aimed to evaluate the effect of select... | This study demonstrated that after occlusal adjustment, the maxilla showed significant increases in intermolar width, intercanine width, and arch Circumference compared with the controls after six months post-debonding (p = 0.009, 0.011, 0.041). In the mandible, the changes in intermolar width and arch Circumference we... | Forty subjects (mean age 13.7 ± 2.1 years) with 43 IMC and 47 incisors with CIRR were recruited. The IMC either spontaneously erupted, were surgically exposed or surgically removed. Thirty-four of the patients were treated with a fixed appliance and six had no orthodontic treatment. The follow-up range was 5.5-14.6 yea... | Radiograph revealed all of the tumors before orthodontic treatment. CBCT is appropriate to use for surgical approach, and it minimizes complication. An OPG is less costly compared to CBCT. Odontomas were treated by surgical removal because the tumor blocked the pathway of tooth eruption and medialized or distalized tee... | Mean rotational correction was 14.05° during posttreatment. Mean relapse at 1-year follow-up was 1.1° (10.8%). More than half (<i>n</i> = 52, 57.8%) of teeth were categorized as having unnoticeable relapse (0°). Of the remaining teeth, 31 (34.5%) had barely noticeable relapse (1°-3°), 6 (6.6%) had noticeable relapse (4... | Preoperative orthodontic decompensation determines the discrepancy and maximizes mandible repositioning. The technique improves surgical planning and therapy outcomes. This case report describes the "Hunsuck modification fracture pattern," which is a type of fracture that has a horizontal cut behind the lingula and a v... | After controlling for confounding variables, there was a 1.64 mm (95% confidence interval [CI], 0.30, 2.98 mm) median between-groups difference among patients who utilized vacuum-formed retainers (VFRs). The treatment groups did not vary in inter-canine and intermolar widths (<i>P</i> = 0.52; 95% CI, -1.07, 1.05), arch... | 42256689 | Revista cientifica odontologica (Universidad Cientifica del Sur) | [
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0.5545221567153931,
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] |
Title: Aortic root abscess in a high-risk case requiring modified hemi-UFO procedure with custom-made pericardial conduit - a case report. Background: The UFO procedure is an established surgical technique to treat extensive endocarditis of the aortic or mitral valve with involvement of the intervalvular fibrous body (... | We showed a successful surgical treatment of aortic prosthesis endocarditis with involvement of the IVFB. We were able to perform a radical resection of the infected tissue, reconstruct and replaced all sacrificed tissue with biological tissue and preserved the native mitral valve in a modified hemi-UFO procedure. | There were 467 patients who underwent 686 PVIs (665 SPVI [96.9%] and 21 PPVI [3.1%]). The surgical prostheses were all biologic valved conduits: aortic homograft (118, 17.7%), pulmonary homograft (312, 46.9%) and Contegra (235, 35.3%). The percutaneous prostheses were exclusively Melody valves (21, 100.0%). Incidence o... | The patient recovered from surgery and discharged but died 10 months after surgery because of complete resection was impossible and adjuvant therapy was not performed. Resection of primary cardiac angiosarcomas should be integrated with a combination of chemotherapy, radiotherapy, and targeted therapy based on tumor ce... | Endovascular repair requires suitable anatomy, including adequate landing zones and small neck size, which were lacking here. Direct surgical patch repair offers a safe, effective, and less-invasive alternative to full aortic replacement, especially in septic, frail patients. Multidisciplinary heart team discussion is ... | Cardiac angiosarcomas can be large and challenging to resect. Aggressive surgical resection may prolong survival, even with positive margins. Extensive surgical resection may improve survival for cardiac angiosarcoma with locally extensive and metastatic disease. | In the RG, the early mortality rate was 4.2% (8/192). In the BG, the early mortality rate was 5.1% (16/316). There were no significant differences between groups. The incidence of postoperative renal failure in the BG was significantly higher than that in the RG. The mean follow-up time was 2.93 years (standard deviati... | 42249393 | Journal of cardiothoracic surgery | [
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] |
Title: Prevalence of tick-borne pathogens in ixodid ticks collected from domestic animals in southeast Iran. Background: Tick-borne pathogens (TBPs) pose a significant threat to livestock production in Kerman Province, Iran. Despite the high prevalence of TBPs, our understanding of specific pathogens circulating within... | In this study, 707 ixodid ticks was collected included <i>Hyalomma marginatum marginatum</i> (70.7%, 108 pools) and <i>Rhipicephalus linnaei</i> (29.2%, 27 pools). Based on molecular analysis, <i>Rickettsia</i> spp., <i>Ehrlichia</i> spp, <i>C. burnetii</i> and <i>Bartonella</i> spp. were detected in 55.5%, 9.6%, 8.1% ... | The prevalence and case fatality of ehrlichiosis were 6.9% and 47.1%, respectively. Dogs in rural areas had 5.8 times higher odds of ehrlichiosis (odd ratio, OR: 5.84; 95% CI: 1.72-19.89) compared to urban areas. Dogs with access to other dogs had 5.14 times higher odds of ehrlichiosis (OR: 5.14; 95% CI: 1.63-16.27) th... | <i>T. vivax</i> was detected in 0.40% (1/246) of the samples, while <i>B. bigemina</i> and <i>B. bovis</i> were detected in 20.62% (33/160) and 11.87% (19/160) of the samples, respectively. It was found that there was a reduction in mean corpuscular volume in animals that presented with co-infection and those infected ... | With the spread of both ticks and TBEV, infection with TBEV should be given further consideration as a potential differential diagnosis in cases of foetal death in dogs. | Apparent and true seroprevalence were 22% (95% CI 18%-27%) and 11% (credible interval with 95% probability 0.6%-21%) respectively. We estimate that two-thirds of positive samples are false positive in southern Belgium, with one in five of tested horses potentially misdiagnosed as infected. Around 5% of antimicrobial us... | The gut of ticks that received no antibiotic but were treated with M. anisopliae exhibited lower bacterial diversity and a higher occurrence of Coxiella species. The Simpson diversity index and Pielou equability coefficient were higher in the gut bacterial community when R. microplus were fed with tetracycline and fung... | 42238846 | New microbes and new infections | [
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] |
Title: Understanding antibiotic decision-making for bovine respiratory disease: a survey of UK farm veterinarians. Background: Bovine Respiratory Disease (BRD) is a major cause of morbidity and mortality in young calves and a major driver of antibiotic use in the United Kingdom (UK), making veterinary decision-making c... | For BRD diagnosis in calves, clinical examination (36.8%), necropsy (33.7%), and rectal temperature (31.6%) were the tools most regarded as extremely important. Oxytetracycline was the most commonly used primary antibiotic (52.6%), tulathromycin was the secondary option (38.9%), and NSAIDs were represented as the most ... | A total of 152 calves were recruited, with a relative BRD prevalence of 49 per cent (74/152). Thirty-two calves required a secondary treatment (due to continued fever), causing exclusion from statistical analysis of the change in ultrasound score and resulting in the study being underpowered for detecting statistical s... | The cure rate in cows treated with phenytoin (86.66%) on day 28 was significantly improved compared to cows treated with either chlortetracycline (60%) or normal saline (6.66 %). Our findings highlight the superiority of phenytoin over the commonly used antibacterial agent, chlortetracycline, in the topical treatment o... | Welsh equine owners regarded their horses as members of the family (84.8%). Most sourced antibiotics from their vet (68.9%) with a minority (5.1%) never having done so or having used antibiotics left over (16.6%) and 13.6% would consider changing veterinary practice if they did not receive antibiotics when they request... | Out of 453 veterinarians, 71.74% stated handling of the animals on day-to-day basis and 28.25% were engaged in administration activities. The veterinarians ranked foot-and-mouth disease and brucellosis at the first and fourth ranks among the list of ten economic impacted diseases in the country. A significant associati... | Taxonomic and functional composition of the URT microbiome in suckling and weaned beef calves did not change significantly when serially sampled over a one-month period. Subtle temporal changes in the URT microbiome composition were observed in weaned + transport calves. Total bacterial density was lower (p < 0.05) on ... | 42238792 | Frontiers in veterinary science | [
0.7063141465187073,
0.537114679813385,
0.5209962725639343,
0.5678227543830872,
0.5323116183280945,
0.5590190291404724
] |
Title: Discovery of novel biomarkers associated with myocardial fibrosis in chimpanzees (<i>Pan troglodytes</i>). Background: Idiopathic myocardial fibrosis (IMF) is a prevalent and life-threatening condition in captive chimpanzees (<i>Pan troglodytes</i>). Ante-mortem diagnosis remains challenging due to the limitatio... | In the discovery phase, ICAM-2, AXL, and PECAM-1 were significantly elevated in IMF-affected animals. During ELISA validation, circulating ICAM-2 remained significantly elevated in the IMF cohort (<i>p</i> = 0.010, Cohen's <i>d</i> = 0.91). No significant association was detected with subject age or the time interval b... | FGF4L2 genotype was defined in 89 FCE cases. Fibrocartilaginous embolic myelopathy was present in 22 dogs from FGF4L2-segregating breeds with allele frequencies of ≥5%; however, all dogs were wild type. Two Labrador retrievers with FCE carried FGF4L2 alleles. Frequency of the FGF4L2 allele was significantly (P < .001) ... | Of the 368 proteins, 84 were detected in CSF and 146 in serum. Eighteen of 84 proteins in CSF and 30/146 in serum were differentially abundant among the 3 groups, after correction for multiple testing. Modeling indicated that a 2-protein test using CSF had the highest accuracy for discriminating among all 3 groups. Cer... | This review article provides a comprehensive overview of the etiological factors, epidemiology, clinical manifestations, and challenges associated with FIP. Additionally, it underscores the critical need for further research to enhance diagnostic capabilities and develop effective therapeutic interventions. By shedding... | A panel of 554 serum samples of pigs, goats, sheep, and cattle collected throughout Guinea from 2017 to 2019 where tested by RTB and ELISA tests in parallel at the Institut Pasteur de Guinée (Conakry) and the Brucellosis WOAH/EU Reference Laboratory of the French Agency for Food, Environmental and Occupational Health &... | The sensitivity (S) of both ICTs for human samples (Ad-bio Leishmania IgG/IgM Combo Rapid Test and Kalazar Detect™) was 91.5% and specificity (E) were 93.2 and 89.2% respectively, while for the ICTs tested on canine samples (Kalazar Detect™ Rapid Test, Canine and DPP® CVL rapid test) we found S values between 82.9 and ... | 42238790 | Frontiers in veterinary science | [
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0.43467673659324646,
0.44416168332099915,
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] |
Title: Protocol Optimization for Exosome Production From Umbilical Cord Mesenchymal Stem Cells: A Step Toward Clinical Translation. Background: Exosomes, nano-scale extracellular vesicles, hold transformative potential in regenerative medicine and neurodegenerative disease treatment. However, inconsistent isolation met... | TEM confirmed exosome integrity with spherical or cup-shaped morphology and intact bilayers. DLS showed a monodisperse population (121.3±23.7 nm, polydispersity index [PDI] <0.3) and stable zeta potential (-37.3 to -43.8 mV). The BCA assay quantified exosomal protein at 1098.2 μg/mL, surpassing conventional yields. Wes... | Exo<sub>Av</sub>-IL-1RA and Exo<sub>CPC</sub>-IL-1RA, penetrated and retained in the full-thickness of early-stage arthritic cartilage explants. Free IL-1RA failed to suppress IL-1α-induced catabolism over the culture period. In contrast, Exo<sub>CPC</sub>-IL-1RA significantly suppressed cytokine-induced glycosaminogly... | MSC homing enhanced the fraction of Tie2-positive IVD cells in bovine and human IVD samples. Furthermore, a proliferative response and lower fraction of dead cells were observed after MSC homing in both bovine and human IVD tissues. Our findings indicate that MSC homing enhances the survival and regenerative capability... | No qualitative differences in three-dimensional tendon constructs generated from adult, fetal and ESCs were found using histological and morphological analysis. However, genome-wide transcriptomic analysis using RNA sequencing revealed that ESC-derived tenocytes' transcriptomic profile more closely resembled fetal teno... | Encapsulation of the eqSMMSCs protected the cells from the inflammatory media compared to the monolayer cultures. EVs were found in higher concentrations in the 3D-OA cultures. Additionally, higher expressions of microRNA-140 were observed in the cells of the 3D-OA group at 24 and 72 h, whereas microRNA-140 expressions... | The prepared AuNCs and MSNs possessed good properties as previously reported. The fluorescence intensity and CT value of the AuNCs were enhanced after being enriched with MSNs. The nanoparticles were both non-cytotoxic. Confocal laser scanning microscopy and flow cytometry indicated that MSN@AuNCs in CAL-27 cells showe... | 42238750 | Basic and clinical neuroscience | [
0.7163615226745605,
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0.3451946973800659,
0.34357544779777527,
0.40105143189430237,
0.4123004674911499
] |
Title: Effect of regenerating toothpastes on abrasion of eroded enamel and dentin: An in vitro study. Background: This in vitro study evaluated the effect of self-declared enamel regenerating toothpastes on advanced erosive tooth lesions. | Brushing with Dentalclean (3.67 [0.47] μm) induced the greatest enamel wear (SD), followed by Sensodyne (2.99 [0.56] μm). Both were significantly different (SD) from Elmex (1.85 [0.38] μm) (<i>P</i> < .0001), which did not differ from erosion only (1.98 [0.57] μm). For dentin, brushing with Dentalclean (2.95 [0.60] μm)... | Gels containing 0.1 and 1.0 mg/mL CaneCPI-5 significantly reduced %SHC compared to the other treatments (p<0.05). Treated enamel showed significantly lower γS than control, without changes in the apolar component (γSLW), but the polar component (γSAB=Lewis acid-base) became more negative (p<0.01). Moreover, CaneCPI-5 t... | The overall highest mean wear of enamel (9.88 ± 1.73 µm) was observed in the control group (G1), where no fluoride gel was applied. It was significantly higher (p < 0.001) compared to all other groups. G2 (5.03 ± 1.43 µm), G3 (5.47 ± 0.63 µm, p = 0.918) and G4 (5.14 ± 0.82 µm, p > 0.999) showed the overall best protect... | At each evaluation period, all active mouthwashes produced statistically significantly greater stain reduction than the placebo (p < 0.05). The mean percentage stain reduction differed significantly (p < 0.01) between time points (1, 4, 8 weeks) with 6M-GN-ENZ (38.96%, 47.58%, 52.35%) and GN-ENZ (28.69%, 37.95%, 39.95%... | At 14 days post-bleaching, GNC promoted the lowest ΔWID and ΔE00 (p<0.05), and no differences were found between GPC and the remaining groups submitted to the antioxidant agents (p>0.05). QC_1% and QUI_10% exhibited acidic pH levels (3.64 and 4.75, respectively), whereas TOC_10% and GS_5% exhibited alkaline pH (7.07 an... | GLU significantly reduced the dentin permeability and occluded the dentinal tubules when 2% BSA was used as perfusion fluid. RD significantly reduced dentin permeability and occluded the tubules, but permeability rebounded after AS immersion. GLU significantly decreased cell viability, but RD was non-cytotoxic. In vitr... | 42238122 | JADA foundational science | [
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] |
Title: Accuracy and bias of high-frequency ultrasonography in measuring white spot lesion depth: an in-vitro comparison with micro-CT. Background: This in vitro study aimed to evaluate the accuracy and bias of Ultrasound (US) in measuring the depth of white spot lesions (WSLs), in comparison to micro-CT (µ-CT). | Mean lesion depths in the shallow WSLs group were 138.3±17.8 μm (µ-CT) and 169.2 ± 37.8 μm (US), while in the deep WSLs group, depths averaged 299.9 ± 47.7 μm (µ-CT) and 309.3 ± 75.7 μm (US). The absolute mean differences between µ-CT and US were significantly different from zero (p < 0.001). US consistently overestima... | Fourteen dogs with epididymitis were included, and the condition was unilateral in 11 dogs (eight left-sided) and bilateral in three. On B-mode ultrasound the epididymal tail was the most frequently affected portion. Other frequent findings included epididymal enlargement, capsular irregularity, and inhomogeneous echot... | This case report contributes to the clinicopathological and imaging characterization of pulmonary alveolar microlithiasis in dogs. In this species, the diagnosis of PAM should be considered when CT features evidence a reticular pattern with ground glass opacity and the presence of an elevated number and size of calcifi... | In total, 138 dogs were presumptively diagnosed with MUO. The most common location for lesions identified on MRI were the white matter tracts of the corona radiata and corpus callosum, followed by the frontal, sensorimotor and temporal cortices. Lower T2 lesion load (<i>p</i> = 0.006, OR = 0.942, CI = 0.902-0.983) was ... | A total of 6 volunteers (3 males and 3 females) with a mean age of 39.2 (±16) years were included. While the thickness of the fibromucosa decreased along the anterior area, the distance from the cementoenamel junction to the position of the artery was generally maintained up to the canine position, where it was found t... | The CNN6-Fbank model achieved an accuracy of 94.12% [95% confidence interval (CI): 94.11-93.12], specificity of 97.30% (95% CI: 97.30-97.34), sensitivity of 94.12% (95% CI: 93.74-94.50), precision of 92.63% (95% CI: 92.29-92.97), and F1 score of 93.32% (95% CI: 93.05-93.59), outperforming the PaSST and ResNet38 models ... | 42234205 | Clinical oral investigations | [
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] |
Title: Impact of Platelet-Rich Plasma on the Rate of Canine Retraction: A Split-Mouth Randomized Clinical Trial. Background: The main concern of patients undergoing orthodontic treatment is the prolonged duration of treatment. Various measures have been introduced in the field of orthodontics to accelerate tooth moveme... | The results showed the mean rate of canine retraction in group PRP was 5.66±0.51, 4.50±0.54, and 3.16±0.40, respectively, at 0 day, 21 days, and 42 days, with a statistically significant difference between the control group (p<0.001). Increased tooth movement was observed on the experimental side compared to the contro... | For the maxillary canine, there was no significant difference between the PA and C groups for all types of tooth movement except rotation. Specifically, the PA exhibited a significantly less difference in distal-in rotation compared to the control group (APa-VPa -3.54°/AC-VC -11.57°). Similarly, the RMSE of PA demonstr... | A statistically significant reduction in bone density was observed at the center of resistance of canine on the experimental site (after MOPs) at 1 week and 3 weeks (T0-T1 = 0.000,0.115; T1-T2 = 0.0025,0.0117), whereas a statistically non-significant difference was found 1 week before and 3 weeks later in the control g... | Result of the intra-examiner reliability using ICC is more than 0.97 (<i>P</i> < 0.001), indicating excellent repeatability and reliability of the measurements. The baseline characteristics between groups were similar (<i>P</i> > 0.05). A statistically significant difference in the rate of canine retraction on the MOP ... | The reported outcomes revealed a significant increase in the amount of canine retraction, canine tipping, as well as root resorption scores on the experimental sides in both groups SAG and MAG post-retraction (p < 0.001). However, upon comparing the experimental sides in both groups, non-significant differences have be... | No statistically significant difference was observed in the rates of tooth movement between the MOP and the control sides at all-time points (first month: <i>P</i> = 0.77; mean difference, 0.2 mm; 95% CI, -0.13, 0.18 mm; second month: <i>P</i> = 0.50; mean difference, -0.08 mm; 95% CI, -0.33, 0.16 mm; third month: <i>P... | 42231989 | Cureus | [
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0.6458851099014282,
0.6102613210678101,
0.5924472808837891,
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] |
Title: Two-Port Totally Laparoscopic Colonopexy for the Treatment of Recurrent Rectal Prolapse in a Cat: A Case Report. Background: To describe a modified totally laparoscopic colonopexy technique performed using only two ports for the treatment of recurrent rectal prolapse in a cat, aimed at minimizing surgical access... | The procedure was completed without intraoperative complications, with a total surgical time of 43 min. Postoperative handling and medical management were limited due to the patient's aggressive behaviour. The cat resumed voluntary feeding within 6 h postoperatively and showed no signs of tenesmus or recurrence of rect... | Twenty-one cats were included. Nine cats (42.9%) died and 12 (57.1%) recovered. Based on ultrasonography, the duodenum and jejunum showed thinning of the mucosal layer in 70.6% and 66.6% of cats, thickening of the muscular layer in 52.9% and 57.1% of cats, and hyperechogenicity of the mucosa in 41.2% and 33.3%. Jejunal... | The final logistic regression form demonstrated that the statistical test, Hosmer and Lemeshow's goodness of fit, indicates a significant result (<i>χ</i><sup>2</sup> = 8.91). Body score was the potential risk factor for the occurrence of RP in calves. Medicinal management along with dietary modification was sufficient... | Mild post-operative deterioration was observed in all dogs. Follow-up from 7 to 36 months indicated a satisfactory outcome. We conclude that the closure of durotomy has similar short-term and long-term outcomes compared to the previous reported studies. These results suggest that the closure of durotomy is a viable tec... | The present report describes the successful use of a pleural port to treat pyothorax in one cat. This is the first time such a device has been reported for the treatment of pyothorax. | All of the animals underwent laparotomy with retroperitoneal access. Two received an autologous peritoneal patch and 16 received a bovine pericardial patch. Three animals underwent single suprarenal clamping, while 15 underwent sequential clamping. There were no differences in operative time (p<i>=</i>0.207) or total c... | 42227076 | Veterinary medicine and science | [
0.8427774310112,
0.4096260666847229,
0.43580156564712524,
0.43217578530311584,
0.4508446156978607,
0.4178107678890228
] |
Title: Metabolic effects and pharmacokinetics of oral cannabidiol (CBD) in Connemara ponies following 21 days of treatment. Background: Cannabidiol (CBD) has gained interest in equine medicine due to its potential therapeutic effects. Preclinical studies suggest that CBD may influence metabolic pathways relevant to met... | CBD did not significantly affect body weight, BCS, CNS, blood glucose, or triglycerides. Insulin concentrations during the oral sugar test increased significantly in the CBD group (mean change: 10.74 ± 5.19 μIU/mL; <i>p</i> = 0.046), whereas no significant change was observed in control (-6.21 ± 6.14 μIU/mL; <i>p</i> =... | Hematological reference indices were generated for the aforementioned equine breeds in Western Libya. The equine hematological profile was variable according to some individual and management factors. In addition, the significant effects of those factors were usually restricted to erythrocyte- and platelets (PLTs)-rela... | The concentration of ACTH varied by age and month, with older horses showing greater seasonal fluctuations. Maximum ACTH concentration peaked in late summer and early fall, with the older horses and certain breeds showing higher concentrations. Insulin concentrations were highest in August and lowest in December, and c... | Primary clinical findings were weight loss (36/46, 78%), increased respiratory effort (33/46, 72%), tachypnea (32/46, 70%), and fever (18/46, 39%). Macrophage atypia was seen in more EMPF than asthmatic horse BALF (67% vs. 8%; P = .02). Equine herpesvirus 5 (EHV-5) was detected in 24 of 30 (80%) and hyperfibrinogenemia... | Mean maximum plasma APAP concentration was 13.97 ± 2.74 μg/mL within 0.6 ± 0.3 hour after administration. At 4 and 6 hours after treatment, both APAP (P = <.001, P = .03, respectively) and FLU (P = .0045 and P < .001, respectively) had a significantly greater decrease in rectal temperature compared to placebo. FLU caus... | The results obtained, including the finding of parasite stages during the coprological examination, confirmed the role of fasciolosis. The independent sample t-test indicated highly significantly altered values of all biochemical liver indicators in the infected animals. All animals were treated with two doses of rafox... | 42221961 | Frontiers in veterinary science | [
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0.4555560052394867,
0.470285028219223,
0.4635242521762848,
0.4804595708847046,
0.458152174949646
] |
Title: Biological variation of baseline serum cortisol concentration in healthy dogs, part 2: clinical applications. Background: Biological variation tools can be used to quantify uncertainty inherent in laboratory measurements and assist veterinarians in clinical decision making. | Expanded measurement uncertainty and bidirectional dispersion with 95% probability for baseline cortisol are 13.7 and 64.9% respectively, and these values can be used to establish a "grey-zone" around a population-based reference interval limit to guide clinical investigations. Index of individuality is intermediate (1... | A prospective observational study on 15 client-owned mixed-breed adult dogs was performed using a system equipped with contrast-tuned imaging technology. Qualitative and quantitative assessments of the spleen enhancement pattern were carried out. Three square ROIs (0.05 cm<sup>2</sup>) were manually drawn in a row and ... | The RIs for free metanephrines in plasma, urine and saliva are reported. Dogs with PCC had significantly higher pNMN than dogs with HC (P < .001) and NAI (P = .002). The PCC dogs had significantly higher pMN than HC dogs (P < .001), but not higher than NAI dogs (P = .29). Using the upper reference limit, pNMN (>3.56 nm... | Inter-rater κ statistics in the first pilot were poor, leading to clarifications and minor alterations to the CDI. Inter- and intrarater agreement for the second pilot indicated high diagnostic reliability. The CDI was validated as a tool for documenting multimorbidity in dogs. The CDI will enable veterinarians to accu... | HAC and non-adrenal illness were diagnosed in 115 (54%) and 62 (46%) dogs, respectively. The positive (+) LRs (95% CI) for the lack of suppression, partial suppression, escape, and an inverse pattern to diagnose HAC were infinite, 8.09 (2-32.72), 3.23 (0.75-14), and 0.2 (0.06-0.73), respectively. The study confirms tha... | Twelve dogs were MLM positive for HA and had further cortisol testing. Five had HA confirmed (true positive), 4 of which were treated for mineralocorticoid and glucocorticoid deficiency, and 1 was treated for glucocorticoid deficiency alone. Three MLM positive dogs had baseline cortisol ≤2 μg/dL but were euthanized or ... | 42221958 | Frontiers in veterinary science | [
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0.49977824091911316,
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0.5079964995384216,
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] |
Title: Aspartic acid-facilitated remineralization: a bio-inspired alternative to fluoride for enamel repair. Background: Dental enamel is constantly challenged by acidic conditions that disrupt the balance between demineralization and remineralization. Despite proven efficacy, current remineralization strategies face l... | While 0.5% aspartic acid alone caused enamel demineralization (mean %SMHR = -37.32 ± 24.64), its combinations with calcium sources outperformed fluoride: 0.5% Asp + 1% tricalcium phosphate system demonstrated a mean %SMHR of 42.03 ± 19.45 - significantly higher than fluoride (14.12% ± 13.40%; p = 0.0181), a system of 0... | It was observed that the ΔE of the HAP-peptide suspension after pre-treatment with NaOCl was significantly stronger than the control group. In contrast, the overall color changes of separate applications of HAP, peptide, and NaOCl did not differ notably from the control group. SEM observations confirmed that pre-treatm... | The factor under study significantly influenced ΔE00 (p=0.0001), ΔL (p=0.0024), Δb (p=0.0015), and ΔRa (p<0.001), but not Δa (p=0.1592). Both fluoride-enhanced remineralization and resin infiltration were able to mask WSL, regardless of subsequent bleaching. However, when bleaching was performed, ΔE00 median values did... | For the enamel and considering the erosive-abrasive cycle, significant differences were found between the groups tested, the bleaching, and the abrasiveness of the dentifrice tested; however, the final microhardness values were significantly lower than the initial ones. For dentin, differences were found between the er... | The FHA + B presented the lowest <i>ΔE</i>, significantly lower than other groups, except B/FHA. The <i>ΔE</i> in B/FHA was significantly lower than B/NaF. The bleaching significantly reduced the enamel hardness in three depths. The highest microhardness values were reported for B/NaF and NaF + B, which have no noticea... | The recombinant amelogenin peptide group significantly outperformed the non-phosphorylated amelogenin peptide group in terms of mineral acquisition and mineralization depth (P<0.05). The recombinant Amelogenin's solitary phosphate group at the N-terminus helps recombinant Amelogenin to encourage the remineralization pr... | 42220910 | Frontiers in bioengineering and biotechnology | [
0.8805429935455322,
0.525683581829071,
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0.527546763420105,
0.6037946343421936,
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] |
Title: Intraoperative magnesium sulphate as an analgesic adjunct in a multimodal, opioid-sparing protocol for canine ovariohysterectomy: a prospective, randomized, controlled, double-blind study. Background: Magnesium acts as a non-competitive NMDA receptor antagonist and may attenuate central sensitization. Evidence r... | All dogs completed the study (<i>n</i> = 28). Mean CMPS-SF scores at 1 h post-extubation were significantly lower in the Magnesium group compared with the Control group (3.9 ± 1.5 vs. 5.8 ± 1.9; <i>p</i> = 0.012). Pain scores varied over time (<i>F</i> = 72.368, <i>p</i> < 0.01), with a significant time x treatment int... | The dose determination study showed the systemic administration of ePB-MSCs in a canine OA model resulted in an analgesic, anti-inflammatory, and joint tissue protective effect associated with improved clinical signs and improved cartilage structure, as well as a good safety profile. Furthermore, a clear dose effect wa... | A total of fifty-eight dogs with OA chronic pain entered the uncontrolled study. Pain on HCPI was considered severe at baseline (range 18-39). Based on owner's assessment, 90% of dogs who responded to meloxicam at the full-dose regimen could reduce meloxicam up to 25% of the original dose without experiencing pain wors... | Significant differences relative to baseline values were detected following both treatments. Compared to baseline, dogs had significantly higher cortisol and 17α-OHP at 3-hours, and significantly lower TSH at 3- and 6-hours following LPS treatment. Dogs had significantly lower TSH at 6- and 24- following saline treatme... | Gastrointestinal signs developed in 10/20 (50%) dogs in the omeprazole group and in 7/17 (41%) dogs in the placebo group (P = .59). Diarrhea was common (8/20 omeprazole, 5/17 placebo), hematochezia was rare (1/20 omeprazole, 1/17 placebo); melena was not observed. Clinicopathologic evidence suggestive of bleeding was p... | No adverse effects related to tramadol or lidocaine were observed. Based on post-operative pain assessments, significant differences between groups were observed according to both pain scoring systems. In particular, in Group LT, the CMPS-F and FGS scores decreased significantly in the first six hours following castrat... | 42211339 | Frontiers in veterinary science | [
0.7144500613212585,
0.4798996150493622,
0.510332465171814,
0.4951317608356476,
0.4765926003456116,
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] |
Title: A case series of 21 adult cows with acute infectious bronchopneumonia: clinical, laboratory, and thoracic ultrasonographic findings. Background: Acute infectious bronchopneumonia is widely reported in adult cattle, yet most descriptions focus on postmortem findings. To describe signalment, clinical, hematologica... | Mean age at inclusion was 47 months (range, 24-104). Cases occurred mainly in winter (10/21) and during the early postpartum period (10/21); 17/21 were dairy cows. Typical clinical signs associated with acute respiratory disease (coughing, wheezes, and crackles) were rarely observed. Thoracic ultrasonography revealed f... | Compared with healthy cattle, HIS, IL-6, LPS, and TNF-α in subclinical laminitis group significantly increased (P < 0.05), especially HIS, LPS, TNF-α (P < 0.01); in chronic laminitis cows, COX-2, HIS, IL-6, LPS, and TNF-α increased significantly (P < 0.05), especially COX-2, HIS, TNF-α (P < 0.01). iNOS (P < 0.05), TXB2... | In both mice experiments, intramuscular immunization induced the strongest serum IgG antibody response. However, the intranasal administration of Spore-MhCP1 and Spore-MhCP2 elicited the greatest secretory IgA-specific response against leukotoxin, PlpE, and GS60 in bronchoalveolar lavage, saliva, and feces (<i>p</i> < ... | Out of 26 horses, four were diagnosed with mild (subclinical), seven with moderate, and seven with severe asthma based on clinical examination and BALF cytology. Eight horses served as controls. Cough with history of coughing was the strongest variable in phenotype differentiation. Factor analysis revealed an increasin... | Two hundred forty-eight of the 817 study calves (30.4%) were treated for BRD prior to weaning; 246 of those were from a single herd involved in two outbreaks of BRD leading to mass treatment of all calves in that group. Molecular diagnostic testing found BCV and Histophilus somni in nasal swabs taken at the time of BRD... | The obtained results revealed a highly significant increase in serum cTn I in diseased cattle with TP and TRP (P = 0.00), while buffaloes with TP showed no significant changes in serum cTn I (P = 0.111). Both diseased cattle and buffaloes showed increased serum activities of CK-MB, AST, and LDH enzyme. On the other han... | 42207578 | Journal of veterinary internal medicine | [
0.8026875853538513,
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0.5221120119094849,
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] |
Title: Evaluation of a new rapid diagnostic test, based on the chimeric protein Q5, for the diagnosis of human and canine forms of visceral leishmaniasis. Background: Visceral leishmaniasis (VL), caused by Leishmania infantum, is the most severe form of leishmaniasis, prevalent in many countries, but still with limitat... | An improved performance was seen for the human VL diagnosis (94% sensitivity), but it was reduced with canine sera (86% sensitivity). Specificity values for both the ELISA-Q5 and RDT-Q5 were generally greater than 95%, with limited (8%) or no false-positive results with human sera from individuals with cutaneous leishm... | The results showed melting curves enabling discrimination of the three Leishmania species present in Tunisia, and were further confirmed by Sanger sequencing. Application of PCR-HRM assays on reservoir host samples showed that overall among the examined samples, 45 were positive, while seven were negative, with no Leis... | Total protein and CRP levels were slightly reduced in T2 compared with T1, although the difference was not statistically significant. Antibody titers also decreased in 10 out of 18 dogs (55.5%), with two (20%) becoming seronegative, while they remained constant in eight out of 18 dogs (44.4%). Furthermore, a statistica... | Out of 112 samples collected, 71.4% of cases had anti-<i>L. infantum</i> IgG antibody titers of 1:80 and higher and therefore considered as seropositive. Furthermore, from the 70 seropositive dogs with antibody titer of 1:320 and higher, 47 (42%) had at least one of the clinical symptoms associated with VL and consider... | The assay demonstrated high sensitivity, with a limit of detection corresponding to one Leishmania cell in the reaction mix for isolates of both L. infantum and L. tarentolae. Limited cross-reaction of the L. tarentolae-targeting probe was observed on L. infantum isolates. No cross-reaction was observed with the contro... | The dogs clinically evaluated (n = 236) were classified as asymptomatic (n = 93; 39.4%), oligosymptomatic (n = 92; 39%), or polysymptomatic (n = 51; 21.6%). A total of 518 Leishmania isolates from dogs were characterised by MLEE as L. infantum (n = 456; 88%) and L. braziliensis (n = 62; 12%), which were obtained by cul... | 42207130 | Memorias do Instituto Oswaldo Cruz | [
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0.5952280759811401,
0.6240822672843933,
0.5681663751602173,
0.5730190873146057,
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] |
Title: The boron uptake via LAT1 and survival analysis after boron neutron capture therapy in canine hemangiosarcoma cell lines. Background: Canine hemangiosarcoma (HSA) is a highly aggressive malignancy with limited effective therapies. Boron neutron capture therapy (BNCT) has begun to be recognized as a potential tre... | All cell lines demonstrated BPA uptake, which was significantly reduced by BCH, confirming LAT1-mediated transport. Time-course analysis revealed cell line-dependent differences in intracellular <sup>10</sup>B accumulation. Neutron irradiation yielded greater cytotoxicity than X-rays, and BPA further enhanced this effe... | The prepared nanoparticles were uniform in size (166 nm), with good MRI performance and stability over 24 h. Compared with CBZ-Tween 80 injection, CBZ-BSA-Gd-NPs showed much lower hemolysis, similar tumor inhibition, and enhanced cellular uptake in vitro. The pharmacokinetic behavior of CBZ-BSA-Gd-NPs in rats showed th... | Our findings demonstrate the efficacy and safety of anthracycline and propranolol combination in stage 3 HSA-affected dogs. Further studies are needed to establish treatment protocols based on anthracycline and propranolol combination for dogs with advanced HSA. | Of all canine lymphomas, 55.3% were B, 31.9% were LTCD45<sup>+</sup>, and 10.6% were TCD45<sup>-</sup>. Only 2.2% were classified as nonB/nonT, and survival time differed between groups. Patients with LTCD45<sup>-</sup> lymphomas had a mean life span of 641 days after diagnosis, followed by LB (166 days) and LTCD45<sup... | In all tested canine cell lines, clonogenicity was inhibited significantly in combined treatment compared to radiation alone. All canine glial cell lines tested in this study were found to have high methylation levels of MGMT promoter. Hence, an additive effect of combined treatment in MGMT negative canine glial tumour... | Typical core-shell NP structures were observed by TEM. Particle size remained stable in fetal bovine serum and phosphate-buffered saline (PBS). Compared with DOX-SPIO, DOX-SPIO@MSCs improved cellular uptake efficiency, enhanced anti-tumor effects, and reduced the immune system response. Animal experiments demonstrated ... | 42205798 | Frontiers in veterinary science | [
0.6805246472358704,
0.45553427934646606,
0.4407275915145874,
0.4344528019428253,
0.4167841970920563,
0.4183969795703888
] |
Title: Chemically Defined Medium Enables GDNF-Driven Early Neuronal-like Phenotype of Human Dental Pulp Stem Cells. Background: Human dental pulp stem cells (hDPSCs) are a promising source of multipotent mesenchymal stem cells (MSCs) for regenerative neurology because of their inherent neurogenic potential. However, ro... | Although undifferentiated hDPSCs expressed neural progenitor markers (βIII-tubulin and Nestin), only GDNF treatment in a chemically defined medium significantly upregulated mature neuronal markers (NeuN and NF-M) and downregulated mesenchymal markers. Importantly, GDNF-treated cells exhibited key functional changes, in... | Decellularization was histologically confirmed, and DNA content was below (50 ng/mg tissue). P-ECM hydrogel was prepared with a final ECM concentration of 3.00 mg/ml while P-ECM + HA hydrogel was prepared with a final ECM concentration of 1.5 mg/ml. Total protein content in P-ECM hydrogel was found to be (439.0 ± 123.4... | MSC migration showed a dose-response relationship with SDF-1, with an optimal dosage for chemotaxis between 10 and 100 ng/ml. After scaffold implantation, the SDF-1-treated group demonstrated complete filling of the cartilage defect with mature cartilage tissue, exhibiting strong proteoglycan content, smooth borders, a... | Crossed line engravings of the matrix allowed for a most regular and ubiquitous distribution of cells and chemical as well as enzymatic matrix treatment was performed to increase cell adhesion. The biomechanical characteristics of this novel scaffold that we term CartiScaff were found to be superior to those of commerc... | We were able to generate primary cultures from vitreous human samples, growing the cells on collagen-coated plates in Iscove's modified Dulbecco's medium supplemented with 10% fetal bovine serum; primary cells expressed the hyalocyte markers. Specific cytoskeletal modifications were observed upon treatment with bFGF, T... | The three fibroblast groups successfully established a multilayered fibroblast sheet. Hematoxylin and eosin staining examination showed the thickest sheet in the oral mucosa fibroblast sheet. Immunohistochemical examination revealed that the multilayered cell sheet comprised fibroblasts expressed by vimentin. All multi... | 42193962 | Cells | [
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0.3903284966945648,
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] |
Title: Insights into Canine Idiopathic Rhinitis from a Prospective Study: A Multimodal Diagnostic Perspective. Background: Idiopathic rhinitis (IR) is one of the most common causes of chronic nasal discharge in dogs. It is a diagnosis of exclusion requiring a comprehensive diagnostic work-up to rule out other different... | A total of 46 dogs were included: 13 IR, 10 malignant tumors, six benign tumors, eight other inflammatory nasal diseases, and nine controls. All IR dogs were non-brachycephalic and of various breeds. No correlation was found between sinusitis, turbinate destruction, culture-based bacteriology, or IgE positivity. A simi... | Associative IMHA was present in 73/222 (33%) dogs. Diagnoses included toxic (24/222, 11%); infectious (17/222, 8%); neoplastic (16/222, 7%) and non-infectious inflammatory (13/222, 6%) conditions. A further 102 dogs (46%) had a finding most likely incidental, with no pertinent findings in 47/222 (21%) dogs. Associative... | Included were 11 CRS cats, 7 with mycotic rhinitis, and 7 with nasal neoplasia. In 24/25 cats, cBE was positive, with similar bacterial isolates across all groups. In CRS cats, treatment response did not consistently correlate with cBE results or antimicrobial susceptibility. 5/11 CRS cats showed clinical improvement f... | Sensitivity of IgG EIA was 30/37 (81.1%; 95% confidence interval [CI], 68.5%-93.4%) in cats and 17/22 (77.3%; 95% CI, 59.8%-94.8%) in dogs. Diagnostic sensitivity of ID was 0/37 (0%; 95% CI, 0%-9.5%) in cats and 3/22 (13.6%; 95% CI, 0%-28.0%) in dogs. Immunoglobulin G EIA was positive in all animals (2 cats and 2 dogs)... | Both treatment groups showed improvement in erythema and m-CADESI scores post-treatment. However, a statistically significant reduction in m-PVAS was only observed in treatment group 2. Remarkably, patients with baseline m-CADESI scores ≤ 12 showed significantly greater improvement in m-PVAS compared to those with scor... | Excellent (ASIT alone controlled clinical signs), good (≥50% reduction of clinical signs) and poor (<50% improvement) responses were seen in 31.5%, 28.5% and 40.1% of the dogs, respectively. No significant differences in efficacy were associated with breed, sex, age at initiation of ASIT, type of allergens in ASIT, and... | 42193731 | Animals : an open access journal from MDPI | [
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] |
Title: Identification of an F13A1 frameshift variant associated with factor XIII deficiency in a Coonhound dog with severe coagulopathy. Background: Factor XIII (FXIII) deficiency is a rare autosomal recessive bleeding disorder characterized by unstable fibrin clots and severe hemorrhagic complications. In humans, path... | A functional FXIII deficiency was identified, and a private, homozygous variant (c.1234_1239delinsTCAA) was found in exon 11 of F13A1 that predicts a frameshift and premature stop codon. This report represents only the second clinical description of FXIII deficiency in dogs and the first genetic characterization of thi... | 275 dogs were included: 128 had sepsis and 147 had non-infectious systemic inflammation. The frequency of new-onset OD was not different between these groups. Only the presence of fluid-refractory hypotension was significantly associated with a diagnosis of sepsis (OR 10.51, 3.08-35.94; <i>p</i> < 0.0001). The frequenc... | Mesothelin complementary deoxyribonucleic acid (cDNA) was amplified via RT-PCR, yielding a single band of expected upon DNA electrophoresis. Sequence analyses confirmed it as a predicted canine mesothelin transcript from the genome sequence database. Comparative sequence analysis of the deduced amino acid sequence of t... | Next Generation Whole Genome sequencing was performed using DNA isolated from peripheral blood of a Maine Coon with cardiomyopathy that tested negative for the <i>MYBPC3</i> A31P variant. Through risk stratification of variants, we identified a novel, homozygous intronic variant in cardiac troponin T (<i>TNNT2</i>). <i... | Fourteen PICO questions were developed, generating 14 guidelines. The majority of the literature addressing the PICO questions in dogs is experimental studies (level of evidence 3), thus providing insufficient evidence to determine if thrombolysis improves patient-centered outcomes. In cats, literature was more limited... | Two subjects were administered a low inoculum (10<sup>4</sup> parasites) while three received a high (10<sup>8</sup> parasites). Subjects were monitored for 8 consecutive days; anti-parasite treatment with diminazene aceturate was administered on day 4. Blood was drawn prior to inoculation as well as every experimental... | 42184124 | Journal of veterinary internal medicine | [
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] |
Title: Paroxysmal atrial fibrillation-like bursts in racehorses: do they affect speed and performance? A case control study. Background: Paroxysmal atrial fibrillation (pAF) occurs sporadically in horses and has been implicated in poor performance. Diagnosis in large numbers of horses has previously relied on post-exer... | Eleven cases with pAF-like bursts and 10 controls with normal exercising ECGs were identified, among 100 ECG consultations. The pAF-like bursts occurred in all horses during peak exercise (60-68 km/h; heart rate, 206-217 beats per minute), with normal ECGs during warm-up and recovery. The duration of pAF-like bursts ra... | An ECG device was available for 55 out of 102 respondents (54%) and 41 (43%) claimed to use it in case of arrhythmia suspicion. Insufficient knowledge about ECG interpretation and immediate patient referral upon detection of an abnormal heart rhythm were the most important reasons for not having, or not using, an ECG. ... | Fifty-six horses were included in the study; 18 TGMHS, 10 non-TGMHS, 12 LAME and 16 CONTROL. Characteristics and frequency of vertical (Z axis) head movements of TGMHS horses differed significantly from other horses. TGMHS horses had peaks with greater mean and maximum positive g-force (P < 0.005) and lower mean and mi... | In Thoroughbreds, synovial fluid concentrations of metabolites 2-aminobutyrate, alanine and creatine were elevated for higher OA grades, while glutamate was reduced for both Thoroughbreds and mixed breeds. In mixed breeds, concentrations of three uncharacterised proteins, lipopolysaccharide binding protein and immunogl... | We included 89 client-owned dogs with occult and overt echocardiographic DCM. Of these, 39 dogs (43.8%) had atrial fibrillation, 29 dogs (32.6%) maintained a sinus rhythm, and 21 dogs (23.6%) showed other cardiac arrhythmias. Left atrial diameter had high accuracy (area under the curve = 0.816, 95% CI = 0.719-0.890) to... | Equine FVEPs were recorded from one randomly selected eye in 17 horses, from both eyes in eight of these horses, and also at two separate recording sessions in six horses. N1, P2, N2 and P4 wavelets were present in 100% of the recordings in all horses, while P1, N2a, P3 and P5 were only present in some recordings. Coef... | 42172118 | Journal of veterinary internal medicine | [
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0.4606034457683563,
0.45742225646972656,
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0.5238054990768433,
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] |
Title: Accuracy of Orthodontic Malocclusion Detection Using Multiple AI Models: A Comparative Study. Background: This study aimed to evaluate and compare the accuracy of multiple artificial intelligence (AI) models (ChatGPT 5.2 Pro, Gemini 3 Fast, Claude 4.5 Sonnet, and Microsoft Copilot) in detecting orthodontic maloc... | Agreement between the AI models and the orthodontist ranged from poor to moderate across all orthodontic domains, with Cohen's κ values ranging from -0.15 to 0.63. Visually prominent alignment features, including anterior crowding and diastema, demonstrated comparatively higher agreement (κ, 0.00-0.63) and discriminato... | Based on these findings, the SmartForce Aligner Activation protocol may be successful in the orthodontic management of deep bite growing patients. | Analysis of the landmarks revealed that 20-30 % of the principal components explained 80 % of the shape variation. No significant difference in centroid size was found between sexes, but significant shape differences were noted in all teeth except the 3-cusp type mandibular second premolar. Asymmetry was more in the pr... | Out of 38 respondents, 44.7% were orthodontists, 34.2% dentists, 15.8% dental students, and 5.3% dental technicians. Most respondents (44.7%) were between 35 and 44 years old, and only 1 (2.6%) respondent was 55-64 years old. Median answers for six questions were 'totally agree' (25th percentile 1, 75th percentile 2) a... | The chatbots and orthodontists showed moderate agreement regarding treatment decisions (κ = 0.411-0.524, <i>P</i> < 0.05). Gemini produced significantly more discordant responses, frequently over-recommending orthodontic eruptions (<i>P</i> = 0.002), whereas Grok and ChatGPT received significantly higher scores than Ge... | The integration of multiloop orthodontic mechanics and periodontal crown lengthening represents a predictable and comprehensive interdisciplinary strategy for managing deep bite with a gummy smile, resulting in significant improvements in occlusion, tooth proportions, and facial esthetics. | 42167739 | Healthcare informatics research | [
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] |
Title: Successful Emergent Surgical Repair of Post-Myocardial Infarction Ventricular Septal Rupture With Cardiogenic Shock. Background: Post-myocardial infarction (MI) ventricular septal rupture (VSR) is a rare mechanical complication associated with very high mortality, particularly when complicated by cardiogenic sho... | Emergent surgical repair of post-MI VSR may be lifesaving even in extreme clinical scenarios when guided by rapid diagnosis and coordinated multidisciplinary care. Early recognition and prompt multidisciplinary intervention are critical for survival in catastrophic post-MI VSR. | SB-VPAT ≥33.5 ms had a sensitivity of 94.4% and specificity of 83.6% for the detection of systolic dysfunction due to preclinical DCM stage B2 (AUC 0.954, SD 0.022). Furthermore, SB-VPAT was strongly correlated with the left ventricular systolic diameter, systolic volume index and moderately inversely correlated with E... | A total of 20 patients (17 males <i>vs.</i> 3 females), with a median age of 7.5 years [min-max, 0.3-12 years; interquartile range (IQR), 4.4-9.7 years], a median body weight of 24.0 kg (min-max, 6.0-52.3 kg; IQR, 15.6-31.0 kg), and median aortic valve annulus size before surgery of 19.0 mm (min-max, 11.0-25.0 mm; IQR,... | Successful surgical treatment to this extent was demonstrated for the first time. Due to the high perioperative mortality, the surgical treatment of patients with this constellation would be refused in most cases. In our patient, the preoperative imaging showed extreme calcification of both valves and the surrounding m... | P-MAIVF is a rare but potentially life-threatening complication of IE, for which timely diagnosis and prompt appropriate therapeutic intervention are required. In the present case, although neither obvious active IE nor history of previous IE could be identified, healed IE was considered based on the clinical course. T... | Three months after the surgery, TTF indicated mild right ventricular outflow obstruction and pulmonary valve regurgitation. Correction of the left ventricular double outlet with a handmade trileaflet-valved conduit has been shown to have excellent performance, and long-term outcomes should be followed over time. | 42165477 | JACC. Case reports | [
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] |
Title: Intra-articular injections of liposomal adenosine improve clinical outcomes and slow radiologic progression in a preclinical canine model of osteoarthritis. Background: To test new, more stable and long-lasting formulations of liposomal adenosine in the treatment of OA in a preclinical canine model. | Symptomatic OA developed by 2 months with increased pain, loss of function and diminished CROM. Saline treatment did not improve knee pain, CROM or loss of function at any time point but intraarticular injection of RgnA09M and RgnA09N markedly improved pain, CROM and function at all timepoints. Injections of RgnA09M an... | There was no significant difference in the number of nucleated cells in the SVF from the two sites. The CFU/g of fat from falciform was 378.9 ± 293 g and from flank was 486.8 ± 517 g, and this was also insignificant. Neither age nor weight of the patient had an impact on the SVF or CFU/g. No surgical complications were... | Repetitive intra-articular injections with human IL4-10 FP led to antibody formation, that blocked its functional activity. Therefore, a canine IL4-10 FP was developed, which completely inhibited LPS-induced TNFα production by canine blood cells, and increased proteoglycan synthesis of canine cartilage in vitro (p = 0.... | All post-treatment urinalysis, CBC and clinical chemistry results were within normal ranges. Joint fluid analysis showed a significant (P=0.0411) reduction in the percentage of monocytes at 180 days, consistent with the tin-117m colloid mode of action of apoptosis of pro-inflammatory macrophages at the injection site. ... | Tumor types included osteosarcoma or suspected osteosarcoma (5), plasma cell tumor (2), and grade 3 fibrosarcoma (1). Radiation protocols were hypofractionated (palliative intent) in 5 dogs and fractionated (definitive intent) in 3 dogs. Five dogs experienced complications following both RT and surgery, including grade... | The outcomes obtained at the time of the surgery (T0) and for the following 12 months (T12) showed an improvement in the functional parameters (BHSII from a median of 74.3 [range, 58.1-82.4] at T0 to 95.6 [range, 94.1-99.3] at T12]). The OA did not change in 3 dogs and increased by only 1 point in 2 dogs. In this preli... | 42164095 | Osteoarthritis and cartilage open | [
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0.48432570695877075
] |
Title: Effects of phthalimidoperoxycaproic acid (PAP+) associated or not with LED irradiation as a bleaching agent: an in vitro study. Background: To evaluate the efficacy and safety of phthalimidoperoxycaproic acid (PAP+) as a bleaching agent, combined or not with blue or violet LEDs. | VIO delivered approximately 10% of MMO irradiance. Irradiation reduced gel pH, but values remained above 5.8. PAP did not differ from controls, regardless of LED use (p > 0.05), whereas HP10 showed greater bleaching efficacy, especially when combined with MMO (p < 0.05). No morphological enamel damage was observed, and... | Lesion depth did not significantly affect early-stage discoloration (<i>p</i> > 0.05). However, a significant interaction was found between lesion depth and bleaching type at later stages (<i>p</i> < 0.001). In-office bleaching significantly improved Δ<i>E</i> <sub>00</sub> compared to at-home bleaching but only in s... | Whitening toothpastes containing optical colorants were effective for whitening the enamel, as whiter teeth were observed following treatment (higher means of Δ<i>WI</i> <sub><i>D</i></sub> ). In addition, when the parameters Δ<i>E</i> <sub>ab</sub> and Δ<i>E</i> <sub>00</sub> were evaluated, these toothpastes were gra... | All HP-treated groups showed significantly greater color change compared to the control group. Surface roughness increased after bleaching; however, groups treated with desensitizers, fluoride, and/or propolis showed lower Ra values at T<sub>2</sub> compared to baseline. For microhardness, only the HP35%+KF+P group mai... | Significant differences were observed when the bleached groups were compared to the NC group for ∆E*ab, ∆E00, and ∆WID at time T3 (<i>p</i>= <0.0001). However, the bleached groups presented no significant differences regarding studied times (<i>p</i>> 0.05). KHN did not differ significantly among the six groups (<i>p</... | In vitro (bovine teeth), chromatic changes were not influenced by bleaching gel volume, showing similar values in all groups and sessions, except for the control group (p<0.05). The V120 group had the highest HP diffusion values (p<0.05). In vivo (pulp tissue), the V4 and V8 groups showed the highest inflammatory infil... | 42159783 | Lasers in medical science | [
0.6643162369728088,
0.49631547927856445,
0.4829004406929016,
0.47887998819351196,
0.4863518476486206,
0.4567521810531616
] |
Title: Short-Term Daily Oral Administration of Cannabidiol Does Not Impact Rebound Tonometry Intraocular Pressure or Schirmer Tear Test Values in Healthy Adult Horses. Background: To assess the effect of orally administered cannabidiol (CBD) on TonoVet measured intraocular pressure (IOP) and Schirmer tear test I (STT) ... | Overall, there were no clinically relevant differences in IOP with CBD administration. Irrespective of treatment, IOPs were significantly higher in the second treatment period (p = 0.009). There were no differences in STT with CBD administration. Oral CBD administration in healthy horses does not impact rebound tonomet... | Thirty-three horses that received LAIO and 12 that received ORLO were identified. Nine horses in the LAIO had received other treatments previously. The groups were comparable in signalment and EGGD lesion severity. Long-acting injectable omeprazole was found to be non-inferior to ORLO. LAIO was associated with better h... | Twenty-four horses were included in the study. Horses were referred for a variety of upper airway abnormalities including epiglottic entrapment, dysphagia and respiratory stridor. Of the horses admitted for epiglottic entrapment (18), a more accurate diagnosis of epiglottitis was made based on admission endoscopy. Hors... | 32 eyes (29 horses) were included. Based on clinical evaluation, uveitis was classified as anterior (91%) or panuveitis (9%). 10 eyes were treated with IVGI twice. A positive outcome was observed in 13/32 eyes (41%). Inflammation in 9/32 eyes was controlled after the first, and in 4/10 eyes after the second IVGI treatm... | At the 9 mg/kg/day dose, the decrease in total seizure frequency was significant compared with placebo. A 24.1% decrease in seizure days occurred in dogs receiving CBD and a 5.8% increase occurred in dogs receiving placebo (P ≤ .05). No significant difference was found in the number of responders (≥50% decrease in tota... | Short-term complications were few; at 24 h minor swelling occurred in 29 and 33% of horses sutured with KBS and SS respectively and cutaneous dehiscence during recovery occurred in two horses of each group. Post-discharge follow-up revealed that three horses needed veterinary attention for treatment of complications (s... | 42141801 | Veterinary ophthalmology | [
0.6054991483688354,
0.4782096743583679,
0.5008514523506165,
0.4737163484096527,
0.4790009558200836,
0.4986018240451813
] |
Title: Descriptive assessment of cardiac changes in cats with feline infectious peritonitis. Background: Myocarditis and myocardial injury associated with feline infectious peritonitis (FIP) recently are being recognized. Prospectively document the frequency of cardiac changes in cats with FIP using echocardiography an... | All echocardiographic measurements were normalized to patient body weight. The left ventricular posterior wall from right parasternal long axis and short axis was thickened in 55% (11/20) and 25% (5/20) of cats, respectively. Pleural effusion was present in 40% (8/20) of cats and pericardial effusion in 25% (5/20) of c... | Forty-one cases met the inclusion criteria. Of 2002 cats that were tested, 41 cats (2%) met the inclusion criteria. One cat had a negative point of care antigen test result and positive bone marrow IFA result. The mean age at diagnosis was 9 years. The main reasons for presentation were abnormal complete blood cell cou... | The study findings indicate that FIP was a disease affecting cats aged 1-2 years and was highly prevalent among male cats. Clinical manifestations of FIP affected the digestive (60%), hematological (53.3%), respiratory (33.3%), neurological (6.7%), and ocular (4.4%) systems. Blood profiles revealed mild anemia, lymphop... | SNAP fPL was normal in 133/150 cats (specificity 89%) without obvious clinical pancreatitis. SNAP fPL was normal in 74/82 healthy cats (specificity 90%) and in 59/68 cats that were sick but without typical signs of pancreatitis (specificity 87%). The agreement between SNAP fPL and Spec fPL was substantial (k = 0.64) in... | Medical records of 21 client-owned cats with CHF (median age = 10.6 years [interquartile range (IQR) = 6.5-11.2]) receiving torasemide were reviewed. Data collected included torasemide dosages, other concurrent medications, physical examination features, echocardiographic data, and potential adverse effects during foll... | The study population consisted of 365 dogs and 515 cats to give a total of 880 patients hospitalised at the IDIU from October 2013 to December 2018. Among the 96 referred dogs, parvovirosis (37.7%) and leptospirosis (31.1%) were the most frequent IDs. Feline upper respiratory tract infection (38.2%) and feline leukaemi... | 42139320 | Journal of veterinary internal medicine | [
0.7293243408203125,
0.5787086486816406,
0.5762820243835449,
0.575609564781189,
0.5677974224090576,
0.6076012849807739
] |
Title: Bacteria and associated antibiotic resistance in air filter-derived biological material from utility vehicles at mechanical-biological treatment plants. Background: The study objective was to assess occupational exposure to bacteria and antimicrobial resistance genes (ARGs) present on air filters of utility vehi... | Totally, 34 bacterial taxa were detected in relative abundance ≥0.5%. The genera most frequently present at the highest relative abundances: <i>Saccharomonospora, Thermobifida, Nocardiopsis, Pectobacterium, Aerococcus, Thermoactinomyces, Novibacillus</i> and <i>Streptomyces</i>. Across all bacteria isolated from the an... | A total of 73 isolates were identified from 30 donkeys, of which 92% of the isolates were Gram-negative bacteria. Mixed cultures were found in 90% of the donkeys. The most common isolates were <i>Escherichia</i><i>coli</i> (31.5%) and <i>Acinetobacter</i> spp. (21.9%). Susceptibility testing revealed that amikacin (98%... | Our findings revealed that 73% (146/200) of the examined milk samples collected from dairy cows with clinical mastitis were infected with Streptococci species. Of these, 9.59% (14/146) were identified as S. agalactiae and categorized as MDR. S. agalactiae isolates expressed four virulence genes (Hyl, cylE, scpB, and lm... | Hospitalisation without antimicrobial treatment did not significantly affect microbiota composition. Oral TMS treatment reduced alpha-diversity significantly. Kiritimatiellaeota, Fibrobacteres and Verrucomicrobia significantly decreased in relative abundance, whereas Firmicutes increased. The faecal microbiota composit... | Ninety eight percent (98%) of farmers gave antibiotics as prophylactic treatment to day old chicks. There were 47 different products used in the two states within the study period. We observed that five classes of antibiotics (Tetracyclines, Penicillins, Aminoglycosides, Polypeptides and Fluoroquinolone) were used in t... | The study showed rational use of antimicrobials, consisting of occasional use for curative treatment by veterinary prescription. Tetracycline was the most commonly used antimicrobial, but its use was not correlated to E. coli resistance. Extended-spectrum β-lactamase (ESBL) E. coli isolates were detected in 7.3% of pig... | 42138097 | International journal of occupational medicine and environmental health | [
0.563582718372345,
0.38406646251678467,
0.3713774085044861,
0.3841181695461273,
0.3895297348499298,
0.3832094073295593
] |
Title: Optimization and comparison of different methods for assessing cell viability in intervertebral disc organ cultures. Background: Whole-organ intervertebral disc (IVD) culture is widely used to study IVD degeneration and evaluate regenerative therapies. Spatial visualization of resident cell viability is essentia... | Selection of suitable controls was critical for reliable viability assessment. Calcein AM/EthD-1 provided a straightforward approach but required protocol modifications, including Collagenase P pre-treatment, to ensure adequate tissue penetration. This method also requires immediate processing and imaging after harvest... | PRP treatment resulted in the formation of a fiber network connecting the bioengineered cartilage and native osteochondral plug. Cells from both the bioengineered cartilage and the native osteochondral tissue migrated onto the PRP fibers and formed a tissue bridge after 2 weeks of culture. Migratory cells on the tissue... | Several VGICs were identified at the protein level, one of which, Cav2.2, appears to be upregulated with the onset of human IVD degeneration. Inhibiting L-type VGCCs with Nf supplementation led to an altered cell calcium influx in response to osmotic loading as well as downregulation of col 1a, aggrecan and ADAMTS-4 du... | Canine AD-MSCs promoted neural functional recovery, reduced neuronal apoptosis, and inhibited the activation of microglia and astrocytes in TBI rats. According to the results in vivo, we further investigated the regulatory mechanism of AD-MSCs on activated microglia by co-culture in vitro. Finally, we found that canine... | Statistical analysis confirmed the significant effect of using multiple doses, and regression analysis revealed a significant influence of age and weight on treatment outcome. Additionally, a logistic regression predicting improvement over time was extrapolated from these results to help clinicians and owners make bett... | MSC homing enhanced the fraction of Tie2-positive IVD cells in bovine and human IVD samples. Furthermore, a proliferative response and lower fraction of dead cells were observed after MSC homing in both bovine and human IVD tissues. Our findings indicate that MSC homing enhances the survival and regenerative capability... | 42137623 | Frontiers in bioengineering and biotechnology | [
0.5880906581878662,
0.38894596695899963,
0.37465012073516846,
0.3747788667678833,
0.3854408264160156,
0.4485127627849579
] |
Title: Epidemiology and clinical management of 1072 dogs with diabetes mellitus in a UK diabetes register. Background: The UK Canine Diabetes Register and Archive (UKCDRA), established in 1999, is a valuable resource of clinical data and blood samples from diabetic dogs. This study aimed to provide updated information ... | Ninety-nine breeds were represented in the study, with 25 breeds having 5 or more diabetic cases. Samoyeds and Tibetan terriers demonstrated the highest odds of DM in both of the adult-onset DM groups. Age of adult-onset DM onset co-varied with breed, with the Standard Doberman Pinscher and Rottweiler demonstrating you... | Median (range) PU/PD scores of combined visits 5-8 (0, 0-1) were significantly lower than median scores of combined visits 1-4 (1, 0-1, p = 0.03) and at enrolment (1, 0-1, p = 0.045). Median (range) SFC of combined visits 5-8 (512 mmol/L, 401-974 mmol/L) was significantly lower than SFC of combined visits 1-4 (578 mmol... | This study found the presence of anti-IA2 antibodies in 58% of the sample (18/31 patients with DM); however, the presence of anti-GAD65 was not detected, and anti-ZnT8 was found in 3 (9.6%) patients with DM. This study showed a higher positive frequency of anti-IA2 antibodies in a sample of canine with DM, indicating t... | There was a higher prevalence of signs of chronic GI disease in the dogs with a previous episode of AHD compared to control dogs (AHD 28%; controls 13%; P = .03; odds ratio = 2.57; confidence interval [CI] 95% 1.12-6.31) over a similar observation time (median 4 years; range, 1-12 years). Severe intestinal mucosal dama... | Associative IMHA was present in 73/222 (33%) dogs. Diagnoses included toxic (24/222, 11%); infectious (17/222, 8%); neoplastic (16/222, 7%) and non-infectious inflammatory (13/222, 6%) conditions. A further 102 dogs (46%) had a finding most likely incidental, with no pertinent findings in 47/222 (21%) dogs. Associative... | 76 Labrador Retriever puppies were recruited via Dogslife, a UK-based online cohort study. Faecal samples were collected at three to four, seven, and 12 months of age and analysed using 16 S rRNA gene sequencing alongside questionnaire data. Alpha and beta diversity were assessed using linear mixed effects models and p... | 42135839 | Companion animal health and genetics | [
0.8173210024833679,
0.5416606068611145,
0.5452339053153992,
0.5298783779144287,
0.5470967888832092,
0.5195461511611938
] |
Title: Differential gene expression analysis in French bulldog high grade oligodendroglioma: breed-associated differences in tumor and tumor microenvironment gene expression. Background: Several canine breeds, including boxers, Boston terriers, and French bulldogs, belong to the same phylogenetic clade and have a highe... | There were 31 DEGs in HGO samples from French bulldogs compared to boxers and Boston terriers. Gene set enrichment analysis revealed activated enrichment of 15 cell cycle progression, oncogene, and immune pathways, including E2F targets, mTOR signaling, IL2-STAT 5 signaling, and allograft rejection. These data confirm ... | This study found three distinct TME subtypes of canine osteosarcoma based on cell type composition of bulk tumor samples: immune enriched, immune enriched dense extracellular matrix-like, and immune desert. These three TME-based subtypes of canine osteosarcomas were conserved in humans and could predict progression-fre... | The genome-wide association study gave an indicative signal on canine chromosome 21. Although the signal was not of genome-wide significance due to the small number of cases, the <i>SBF2</i> (also known as <i>MTMR13)</i> gene within the region of shared case homozygosity was a strong positional candidate, as 22 genetic... | RNA-ISH and IHC showed moderate to strong expression for IBA-1 and CD204 in the neoplastic cells in both the canine DH82 cell line and the archived canine HS samples. RNA-ISH and IHC showed scattered positive staining in the control tumours samples, consistent with macrophagic infiltration. RNA-ISH for CD204 and IBA-1 ... | The expression of canine Nectin-4 (high Nectin-4) was found in 25 of 34 cases (73%), and Nectin-4 expression levels did not show any significant associations with gender, body weight, and tumour stage. However, there was a significant positive correlation between Nectin-4 expression and tumour volume (r = 0.623, p < 0.... | Distinct cytological features of canine IMC included scarce cellular cohesiveness, ballooning aspect of neoplastic cells, frequent multinucleation, irregularly dispersed and ropy chromatin pattern, and squamous metaplasia in some individualised cells or those in small groups. Our results indicate that cytological exami... | 42135822 | Companion animal health and genetics | [
0.752504825592041,
0.5167635083198547,
0.46885788440704346,
0.5145503878593445,
0.4633386731147766,
0.46363791823387146
] |
Title: Prevalence of tracheal collapse syndrome, congenital portosystemic shunts, or both in Yorkshire Terriers at one veterinary hospital. Background: The prevalence of tracheal collapse syndrome (CTCS) and congenital portosystemic shunts (CPSS) in Yorkshire Terriers is poorly characterized. It is conceivable that CPS... | A total of 11 061 Yorkshire Terriers were identified, with 7263 having data for age at last visit available. The observed prevalence of CPSS was 0.8% (93 dogs), severe CTCS was 6.7% (739 dogs), and both conditions were 0.05% (6 dogs). The median age at diagnosis was 2.7 years (interquartile range [IQR], 1.0-5.7) for CP... | Twenty-eight questions pertaining to temperature management, respiratory and metabolic support, and CPR were addressed. Of the 59 treatment recommendations formulated, 21 concerned medications, 20 addressed respiratory measures, 20 provided guidance on CPR, and 3 related to temperature management. Taken together, the r... | No statistical difference could be detected between both prevalence rates (<i>p</i> = 0.475). It was found a significant predilection of the condition to the female sex (<i>p</i> = 0.034). Further, the two radiographic methods employed here were highly concordant each other (kappa = 0.92). Through the EK/L method a PMC... | This study included 540 cats with 615 respiratory diagnoses. The American Shorthair breed was predisposed to bronchopneumonia (BP; OR: 5.0) and pulmonary tumour (PT; OR: 3.6), while the Russian Blue breed exhibited a predisposition to inflammatory lower airway diseases (OR: 3.4), BP (OR: 6.1) and interstitial lung dise... | Prognosis in animals with ARDS is influenced by the severity of respiratory compromise, the underlying cause, and the timelines of appropriate interventions. The updated definitions will aid clinicians in early and timely recognition of ARDS, although further studies are needed to assess its impact on clinical outcomes... | Only 11.6% of the maxillary canines needed treatment, including interceptive procedures. The treated canines significantly more often had overlapping (p < 0.001), larger inclination (p = 0.001) and incomplete lateral incisors (p = 0.002) than did the naturally erupted canines. The children treated significantly more of... | 42132355 | Journal of veterinary internal medicine | [
0.6181133985519409,
0.44328629970550537,
0.43368151783943176,
0.4619867503643036,
0.4391404092311859,
0.43944650888442993
] |
Title: Synergistic HA-tooth graft composite promotes rapid alveolar bone healing via IL-6 suppression and OCN enhancement. Background: Periodontitis leads to continuous alveolar bone destruction driven by persistent inflammation, particularly elevated interleukin-6 (IL-6). Bone healing after tooth extraction under peri... | The HA + BTG group showed a significant reduction in IL-6 expression and a significant increase in OCN expression and woven bone area compared with the control (p < 0.05). An inverse trend between IL-6 and OCN reflected the transition from inflammation to osteogenesis. HA + BTG enhances alveolar bone regeneration by su... | The results showed that the anti-inflammatory property of mustard seed extract is comparable to diclofenac sodium whereas the maximum zone of inhibition was seen against <i>C. albicans</i>. This study discovered that mustard seed extract has potent antimicrobial and anti-inflammatory activity against a variety of oral ... | Decellularization was histologically confirmed, and DNA content was below (50 ng/mg tissue). P-ECM hydrogel was prepared with a final ECM concentration of 3.00 mg/ml while P-ECM + HA hydrogel was prepared with a final ECM concentration of 1.5 mg/ml. Total protein content in P-ECM hydrogel was found to be (439.0 ± 123.4... | Control group cases (n = 9) revealed nice embedding of graft particles into newly formed bone, which were predominantly present in the central and apical third of the biopsy samples. The coronally located DBBM was more often encapsulated in the connective tissue. Test samples (n = 10), both at the tension and pressure ... | The bioengineered implant facilitated complete mucosal integration and osteoconduction at the 10-month follow-up, demonstrating promise for complex ONF repair. However, the single-case design limits the generalizability. | The bone level on radiographs significantly improved (median -0.15 mm, IQR -0.31 to 0.10) only in the BDNF/HMW-HA group, while changes in PPD and AL were similar to those in other groups. The BOP positivity rate decreased in the debridement and BDNF/HMW-HA groups. Unlike images of the other groups, histological images ... | 42125205 | Journal of oral biology and craniofacial research | [
0.817352294921875,
0.4925737977027893,
0.49348002672195435,
0.480985552072525,
0.5319899320602417,
0.5663617253303528
] |
Title: Eprinomectin Inhibits <i>Leishmania</i> by Inducing Mitochondrial Dysfunction and Cell Cycle Arrest. Background: Leishmaniasis remains a significant global health challenge, with current therapies often hampered by toxicity, resistance, and high cost. In this study, we investigated the antileishmanial potential ... | Eprinomectin exhibited selective activity against <i>Leishmania</i>. SEM imaging suggested division-related morphological abnormalities, consistent with direct antiproliferative effects. Treatment significantly reduced parasite load and antigen levels in vivo. Transcriptomic analysis suggested mitochondrial dysfunction... | The assay demonstrated high sensitivity, with a limit of detection corresponding to one Leishmania cell in the reaction mix for isolates of both L. infantum and L. tarentolae. Limited cross-reaction of the L. tarentolae-targeting probe was observed on L. infantum isolates. No cross-reaction was observed with the contro... | As per consensus standard criteria, 52 of the lesions were qualified to evaluate MCM versus TCM. Forty-eight lesion samples were positive by MCM, 36 by TCM, and 37 by smear microscopy. The representative DNA from parasite culture isolates revealed the causative <i>Leishmania</i> parasite was <i>L. aethiopica</i> by ITS... | Following treatment with 50 nM of SHBG, analyses were conducted to assess cell viability, mitochondrial metabolism and dynamics, as well as the expression of inflammatory and anti-inflammatory markers. Results showed that SHBG significantly enhanced mitochondrial flexibility, as indicated by the upregulation of MFN-1, ... | Considering the cut-off point of 0.23, the test showed a sensitivity of 98% (95%CI=89.50%-99.90%) and a specificity of 95.31% (95%CI=87.10%-98.72%). Kappa analysis indicated very good agreement (kappa=0.831) between ELISA and DAT (<i>P</i><0.05). ELISA using the recombinant protein P1P2P3 has great potential for the di... | Histopathological analyses showed a granulomatous inflammation within the dermis, with multi-nucleated giant cells, macrophages, lymphocytes and few neutrophils and eosinophils. We detected the parasite by immunohistochemistry, using a rabbit polyclonal antibody raised against Leishmania spp. However, we could not iden... | 42124919 | Transboundary and emerging diseases | [
0.8451436758041382,
0.4069293141365051,
0.4178081452846527,
0.4033450186252594,
0.42665478587150574,
0.4473493695259094
] |
Title: In Vitro Antidiabetic Activity and Mechanism of Action of Methanolic Extract of Opuntia stricta Cladodes. Background: Type 2 diabetes mellitus (T2DM) is characterized by insulin resistance and β-cell dysfunction, leading to chronic hyperglycemia. Although Opuntia species have demonstrated antidiabetic potential,... | The OSC extract showed good tolerability, with cell viability > 80% across all cell lines. In C3A hepatocytes, glucose utilization increased significantly at 6.25-100 μg/mL (p < 0.001), with the highest effect at 100 μg/mL (90.1% ± 0.3%) compared to untreated (86.3% ± 0.4%). Glucose uptake was also significantly enhanc... | GLU and FRU concentrations in the RYGB group were significantly lower than in diabetic controls (<i>p</i> < 0.05), remaining comparable to the insulin-treated group (<i>p</i> > 0.05). Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were significantly reduced post-RYGB (<i>p</i> < 0.05), c... | These agents with protective effects against oxidative stress in ECs mainly include phenylpropanoids, flavonoids, terpenoids, and alkaloids. Most of these agents alleviate cell apoptosis in ECs due to oxidative stress, and the mechanisms are related to Nrf2/HO-1 signaling activation. However, despite continued progress... | A total of 1425 metabolites were detected in the negative ion mode and 1298 metabolites were detected in the positive ion mode. After drug treatment for 24 h, 48 h, and 72 h, there were 56, 162, and 243 differential metabolites in negative ion mode, and 35, 121, and 177 differential metabolites in positive ion mode, re... | Administration of dexamethasone for 14 days resulted in significantly altered insulin and glucose dynamics (SI, DI, basal [glucose], and [insulin]) and produced clinical signs of laminitis in 5 out of 33 (15%) of horses included in the study. Combination therapy with RES, MET, and ASP did not significantly improve insu... | The OXIME blocked the increase of plasma markers of hepatic function (AST and ALP) and the enzymatic inhibition of catalase and glutathione reductase in the liver of malathion-treated rats. Moreover, the hepatic cholinesterases inhibition induced by malathion acute exposure was suppressed by OXIME treatment. As assesse... | 42113019 | BioMed research international | [
0.45178791880607605,
0.36298099160194397,
0.35811367630958557,
0.3413008749485016,
0.39021381735801697,
0.35048893094062805
] |
Title: A bibliometric analysis of the literature on <i>Mycoplasma</i> and <i>Ureaplasma</i> infections. Background: <i>Mycoplasma</i> and <i>Ureaplasma</i> species are understudied opportunistic pathogens that infect humans, animals and plants. These infections are often asymptomatic, which, together with fastidious gr... | China and the United States produced a high number of publications and citations. South Africa, the first most-cited African country, contributed 685 publications, ranking 24th globally with 2031 citations. <i>Veterinary Microbiology</i> was the highest performing journal with 448 papers and 10 036 citations. The most ... | Although there have been few reports of this clinical presentation in veterinary medicine, two in cats and one in a female schnauzer, this is the first reported case of cystitis glandularis associated with urinary tract infection due to Escherichia coli. The importance of bacteriological and histopathological studies i... | Rapid-growing mycobacterial cases included Mycobacterium smegmatis (9), Mycobacterium fortuitum (4), Mycobacterium abscessus (1), and Mycobacterium thermoresistibile (1). Mycobacterium avium infections were more likely than RGM infections to be disseminated (3/4 vs 0/15; P = .004). Disease of the skin/subcutis (15/15 v... | IMHA/ITP is associated with remodeling of fecal microbiota, marked by decreased relative abundance of the spirochete Treponema spp., increased relative abundance of the pathobionts Clostridium septicum and Escherichia coli, and increased overall microbial diversity. Logistic regression analysis demonstrated that Trepon... | Fifty-seven ears (30 dogs) completed the study. PS, OTIS-3, and CS were significantly decreased at D7 and D14 (-45%, -43%, -60% and -77%, -66%, -76%, respectively; p < 0.0001 Wilcoxon test). Fungal culture was positive (Malassezia spp.) in only 34 ears at D0 and was negative in all ears at D14. Mycobiota composition wa... | All participants greater than 41 years old reported correctly the presence and absence of parasites on slides. Only 3/8 of microscopists from routine diagnostic laboratories reported correctly the presence of the parasite. Our study confirmed errors in reading slides. Therefore, training of microscopists besides a nati... | 42111230 | Southern African journal of infectious diseases | [
0.7042034864425659,
0.42506328225135803,
0.4625292122364044,
0.39646434783935547,
0.39981478452682495,
0.39910614490509033
] |
Title: Efficacy of non-steroidal anti-inflammatory drug (NSAID) treatment for bovine respiratory disease: a systematic review and meta-analysis for the European Network for Optimization of Antimicrobial Therapy guidelines. Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used as ancillary therapy f... | Seventeen RCTs (22 comparisons; 4,909 animals) compared NSAID+antimicrobial versus antimicrobial alone. Adding an NSAID did not reduce re-treatment (RR 0.94, 95% CI 0.84-1.05; I <sup>2</sup> = 0%; moderate certainty). Subgroup (same vs different antimicrobial) and sensitivity analyses (handling of multi-arm trials; fol... | The total clinical score significantly improved over the entire study period (p<0.001). Significant improvement was detected for the frequency of coughing (p = 0.009), respiratory distress (p = 0.001), lung auscultation findings (p = 0.002), and general condition and appetite (p = 0.045). The BWBP parameter Penh, an in... | The highest maximum plasma concentration (Cmax)/minimum inhibitory concentration (MIC) ratio was obtained with enro-C and the highest area under the curve (AUC)<sub>0-72</sub>/MIC ratio with enro-R, and enro-C/Al exhibited an AUC<sub>0-72</sub>/MIC smaller, but Cmax/MIC higher than enro-R. Based on repeated statistical... | Comprehensive estimates of antimicrobial use in Danish companion animals were not readily available due to database construct. Antimicrobials sold for use in companion animals (linked to a companion animal ID) comprised a large number of products licensed solely for horses or livestock, while data assigned a replacemen... | A total of 153 complete responses describing cats with FLAD were analyzed. Glucocorticoids and bronchodilators were the predominantly prescribed therapeutics for 140/153 (92%) and 80/153 (52%) of FLAD cats, respectively. Oral and inhalant administration routes were reported most commonly: glucocorticoids (64% oral and ... | Of 2,324 studies screened, we identified three studies (two randomized and one nonrandomized controlled trial) which met our inclusion criteria for meta-analysis. Studies examined only 26 animals (9 events) across their short-duration arms and 28 animals (17 events) across long-duration arms. All studies were assessed ... | 42110499 | Open research Europe | [
0.6923521757125854,
0.48505401611328125,
0.5428387522697449,
0.500324010848999,
0.49228668212890625,
0.5065920948982239
] |
Title: Breaking the culture habit: Complementing culture-based veterinary diagnostics with metagenomic data -A case study of feline and canine skin infections. Background: Skin infections have been described as the primary cause for veterinary small animal practice visits, frequently requiring topical and systemic anti... | One feline and eight canine skin swabs were analyzed with aerobic culture and traditional antimicrobial susceptibility testing (AST) and compared with MGX profiles. VDL aerobic culture and AST identified Staphylococcus aureus, S. pseudintermedius, S. schleiferi, methicillin resistant (MR) S. schleiferi (MRSS), MR S. ps... | Ten dogs with clinical signs of SA, nine with osteoarthritis (OA, control group) and nine with clinical signs of immune-mediated polyarthritis (IMPA, second control group) were examined. Bacterial culture was positive in seven of 10 dogs with clinical SA, of which only two were positive by 16S rRNA PCR. The sensitivity... | Fecal microbiome diversity after FMT resembled that of the healthy donor dog's fecal microbiome, before FMT, which led us to conclude that the fecal microbiome in our patient normalized with FMT. Moreover, the clinical symptoms improved remarkably with regard to the changes in the fecal microbiome. Additionally, we not... | No isolates from cats were susceptible to amoxicillin-clavulanate (susceptibility [S] ≤ 0.25/0.12) or amoxicillin (S ≤ 0.25); isolates from dogs had low susceptibility to amoxicillin 53% (S ≤ 8). Conversely, isolates from dogs had high susceptibility to amoxicillin-clavulanate 92% (S ≤ 8/4), despite equal 90th percenti... | Significant bacteriuria was detected in 18.4% of samples from dogs and 10.0% from cats, most of which (>90%) yielded a single organism. Escherichia coli was the most prevalent bacterial species (54.7% and 55.6% of feline and canine isolates, respectively) followed by Proteus mirabilis in dog samples (22.7%) and Enteroc... | A reduction in the total clinical score was seen at each time point (D14, P = 0.03; D28, P = 0.04; D42, P = 0.001). A reduction in the regional clinical scores was seen after D28 (P = 0.01) and D42 (P = 0.003). A significant reduction in the pruritus score was seen on D42 (P = 0.01). A lower hydration value was seen on... | 42106812 | BMC veterinary research | [
0.7546526789665222,
0.6082308888435364,
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0.564613401889801,
0.5916602611541748,
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] |
Title: Delta (Δ) 12-lead electrocardiography and vectorcardiography to identify the origin of focally induced atrial and ventricular premature depolarizations in horses. Background: Cardiac arrhythmias are common in horses, but their clinical and prognostic relevance remains poorly defined. Despite the importance of lo... | Distinct pacing sites produced reproducible and location-specific activation patterns. For differentiating left- from right-sided origins, 3D-VCG had 99% and 82% accuracies for ventricular and atrial origins, respectively. The simplified Δ-based 2D-VCG also showed strong performance on the chamber level, with accuracie... | The results show significant differences in electrocardiogram recordings depending on the animal's body position. Those differences mainly concern the amplitude of the P wave and R wave in the recordings and are even more visible comparing the electrocardiograms of the same specimen. There are also some significant dif... | AFR increased from 299 ± 33 fibrillations per minute (fpm) to 376 ± 12 fpm (p < 0.05) and atrial function (active left atrial fractional area change) decreased significantly during the study (p < 0.05). No changes were observed in heart rate or ventricular function. The AF group had more atrial fibrosis compared to the... | The findings that differed from those during the initial examination were that cardiac arrest was observed for approximately 5 sec during auscultation, along with sinus arrest. Therefore, to further investigate for syncope, a Holter electrocardiograph was obtained for 3 days. Consequently, sinus arrest was identified a... | Despite the well-characterized health benefits of BP use in humans, little is known regarding the effects of BPs in the horse. In the equine setting, only non-nitrogen-containing BPs are FDA-approved primarily for the treatment of navicular syndrome. The focus here is to discuss the current understanding of the strengt... | Data collected from 16 rabbits were used for statistical analysis. In the clinical setting, the PetMAP<sup>™</sup> device showed significant overestimation of systolic, diastolic and mean arterial pressure, which were measured in the auricular artery. In addition, the bias was not constant, implying that the device poo... | 42105301 | Journal of veterinary internal medicine | [
0.7266047596931458,
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0.536378026008606,
0.5225145816802979,
0.47311729192733765
] |
Title: Complaints filed with the Veterinary Disciplinary Board in Sweden - a thematic analysis. Background: This study examined complaints submitted to the Veterinary Disciplinary Board for Animal Health Staff in Sweden to identify reporting reasons, case outcomes, and recurring themes. A quantitative compilation and q... | Of 500 cases, 87% did not lead to sanctions, of which 21% (n = 106) were fully dismissed. The sanctions were admonitions (n = 48; less severe), warnings (n = 7; more severe), probations (n = 3) and revoked licence (n = 1). Veterinarians accounted for the majority of reported animal health staff (522/608). Thematic anal... | Out of 312 total respondents, 230 (73.71%) were farmers and 82 (26.28%) were veterinary professionals. From the farmer respondents, 127 (55.22%), 153 (66.52%), and 142 (61.74%) had an awareness of antibiotics and their usage, antimicrobial resistance, and withdrawal period, respectively. Out of 82 veterinary profession... | 84 private veterinary practitioners (PVP) and 133 veterinary nurses (VN) completed the survey. In the majority of vignettes, most veterinary professionals agreed with our classification of best outcome, but several areas of uncertainty were identified. Marked variations in response were found for PVPs in vignettes depi... | Welsh equine owners regarded their horses as members of the family (84.8%). Most sourced antibiotics from their vet (68.9%) with a minority (5.1%) never having done so or having used antibiotics left over (16.6%) and 13.6% would consider changing veterinary practice if they did not receive antibiotics when they request... | Thematic analysis revealed five themes - trust-building/relationships, shared decision-making/empowerment, clear communication, judicious use and concerns surrounding antimicrobial use. Strong veterinarian-client relationships were the underlying factor influencing acceptance of antimicrobial use stewardship principles... | Over 96% of respondents acknowledge the utility of the AWAG in aiding in decision-making and it is reported to facilitate discussions among colleagues and dog caregivers about welfare. While the overall sentiment towards the AWAG was predominantly positive, a minority of users expressed difficulties in using the tool, ... | 42104386 | BMC veterinary research | [
0.674925684928894,
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0.4868314862251282,
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] |
Title: Prevalence of ear disease in small-breed dogs undergoing cone-beam computed tomography for dental procedures. Background: Following periodontal disease, ear disease is one of the most frequently reported diseases in dogs. Ear disease often remains undiagnosed due to the vague or absent nature of its clinical sig... | Ear disease was diagnosed in 151/352 dogs (42.6%), predominantly involving the external ear canal (148 dogs). Thirty dogs had middle ear involvement, and three dogs had inner ear disease; some dogs had ear disease in multiple otic compartments. These findings exceeded previously reported clinical prevalence estimates o... | In this retrospective study, the records of 292 patients aged 7 to 13 years were reviewed. SDC was detected in 39% of patients i.e., 28,8% of observed canines. Reduced coronal mesio-distal diameters of permanent maxillary central incisors, 8.7 ± 0.6 mm versus 8.8 ± 0.7 mm (p < .05), and first permanent molars, 10.0 ± 0... | From a total of 13 patient radiographs, we found types I (6/13), II (6/13), and VII (1/13). The mean pixel values of impacted maxillary unilateral canine teeth were 1972.92 (mesial), 2016.55 (distal), 1990.66 (buccal), and 1904.39 (palatal). The mean pixel values of normal erupted maxillary canines were 1754.93 (mesial... | In this study, we found that the majority of our patients with impacted maxillary canines were female (62.5%). Of the total 108 maxillary impacted canines, 60.2% resorbed the adjacent teeth of the affected quadrants. Lateral incisors were the most affected (34.3%). The mean age of subjects with RR was 16.7 ± 3.5 years.... | After removing 6 duplicates, 3700 articles were identified. For the final analysis, 19 studies published between 1985 and 2023 met all the eligibility criteria and were included. A total of 7 studies presented as good and 12 studies presented as satisfactory. Patients were screened in ten studies and diagnostic records... | The maxillary canine angulation had a significant role in the timing of the canine eruption (estimate 0.06, 95% CI 0.04 to 0.08). While ABG seemed to delay the canine eruption, this result was not statistically significant. The eruption of the maxillary canine tooth on the bone grafted side was delayed compared to the ... | 42100226 | Frontiers in veterinary science | [
0.8058447241783142,
0.5727720260620117,
0.5358875393867493,
0.5804646611213684,
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] |
Title: CSF-net: a color space fusion network with self-attention-driven feature learning for feline ocular diseases classification. Background: Feline ocular diseases can cause irreversible vision loss if they are not detected early. However, early diagnosis is often difficult. This is due to limited access to veterina... | CSF-Net achieves superior performance, reaching an accuracy of 83.05% and achieved a mean fold-wise macro-AUC of 0.9690 across five cross-validation folds. Ablation and class-wise analyses confirm the effectiveness of self-attention in leveraging multi-color representations, while also revealing limitations for eyelid-... | Of the 368 proteins, 84 were detected in CSF and 146 in serum. Eighteen of 84 proteins in CSF and 30/146 in serum were differentially abundant among the 3 groups, after correction for multiple testing. Modeling indicated that a 2-protein test using CSF had the highest accuracy for discriminating among all 3 groups. Cer... | Associated signs of ocular disease in cats with FIP were diagnosed in 33% (20/61) cats, with a median follow-up of 55 days (IQR 47.3-90.8, range: 16-1071 days) in 11 cats with FIP. Ocular changes were all associated with uveitis, of which 20% (4/20) had anterior uveitis, 25% (5/20) had posterior uveitis, and 55% (11/20... | Between January 2009 and August 2024, 16 eyes from 14 dogs (5 male; 35.7% (37.5% eyes), 9 female; 64.3% (62.5% eyes) had a confirmed histopathological diagnosis of cSCC following SK surgery. All cases were diagnosed within the last 9 years. There was a notable predilection of brachycephalic breeds (85.7% of dogs; 81.3%... | Our analysis of the clinical data shows that focal cortical anterior cataracts often associated with anterior uveitis and lesions in the fundus are the most prevalent manifestation of ocular encephalitozoonosis in cats and dogs. Serological testing and PCR analysis of lens material are the most important diagnostic too... | We discuss the strategies for diagnosis, treatment, and common risk factors for ocular Capnocytophaga infections. At-risk patients with ocular infections should be asked about close contact with dogs and cats; and treated promptly with the proper antibiotic regimen. | 42100224 | Frontiers in veterinary science | [
0.6212015748023987,
0.3840561509132385,
0.3813294470310211,
0.3577688932418823,
0.3573659062385559,
0.35456275939941406
] |
Title: Complete blood count-derived inflammatory markers in canine cerebrovascular accidents: diagnostic utility and prognostic implications. Background: Cerebrovascular accident (CVA) is an under-recognized cause of acute neurological dysfunction in dogs. Although magnetic resonance imaging (MRI) supports diagnosis, t... | Dogs with CVA had significantly higher NLR and SII values than healthy controls. The receiver operating characteristic curves yielded areas under the curves of 0.82 (95% CI: 0.68-0.96) for NLR and 0.85 (95% CI: 0.71-0.99) for SII. The optimal cutoffs determined by the Youden index were 3.92 for NLR (sensitivity 70.6%, ... | Several Ct/Cm were detected only in MUE cases: GM-CSF (9/18), IFN-γ (13/18), IL-2 (8/18), IL-15 (4/18), and TNF-α (11/18). Other Ct/Cm concentrations were significantly higher in MUE cases (IL-8: median 101 pg/mL, range 144, p = 0.019; IL-18: median 3 pg/mL, range 0.52, p < 0.001; MCP-1: median 814 pg/mL, range 1319, p... | After recovery significantly higher levels of Th17 (p = 0.0265) and Treg cells (p = 0.00025) were detected compared to acute IVDH but Th17/Treg ratio did not differ significantly. Recovered dogs and the control group did not differ significantly from each other. No association between an imbalance in the ratio and neur... | Of the dogs tested, 112 (83.6%) were seropositive and 77 (68.8%) were PCR-positive (<i>E. canis</i>: 27; <i>A. phagocytophilum</i>: 29; co-infection: 21). The co-infected group had the highest levels of CRP (135.2-154.8 mg/l) and TNF-α (161.5-174.0 pg/ml), significantly exceeding those of CME (104.6-120.9; 148.7-162.2 ... | Six dogs and 2 cats experienced cardiopulmonary arrest or anesthetic complication in a veterinary hospital and were promptly resuscitated. Seven showed progressive neurological improvement within 72 hours of the hypoxic-ischemic insult. Four fully recovered and 3 had residual neurological deficits. One dog presented co... | The prevalence of VBP was 19.6% in the CCLR group and 18.8% in the control group, with no statistical difference among them. The presence of synovitis was not more frequent in CCLR dogs (45.6%) than in control dogs (43.7%). Lymphoplasmacytic infiltration was the most common inflammatory pattern detected in the joints o... | 42100222 | Frontiers in veterinary science | [
0.5712137818336487,
0.507024347782135,
0.5216866135597229,
0.529413640499115,
0.5129145383834839,
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] |
Title: Remineralization of early caries lesions by calcium hypophosphite in vitro: a surface microhardness study. Background: This in vitro study used a pH cycling model to compare the caries remineralizing efficacy of toothpaste formulations containing calcium hypophosphite (CaP), hydroxyapatite (HAP), or sodium fluor... | All groups exhibited significant (paired t test, p < 0.001) increase in SMH from baseline, indicating remineralization. Combining CaP and HAP achieved significantly (ANOVA/Tukey's, p < 0.001) greater %Rem (89.7 ± 3.3) when compared with CaP alone (75.4 ± 5.5), HAP alone (62.4 ± 4.8), or NaF alone (60.3 ± 7.8). While %R... | Recombinant amelogenin peptide TRAP adsorbed onto HA and demineralized enamel surfaces. After in situ analysis, all samples hardened significantly compared with baseline. Fluoride had a significantly greater effect than all other treatments. %SMHR was significantly greater than the DDW for the recombinant amelogenin pe... | The ΔE of the low-concentration peptide-HAP suspension did not differ from that of VS. Application frequency, exposure time, and storage in saliva did not have any significant impact on whitening efficacy of the peptide-HAP suspension. Increasing the concentration of the suspension did not promote overall ΔE. SEM obser... | ΔF value presented a significantly decreasing trend throughout the 21 days for all groups except the Duraphat and Enamel Pro varnishes. The changes between 14th and 21st days of the Clinpro XT varnish application were significantly higher than Emdogain, Curodont, and Enamel Pro. The Curodont group showed higher lesion ... | After treatments, the KHN was similar to the baseline in all groups. After the second cariogenic challenge, it was observed that G1, G4 and G5 presented KHN similar to their baseline numbers, and in G2 and G3 the KHN was similar to the post-treatment numbers. In general, the recovery of enamel hardness after treatment ... | For the enamel and considering the erosive-abrasive cycle, significant differences were found between the groups tested, the bleaching, and the abrasiveness of the dentifrice tested; however, the final microhardness values were significantly lower than the initial ones. For dentin, differences were found between the er... | 42098072 | BDJ open | [
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0.5355420112609863,
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] |
Title: Retrospective Analysis of Epidemiologic, Clinical, and Laboratory Findings of Patients Diagnosed with Brucellosis and Review of the Literature. Background: Brucellosis has significant public health and human health consequences. It causes significant economic hardship, especially in areas where food safety measu... | The study included 748 patients diagnosed with brucellosis. Of these, 484 (64.7%) were female, and the mean age was 39.2 ± 15.0 years. A significant proportion of patients (91%) lived in rural areas. Regarding transmission routes, 79.4% of patients reported consuming unpasteurized fresh cheese. Patients were categorize... | The results showed that the multiepitope-based fusion protein performed best in distinguishing brucellosis-positive and brucellosis-negative dog sera, with a positive predictive value (PPV) of 100% and a negative predictive value (NPV) of 98.41%. BP26 and Omp31 showed excellent sensitivity in detecting brucellosis-posi... | For BRD diagnosis in calves, clinical examination (36.8%), necropsy (33.7%), and rectal temperature (31.6%) were the tools most regarded as extremely important. Oxytetracycline was the most commonly used primary antibiotic (52.6%), tulathromycin was the secondary option (38.9%), and NSAIDs were represented as the most ... | The literature search resulted in 776 outputs of which 132 conformed to the predefined criteria. The average zonal prevalence of meat inspection-based BCC ranged from 2% in Buno-Bedele to 24.6% in Sidama zone. The pooled prevalence of BCC was influenced by the number of muscle/organs inspected, ranging from 3.4% (95% C... | For bovine serum, the combined protein group (ErfK + YxeI + EntF) and YxeI demonstrated the highest diagnostic accuracy of 94.23% and 93.58%, respectively. Meanwhile, the combined protein group showed the strongest ability to detect <i>Brucella</i> in sheep serum, achieving an accuracy of 88.10%. Both the combined prot... | Neurobartonelloses included neuralgic amyotrophy, complex regional pain syndrome, chronic inflammatory demyelinating polyneuropathy, cranial nerve paralysis, Guillain-Barré syndrome, peripheral vasculitic polyneuropathy, acute transverse myelopathy, neuroretinitis, encephalitis/encephalopathy, cerebral vasculitis/aneur... | 42094255 | Infectious diseases & clinical microbiology | [
0.7417951822280884,
0.55857914686203,
0.43002280592918396,
0.4983823001384735,
0.5006712675094604,
0.4398382902145386
] |
Title: Case Report: Resolution of a cutaneous infection with methicillin-resistant <i>Staphylococcus pseudintermedius</i> with topical therapy in a cat with pemphigus foliaceus. Background: Pemphigus foliaceus (PF) is the most common autoimmune skin disease in cats. Long-term immunosuppressive therapy increases suscept... | This case suggests that localized MRSP skin infections in selected feline patients receiving immunosuppressive therapy may be successfully managed with topical-based management alone. Such an approach supports antimicrobial stewardship in veterinary medicine, highlighting that topical therapy may be considered a reason... | The proportion of cats free of detectable fleas exceeded 91% by Day 7 and approached 95% by Day 30 post-treatment. Significant clinical improvement was observed during the first two weeks, including reductions in pruritus intensity and dermatological lesion scores. Treatment response did not differ according to sex or ... | One feline and eight canine skin swabs were analyzed with aerobic culture and traditional antimicrobial susceptibility testing (AST) and compared with MGX profiles. VDL aerobic culture and AST identified Staphylococcus aureus, S. pseudintermedius, S. schleiferi, methicillin resistant (MR) S. schleiferi (MRSS), MR S. ps... | Histopathological results showed that colonies of MRSP reached the superficial dermis and entered hair follicles. Co-treatment with fusidic acid and phage significantly reduced the amount of MRSP after 8 h. In conclusion, topical co-treatment with fusidic acid and a phage could be a promising approach to the treatment ... | The minimum inhibitory concentrations of different antibiotics for Staphylococcus spp., Enterobacteriaceae, and Enterococcus spp. were determined to establish representatives of different antibiotic classes relevant for treatment or surveillance. For Coagulase-positive and Coagulase-negative Staphylococci, resistance t... | We discuss the strategies for diagnosis, treatment, and common risk factors for ocular Capnocytophaga infections. At-risk patients with ocular infections should be asked about close contact with dogs and cats; and treated promptly with the proper antibiotic regimen. | 42078849 | Frontiers in veterinary science | [
0.728826105594635,
0.5253329873085022,
0.5610048770904541,
0.5612807869911194,
0.5296881198883057,
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] |
Title: A rapid isothermal RPA-CRISPR/Cas12a assay for detection of <i>Rickettsia rickettsii</i>. Background: Rocky Mountain spotted fever (RMSF) resulting from the tick-borne <i>Rickettsia rickettsii</i> infections is a potentially fatal tick-borne disease affecting humans and dogs in the Americas. It is difficult to c... | Using quantified synthetic DNA (gBlock) standards derived from the <i>R. rickettsii</i> Sheila Smith <i>vut</i> target region, the assay was able to detect target DNA in about 40 min at 37 °C with an observed analytical detection limit of 60-70 copies per reaction. Specificity testing on four <i>R. rickettsii</i> strai... | <i>T. vivax</i> was detected in 0.40% (1/246) of the samples, while <i>B. bigemina</i> and <i>B. bovis</i> were detected in 20.62% (33/160) and 11.87% (19/160) of the samples, respectively. It was found that there was a reduction in mean corpuscular volume in animals that presented with co-infection and those infected ... | The amplicon sequences obtained from both cases were 100% identical, indicating that the infections in both dogs were caused by the same organism. BLAST analysis against the GenBank nucleotide database showed a 100% match with O. osleri, thereby confirming the diagnosis. PCR testing for O. osleri is feasible on genomic... | The developed assay demonstrated high analytical sensitivity, detecting 1,060 copies/μL for CDV, 11,403 copies/μL for CAV-2, and 11,016 copies/μL for Bb, with 100% specificity and no cross-reactivity with non-target organisms. The assay was validated on 55 clinical samples of dogs suspected with CIRDC, the assay detect... | Blood samples (n = 338) aseptically collected from suspected dogs of Central Plain Zone of Punjab state, India were subjected to SYBR Green based real-time duplex PCR assays for simultaneous detection of B. vogeli & E. canis and B. gibsoni & H. canis. Results revealed an overall prevalence rate of canine tick-borne hae... | This novel method demonstrated high sensitivity and specificity,achieving a detection limit of 24 copies/mL for each pathogen. Furthermore, the assay exhibited excellent reproducibility, with coefficients of variation below 1.5%, a strong linear correlation (R<sup>2</sup> > 0.996), and an amplification efficiency betwe... | 42078533 | Frontiers in microbiology | [
0.6258556246757507,
0.37889790534973145,
0.38809433579444885,
0.38256773352622986,
0.39802050590515137,
0.39893174171447754
] |
Title: Modulation of the endocannabinoid system reduces inflammatory signalling in canine mammary carcinoma cells. Background: Canine mammary carcinoma (CMC) is characterised by a chronic inflammatory microenvironment resembling human breast cancer; however, the upstream regulatory mechanisms driving this phenotype rem... | Canine mammary carcinoma-derived cells exhibited significant overexpression of ECS receptors (CB1, CB2, TRPV1, GPR55 and PPAR-α) compared to normal controls. These cells also showed increased secretion of pro-inflammatory cytokines, including IL-6, IL-8, TNF-α and IL-17A. Treatment with CBD at 10-20 µM significantly do... | Significantly extended survival was observed in mouse P815 and 4T1 tumor models. Complete tumor regressions were observed in all three non-human species (6/186 (3%) of mouse mastocytomas; 3/14 (21%) of canine mastocytomas and 2/11 (18%) of equine melanomas). Evidence of systemic immune responses (regression of non-inje... | Activated canine non-B, non-T NK cells (CD3<sup>-</sup>CD21<sup>-</sup>CD5<sup>-</sup>TCRαβ<sup>-</sup>TCRγδ<sup>-</sup>) for 13~17 days ex vivo showed ADCC ability against trastuzumab- or cetuximab-coated target tumor cells expressing various levels of human epidermal growth factor receptor 2 (HER-2) and epidermal gro... | A total of 20 dogs diagnosed with solid tumors were recruited and treated in the study. Tumors treated included Soft Tissue Sarcoma (<i>n</i> = 15), Mast Cell Tumor (<i>n</i> = 3), Osteosarcoma (<i>n</i> = 1), and Thyroid Carcinoma (<i>n</i> = 1). HIFU was well tolerated with only 1 dog experiencing a clinically signif... | The overall response rate was 14.7%, with a best overall response rate of 16.7%. Treatment-related adverse events occurred in 40.0% of the dogs, which were primarily grade 1-3. Increased baseline white blood cell, neutrophil count, and C reactive protein levels were significantly associated with poor response, shorter ... | Unexpectedly, disease-free survival and overall survival were statistically inferior for dogs in the intent-to-treat population compared to a well-validated historical control cohort, so the trial was halted for futility. Cytotoxicity assays of PBMCs showed significant decreases after both surgery and chemotherapy with... | 42078490 | Veterinary record open | [
0.8136641383171082,
0.4723246693611145,
0.4504454433917999,
0.43694454431533813,
0.4620949625968933,
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] |
Title: Combination Therapeutic Effect of Antibacterial and Antiviral Agents on Feline Chronic Gingivostomatitis Nonbounded to Prior Tooth Extraction Confirmed by Physical Signs and Clinical Biomarkers. Background: Feline chronic gingivostomatitis (FCGS) is refractory stomatitis in cats. The cure rate of tooth extractio... | Mass spectrometric analysis revealed the active ingredients of antibacterial and antiviral were Moxifloxacin and Molnupiravir, respectively. All physical signs (weight, appetite, activity level, grooming behavior, ptyalism, erythema) showed statistically significant improvements with combined administration of these dr... | Overall, 15 studies met the inclusion criteria. Several important genes were highlighted and mutations and polymorphism in these genes showed an increase in the risk of tooth impaction. Specifically, MSX1 rs12532, PAX9 rs4904210 and rs2073247, AXIN2 rs2240308, as well as MSX2 rs4868444 and ARNT2 rs140220410 revealed si... | In comparison with baseline, duration of "not pawing the face" was significantly shorter at day 3 in G2. These cats spent significantly longer time "standing" and "laying" at days 3 and 6, respectively; G1 spent significantly less time "walking" and "standing" at days 3 and 4, respectively and significantly longer time... | Cats received treatment with different combinations of IV remdesivir, SC remdesivir, and PO GS-441524 at a median (range) dosage of 15 (10-20) mg/kg. Clinical response to treatment was observed in 28 of 32 cats (87.5%) in a median (range) of 2 (1-5) days. Twenty-six of 32 cats (81.3%) were alive and in clinical and bio... | Cats with FIV developed FIP at an older age and longer after retrovirus infection than cats with FeLV. The average starting dosage (7 mg/kg/d) was increased in 65% of cats, and treatment was extended in 35%. Three cats relapsed (18%). There was a 94% (16/17) twelve-week survival rate and 82% (14/17) one-year survival r... | Sixty-three case reports are included in this review. Fifty-nine out of the 63 cats were from Europe, mostly from Mediterranean countries (88.9%). Most of them were domestic short-haired cats (90%) with a mean age of 7.9 years, and had access to the outdoors (77.3%). Sixty-six percent of the cats had comorbidities, of ... | 42076735 | Veterinary sciences | [
0.5390885472297668,
0.460845023393631,
0.45850154757499695,
0.5025339126586914,
0.47387731075286865,
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] |
Title: TRBC1/TRBC2 RNA In Situ Hybridization as a Diagnostic Approach for Canine and Feline T-Cell Lymphoma: A Proof-of-Concept Study. Background: T-cell lymphomas are relatively common in veterinary species, yet current diagnostic tools such as PCR-based clonality assays often lack sensitivity and specificity. In huma... | In normal tissues, we found the <i>TRBC2</i>:<i>TRBC1</i> expression ratio to be similar to the 1.2:1 ratio in humans, between 1:1 and 3:1, skewing towards <i>TRBC2</i>, in both dogs and cats. These findings were corroborated using quantitative reverse transcription PCR. Applying our in situ hybridization probes to cas... | To the authors' knowledge, this is the first time multicentric lymphoma is diagnosed in donkeys. Further studies of the genetic background, clinical, laboratory, histopathologic, and immunohistochemical, as well as the pathogenesis of lymphoma, is needed to better understand the uniquely low frequency of this neoplasm ... | Among 28,681 canine cases referred to the Department of Veterinary Pathology, University of Zagreb, from 2009 to 2023, a total of 374 cases (1.30%) were diagnosed with lymphoma. Of these, 282 cases (75.40%) were purebred dogs, with the most affected breeds being Golden Retrievers (23, 6.15%), Labrador Retrievers (23, 6... | Within the canine lymphoma group, HERC5 showed consistent upregulation, a gene similarly implicated in human acute myeloid leukemia but previously no reports exist. Additionally, noteworthy genes, including IKZF2, CCL4, SAA1, and CD40, exhibited differential expression in the TCL group compared to the B-cell lymphoma (... | To this end, we developed and validated a triplex TaqMan probe-based real-time PCR assay for the simultaneous detection and differentiation of SIV, PRRSV, and PCV2. This assay demonstrated high specificity, with no observed cross-reactivity between the target viruses. The assay's sensitivity was determined to be 100 co... | In canine meningiomas (n = 7), RNA expression of SSTR1, SSTR2 and SSTR5 was detected in all samples; SSTR3 RNA expression was detected in only 33% of samples. In feline meningiomas (n = 12), RNA expression of SSTR1, SSTR4, SSTR5 and SSTR2 was detected in 91%, 46%, 46% and 36% of samples, respectively; SSTR3 was not exp... | 42076702 | Veterinary sciences | [
0.8650645017623901,
0.49342209100723267,
0.5329800248146057,
0.5362321734428406,
0.5457156300544739,
0.49566325545310974
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Title: Standing NanoNeedle Arthroscopy of the Distal Interphalangeal Joint for Removal of Osteochondral Fragments of Distal P2 and the Extensor Process in a Horse. Background: In horses, standing arthroscopy offers a valuable alternative to general anesthesia for the reduction of anesthetic-associated risks, and provid... | This case demonstrates the feasibility of standing NanoNeedle arthroscopy of the equine coffin joint with improved maneuverability, surgical ergonomics, and reduced iatrogenic injury compared to a standard rigid arthroscope. The successful execution of this technique effectively expands our collection of standing arthr... | Nineteen horses completed the study, with no complications following the biopsies and treatments. No significant differences in the trabecular bone parameters or bone formation rate were observed between treatment groups. The use of a first-generation bisphosphonate may mean some effects of these drugs are underreprese... | APS did not decrease lameness or joint circumference compared with untreated controls. Synovial fluid parameters were not different between treatment groups. APS treatment did significantly decrease gross and histopathology scores. Main limitations included the use of an induced model of the synovitis, inter-horse vari... | Short-term complications were few; at 24 h minor swelling occurred in 29 and 33% of horses sutured with KBS and SS respectively and cutaneous dehiscence during recovery occurred in two horses of each group. Post-discharge follow-up revealed that three horses needed veterinary attention for treatment of complications (s... | Dogs treated with four weekly injections of HA or two biweekly injections of HA-PRP were significantly (p < 0.05) better than dogs treated with four weekly injections of saline at 2-, 4-, and 12-week time points based on a comfortable range of motion (CROM) and clinical lameness score. Gait analysis measuring symmetry ... | Values recorded on the lateral view were higher than those on the dorsoventral view. No differences or correlations were found between Orthopedic Foundation for Animals hip grades and temperature. Digital thermographic images showed a weak significant correlation with weight-bearing evaluations (r = 0.13, p < 0.01) and... | 42071937 | Animals : an open access journal from MDPI | [
0.6641926169395447,
0.5118712782859802,
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Title: Upregulation of Sox2 Following Saracatinib Treatment Contributes to a Resistant Phenotype in Colorectal Cancer Cells under Growth Factor-Supplemented Conditions. Background: Increased Src kinase activity is known to correlate with cancer progression and poor prognosis, indicating that Src plays a central role in... | Saracatinib significantly reduced cell viability and migration in both cell lines, predominantly through the induction of apoptosis. Spheroid formation was less efficient under GF-supplemented conditions than under FBS-supplemented conditions. The anti-cancer effects of saracatinib were mediated through inhibition of p... | A novel gastric carcinoma cell line, designated MCC, was established from BALB/c mice. This cell line exhibited a doubling time of approximately 33 h. Genomic and proteomic analyses identified mutations frequently observed in clinical gastric cancer patients, such as Kras, Egfr, and Ccnd3. Additionally, MCC overexpress... | While ZA application did not show a significant cytotoxic effect in the cells in the first 24 h, a decrease observed in the viability of the cells depending on the increasing dose and time. Low dose ZA (1, 5, 7.5, 10 µM) concentrations increased mineral content and alkaline phosphatase enzyme activity. A significant de... | This study successfully developed PBSO NPs with favorable morphology and physiological stability, capable of enhancing cellular uptake. In vitro experiments demonstrated that PBSO NPs significantly inhibited the viability, migration, and invasion of Panc02 cells while promoting apoptosis. Moreover, PBSO NPs enhanced th... | The results showed that cells treated with 10 µg/mL DOXO showed a 71.64% reduction in cellular growth after 72 h of treatment. Reductions in the expression of VEGF and PCNA-3 were observed by flow cytometry in all treatments when compared to the control. The intracellular levels of ERs were also significantly increased... | CXCR3 expression was significantly higher in CIPm than in CIPp cells. In both the cMGT cell lines, CXCL10 treatment reduced CXCR3 expression on the cell membrane in a dose- and time-dependent manner. The CXCR10/CXCR3 axis promoted cell proliferation and migration in cMGT cells. CXCL10/CXCR3 interaction upregulated the ... | 42065072 | Oncology research | [
0.7419459819793701,
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0.41817060112953186,
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Title: Diagnostic performance of lung ultrasound compared to thoracic radiography in non-traumatized dogs and cats with respiratory distress in an emergency setting. Background: Respiratory distress is a medical emergency requiring rapid diagnostic decision-making. This prospective observational study evaluated the eff... | A total of 144 animals (83 dogs and 61 cats) with acute respiratory distress were included. The suspected diagnosis based on LUS was concordant with the definitive diagnosis in 80.6% of cases, while TXR achieved 89.1%. Both modalities were correct in 77.5% of cases, and at least one modality was correct in 92.2%. Diagn... | In total, 35 cats were included: 18 with definitive FIP and 17 with presumptive FIP. Radiographs were abnormal in 32/35 cats and normal in 3/35 cats. Pleural effusion was present in 13/35 cats and was either bilateral (11/13) or unilateral (2/13) in distribution. The lungs were radiographically abnormal in 25/35 cats, ... | The findings of this study revealed that CBCT provided superior accuracy in assessing the position of impacted canines compared to Panoramic Radiography. Specifically, CBCT demonstrated a mean accuracy rate of 89.5%, while Panoramic Radiography showed a mean accuracy rate of 72.3%. Moreover, CBCT allowed for better vis... | Medical records of 21 client-owned cats with CHF (median age = 10.6 years [interquartile range (IQR) = 6.5-11.2]) receiving torasemide were reviewed. Data collected included torasemide dosages, other concurrent medications, physical examination features, echocardiographic data, and potential adverse effects during foll... | B-lines and shred signs with or without bronchograms were identified on LUS in 14 of 17 and 16 of 17, at admission. Chest radiographs and LUS scores differed significantly using both canine AP scoring systems at each time point (18 regions per dog, P < .001). Clinical and CRP normalization occurred in all dogs during f... | Across probabilistic simulations, CT-only and unconditional-CTM were consistently less effective and more costly than other options and therefore were never preferred (strictly dominated). Magnetic resonance imaging-only was less cost-effective than strategies based on noncontrast CT (extendedly dominated). Conditional... | 42063420 | Frontiers in veterinary science | [
0.7240054607391357,
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0.4874928891658783,
0.62043696641922,
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] |
Title: CAR-T cells targeting fibroblast activation protein eliminate pathological fibroblasts and preserve cardiac function in a Duchenne Muscular Dystrophy murine model. Background: Chimeric Antigen Receptor (CAR)-T cells therapy has revolutionized the treatment of hematological cancers and are currently redirected to... | In vitro anti-FAP CAR-T cells were successfully activated when co-cultured with FAP + target cells. In a dystrophic murine model (D2.mdx), anti-FAP CAR-T cells, intravenously delivered following lymphodepletion, homed to the heart and skeletal muscles, where they decreased FAP and fibrosis-associated genes. Single-cell... | 25 μM DFO pretreatment significantly up-regulated immunomodulatory genes (Tgfb, Hgf, and Tsg-6) in fATMSCs. In the mouse ALI model, DFO-pretreated fATMSCs exhibited enhanced anti-inflammatory effects, reducing inflammatory cytokines (Tnfa, Il1b, Il6). Clinical safety assessment in felines showed no immediate adverse ef... | Transcript for VEGFR2, PDGFRα, PDGFRβ, and KIT was detected in all UC tissue samples and UC cell lines. The Proteome Profiler™ Human Phospho-RTK Array Kit (R & D Systems) provided a platform to assess phosphorylation of 42 different RTKs in primary UC tumors and UC cell lines. Evidence of PDGFRα and PDGFRβ phosphorylat... | We found: (1) substantial differential expression biases in feline orthologs of human oncogenes and tumor suppressor genes suggesting conserved functions in FISS; (2) a genomic region with recurrent SCNA in human sarcomas that is syntenic to a feline genomic region of probable SCNA in FISS; and (3) significant overlap ... | We identified a novel circular RNA circCPE by analyzing circRNAs sequencing data of bovine muscle tissue. Sequencing verification, RNase R treatment and Actinomycin D treatment confirmed the circular nature of circCPE in bovine muscle. Functional assays showed that overexpression of circCPE could inhibit bovine myoblas... | IDO-1 expression and kynurenine production in fAdMSCs were increased significantly by a poly (I:C) treatment and enhanced using a basic fibroblast growth factor (bFGF) treatment. The level of fAdMSC aggregation increased IDO-1 expression significantly compared to the monolayer. These effects were enhanced by pretreatme... | 42063173 | Stem cell research & therapy | [
0.7936643362045288,
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Title: "Not a problem because we drench for it": the management of liver fluke on sheep farms. Background: <i>Fasciola hepatica</i> (liver fluke) imposes major productivity and welfare costs on ruminant systems and is increasing in temperate regions such as the UK. In the absence of vaccines, control on sheep farms rem... | Despite heterogeneous farm types, farmers described fasciolosis as a "high stakes, low certainty" problem characterised by diagnostic ambiguity, limited confidence in test results, and difficulty distinguishing fluke impacts from other causes of ill-thrift. This uncertainty promoted risk-averse practises, with flukicid... | A sharp overall increase in the dictyocaulosis diagnostic rate (DR, cases / 1000 submissions) was observed, with, for example, median 2010-2014 DR 3.5 times as high as 1980-1984 DR. Such increases were most pronounced for Scotland, which became the region with the highest proportion of cases by 2009. Cases were increas... | Medical records of 187 goats and 434 sheep were included in the analysis of this study. Females were significantly more represented in the study population for goats and sheep, 87.70% and 84.10%, respectively. The age of animals ranged between 1 day and 9 years in goats and 1 day and 7 years in sheep. In both goats and... | Results showed high education and knowledge levels. According to the respondents, antibiotic treatment advice was almost always provided to the farmers, and the recommended treatment was most commonly based on recommendations for the specific disease. However, farmers had almost never had their animals properly diagnos... | Most of the farmers encountered were older males (56%) aged over 65 years. Helminth eggs were identified in sheep faecal samples, revealing four genera: <i>Haemonchus</i> spp. (100%), <i>Strongyloides</i> spp. (67%), <i>Moniezia</i> spp. (61%) and <i>Trichuris</i> spp. (17%). A total of 15 anthelmintic drug brands were... | In a cohort of 174 predominantly middle-aged, female, and Caucasian patients, we found high rates of essential hypertension, neoplasms, heart disease, liver disease, and sleep disorders. Key symptoms included upper abdominal pain, skin complaints, dyspnea, and malaise/fatigue. Some outcomes were hepatomegaly, cholelith... | 42058560 | Frontiers in veterinary science | [
0.7189667224884033,
0.4676274359226227,
0.40907078981399536,
0.4515796899795532,
0.4277838468551636,
0.49264365434646606
] |
Title: Characterising Reference Intervals in Clinically Normal Red Wolves (Canis rufus): A Baseline for the Detection of Clinical Disease. Background: The American red wolf (Canis rufus) is a critically endangered canid that has been extirpated throughout most of its historic range in the United States. To counter the ... | The clinical reference intervals developed by this study offer the first set of healthy, species-specific baselines to diagnose disease that may better serve veterinary clinicians in earlier detection of illness and initiation of treatment, which is likely to improve long-term clinical outcomes and disease management i... | Among the 109 blood samples presented at Small Animal Clinics, Teaching Veterinary Clinical Complex, Guru Angad Dev Veterinary and Animal Sciences University, Ludhiana, Punjab (India) tested, 39 revealed colour change from orange to green indicating positive reaction while 70 were negative as revealed by no colour chan... | A total of 39 dogs were enrolled in the study, with a mean age of 115 months and a mean weight of 29 kg at the time of diagnosis. The most common breed was the German Shepherd (<i>n</i> = 9/39). In the IVDP- group (<i>n</i> = 28/39), the median survival time was 13 months (95% CI: 9-18 months) from the onset of clinica... | PCR assays revealed four tick-borne pathogens, Babesia spp., Ehrlichia canis, Hepatozoon canis, and Anaplasma platys, with prevalence rates of 26.09%, 5.87%, 3.52%, and 2.93%, respectively, and an overall prevalence of 31.09% (95% CI: 26.27-36.34%). However, this study could not identify the prevalence of Borrelia burg... | Twelve farms (6 sheep and 6 goat farms) were included based on clinical suspicion of AR. Treatments were carried out with either benzimidazoles (BZ) or macrocyclic lactones (ML) Treatment was effective in 3/6 goat trials, with reduced effectiveness to BZ in two farms and to ML the last one. In sheep farms (6/6), effect... | All haematological values remained within normal range for the study population. Histological analysis revealed that treated group animals had 62 per cent less lobular inflammation, 55 per cent less pigment accumulation, 65 per cent less steatosis and 57 per cent less portal inflammation than control group animals, wit... | 42057642 | Veterinary medicine and science | [
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0.46345001459121704,
0.4725167155265808,
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0.4702225625514984,
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] |
Title: A Botanical Mixture of Boswellia serrata, Commiphora myrrha, Propolis and Scutellaria baicalensis Reduces Expression of Inflammatory Chemokines in Canine Keratinocytes In Vitro. Background: Botanical ingredients can function as adjunctive therapies for managing inflammatory skin diseases. This study aimed to inv... | HPLC analysis identified four components in YSK‑AB, including 6‑hydroxy‑2,6‑dimethylhepta‑2,4‑dienal, baicalin, galangin and AKBA. CPEKs treated with 100, 150, 200 and 250 µg/mL of YSK‑AB exhibited significantly higher viability than that of the control group. In addition, YSK‑AB treatment (50, 100 and 200 µg/mL) signi... | Our data show an increase in blood eosinophils, monocytes, and basophils with a concomitant, significant increase in associated cytokine, chemokine, and immune cell receptor mRNA expression levels in the lesional skin of IBH horses. Moreover, IL-5Ra, CCR5, IFN-γ, and IL-31Ra were strongly associated with IBH severity, ... | Among the cutaneous cell types investigated, there was a decrease in the number of T-box transcription factor TBX21 (Tbet<sup>+</sup>) (p = 0.016), GATA binding protein 3 (GATA3<sup>+</sup>) (p = 0.016), interleukin (IL)-17A<sup>+</sup> (p = 0.03) cells and neutrophils (p = 0.008) after treatment, whereas there were no... | Propolis showed promising activity, with an MLC of 1.25 mg/ mL for feline isolates and 0.16 mg/mL for bovine isolates after 48 h. Ronidazole demonstrated reduced efficacy against feline isolates (MLC 32 μg/mL), suggesting partial resistance, whereas bovine isolates remained susceptible (MLC 1 μg/mL). | The ovalbumin-treated groups exhibited clinical cAD symptoms, such as pruritus and erythema. Moreover, plasma levels of the cAD markers immunoglobulin E and CCL17 chemokine were higher in the ovalbumin-treated group than in the vehicle control group. The skin thickness of the epidermis was significantly increased in th... | It was found that AR-B treatment enhanced the wound healing process. AR-B treated groups showed reduced MDA and NO in tissue, and SOD activity was increased. Re-epithelization and extracellular matrix deposition were significantly improved, which was confirmed by the increase in TGF-β and α -SMA as well as increased co... | 42057627 | Veterinary medicine and science | [
0.5423873066902161,
0.4648873805999756,
0.41858577728271484,
0.41824960708618164,
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] |
Title: Diagnostic Investigation of Two Cases of Oslerus osleri Infection in Dogs: Microscopic Challenges and Molecular Characterisation. Background: The diagnosis of certain lungworm infections in dogs relies heavily on bronchoalveolar lavage (BAL) cytology or lesion histopathology, especially in situations in which fa... | The amplicon sequences obtained from both cases were 100% identical, indicating that the infections in both dogs were caused by the same organism. BLAST analysis against the GenBank nucleotide database showed a 100% match with O. osleri, thereby confirming the diagnosis. PCR testing for O. osleri is feasible on genomic... | A total of 2280 blood samples and six adult worms from pet and shelter dogs were collected in the central and eastern regions of Lithuania in 2013-2015. Based on their morphological appearance, morphometric measurements and molecular analysis, all the adult nematodes were identified as Dirofilaria repens. The diagnosis... | Dogs were presented between March and August (9) and September and January (40) in the years 2015-2021. Historical and clinical findings were lethargy (100%), pale mucous membranes (63%), fever (50%), and pigmenturia (52%). Common clinicopathological findings were thrombocytopenia (100%), anemia (85%), intravascular he... | A total of 4692 fecal flotation test results were obtained, with a majority comprised of client-owned dogs (3262; 69.52%), followed by research dogs (375; 8.00%), and shelter dogs (122; 2.60%). Samples from 976 (20.80%) dogs were positive for at least one parasite, and co-infections of two or more parasites were found ... | PCR, multiple sequence alignment, and phylogenetic reconstruction confirmed the presence of <i>H. placei</i> in the abomasal samples and further confirmed the species as a distinct species of bovine worms at the abattoir. Multiple sequence alignment also revealed genetic sites that can be employed to distinguish <i>H. ... | Microscopic detection and morphological identification of the worms removed during the bronchoscopy confirmed the presence of female adult worms. The subsequent molecular characterisation of the mitochondrial (cytochrome c oxidase subunit I gene (cox1) and 12S ribosomal DNA (rDNA)), nuclear (18S rDNA) genes, as well as... | 42053983 | Veterinary medicine and science | [
0.7766422629356384,
0.5288339853286743,
0.5359811782836914,
0.5242977738380432,
0.48330432176589966,
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] |
Title: Neurological Disorders in Dogs: A Retrospective Analysis of Prevalence, Aetiology, Lesion Locations, and Regional Variations in Northeastern Iran. Background: Neurological disorders in dogs are a significant concern in veterinary medicine and affect various breeds and ages. Previous studies have reported differi... | The prosencephalon was the most commonly affected location (81 cases, 19.6%), followed by multifocal involvement (62 cases, 15%) and the T3-L3 spinal cord (56 cases, 13.5%). Infectious diseases, especially canine distemper diseases, were the most common cause, accounting for 136 cases (33.2%). Unknown causes ranked sec... | Most cases (79.6%) were classified as early IRIS stages (1 and 2) and 20.5% in advanced stages (3 and 4). Smaller sized dogs and mixed breeds represent approximately 50 and 38% of the enrolled cases, respectively. Mean age of cCKD diagnosis was 10.7 years. Statistical analysis showed that larger-sized dogs develop CKD ... | Electronic clinical records at our veterinary referral hospital between April 2009 and November 2018 were searched for patients presented with cervical myelopathy secondary to an underlying suspected vertebral malformation/instability. Nine dogs met the inclusion criteria. Two dogs were diagnosed with atlantoaxial pseu... | Eighty-two percent (366/447) of dogs with presumptive MUO survived to discharge and 63.5% (284/447) were alive at 6 months; 36% of the latter (103/284) had persistent neurological deficits. Breed (pugs; P = .03), epileptic seizures (P < .001), paresis (P < .001), and higher neurodisability scale (NDS) score (P < .001) ... | Overall, 54 dogs (74%) were classified as abnormal MRI, and 19 dogs (26%) were classified as normal MRI cases. Death caused by MUE occurred in 1/19 (5%) normal MRI dogs and 18/54 (33%) abnormal MRI dogs (P = .016). Median survival was >107 months in both groups, but survival was significantly longer in the normal MRI g... | Sixty-three dogs were included: 60/63 (95 %) were large breeds, with Doberman Pinschers and males over-represented (70 %). Mean and median age at the time of diagnosis was 7.25 and 7.2 years (range 0.41-12 years). Chronic signs were noted in 52/63 (83 %) dogs, with proprioceptive ataxia the most common. Main site of sp... | 42048063 | Veterinary medicine and science | [
0.6682689785957336,
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0.551337718963623,
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] |
Title: Efficacy of Credelio Quattro™ chewable tablets containing lotilaner, moxidectin, pyrantel, and praziquantel against Ctenocephalides felis and Rhipicephalus sanguineus infestations on dogs. Background: Fleas and ticks can be found globally and are of both veterinary and human health concern due to their ability t... | Credelio Quattro demonstrated 100% (P < 0.0001) efficacy against C. felis, with no live fleas recovered at time points evaluated through 36 days post-treatment. Additionally, Credelio Quattro demonstrated 97.1-100% (P < 0.0001) efficacy through Day 30 against the established dose-limiting tick species, R. sanguineus. I... | In regions with high endemic disease prevalence in dogs and domestic vectors, prevalence of infected dogs initially increases but subsequently declines before eventually rising back to the initial equilibrium following one fluralaner treatment. In regions of low prevalence and domestic or sylvatic vectors, however, tre... | The prevalence and case fatality of ehrlichiosis were 6.9% and 47.1%, respectively. Dogs in rural areas had 5.8 times higher odds of ehrlichiosis (odd ratio, OR: 5.84; 95% CI: 1.72-19.89) compared to urban areas. Dogs with access to other dogs had 5.14 times higher odds of ehrlichiosis (OR: 5.14; 95% CI: 1.63-16.27) th... | A sample of veterinarians from the US, UK, and Australia that prescribe fluralaner recommend that dog owners obtain approximately 12 months of flea protection per year and 9-12 months of tick protection per year. A variable proportion of owners (22%-90%) reported that their dog participates in outdoor and social activi... | Pastes with mechanically modified ivermectin showed 91.4-100% efficacy against strongyles and <i>Parascaris</i>. Pastes with modified albendazole and niclosamide were also effective against <i>Anoplocephala</i> in all tested dosages i.e. 78.6-100%. In particular, treatment with two formulations containing i) 0.2 mg ive... | This case provides the first evidence of canine acute local hypersensitivity reaction to mosquito bites under laboratory conditions. This observation suggests that invasive mosquito species such as Aedes spp. may affect the health and comfort of our companion animals, especially for pets with outdoor access without ind... | 42045933 | Parasites & vectors | [
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0.556829571723938,
0.6187694668769836,
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] |
Title: Diet-induced metabolic and faecal microbiome responses in pet dogs fed a minimally processed versus extruded kibble diet. Background: The extent to which food is processed influences gut functions, such as digestion, nutrient uptake, and microbiome response, with the potential to impact immuno-metabolic health. ... | The experimental diets resulted in distinct physiological and gut microbiome responses. MPD was associated with improved faecal consistency (FCS 2.24 ± 0.67, <i>p</i> = 0.005), lower pre- and post-prandial gastric inhibitory polypeptide (GIP, p < 0.001) and peptide YY (PYY, <i>p</i> < 0.05), and reduced post-prandial g... | Twenty-three dogs (31%) achieved sustained remission without documentation of relapse for at least 2 years. Nineteen dogs (25%) achieved remission, but then subsequently relapsed within 2 years of histopathologic diagnosis, and 33 dogs (44%) never achieved remission with disease-associated death occurring a median of 1... | In cats, no abnormal values were observed in complete blood count or blood chemistry tests, whereas significant decreases in blood glucose and total cholesterol were confirmed (<i>p</i> < 0.05 each). In the feline lymphocyte subset test, significant increases were observed in T and B cells (<i>p</i> < 0.05). A signific... | 76 Labrador Retriever puppies were recruited via Dogslife, a UK-based online cohort study. Faecal samples were collected at three to four, seven, and 12 months of age and analysed using 16 S rRNA gene sequencing alongside questionnaire data. Alpha and beta diversity were assessed using linear mixed effects models and p... | In plasma, Pulse45 had ∼32% greater postprandial Asn than Pulse15, and the control diet had ∼34% greater postprandial Leu and ∼35% greater Pro than Pulse15 (P < 0.05). In whole blood, Pulse30 had ∼23% greater postprandial Lys than the control diet, and the control diet had ∼21% greater postprandial Met and ∼18% greater... | Median CCECAI before FMT was 8 (range, 5-14), decreased to a median of 3 (range, 1-12) within 1 week and a median of 1 (range, 0-12) by Day 30 (P < .01), with an average duration of response of approximately 10 weeks. Significant variation in the donors' microbiota composition was observed across different donations. R... | 42038049 | Frontiers in veterinary science | [
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] |
Title: Comparative evaluation of trimethoprim-sulfonamide ratios and synergistic interactions against porcine respiratory pathogens. Background: Potentiated sulfonamides are widely used in the treatment of porcine respiratory disease complex, but their synergistic activity depends on pathogen-related and pharmacodynami... | The strongest and most consistent synergistic activity was observed at the 1:5 ratio across most pathogen-drug combinations. Increasing the proportion of the sulfonamide generally reduced synergism and occasionally resulted in antagonistic interactions, particularly in Glaesserella parasuis. Differences between sulfona... | GC-MS analysis of NHK-EO revealed three major constituents: carvacrol (16.37%), eugenol (15.04%), and linalool (13.97%). In total, 78 Gram-negative bacterial isolates were identified, with E. coli being the predominant species (56 isolates, 71.79%). Among these, four bla<sub>CTX-M</sub>-positive E. coli isolates (three... | No isolates from cats were susceptible to amoxicillin-clavulanate (susceptibility [S] ≤ 0.25/0.12) or amoxicillin (S ≤ 0.25); isolates from dogs had low susceptibility to amoxicillin 53% (S ≤ 8). Conversely, isolates from dogs had high susceptibility to amoxicillin-clavulanate 92% (S ≤ 8/4), despite equal 90th percenti... | The PK profiles and PK/PD relationship of orbifloxacin against <i>S. aureus</i> were investigated using a neutropenic murine thigh infection model with multiple dosing regimens. Orbifloxacin exhibited a short-duration post-antibiotic effect (PAE; 0.12–2.45 h) and a longer post-antibiotic sub-MIC effect (PA-SME; 2.13–5.... | In this study, 20 G. anatis strains were isolated from 191 clinical samples of pet birds, representing a prevalence of 10.5%. Isolates were identified by colony morphology, Gram staining, biochemical testing and PCR for the -intergenic spacer region of 16-23 S rRNA, which yielded diagnostic amplicons of 790 bp and 1080... | Of 56 canine urolithiasis, bacteria were isolated from uroliths of 38 canines (27 MAP and 11 non-MAP) but not from uroliths of 18 canines (5 MAP and 13 non-MAP). The most common bacteria found in nidus of MAP uroliths was <i>Staphylococcus pseudintermedius</i> (approximately 51%). An antimicrobial resistance was freque... | 42038042 | Frontiers in veterinary science | [
0.6379042863845825,
0.4464094638824463,
0.45094984769821167,
0.48870745301246643,
0.45559367537498474,
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] |
Title: Omeprazole as a Novel Treatment Option for Giardiasis in Cats. Background: Giardiasis is a common protozoal infection in cats, often treated with nitroimidazole derivatives such as metronidazole and secnidazole. However, there are concerns about resistance to nitroimidazoles and their adverse effects. Recent in ... | By day 7, faecal cyst positivity was 50% in both the omeprazole and metronidazole groups, 58.3% in the secnidazole group, and 83.3% in the placebo group. The reduction observed in the omeprazole and metronidazole groups was statistically significant compared with the placebo (p < 0.05). By day 14, cyst positivity furth... | Nine cats that were finally treated with phenobarbital (PB) monotherapy reached the primary goal (the seizure frequency after the treatment intervention was less than one seizure every 3 months). Three cats were treated with ZNS monotherapy and two reached the primary goal. Eight cats finally received combination thera... | Prescription data for 5724 visits were identified. Sporadic cystitis was the most common diagnosis (n = 5051 [88%]), with 491 (8.6%) cats diagnosed with pyelonephritis and 182 (3.2%) with chronic or recurrent cystitis. Cefovecin was the most commonly prescribed antimicrobial for all conditions, followed by amoxicillin-... | From the study cohort of 237 825 male cats, there were 1293 incident cases. The estimated UO incidence risk during 2016 was 0.54 (95% CI: 0.51-0.57). Demographic and clinical data were available for 1108 cases. Antibiotics were administered to 641/1108 (57.9%) cases. Overall repeat catheterization rate was 253/854 (29.... | Giardia cysts were not detected by microscopy in 16 out of the 50 samples (32%) of group A and in none of group B samples. Eight out of 50 samples in group B (16%) were tested positive both with the ProSpecT<sup>TM</sup> Giardia Microplate Assay and PCR. Fecal examination with the Speed<sup>TM</sup> Giardia test was mo... | No isolates from cats were susceptible to amoxicillin-clavulanate (susceptibility [S] ≤ 0.25/0.12) or amoxicillin (S ≤ 0.25); isolates from dogs had low susceptibility to amoxicillin 53% (S ≤ 8). Conversely, isolates from dogs had high susceptibility to amoxicillin-clavulanate 92% (S ≤ 8/4), despite equal 90th percenti... | 42035445 | Veterinary medicine and science | [
0.7623467445373535,
0.5514296293258667,
0.5038002729415894,
0.5190720558166504,
0.5153796076774597,
0.515242338180542
] |
Title: Case Report: Partial neurectomy and limb-sparing treatment for SOX-10 expressing epithelioid malignant nerve sheath tumour of the tibial nerve. Background: Epithelioid-variant malignant peripheral nerve sheath tumours (EMPNST) are rare in veterinary medicine and typically have poor outcomes. Limb-sparing partial... | This case demonstrates an atypical anatomical and histopathological presentation of canine EMPNST and shows that complete limb-sparing partial neurectomy can achieve long-term remission without compromising limb function. | Fourteen dogs with 16 tumors were included, of which nine tumors were treated for gross disease whilst seven tumors were treated post-surgery for microscopic residual disease. Four treatment sites treated with 35 Gy had ulceration post irradiation, which was graded as severe adverse effect. Only mild adverse effects we... | In at least one of the multivariable models, tumour grade (cutaneous Kiupel low or high grade) or tumour subcutaneous location, multiple concurrent MCTs, metastasis at the time of surgery, and senior age were statistically significant in predicting the outcome (MCT-related death and/or second MCT diagnosis) at 6- or 12... | To date, no clinical cases of canine spinal cord primary nephroblastoma that survived for 11 years after surgery have been reported. This case strongly suggests that providing intensive treatment for canine spinal nephroblastoma is very important. | Macroscopic and microscopic examination revealed progressive separation of the paratenon, peritendinous nerves, and fascicles, correlating with increased treatment duration. Fascicle penetration depths were 0.1 mm, 2.57 mm, 2.61 mm, and 3.93 mm at 1, 3, 5, and 7 min, respectively. ANOVA confirmed significant difference... | We provided evidence of OS innervation within and surrounding the tumour in association with mesenchymal stroma that also corresponded to the most proliferative area of the tumour (Ki-67+). In vitro, both MSC and, to a lesser extent, OS cells promoted axonal growth through cytokine (IL-6) and neuromodulator (BDNF) secr... | 42027815 | Frontiers in veterinary science | [
0.5728201270103455,
0.36395329236984253,
0.3556596338748932,
0.36673393845558167,
0.38130971789360046,
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] |
Title: Detrimental Effect of Low-Magnitude High-Frequency Vibration in an Ex Vivo Model of Intervertebral Disc Degeneration Despite Estrogen Treatment. Background: Postmenopausal females are at increased risk of intervertebral disc (IVD) degeneration due to estrogen decline. While both estrogen supplementation and low-... | PP digestion reduced cell viability and decreased GAG content, while increasing IL-6 and MMP-3 production. Treatment with E2 partially restored <i>ESR1</i> expression but did not affect cell viability or matrix metabolism. LMHFV (PP + LMHFV group) significantly increased DNA and GAG content compared with PP alone, wher... | All materials demonstrated excellent biocompatibility and osteoconductivity. At 3 months, Bio-Oss and Apaceram-AX exhibited significantly greater volumes of formation than the other materials, with Bio-Oss having a marginally higher amount. However, this outcome was reversed at 6 months, with no significant difference ... | On day 21 of the experiment, body weight, ovarian parameters (Ovarian weight, uterine weight, the number of ovarian follicles, and corpora lutea (CL) were determined, and histopathological changes, blood profile, as well as antioxidant activity assessment, were performed. CP significantly suppresses ovarian and uterine... | During the anestrus phase (control group C1), the progesterone concentration was minimal (1.53 ± 0.07 nmol/l). Progesterone levels showed significant variation across different phases of the estrous cycle, measuring 4.56 ± 0.20 nmol/l (<i>p</i> < 0.001) in proestrus, 19.54 ± 0.17 nmol/l in estrus (<i>p</i> < 0.001), an... | Chondrogenic and osteogenic differentiation performance of equine BM- and AT-MSCs declined with increasing donor age. BM-MSCs had a higher chondrogenic differentiation performance. AT-MSCs showed minimal chondrogenic differentiation performance in all age groups. For osteogenesis, alkaline phosphatase activity was also... | Results showed a significant increase in the synaptic density profile of the hippocampal CA1 region in both the early estrogen (0.534 ± 0.026 µ/m<sup>2</sup>) and the early raloxifene (0.437 ± 0.012 µ/m<sup>2</sup>) treatment groups compared to the early or late vehicle-treated control groups (0.338 ± 0.038 µ/m<sup>2</... | 42027793 | JOR spine | [
0.5170291066169739,
0.4189012050628662,
0.39376869797706604,
0.3694036304950714,
0.3790048360824585,
0.4113277792930603
] |
Title: Investigation of the clinical efficacy of mesenchymal stem cells in combination with monoclonal antibody therapy against feline panleukopenia. Background: Feline panleukopenia is an acute and highly contagious disease caused by feline panleukopenia virus (FPV). Conventional therapeutic approaches often yield sub... | The results revealed that in the control group and conventional treatment group, cats exhibited a rapid decline in white blood cell count following disease onset, ultimately resulting in mortality. Conversely, in the MSCs group, four cats demonstrated an increase in white blood cell count post-treatment, subsequently r... | Follow-up data were available from 18 cats in week 24, from 15 cats in week 36 and from 14 cats in week 48 (after the start of treatment), respectively. Laboratory parameters remained stable after the end of the treatment, with undetectable blood viral loads (in all but one cat on one occasion). Recurrence of faecal FC... | Eight of the 10 cats treated with MPV survived and were in remission at 16 weeks. The 2 non-survivors died in the first 24 hours of treatment. No adverse events that necessitated discontinuation of treatment were observed. Survival of cats treated with PO MPV was non-inferior to historic control cats treated with PO GS... | Records for 153 cats (154 eyes) were included. Median age in the treatment success group was 8 years (interquartile range (IQR) 4-12), with a median ulcer depth of 30% (IQR 30-40). Median age in the treatment failure group was 10.5 years (IQR 4.75-12) with a median ulcer depth of 45.9% (IQR 30-75). Persian cats were th... | Cats received treatment with different combinations of IV remdesivir, SC remdesivir, and PO GS-441524 at a median (range) dosage of 15 (10-20) mg/kg. Clinical response to treatment was observed in 28 of 32 cats (87.5%) in a median (range) of 2 (1-5) days. Twenty-six of 32 cats (81.3%) were alive and in clinical and bio... | This case suggests that localized MRSP skin infections in selected feline patients receiving immunosuppressive therapy may be successfully managed with topical-based management alone. Such an approach supports antimicrobial stewardship in veterinary medicine, highlighting that topical therapy may be considered a reason... | 42026664 | Stem cell research & therapy | [
0.5971640348434448,
0.4494834840297699,
0.44238731265068054,
0.46364185214042664,
0.43503129482269287,
0.43614670634269714
] |
Title: Impact of different levels of diastema and crowding on the precision of 3D-printed dental models: a comparative analysis using digital superimposition. Background: This study aimed to evaluate the impact of varying degrees of anterior diastema and crowding on the precision of 3D-printed dental models using digit... | Significant differences were observed among diastema groups (p < 0.05), with the 5 mm group showing the widest deviation range. RMS and average deviation values were highest in the 2.5 mm and 5 mm diastema conditions. In the crowding groups, significant deviations in minimum and maximum values occurred only in the 12 m... | The mandibular inter-canine width accuracy was statistically significant between groups (p = 0.050). Significant under-correction in horizontal movements was noted for mandibular first premolars in teenagers compared to adults (p = 0.037). There was considerable over-correction in horizontal movements for mandibular ce... | We illustrate multiple benefits and indications for 3D printing in veterinary oral and maxillofacial surgery. 3D printed models facilitate the understanding of complex surgical anatomy, creating an opportunity to assess the spatial relationship of the relevant structures. It facilitates individualized surgical planning... | Statistically significant results were found for all the groups investigated. All three groups preferred the photo that maintained the typical symmetrical 'high-low-high gingival contour. Moreover, both orthodontic specialists and general dentists preferred unilateral mesialization of the canine and conservative rehabi... | 1xP generated intermediate mean surface loss, positioned between the values observed for passive control (PC) and active control (AC), and those for 2xP and 3xP. Losses from active applications were significantly higher than passive ones and were increased by the number of applications. SEM showed Types II and III etch... | Managing caries is imperative in a rapidly aging society. Current diagnoses use qualitative indices. However, a quantitative evaluation of hardness in a clinical setting may lead to more accurate diagnoses. Previously, hardness meter using indenter with light for tooth monitoring (HAMILTOM) was developed to quantitativ... | 42018816 | Dental press journal of orthodontics | [
0.8284642100334167,
0.47953200340270996,
0.44624897837638855,
0.44560331106185913,
0.4654552936553955,
0.46662721037864685
] |
Title: Surgical Management of a Left Main Coronary Trunk-Adjacent Functional Cardiac Paraganglioma Using Proactive Coronary Artery Bypass Grafting: A Case Report. Background: Cardiac paragangliomas are exceptionally rare and often functional tumors that frequently arise near the aortic root and proximal coronary arteri... | For functional cardiac paragangliomas adjacent to the LMT, integrating planned revascularization before tumor manipulation can provide a myocardial "safety net" that enables oncologically oriented en bloc resection when coronary sacrifice becomes unavoidable. This operation carries an exceptionally high risk of massive... | A pattern of left coronary dominance was identified in the observed sample, with subtype II being the most prevalent in 25 (83.3%) hearts and subtype III in only 5 (16.7%) cases. The right coronary artery terminated between the right margin and the cardiac cross in 25 (83.3%) patients. The left coronary artery had a hi... | Anomalous origin of the left coronary artery from the pulmonary artery is overlooked in clinical practice due to its rarity. Coronary computed tomographic angiography was useful to definitively diagnose ALCAPA in a low-invasive manner. Antemortem diagnosis of ALCAPA was shown to be possible in dogs for the first time, ... | In terms of IVC management, 5 cases had conventional total occlusion of the IVC and its branches, 3 cases had delayed occlusion of the proximal IVC technique, 2 cases had IVC resection by Satinsky clamp, 5 cases had IVC ligation, 1 case had IVC reconstruction by bovine pericardial grafts and 1 case had IVC transection ... | Usability testing of all TPP devices was successful (n = 20;100%, delivery-time range 22-120 s) without any procedural adverse-events (tissue damage or tears, bleeding, vessel-impingement, structural impact). All devices fully traversed the ostium (n = 18) or appendage body (n = 2), and conformed smoothly to adjacent c... | This is an unusual case as it features numerous congenital abnormalities that appeared to negate each other allowing capability with life. To the authors' knowledge, this collection of concurrent cardiac anomalies has not been previously reported in bovines. | 42016547 | Surgical case reports | [
0.7094100117683411,
0.3577578067779541,
0.37975990772247314,
0.3201448321342468,
0.31157371401786804,
0.3475745618343353
] |
Title: Clinical outcomes and association with disease progression and survival of subclinical bacteriuria in cats with chronic kidney disease: a multicenter retrospective study. Background: Subclinical bacteriuria (SBU) is frequently encountered in cats with chronic kidney disease (CKD), but it remains unclear if it is... | SBU was not significantly associated with survival (hazard ratio [HR] = 0.68; 95% CI, 0.39-1.16; P = .16) or CKD progression (P = .84). Higher plasma creatinine (HR = 1.02; 95% CI, 1.00-1.03; P = .01) and lower body condition score (HR = 0.80; 95% CI, 0.67-0.95; P = .01) were associated with reduced survival. In SBU ca... | The study population consisted of 365 dogs and 515 cats to give a total of 880 patients hospitalised at the IDIU from October 2013 to December 2018. Among the 96 referred dogs, parvovirosis (37.7%) and leptospirosis (31.1%) were the most frequent IDs. Feline upper respiratory tract infection (38.2%) and feline leukaemi... | This study has been designed to mirror current standards of clinical management; conclusions should therefore, be widely applicable and guide practising veterinarians in their antimicrobial decision-making process. A duration-response curve will be created allowing determination of the optimal treatment duration for th... | The overall response rate was 74% (n = 23), with 45% (n = 14) achieving complete remission (CR), 29% (n = 9) achieving partial remission (PR) and 26% (n = 8) achieving stable disease (SD). The Kaplan-Meier median PFI and MST were 139 days and 206 days, respectively. Responders (CR or PR) had a significantly longer (<i>... | The cat did not receive any further treatment for both FIP and lymphoma. Still alive and well, almost 5 years after the diagnosis. To the author's knowledge, this is the first case of renal lymphoma in a cat that subsequently developed FIP. Further studies on the potential correlation between lymphoma, chemotherapy, an... | A total of 56 cats were included in this study; 38 cats had a DFB and 18 had an LFB. No cats developed postoperative septic peritonitis, and all cats survived. The likelihood of postoperative septic peritonitis or mortality in an additional cat was estimated to be <5.2%. Cats with an LFB were found to have a significan... | 42012812 | Journal of veterinary internal medicine | [
0.7852823734283447,
0.5349829792976379,
0.5358315110206604,
0.5268142819404602,
0.5689302682876587,
0.551722526550293
] |
Title: The Effect of Orthodontic Tooth Movement on Intrabony Periodontal Defects After Guided Tissue Regeneration-Part I: Human Histologic Evaluation of 20 Consecutive Cases. Background: To histologically evaluate the healing of intrabony periodontal defects treated with guided tissue regeneration (GTR), if it is combi... | Control group cases (n = 9) revealed nice embedding of graft particles into newly formed bone, which were predominantly present in the central and apical third of the biopsy samples. The coronally located DBBM was more often encapsulated in the connective tissue. Test samples (n = 10), both at the tension and pressure ... | These results suggest that surgically assisted and implant anchored-orthodontic approaches might be effective for the correction of such malocclusions. | Nearly complete root coverage was achieved, with recession depth reduced to 1 mm and keratinized tissue width increased from 1 mm to 6 mm. Ultrasound imaging confirmed successful graft integration and thick gingiva. At 2-year follow-up, creeping attachment was observed after the patient discontinued the self-injurious ... | No statistically significant difference was found between the RG and NRG groups in terms of lateral incisors. In both groups, there was a statistically significant decrease in lateral incisor volume, mesiodistal and buccolingual root width, and crown-root angle on the impacted side compared to the other side. In the RG... | Histometric evaluations confirmed higher levels of new bone formation in the 3D-printed membrane group. Moreover, in all defects treated with the membranes, the formation of periodontal tissues, bone, periodontal ligaments, and cementum was observed after 8 weeks, while in the control group, only connective tissue was ... | The extraction of canines and substitution by first premolars could be a feasible orthodontic treatment. | 42009610 | Journal of clinical periodontology | [
0.6558838486671448,
0.5566661357879639,
0.575859010219574,
0.5504815578460693,
0.5477558970451355,
0.5309948921203613
] |
Title: Pepsin-induced Differential IL-6 Expression in Laryngeal and Laryngopharyngeal Tissue: Non-invasive Rat Model for Laryngopharyngeal Reflux. Background: Laryngopharyngeal reflux is a common condition caused by exposure of the upper aerodigestive tract to gastroduodenal content, resulting in inflammation to the ar... | Significant differences in laryngeal and laryngopharyngeal tissue IL-6 concentration were measured (p = 0.005 and p = 0.020 respectively). Laryngeal expression of IL-6 was related to the volume administered (p = 0.007) but not to the duration of exposure (p = 0.338), with no significant interaction between duration of ... | Negative effects on cell viability were not observed when REC were exposed to 10 μM CBD. However, when the dose was increased to 50 μM for 24 h, there was a significant cytotoxic effect. When 10 μM CBD was added to culture media as treatment for inflammation induced with lipopolysaccharide (LPS), expression of genes en... | The results of Experiment 1 showed that administration of ATC improved growth performance and antioxidant functions in the serum and the liver, as well as immunoglobulin A, G, and M levels in rat serum, and it decreased the content of alanine aminotransferase, aspartate aminotransferase, triglyceride, cholesterol, low-... | The DGGR lipase activity was increased >3× the upper reference limit at admission in 216/1360 (16%) dogs, of which 70/216 (32%) had a clinical diagnosis of AP. Other primary conditions associated with hyperlipasemia were renal, endocrine, and immune-mediated diseases, and upper airway obstruction. Predictors of hyperli... | Mucosal calprotectin concentrations in dogs with CIE were significantly higher in the duodenum (median: 276.2 μg/g) and colon (median: 298.2 μg/g) compared to healthy controls (median: 94.3 μg/g, P = 0.0039; and median: 112.0 μg/g, P = 0.0061). Similar numerical differences in the ileum and cecum were not statistically... | In vitro assays revealed pretreatment with L. casei 03 reduced the apoptotic ratio and the mRNA expression levels of IL1β, IL6 and TNFα and suppressed phosphorylation of p65, IκBα, p38, JNK and ERK in the NF-κB signaling pathway and MAPK signaling pathway. Furthermore, in vivo tests indicated that intramammary infusion... | 42006898 | Iranian journal of otorhinolaryngology | [
0.8270882964134216,
0.38244473934173584,
0.3633626103401184,
0.3460194170475006,
0.34634825587272644,
0.33878687024116516
] |
Title: Serum untargeted metabolomics reveals key pathways in feline mammary carcinoma for comparative oncology. Background: The development of breast cancer exhibits a heterogeneous and complex character in both felines and humans, which motivates the search for serum biomarkers for diagnosis, prognosis, and therapeuti... | Twenty-six metabolites or chemical classes were found significantly altered. The main alteration was related to the metabolism of amino acids, carbohydrates, and the tricarboxylic acid cycle, mostly with reduced serum levels in female cancer patients, suggesting high tumor uptake. Analysis of metabolic pathways reveale... | The short-term mortality rate was 12.0% (95% confidence interval [CI], 6.6%-19.7%). Univariate analysis identified plasma lactate dehydrogenase activity (LDH; P < .001) and bilirubin concentration (P = .001) as being significantly increased in nonsurvivors, whereas concentrations of albumin (P = .003), total protein (P... | 452 unique serum miRNAs were detected by RNAseq. Sixty-five individual miRNAs were differentially expressed (>±1.5-fold) and statistically significant between groups. Serum miR-19b (P = .003) and miR-125a (P < .001) were significantly higher in the mammary carcinoma group by dPCR. Both had high accuracy based on receiv... | The PL-MN and PL-NMN median concentrations of the healthy cats were 2.73 and 7.02 nmol/L, respectively. The median U-MN/Creat and U-NMN/Creat ratios were 70 and 139 μg/g, respectively. The PheoCat had a PL-MN of 3.68 nmol/L, PL-NMN of 66.27 nmol/L, U-MN/Creat of 179 μg/g, and U-NMN/Creat of 1262 μg/g. The PheoCat had m... | The literature findings suggest that canine spontaneous tumors are valuable model systems with important translational implications for identifying novel mechanisms of chemotherapy resistance shared with humans and may help advance the current standard of care in precision medicine. We have provided an updated overview... | Side effects were limited to local inflammation in three cats. Three cats developed local tumor recurrence at days 180, 180, and 545 after surgery, two cats developed recurrence and metastases at 100 and 505 days after surgery, and two cats experienced distant metastases. A median time to recurrence could not be calcul... | 41998452 | Metabolomics : Official journal of the Metabolomic Society | [
0.6679051518440247,
0.45130762457847595,
0.4999656677246094,
0.480307936668396,
0.44325536489486694,
0.4576173722743988
] |
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