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Title: Canine Tooth Microbiome Gingival Index: a new microbiome-derived measure of gingival health validated by nutritional intervention. Background: Periodontitis affects over 80% of dogs over 3 years of age, progressing irreversibly from gingivitis due to an imbalance in the subgingival microbial community that trigg... | The two top-performing models-random forest and logistic regression-yielded 22 unique features. These 22 features included the sum of early and late colonizers, the phyla actinobacteria and proteobacteria, and other bacterial species. The CTMGI was derived from the 22 features, categorized as "positive" or "negative" b... | FMDV infection in oral mucosal epithelial swabs (ct = 28.9), saliva (ct = 30.62), and blood plasma (ct = 37.17) compared to controls used from the Farma Veterinary Center (ct = 29.10) using RT PCR (3D gene). These results indicate that the sensitivity value of oral mucosal epithelial swab specimens is the same as posit... | The study included a random sample of 22,333 dogs. The 1-year period prevalence for diagnosis with periodontal disease was 12.52% (95% CI: 12.09 to 12.97). Eighteen breeds showed increased odds compared with crossbred dogs. Breeds with the highest odds included Toy Poodle (odds ratio 3.97, 95% confidence intervals 2.21... | IMHA/ITP is associated with remodeling of fecal microbiota, marked by decreased relative abundance of the spirochete Treponema spp., increased relative abundance of the pathobionts Clostridium septicum and Escherichia coli, and increased overall microbial diversity. Logistic regression analysis demonstrated that Trepon... | The overall response rate was 14.7%, with a best overall response rate of 16.7%. Treatment-related adverse events occurred in 40.0% of the dogs, which were primarily grade 1-3. Increased baseline white blood cell, neutrophil count, and C reactive protein levels were significantly associated with poor response, shorter ... | The analysis included a random sample of 1,835 confirmed incident acute diarrhoea cases in 2019 from an overall study population of 2,250,417 dogs. After accounting for subsampling, the estimated one-year incidence risk for acute diarrhoea in dogs overall was 8.18% (95% CI: 7.83-8.55). Of the first acute diarrhoea even... | 42328069 | Frontiers in veterinary science | [
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Title: Evaluating the synergistic effects of cisplatin and tamoxifen in canine osteosarcoma cells. Background: Canine osteosarcoma is an aggressive primary bone tumor with a high metastatic rate and poor long-term prognosis. Therapeutic resistance remains a major cause of treatment failure. In human osteosarcoma, sex h... | Synergy analysis at 24 hours demonstrated strong synergistic activity between tamoxifen and cisplatin, with a ZIP score of 16.82. Combination treatment reduced metabolic activity and activated apoptotic markers at lower drug concentrations compared with either treatment alone. Although estrogen receptor expression was ... | Eleven dogs were enrolled in this prospective study. High grade adverse effects were common, especially if bone was included in the treatment field. Four out of six dogs, who had bone in their treatment field and lived at least 5 months after RT, developed osteoradionecrosis at 3-12 months post treatment. The treatment... | The dose determination study showed the systemic administration of ePB-MSCs in a canine OA model resulted in an analgesic, anti-inflammatory, and joint tissue protective effect associated with improved clinical signs and improved cartilage structure, as well as a good safety profile. Furthermore, a clear dose effect wa... | A single TT treatment resulted in 75% complete response (CR) (95% confidence interval [CI] = 61-86) by 28 days, with no recurrence in 93% (95% CI = 82-97) of dogs by 84 days. Eight TT-treated dogs that did not achieve CR in phase 1 achieved CR after retreatment, increasing the overall CR to 88% (95% CI = 77-93). Contro... | SOD treatment resulted in anti-proliferative effects and mediated cell cycle arrest in the canine mammary gland tumour cell lines (CIPp and CIPm). It also downregulated the expression of N-cadherin and Vimentin. The results confirmed that SOD inhibits tumour cell proliferation and migration, thus supporting the potenti... | Cannabidiol reduced cell viability and induced apoptosis in canine urothelial cells as determined by crystal violet viability assay and annexin V/propidium iodide flow cytometry. Furthermore, combinations of cannabidiol with mitoxantrone and vinblastine chemotherapy yielded significantly reduced cell viability and incr... | 42328057 | Frontiers in veterinary science | [
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Title: First molecular detection of <i>Theileria haneyi</i> infection in horses in Southern Spain. Background: Equine piroplasmosis (EP) is a tick-borne disease of equids caused by the hemoparasites <i>Theileria equi, Babesia caballi</i>, and <i>Theileria haneyi</i>. <i>T. haneyi</i>, a close relative of <i>T. equi</i>... | Three horses out of 222 (3/222; 1.35%) were positive for <i>T. haneyi</i>. These three positive horses were located in Southern Spain in the provinces of Huelva, Cadiz, and Malaga. Additionally, 76 (76/222; 34.2%) were positive for <i>T. equi</i>. All three <i>T. haneyi</i>-positive horses were also found PCR-positive ... | Despite the circulation of zoonotic tick-borne pathogens among livestock and tick vectors, human infections have been overlooked and are potentially limited to infer the actual communicable disease burden. Therefore, facility-based surveillance of TBDs, combined with capacity building for laboratory diagnostics in heal... | Clinical examination revealed non-painful, nonpruritic growths ranging in diameter from 2 to 8 mm. Histopathological analysis of skin biopsies showed thickening and hyperplasia of all epidermal layers, accompanied by acanthosis, hyperkeratosis, and the presence of koilocyte within the stratum spinosum and granulosum. M... | In our study, Taylorella equigenitalis was found infrequently (53 out of 25,512 samples), representing 11 out of 2308 stallions. If T. equigenitalis was detected, the stallions were treated with antibiotics and re-tested later in the same year. Klebsiella pneumoniae and beta haemolytic streptococci were the most common... | All horses exhibited acute signs of neurologic disease including ataxia and proprioceptive deficits. Horses tested positive for TBEV using virus neutralization test and samples were further tested for TBEV-specific IgM. The presence of TBEV-specific IgM antibodies was confirmed in 5 horses (cases 1-5, Laboratory Unit [... | Collectively, the SNAP<sup>®</sup> 4Dx<sup>®</sup> Plus Test provided 64% seropositive results, comprising Ehrlichia species (59%), Anaplasma species (45%), Dirofilaria immitis (2%), and Borrelia burgdorferi (< 1%). Altogether, prevalence as determined by probe-based qPCR assays was 54%, comprising Ehrlichia canis (27%... | 42328053 | Frontiers in veterinary science | [
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Title: Assessment of Ocular Surface Pathogen Susceptibility to Ultraviolet-C (UVC) Light Treatment With a Novel Prototype Device-An In Vitro Study. Background: Assess in vitro efficacy of a device emitting 265 nm UVC light against bacteria isolated from veterinary infectious keratitis. | UVC inhibition was complete in 11/30 isolates at ≤ 5 s exposure. Partial efficacy was seen in 18/19 remaining isolates at 5 s; ≥ 33% zones demonstrated absence of bacterial growth. Efficacy against MDR-MRSP and MDR-E. coli was comparable to susceptible counterparts. All P. aeruginosa were completely inhibited at ≤ 5 s;... | The mean (SD) tear film osmolality was 283.51 (9.33) mmol/kg, and the mean (SD) sodium, potassium, magnesium and calcium concentrations were 134.75 (10), 16.3 (5.77), 3.48 (1.97) and 1.06 (0.42) mmol/L, respectively. The sodium concentration in the tear film was similar to that in serum, whereas the potassium concentra... | We have developed a feasible method for photodynamic antibacterial therapy, possessing excellent biocompatibility and high antibacterial efficiency with good fluorescence imaging property. | IMMK subtype was classified as 10/94 (10.6%) epithelial, 50/94 (53.2%) anterior stromal, 14/94 (14.9%) mid-stromal, 4/94 (4.25%) endothelial and 16/94 (17.0%) unrecorded. After excluding three horses with incidental corneal ulceration, blepharospasm was documented in 34/91 (37.4%), corneal ulceration in 26/91 (28.6%), ... | We developed a rapid assay (RPAS) combining RPA with SYBR Green I for the detection of BVDV. The BVDV RPAS assay was performed at 37 °C in 25 min. The minimum detection limit of the RPAS assay is 1 × 10<sup>9</sup> copies/µL in sunlight and 1 × 10<sup>5</sup> copies/µL in ultraviolet light, and there is no cross-reacti... | The statements covering the following topics were analyzed in this paper: (i) Understanding photobiomodulation via FLE; (ii) Indications and Protocols for FLE; and (iii) FLE pet owner information. Consensus was reached on 33 out of 33 statements (100%) addressing the use of photobiomodulation via FLE; the practical mod... | 42321970 | Veterinary ophthalmology | [
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Title: Granulosa Cell Tumour in a Spayed Cat With Ovarian Remnant Syndrome and Hyperestrogenaemia Without Estrus Signs. Background: Granulosa cell tumour (GCT) is the most common primary ovarian neoplasm in cats and may arise from residual ovarian tissue following incomplete spay procedures. To describe the surgical ma... | Histopathology confirmed GCT in the abdominal mass with hepatic metastasis. A preoperative serum sample collected at initial presentation and assayed after receipt of the histopathology report showed markedly increased estradiol. Although clinical signs improved after surgery, the cat re-presented 4 weeks later with ab... | Fourteen dogs with 16 tumors were included, of which nine tumors were treated for gross disease whilst seven tumors were treated post-surgery for microscopic residual disease. Four treatment sites treated with 35 Gy had ulceration post irradiation, which was graded as severe adverse effect. Only mild adverse effects we... | A total of 64 cases of canine TVT were diagnosed. 52 dogs were cross-breed (81.2%) while 4 Siberian Huskies (6.2%) and 3 German shepherds (4.7%) were the most affected pure-breed dogs. The median age of dogs at diagnosis was 3 years (range, 1-10years) and male gender was more common (male:female ratio; 1.3:1). Tumor wa... | The largest group were canine tumours, of which there were 9,745 (85.95%), followed by feline tumours, totalling 1,397 (12.32%), tumours from exotic animals (186; 1.64%), from horses (7; 0.06%), and from cows (2; 0.02%). A significant number of cases of animals suffering from more than one tumour were also found, which... | This case illustrates a granulomatous interstitial polymyositis and intramuscular neuritis that improved clinically and resolved histologically with glucocorticoid treatment. Idiopathic granulomatous myositis and neuritis should be considered as a differential diagnosis in dogs with clinical signs of neuromuscular diso... | Twenty-nine tumors were classified as luminal and 27 tumors as basal subtype. Basal tumors were strongly associated with immune infiltration (OR 52.22, 95%CI 4.68-582.38, <i>P</i> = 0.001) and cancer progression signatures in RNA-seq analyses, more advanced clinical stage, and earlier onset of distant metastases in exp... | 42319189 | Veterinary medicine and science | [
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] |
Title: 'Helpful', 'Objective', and 'Useful': User Perceptions of the Animal Welfare Assessment Grid (AWAG) for Dogs as a Decision-Making Tool. Background: Ethical decision-making in veterinary practice and in animal welfare sectors can be particularly challenging. Decision-making is reported to be largely subjective wi... | Over 96% of respondents acknowledge the utility of the AWAG in aiding in decision-making and it is reported to facilitate discussions among colleagues and dog caregivers about welfare. While the overall sentiment towards the AWAG was predominantly positive, a minority of users expressed difficulties in using the tool, ... | A total of 208 registered veterinarians participated in this study. The study involved a majority of male participants, constituting 85.1%, while 54.8% of the participants held a Masters degree. Around 52% of the veterinarians were poultry practitioners. All respondents were familiar with antimicrobials. The participan... | Based on interview findings, ten items were reworded, four removed, and two added; resulting in 26 items that all owners understood and considered relevant. The recall period and response options were well understood and appropriate to almost all owners. To evaluate its psychometric properties, the CaOA-QoL-TS (draft 2... | Analysis revealed significant anxiety and fear associated with medication administration, with 12% of posts mentioning anxiety and additional fear-related terms appearing in 1-3% of posts. Only 7.6% of posts discussed soft/chewable medications, which showed positive sentiment and preference. Geographic analysis showed ... | A total of 15,725 records were submitted by the 14 participating pharmacies and 91 records were entered by the 15 participating farmers. Overall, the participants were positive about the system and were able to use it. The information available was appreciated by the farmers. The pharmacy representatives appreciated ge... | In cases n. 2, 3, 4, 5, 7 owners of dogs affected with CAD partial or full reimbursement from the seller obtained. In cases n. 9, 10, 11, 12, and 13, dog owners could not take any legal action because the diagnosis of CAD was made beyond the time limits required by law. In cases n. 1, 6, and 8, the owners decided not t... | 42319182 | Veterinary medicine and science | [
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Title: A non-trauma-focused equine-assisted intervention was associated with reductions in all four PTSD symptom clusters in treatment-resistant military veterans. Background: Veterans are at greater risk of developing post-traumatic stress disorder (PTSD) and show a poorer response to first-line treatments than civili... | A linear mixed model showed that scores for all four PTSD symptom clusters significantly improved over the course of the program. Cluster B (intrusion) and cluster C (avoidance) decreased even further after termination of the program at week 12, demonstrating additional long-term effects. Cluster D (negative changes in... | The multinomial logistic regression analysis found no statistically significant association between intervention (cHAT) and treatment outcome (completion, dropout, transferred) among the 37 participants who were ultimately recruited to the study. Some unforeseen challenges were encountered in the study: a high number o... | Twenty-four owners of 22 Addisonian dogs took part in four events. Owners felt most "traumatised" when experiencing their dog's acute adrenal crisis. The initial adjustment phase and distinguishing the non-specific symptoms of hypoadrenocorticism from those of other diseases were also challenging. Overall, owners were ... | Of the 27 acute and chronic wounds included in the analysis, 81.48% showed complete healing after the administration of CAMP as an adjunct therapy to standard care. Most wounds achieved complete healing in < 5 weeks. Compared with the pre-CAMP period, the rate of wound healing significantly increased every week in the ... | Fifty-five of 60 students (91.7%) that completed the questions on mistreatment indicated that they experienced and/or witnessed a mistreatment during veterinary education. 92% of students that experienced a mistreatment said that it interfered with the learning environment but only 29% of students reported the mistreat... | Interest in interventions such as neurofeedback, transcranial direct current stimulation, music therapy, equine-assisted therapy, virtual reality, and gamification has grown substantially. However, most of these approaches lack methodological standardization and robust evidence to justify their use as primary treatment... | 42317715 | Frontiers in psychology | [
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Title: Clinical and radiographic evaluation of manus and pes lesions, including the carpus and tarsus, and associated risk factors in dromedary camels <i>(Camelus dromedarius)</i>. Background: Injuries of the Manus and Pes, including the carpus and tarsus are a primary cause of lameness and subsequent economic loss in ... | Clinical and radiographic assessments identified 325 distinct lesions. Hard-tissue lesions (62.5%)-predominantly fractures, joint dislocations, and bony exostoses, were significantly more prevalent than soft-tissue lesions (37.5%), such as fibromas, flexural deformities, wounds, and penetrating solar nails. These condi... | The most frequently recorded lesions were digital dermatitis (32%), white line disease (21%), sole ulcer (19%) and sole haemorrhage (13%). White line disease had the highest percentage of lesions requiring veterinary attention and most frequently re-presented. Most lesions were in hind feet and there was a small but si... | This case report describes the clinical signs, diagnostic procedures and pathological findings in an adult female alpaca suffering from cranial nerve abnormalities caused by a massive otogenic brain abscess. Camelids suffering from otitis may not present with clinical signs until the pathology is severe. The importance... | Odds of survival were 3.9 times higher in camelids with a total nucleated cell count (TNCC) <3 cells/μL (P = .04). No significant association was found between survival and total protein concentration (TPC; P = .15) or percentage of eosinophils (P = 1.0). No significant correlation was found between species and increas... | Horses underwent one (n = 107), two (n = 19), or three (n = 2) surgeries. Survival to hospital discharge was 84.4%. Univariable survival analysis revealed that administration of systemic antimicrobials prior to referral was associated with reduced mortality (hazard ratio, [HR] 0.41, 95% CI 0.18-0.91, P = 0.03). Increas... | The clinical examination showed grade III-IV lateral PL. Radiologically, there were unilateral or bilateral, ventrocaudal, and dorsal PLs. Two cases were referred to surgical correction. One case almost restored the normal movement of stifle joint together with a good general status 1 year postsurgery. However, the sur... | 42317456 | Frontiers in veterinary science | [
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Title: Clinical factors, service type, and clinical outcomes associated with canine parvovirus in dogs presented at the KNUST Veterinary Teaching Hospital in Kumasi, Ghana. Background: Canine parvovirus (CPV) continues to be a predominant cause of morbidity and mortality among dogs worldwide. In Ghana, data on clinical... | A total of 129 CPV-positive dogs were diagnosed, with an overall mortality rate of 26.4% (34/129), compared to 8.5% (7/82) among CPV-negative dogs. Haemorrhagic diarrhoea (OR = 6.84), vomiting (OR = 2.75), lower body weight (OR = 0.94 per kg increase), and complete loss of appetite (OR = 4.29) were significant independ... | Fifty and 64 dogs were in ACVIM stage B1 and B2, respectively. The presence of LRTD was prevalent in 74.6% (85/114) of small-breed dogs with preclinical MMVD. When a previously reported criterion for CPE diagnosis (≥2 sites with >3 B-lines/site) was applied, false-positive results were observed in 15.8% (18/114) of dog... | The study included 23 CDV-infected dogs with neurological signs, 10 diseased but CDV-negative (non-infected) dogs, and 12 healthy controls. CSF samples were analyzed using Reverse Transcription Polymerase Chain Reaction (RT-PCR) for CDV sequences and the sandwich enzyme-linked immunosorbent assay (ELISA) method for qua... | From the study, it was found that the endoparasitic infestation was highly frequent in both dog and cat (55% in dogs and 59% in cats). The endoparasitic infestation was highly prevalent in cats (91.53%) significantly (<i>p</i> = 0.003), which were ≤1 year of age. On the other hand, the ectoparasitic infestation was fou... | Venous blood samples were collected from dogs without clinical signs (n = 30) and with clinical signs (n = 35) suggestive of Leishmania infantum infection. Among 65 samples examined, Leishmania DNA was detected by nested-PCR in 89.23% (58/65). Furthermore, 86.15% (56/65) nested-PCR positive samples were also DAT po... | Common examination findings in dogs with a presumed antemortem diagnosis included fever (21%) and heart murmur (19%). Median cardiac troponin I was 12.2 ng/mL (range: 0.2-808.0 ng/mL), and troponin exceeded 1.0 ng/mL in 26 of 29 (90%) dogs. Ventricular ectopy was the most common arrhythmia (54%), whereas decreased left... | 42316295 | Companion animal health and genetics | [
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] |
Title: Transcranial photobiomodulation therapy with 808 nm and 1064 nm can affect different behavior parameters in dogs. Background: To evaluate if transcranial photobiomodulation could improve behaviors in working dogs. | The animals in the sample had a mean age of 4.4 ± 2.0 years, with 24 males and 12 females. Three breeds were represented: Belgian Malinois Shepherd Dogs (n = 23), Dutch Shepherd Dog (n = 8), and German Shepherd Dogs (n = 5). Changes in the CFQ, L-CARS, and components were mainly driven by improvements in TG1064, with a... | In total, 138 dogs were presumptively diagnosed with MUO. The most common location for lesions identified on MRI were the white matter tracts of the corona radiata and corpus callosum, followed by the frontal, sensorimotor and temporal cortices. Lower T2 lesion load (<i>p</i> = 0.006, OR = 0.942, CI = 0.902-0.983) was ... | Breeds represented most often included the Golden Retriever (n = 12), Bernese Mountain Dog (10), Wirehaired Pointing Griffon (9), Boxer (9), and Beagle (6). No breed differences were identified with respect to clinical severity, diagnostic findings, or outcome. Twenty-nine dogs (48%) had ≥1 disease relapse. There was a... | While STT-1 showed no significant difference among dog groups, brachycephalic dogs had significantly lower values in TBUT, NIBUT, and LLT, and a higher TMH, compared to mesocephalic and dolichocephalic dogs. Additionally, brachycephalic dogs exhibited a significantly higher MGLRL than dolichocephalic dogs. Correlations... | The survey received a 35% response rate, for a total of 180 participant responses. Fewer than 50% of veterinary neurologists are currently performing EEG and it is performed infrequently. The most common indication was to determine a discrete event diagnosis. Other reasons included monitoring treatment, determining bra... | The DCE-MRI analysis of the piriform lobe identified higher BBBP score in the IE group when compared with controls (34.5% vs 26.5%; P = .02). Activity and expression of MMP9 were increased in the serum, CSF, and piriform lobe of IE dogs as compared with controls. Gene expression of Kir4.1 and claudin-5 in the piriform ... | 42315691 | Lasers in medical science | [
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] |
Title: Type 1 Collagen/Poly-L-Lactic Acid Biocomposite Augmentation of a Nontraumatic Symptomatic Complete Rotator Cuff Tear. Background: Treatment modalities for rotator cuff tears are continuously evolving. Augmentation of rotator cuff repair with biocomposite implants with bioinductive properties such as collagen sc... | This biocomposite implant provides an encouraging option for use in patients with poor tissue quality or tear patterns that are concerning for possible postoperative retear. | Compared to controls, genipin treatment increased ultimate force by 19% in degenerated tendons (median control 530 N vs. 633 N; p = 0.0078). No significant differences in mechanical properties were observed in healthy tendons, while degenerated tendons showed a significant difference in ultimate stress (+23%, p = 0.049... | The shift of COL1/2 ratio toward COL2A1 was more pronounced in HA, and cells displayed a more spherical morphology compared with CS. BMP-2 and IL-10 significantly increased COL2A1, SOX9, and ACAN expression, which was paralleled by enhanced staining of glycosaminoglycans (GAGs) and type 2 collagen in histological secti... | Observations revealed a statistically significant loss of sulphated glycosaminoglycan (sGAG) using both Collagenase Treatment (CT) and Collagenase and Aggrecanase Treatment (CAT), while chondrocytes viability was maintained. Both treatments resulted in a significantly elevated release of inflammation markers during the... | The in vivo histology of the graft site after 3 years has shown that heterologous bone is a safe and valid choice as a scaffold for bone regeneration. Augmentation with NHA bone paste achieved good osteoinduction without an inflammatory reaction and good integration of the bone substitute insert. | Micro-CT indicated adequate volume stability in all block materials. Histologically, the addition of rhBMP-2 increased the amount of newly formed bone (NB) in all the blocks. At 2 weeks, minimal differences were noted among the NB of groups with or without rhBMP-2. At 12 weeks, the PBC+M group with rhBMP-2 presented th... | 42311585 | Ochsner journal | [
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Title: A multicenter retrospective analysis of canine idiopathic epilepsy in China. Background: Canine idiopathic epilepsy (IE) is one of the most common neurological diseases in veterinary medicine, with no comprehensive study in China. This study collected IE cases from five large referral pet hospitals and conducted... | A total of 211 cases with IE were included in the study. Male dogs (<i>p</i> < 0.05), small dogs weighing <10 kg (<i>p</i> < 0.05), poodles (<i>p</i> < 0.05) had a significantly higher risk to be diagnosed with IE. The age of first seizure episode was mainly between 1 and 5 years, with an average of 4 years. Most patie... | Dogs with rostrotentorial brain tumors had EPS after 16/125 (12.8%) neurosurgical procedures (95% confidence interval [CI], 7%-19%). Presence of previous structural epilepsy was not associated with EPS risk (P = 1). Perioperative ACD use also was not associated with EPS (P = .06). Dogs with EPS had longer hospitalizati... | Ambulatory EEG was diagnostic in 60.2% of all dogs including 49% of the sedation/GA dogs and 68% of dogs that received neither (odds ratio [OR], 2.25; 95% confidence interval [CI], 1.02-5.00; P = .05). The AEEG was diagnostic in 51% of dogs receiving at least 1 ASD and 66% of untreated dogs (OR, 1.95; 95% CI, 0.9-4.3; ... | Lissencephaly should be considered an important differential diagnosis in Shih Tzu dogs presenting with early-onset signs of forebrain abnormalities, including cluster seizures and behavioral alterations. Magnetic resonance imaging was appropriate for ante-mortem diagnosis of lissencephaly and associated cerebral anoma... | Breeds represented most often included the Golden Retriever (n = 12), Bernese Mountain Dog (10), Wirehaired Pointing Griffon (9), Boxer (9), and Beagle (6). No breed differences were identified with respect to clinical severity, diagnostic findings, or outcome. Twenty-nine dogs (48%) had ≥1 disease relapse. There was a... | Two hundred seven dogs could be assigned to IVETF response categories 1-3. The proportion of responders (59%, n = 123), including categories 1 (29%) and 2 (30%), was higher than non-responders (category 3, 41%, n = 84; P < .01). Based on the responders, an RI of 10-55 μg/mL is proposed. This study demonstrated that ZNS... | 42311395 | Frontiers in veterinary science | [
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Title: Thickness distribution and site-specific variability of thermoformed multilayer clear aligners: an <i>in vitro</i> study. Background: Thermoforming is a critical step in the fabrication of clear aligners and is associated with non-uniform deformation of thermoplastic materials, resulting in non-uniform thickness... | Significant differences in thickness were observed among tooth regions (<i>p</i> < 0.001), with the lowest values in anterior teeth (404.0 ± 5.9 µm) and the highest in molars (481.6 ± 6.0 µm). Thickness reduction ranged from approximately 36% to 47% relative to the original material. Site-specific analysis demonstrated... | Eleven publications were included in this review (4 CCTs and 7 RCTs). No study presented low risk of bias. Different types of tooth movement were evaluated: lower anterior alignment, en-masse retraction, overall orthodontic treatment and canine distalization. A total of 240 participants were analyzed in the included st... | : All CAT-based total distalization groups showed an overall trend of clockwise or counterclockwise rotation of the occlusal plane as the force direction varied. Mesiodistal tipping of individual teeth was more prominent than that of bodily movements. The initial displacement pattern of the mandibular teeth was more pr... | Dental anomalies have multiple effect on the occlusion as well as on the esthetic. Early diagnosis and intervention and collaboration between the different subspecialty are needed. Pedodontics, orthodontic, restorative, and prosthodontic consultation was taken for the best future proposed treatment that ranges between ... | VLPPP showed the highest tooth displacement pattern of 0.017 mm with incremental rotational force application but also exhibited highest stress concentration at PDL and alveolar bone level of 516.10 Mpa. VL showed the least tooth movement of 0.012 mm and lowest stress levels of 374.33 Mpa. VLPPP generated the highest f... | The integration of multiloop orthodontic mechanics and periodontal crown lengthening represents a predictable and comprehensive interdisciplinary strategy for managing deep bite with a gummy smile, resulting in significant improvements in occlusion, tooth proportions, and facial esthetics. | 42306039 | Frontiers in dental medicine | [
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Title: Next frontier in endovascular aortic therapy: An anatomic analysis of feasibility of endovascular treatment of ascending thoracic aortic aneurysms. Background: Ascending thoracic aortic aneurysms (ATAAs) are the next frontier for endovascular aortic repair. This study evaluates anatomic characteristics of ATAAs ... | In total, 150 consecutive patients with ATAA ≥5 cm and high-quality computed tomography scans were included. A diameter between 27 and 48 mm existed in 46% (69/150) of patients at the proximal landing zone and 94% (141/150) at the distal landing zone. Arch branching was normal in 68% (102/150), bovine in 21% (38/150), ... | Despite the relevant perioperative morbidity and mortality associated with EVAR infection, endograft explantation and in situ reconstruction with preferably bovine pericardial grafts may offer definitive treatment of infection, with promising mid- and long-term results. | From July 2017 to July 2018, 60 patients underwent implantation of the Dafodil pericardial bioprosthesis. Post-operatively, NYHA functional class significantly improved in all the patients (Aortic: 90% NYHA class-I and 10% NYHA class-II; Mitral: 96.55% NYHA class-I and 3.45% NYHA class-II; P < 0.001). There was no deat... | A 68-year-old male was admitted to the hospital due to severe abdominal pain. The patient was afebrile, hemodynamically stable with elevated C-reactive protein levels. A physical examination revealed a palpable, pulsatile, tender mass located in the periumbilical region. Ultrasonography and multi-slice computer tomogra... | In the present case, prompt treatment decisions and smooth cooperation among the institutional heart team led to the successful repair of aortic root rupture during TAVI and good clinical outcomes. | This case illustrates a successful approach to orthotopic heart transplantation in a child with failing Fontan circulation supported by a VAD. Reconstruction of the pulmonary artery using a large pericardial patch and restoration of bicaval continuity were key to overcoming complex anatomical challenges. | 42305689 | JTCVS structural and endovascular | [
0.5221665501594543,
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0.3539655804634094,
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] |
Title: Congenital central nervous system malformations in piedmontese calves-part 1. structural brain disorders. Background: Congenital central nervous system (CNS) malformations in cattle are likely underreported, and their true incidence, clinical spectrum, and etiological factors remain poorly characterized. This st... | In total, 70 calves underwent necropsy for suspected CNS anomalies. Structural brain defects were confirmed in 11 calves. Hydrocephalus (6/11) was the most frequent finding and was commonly associated with cerebellar malformations. Isolated Dandy-Walker-like malformations were found in 2/11 and cerebral aplasia in 3/11... | The prosencephalon was the most commonly affected location (81 cases, 19.6%), followed by multifocal involvement (62 cases, 15%) and the T3-L3 spinal cord (56 cases, 13.5%). Infectious diseases, especially canine distemper diseases, were the most common cause, accounting for 136 cases (33.2%). Unknown causes ranked sec... | Fifty-two horses had EPM; 23 were confirmed on necropsy, and 29 were presumptive clinical diagnoses. The other 47 horses all had necropsy-confirmed diagnoses. Four of the 47 horses had normal neurologic findings on necropsy and the remaining 43 horses had neurologic diseases including equine degenerative myeloencephalo... | This is the first case in veterinary literature in which a grass awn has been surgically extracted from the brain of a dog with long-term outcome described. Observed changes in the extracranial musculature were fundamental to establish the pre-surgical diagnosis of a migratory foreign body. | One hundred eighty-eight patients were included in the study with a median age of 6.9 years (range 3 months to 14.6 years). Neurological abnormalities included head tilt (n = 185), ataxia (n = 123), facial paralysis (n = 103), nystagmus (n = 97), positional strabismus (n = 93) and Horner syndrome (n = 7). The most prev... | Electronic clinical records at our veterinary referral hospital between April 2009 and November 2018 were searched for patients presented with cervical myelopathy secondary to an underlying suspected vertebral malformation/instability. Nine dogs met the inclusion criteria. Two dogs were diagnosed with atlantoaxial pseu... | 42305400 | Frontiers in veterinary science | [
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Title: Development of a low-cost external fixation system: an off-label solution for resource-limited settings. Background: External fixators are essential for the surgical management of long-bone fractures, particularly in resource-limited settings where access to commercial systems is often restricted by cost and log... | CG showed the highest stiffness (107.80 ± 14.12 N/mm), followed by SP (87.73 ± 17.92 N/mm), BKS (83.81 ± 10.01 N/mm), KS (49.84 ± 3.80 N/mm), and KT (46.66 ± 2.39 N/mm). Post-hoc analyses showed no significant differences between CG vs. SP and CG vs. BKS, whereas KT and KS were significantly less stiff. Elastic deforma... | The overall pathologic fracture rate was 37%. Pathologic fracture rate was significantly higher for dogs that received F-RT (5/6, 83%) compared to dogs that received C-RT (12/40, 30%, p = 0.021). In the 17 dogs that fractured, the overall median time to fracture was 57 days. For all dogs, the median progression free in... | The in vivo histology of the graft site after 3 years has shown that heterologous bone is a safe and valid choice as a scaffold for bone regeneration. Augmentation with NHA bone paste achieved good osteoinduction without an inflammatory reaction and good integration of the bone substitute insert. | The bone stresses were increasing in the models by using OMI covered with a revolving cap as compared with that in the conventional model (in which only the OMI was placed). However, no obvious differences in bone stresses were observed among the models with various types of angled revolving cap. The minimum principal ... | The Five-Implant model exhibited the most favorable biomechanical outcomes, demonstrating the lowest stress and strain values across prosthesis, implant components, and cortical bone. The Trefoil system showed the highest prosthetic stress (156.48 MPa axial; 119.32 MPa oblique) and abutment screw deformation, attribute... | Overall mean total costs for Tx and re-Tx of both WSLs and cavitations may sum up to 1718.91 Eur in the high-cost (GOZ 3.5) scenario for conventional MB cases, versus 19.94 Eur for lingually treated cases, given that renewal of simulated single-surface restorations takes place at 15-year intervals. When focussing on pa... | 42301298 | European journal of trauma and emergency surgery : official publication of the European Trauma Society | [
0.4733087420463562,
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Title: Efficacy of Vitex pseudo-negundo in a Bovine Mastitis Model Experimentally Induced by Staphylococcus aureus in Rats. Background: Mastitis is one of the most prevalent and economically significant diseases in dairy cattle, causing to inflammation of the mammary gland and reduced milk yield. This study investigate... | SA infection significantly increased mammary gland weight, total oxidative status (TOS) and bacterial load and induced tissue pathology, while decreasing total antioxidant status (TAS). C-reactive protein levels remained unchanged. VPN significantly improved mammary gland weight, TOS, TAS, bacterial load and histologic... | As a result, we showed that the assay for S. uberis detection demonstrated a specificity of 89.02%, a sensitivity of 43.59%, and an accuracy of 80.3%. In turn, the second variant - assay for Gram-positive cocci reached a specificity of 95.59%, a sensitivity of 43.28%, and an accuracy of 78.33%. Our study shows that EF-... | The overall prevalence of subclinical mastitis in she-camels was 10.6% (26/244), with no significant difference among the studied dairy farms. Risk factors that influenced the result of California Mastitis Test (CMT) included age and udder and leg hygiene. The study revealed that <i>S. aureus</i> was the most prevalent... | The overall bacteriological cure was observed in 10/40 (25%) cows in the P-PRP group, 9/28 (32.14%) animals in the SC group, 26/36 (72.22%) cows in the P-PRP+SC group, and 10/26 (38.46%) animals in the NCG. SCM caused by <i>S. aureus</i> (82/130, 63.08%), was cured in 6/24 (25%) cows treated with P-PRP, 7/24 (29.2%) co... | The results of Experiment 1 showed that administration of ATC improved growth performance and antioxidant functions in the serum and the liver, as well as immunoglobulin A, G, and M levels in rat serum, and it decreased the content of alanine aminotransferase, aspartate aminotransferase, triglyceride, cholesterol, low-... | Compared with autoclave sterilization, syringe filter sterilization resulted in less (p<0.05) phenolic and flavonoid contents. Against <i>Escherichia coli</i> and <i>Staphylococcus aureus</i>, the filter sterilized herbal formula (<i>E. coli</i>: 65.9%-73%; <i>S. aureus</i>: 6.2%-18.1%) markedly reduced the antibacteri... | 42299878 | Veterinary medicine and science | [
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] |
Title: Microcomputed tomographic comparison of the bony structure of the canine and feline carpus. Background: Feline carpal joint injuries pose a significant clinical challenge due to their complex anatomy and the limited evidence available to guide treatment decisions. A detailed understanding of the osseous microarc... | All carpal bones exhibited a cancellous structure. Overall, cats had fewer but thicker trabeculae than the toy-dogs in the analysed areas of the carpus, which resulted in a greater trabecular distance in cats. Cats also had a higher bone volume (BV/TV) and thicker cortex. There were significant differences in structure... | The mandibular incisive canal was identified in 74.5% of patients and 60.6% of CBCT images. The mean length and diameter of the MIC were 13.7 ± 3.90 mm and 1.65 ± 0.55 mm, respectively. No statistically significant differences in MIC visibility were found across age groups or between edentulous and dentate patients. Me... | From 455,069 dogs under veterinary care, the one-year period prevalence for elbow joint disease diagnosis was 0.56% (95% CI: 0.53-0.60). Of 616 incident cases, the most common specific variants of elbow joint disease were osteoarthritis (<i>n</i> = 468, 75.97%), elbow dysplasia (190, 30.84%) and traumatic (41, 6.66%). ... | The most frequently diagnosed tarsal injuries were fracture of the central tarsal bone (CTB; 57.8%), calcaneal fracture (56.9%) and proximal intertarsal subluxation (34.5%). The most common injury combination was a CTB fracture with a calcaneal fracture (31.9%). In total 115 (99.1%) survived to discharge. Of these, 46 ... | All the dogs in group I were considered healthy. In these dogs, the mean radioulnar "step" height based on the X-ray examination was 0.85 ± 0.33 mm, the mean joint space width of the humeroulnar joint assessed in the computed tomography (CT) examination was 1.34 ± 0.34 mm, and the mean joint space width of the humerora... | More than 40 MIO articles have been published in the last 15 years, but most studies had small numbers, lacked control groups, and used limited outcome measures. Studies generally showed that MIO was feasible in dogs and cats with low complication rates. The current evidence does not demonstrate superior bone healing o... | 42298672 | Acta veterinaria Scandinavica | [
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] |
Title: Prevalence and Grade of Patellar Luxation in Cavalier King Charles Spaniels Attending Primary-Care Veterinary Practices in Australia. Background: To identify risk factors associated with the prevalence and grade of patellar luxation in Cavalier King Charles Spaniels (CKCSs) attending Australian veterinary practi... | The 10-year prevalence of patellar luxation in this study was 12.5% (95% confidence interval [CI], 0.12-0.13). The greatest risk of patellar luxation diagnosis was in neutered dogs (odds ratio (OR): 3.00; 95% CI, 1.97-4.71) and dogs weighing 11 to < 13 kg (OR: 2.52; 95% CI, 1.49-4.39). Dogs 10 years or older had the lo... | Weight distribution, joint range of motion at flexion and extension, thigh girth, digital thermography, and radiographic signs were collected. Data from different Clinical Metrology Instruments (CMI) were collected: Canine Brief Pain Inventory, Liverpool Osteoarthritis in Dogs, Canine Orthopedic Index, and the Hudson V... | Only 24/429 dogs met all enrollment criteria; 379/429 dogs lacked BALF collection. Diagnosis of b-AP differed using veterinary (79%) vs human (29%) medical criteria. Fever, band neutrophils and high radiographic scores were noted in dogs with and without b-AP. Lack of routine BALF collection hampers definitive recognit... | Multivariate models using the specimens showed that filter paper fixation of endoscopic samples resulted in a higher GSHA score than floating fixation in both dogs (ordinal odds ratio [OR]: 0.19; 95% confidence interval [CI]: 0.15-0.25) and cats (ordinal OR: 0.19; 95% CI: 0.13-0.29). In dogs, the scores were lower for ... | The study included a random sample of 22,333 dogs. The 1-year period prevalence for diagnosis with periodontal disease was 12.52% (95% CI: 12.09 to 12.97). Eighteen breeds showed increased odds compared with crossbred dogs. Breeds with the highest odds included Toy Poodle (odds ratio 3.97, 95% confidence intervals 2.21... | Thermal imaging revealed differences between the two groups of dogs, which were further supported by significantly higher temperatures in the El1 (lateral aspect of the stifle joint) and Bx1 (cranial aspect of the stifle joint) areas in the study group compared to the control group using a comparative analysis-two-samp... | 42295730 | Veterinary medicine and science | [
0.744225025177002,
0.4623982310295105,
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] |
Title: Synergistic antibacterial effect of CATH-2 and D-amino acids against mastitis causing gram-positive bacteria. Background: To effectively treat bacterial diseases caused by antibiotic-resistant strains, new antimicrobial agents are needed to overcome this resistance. This study explored whether the combination of... | The combination of CATH-2 and D-arginine showed strong synergistic antibacterial activity against Gram-positive bacteria, including all tested multidrug-resistant clinical <i>Staphylococcus aureus</i> isolates, in both LB medium (FIC = 0.37) and fresh raw milk (FIC < 0.12). No detectable cytotoxic effects on bovine udd... | Of the 200 positive CMT cattle, 24 animals were positive for <i>S. aureus</i> and confirmed using <i>16S rRNA</i> gene amplification. Statistical analysis showed that the phenotypic and genotypic tests of hemolysin genes were not significantly different (P>0.01). PCR analysis revealed the presence of <i>coa</i> and <i>... | The bacterial composition and diversity analysis of milk samples before and after probiotic administration was analyzed using 16S rRNA gene base metagenomic analysis and lactobacillus counts were also evaluated using Real time PCR. The results show that there was an increase in abundance of Proteobacteria and decrease ... | Of the 220 outlets, 74 (33.6%) were agro-veterinary shops and 146 (66.3%) retail pharmacies. Overall, 126 outlets did not stock veterinary medicines for mastitis. Among the 94 that did, 85 (90.4%) dispensed antibiotics and 9 (9.6%) dispensed other medicines without a prescription. Of the 134 veterinary medicines dispen... | Overall, 198 enterococcal isolates were identified from 2897 mastitis samples, including 137 (4.7%) <i>E. faecalis</i>, 50 (1.7%) <i>E. faecium</i> and 11 (0.4%) <i>E. hirae. E. faecalis, E. faecium</i> and <i>E. hirae</i> isolates showed high resistance to tetracycline (92.7%, 68.0%, 90.9%), followed by erythromycin (... | Our findings revealed that 73% (146/200) of the examined milk samples collected from dairy cows with clinical mastitis were infected with Streptococci species. Of these, 9.59% (14/146) were identified as S. agalactiae and categorized as MDR. S. agalactiae isolates expressed four virulence genes (Hyl, cylE, scpB, and lm... | 42291332 | Frontiers in cellular and infection microbiology | [
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] |
Title: Efficacy and safety of supplementation of Exclzyme Pet for the management of arthritis and inflammatory symptoms in dogs: a randomized, double-blind, placebo-controlled pilot trial. Background: A randomized, double-blind, placebo-controlled interventional pilot trial was conducted to evaluate the safety and effi... | Exclzyme Pet resulted in a statistically significant reduction in scores for lameness, weight bearing, joint mobility, willingness to hold up contralateral limb, and pain by 51.96, 46.94, 48.94, 58.0, and 55.56%, respectively and demonstrated clear superiority over placebo. The overall quality of life, mood, and mobili... | The median PFS was significantly longer in the RAB group compared to placebo (82 vs 21 days; P < .0001, HR 6.265 [95% CI 3.947-9.945]). The BORR for RAB-treated dogs was 73.2% (50.9% complete response [CR], 22.3% partial response [PR]) and 5.6% (0% CR, 5.6% PR) for placebo-treated dogs (P < .0001). One month after the ... | The review identified 27 relevant articles on the effects of ECSWT in horses, nine in dogs, but none in cats. Typically, ECSWT involved one to three treatment sessions at 1- to 3-week intervals. We identified studies on bone mass and bone healing, wound healing, navicular disease, ligament injury, desmitis, sesamoiditi... | Eleven dogs were enrolled. Stable disease was achieved in two of eight dogs available for response assessment. The median progression-free survival was 28 days (range: 4-93 days). The median stage III-specific survival time was 92 days. Adverse events were reported in four dogs; two dogs developed grade III or higher t... | A diagnosis of osteoarthritis was confirmed by a veterinarian in 38% (188 of 500) of dogs. Balance of sensitivity and specificity across the original group of nine screening questions was optimised to approximately 88 and 71%, respectively, after elimination of three questions. Pain measured by Helsinki Chronic Pain In... | Three days after surgery, grapiprant treated dogs had lower PSS compared to meloxicam treated dogs with a mean ± SD of 2.76 ± 0.18 vs 3.25 ± 0.23, respectively (difference of -0.49 [95% CI -0.94 to -0.04], P = .032). Pain Interference Score was also lower in grapiprant group at day 3 (4.11 ± 0.18 vs 4.69 ± 0.16 in melo... | 42290785 | Frontiers in veterinary science | [
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] |
Title: Topical betulinic acid for treatment of equine melanoma and sarcoid. Background: Betulinic acid, a natural pentacyclic triterpenoid, has demonstrated anti-inflammatory and anti-tumor properties in vitro, including activity against equine melanoma and sarcoid. However, there is limited in vivo evidence evaluating... | A total of 37 horses completed the study, including 16 with melanoma and 21 with sarcoid tumors. There were no statistically significant differences in tumor volume change between treatment and placebo groups for either tumor type. Tumor volume decreased in a proportion of cases across all groups. The treatment was wel... | Based on four books and a survey among veterinarians specialized in phytotherapy, four medicinal plants were chosen as the subject of this systematic review: Calendula officinalis L. (Marigold), Hypericum perforatum L. agg. (St. John's Wort), Matricaria chamomilla L. (syn. Matricaria recutita L., Chamomile) and Salvia ... | Forty-five compounds were identified in a primary screening that showed tumor-selective inhibitory activity against lymphoid tumor cells. Based on the literature, five compounds (artesunate, niclosamide, pentamidine, itraconazole, and dronedarone) were selected for secondary screening. All the five compounds exhibited ... | Treatment of <i>L. major</i> infected BALB/c mice with nanoliposomal curcumin led to a reduction in the kinetic of the skin lesion size development. The semi quantitative PCR analysis of DNA extracted from the lesions showed reduction of parasite burden. The most effective treatment could be found in 80 μM nanoliposoma... | A total of 152 horses was included. The most common signs were poor performance (68%), nonspecific pain (43%), and irritation/aggression (41%). Intestinal signs were observed in 63% of horses. Sixty-six percent of horses had ultrasonographic changes in the small intestine, and 37% had gastric ulcers. Orthopaedic examin... | A single TT treatment resulted in 75% complete response (CR) (95% confidence interval [CI] = 61-86) by 28 days, with no recurrence in 93% (95% CI = 82-97) of dogs by 84 days. Eight TT-treated dogs that did not achieve CR in phase 1 achieved CR after retreatment, increasing the overall CR to 88% (95% CI = 77-93). Contro... | 42290780 | Frontiers in veterinary science | [
0.5024169683456421,
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Title: Variations in the management of canine osteoarthritis: a cross-sectional survey of veterinary practices. Background: There is limited data on how veterinarians implement multimodal therapies for managing canine osteoarthritis (OA). The primary aim of this study was to describe how OA is managed by veterinarians ... | 373 responses were analyzed. Non-steroidal anti-inflammatory drugs (NSAIDs) were the most prescribed drug class, and gabapentin, bedinvetmab, and polysulfated glycosaminoglycan (Adequan<sup>®</sup>) were the most prescribed non-NSAID medications. The most used nutraceutical and non-pharmacologic treatments were omega-3... | Twenty dogs were enrolled in the study. In both groups there was an increasing values of ground reaction forces. These results might indicate that both nutraceutical products determined a better condition in terms of pain feeling but that effect is much more visible after 60 days from the end of the administration in t... | Dogs treated with four weekly injections of HA or two biweekly injections of HA-PRP were significantly (p < 0.05) better than dogs treated with four weekly injections of saline at 2-, 4-, and 12-week time points based on a comfortable range of motion (CROM) and clinical lameness score. Gait analysis measuring symmetry ... | Ten dogs with clinical signs of SA, nine with osteoarthritis (OA, control group) and nine with clinical signs of immune-mediated polyarthritis (IMPA, second control group) were examined. Bacterial culture was positive in seven of 10 dogs with clinical SA, of which only two were positive by 16S rRNA PCR. The sensitivity... | Veterinarians and students both reported feeling more blame, frustration, and disgust toward dogs with obesity and their owners than toward lean dogs and their owners (p values < 0.001). Interactions between dog and owner body weight emerged for perceived causes of obesity, such that owners with obesity were perceived ... | The sample was composed of 92 males and 73 females, with a mean age of 5.2 ± 3.2 years. Four main dog breeds were represented, 60 Belgian Malinois Shepherd Dogs, 52 German Shepherd Dogs, 29 Labrador Retrievers, and 14 Dutch Shepherd Dog. A prevalence of diarrhea of 10.6% was determined, with 4% of dogs having liquid di... | 42290771 | Frontiers in veterinary science | [
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] |
Title: Multi-target synergistic mechanisms of flavonoid compounds from traditional Chinese medicine in non-alcoholic fatty liver disease: insights for human and veterinary medicine. Background: Non-alcoholic fatty liver disease (NAFLD) is a prevalent chronic liver disorder characterized by dysregulated hepatic lipid me... | Existing research evidence demonstrates that TCM flavonoids improve NAFLD through multiple core regulatory pathways. These compounds reverse hepatic lipid metabolism disorders by activating the <i>AMPK/SIRT1</i> and <i>PPARα</i> signaling pathways, inhibit lipogenesis by suppressing the key lipogenic factor <i>SREBP-1c... | The present study revealed that MGN rats treated with ILQ showed significantly ameliorated kidney dysfunction and histopathological changes in kidneys. ILQ treated MGN rats alleviated the oxidative stress and were presented with increased anti-oxidative status in kidneys. Furthermore, ILQ treatment to MGN rats showed a... | We established an in vitro bovine fatty liver cell model and conducted a comprehensive analysis of cells treated with TMAO using high-throughput omics sequencing technologies. Bioinformatics methods were employed to delve into the regulatory effects on lipid metabolism, and several key genes were validated through RT-q... | GLU and FRU concentrations in the RYGB group were significantly lower than in diabetic controls (<i>p</i> < 0.05), remaining comparable to the insulin-treated group (<i>p</i> > 0.05). Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities were significantly reduced post-RYGB (<i>p</i> < 0.05), c... | Results showed that supplementation effectively reduced proteinuria, blood urea, and phosphorus levels, stabilized creatinine and SDMA, and maintained blood pressure. It also improved markers of systemic inflammation and oxidative stress. The once-daily dosage simplified administration and was especially beneficial for... | K/X significantly (P < 0.05) increased blood glucose at 30, 60, 90, and 120 min, decreased insulin levels, and induced oxidative stress, which was accompanied by an increase in pro-inflammatory cytokines. Berberine (5 and 20 mg/kg) and yohimbine (2 mg/kg) significantly reduced blood glucose and increased insulin levels... | 42283012 | Frontiers in veterinary science | [
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0.4392980933189392,
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] |
Title: Combined Effects of Arsenic and Cadmium With Selenium on Oxidative Stress Indicators in Goldfish: Implications for Veterinary Toxicology. Background: The individual and combined effects of toxic heavy metals, including arsenic (As) and cadmium (Cd) and their interactions with selenium (Se), play a crucial role i... | Body weight increased in all treatment groups compared to initial values. Co-exposure to Se significantly reduced As accumulation, with tissue concentrations decreasing from 0.16 ± 0.02 mg/kg in the As group to 0.10 ± 0.009 mg/kg in the combined exposure groups (approximately 62 % reduction; p < 0.05). In contrast, Cd ... | Hematological reference indices were generated for the aforementioned equine breeds in Western Libya. The equine hematological profile was variable according to some individual and management factors. In addition, the significant effects of those factors were usually restricted to erythrocyte- and platelets (PLTs)-rela... | All short- (C2-C5) and medium-chain (C6-C12) AC in blood differed significantly (<i>p</i> < 0.008) between horses with AM and controls, except for C5:1 (<i>p</i> = 0.45) and C5OH + C4DC (<i>p</i> = 0.06). In AM survivors the AC concentrations decreased over time but were still partially elevated after 7 days. 14/62 (23... | Iron accumulated within chondrocytes, which was associated with programmed cell death through chondroptosis. Iron treatment increased the release of sulfated glycosaminoglycans (sGAG), a component of the extracellular matrix, into the medium (p=0.0189). This was dependent on the presence of viable chondrocytes and was ... | The deltamethrin significantly increased AST, ALT, ALP, and the level of ROS level at the end of 1 and 24 <i>hr</i> after treatment; while the LDH level and GSH content were decreased. Mice in the deltamethrin treated group had a higher liver/body weight ratio than in other treated groups after 24 <i>hr</i>. On the oth... | Seven days of treatment resulted in a mycophenolic acid (MPA) area under the curve (AUC<sub>0-12</sub> ) of 12 594 h × ng/mL (8567-19 488 h × ng/mL) and terminal half-life (T<sub>1/2</sub> ) of 11.3 hours (7.5-15.9 hours), yielding minor metabolite accumulation in all horses treated. Salmonellosis was detected in the f... | 42281510 | Veterinary medicine and science | [
0.7645283341407776,
0.4131941497325897,
0.3718166649341583,
0.36468198895454407,
0.36226582527160645,
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] |
Title: Early Protraction Facemask Followed by Fixed Appliance Therapy in a Growing Patient With Skeletal Class III Malocclusion: A Case Report. Background: Skeletal Class III malocclusion remains a significant orthodontic challenge because of its multifactorial aetiology, strong genetic influence, and the unpredictabil... | This case highlights that biologically timed protraction facemask therapy, even when initiated beyond the conventional early age, combined with careful case selection and comprehensive fixed appliance treatment, may achieve favourable functional and aesthetic outcomes in selected growing patients with borderline skelet... | After applying significantly different traction forces to the maxillary tissues on both sides of the patient, the patient was treated with appropriate traction correction, orthodontic treatment and moderate traction on the facial arch to effectively reduce the recurrence of the disease after surgery. Compared with the ... | This study demonstrated that after occlusal adjustment, the maxilla showed significant increases in intermolar width, intercanine width, and arch Circumference compared with the controls after six months post-debonding (p = 0.009, 0.011, 0.041). In the mandible, the changes in intermolar width and arch Circumference we... | These results suggest that surgically assisted and implant anchored-orthodontic approaches might be effective for the correction of such malocclusions. | Higher stresses were observed in mandibular dentition with the inter-radicular implant system. The amount of von Mises stress was higher for cortical bone (85.66MPa) and cancellous bone (3.64MPa) in Case 2, in comparison to cortical bone (41.93MPa) and cancellous bone (3.43MPa) in Case 1. The amount of arch distalizati... | A statistically significant increase during treatment was observed for all maxillary teeth transversal distances (p< 0.05). In turn, a significant reduction was observed in the long term (p< 0.05). For the mandibular teeth, canine transversal distance presented statistically significant constriction in the retention pe... | 42272660 | Case reports in dentistry | [
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0.5609597563743591
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Title: Analytical validation, reference interval determination, and diagnostic performance of plasma symmetric dimethylarginine in cattle. Background: The efficacy of serum urea and creatinine concentrations in the diagnosis of kidney disease in cattle is limited because of their low sensitivity and specificity. Serum ... | The SDMA measurements showed acceptable analytical performance. The reference interval was 60-160 μg/L. No significant differences were found according to sex, breed, or food supply. Using the upper limit of the reference interval (160 μg/L) as the cut-off, sensitivity and specificity were 0.85 and 0.98, respectively. ... | Plasma samples measured with the CA showed on average 2.3 (EDTA) and 2.5 (LH) times higher Hp concentrations compared with serum, whereas no differences were seen with the ELISA results between sample types. Based on a clinical cut-off value, both methods differentiated sick from healthy cows. Haptoglobin measurements ... | A higher US chronic kidney disease (US-CKD) score of the kidney contralateral to the UO was associated with long-term IRIS stages III and IV. It also appeared as a fair discriminator of long-term IRIS stage IV, with an area under the curve of 0.74. The optimal cutoff value for accurately identifying cats with long-term... | Ninety CE dogs were included. Fifty-two dogs had mild-to-severely decreased MCS and 38 dogs showed altered urinary parameters. No significant associations were found between CCECAI and altered urinary parameters. No significant association was found between PLE dogs and altered urinary parameters. PLE dogs showed highe... | Fifty-eight percent (n = 31/53) of proteinuric cats had ICGN and 74% (n = 31/42) of cats with PLN had ICGN. Cats with glomerular diseases other than ICGN had a higher median urine protein:creatinine ratio than ICGN cats (14.5 vs 6.5; <i>P</i> <0.001). Onset of PLN occurred at a young age; median age at diagnosis was 3.... | We found detectable concentrations of SAA, Hp and LBP in pharyngeal swabs from calves, as well as in TA and serum. There were no biologically interesting correlations between the SAA concentrations in serum and TA or pharyngeal swabs. This also applied to Hp and LBP concentrations in serum and TA or pharyngeal swabs. S... | 42263210 | Journal of veterinary internal medicine | [
0.7567321062088013,
0.5402815341949463,
0.4942752718925476,
0.5189762711524963,
0.5112869143486023,
0.47863927483558655
] |
Title: Validation of a Pregnancy-Associated Glycoprotein-Based Lateral Flow Assay for Early Pregnancy Detection in Goats. Background: The significant cross-reactivity between bovine, ovine, and caprine pregnancy-associated glycoproteins (PAGs) enables the adaptation of bovine-specific diagnostics for use in other rumin... | Results indicated that on Day 21, AOFPT sensitivity, specificity, positive predictive value, and negative predictive value were 79.4%, 93.8%, 98.2%, and 51.7%, respectively. By Day 28, these metrics reached 100%, 81.3%, 95.8%, and 100%. Statistical agreement between AOFPT and the reference method was K = 0.55 (82.14%) ... | Medical records of 187 goats and 434 sheep were included in the analysis of this study. Females were significantly more represented in the study population for goats and sheep, 87.70% and 84.10%, respectively. The age of animals ranged between 1 day and 9 years in goats and 1 day and 7 years in sheep. In both goats and... | We found detectable concentrations of SAA, Hp and LBP in pharyngeal swabs from calves, as well as in TA and serum. There were no biologically interesting correlations between the SAA concentrations in serum and TA or pharyngeal swabs. This also applied to Hp and LBP concentrations in serum and TA or pharyngeal swabs. S... | The RIs for cardiac serum biomarkers included in the present study were generally within the reference range provided for sheep with slight variations which might be attributed to physiological adaptation to harsh desert climate. The Na<sup>+</sup> significantly (<i>p</i> ≤ 0.05) predicted AST (adj. <i>r</i>-square = 0... | Pathogenic <i>Leptospira</i> spp. DNA was detected by lip<i>L32</i> PCR in at least one anatomical site in 55% (22/40) of animals. The highest positivity rate was observed in UB (20/40; 50%), whereas AUH (7.5%), BUH (0%), and OVID (2.5%) showed no or minimal detection. The findings demonstrate that pathogenic <i>Leptos... | Of the 368 proteins, 84 were detected in CSF and 146 in serum. Eighteen of 84 proteins in CSF and 30/146 in serum were differentially abundant among the 3 groups, after correction for multiple testing. Modeling indicated that a 2-protein test using CSF had the highest accuracy for discriminating among all 3 groups. Cer... | 42262719 | Veterinary medicine and science | [
0.7194649577140808,
0.5547218918800354,
0.4824220836162567,
0.45911213755607605,
0.4818534553050995,
0.4560549855232239
] |
Title: Effect of occlusal adjustment on post-orthodontic relapse in extraction cases: a randomized clinical trial. Background: Maintaining post-treatment occlusal stability remains a major challenge in orthodontics. Premature occlusal contacts may contribute to relapse. This study aimed to evaluate the effect of select... | This study demonstrated that after occlusal adjustment, the maxilla showed significant increases in intermolar width, intercanine width, and arch Circumference compared with the controls after six months post-debonding (p = 0.009, 0.011, 0.041). In the mandible, the changes in intermolar width and arch Circumference we... | Forty subjects (mean age 13.7 ± 2.1 years) with 43 IMC and 47 incisors with CIRR were recruited. The IMC either spontaneously erupted, were surgically exposed or surgically removed. Thirty-four of the patients were treated with a fixed appliance and six had no orthodontic treatment. The follow-up range was 5.5-14.6 yea... | Radiograph revealed all of the tumors before orthodontic treatment. CBCT is appropriate to use for surgical approach, and it minimizes complication. An OPG is less costly compared to CBCT. Odontomas were treated by surgical removal because the tumor blocked the pathway of tooth eruption and medialized or distalized tee... | Mean rotational correction was 14.05° during posttreatment. Mean relapse at 1-year follow-up was 1.1° (10.8%). More than half (<i>n</i> = 52, 57.8%) of teeth were categorized as having unnoticeable relapse (0°). Of the remaining teeth, 31 (34.5%) had barely noticeable relapse (1°-3°), 6 (6.6%) had noticeable relapse (4... | Preoperative orthodontic decompensation determines the discrepancy and maximizes mandible repositioning. The technique improves surgical planning and therapy outcomes. This case report describes the "Hunsuck modification fracture pattern," which is a type of fracture that has a horizontal cut behind the lingula and a v... | After controlling for confounding variables, there was a 1.64 mm (95% confidence interval [CI], 0.30, 2.98 mm) median between-groups difference among patients who utilized vacuum-formed retainers (VFRs). The treatment groups did not vary in inter-canine and intermolar widths (<i>P</i> = 0.52; 95% CI, -1.07, 1.05), arch... | 42256689 | Revista cientifica odontologica (Universidad Cientifica del Sur) | [
0.6990577578544617,
0.5549798607826233,
0.5779427289962769,
0.5545221567153931,
0.5742211937904358,
0.5636889338493347
] |
Title: Aortic root abscess in a high-risk case requiring modified hemi-UFO procedure with custom-made pericardial conduit - a case report. Background: The UFO procedure is an established surgical technique to treat extensive endocarditis of the aortic or mitral valve with involvement of the intervalvular fibrous body (... | We showed a successful surgical treatment of aortic prosthesis endocarditis with involvement of the IVFB. We were able to perform a radical resection of the infected tissue, reconstruct and replaced all sacrificed tissue with biological tissue and preserved the native mitral valve in a modified hemi-UFO procedure. | There were 467 patients who underwent 686 PVIs (665 SPVI [96.9%] and 21 PPVI [3.1%]). The surgical prostheses were all biologic valved conduits: aortic homograft (118, 17.7%), pulmonary homograft (312, 46.9%) and Contegra (235, 35.3%). The percutaneous prostheses were exclusively Melody valves (21, 100.0%). Incidence o... | The patient recovered from surgery and discharged but died 10 months after surgery because of complete resection was impossible and adjuvant therapy was not performed. Resection of primary cardiac angiosarcomas should be integrated with a combination of chemotherapy, radiotherapy, and targeted therapy based on tumor ce... | Endovascular repair requires suitable anatomy, including adequate landing zones and small neck size, which were lacking here. Direct surgical patch repair offers a safe, effective, and less-invasive alternative to full aortic replacement, especially in septic, frail patients. Multidisciplinary heart team discussion is ... | Cardiac angiosarcomas can be large and challenging to resect. Aggressive surgical resection may prolong survival, even with positive margins. Extensive surgical resection may improve survival for cardiac angiosarcoma with locally extensive and metastatic disease. | In the RG, the early mortality rate was 4.2% (8/192). In the BG, the early mortality rate was 5.1% (16/316). There were no significant differences between groups. The incidence of postoperative renal failure in the BG was significantly higher than that in the RG. The mean follow-up time was 2.93 years (standard deviati... | 42249393 | Journal of cardiothoracic surgery | [
0.7817303538322449,
0.44925129413604736,
0.43282264471054077,
0.5077046155929565,
0.467698872089386,
0.5263789892196655
] |
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PMC Veterinary N-Tuples Dataset
Dataset Description
4,210 n‑tuples of (anchor, positive, 5 hard negatives) extracted from open‑access PubMed Central veterinary papers. Each anchor (title + background/objective) is paired with its own conclusions (positive) and five carefully mined hard negatives from different journals, ensuring no data leakage. The dataset is ready for training bi‑encoder models with MultipleNegativesRankingLoss.
Source Code & Reproducibility
- 💻 GitHub: petVet-dataset-creation-nhci
- 📓 Kaggle: petvet-dataset-creation
Dataset Structure
Each row has:
anchor: string – research context (title + background/objective)positive: string – results/conclusions of the same papernegative_1tonegative_5: strings – hard negatives from other papers, pre‑filtered with PMID‑ and journal‑level maskingid: string – PubMed ID (PMID) of the anchor paperjournal: string – journal name
Mining Statistics (brief)
| Metric | Value |
|---|---|
| Positive mean cosine similarity | 0.70 |
| Negative mean cosine similarity | 0.49 |
| Pos–Neg similarity gap | 0.21 |
| Cross‑journal purity | 100% (no same‑journal negatives) |
Intended Use
Fine‑tuning Sentence‑Transformers for veterinary/biomedical information retrieval. The dataset natively supports MultipleNegativesRankingLoss and can be used directly with the SentenceTransformerTrainer.
Quick Start
from datasets import load_dataset
dataset = load_dataset("dorrito-dev/pmc-vet-ntuples")
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