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9,394 | Hypericum perforatum and Its Ingredients Hypericin and Pseudohypericin Demonstrate an Antiviral Activity against SARS-CoV-2 | For almost two years, the COVID-19 pandemic has constituted a major challenge to human health, particularly due to the lack of efficient antivirals to be used against the virus during routine treatment interventions. Multiple treatment options have been investigated for their potential inhibitory effect on SARS-CoV-2. ... | Pharmaceuticals | Fakry F. Mohamed, Department of Virology, Faculty of Veterinary Medicine, Zagazig University, Zagazig 44511, Sharkia, Egypt& Institute of Virology Muenster, Center for Molecular Biology of Inflammation (ZMBE), University Hospital Muenster, 48149 Muenster, Germany; Darisuren Anhlan, Institute of Virology Muenster, Cente... | Hypericum perforatum and Its Ingredients Hypericin and Pseudohypericin Demonstrate an Antiviral Activity against SARS-CoV-2 For almost two years, the COVID-19 pandemic has constituted a major challenge to human health, particularly due to the lack of efficient antivirals to be used against the virus during routine trea... | Hypericum perforatum and Its Ingredients Hypericin and Pseudohypericin Demonstrate an Antiviral Activity against SARS-CoV-2 For almost two years, the COVID-19 pandemic has constituted a major challenge to human health, particularly due to the lack of efficient antivirals to be used against the virus during routine trea... |
898 | Political Secularism and Muslim Integration in the West: Assessing the Effects of the French Headscarf Ban | In response to rising immigration flows and the fear of Islamic radicalization, several Western countries have enacted policies to restrict religious expression and emphasize secularism and Western values. Despite intense public debate, there is little systematic evidence on how such policies influence the behavior of ... | American Political Science Review | AALA ABDELGADIR, Stanford University; VASILIKI FOUKA, Stanford University | Political Secularism and Muslim Integration in the West: Assessing the Effects of the French Headscarf Ban In response to rising immigration flows and the fear of Islamic radicalization, several Western countries have enacted policies to restrict religious expression and emphasize secularism and Western values. Despite... | Political Secularism and Muslim Integration in the West: Assessing the Effects of the French Headscarf Ban In response to rising immigration flows and the fear of Islamic radicalization, several Western countries have enacted policies to restrict religious expression and emphasize secularism and Western values. Despite... |
2,398 | Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February | The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of death for VOC compared with non-VOC cases in England (hazard ratio: 1.67; 95% confidence interval: 1.3... | Eurosurveillance | Daniel J Grint, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; Kevin Wing, Faculty of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom; Elizabeth Williamson, Faculty of Epidemiology and Popu... | Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of ... | Case fatality risk of the SARS-CoV-2 variant of concern B.1.1.7 in England, 16 November to 5 February The SARS-CoV-2 B.1.1.7 variant of concern (VOC) is increasing in prevalence across Europe. Accurate estimation of disease severity associated with this VOC is critical for pandemic planning. We found increased risk of ... |
5,906 | Realized Volatility Forecasting with Neural Networks | Abstract In the last few decades, a broad strand of literature in finance has implemented artificial neural networks as a forecasting method. The major advantage of this approach is the possibility to approximate any linear and nonlinear behaviors without knowing the structure of the data generating process. This makes... | Journal of Financial Econometrics | Andrea Bucci, Università Politecnica delle Marche& Università degli Studi G. d’Annunzio Chieti e Pescara | Realized Volatility Forecasting with Neural Networks Abstract In the last few decades, a broad strand of literature in finance has implemented artificial neural networks as a forecasting method. The major advantage of this approach is the possibility to approximate any linear and nonlinear behaviors without knowing the... | Realized Volatility Forecasting with Neural Networks Abstract In the last few decades, a broad strand of literature in finance has implemented artificial neural networks as a forecasting method. The major advantage of this approach is the possibility to approximate any linear and nonlinear behaviors without knowing the... |
2,343 | Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials | Evidence on preventing Alzheimer's disease (AD) is challenging to interpret due to varying study designs with heterogeneous endpoints and credibility. We completed a systematic review and meta-analysis of current evidence with prospective designs to propose evidence-based suggestions on AD prevention. Electronic databa... | Journal of Neurology Neurosurgery & Psychiatry | Jin-Tai Yu, Department of Neurology and Institute of Neurology, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai 200040, China; Wei Xu, Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China; Chen-Chen Tan, Department of Neurology, Qingdao Municipal Hospital, Qingd... | Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials Evidence on preventing Alzheimer's disease (AD) is challenging to interpret due to varying study designs with heterogeneous endpoints and credibility. We co... | Evidence-based prevention of Alzheimer's disease: systematic review and meta-analysis of 243 observational prospective studies and 153 randomised controlled trials Evidence on preventing Alzheimer's disease (AD) is challenging to interpret due to varying study designs with heterogeneous endpoints and credibility. We co... |
8,225 | Collaboration, Co-Optation or Navigation? The Role of Civil Society in Disaster Governance in India | Abstract Existing research on civil society organizations (CSOs) facing restricted civic space largely focuses on the crackdown on freedoms and CSOs’ strategies to handle these restrictions, often emphasizing impact on their more confrontational public roles. However, many CSOs shape their roles through collaborative r... | VOLUNTAS International Journal of Voluntary and Nonprofit Organizations | Reetika Syal, Jain Deemed-To-Be University, Bangalore, India; Margit van Wessel, Wageningen University & Research, Hollandseweg 1, 6706 KN, Wageningen, The Netherlands; Sarbeswar Sahoo, Indian Institute of Technology Delhi, New Delhi, India | Collaboration, Co-Optation or Navigation? The Role of Civil Society in Disaster Governance in India Abstract Existing research on civil society organizations (CSOs) facing restricted civic space largely focuses on the crackdown on freedoms and CSOs’ strategies to handle these restrictions, often emphasizing impact on t... | Collaboration, Co-Optation or Navigation? The Role of Civil Society in Disaster Governance in India Abstract Existing research on civil society organizations (CSOs) facing restricted civic space largely focuses on the crackdown on freedoms and CSOs’ strategies to handle these restrictions, often emphasizing impact on t... |
5,506 | Implication of backward contact tracing in the presence of overdispersed transmission in COVID-19 outbreak | Abstract Unlike forward contact tracing, backward contact tracing identifies the source of newly detected cases. This approach is particularly valuable when there is high individual-level variation in the number of secondary transmissions. By using a simple branching process model, we explored the potential of combinin... | medRxiv (Cold Spring Harbor Laboratory) | Akira Endo, Centre for the Mathematical Modelling of Infectious Diseases, London School of Hygiene & Tropical Medicine, London, UK& Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK& The Alan Turing Institute, London, UK; Quentin J Leclerc, Centre for the Mathematic... | Implication of backward contact tracing in the presence of overdispersed transmission in COVID-19 outbreak Abstract Unlike forward contact tracing, backward contact tracing identifies the source of newly detected cases. This approach is particularly valuable when there is high individual-level variation in the number o... | Implication of backward contact tracing in the presence of overdispersed transmission in COVID-19 outbreak Abstract Unlike forward contact tracing, backward contact tracing identifies the source of newly detected cases. This approach is particularly valuable when there is high individual-level variation in the number o... |
6,451 | Army ants dynamically adjust living bridges in response to a cost–benefit trade-off | The ability of individual animals to create functional structures by joining together is rare and confined to the social insects. Army ants (Eciton) form collective assemblages out of their own bodies to perform a variety of functions that benefit the entire colony. Here we examine ‟bridges" of linked individuals that ... | Proceedings of the National Academy of Sciences | Chris R. Reid, Department of Biological Sciences, New Jersey Institute of Technology, Newark, NJ 07102;; Matthew J. Lutz, Department of Ecology and Evolutionary Biology, Princeton University, Princeton, NJ 08544;; Scott Powell, Department of Biological Sciences, George Washington University, Washington, DC 20052;; Albe... | Army ants dynamically adjust living bridges in response to a cost–benefit trade-off The ability of individual animals to create functional structures by joining together is rare and confined to the social insects. Army ants (Eciton) form collective assemblages out of their own bodies to perform a variety of functions t... | Army ants dynamically adjust living bridges in response to a cost–benefit trade-off The ability of individual animals to create functional structures by joining together is rare and confined to the social insects. Army ants (Eciton) form collective assemblages out of their own bodies to perform a variety of functions t... |
2,670 | Words without meaning | Many of the words used by scientists when reviewing manuscripts, job candidates and grant applications – words such as incremental, novelty, mechanism, descriptive and impact – have lost their meaning. | eLife | Eve Marder, Biology Department, Brandeis University, Waltham, United States& Center and the Biology Department, Brandeis University, Waltham, United States. | Words without meaning Many of the words used by scientists when reviewing manuscripts, job candidates and grant applications – words such as incremental, novelty, mechanism, descriptive and impact – have lost their meaning. | Words without meaning Many of the words used by scientists when reviewing manuscripts, job candidates and grant applications – words such as incremental, novelty, mechanism, descriptive and impact – have lost their meaning. |
3,497 | Does Stretching Training Influence Muscular Strength? A Systematic Review With Meta-Analysis and Meta-Regression | Abstract Thomas, E, Ficarra, S, Nunes, JP, Paoli, A, Bellafiore, M, Palma, A, and Bianco, A. Does stretching training influence muscular strength? A systematic review with meta-analysis and meta-regression. J Strength Cond Res 37(5): 1145–1156, 2023—The aim of this study was to review articles that performed stretching... | The Journal of Strength and Conditioning Research | Ewan Thomas, Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo, Italy;; Salvatore Ficarra, Sport and Exercise Sciences Research Unit, Department of Psychology, Educational Science and Human Movement, University of Palermo, Palermo... | Does Stretching Training Influence Muscular Strength? A Systematic Review With Meta-Analysis and Meta-Regression Abstract Thomas, E, Ficarra, S, Nunes, JP, Paoli, A, Bellafiore, M, Palma, A, and Bianco, A. Does stretching training influence muscular strength? A systematic review with meta-analysis and meta-regression. ... | Chronic static stretching programs modestly enhance dynamic muscular strength (ES = 0.33, p = 0.007). Stretching before resistance training sessions for over 8 weeks negatively impacts strength gains (ES = -0.43, p = 0.014). Longer study durations correlate with smaller strength improvements (β = -0.100, p = 0.004). St... |
1,087 | The structure, function and evolution of a complete human chromosome 8 | Abstract The complete assembly of each human chromosome is essential for understanding human biology and evolution 1,2 . Here we use complementary long-read sequencing technologies to complete the linear assembly of human chromosome 8. Our assembly resolves the sequence of five previously long-standing gaps, including ... | Nature | Glennis A. Logsdon, Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA; Mitchell R. Vollger, Department of Genome Sciences, University of Washington School of Medicine, Seattle, WA, USA; PingHsun Hsieh, Department of Genome Sciences, University of Washington School of Medicine,... | The structure, function and evolution of a complete human chromosome 8 Abstract The complete assembly of each human chromosome is essential for understanding human biology and evolution 1,2 . Here we use complementary long-read sequencing technologies to complete the linear assembly of human chromosome 8. Our assembly ... | The structure, function and evolution of a complete human chromosome 8 Abstract The complete assembly of each human chromosome is essential for understanding human biology and evolution 1,2 . Here we use complementary long-read sequencing technologies to complete the linear assembly of human chromosome 8. Our assembly ... |
1,819 | Treatment Emergent Violence To Self And Others; A Literature Review of Neuropsychiatric Adverse Reactions For Antidepressant And Neuroleptic Psychiatric Drugs And General Medications. | This paper reviews the literature linking physical violence, directed towards self or others, to serotonergic and dopaminergic psychiatric drugs and general medications.Data about side effects, pharmacogenetics and homeostasis are obtained from articles, electronic Medicines Compendium, DSM-IV-TR, British National Form... | PubMed | Catherine Clarke; Jan Evans; Kelly Brogan | Treatment Emergent Violence To Self And Others; A Literature Review of Neuropsychiatric Adverse Reactions For Antidepressant And Neuroleptic Psychiatric Drugs And General Medications. This paper reviews the literature linking physical violence, directed towards self or others, to serotonergic and dopaminergic psychiatr... | This literature review examines the link between psychiatric drugs (serotonergic and dopaminergic) and general medications and violence (self-directed or toward others). It highlights pharmacogenetic variations (e.g., CYP450 enzymes, serotonin transporter gene 5-HTTLPR) influencing drug metabolism and neuropsychiatric ... |
2,308 | SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study | AbstractObjective To investigate the association between SARS-CoV-2 vaccination and myocarditis or myopericarditis. Design Population based cohort study. Setting Denmark. Participants 4 931 775 individuals aged 12 years or older, followed from 1 October 2020 to 5 October 2021. Main outcome measures The primary outcome,... | BMJ | Anders Husby, Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark& Department of Epidemiology and Biostatistics, Imperial College London, London, UK; Jørgen Vinsløv Hansen, Department of Epidemiology Research, Statens Serum Institute, Copenhagen, Denmark; Emil Fosbøl, Department of Cardiol... | SARS-CoV-2 vaccination and myocarditis or myopericarditis: population based cohort study AbstractObjective To investigate the association between SARS-CoV-2 vaccination and myocarditis or myopericarditis. Design Population based cohort study. Setting Denmark. Participants 4 931 775 individuals aged 12 years or older, f... | A population-based cohort study in Denmark investigated the association between SARS-CoV-2 mRNA vaccinations (BNT162b2 and mRNA-1273) and myocarditis/myopericarditis. Among 4,931,775 participants aged 12+ years, 269 cases of myocarditis/myopericarditis were recorded. BNT162b2 was associated with a 34% increased risk (H... |
6,084 | Molnupiravir Use and 30-Day Hospitalizations or Death in a Previously Uninfected Nonhospitalized High-risk Population With COVID-19 | Abstract Background Clinical benefit of molnupiravir (MPV) in coronavirus disease 2019 (COVID-19)–infected subpopulations is unclear. Methods We used a matched cohort study design to determine the rate of hospitalization or death within 30 days of COVID-19 diagnosis among MPV treated and untreated controls. Participant... | The Journal of Infectious Diseases | Adeel A Butt, Department of Population Health Sciences, Weill Cornell Medicine , Doha , Qatar& Department of Population Health Sciences, Weill Cornell Medicine , New York, New York , USA& Department of Population Health Sciences, Weill Cornell Medicine, Doha, Qatar& Department of Population Health Sciences, Weill Corne... | Molnupiravir Use and 30-Day Hospitalizations or Death in a Previously Uninfected Nonhospitalized High-risk Population With COVID-19 Abstract Background Clinical benefit of molnupiravir (MPV) in coronavirus disease 2019 (COVID-19)–infected subpopulations is unclear. Methods We used a matched cohort study design to deter... | Molnupiravir Use and 30-Day Hospitalizations or Death in a Previously Uninfected Nonhospitalized High-risk Population With COVID-19 Abstract Background Clinical benefit of molnupiravir (MPV) in coronavirus disease 2019 (COVID-19)–infected subpopulations is unclear. Methods We used a matched cohort study design to deter... |
3,724 | Pediatric Minimal Change Disease and AKI following the Pfizer-BioNTech COVID-19 Vaccine: causal or incidental correlation? | The global coronavirus 2019 (COVID-19) pandemic required vaccination even in children to reduce infection. We report on the development of acute kidney injury (AKI) and minimal change disease (MCD) nephrotic syndrome (NS), shortly after the first injection BNT162b2 COVID-19 vaccine (Pfizer-BioNTech). A 12-year-old prev... | PubMed | Luigi Annicchiarico Petruzzelli, Paediatric Nephrology, Dialysis and Renal Transplantation Santobono Pausilipon Children's Hospital, Naples, Italy.; Bruno Minale, Paediatric Nephrology, Dialysis and Renal Transplantation Santobono Pausilipon Children's Hospital, Naples, Italy.; Vittorio Serio, Paediatric Nephrology, Di... | Pediatric Minimal Change Disease and AKI following the Pfizer-BioNTech COVID-19 Vaccine: causal or incidental correlation? The global coronavirus 2019 (COVID-19) pandemic required vaccination even in children to reduce infection. We report on the development of acute kidney injury (AKI) and minimal change disease (MCD)... | Pediatric Minimal Change Disease and AKI following the Pfizer-BioNTech COVID-19 Vaccine: causal or incidental correlation? The global coronavirus 2019 (COVID-19) pandemic required vaccination even in children to reduce infection. We report on the development of acute kidney injury (AKI) and minimal change disease (MCD)... |
3,184 | Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease | Significance Statement The innate immune system is central to injury and repair in the kidney, but the heterogeneity of myeloid cell subsets behind these processes is unknown. Complementary technologies—including bulk tissue transcriptomics, integrated droplet– and plate-based single-cell RNA sequencing, and paired blo... | Journal of the American Society of Nephrology | Bryan R. Conway, Centre for Cardiovascular Science, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; Eoin D. O’Sullivan, Medical Research Council Centre for Inflammation Research, Queen's Medical Research Institute, University of Edinburgh, Edinburgh, United Kingdom; Carolynn Cair... | Kidney Single-Cell Atlas Reveals Myeloid Heterogeneity in Progression and Regression of Kidney Disease Significance Statement The innate immune system is central to injury and repair in the kidney, but the heterogeneity of myeloid cell subsets behind these processes is unknown. Complementary technologies—including bulk... | The study used single-cell RNA sequencing to create a kidney single-cell atlas in a mouse model of kidney disease. It revealed 12 novel myeloid cell subsets involved in kidney injury and repair, including Arg1+ monocytes during injury and Mmp12+ macrophages during repair, which conventional flow cytometry would miss. T... |
6,387 | The role of social circle COVID-19 illness and vaccination experiences in COVID-19 vaccination decisions: an online survey of the United States population | Abstract Background Around the world, policymakers have clearly communicated that COVID-19 vaccination programs need to be accepted by a large proportion of the population to allow life return to normal. However, according to the Center for Disease Control, about 31% of the United States population had not completed th... | BMC Infectious Diseases | Mark Skidmore, Department of Agricultural, Food and Resource Economics, Department of Economics, Michigan State University, 91 Morrill Hall of Agriculture, East Lansing, MI, 48824-1039, USA | The role of social circle COVID-19 illness and vaccination experiences in COVID-19 vaccination decisions: an online survey of the United States population Abstract Background Around the world, policymakers have clearly communicated that COVID-19 vaccination programs need to be accepted by a large proportion of the popu... | An online survey of 2840 U.S. adults found that knowing someone affected by COVID-19 illness increased vaccine uptake (OR: 1.309), while knowing someone affected by vaccination decreased it (OR: 0.567). 34% knew someone with severe COVID-19 effects, 22% with severe vaccination effects. Estimated potential vaccine-relat... |
3,728 | A Survey and Analysis of TLS Interception Mechanisms and Motivations: Exploring how end-to-end TLS is made “end-to-me” for web traffic | TLS is an end-to-end protocol designed to provide confidentiality and integrity guarantees that improve end-user security and privacy. While TLS helps defend against pervasive surveillance of intercepted unencrypted traffic, it also hinders several common beneficial operations typically performed by middleboxes on the ... | ACM Computing Surveys | Xavier de Carné de Carnavalet, The Hong Kong Polytechnic University, Hong Kong SAR; Paul C. van Oorschot, Carleton University, Ontario, Canada | A Survey and Analysis of TLS Interception Mechanisms and Motivations: Exploring how end-to-end TLS is made “end-to-me” for web traffic TLS is an end-to-end protocol designed to provide confidentiality and integrity guarantees that improve end-user security and privacy. While TLS helps defend against pervasive surveilla... | A Survey and Analysis of TLS Interception Mechanisms and Motivations: Exploring how end-to-end TLS is made “end-to-me” for web traffic TLS is an end-to-end protocol designed to provide confidentiality and integrity guarantees that improve end-user security and privacy. While TLS helps defend against pervasive surveilla... |
2,702 | SARS-CoV-2 RNA levels in Scotland’s wastewater | Abstract Nationwide, wastewater-based monitoring was newly established in Scotland to track the levels of SARS-CoV-2 viral RNA shed into the sewage network, during the COVID-19 pandemic. We present a curated, reference data set produced by this national programme, from May 2020 to February 2022. Viral levels were analy... | medRxiv (Cold Spring Harbor Laboratory) | Livia C. T. Scorza, SynthSys and School of Biological Sciences, University of Edinburgh, Edinburgh EH9 3JD, UK; Graeme J. Cameron, Scottish Environment Protection Agency (SEPA), Strathallan House, Stirling FK9 4TZ, UK; Roisin Murray-Williams, Scottish Environment Protection Agency (SEPA), Strathallan House, Stirling FK... | SARS-CoV-2 RNA levels in Scotland’s wastewater Abstract Nationwide, wastewater-based monitoring was newly established in Scotland to track the levels of SARS-CoV-2 viral RNA shed into the sewage network, during the COVID-19 pandemic. We present a curated, reference data set produced by this national programme, from May... | SARS-CoV-2 RNA levels in Scotland’s wastewater Abstract Nationwide, wastewater-based monitoring was newly established in Scotland to track the levels of SARS-CoV-2 viral RNA shed into the sewage network, during the COVID-19 pandemic. We present a curated, reference data set produced by this national programme, from May... |
7,883 | Black Lives Matter's Effect on Police Lethal Use-of-Force | How has Black Lives Matter (BLM) influenced police lethal force? An event study design finds census places with early BLM protests experienced a 10% to 15% decrease in police homicides from 2014 through 2019, around 200 fewer deaths. This decrease was prominent when protests were large and frequent. Potential mechanism... | SSRN Electronic Journal | Travis Campbell, Southern Oregon University | Black Lives Matter's Effect on Police Lethal Use-of-Force How has Black Lives Matter (BLM) influenced police lethal force? An event study design finds census places with early BLM protests experienced a 10% to 15% decrease in police homicides from 2014 through 2019, around 200 fewer deaths. This decrease was prominent ... | Black Lives Matter's Effect on Police Lethal Use-of-Force How has Black Lives Matter (BLM) influenced police lethal force? An event study design finds census places with early BLM protests experienced a 10% to 15% decrease in police homicides from 2014 through 2019, around 200 fewer deaths. This decrease was prominent ... |
2,930 | The newly introduced SARS-CoV-2 variant A222V is rapidly spreading in Lazio region, Italy | Abstract A new SARS-CoV-2 clade (GV) characterized by S substitution A222V, first reported from Spain in March, is rapidly spreading across Europe. To establish the A222V variant involvement in the infection rise in Italy, all GISAID sequences from Italy and those from our Laboratory (Lazio) in the period June-October ... | medRxiv (Cold Spring Harbor Laboratory) | Barbara Bartolini, National Institute for Infectious Diseases, INMI, "Lazzaro Spallanzani" IRCCS, Rome, Italy; Martina Rueca, National Institute for Infectious Diseases, INMI, "Lazzaro Spallanzani" IRCCS, Rome, Italy; Cesare Ernesto Maria Gruber, National Institute for Infectious Diseases, INMI, "Lazzaro Spallanzani" I... | The newly introduced SARS-CoV-2 variant A222V is rapidly spreading in Lazio region, Italy Abstract A new SARS-CoV-2 clade (GV) characterized by S substitution A222V, first reported from Spain in March, is rapidly spreading across Europe. To establish the A222V variant involvement in the infection rise in Italy, all GIS... | The newly introduced SARS-CoV-2 variant A222V is rapidly spreading in Lazio region, Italy Abstract A new SARS-CoV-2 clade (GV) characterized by S substitution A222V, first reported from Spain in March, is rapidly spreading across Europe. To establish the A222V variant involvement in the infection rise in Italy, all GIS... |
5,988 | Super high-pressure balloon versus scoring balloon to prepare severely calcified coronary lesions: the ISAR-CALC randomised trial | The comparative efficacy of balloon-based techniques to prepare severely calcified coronary lesions before stenting remains poorly studied.We sought to compare stent expansion following preparation of severely calcified coronary lesions with either a super high-pressure balloon or a scoring balloon.In this randomised, ... | EuroIntervention | Tobias Rheude, Klinik für Herz- und Kreislauferkrankungen, Deutsches Herzzentrum München, Munich, Germany.; Himanshu Rai; Gert Richardt; Abdelhakim Allali; Mohamed Abdel-Wahab; Dmitriy S Sulimov; Kambis Mashayekhi; Mohamed Ayoub; Florim Cuculi; Matthias Bossard; Sebastian Kufner; Erion Xhepa; Adnan Kastrati; Massimilia... | Super high-pressure balloon versus scoring balloon to prepare severely calcified coronary lesions: the ISAR-CALC randomised trial The comparative efficacy of balloon-based techniques to prepare severely calcified coronary lesions before stenting remains poorly studied.We sought to compare stent expansion following prep... | The ISAR-CALC trial compared super high-pressure balloons and scoring balloons for preparing severely calcified coronary lesions. Both methods achieved similar stent expansion indices. Super high-pressure balloons showed trends toward larger minimum lumen diameters and reduced diameter stenosis, with no significant dif... |
4,890 | The UK government’s covid complacency shows lessons haven’t been learned | This week, England’s health secretary, Sajid Javid told a Downing Street covid briefing that the government would not “at this point” be implementing its so-called “Plan B” measures to prevent the NHS being overwhelmed—including mandatory face coverings indoors and advising people to work from home.
To repurpose a phr... | BMJ | Gareth Iacobucci, The BMJ | The UK government’s covid complacency shows lessons haven’t been learned This week, England’s health secretary, Sajid Javid told a Downing Street covid briefing that the government would not “at this point” be implementing its so-called “Plan B” measures to prevent the NHS being overwhelmed—including mandatory face cov... | The UK government’s covid complacency shows lessons haven’t been learned This week, England’s health secretary, Sajid Javid told a Downing Street covid briefing that the government would not “at this point” be implementing its so-called “Plan B” measures to prevent the NHS being overwhelmed—including mandatory face cov... |
6,718 | SARS-CoV-2 Infections and Serologic Responses from a Sample of U.S. Navy Service Members — USS Theodore Roosevelt, April 2020 | Compared with the volume of data on coronavirus disease 2019 (COVID-19) outbreaks among older adults, relatively few data are available concerning COVID-19 in younger, healthy persons in the United States (1,2). In late March 2020, the aircraft carrier USS Theodore Roosevelt arrived at port in Guam after numerous U.S. ... | MMWR Morbidity and Mortality Weekly Report | Daniel C. Payne; Sarah E. Smith-Jeffcoat; Gosia Nowak; Uzo Chukwuma; Jesse R. Geibe; Robert J. Hawkins; Jeffrey A. Johnson; Natalie J. Thornburg; Jarad Schiffer; Zachary Weiner; Bettina Bankamp; Michael D. Bowen; Adam MacNeil; Monita R. Patel; Eric Deussing; Bruce L. Gillingham; Rebekah Tiller; Rene Galloway; Shannon R... | SARS-CoV-2 Infections and Serologic Responses from a Sample of U.S. Navy Service Members — USS Theodore Roosevelt, April 2020 Compared with the volume of data on coronavirus disease 2019 (COVID-19) outbreaks among older adults, relatively few data are available concerning COVID-19 in younger, healthy persons in the Uni... | SARS-CoV-2 Infections and Serologic Responses from a Sample of U.S. Navy Service Members — USS Theodore Roosevelt, April 2020 Compared with the volume of data on coronavirus disease 2019 (COVID-19) outbreaks among older adults, relatively few data are available concerning COVID-19 in younger, healthy persons in the Uni... |
5,423 | New-Onset Systemic Lupus Erythematosus after mRNA SARS-CoV-2 Vaccination | Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease resulting from the interaction of genetic and environmental factors. In addition, some antiviral vaccines have been associated with the onset of SLE. Few cases of SLE occurring after SARS-CoV-2 mRNA have been reported. Herein, we report the case of ... | Case Reports in Rheumatology | Laisha Báez-Negrón, Division of Rheumatology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico; Luis M. Vilá, Division of Rheumatology, University of Puerto Rico, Medical Sciences Campus, San Juan, Puerto Rico | New-Onset Systemic Lupus Erythematosus after mRNA SARS-CoV-2 Vaccination Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease resulting from the interaction of genetic and environmental factors. In addition, some antiviral vaccines have been associated with the onset of SLE. Few cases of SLE occurring... | New-Onset Systemic Lupus Erythematosus after mRNA SARS-CoV-2 Vaccination Systemic lupus erythematosus (SLE) is a multisystem autoimmune disease resulting from the interaction of genetic and environmental factors. In addition, some antiviral vaccines have been associated with the onset of SLE. Few cases of SLE occurring... |
3,213 | A Sustainable and Global Health Perspective of the Dietary Pattern of French Population during the 1998–2015 Period from INCA Surveys | In France, the evolution of dietary pattern relative to sustainability and global health remains insufficiently studied. The objective of this study was to assess dietary changes during 1998–2015 through three generic metrics potentially related to sustainability. Food consumption data were collected from three French ... | Sustainability | Anthony Fardet, Unité de Nutrition Humaine& Université Clermont Auvergne; David Thivel, Laboratoire des Adaptations Métaboliques à l'Exercice en Conditions Physiologiques et Pathologiques; Laurent Gerbaud, CHU Clermont-Ferrand& Institut Pascal; Edmond Rock, Unité de Nutrition Humaine& Université Clermont Auvergne | A Sustainable and Global Health Perspective of the Dietary Pattern of French Population during the 1998–2015 Period from INCA Surveys In France, the evolution of dietary pattern relative to sustainability and global health remains insufficiently studied. The objective of this study was to assess dietary changes during ... | A Sustainable and Global Health Perspective of the Dietary Pattern of French Population during the 1998–2015 Period from INCA Surveys In France, the evolution of dietary pattern relative to sustainability and global health remains insufficiently studied. The objective of this study was to assess dietary changes during ... |
3,017 | Association of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock | Acute myocardial infarction (AMI) complicated by cardiogenic shock is associated with substantial morbidity and mortality. Although intravascular microaxial left ventricular assist devices (LVADs) provide greater hemodynamic support as compared with intra-aortic balloon pumps (IABPs), little is known about clinical out... | JAMA | Sanket S. Dhruva, Section of Cardiology, Department of Medicine, San Francisco Veterans Affairs Medical Center, San Francisco, California& University of California, San Francisco School of Medicine, San Francisco; Joseph S. Ross, Center for Outcomes Research and Evaluation, Yale-New Haven Hospital, New Haven, Connectic... | Association of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock Acute myocardial infarction (AMI) complicated by cardiogenic shock is associated wi... | In-hospital mortality and major bleeding were higher among patients with acute myocardial infarction (AMI) and cardiogenic shock who received an intravascular microaxial left ventricular assist device (LVAD) compared to those who received an intra-aortic balloon pump (IABP). A retrospective cohort study of 1,680 propen... |
382 | Fluvoxamine for outpatients with COVID-19: where do we stand? | Advances in vaccine development have had a major effect on reducing the number of new symptomatic cases, hospitalisations, and deaths due to COVID-19, the viral disease caused by SARS-CoV-2, globally.1Tregoning JS Flight KE Higham SL Wang Z Pierce BF Progress of the COVID-19 vaccine effort: viruses, vaccines and varian... | The Lancet Global Health | Otavio Berwanger, Academic Research Organization (ARO), Hospital Israelita Albert Einstein, Sao Paulo-SP, Brazil | Fluvoxamine for outpatients with COVID-19: where do we stand? Advances in vaccine development have had a major effect on reducing the number of new symptomatic cases, hospitalisations, and deaths due to COVID-19, the viral disease caused by SARS-CoV-2, globally.1Tregoning JS Flight KE Higham SL Wang Z Pierce BF Progres... | The TOGETHER trial evaluated fluvoxamine's efficacy in reducing the risk of emergency care or hospitalization in high-risk outpatients with early COVID-19. Fluvoxamine (100 mg twice daily for 10 days) reduced the primary endpoint (11% vs. 16%) with a relative risk of 0.68 (95% Bayesian credible interval 0.52–0.88). The... |
4,237 | COVID-19 vaccines dampen genomic diversity of SARS-CoV-2: Unvaccinated patients exhibit more antigenic mutational variance | Abstract Variants of SARS-CoV-2 are evolving under a combination of immune selective pressure in infected hosts and natural genetic drift, raising a global alarm regarding the durability of COVID-19 vaccines. Here, we conducted longitudinal analysis over 1.8 million SARS-CoV-2 genomes from 183 countries or territories ... | medRxiv (Cold Spring Harbor Laboratory) | Michiel J.M. Niesen, nference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 0242, USA; Praveen Anand, nference Labs, Bengaluru, Karnataka, India; Eli Silvert, nference, inc., One Main Street, Suite 400, East Arcade, Cambridge, MA 0242, USA; Rohit Suratekar, nference Labs, Bengaluru, Karnataka, India; Co... | COVID-19 vaccines dampen genomic diversity of SARS-CoV-2: Unvaccinated patients exhibit more antigenic mutational variance Abstract Variants of SARS-CoV-2 are evolving under a combination of immune selective pressure in infected hosts and natural genetic drift, raising a global alarm regarding the durability of COVID-1... | COVID-19 vaccines reduce SARS-CoV-2 genomic diversity and antigenic variability. Longitudinal analysis of 1.8 million genomes from 183 countries showed decreased viral diversity correlated with higher vaccination rates. Vaccinated "breakthrough" cases had lower diversity in B-cell epitopes compared to unvaccinated case... |
4,721 | Paleoeconomy more than demography determined prehistoric human impact in Arctic Norway | Population size has increasingly been taken as the driver of past human environmental impact worldwide, and particularly in the Arctic. However, sedimentary ancient DNA (sedaDNA), pollen and archaeological data show that over the last 12,000 years, paleoeconomy and culture determined human impacts on the terrestrial ec... | PNAS Nexus | Tony Brown, The Arctic University Museum of Norway, UiT, The Arctic University of Norway , N-9037 Tromsø , Norway; Dilli P Rijal, The Arctic University Museum of Norway, UiT, The Arctic University of Norway , N-9037 Tromsø , Norway; Peter D Heintzman, The Arctic University Museum of Norway, UiT, The Arctic University o... | Paleoeconomy more than demography determined prehistoric human impact in Arctic Norway Population size has increasingly been taken as the driver of past human environmental impact worldwide, and particularly in the Arctic. However, sedimentary ancient DNA (sedaDNA), pollen and archaeological data show that over the las... | Paleoeconomy more than demography determined prehistoric human impact in Arctic Norway Population size has increasingly been taken as the driver of past human environmental impact worldwide, and particularly in the Arctic. However, sedimentary ancient DNA (sedaDNA), pollen and archaeological data show that over the las... |
9,547 | Patrimonialisations de la littérature | Parmi les domaines caractérisés par une charge patrimoniale forte, la littérature continue d’occuper une position de premier plan dans les sociétés contemporaines. Si nous connaissons la littérature du passé et lui accordons une valeur, c’est en effet dans une large mesure parce qu’elle fait l’objet de processus de pat... | Culture & Musées | Marcela Scibiorska; Mathilde Labbé, Littératures antiques et modernes; David Martens | Patrimonialisations de la littérature Parmi les domaines caractérisés par une charge patrimoniale forte, la littérature continue d’occuper une position de premier plan dans les sociétés contemporaines. Si nous connaissons la littérature du passé et lui accordons une valeur, c’est en effet dans une large mesure parce qu... | Literature retains a prominent position in contemporary society due to its patrimonialization processes, which endow it with specific value and functions. These processes involve articulations between historical knowledge and the affective engagement with a past made present and legitimate. This issue aims to identify ... |
9,477 | Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants | ABSTRACT The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has led to growing concerns over increased transmissibility and the ability of some variants to partially escape immunity. Sera from participants immunized on a prime-boost schedule with the mRNA-1273 COVID-19 vaccine were t... | bioRxiv (Cold Spring Harbor Laboratory) | Angela Choi, Moderna Inc., 200 Technology Square, Cambridge, Massachusetts, 0239, USA; Matthew Koch, Moderna Inc., 200 Technology Square, Cambridge, Massachusetts, 0239, USA; Kai Wu, Moderna Inc., 200 Technology Square, Cambridge, Massachusetts, 0239, USA; Groves Dixon, Moderna Inc., 200 Technology Square, Cambridge, M... | Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants ABSTRACT The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has led to growing concerns over increased transmissibility and the ability of some variants to partially escape immunity. Sera from participants immunized... | Serum Neutralizing Activity of mRNA-1273 against SARS-CoV-2 Variants ABSTRACT The emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants has led to growing concerns over increased transmissibility and the ability of some variants to partially escape immunity. Sera from participants immunized... |
4,795 | Multisystem Inflammatory Syndrome in Children in the United States | 23 issue) present case series of the multisystem inflammatory syndrome in children (MIS-C; also called the pediatric inflammatory multisystem syndrome); Levin 3 provides commentary.To address the burden of MIS-C in France, a nationwide surveillance program was launched on April 30, 2020, by Santé Publique France (the F... | New England Journal of Medicine | Leora R Feldstein, Centers for Disease Control and Prevention, Atlanta, GA.; Erica B Rose, Centers for Disease Control and Prevention, Atlanta, GA.; Adrienne G Randolph, Boston Children's Hospital, Boston, MA adrienne.randolph@childrens.harvard.edu. | Multisystem Inflammatory Syndrome in Children in the United States 23 issue) present case series of the multisystem inflammatory syndrome in children (MIS-C; also called the pediatric inflammatory multisystem syndrome); Levin 3 provides commentary.To address the burden of MIS-C in France, a nationwide surveillance prog... | Multisystem Inflammatory Syndrome in Children in the United States 23 issue) present case series of the multisystem inflammatory syndrome in children (MIS-C; also called the pediatric inflammatory multisystem syndrome); Levin 3 provides commentary.To address the burden of MIS-C in France, a nationwide surveillance prog... |
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