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### FUNCTION Alpha-conotoxins bind to the nicotinic acetylcholine receptors Binds to rat alpha-6/alpha-3-beta-2-beta-3 more rapidly than to alpha-3-beta-2, and dissociates more rapidly from alpha-3-beta-2 than from alpha-6/alpha-3-beta-2-beta-3 ### SEQUENCE -P-D-G-R-N-A-A-A-K-A-F-D-L-I-T-P-T-V-R-K-G-C-C-S-N-P-A-C-I-L-N-N-P-N-Q-C-G |
### FUNCTION May produce in vitro relaxation of rat arterial smooth muscle and constriction of intestinal smooth muscle May target bradykinin receptors ### SEQUENCE -M-A-F-L-K-K-S-L-F-L-V-L-F-L-G-V-V-S-L-S-F-C-E-E-E-K-R-E-E-H-E-E-E-K-R-D-E-E-D-A-E-S-L-G-K-R-Y-G-G-L-S-P-L-R-I-S-K-R-V-P-P-G-F-T-P-F-R-S-P-A-R-S-I-S-G-L-T-P-I-R-L-S-K-R-V-P-P-G-F-T-P-F-R-S-P-A-R-R-I-S-E-A-D-P-G-F-T-P-S-F-V-V-I-K-G-L-S-P-L-R-G-K-R-R-P-P-G-F-S-P-F-R-V-D |
### FUNCTION Antimicrobial peptide that acts against Gram-positive bacteria ### SEQUENCE -M-K-L-S-T-S-L-L-A-I-V-A-V-A-S-T-F-I-G-N-A-L-S-A-T-T-V-P-G-C-F-A-E-C-I-D-K-A-A-V-A-V-N-C-A-A-G-D-I-D-C-L-Q-A-S-S-Q-F-A-T-I-V-S-E-C-V-A-T-S-D-C-T-A-L-S-P-G-S-A-S-D-A-D-S-I-N-K-T-F-N-I-L-S-G-L-G-F-I-D-E-A-D-A-F-S-A-A-D-V-P-E-E-R-D-L-T-G-L-G-R-V-L-P-V-E-K-R-Q-N-C-P-T-R-R-G-L-C-V-T-S-G-L-T-A-C-R-N-H-C-R-S-C-H-R-G-D-V-G-C-V-R-C-S-N-A-Q-C-T-G-F-L-G-T-T-C-T-C-I-N-P-C-P-R-C |
### FUNCTION Possibly has a role in RNA transcription or processing during stress which regulate growth and development, as well as responses to environmental inputs, including pathogen attack ### SEQUENCE -M-A-S-S-S-V-E-F-R-C-F-V-G-G-L-A-W-A-T-D-S-N-S-L-E-K-A-F-S-V-Y-G-E-I-V-E-A-K-I-V-S-D-R-E-T-G-R-S-R-G-F-G-F-V-T-F-L-E-E-E-A-M-R-S-A-I-E-A-M-N-G-H-I-L-D-G-R-N-I-T-V-N-E-A-Q-Q-R-G-G-G-G-G-G-G-Y-N-R-G-G-G-Y-G-G-R-R-D-G-G-G-F-S-R-G-G-G-G-G-Y-G-G-G-G-G-G-G-Y-G-G-G-R-D-R-G-Y-G-G-G-G-G-Y-G-G-G-R-D-S-R-G-S-G-G-G-G-S-E-G-G-W-R-N |
### FUNCTION Has antimicrobial activity against the Gram-positive bacteria Saureus ### SEQUENCE -M-E-I-K-Y-L-L-T-V-F-L-V-L-L-I-V-S-D-H-C-Q-A-F-L-F-S-L-I-P-H-A-I-S-G-L-I-S-A-F-K-G-R-R-K-R-D-L-D-G-Q-I-D-R-F-R-N-F-R-K-R-D-A-E-L-E-E-L-L-S-K-L-P-I-Y |
### FUNCTION Has antimicrobial activity against the Gram-positive bacteria Saureus ### SEQUENCE -M-E-I-K-Y-L-L-T-V-F-L-V-L-L-I-V-S-D-H-C-Q-A-F-L-F-S-L-I-P-N-A-I-S-G-L-L-S-A-F-K-G-R-R-K-R-N-L-D-G-Q-I-D-R-F-R-N-F-R-K-R-D-A-E-L-E-E-L-L-S-K-L-P-I-Y |
### FUNCTION Toxic component of a type VII toxin-antitoxin system Upon cloning in Ecoli inhibits cell growth for several hours ### SEQUENCE -M-T-N-I-E-P-V-I-I-E-T-R-L-E-L-I-G-R-Y-L-D-H-L-K-K-F-E-N-I-S-L-D-D-Y-L-S-S-F-E-Q-Q-L-I-T-E-R-L-L-Q-L-I-T-Q-A-A-I-D-I-N-D-H-I-L-S-K-L-K-S-G-K-S-Y-T-N-F-E-A-F-I-E-L-G-K-Y-Q-I-L-T-P-E-L-A-K-Q-I-A-P-S-S-G-L-R-N-R-L-V-H-E-Y-D-D-I-D-P-N-Q-V-F-M-A-I-S-F-A-L-Q-Q-Y-P-L-Y-V-R-Q-I-N-S-Y-L-I-T-L-E-E-E-N-D |
### FUNCTION Highly cationic protein that has multiple functions Acts as a chemotactic factor that mediates lymphocytes recruitment to epithelia through binding and activation of the G-protein coupled receptor GPR15 May be a tumor suppressor ### SEQUENCE -M-R-L-L-A-L-S-G-L-L-C-M-L-L-L-C-F-C-I-F-S-S-E-G-R-R-H-P-A-K-S-L-K-L-R-R-C-C-H-L-S-P-R-S-K-L-T-T-W-K-G-N-H-T-R-P-C-R-L-C-R-N-K-L-P-V-K-S-W-V-V-P-G-A-L-P-Q-I |
### FUNCTION Plays a role in regulation of the unfolded protein response triggered by endoplasmic reticulum stress resulting from the presence of unfolded proteins in the ER lumen ### SEQUENCE -M-F-R-R-L-T-F-A-Q-L-L-F-A-T-V-L-G-I-A-G-G-V-Y-I-F-Q-P-V-F-E-Q-Y-A-K-D-Q-K-E-L-K-E-K-M-Q-L-V-Q-E-S-E-E-K-K-S |
### FUNCTION This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock ### SEQUENCE -M-T-T-S-F-Y-F-L-L-V-A-L-G-L-L-L-Y-V-C-Q-S-S-F-G-N-Q-H-T-R-N-S-D-T-P-K-H-R-C-G-S-E-L-A-D-Q-Y-V-Q-L-C-H-G-K-R-N-D-A-G-K-K-R-G-R-A-S-P-L-W-Q-R-Q-G-F-L-S-M-L-K-A-K-R-N-E-A-F-F-L-Q-R-D-G-R-G-I-V-E-V-C-C-D-N-P-C-T-V-A-T-L-R-T-F-C-H |
### FUNCTION This venom insulin, from a fish-hunting cone snail, facilitates prey capture by rapidly inducing hypoglycemic shock ### SEQUENCE -M-T-T-S-S-Y-F-L-L-M-A-L-G-L-L-L-Y-V-C-Q-S-S-F-G-N-Q-H-T-R-T-F-D-T-P-K-H-R-C-G-S-E-I-T-N-S-Y-M-D-L-C-Y-R-K-R-N-D-A-G-E-K-R-G-R-A-S-P-L-W-Q-R-R-G-S-L-S-K-L-K-A-R-A-K-R-N-G-A-F-H-L-P-R-D-G-R-G-V-V-E-H-C-C-H-R-P-C-S-N-A-E-F-K-K-Y-C-G |
### FUNCTION Regulates insulin sensitivity and metabolic homeostasis ### SEQUENCE -M-R-W-Q-E-M-G-Y-I-F-Y-P-R-K-L-R |
### FUNCTION Toxic component of a type II toxin-antitoxin system Expression in Ecoli inhibits cell growth ### SEQUENCE -M-T-T-S-F-W-R-I-A-T-D-A-R-T-Y-E-A-D-D-L-S-G-A-G-A-K-I-T-G-G-R-W-N-E-V-G-V-A-I-V-Y-A-A-S-S-R-A-L-A-C-L-E-T-V-V-H-L-N-S-G-G-L-P-L-N-R-Y-L-V-E-I-E-V-P-D-E-V-L-A-S-A-E-V-A-T-P-G-N-L-P-V-G-W-D-A-E-P-A-G-R-V-S-I-S-F-G-S-Q-W-A-Q-S-Q-R-T-A-L-L-L-V-P-S-V-I-V-P-E-E-T-N-L-L-I-N-P-A-H-P-D-A-K-G-I-K-A-R-K-V-R-K-W-L-Y-D-P-R-M-I-R-K-A |
### FUNCTION Cargo protein of a type 1 encapsulin nanocompartment A ferritin-like iron-binding protein probably involved in iron mineralization in the encapsulin nanocompartment Has ferroxidase activity even when encapsulated, the rate is probably controlled by the rate of Fe flux across the nanocompartment pores ### SEQUENCE -M-K-E-E-L-D-A-F-H-Q-I-F-T-T-T-K-E-A-I-E-R-F-M-A-M-L-T-P-V-I-E-N-A-E-D-D-H-E-R-L-Y-Y-H-H-I-Y-E-E-E-E-Q-R-L-S-R-L-D-V-L-I-P-L-I-E-K-F-Q-D-E-T-D-E-G-L-F-S-P-S-N-N-A-F-N-R-L-L-Q-E-L-N-L-E-K-F-G-L-H-N-F-I-E-H-V-D-L-A-L-F-S-F-T-D-E-E-R-Q-T-L-L-K-E-L-R-K-D-A-Y-E-G-Y-Q-Y-V-K-E-K-L-A-E-I-N-A-R-F-D-H-D-Y-A-D-P-H-A-H-H-D-E-H-R-D-H-L-A-D-M-P-S-A-G-S-S-H-E-E-V-Q-P-V-A-H-K-K-K-G-F-T-V-G-S-L-I-Q |
### FUNCTION D-galactose-binding lectin ### SEQUENCE -M-T-T-F-L-I-K-H-K-A-S-G-K-Y-F-H-P-K-G-G-T-S-N-P-P-N-G-T-N-L-V-L-H-S-D-I-H-E-R-M-Y-F-Q-F-E-V-V-N-E-R-W-R-Y-I-K-H-V-A-S-E-K-I-V-H-P-F-G-G-K-A-D-P-L-N-G-T-N-M-V-L-H-Q-D-R-H-D-R-A-L-F-A-M-D-F-F-N-D-N-I-R-H-K-G-G-K-Y-I-H-P-K-G-G-S-K-N-P-S-N-G-N-L-T-V-M-H-G-D-E-H-G-A-M-E-F-I-F-V-S-P-K-N-K-D-K-R-V-L-V-Y-A |
### FUNCTION Lipid transport protein in adipocytes Binds both long chain fatty acids and retinoic acid Delivers long-chain fatty acids and retinoic acid to their cognate receptors in the nucleus ### SEQUENCE -M-C-D-Q-F-V-G-T-W-K-F-L-S-S-E-N-F-E-D-Y-M-K-E-L-G-V-G-F-A-T-R-K-M-A-G-V-A-K-P-N-V-T-I-S-I-N-G-D-V-I-T-I-K-T-E-S-T-F-K-N-T-E-V-S-F-R-L-G-E-E-F-D-E-T-T-A-D-D-R-K-T-K-N-V-I-T-L-D-N-G-I-L-N-Q-V-Q-K-W-D-G-K-E-T-V-I-K-R-K-V-M-D-G-N-L-V-V-E-C-T-M-N-T-V-T-S-K-R-V-Y-E-R-A |
### FUNCTION Serine protease inhibitor which exhibits antifibrinolytic, antielastolytic and antimicrobial activities ### SEQUENCE -M-R-F-Q-V-Y-I-L-H-L-C-F-F-I-L-V-V-L-T-Y-L-S-Q-G-Q-S-Y-T-T-T-T-T-T-S-T-T-E-Q-P-T-F-L-Q-K-I-H-E-T-F-K-K-V-K-E-N-A-K-I-H-N-L-Y-I-F-D-P-P-T-W-I-Y-T-T-T-T-E-K-P-V-E-S-T-E-N-F-D-I-T-N-R-Q-L-I-T-V-P-V-R-C-P-P-N-Y-D-F-I-K-G-R-C-R-E-K-I-P |
### FUNCTION Extremely potent agonist and potentiator of TRPV1 ### SEQUENCE -M-L-K-S-F-C-I-L-S-V-F-M-V-L-F-L-A-K-F-P-D-L-C-S-G-E-E-I-S-P-L-K-I-V-V-R-N-S-E-Y-L-N-N-P-C-N-G-V-T-C-P-S-G-Y-R-C-S-I-V-D-K-Q-C-I-K-K-E-K |
### FUNCTION Homophilic transmembrane adhesion molecule involved in various processes such as inflammation, cell death, axonal growth, cell chemotaxis and angiogenesis ### SEQUENCE -M-A-S-E-A-M-E-L-N-G-G-V-N-R-R-D-D-P-G-A-R-P-Q-Q-G-R-M-S-R-N-T-P-L-N-M-N-H-Y-A-N-K-K-S-A-A-E-S-M-L-D-I-A-L-L-M-A-N-A-S-Q-L-K-T-V-L-E-L-G-P-S-F-S-F-Y-I-P-L-I-T-L-I-S-I-S-L-T-L-Q-I-I-V-G-I-L-L-I-F-I-V-K-W-N-L-N-D-S-S-K-H-Y-I-L-N-L-L-E-N-I-V-T-A-L-V-F-I-V-V-V-V-N-V-F-I-T-A-F-G-V-Q-R-P-D-D-K-T-S |
### FUNCTION Exhibits both phospholipase A1/2 and acyltransferase activities Shows phospholipase A1 ### SEQUENCE -M-D-N-Q-Q-R-R-T-D-N-M-A-S-G-E-T-D-H-L-Q-C-V-E-E-P-Q-P-G-D-L-I-E-I-F-R-P-A-Y-Q-H-W-A-L-Y-L-G-D-G-Y-I-I-N-L-T-P-V-D-E-G-Q-A-T-A-V-S-S-V-K-S-V-F-S-R-K-A-V-V-R-M-Q-L-L-K-E-V-V-G-A-D-S-Y-R-I-N-N-K-Y-D-D-D-H-T-P-L-P-V-S-E-I-I-Q-R-A-Q-M-L-I-G-Q-E-V-S-Y-D-L-L-G-S-N-C-E-H-F-V-T-L-L-R-Y-G-E-G-V-S-E-Q-A-S-R-A-I-G-A-I-S-L-V-T-A-A-A-S-A-F-S-V-L-G-L-I-N-T-R-S-R-N-R-P-F |
### FUNCTION Promotes dispersal of P-body components and is likely to play a role in the mRNA decapping process ### SEQUENCE -M-G-D-Q-P-C-A-S-G-R-S-T-L-P-P-G-N-A-R-E-A-K-P-P-K-K-R-C-L-L-A-P-R-W-D-Y-P-E-G-T-P-N-G-G-S-T-T-L-P-S-A-P-P-P-A-S-A-G-L-K-S-H-P-P-P-P-E-K |
### FUNCTION Both kawaguchipeptin A and B, which only differ by post-translational modifications, have antibacterial activities, since they inhibit the growth of the Gram-positive bacterium Saureus at a concentration of 1 ug/mL ### SEQUENCE -M-K-N-P-T-L-L-P-K-L-T-A-P-V-E-R-P-A-V-T-S-S-D-L-K-Q-A-S-S-V-D-A-A-W-L-N-G-D-N-N-W-S-T-P-F-A-G-V-N-A-A-W-L-N-G-D-N-N-W-S-T-P-F-A-G-V-N-A-A-W-L-N-G-D-N-N-W-S-T-P-F-A-A-D-G-A-E |
### FUNCTION Catalyzes the hydrolysis of 3-deoxy-D-manno-octulosonate 8-phosphate and inorganic phosphate ### SEQUENCE -M-S-K-A-G-A-S-L-A-T-C-Y-G-P-V-S-A-D-V-M-A-K-A-E-N-I-R-L-L-I-L-D-V-D-G-V-L-S-D-G-L-I-Y-M-G-N-N-G-E-E-L-K-A-F-N-V-R-D-G-Y-G-I-R-C-A-L-T-S-D-I-E-V-A-I-I-T-G-R-K-A-K-L-V-E-D-R-C-A-T-L-G-I-T-H-L-Y-Q-G-Q-S-N-K-L-I-A-F-S-D-L-L-E-K-L-A-I-A-P-E-N-V-A-Y-V-G-D-D-L-I-D-W-P-V-M-E-K-V-G-L-S-V-A-V-A-D-A-H-P-L-L-I-P-R-A-D-Y-V-T-R-I-A-G-G-R-G-A-V-R-E-V-C-D-L-L-L-L-A-Q-G-K-L-D-E-A-K-G-Q-S-I |
### FUNCTION Has antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and against fungi with minimum inhibitory concentration between 078 uM and 50 uM Shows little hemolytic activity even at a concentration of 100 uM ### SEQUENCE -M-M-I-K-I-A-V-V-L-C-A-V-M-A-T-T-M-V-R-A-K-Y-V-E-E-Q-E-L-A-D-L-L-D-L-L-I-S-E-E-V-S-S-P-D-D-A-V-A-L-Q-G-W-W-R-R-T-V-D-K-V-R-N-A-G-R-K-V-A-G-F-A-S-K-A-C-G-A-L-G-H-S-P-Q-E-A-R-A-K-V-L-E-A-F-P-E-M-K-E-A-D-L-D-E-E-D-I-G-K-Y-C-G-Y-A-H-A-L-N-G-R |
### FUNCTION Has antimicrobial activity against Gram-negative bacteria, Gram-positive bacteria and against fungi with minimum inhibitory concentration between 078 uM and 50 uM Shows little hemolytic activity at concentrations up to 125 uM but >50% lysis at 100 uM ### SEQUENCE -M-M-I-K-I-A-V-V-L-C-A-V-M-A-T-S-M-V-F-A-N-D-V-K-E-Q-E-L-A-D-L-L-D-L-L-I-S-E-E-V-S-S-P-D-D-A-V-A-E-S-W-G-H-K-L-R-S-S-W-N-K-V-K-H-A-V-K-K-G-A-G-Y-A-S-G-A-C-R-V-L-G-H-S-P-Q-E-A-R-A-K-V-L-E-A-F-P-E-M-K-E-S-D-L-D-E-E-Q-V-G-K-Y-C-A-V-A-H-A-I-H-G-R |
### FUNCTION Regulates negatively salt stress responses and Na ### SEQUENCE -M-A-Q-Y-H-Q-Q-H-E-M-K-Q-T-M-A-E-T-Q-Y-V-T-A-P-P-P-M-G-Y-P-V-M-M-K-D-S-P-Q-T-V-Q-P-P-H-E-G-Q-S-K-G-S-G-G-F-L-R-G-C-L-A-A-M-C-C-C-C-V-L-D-C-V-F |
### FUNCTION Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism ### SEQUENCE -M-S-P-K-R-I-I-S-T-P-L-A-P-Q-P-I-G-P-Y-S-Q-A-V-Q-V-G-N-T-V-Y-L-S-G-Q-I-G-M-N-V-R-T-N-E-M-V-T-G-P-I-R-D-E-A-Q-Q-A-F-T-N-M-K-A-V-V-E-A-S-G-A-K-M-S-D-V-V-K-V-N-I-F-I-R-N-F-N-D-F-P-A-I-N-D-V-M-K-E-F-F-Q-S-P-F-P-A-R-S-T-V-G-V-A-E-L-P-K-N-A-R-V-E-I-E-S-I-V-V-I-E |
### FUNCTION Brassicaceae-specific phytocytokine ### SEQUENCE -M-T-K-N-M-T-K-K-K-M-G-L-M-S-P-N-I-A-A-F-V-L-P-M-L-L-V-L-F-T-I-S-S-Q-V-E-V-V-E-S-T-G-R-K-L-S-W-A-F-N-G-A-P-I-V-F-T-P-P-S-S-S-C-G-G-S-P-A-A-V-M-A-S-E-W-M-P-R-R-P-C-R-R-T-R-P-P-G-T-N-I-P-V-S-Q-S-P |
### FUNCTION Selectively interacts with vasopressin V2 receptor Fluorescent MQ1 probes could also be used for imaging V2R-overexpressing cancer cells ### SEQUENCE -R-P-S-F-C-N-L-P-V-K-P-G-P-C-N-G-F-F-S-A-F-Y-Y-S-Q-K-T-N-K-C-H-S-F-T-Y-G-G-C-K-G-N-A-N-R-F-S-T-I-E-K-C-R-R-T-C-V-G |
### FUNCTION Has antimicrobial activity against Gram-negative bacterium Ecoli Has moderate hemolytic activity towards human erythrocytes at a concentration of 522 uM ### SEQUENCE -M-N-F-K-Y-I-I-A-V-S-F-L-I-A-S-A-Y-A-R-S-E-E-Y-D-I-Q-S-L-S-Q-R-D-V-L-E-E-E-S-L-R-K-I-R-G-I-G-S-A-I-L-S-A-G-K-S-I-I-K-G-L-A-K-G-L-A-E-H-F-G-K-R-T-A-E-D-H-E-V-M-K-R-L-E-A-A-M-R-D-L-D-S-L-D-Y-P-E-E-A-S-E-R-E-T-R-G-F-N-Q-E-E-K-E-K-R-I-I-G-P-V-L-G-L-V-G-K-A-L-G-G-L-L-G |
### FUNCTION Chloroplast chaperone required for RuBisCo biogenesis and translational regulation of the RuBisCo large subunit ### SEQUENCE -M-N-S-A-A-L-N-A-R-T-A-S-V-A-P-Q-P-Q-A-C-H-A-C-K-C-R-Q-L-L-S-R-R-V-P-P-A-Q-R-Q-V-E-C-S-A-I-A-P-E-T-L-Q-D-I-I-V-G-G-A-V-V-G-A-V-S-V-A-L-Y-A-G-L-K-K-D-P-V-P-C-S-L-C-Q-G-T-G-G-I-R-C-F-A-C-G-G-D-G-R-N-A-T-V-S-R-D-D-L-Y-D-S-K-A-L-G-G-G-V-A-P-P-K-R-D-P-L-G-R-T-I-N-P-R-D-C-K-V-C-R-G-A-G-L-V-L-C-S-Q-C-K-G-T-G-F-Q-S-A-F |
### FUNCTION Blocks voltage-gated potassium channels Kv74/KCNQ4 Targets the pore domain, in particular negatively charged residues 'Asp-266' and 'Asp-288', of KCNQ4 and probably other KCNQ channel family members where these residues are conserved In vivo, shows vasoconstrictive activity resulting in acute hypertension when injected intravenously in mice Also induces coronary vasospasms ultimately leading to heart failure Induces seizures when injected into the hippocampus of mice Decreases respiratory rate while increasing respiratory amplitude, probably by triggering a contraction of the bronchial ring ### SEQUENCE -M-E-K-K-I-I-F-L-V-F-L-V-A-L-L-A-L-P-G-F-I-S-T-E-V-I-K-K-D-T-P-Y-K-K-R-K-F-P-Y-K-S-E-C-L-K-A-C-A-T-S-F-T-G-G-D-E-S-R-I-Q-E-G-K-P-G-F-F-K-C-T-C-Y-F-T-T-G |
### FUNCTION Antimicrobial peptide that displays antibacterial, antiprotozoal, and antiviral activity ### SEQUENCE -M-A-F-L-K-K-S-L-F-L-V-L-F-L-G-I-V-S-L-S-V-C-E-E-E-K-R-E-G-E-E-K-E-E-K-R-E-E-E-E-G-K-E-E-N-E-D-G-N-E-E-H-K-E-K-R-F-L-G-A-I-L-K-I-G-H-A-L-A-K-T-V-L-P-M-V-T-N-A-F-K-P-K-Q |
### FUNCTION Antimicrobial peptide that displays antibacterial and antiprotozoal activity ### SEQUENCE -M-A-F-L-K-K-S-L-F-L-V-L-F-L-G-L-V-S-L-S-I-G-E-E-E-K-R-E-E-E-E-K-N-E-E-G-A-N-Q-E-E-N-A-E-N-K-E-K-R-F-I-G-T-L-I-P-L-A-L-G-A-L-T-K-L-F-K-G |
### FUNCTION Product of the upstream open reading frame of DDIT3/CHOP that is specifically produced in absence of stress, thereby preventing translation of downstream stress effector DDIT3/CHOP ### SEQUENCE -M-L-K-M-S-G-W-Q-R-Q-S-Q-N-N-S-R-N-L-R-R-E-C-S-R-R-K-C-I-F-I-H-H-H-T |
### FUNCTION Catalyzes the formation of thebaine from ### SEQUENCE -M-A-P-L-G-V-S-G-L-V-G-K-L-S-T-E-L-E-V-D-C-D-A-E-K-Y-Y-N-M-Y-K-H-G-E-D-V-K-K-A-V-P-H-L-C-V-D-V-K-I-I-S-G-D-P-T-S-S-G-C-I-K-E-W-N-V-N-I-D-G-K-T-I-R-S-V-E-E-T-T-H-D-D-E-T-K-T-L-R-H-R-V-F-E-G-D-V-M-K-D-F-K-K-F-D-T-I-M-V-V-N-P-K-P-D-G-N-G-C-V-V-T-R-S-I-E-Y-E-K-T-N-E-N-S-P-T-P-F-D-Y-L-Q-F-G-H-Q-A-I-E-D-M-N-K-Y-L-R-D-S-E-S-N |
### FUNCTION Omega-conotoxins act at presynaptic membranes, they bind and block voltage-gated calcium channels It is 9-fold more potent in displacing radiolabeled omega-conotoxin GVIA from fish brain membranes than from human SH-SY5Y cells ### SEQUENCE -M-K-L-T-C-V-V-I-V-A-V-L-F-L-T-A-C-Q-L-I-T-A-D-D-S-R-S-T-Q-R-H-R-A-L-R-S-T-T-K-L-S-M-S-T-R-C-K-P-P-G-S-K-C-S-P-S-M-R-D-C-C-T-T-C-I-S-Y-T-K-R-C-R-K-Y-Y-N |
### FUNCTION Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome ### SEQUENCE -M-A-T-E-A-P-V-E-A-T-E-I-P-S-V-A-A-A-E-T-V-E-K-Q-P-H-K-L-E-R-K-W-T-F-W-F-D-N-Q-S-K-P-K-Q-G-V-A-W-G-S-S-L-R-K-A-Y-T-F-E-T-V-E-E-F-W-S-L-Y-D-Q-I-F-K-P-S-K-V-T-V-N-A-D-F-H-L-F-K-A-G-I-E-P-K-W-E-D-P-E-C-A-N-G-G-K-W-T-A-T-S-S-R-K-A-N-L-E-T-M-W-L-E-T-L-M-A-L-V-G-E-Q-F-D-E-S-E-D-I-C-G-V-V-A-S-V-R-R-S-Q-D-K-L-S-L-W-T-K-T-A-T-N-E-A-A-Q-M-G-I-G-R-K-W-K-E-I-I-D-A-E-K-I-S-Y-S-F-H-D-D-S-K-R-E-R-S-A-K-S-R-Y-T-V |
### FUNCTION Snake venom phospholipase A2 ### SEQUENCE -M-R-T-L-W-I-M-A-V-L-L-L-G-V-E-G-D-L-M-Q-F-E-T-L-I-M-K-I-A-K-R-S-G-M-F-W-Y-S-A-Y-G-C-Y-C-G-W-G-G-Q-G-R-P-Q-D-A-T-D-R-C-C-F-V-H-D-C-C-Y-G-K-V-T-G-C-D-P-K-L-D-S-Y-T-Y-S-V-E-N-G-D-V-V-C-G-G-N-D-P-C-K-K-E-I-C-E-C-D-R-A-A-A-I-C-F-R-D-N-K-V-T-Y-D-N-K-Y-W-R-F-P-P-Q-N-C-K-E-E-S-E-P-C |
### FUNCTION Potently and reversibly inhibits some human voltage-gated sodium channels ### SEQUENCE -E-C-K-G-F-G-K-S-C-V-P-G-K-N-E-C-C-S-G-L-T-C-S-N-K-H-K-W-C-K-V-L-L |
### FUNCTION Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides ### SEQUENCE -M-K-L-L-A-P-V-L-W-A-M-A-A-L-G-V-T-W-L-V-A-V-D-S-K-E-S-C-T-K-H-S-N-G-C-S-T-P-L-R-L-P-C-Q-E-Y-F-R-P-A-C-D-I-H-D-N-C-Y-H-C-G-T-I-F-G-I-S-R-K-E-C-D-D-A-F-L-K-D-M-N-T-L-C-K-K-L-G-S-N-S-A-T-C-P-A-R-G-K-R-E-V-T-S-H-R-A-T-S-I-A-H-S-R-L-W-K-T-A-L-D-Q-K-S-F-L-N-R-K-A-R-Q-A-I-L-L-T-P-N-S-C-L-Y-W-A-N-N-F-Y-M-A-V-H-V-F-G-A-R-S-Y-S-R-T-T-D-P-K-D-C-Q-G-L-K-H-C-L-P-N-H |
### FUNCTION First cyclic scorpion trypsin inhibitor Does not inhibit chymotrypsin ### SEQUENCE -M-K-F-I-I-V-L-L-L-L-T-A-L-T-L-T-S-I-P-V-I-E-G-I-L-K-R-C-K-T-Y-D-D-C-K-D-V-C-K-A-R-K-G-K-C-E-F-G-I-C-K-C-M-I-K-S-G-K |
### FUNCTION Pore-forming protein that forms hydrophilic pores and causes cytolysis ### SEQUENCE -M-L-L-Y-I-C-L-V-N-L-L-L-P-L-S-V-G-A-A-S-G-A-A-L-G-V-I-A-K-V-G-V-D-A-A-L-Q-Q-I-D-D-V-W-K-G-K-T-V-R-Y-W-K-C-A-V-E-N-R-S-S-K-T-L-Y-A-L-G-T-T-Q-E-S-G-S-M-T-T-V-F-A-D-I-P-P-K-S-T-G-V-F-V-W-E-K-S-R-G-A-A-K-G-A-V-G-V-V-H-Y-K-Y-G-N-K-V-L-N-I-M-A-S-I-P-Y-D-W-N-L-Y-K-A-W-A-N-V-H-L-S-D-H-K-E-S-F-S-D-L-Y-K-G-K-N-G-A-K-Y-P-T-R-A-G-N-W-G-E-V-D-G-T-K-F-F-L-T-E-K-S-H-A-E-F-K-V-I-F-S-G |
### FUNCTION Component of the multi-pass translocon ### SEQUENCE -M-S-T-N-N-M-S-D-P-R-R-P-N-K-V-L-R-Y-K-P-P-P-S-E-C-N-P-A-L-D-D-P-T-P-D-Y-M-N-L-L-G-M-I-F-S-M-C-G-L-M-L-K-L-K-W-C-A-W-V-A-V-Y-C-S-F-I-S-F-A-N-S-R-S-S-E-D-T-K-Q-M-M-S-S-F-M-L-S-I-S-A-V-V-M-S-Y-L-Q-N-P-Q-P-M-T-P-P-W |
### FUNCTION Calcium-selective channel required to prevent calcium stores from overfilling, thereby playing a key role in calcium homeostasis ### SEQUENCE -M-S-T-M-F-A-D-T-L-L-I-V-F-I-S-V-C-T-A-L-L-A-E-G-I-T-W-V-L-V-Y-R-T-D-K-Y-K-R-L-K-A-E-V-E-K-Q-S-K-K-L-E-K-K-K-E-T-I-T-E-S-A-G-R-Q-Q-K-K-K-I-E-R-Q-E-E-K-L-K-N-N-N-R-D-L-S-M-V-R-M-K-S-M-F-A-I-G-F-C-F-T-A-L-M-G-M-F-N-S-I-F-D-G-R-V-V-A-K-L-P-F-T-P-L-S-Y-I-Q-G-L-S-H-R-N-L-L-G-D-D-T-T-D-C-S-F-I-F-L-Y-I-L-C-T-M-S-I-R-Q-N-I-Q-K-I-L-G-L-A-P-S-R-A-A-T-K-Q-A-G-G-F-L-G-P-P-P-P-S-G-K-F-S |
### FUNCTION Component of the multi-pass translocon ### SEQUENCE -M-S-G-G-R-R-K-E-E-P-P-Q-P-Q-L-A-N-G-A-L-K-V-S-V-W-S-K-V-L-R-S-D-A-A-W-E-D-K-D-E-F-L-D-V-I-Y-W-F-R-Q-I-I-A-V-V-L-G-V-I-W-G-V-L-P-L-R-G-F-L-G-I-A-G-F-C-V-I-N-A-G-V-L-Y-L-Y-F-S-N-Y-L-Q-I-D-E-E-E-Y-G-G-T-W-E-L-T-K-E-G-F-M-T-S-F-A-L-F-M-V-I-W-I-I-F-Y-T-A-I-H-Y-D |
### FUNCTION Essential component of the Ost-alpha/Ost-beta complex, a heterodimer that acts as the intestinal basolateral transporter responsible for bile acid export from enterocytes into portal blood The Ost-alpha/Ost-beta complex efficiently transports the major species of bile acids ### SEQUENCE -M-N-Y-S-E-K-L-T-G-A-P-P-M-T-E-V-P-L-E-L-L-E-E-M-L-W-F-F-R-V-E-D-A-T-P-W-N-C-S-M-F-V-L-A-A-L-V-A-I-I-S-F-I-L-L-G-R-N-I-Q-A-N-R-N-Q-K-K-L-P-P-E-K-Q-T-P-E-V-L-Y-L-A-E-G-G-N-K-D-D-K-N-L-T-S-L-T-E-T-L-L-S-E-K-P-T-L-A-Q-G-E-M-E-A-K-C-S-D-V-P-R-V-H-L-P-D-P-Q-E-P-E-S |
### FUNCTION Brassicaceae-specific phytocytokine ### SEQUENCE -M-A-A-K-T-S-N-L-V-A-L-L-L-S-L-F-L-L-L-L-S-I-S-S-Q-V-G-L-G-E-A-K-R-N-L-R-N-N-L-R-L-D-C-V-S-H-P-S-P-P-P-P-H-R-S-M-A-P-P-I-F-V-P-P-S-T-S-H-K-G-Q-G-P |
### FUNCTION May act as a scaffolding protein within caveolar membranes Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation Mediates the recruitment of CAVIN proteins ### SEQUENCE -M-S-G-G-K-Y-V-D-S-E-G-H-L-Y-T-V-P-I-R-E-Q-G-N-I-Y-K-P-N-N-K-A-M-A-D-E-L-S-E-K-Q-V-Y-D-A-H-T-K-E-I-D-L-V-N-R-D-P-K-H-L-N-D-D-V-V-K-I-D-F-E-D-V-I-A-E-P-E-G-T-H-S-F-D-G-I-W-K-A-S-F-T-T-F-T-V-T-K-Y-W-F-Y-R-L-L-S-A-L-F-G-I-P-M-A-L-V-W-G-I-Y-F-A-I-L-S-F-L-H-I-W-A-V-V-P-C-I-K-S-F-L-I-E-I-Q-C-I-S-R-V-Y-S-I-Y-V-H-T-V-C-D-P-L-F-E-A-V-G-K-I-F-S-N-V-R-I-N-L-Q-K-E-I |
### FUNCTION May act as a scaffolding protein within caveolar membranes Interacts directly with G-protein alpha subunits and can functionally regulate their activity Acts as an accessory protein in conjunction with CAV1 in targeting to lipid rafts and driving caveolae formation The Ser-36 phosphorylated form has a role in modulating mitosis in endothelial cells Positive regulator of cellular mitogenesis of the MAPK signaling pathway Required for the insulin-stimulated nuclear translocation and activation of MAPK1 and STAT3, and the subsequent regulation of cell cycle progression ### SEQUENCE -M-G-L-E-T-E-K-A-D-V-Q-L-F-M-D-D-D-S-Y-S-R-H-S-G-V-D-Y-A-D-P-D-K-F-A-D-S-G-S-D-R-D-P-H-R-L-N-S-N-L-K-V-G-F-E-D-V-I-A-E-P-V-S-T-H-S-F-D-K-V-W-I-C-S-H-A-L-F-E-I-S-K-Y-V-I-Y-K-F-L-T-L-F-L-A-I-P-L-A-F-A-A-G-I-L-F-A-T-L-S-C-L-H-I-W-I-I-M-P-F-V-K-T-C-L-M-V-L-P-S-V-Q-T-I-W-K-S-I-T-D-V-V-I-A-P-L-C-T-S-V-G-R-S-F-S-S-V-S-L-Q-L-S-H-D |
### FUNCTION May act as a scaffolding protein within caveolar membranes Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation Mediates the recruitment of CAVIN proteins ### SEQUENCE -M-S-G-G-K-Y-V-D-S-E-G-H-L-Y-T-V-P-I-R-E-Q-G-N-I-Y-K-P-N-N-K-A-M-A-E-E-I-N-E-K-Q-V-Y-D-A-H-T-K-E-I-D-L-V-N-R-D-P-K-H-L-N-D-D-V-V-K-I-D-F-E-D-V-I-A-E-P-E-G-T-H-S-F-D-G-I-W-K-A-S-F-T-T-F-T-V-T-K-Y-W-F-Y-R-L-L-S-A-L-F-G-I-P-M-A-L-I-W-G-I-Y-F-A-I-L-S-F-L-H-I-W-A-V-V-P-C-I-K-S-F-L-I-E-I-Q-C-I-S-R-V-Y-S-I-Y-V-H-T-F-C-D-P-F-F-E-A-V-G-K-I-F-S-N-I-R-I-N-M-Q-K-E-I |
### FUNCTION Ghrelin is the ligand for growth hormone secretagogue receptor type 1 ### SEQUENCE -M-P-S-P-G-T-V-C-S-L-L-L-L-G-M-L-W-L-D-L-A-M-A-G-S-S-F-L-S-P-E-H-Q-R-A-Q-Q-R-K-E-S-K-K-P-P-A-K-L-Q-P-R-A-L-G-G-W-L-R-P-E-D-G-D-Q-A-E-G-A-E-D-E-L-E-I-Q-F-N-A-P-F-D-V-G-I-K-L-S-G-V-Q-Y-Q-Q-H-S-Q-A-L-G-K-F-L-Q-D-I-L-W-E-E-A-K-E-A-P-A-D-K |
### FUNCTION Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation The tagging system is termed pupylation Among the identified substrates are the SodA and Ino1 proteins ### SEQUENCE -M-A-Q-E-Q-T-K-R-G-G-G-G-G-E-D-D-D-L-P-G-A-S-A-A-G-Q-E-R-R-E-K-L-T-E-E-T-D-D-L-L-D-E-I-D-D-V-L-E-E-N-A-E-D-F-V-R-A-Y-V-Q-K-G-G-Q |
### FUNCTION This bird and reptile-specific postsynaptic neurotoxin inhibits the chick muscle alpha-1-beta-1-gamma-delta 100-fold more compared with the mouse receptor In vivo, produces rapid flaccid paralysis, dyspnea and increased respiratory rate in geckos At sublethal doses geckos were immobilized for up to three days and then recovered Chicks injected with lethal doses showed rapid onset of inactivity, dyspnea and neck droop, and no extended paralysis with survival was seen ### SEQUENCE -M-K-T-L-L-L-A-V-A-V-V-A-F-V-C-L-G-S-A-D-Q-L-G-L-G-R-Q-Q-I-D-W-G-Q-G-Q-A-V-G-P-P-Y-T-L-C-F-E-C-N-R-M-T-S-S-D-C-S-T-A-L-R-C-Y-R-G-S-C-Y-T-L-Y-R-P-D-E-N-C-E-L-K-W-A-V-K-G-C-A-E-T-C-P-T-A-G-P-N-E-R-V-K-C-C-R-S-P-R-C-N-D-D |
### FUNCTION This bird and reptile-specific postsynaptic neurotoxin inhibits the chick muscle alpha-1-beta-1-gamma-delta 100-fold more compared with the mouse receptor In vivo, produces rapid flaccid paralysis, dyspnea and increased respiratory rate in geckos At sublethal doses geckos were immobilized for up to three days and then recovered Chicks injected with lethal doses showed rapid onset of inactivity, dyspnea and neck droop, and no extended paralysis with survival was seen ### SEQUENCE -M-K-T-L-L-L-A-V-A-V-V-A-F-V-C-L-G-S-A-D-Q-L-G-L-G-R-Q-Q-I-D-W-G-K-G-Q-A-K-G-P-P-Y-T-L-C-F-E-C-N-R-E-T-C-S-N-C-F-K-D-N-R-C-P-P-Y-H-R-T-C-Y-T-L-Y-R-P-D-G-N-G-E-M-K-W-A-V-K-G-C-A-K-T-C-P-T-A-Q-P-G-E-S-V-Q-C-C-N-T-P-K-C-N-D-Y |
### FUNCTION Terminal enzyme of the cyclooxygenase ### SEQUENCE -M-P-P-P-V-L-A-L-V-S-G-Q-A-L-P-A-F-L-L-C-S-T-L-L-V-I-K-M-Y-V-V-A-V-I-T-G-Q-V-R-L-R-K-K-A-F-A-N-P-E-D-A-L-R-H-G-G-L-Q-Y-C-R-S-D-Q-D-V-D-R-C-L-R-A-H-R-N-D-M-E-T-I-Y-P-F-L-F-L-G-F-V-Y-S-F-L-G-P-D-P-F-I-A-Q-M-H-F-L-V-F-F-L-G-R-M-V-H-T-V-A-Y-L-G-K-L-R-A-P-T-R-S-L-A-Y-T-V-A-Q-L-P-C-A-S-M-A-L-Q-I-V-W-E-A-A-C-H-L |
### FUNCTION RNA-binding and decapping enzyme that catalyzes the cleavage of the cap structure of snoRNAs and mRNAs in a metal-dependent manner Part of the U8 snoRNP complex that is required for the accumulation of mature 58S and 28S rRNA Has diphosphatase activity and removes m7G and/or m227G caps from U8 snoRNA and leaves a 5'monophosphate on the RNA Catalyzes also the cleavage of the cap structure on mRNAs Does not hydrolyze cap analog structures like 7-methylguanosine nucleoside triphosphate Also hydrolysis m7G- and m227G U3-capped RNAs but with less efficiencies Has broad substrate specificity with manganese or cobalt as cofactor and can act on various RNA species Binds to the U8 snoRNA ### SEQUENCE -M-A-G-M-R-R-L-E-L-S-E-A-L-H-L-G-P-G-W-R-H-A-C-H-A-L-L-Y-A-P-D-P-G-L-L-F-G-R-I-P-L-R-Y-A-V-L-M-Q-M-R-F-D-G-R-L-G-F-P-G-G-F-V-D-L-R-D-G-S-L-E-D-G-L-N-R-E-L-G-E-E-L-G-E-A-A-G-A-F-R-V-E-R-A-D-Y-R-S-S-H-A-G-S-R-P-R-V-V-A-H-F-Y-T-K-L-L-T-L-E-Q-L-T-A-V-E-M-G-A-P-R-A-R-D-H-G-L-E-V-L-G-L-V-R-V-P-L-Y-T-L-R-D-G-V-G-G-L-P-A-F-L-E-N-T-F-I-G-N-A-R-E-Q-L-L-E-A-V-Q-N-L-G-L-L-E-P-G-S-F-A-R-L-K-I-S-T-P-P |
### FUNCTION Immunity-related GTPase that plays important roles in innate immunity and inflammatory response ### SEQUENCE -M-E-A-M-N-V-E-K-A-S-A-D-G-N-L-P-E-V-I-S-N-I-K-E-T-L-K-I-V-S-R-T-P-V-N-I-T-M-A-G-D-S-G-N-G-M-S-T-F-I-S-A-L-R-N-T-G-H-E-G-K-A-S-P-P-T-E-L-V-K-A-T-Q-R-C-A-S-Y-F-S-S-H-F-S-N-V-V-L-W-D-L-P-G-T-G-S-A-T-T-T-L-E-N-Y-L-M-E-M-Q-F-N-R-Y-D-F-I-M-V-A-S-A-Q-F-S-M-N-H-V-M-L-A-K-T-A-E-D-M-G-K-K-F-Y-I-V-W-T-K-L-D-M-D-L-S-T-G-A-L-P-E-V-Q-L-L-Q-I-R-E-N-V-L-E-N-L-Q-K-E-R-V-C-E-Y |
### FUNCTION Essential component of the SCF ### SEQUENCE -M-S-T-T-V-T-L-T-S-S-D-G-V-D-L-T-V-D-R-D-V-A-E-R-S-V-L-I-K-N-M-L-E-D-L-G-E-S-G-E-A-I-P-I-P-N-V-N-E-V-V-L-K-K-V-I-E-W-C-T-H-H-K-N-D-P-P-S-T-G-D-D-D-D-S-R-R-K-T-T-D-I-D-E-W-D-Q-K-F-M-Q-V-D-Q-E-M-L-F-E-I-I-L-A-A-N-Y-L-D-I-K-A-L-L-D-V-G-C-K-T-V-A-N-M-I-K-G-K-S-P-E-E-I-R-K-T-F-N-I-Q-N-D-F-T-P-E-E-E-D-Q-I-R-R-E-N-E-W-A-E-E |
### FUNCTION Essential component of the SCF ### SEQUENCE -M-T-T-V-T-L-T-S-S-D-G-V-D-I-T-V-D-R-D-V-A-E-R-S-I-L-I-K-N-M-L-E-D-L-G-E-S-D-E-A-I-P-I-P-N-V-N-E-V-V-L-K-K-V-I-E-W-C-T-H-H-K-N-D-P-P-S-T-G-D-D-D-D-S-R-R-K-T-T-D-I-D-E-W-D-Q-K-F-M-Q-V-D-Q-E-M-L-F-E-I-I-L-A-A-N-Y-L-D-I-K-A-L-L-D-V-G-C-K-T-V-A-N-M-I-K-G-K-S-P-E-E-I-R-K-T-F-N-I-Q-N-D-F-T-P-E-E-E-D-Q-I-R-R-E-N-E-W-A-E-E |
### FUNCTION Extracellular signal peptide that regulates cell fate Represses tracheary element differentiation but promotes the formation of procambial cells adjacent to phloem cells in the veins ### SEQUENCE -M-D-I-D-L-L-W-S-F-G-G-W-F-F-I-L-F-P-E-T-I-N-Y-C-M-A-K-L-R-S-T-S-Q-I-S-H-F-T-N-P-R-S-C-S-S-L-F-F-V-A-L-L-I-I-T-I-L-I-T-M-L-Q-S-S-T-S-M-E-V-T-S-L-P-T-H-Q-P-T-S-S-N-S-H-D-E-S-S-T-S-S-T-A-T-T-T-T-D-L-H-P-K-R-T-H-H-Q-S-H-P-K-P-T-R-S-F-E-A-G-A-H-E-V-P-S-G-P-N-P-I-S-N-R |
### FUNCTION Inhibitor of neuronal axonal outgrowth Acts as a negative regulator of CDC42 and STAT3 and a positive regulator of STMN2 Positive regulator of CDC27 ### SEQUENCE -M-N-P-V-Y-S-P-G-S-S-G-V-P-Y-A-N-A-K-G-I-G-Y-P-A-G-F-P-M-G-Y-A-A-A-A-P-A-Y-S-P-N-M-Y-P-G-A-N-P-T-F-Q-T-G-Y-T-P-G-T-P-Y-K-V-S-C-S-P-T-S-G-A-V-P-P-Y-S-S-S-P-N-P-Y-Q-T-A-V-Y-P-V-R-S-A-Y-P-Q-Q-S-P-Y-A-Q-Q-G-T-Y-Y-T-Q-P-L-Y-A-A-P-P-H-V-I-H-H-T-T-V-V-Q-P-N-G-M-P-A-T-V-Y-P-A-P-I-P-P-P-R-G-N-G-V-T-M-G-M-V-A-G-T-T-M-A-M-S-A-G-T-L-L-T-A-H-S-P-T-P-V-A-P-H-P-V-T-V-P-T-Y-R-A-P-G-T-P-T-Y-S-Y-V-P-P-Q-W |
### FUNCTION Probable E2 ubiquitin-protein ligase that catalyzes the covalent attachment of ubiquitin to target proteins May facilitate the monoubiquitination and degradation of MTOR and CCNE1 through interaction with FBXW7 ### SEQUENCE -M-K-E-L-Q-D-I-A-R-L-S-D-R-F-I-S-V-E-L-V-D-E-S-L-F-D-W-N-V-K-L-H-Q-V-D-K-D-S-V-L-W-Q-D-M-K-E-T-N-T-E-F-I-L-L-N-L-T-F-P-D-N-F-P-F-S-P-P-F-M-R-V-L-S-P-R-L-E-N-G-Y-V-L-D-G-G-A-I-C-M-E-L-L-T-P-R-G-W-S-S-A-Y-T-V-E-A-V-M-R-Q-F-A-A-S-L-V-K-G-Q-G-R-I-C-R-K-A-G-K-S-K-K-S-F-S-R-K-E-A-E-A-T-F-K-S-L-V-K-T-H-E-K-Y-G-W-V-T-P-P-V-S-D-G |
### FUNCTION Major component of the transverse central element of synaptonemal complexes , formed between homologous chromosomes during meiotic prophase Required for chromosome loading of the central element-specific SCS proteins, and for initiating synapsis between homologous chromosomes Chromosome loading appears to require SYCP1 Required for fertility ### SEQUENCE -M-D-D-A-D-P-E-E-R-N-Y-D-N-M-L-K-M-L-S-D-L-N-K-D-L-E-K-L-L-E-E-M-E-K-I-S-V-Q-A-T-W-M-A-Y-D-M-V-V-M-R-T-N-P-T-L-A-E-S-M-R-R-L-E-D-A-F-V-N-C-K-E-E-M-E-K-N-W-Q-E-L-L-H-E-T-K-Q-R-L |
### FUNCTION Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline -allantoin ### SEQUENCE -M-D-I-N-V-V-N-A-L-A-Y-E-D-F-V-K-L-F-G-N-V-V-E-K-C-P-L-I-S-A-A-I-W-S-Y-R-P-F-K-D-L-A-D-I-E-A-R-I-S-E-F-I-H-S-L-P-D-S-G-K-E-G-I-L-R-C-H-P-D-L-A-G-R-D-L-Q-S-G-T-L-T-P-E-S-Q-E-E-Q-S-Q-A-G-M-T-T-L-D-S-A-E-I-V-H-M-Y-R-L-N-S-E-Y-K-E-R-F-G-F-P-F-V-I-C-A-R-L-N-N-K-A-D-I-V-R-Q-L-S-E-R-L-K-N-R-R-T-A-E-L-E-C-A-I-E-E-V-K-K-I-C-S-L-R-L-H-S-I-V-L-S-D-I-Q-T-K-L |
### FUNCTION May act as a scaffolding protein within caveolar membranes Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation Mediates the recruitment of CAVIN proteins ### SEQUENCE -M-S-G-G-K-Y-V-D-S-E-G-H-L-Y-T-L-P-I-R-E-Q-G-N-I-Y-K-P-N-N-K-A-M-A-E-D-M-N-E-K-Q-V-Y-D-A-H-T-K-E-I-D-L-V-N-R-D-P-K-H-L-N-D-D-V-V-K-I-D-F-E-D-V-I-A-E-P-E-G-T-H-S-F-D-G-I-W-K-A-S-F-T-T-F-T-V-T-K-Y-W-F-Y-R-L-L-S-G-I-F-G-I-P-M-A-L-I-W-G-V-Y-F-A-I-L-S-F-L-H-I-W-A-V-V-P-C-I-K-S-F-L-I-E-I-Q-C-I-S-R-V-Y-S-I-Y-V-H-T-F-C-D-P-L-F-E-A-I-G-K-I-F-S-N-I-R-I-S-T-Q-K-E-I |
### FUNCTION Required for defense response to Xanthomonas campestris pv vesicatoria In heterologous systems, confers resistance to bacterial pathogens such as Pseudomonas syringae pv tomato but susceptibility to pathogenic oomycetes such as Hylaloperonospora parasitica when expressed in Arabidopsis thaliana May be involved in the regulation of responses to bitoic and abiotic stresses ### SEQUENCE -M-T-P-P-P-T-S-T-V-P-P-Y-V-S-L-I-V-R-I-L-T-L-I-C-L-L-I-S-F-I-V-I-A-T-N-N-Q-T-V-S-T-V-A-G-D-V-K-I-K-F-K-D-F-Y-A-Y-R-Y-L-I-A-T-V-I-I-G-M-A-Y-T-L-L-Q-I-A-F-S-I-S-L-L-T-T-G-N-R-I-G-G-E-G-F-L-L-F-D-F-Y-G-D-K-F-I-S-Y-F-L-V-T-G-A-A-A-S-F-G-M-T-Q-D-L-K-Q-L-E-G-S-D-N-Y-S-K-F-L-N-T-S-N-A-A-A-S-L-C-L-I-G-F-F-F-A-V-A-S-S-I-F-S-S-Y-N-L-P-K-R-I |
### FUNCTION This phospholipase A2 inhibitor neutralizes the activity of basic PLA2 myotoxins of its own and related venoms The inhibitory profile shows specificity towards group II PLA2, either belonging to the catalytically-active subtypes ### SEQUENCE -M-R-L-I-L-L-S-G-L-L-L-L-G-T-F-L-A-N-G-D-E-K-D-S-D-V-Q-M-L-N-S-M-I-E-A-V-M-I-L-Q-R-D-F-A-N-L-R-H-A-L-M-T-V-H-N-A-R-S-F-G-R-G-S-E-R-L-Y-V-T-N-K-E-V-S-K-F-E-G-L-E-E-I-C-S-Q-A-G-G-H-I-P-S-P-Q-L-E-N-Q-N-K-A-F-E-D-V-L-E-R-H-N-K-A-A-Y-L-V-V-G-D-S-A-N-F-T-N-W-A-A-G-Q-P-N-E-A-D-G-T-C-V-K-A-D-T-H-G-S-W-H-S-A-S-C-D-D-N-L-L-V-V-C-E-F-Y-F-I-L |
### FUNCTION Seems to act as a signaling molecule involved in the maintenance of iron homeostasis Seems to be required in conjunction with HFE to regulate both intestinal iron absorption and iron storage in macrophages ### SEQUENCE -M-K-T-F-S-V-A-V-A-V-A-V-V-L-A-F-I-C-L-Q-E-S-S-A-V-P-A-N-E-E-Q-E-L-E-Q-Q-I-Y-F-A-D-P-E-M-P-V-E-S-C-K-M-P-Y-Y-M-R-E-N-R-Q-G-S-P-A-R-C-R-F-C-C-R-C-C-P-R-M-R-G-C-G-I-C-C-R-F |
### FUNCTION Component of the biogenesis of lysosome-related organelles complex-1 ### SEQUENCE -M-L-T-S-M-V-K-E-H-H-K-E-Q-A-K-R-K-Q-E-Q-E-V-R-R-K-E-A-I-E-A-S-N-E-L-T-Q-S-L-V-D-T-L-N-V-G-V-A-Q-A-Y-L-N-Q-K-R-L-D-A-E-A-K-Q-L-H-L-G-A-T-N-F-A-K-Q-T-H-Q-W-L-Q-L-I-D-Q-F-S-T-A-L-K-D-L-G-D-V-E-N-W-A-R-S-I-E-G-D-M-H-T-I-N-Q-T-L-E-L-A-Y-K-A-S-R-A-T-Q-T-S-S-G-A-G-T-S-L-E-A-S-T-S-A-S-A-S-A-N-P-S-A-T |
### FUNCTION Associates with spermatozoa in the epididymal fluid but does not bind tightly to them Binds both all-trans and 13-cis retinoic acid May act as a retinoid carrier protein which is required for epididymal function and/or sperm maturation ### SEQUENCE -M-C-S-V-A-R-H-M-E-S-I-M-L-F-T-L-L-G-L-C-V-G-L-A-A-G-T-E-A-A-V-V-K-D-F-D-V-N-K-F-L-G-F-W-Y-E-I-A-L-A-S-K-M-G-A-Y-G-L-A-H-K-E-E-K-M-G-A-M-V-V-E-L-K-E-N-L-L-A-L-T-T-T-Y-Y-N-E-G-H-C-V-L-E-K-V-A-A-T-Q-V-D-G-S-A-K-Y-K-V-T-R-I-S-G-E-K-E-V-V-V-V-A-T-D-Y-M-T-Y-T-V-I-D-I-T-S-L-V-A-G-A-V-H-R-A-M-K-L-Y-S-R-S-L-D-N-N-G-E-A-L-N-N-F-Q-K-I-A-L-K-H-G-F-S-E-T-D-I-H-I-L-K-H-D-L-T-C-V-N-A-L-Q-S-G-Q-I |
### FUNCTION Catalyzes several different glutathione-dependent reactions Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene ### SEQUENCE -M-A-G-D-S-S-L-L-A-A-V-S-L-L-S-A-C-Q-Q-S-Y-F-A-W-R-V-G-R-A-R-L-K-H-K-I-A-P-P-A-V-T-G-P-L-E-F-E-R-I-F-R-A-Q-Q-N-S-L-E-F-Y-P-V-F-I-V-M-L-W-M-A-G-W-Y-F-N-Q-V-F-A-A-C-L-G-L-L-Y-I-Y-A-R-H-K-Y-F-W-G-Y-A-E-A-A-E-K-R-I-T-G-F-R-L-S-L-G-I-L-T-L-L-P-V-L-A-V-L-G-V-A-S-R-F-L-N-E-Y-L-D-F-H-V-A-K-K-L-R-K-P-F |
### FUNCTION May be involved in ciliary biogenesis or function ### SEQUENCE -M-A-G-T-V-L-G-V-G-A-G-V-F-I-L-A-L-L-W-V-A-V-L-L-L-C-V-L-L-S-R-A-S-G-A-A-R-F-S-V-I-F-L-F-F-G-A-V-I-I-T-S-V-L-L-L-F-P-R-A-G-E-F-P-A-P-E-V-E-V-K-I-V-D-D-F-F-I-G-R-Y-V-L-L-A-F-L-S-A-I-F-L-G-G-L-F-L-V-L-I-H-Y-V-L-E-P-I-Y-A-K-P-L-H-S-Y |
### FUNCTION Together with MWL2, contributes to secondary cell wall biology, specifically lignin biosynthesis ### SEQUENCE -M-F-I-F-L-F-G-L-A-A-F-F-L-C-L-S-A-E-F-Q-K-A-K-A-L-L-R-A-Q-V-F-L-K-G-K-D-L-K-W-D-G-E-S-C-Y-L-P-E-N-R-A-F-G-L-G-I-A-A-L-V-C-V-S-V-A-Q-I-V-G-N-V-V-I-C-R-G-F-T-K-T-D-K-T-R-T-T-I-F-C-I-I-L-L-L-F-S-W-V-N-F-A-V-A-V-T-L-I-S-V-G-A-S-M-N-R-E-Q-I-Y-G-K-G-W-L-N-R-E-C-Y-L-V-K-D-G-V-F-A-A-S-G-F-L-S-V-T-T-M-A-A-I-L-G-A-F-A-F-K-V-K-P-S-L-Q-V-E-N-H-D-K-R-H-T-Q-N-V |
### FUNCTION Plays an essential role in the viral genome replication Participates, together with NSP2, in the formation of viral factories which are large inclusions in the host cytoplasm where replication intermediates are assembled and viral RNA replication takes place Orchestrates the recruitment of viroplasmic proteins such as capsid proteins to these factories ### SEQUENCE -M-S-L-S-I-D-V-T-S-L-P-S-I-P-S-T-I-Y-K-N-E-S-S-S-T-T-S-T-L-S-G-K-S-I-G-R-S-E-Q-Y-I-S-P-D-A-E-A-F-N-K-Y-M-L-S-K-S-P-E-D-I-G-P-S-D-S-A-S-N-D-P-L-T-S-F-S-I-R-S-N-A-V-K-T-N-A-D-A-G-V-S-M-D-S-S-A-Q-S-R-P-S-S-N-V-G-C-D-Q-V-D-F-S-L-N-K-G-L-K-V-K-A-N-L-D-S-S-I-S-I-S-T-D-T-K-K-E-K-S-K-Q-N-H-K-S-R-K-H-Y-P-R-I-E-A-E-S-D-S-D-D-Y-V-L-D-D-S-D-S-D-D-G-K-C-K-N-C-K-Y-K-K-K-Y-F-A-L-R-M-R-M-K-Q-V-A-M-Q-L-I-E-D-L |
### FUNCTION Protein tyrosine phosphatase which stimulates progression from G1 into S phase during mitosis Enhances cell proliferation, cell motility and invasive activity, and promotes cancer metastasis May be involved in the progression of cardiac hypertrophy by inhibiting intracellular calcium mobilization in response to angiotensin II ### SEQUENCE -M-A-R-M-N-R-P-A-P-V-E-V-S-Y-K-N-M-R-F-L-I-T-H-N-P-T-N-A-T-L-S-S-F-I-E-D-L-K-K-Y-G-A-T-T-V-V-R-V-C-E-V-T-Y-D-K-A-P-L-E-K-D-G-I-T-V-V-D-W-P-F-D-D-G-A-P-P-P-G-K-V-V-E-D-W-L-S-L-L-K-N-K-F-C-D-D-P-G-S-C-V-A-V-H-C-V-A-G-L-G-R-A-P-V-L-V-A-L-A-L-I-E-S-G-M-K-Y-E-D-A-I-Q-F-I-R-Q-K-R-R-G-A-I-N-S-K-Q-L-T-Y-L-E-K-Y-R-P-K-Q-R-L-R-F-K-D-P-H-A-H-K-T-K-C-C-I-M |
### FUNCTION Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 ### SEQUENCE -M-M-K-L-K-S-N-Q-T-R-T-Y-D-G-D-G-Y-K-K-R-A-A-C-L-C-F-R-S-E-S-E-E-E-V-L-L-V-S-S-S-R-H-P-D-R-W-I-V-P-G-G-G-M-E-P-E-E-E-P-G-T-A-A-V-R-E-V-C-E-E-A-G-V-K-G-T-L-G-R-L-V-G-I-F-E-N-Q-E-R-K-H-R-T-Y-V-Y-V-L-I-V-T-E-V-L-E-D-W-E-D-S-V-S-I-G-R-K-R-E-W-F-K-I-E-D-A-I-N-V-L-Q-C-H-K-P-V-Q-A-S-Y-F-E-T-L-R-Q-G-Y-S-A-N-N-G-T-P-L-V-A-P-T-Y-S-V-S-A-Q-S-S-M-P-G-I-R |
### FUNCTION Involved in the hydrolysis of the beta-gamma-phosphoanhydride linkage of triphosphate-containing substrates , however it can also catalyze the hydrolysis of ATP to ADP and phosphate It can use ribonucleotides such as GTP, CTP, or UTP and deoxynucleotides such as dATP, dGTP, dCTP, and dTTP ### SEQUENCE -M-G-K-E-I-E-K-K-F-I-V-S-G-D-A-Y-K-S-L-A-K-G-V-L-Y-R-Q-G-Y-I-F-F-D-K-D-K-S-V-R-V-R-V-F-N-D-K-G-Y-L-T-V-K-G-T-S-T-G-I-S-R-L-E-Y-E-Y-E-I-P-V-G-E-A-N-E-I-L-E-Y-L-C-E-K-P-V-I-E-K-L-R-Y-K-F-Q-F-E-G-F-T-W-E-V-D-E-F-L-G-E-N-E-G-L-V-I-A-E-I-E-L-P-D-E-N-A-V-F-K-K-P-D-W-I-G-R-E-V-T-G-D-P-R-Y-L-N-S-N-L-V-K-N-P-Y-K-N-F-K-E |
### FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry After attaching to the cell surface, the virion enters the cell by endocytosis Acidification of the endosome triggers M2 ion channel activity The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein , and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur Also plays a role in viral proteins secretory pathway Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation ### SEQUENCE -M-S-L-L-T-E-V-E-T-P-I-R-N-E-W-G-C-R-C-N-D-S-S-D-P-L-V-V-A-A-S-I-I-G-I-V-H-L-I-L-W-I-I-D-R-L-F-F-K-C-I-Y-R-I-F-K-H-G-L-K-R-G-P-S-T-E-G-V-P-E-S-M-R-E-E-Y-R-E-E-Q-Q-N-A-V-D-A-D-E-G-H-F-V-S-I-E-L-E |
### FUNCTION Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3 ### SEQUENCE -M-G-A-R-D-C-T-P-L-L-M-L-S-F-L-L-F-P-L-G-F-P-V-L-G-A-P-A-R-L-I-C-D-S-R-V-L-E-R-Y-I-L-E-A-R-E-A-E-N-A-T-M-G-C-A-E-G-C-S-F-N-E-N-I-T-V-P-D-T-K-V-N-F-Y-A-W-K-R-M-E-V-Q-Q-Q-A-Q-E-V-W-Q-G-L-A-L-L-S-E-A-I-L-R-G-Q-A-L-L-A-N-A-S-Q-P-C-E-A-L-R-L-H-V-D-K-A-V-S-G-L-R-S-L-T-S-L-L-R-A-L-G-A-Q-K-E-A-I-S-L-P-D-A-T-P-S-A-A-P-L-R-A-F-T-V-D-A-L-S-K-L-F-R-I-Y-S-N-F-L-R-G-K-L-T-L-Y-T-G-E-A-C-R-R-G-D-R |
### FUNCTION Endogenous F ### SEQUENCE -M-A-R-L-L-L-R-R-G-F-F-S-S-H-I-R-M-S-S-D-Q-L-G-E-L-G-T-G-A-G-K-G-G-G-G-G-G-S-V-R-A-A-G-G-S-F-G-R-R-E-A-A-E-E-E-R-Y-F-R-Q-K-E-R-E-Q-L-A-A-L-K-N-H-H-E-E-E-I-D-H-H-K-K-E-I-E-R-L-Q-R-E-I-D-R-H-K-G-K-I-R-K-L-K-H-D-D |
### FUNCTION Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors ### SEQUENCE -M-G-G-L-E-P-C-S-R-L-L-L-L-P-L-L-L-A-V-G-G-L-R-P-V-Q-A-Q-A-Q-S-D-C-S-C-S-T-V-S-P-G-V-L-A-G-I-V-M-G-D-L-V-L-T-V-L-I-A-L-A-V-Y-F-L-G-R-L-V-H-R-G-R-G-A-A-E-A-A-T-R-K-Q-R-I-T-E-T-E-S-P-Y-Q-E-L-Q-G-Q-R-S-D-V-Y-S-D-L-N-M-Q-R-P-Y-Y-K |
### FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry After attaching to the cell surface, the virion enters the cell by endocytosis Acidification of the endosome triggers M2 ion channel activity The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein , and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur Also plays a role in viral proteins secretory pathway Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation ### SEQUENCE -M-S-L-L-T-E-V-E-T-P-I-R-N-E-W-G-C-R-C-N-D-S-S-D-P-L-V-V-A-A-S-I-I-G-I-L-H-L-I-L-W-I-L-D-R-L-F-F-K-C-I-Y-R-L-F-K-H-G-L-K-R-G-P-S-T-E-G-V-P-E-S-M-R-E-E-Y-R-K-E-Q-Q-N-A-V-D-A-D-D-S-H-F-V-N-I-E-L-E |
### FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry After attaching to the cell surface, the virion enters the cell by endocytosis Acidification of the endosome triggers M2 ion channel activity The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein , and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur Also plays a role in viral proteins secretory pathway Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation ### SEQUENCE -M-S-L-L-T-E-V-E-T-P-I-R-N-E-W-G-C-R-C-N-D-S-S-D-P-L-V-V-A-A-S-I-I-G-I-L-H-L-I-L-W-I-L-D-R-L-F-F-K-C-I-Y-R-L-F-K-H-G-L-K-R-G-P-S-T-E-G-V-P-E-S-M-R-E-E-Y-R-E-E-Q-Q-N-A-V-D-A-D-D-G-H-F-V-S-I-E-L-E |
### FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry After attaching to the cell surface, the virion enters the cell by endocytosis Acidification of the endosome triggers M2 ion channel activity The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein , and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur Also plays a role in viral proteins secretory pathway Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation ### SEQUENCE -M-S-L-L-T-E-V-E-T-P-I-R-N-E-W-G-C-R-C-N-G-S-S-D-P-L-V-I-A-A-N-I-I-G-I-L-H-L-I-L-W-I-L-D-R-L-F-F-K-C-I-Y-R-L-F-E-Y-G-L-K-R-G-P-S-T-E-G-V-P-E-S-M-R-E-E-Y-R-K-E-Q-Q-S-A-V-D-A-D-D-G-H-F-V-S-I-E-L-E |
### FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry After attaching to the cell surface, the virion enters the cell by endocytosis Acidification of the endosome triggers M2 ion channel activity The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein , and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur Also plays a role in viral proteins secretory pathway Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation ### SEQUENCE -M-S-L-L-T-E-V-E-T-P-I-R-N-E-W-G-C-R-C-N-D-S-S-D-P-L-V-V-A-A-S-I-I-G-I-L-H-L-I-L-W-I-L-D-R-L-F-F-K-C-I-Y-R-L-F-K-H-G-L-K-R-G-P-S-T-E-G-V-P-E-S-M-R-E-E-Y-R-E-E-Q-Q-N-A-V-D-A-D-D-G-H-F-V-S-I-E-L-E |
### FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry After attaching to the cell surface, the virion enters the cell by endocytosis Acidification of the endosome triggers M2 ion channel activity The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein , and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur Also plays a role in viral proteins secretory pathway Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation ### SEQUENCE -M-S-L-L-T-E-V-E-T-P-I-R-N-E-W-G-C-R-C-N-D-S-S-D-P-L-V-V-A-A-S-I-I-G-I-L-H-L-I-L-W-I-L-D-R-L-F-F-K-C-I-Y-R-L-F-K-H-G-L-K-R-G-P-S-T-E-G-V-P-E-S-M-R-E-E-Y-R-K-E-Q-Q-S-A-V-D-A-D-D-S-H-F-V-N-I-E-L-E |
### FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry After attaching to the cell surface, the virion enters the cell by endocytosis Acidification of the endosome triggers M2 ion channel activity The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein , and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur Also plays a role in viral proteins secretory pathway Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation ### SEQUENCE -M-S-L-L-T-E-V-E-T-P-I-R-N-E-W-G-C-R-C-N-G-S-S-D-P-L-V-I-A-A-S-I-I-G-I-L-H-L-I-L-W-I-L-D-R-L-L-F-K-C-I-Y-R-R-F-K-Y-G-L-K-R-G-P-S-T-E-G-V-P-E-S-M-R-E-E-Y-R-K-E-Q-Q-S-A-V-D-A-D-D-G-H-F-V-N-I-E-P-E |
### FUNCTION Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca levels in elongated spermatids May play a role in germ cell differentiation ### SEQUENCE -M-D-K-V-Q-Y-L-T-R-S-A-I-R-R-A-S-T-I-E-M-P-Q-Q-A-R-Q-N-L-Q-N-L-F-I-N-F-C-L-I-S-I-C-L-L-L-I-C-I-I-V-M-L-L |
### FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry After attaching to the cell surface, the virion enters the cell by endocytosis Acidification of the endosome triggers M2 ion channel activity The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein , and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur Also plays a role in viral proteins secretory pathway Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation ### SEQUENCE -M-S-L-L-T-E-V-E-T-P-I-R-N-E-W-G-C-R-C-N-D-S-S-D-P-L-I-I-A-A-S-V-V-G-I-L-H-L-I-L-W-I-L-D-R-L-F-F-K-C-I-Y-R-L-F-K-H-G-L-K-R-G-P-S-T-E-G-V-P-E-S-M-R-E-E-Y-R-K-E-Q-Q-S-A-V-D-A-D-D-S-H-F-V-N-I-E-L-E |
### FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry After attaching to the cell surface, the virion enters the cell by endocytosis Acidification of the endosome triggers M2 ion channel activity The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein , and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur Also plays a role in viral proteins secretory pathway Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation ### SEQUENCE -M-S-L-L-T-E-V-E-T-P-I-R-N-E-W-G-C-R-C-N-D-S-S-D-P-L-V-V-A-A-N-I-I-G-I-L-H-L-I-L-W-I-L-D-R-L-F-F-K-C-I-Y-R-L-F-K-H-G-L-K-R-G-P-S-T-E-G-V-P-E-S-M-R-E-E-Y-R-K-E-Q-Q-S-A-V-D-A-D-D-S-H-F-V-N-I-E-L-E |
### FUNCTION Forms a proton-selective ion channel that is necessary for the efficient release of the viral genome during virus entry After attaching to the cell surface, the virion enters the cell by endocytosis Acidification of the endosome triggers M2 ion channel activity The influx of protons into virion interior is believed to disrupt interactions between the viral ribonucleoprotein , and lipid bilayers, thereby freeing the viral genome from interaction with viral proteins and enabling RNA segments to migrate to the host cell nucleus, where influenza virus RNA transcription and replication occur Also plays a role in viral proteins secretory pathway Elevates the intravesicular pH of normally acidic compartments, such as trans-Golgi network, preventing newly formed hemagglutinin from premature switching to the fusion-active conformation ### SEQUENCE -M-S-L-L-T-E-V-E-T-P-I-R-N-E-W-G-C-R-C-N-D-S-S-D-P-L-V-V-A-A-S-I-I-G-I-L-H-L-I-L-W-I-L-D-R-L-F-F-K-C-I-Y-R-L-F-K-H-G-L-K-R-G-P-S-T-E-G-V-P-E-S-M-R-E-E-Y-R-K-E-Q-Q-S-A-V-D-A-D-D-S-H-F-V-N-I-E-L-E |
### FUNCTION Heterodimer slightly affects neuromuscular transmission acting presynaptically It has a low catalytic activity, a low anticoagulant activity and weakly inhibits ADP-induced platelet aggregation ### SEQUENCE -M-R-T-L-W-I-V-A-V-C-L-I-G-V-E-G-N-L-F-Q-F-G-D-M-I-L-Q-K-T-G-K-E-A-V-H-S-Y-A-I-Y-G-C-Y-C-G-W-G-G-Q-G-R-A-Q-D-A-T-D-R-C-C-F-A-Q-D-C-C-Y-G-R-V-N-D-C-N-P-K-T-A-T-Y-T-Y-S-F-E-N-G-D-I-V-C-G-D-N-D-L-C-L-R-A-V-C-E-C-D-R-A-A-A-I-C-L-G-E-N-V-N-T-Y-D-K-N-Y-E-Y-Y-S-I-S-H-C-T-E-E-S-E-Q-C |
### FUNCTION Possesses antifungal activity against Foxysporum, Treesei and Calbicans Weakly inhibits the aspartic acid protease pepsin activity ### SEQUENCE -M-K-T-M-R-M-N-S-A-F-I-L-A-F-A-L-A-A-A-M-L-I-L-T-E-A-A-N-T-A-F-V-S-S-A-C-N-T-Q-K-I-P-S-G-S-P-F-N-R-N-L-R-A-M-L-A-D-L-R-Q-N-T-A-F-S-G-Y-D-Y-K-T-S-R-A-G-S-G-G-A-P-T-A-Y-G-R-A-T-C-K-Q-S-I-S-Q-S-D-C-T-A-C-L-S-N-L-V-N-R-I-F-S-I-C-N-N-A-I-G-A-R-V-Q-L-V-D-C-F-I-Q-Y-E-Q-R-S-F |
### FUNCTION Modulates intracellular Mg May inhibit FtsH proteolysis of MgtA ### SEQUENCE -M-L-G-N-M-N-V-F-M-A-V-L-G-I-I-L-F-S-G-F-L-A-A-Y-F-S-H-K-W-D-D |
### FUNCTION Functions as a key regulator of cell membrane composition by regulating protein surface expression Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion Regulates transepithelial migration of neutrophils into the alveolar lumen, potentially via mediation of cell surface expression of adhesion markers and lipid raft formation ### SEQUENCE -M-L-V-L-L-A-F-I-I-A-F-H-I-T-S-A-A-L-L-F-I-A-T-I-D-N-A-W-W-V-G-D-E-F-F-A-D-V-W-R-I-C-T-N-N-T-N-C-T-V-I-N-D-S-F-Q-E-Y-S-T-L-Q-A-V-Q-A-T-M-I-L-S-T-I-L-C-C-I-A-F-F-I-F-V-L-Q-L-F-R-L-K-Q-G-E-R-F-V-L-T-S-I-I-Q-L-M-S-C-L-C-V-M-I-A-A-S-I-Y-T-D-R-R-E-D-I-H-H-K-N-A-K-F-Y-P-V-T-R-E-G-S-Y-G-Y-S-Y-I-L-A-W-V-A-F-A-C-T-F-I-S-G-M-M-Y-L-I-L-R-K-R-K |
### FUNCTION Membrane-anchoring subunit of succinate dehydrogenase ### SEQUENCE -M-A-T-L-W-R-L-S-V-L-C-G-A-R-G-G-G-A-L-V-L-R-T-S-V-V-R-P-A-H-V-S-A-F-L-Q-D-R-H-T-P-G-W-C-G-V-Q-H-I-H-L-S-P-S-H-Q-A-S-S-K-A-A-S-L-H-W-T-G-E-R-V-V-S-V-L-L-L-G-L-L-P-A-A-Y-L-N-P-C-S-A-M-D-Y-S-L-A-A-A-L-T-L-H-G-H-W-G-I-G-Q-V-V-T-D-Y-V-R-G-D-A-L-Q-K-V-A-K-A-G-L-L-A-L-S-A-F-T-F-A-G-L-C-Y-F-N-Y-H-D-V-G-I-C-K-A-V-A-M-L-W-K-L |
### FUNCTION Ribonuclease Angiogenic Plays a role in host defense Exhibits strong antibacterial activity against Gram-negative bacteria but mild antibacterial activity against Gram-positive bacteria The RNase activity is not required for the bactericidal activity ### SEQUENCE -M-G-I-H-Q-C-T-A-V-V-L-L-L-L-C-A-S-L-S-T-Y-G-Q-P-A-E-I-R-R-R-Y-E-H-F-L-T-Q-H-V-Y-G-G-I-T-E-Q-T-C-D-R-V-M-R-Q-R-R-I-T-R-F-P-T-G-N-D-C-K-E-V-N-T-F-I-Q-A-N-G-N-H-V-R-T-V-C-T-G-G-G-T-R-Q-T-D-N-R-D-L-Y-M-S-N-N-Q-F-T-V-I-T-C-T-L-R-S-G-E-R-H-P-N-C-R-Y-R-G-K-E-S-S-R-K-I-V-V-A-C-E-G-E-W-P-T-H-Y-E-K-G-V-I-V |
### FUNCTION Seems to have a peripheral vasodepressor effect and a central vasopressor effect ### SEQUENCE -M-T-A-H-I-L-L-L-W-L-F-A-S-S-I-L-G-D-P-D-S-A-G-R-L-T-R-H-Q-V-S-L-K-S-G-R-L-C-S-L-G-T-C-Q-T-H-R-L-P-E-I-I-Y-W-L-R-S-A-S-T-K-E-L-S-G-K-A-G-R-K-P-Q-D-P-Y-S-Y-G-R-R-R-R-R-R-R-R-R-R-E-A-R-L-L-R-R-L-Q-D-P-S-L-R-R-A-Q-L-A-G |
### FUNCTION Catalyzes the covalent attachment of ubiquitin to other proteins Regulates pronephros development, possibly by promoting ubiquitination and thus inactivation or degradation of map3k10/mlk2 ### SEQUENCE -M-A-L-K-R-I-Q-K-E-L-M-D-L-Q-R-D-P-P-A-Q-C-S-A-G-P-V-G-E-D-L-F-H-W-Q-A-T-I-M-G-P-N-D-S-P-F-Q-G-G-V-F-F-L-T-I-H-F-P-T-D-Y-P-F-K-P-P-K-V-A-F-T-T-K-I-Y-H-P-N-I-N-S-N-G-S-I-C-L-D-I-L-R-S-Q-W-S-P-A-L-T-V-S-K-V-L-L-S-I-C-S-L-L-C-D-P-N-P-D-D-P-L-V-P-E-I-A-H-T-Y-K-A-D-R-E-K-Y-N-R-L-A-R-E-W-T-Q-K-Y-A-M |
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