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258/TumorCenter_CD3_block16_x3_y5_patient258_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 11943.7,
+    "Centroid Y µm": 12693.3,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

258/ops_codes.txt

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+Partielle Resektion der Zunge durch Pharyngotomie mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-251.22 ] Transorale Resektion des Mundbodens mit Rekonstruktion mit freiem mikrovaskulär-anastomosiertem Transplantat[5-277.02 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Temporäre Tracheotomie[5-311.0 ] Entnahme fasziokutaner Lappen mit mikrovaskulärer Anastomosierung Unterarm[5-858.03 L] Vollhaut Entnahmestelle Leisten- und Genitalregion[5-901.1c ] Vollhautdeckung großflächig Empfängerstelle Unterarm[5-902.68 L] Wechsel vaskuläres Implantat Gefäße onA[5-394.3 ]

259/InvasionFront_CD8_block6_x1_y6_patient259_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4647.5,
+    "Centroid Y µm": 14542.3,
+    "Num Detections": 29200,
+    "Num Negative": 23679,
+    "Num Positive": 5521,
+    "Positive %": 18.91,
+    "Num Positive per mm^2": 1992.0
+  }
+}

259/InvasionFront_CD8_block6_x2_y6_patient259_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7371.1,
+    "Centroid Y µm": 14617.3,
+    "Num Detections": 27658,
+    "Num Negative": 24135,
+    "Num Positive": 3523,
+    "Positive %": 12.74,
+    "Num Positive per mm^2": 1276.6
+  }
+}

259/TumorCenter_CD3_block6_x1_y6_patient259_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3773.0,
+    "Centroid Y µm": 15416.8,
+    "Num Detections": 25672,
+    "Num Negative": 16067,
+    "Num Positive": 9605,
+    "Positive %": 37.41,
+    "Num Positive per mm^2": 3434.3
+  }
+}

259/TumorCenter_CD3_block6_x2_y6_patient259_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6471.6,
+    "Centroid Y µm": 15341.9,
+    "Num Detections": 23778,
+    "Num Negative": 19108,
+    "Num Positive": 4670,
+    "Positive %": 19.64,
+    "Num Positive per mm^2": 1725.8
+  }
+}

259/TumorCenter_CD8_block6_x1_y6_patient259_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3698.0,
+    "Centroid Y µm": 15666.7,
+    "Num Detections": 30206,
+    "Num Negative": 26419,
+    "Num Positive": 3787,
+    "Positive %": 12.54,
+    "Num Positive per mm^2": 1318.6
+  }
+}

259/TumorCenter_CD8_block6_x2_y6_patient259_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6421.6,
+    "Centroid Y µm": 15666.7,
+    "Num Detections": 24434,
+    "Num Negative": 21770,
+    "Num Positive": 2664,
+    "Positive %": 10.9,
+    "Num Positive per mm^2": 968.68
+  }
+}

259/history_text.txt

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+Condition after panendoscopy and confirmed level II squamous cell carcinoma on the right. After performing a PET-CT, the right tonsil lobe is more luminous and on presentation at the tumor conference a tonsillectomy on the right side with frozen section and neck completion is recommended. In case of negative histology, completion of the CUP panendoscopy. Mirror findings revealed a hard palpable mass in the right tonsil lobe, mucosa otherwise without irritation. Therefore indication for the above-mentioned procedure.

259/icd_codes.txt

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+Karzinom Tonsille mehrere Teilbereiche überlappend[C09.8 R] Halslymphknotenmetastasen[C77.0 R]

259/ops_codes.txt

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+Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 R]

259/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2018,
+  "age_at_initial_diagnosis": 64,
+  "sex": "male",
+  "smoking_status": "former",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 11,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

259/patient_pathological_data.json

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+{
+  "patient_id": "259",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT1",
+  "pN_stage": "pN1",
+  "grading": "hpv_association_p16",
+  "hpv_association_p16": "positive",
+  "number_of_positive_lymph_nodes": 1.0,
+  "number_of_resected_lymph_nodes": 16,
+  "perinodal_invasion": "no",
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "<0.1",
+  "histologic_type": "SCC_Conventional-NonKeratinizing",
+  "infiltration_depth_in_mm": NaN
+}

259/surgery_description.txt

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+Tumor tonsillectomy, Completion of right neck dissection

259/surgery_report.txt

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+After the team time-out, intubation by the anesthesia colleagues. Head positioning by the surgeon. Entering with the tonsil retractor. On palpation, the tonsil on the right is very hard. Therefore indication for tumor tonsillectomy on the right side. After medialization with forceps, resection of the right tonsil with sufficient safety distance and removal of a mucosal portion of the anterior and posterior palatal arch. Perform using the dissection technique, deep to the base of the tongue. Here, set down after focal bipolar coagulation. Taking marginal samples from the anterior palatal arch and the posterior palatal arch, as well as from the base of the wound and the base of the tongue, which are sent for histological assessment and frozen section. From the frozen section diagnosis, the tumor specimen is R0-resected and the marginal specimens are also clear on all sides. Transition to neck dissection on the right side. After injection of 10 ml Ultracaine with Suprarenin, sterile draping. Additional application of a skin film and marking of the landmarks and the incision in extension of the old scar. Incision and dissection up to the platysma. Exposure of the anterior margin of the sternocleidomastoid. The tissue is heavily scarred, especially cranially, so start on the caudal side in level IV. First, expose the omohyoid muscle as the border of the neck dissection. Dissection of the anterior part of the sternocleidomastoid and dissection of the internal jugular vein into the caudal scarred tissue. Detachment of the vein and removal of the neck preparation from caudal to cranial, by detaching the scarred cords and identification of the already exposed accessorius nerve. The hypoglossal nerve can also be seen on the lower edge of the digaster venter anterior muscle. Exposure of the capsule of the submandibular glans and the plexus branches. Now resection of scar tissue and the neck preparation with evacuation of regions Ib, IIa, IIb, III, IV and Va and removal of the same while protecting the exposed nerves. Re-inspection of the wound. Irrigation with H2O2 and Ringer. Insertion of a miniredon. There is no evidence of further bleeding. Two-layer wound closure in the usual manner. Re-inspection of the tonsillar lobe on the right. There is no evidence of further bleeding and the procedure is completed without complications.

260/InvasionFront_CD3_block14_x1_y6_patient260_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4572.6,
+    "Centroid Y µm": 18540.2,
+    "Num Detections": 17823,
+    "Num Negative": 15296,
+    "Num Positive": 2527,
+    "Positive %": 14.18,
+    "Num Positive per mm^2": 1246.3
+  }
+}

260/InvasionFront_CD3_block14_x2_y6_patient260_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7146.2,
+    "Centroid Y µm": 18690.1,
+    "Num Detections": 16907,
+    "Num Negative": 15573,
+    "Num Positive": 1334,
+    "Positive %": 7.89,
+    "Num Positive per mm^2": 669.17
+  }
+}

260/InvasionFront_CD8_block14_x1_y6_patient260_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4772.5,
+    "Centroid Y µm": 14492.3,
+    "Num Detections": 17158,
+    "Num Negative": 14081,
+    "Num Positive": 3077,
+    "Positive %": 17.93,
+    "Num Positive per mm^2": 1556.9
+  }
+}

260/InvasionFront_CD8_block14_x2_y6_patient260_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7221.2,
+    "Centroid Y µm": 14617.3,
+    "Num Detections": 16501,
+    "Num Negative": 14910,
+    "Num Positive": 1591,
+    "Positive %": 9.642,
+    "Num Positive per mm^2": 808.76
+  }
+}

260/TumorCenter_CD3_block14_x1_y6_patient260_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4297.7,
+    "Centroid Y µm": 14867.1,
+    "Num Detections": 15619,
+    "Num Negative": 14044,
+    "Num Positive": 1575,
+    "Positive %": 10.08,
+    "Num Positive per mm^2": 785.75
+  }
+}

260/TumorCenter_CD3_block14_x2_y6_patient260_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6846.4,
+    "Centroid Y µm": 15067.0,
+    "Num Detections": 16353,
+    "Num Negative": 14772,
+    "Num Positive": 1581,
+    "Positive %": 9.668,
+    "Num Positive per mm^2": 760.53
+  }
+}

260/TumorCenter_CD8_block14_x1_y6_patient260_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3548.1,
+    "Centroid Y µm": 15516.8,
+    "Num Detections": 17604,
+    "Num Negative": 16390,
+    "Num Positive": 1214,
+    "Positive %": 6.896,
+    "Num Positive per mm^2": 605.76
+  }
+}

260/TumorCenter_CD8_block14_x2_y6_patient260_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6071.8,
+    "Centroid Y µm": 15541.8,
+    "Num Detections": 18687,
+    "Num Negative": 17480,
+    "Num Positive": 1207,
+    "Positive %": 6.459,
+    "Num Positive per mm^2": 571.65
+  }
+}

260/history_text.txt

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+Patient with histologically proven cT4a cN1 G3 supraglottic laryngeal carcinoma with infiltration of the thyroid cartilage and the arytenoid cartilage on the right side. Now indication for the above-mentioned measures.

260/icd_codes.txt

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+Supraglottisches Karzinom[C32.1 R]

260/ops_codes.txt

@@ -0,0 +1 @@
+Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ] Krikopharyngeale Myotomie[5-290.x ]

260/patient_clinical_data.json

@@ -0,0 +1,18 @@
+{
+  "year_of_initial_diagnosis": 2017,
+  "age_at_initial_diagnosis": 54,
+  "sex": "male",
+  "smoking_status": "non-smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 17,
+  "adjuvant_treatment_intent": null,
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "yes"
+}

260/patient_pathological_data.json

@@ -0,0 +1,20 @@
+{
+  "patient_id": "260",
+  "primary_tumor_site": "Larynx",
+  "pT_stage": "pT4a",
+  "pN_stage": "pN1",
+  "grading": "G3",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": 1.0,
+  "number_of_resected_lymph_nodes": 43,
+  "perinodal_invasion": "no",
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "yes",
+  "resection_status": "R1",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "0",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 16.0
+}

260/surgery_description.txt

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+Laryngectomy, Bilateral neck dissection, Placement of nasogastric tube, Placement of voice prosthesis

260/surgery_report.txt

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+First induction of anesthesia and ventilation of the patient via the existing tracheostoma. Re-intubation of the patient onto a laryngectomy tube and subsequent performance of a laryngoscopy using a Kleinsasser C-tube. This revealed an exophytic, contact-vulnerable mass covering the entire supraglottis on the right side with clear infiltration of the interaryngeal region and the arytenoid region on the right side and infiltration of the vocal fold on the right side. The rest of the endolarynx and the hypopharynx were unremarkable. Subsequently, a nasogastric feeding tube was inserted under visualization in a typical manner. A PEG insertion was deliberately avoided in this session due to the condition after the previous operation and the expected scarred conditions in the abdomen. This should then be inserted by the surgical colleagues. Local anesthesia is then applied cervically ........... submedially. Skin ablation and sterile draping. Skin incision. Dissection of the subcutaneous tissue and the platysma and formation of a subplatysmal apron flap in the typical manner. Exposure and transection of the prelaryngeal muscles in the midline. Exposure of the thyroidithm, which is still present. Dissecting it in the midline. Exposure of the anterior wall of the trachea. Subsequent exposure of the external jugular vein on both sides. Dissection along the anterior border of the sternocleidomastoid muscle on the right side. Exposure and sparing of the auricular nerve. Exposure of the digaster muscle (venter posterior). Exposure of the accessorius nerve and the omohyoid muscle. Exposure of the internal jugular vein, the accessorius nerve and the common carotid artery. Dissection along the cervical vascular sheath from caudal to cranial up to the digaster muscle. Successive removal of the posterior and anterior neck preparation while sparing the above-mentioned structures and the plexus branches. Several suspicious lymph nodes in regions III and IV, which were also removed in the neck preparation. Repositioning of the patient on the left side to perform the neck dissection. Dissection along the anterior edge of the sternocleidomastoid muscle. Exposure and protection of the auricularis magnus nerve. Exposure and ligation of the external jugular vein. Exposure of the accessorius nerve, the posterior venter of the digaster muscle and the omohyoid muscle. Exposure of the internal jugular vein. Exposure of the vagus nerve and the common carotid artery. Dissection along the cervical vascular sheath from caudal to cranial. Successive removal of the posterior and anterior neck preparation while protecting the above-mentioned structures and the plexus branches. Dry conditions on both sides. Subsequent skeletonization of the hyoid bone. Dissection of the infrahyoid musculature. A large part of the sternohyoid muscle and the sternothyroid muscle at the level of the thyroid cartilage is removed with the tumor preparation. Subsequent exposure of the thyroid cartilage. Skeletonization of the same. Scalpel incision along the posterior edge of the thyroid cartilage on both sides and removal of the muscle fibers of the constrictor pharyngis medius muscle on both sides. Sparing of the wall of the piriform sinus on both sides. Subsequent dissection of the hyoid bone from the suprahyoid soft tissue. Dissection in this region and exposure of the free edge of the epiglottis and pharyngotomy. Opening of the pharyngeal lumen. Incision along the lateral edges of the epiglottis and along the aryepiglottic folds on both sides. Strict care is taken to preserve the mucosa of the piriform sinus on both sides as much as possible. Joining of both vertical incisions in the postcricoid area. Separation of the mucosa of the hypopharynx from the laryngeal skeleton and further dissection between the hypopharynx as well as the esophagus and the posterior wall of the trachea. Repeated hemostasis using bipolar coagulation. Deposition of the preparation at the level of the third tracheal cartilage clasp. Hemostasis using bipolar coagulation. Three marginal samples were taken (right piriform sinus, anterior and posterior tracheal margin). All three samples were found to be tumor-free by the pathology colleagues. Subsequently insertion of a size 8 Provox prosthesis in the typical manner. Perform a careful cricopharyngeal myotomy over a distance of 3 cm laterally on the left. Resection of the caudal end of the sternocleidomastoid muscle on both sides. Three-layer pharyngeal suture. Reinforcement of the pharyngeal suture using Tachosil. Suture adaptation of the prelaryngeal musculature. Knockback of the subplatysmal apron flap. Tracheostomy sutures. Two-layer wound closure. Application of a pressure dressing. Re-intubation of the patient to a size 8 tracheostomy tube. Completion of the procedure without complications. Conclusion: Laryngectomy, modified radical neck dissection on both sides, insertion of a size 8 Provox prosthesis, insertion of a nasogastric feeding tube. Please present the patient to our interdisciplinary tumor conference as soon as possible. If adjuvant radiochemotherapy is indicated, a PEG should be inserted by our surgical colleagues due to the patient's condition following previous surgery.  

261/InvasionFront_CD3_block16_x3_y9_patient261_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 11679.7,
+    "Centroid Y µm": 26833.7,
+    "Num Detections": 12866,
+    "Num Negative": 11742,
+    "Num Positive": 1124,
+    "Positive %": 8.736,
+    "Num Positive per mm^2": 525.83
+  }
+}

261/InvasionFront_CD3_block16_x4_y9_patient261_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 14303.6,
+    "Centroid Y µm": 26957.0,
+    "Num Detections": 16612,
+    "Num Negative": 14886,
+    "Num Positive": 1726,
+    "Positive %": 10.39,
+    "Num Positive per mm^2": 773.9
+  }
+}

261/InvasionFront_CD8_block16_x3_y9_patient261_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10671.8,
+    "Centroid Y µm": 22064.7,
+    "Num Detections": 14156,
+    "Num Negative": 13436,
+    "Num Positive": 720,
+    "Positive %": 5.086,
+    "Num Positive per mm^2": 367.42
+  }
+}

261/InvasionFront_CD8_block16_x4_y9_patient261_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13337.3,
+    "Centroid Y µm": 22154.9,
+    "Num Detections": 17895,
+    "Num Negative": 16671,
+    "Num Positive": 1224,
+    "Positive %": 6.84,
+    "Num Positive per mm^2": 553.36
+  }
+}

261/TumorCenter_CD3_block16_x3_y9_patient261_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 11344.0,
+    "Centroid Y µm": 23037.8,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

261/TumorCenter_CD3_block16_x4_y9_patient261_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13967.6,
+    "Centroid Y µm": 23112.8,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

261/TumorCenter_CD8_block16_x3_y9_patient261_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10844.3,
+    "Centroid Y µm": 22962.8,
+    "Num Detections": 12260,
+    "Num Negative": 11612,
+    "Num Positive": 648,
+    "Positive %": 5.285,
+    "Num Positive per mm^2": 404.92
+  }
+}

261/TumorCenter_CD8_block16_x4_y9_patient261_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13492.9,
+    "Centroid Y µm": 22987.8,
+    "Num Detections": 5887,
+    "Num Negative": 5689,
+    "Num Positive": 198,
+    "Positive %": 3.363,
+    "Num Positive per mm^2": 256.5
+  }
+}

261/history_text.txt

@@ -0,0 +1 @@
+In the patient, a progressive mass on the right edge of the tongue was confirmed externally as a G1 differentiated squamous cell carcinoma. Now indication for exclusion of a second malignancy and for enoral tumor resection. Sonography revealed a cN0 neck status.

261/icd_codes.txt

@@ -0,0 +1 @@
+Bösartige Neubildung: Zunge, nicht näher bezeichnet[C02.9 ]

261/ops_codes.txt

@@ -0,0 +1 @@
+Diagnostische Tracheobronchoskopie mit flexiblem Instrument ohne weitere Maßnahmen[1-620.00 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Lokale Exzision am Pharynx[5-292.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Partielle Glossektomie transoral sonstige[5-251.0x ]

261/patient_clinical_data.json

@@ -0,0 +1,18 @@
+{
+  "year_of_initial_diagnosis": 2012,
+  "age_at_initial_diagnosis": 75,
+  "sex": "female",
+  "smoking_status": "non-smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 47,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "brachytherapy",
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": "carboplatin",
+  "adjuvant_radiochemotherapy": "yes"
+}

261/patient_pathological_data.json

@@ -0,0 +1,20 @@
+{
+  "patient_id": "261",
+  "primary_tumor_site": "Oral_Cavity",
+  "pT_stage": "pT1",
+  "pN_stage": "pN3b",
+  "grading": "G1",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": 6.0,
+  "number_of_resected_lymph_nodes": 18,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "yes",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "1.1",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 8.0
+}

261/surgery_description.txt

@@ -0,0 +1 @@
+Partial glossectomy

261/surgery_report.txt

@@ -0,0 +1 @@
+After induction and deepening of the anesthesia by the anesthesia colleagues, perform a rigid tracheoscopy under laryngoscopic control. Easy screening. The trachea is clear and inconspicuous up to the carina, as is the endolarynx including the subglottic region. Problem-free intubation by the surgeon and positioning of the patient. First, flexible esophagogastroscopy was carried out: the gastroscope was inserted under laryngoscopic control. Easy visualization of the stomach. This is inconspicuous and clear. Inspection of the oesophagus on reflection. Here there are ubiquitous small roundish, slightly papillomatous raised changes without suspicious conditions. No further measures required. Otherwise, the esophageal mucosa is free of irritation. Now enter with the small bore tube after inspection of the inconspicuous oral vestibule under dental protection. Inspection of the oral cavity. On the right side, in the area of the middle and transition to the posterior third of the right edge of the tongue, there is an exophytic, slightly exulcerated mass, easily delimited by palpation, approx. 2.5 cm in diameter with an estimated palpatory penetration depth of approx. ˝ cm. On the surface, there are whitish mucosal changes in the area surrounding the tumor, which are not primarily suspicious. The lateral floor of the mouth and the glossotonsillar groove are clear. On further examination, however, there is a circumscribed tear in the right glossotonsillar groove. In dry conditions, no further action is required here. The rest of the tongue is palpatorily and macroscopically free, as are the soft palate, the tonsil region and the base of the tongue. Inspection of the vallecula. A cystic change measuring approx. 1 cm on the median right side is seen here, macroscopically corresponding to a vallecula cyst. This is removed in toto with a double spoon and scissors in the sense of an excisional biopsy. Careful hemostasis using a suprarenal swab and no further measures in dry conditions. The epiglottis is clear. Inspection of the hypopharynx, which can be easily inserted into the tips of the piriform sinus and the esophageal opening and is clear. Adjustment of the endolarynx. Confirmation of inconspicuous findings with a normal glottic plane and inconspicuous supraglottic region. Transoral resection is now performed if the carcinoma is externally confirmed. The open mouth retractor is inserted for this purpose. Snare the free edge of the tongue. Cut around the lesion with a safety margin of approx. 1.5 cm. Also select a macroscopic safety margin of 1.5 cm in depth. Careful preparation with bipolar coagulation and monopolar dissection. The resectate is thread-marked for urgent definitive histology. Due to the whitish, leaking mucosal changes, a covering final margin sample is taken in the area of the free edge of the tongue and the floor of the mouth, which is also thread-marked for urgent histology. Macroscopically wide in sano resection. Meticulous hemostasis. Then adaptation of the wound edges with 3.0 Vicryl if there is a clear defect. Finally, intact conditions and with dry enoral conditions and slender tongue, completion of the procedure without any indication of complications. Conclusion: Macroscopic in sano resection of a cT2 tongue margin carcinoma on the right. If the R0 situation is confirmed histologically, a neck dissection should be performed depending on the histology; in the case of G1 differentiation, a neck dissection may not be necessary, depending on ............, otherwise a selective neck dissection on the right should be performed from an infiltration depth of 4 mm.

262/InvasionFront_CD3_block21_x1_y7_patient262_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 5921.9,
+    "Centroid Y µm": 27535.4,
+    "Num Detections": 19814,
+    "Num Negative": 18371,
+    "Num Positive": 1443,
+    "Positive %": 7.283,
+    "Num Positive per mm^2": 701.84
+  }
+}

262/InvasionFront_CD3_block21_x2_y7_patient262_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 8570.5,
+    "Centroid Y µm": 27810.3,
+    "Num Detections": 19411,
+    "Num Negative": 17174,
+    "Num Positive": 2237,
+    "Positive %": 11.52,
+    "Num Positive per mm^2": 1067.0
+  }
+}

262/InvasionFront_CD8_block21_x1_y7_patient262_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3423.2,
+    "Centroid Y µm": 17215.9,
+    "Num Detections": 17166,
+    "Num Negative": 15889,
+    "Num Positive": 1277,
+    "Positive %": 7.439,
+    "Num Positive per mm^2": 652.74
+  }
+}

262/InvasionFront_CD8_block21_x2_y7_patient262_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6021.8,
+    "Centroid Y µm": 17290.8,
+    "Num Detections": 18695,
+    "Num Negative": 15803,
+    "Num Positive": 2892,
+    "Positive %": 15.47,
+    "Num Positive per mm^2": 1400.2
+  }
+}

262/TumorCenter_CD3_block21_x1_y7_patient262_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3648.1,
+    "Centroid Y µm": 20364.2,
+    "Num Detections": 14241,
+    "Num Negative": 12781,
+    "Num Positive": 1460,
+    "Positive %": 10.25,
+    "Num Positive per mm^2": 796.27
+  }
+}