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737/surgery_description.txt

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+Laser resection, Left-sided neck dissection, Tracheotomy, PEG placement

739/InvasionFront_CD8_block7_x3_y7_patient739_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 11943.7,
+    "Centroid Y µm": 17890.5,
+    "Num Detections": 14661,
+    "Num Negative": 14292,
+    "Num Positive": 369,
+    "Positive %": 2.517,
+    "Num Positive per mm^2": 169.58
+  }
+}

739/InvasionFront_CD8_block7_x4_y7_patient739_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 14717.2,
+    "Centroid Y µm": 18190.4,
+    "Num Detections": 16840,
+    "Num Negative": 15888,
+    "Num Positive": 952,
+    "Positive %": 5.653,
+    "Num Positive per mm^2": 439.25
+  }
+}

739/TumorCenter_CD8_block7_x4_y7_patient739_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13243.0,
+    "Centroid Y µm": 17615.7,
+    "Num Detections": 21792,
+    "Num Negative": 21594,
+    "Num Positive": 198,
+    "Positive %": 0.9086,
+    "Num Positive per mm^2": 80.88
+  }
+}

744/surgery_report.txt

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+Repeated pharyngoscopy and laryngoscopy as well as oral cavity inspection: The tumor can be seen, which is located exophytically in the body of the tongue, does not cross the midline, extends over the floor of the mouth onto the glossoalveolar fold, onto the tonsillar lobe, runs downwards to the end of the tonsil. Infiltration also towards the base of the tongue. This confirms the indication. The next step is transoral tumor resection. The tumor is cut around on all sides with a safety margin of 1-1.5 cm. The anterior palatal arch falls, the posterior palatal arch remains, part of the pharyngeal wall falls, the lower jaw is exposed, the posterior center of the tongue body is resected up to the midline. Parts of the base of the tongue in the upper 2/3 of the base of the tongue are also resected. The lingual nerve is preserved. Removal of the specimen in one piece, suture marking. Extra margin sample basally in the base of the tongue. Send in for frozen section. Preparation in healthy tissue, also marginal sample, thus R0 resection. Careful hemostasis. Measurement of the defect. Neck dissection on the left through <CLINICIAN_NAME> and <CLINICIAN_NAME>: incision in typical manner. Exposure of the sternocleidomastoid muscle, omohyoid muscle, digastric muscle and the infrahyoid musculature. Subsequent clearing of levels II to IV in a typical manner. Exposure of the internal jugular vein, facial vein, exposure of the internal and external carotid artery. Exposure of the accessory nerve, vagus nerve and hypoglossal nerve. Finally, careful hemostasis. Neck dissection on the right side by <CLINICIAN_NAME> and <CLINICIAN_NAME>: Same procedure as on the opposite side. Resection of the submandibular gland and levels Ib and Ia. Exposure and preservation of the facial artery, superior thyroid artery and facial vein with several outlets. Also visualization of the middle thyroid vein. This results in a level I to V evacuation on the left. Branches of the cervical plexus are exposed and preserved. Exposure of all structures as on the left side. Finally, careful hemostasis. Then elevation of the radial flap: marking of the flap length 12 cm to 12.5 cm x 6.5 cm width. Cut around the flap ulnarly, extending it cranially to the olecranon. Lifting of ulnar subfascial. Exposure of the superficial venous system, which is included. Subsequent exposure of the vascular pedicle, which is typically located on the brachioradialis muscle. Then radial incision of the flap. Subfascial elevation. Exposure of the cutaneous nerve to the lateral brachii and preservation. Distal exposure of several veins with ligation. Distal exposure of the end of the vascular pedicle. Exposure of the radial vein and radial artery. Clamp for a few minutes. Saturation always at 100 %. Then cut and treat with puncture ligatures distally and proximally. Lift the flap subfascially along the pedicle. Outgoing vessels are clipped or treated bipolar. Dissection of the vascular pedicle up to the crook of the elbow. Exposure of surface connection, deep venous system. V. cephalica is exposed in a typical manner, as well as larger veins branching off medially, a total of 2 vein ends for the anastomosis. Additional dissection of the confluence, which is also elevated and would be suitable. Exposure of the radial artery up to the entry into the brachial artery. Exposure of the previously outgoing vein and interosseous artery. This is clamped for a few minutes, no change in saturation here. Deposition and clipping or ligation. The flap is then removed and the brachial artery is treated with 6-0 Vascufil sutures. Ligation of the proximal veins. Spraying the flap with heparin solution. To cover the defect on the left forearm, split skin, thickness 0.7-0.8 mm, is removed from the thigh using the dermatome. Split skin is successively incorporated into the defect. Complete, tension-free coverage. Cranial in typical manner. Wound closure in layers. Saturation on the arm always sufficient. Between 95 and 100 %. The superficial skin defect on the thigh is treated with a hydrogel dressing. The forearm is treated with .................-Relex dressing. Then apply compresses and wrap in absorbent cotton. Fit Cramer splint and wrap in elastic bandage in functional site. Application of an arm. Saturation still > 95 %. Subsequent insertion of the radial flap into the enoral mouth defect. This is done using single Vicryl 3-0 button sutures. The flap is sutured successively into the defect without tension, partly with the sutures in place and partly with direct sutures. The flap pedicle is passed through a large tunnel. For this purpose, the digastric muscle was severed and a 3 QF tunnel was created. Tension-free and complete defect coverage. Subsequent vascular suture: facial artery not suitable as the lumen is too small. A. thyroidea superior is selected. Conditioning. Also conditioning of the radial artery. This is thickened in some places in the sense of intimal fibrosis. Fish-mouth-like incision of the superior thyroid artery, thereby equalizing the lumen. Suturing with single 8-button Ethilon sutures. After opening the clamps, good arterial flow and good venous return. Then conditioning of the V. thyroidea media and an outlet from the V. facialis. Conditioning of the 2 outlets from the superficial venous system. One outlet is anastomosed with Coupler 3.0, the second outlet with Coupler 2.5. After opening the clamps, good venous return in each case. Positive smear phenomenon. Finally, clipping of the confluence and several outlets from the superficial venous system close to the outlet. Inspection of the flap. This is well perfused. Then layered wound closure of the skin wound on the right with insertion of 2 flaps after careful hemostasis and irrigation. Layered wound closure of the skin wound on the left after irrigation and hemostasis with insertion of a Redon drainage. On the right, a marking suture is placed above the vascular pedicle for Doppler control. An 8-gauge tracheostomy tube is inserted and fixed with sutures. The flap is inspected again. This is well perfused. The procedure is completed without complications. Patient goes to the intensive care unit postoperatively ventilated. Ventilation for one night. Please continue antibiotics that were started intraoperatively for one week. Heparin, which was started intraoperatively at 500 E/h, should be continued for 5 days. Check the flap clinically and, if necessary, by Doppler according to the scheme for 5 days. Feeding for 10 days via the inserted PEG tube, followed by a gruel and then, if necessary, a diet. Overall cT3 oral cavity oropharyngeal carcinoma on the right. Awaiting the histological findings. Please leave the forearm bandage closed for 1 week, then change the bandage for the first time if there are no unusual findings.

745/TumorCenter_CD8_block3_x6_y10_patient745_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 18515.2,
+    "Centroid Y µm": 26635.9,
+    "Num Detections": 18080,
+    "Num Negative": 15774,
+    "Num Positive": 2306,
+    "Positive %": 12.75,
+    "Num Positive per mm^2": 992.79
+  }
+}

745/icd_codes.txt

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+Bösartige Neubildung: Oropharynx, mehrere Teilbereiche überlappend[C10.8 ] Halslymphknotenmetastasen[C77.0 B]

745/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2016,
+  "age_at_initial_diagnosis": 50,
+  "sex": "female",
+  "smoking_status": "smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 23,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": "fluorouracil + cisplatin",
+  "adjuvant_radiochemotherapy": "yes"
+}

745/patient_pathological_data.json

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+{
+  "patient_id": "745",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT3",
+  "pN_stage": "pN2b",
+  "grading": "G3",
+  "hpv_association_p16": "negative",
+  "number_of_positive_lymph_nodes": 2.0,
+  "number_of_resected_lymph_nodes": 33,
+  "perinodal_invasion": "yes",
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "yes",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "0.5",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 19.0
+}

745/surgery_description.txt

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+Tumor resection, Neck dissection, Defect coverage, Free flap (Radial), PEG placement, Tracheotomy

745/surgery_report.txt

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+Induction of anesthesia and intubation by anesthesia colleagues. Sterile washing and draping of the abdominal area. Placement of a PEG using the thread pull-through method with good diaphanoscopy without any problems. Injection in the neck and sterile washing and draping. Insertion of the mouth blocker and start of transoral tumor resection. There is an exophytic mass in the tonsil lobe, which passes over the glossotonsillar groove to the base and edge of the tongue and the floor of the mouth on the right side. Start of tumor resection in the area of the soft palate with the electric needle. Dissection up to the tonsil bed. The soft tissues of the throat are reached relatively quickly here. Dissection up to the base of the tongue and dissection at the edge of the tongue. Ultimately, the tumor cannot be completely removed transorally, so it is transferred for neck dissection. Creation of an apron flap in the usual manner. Exposure of the sternocleidomastoid muscle, the omohyoid muscle, the digaster and the submandibular gland. Exposure of the cervical vascular sheath and the accessorius and hypoglossal nerves. Then evacuation of the neck levels I b to V a while sparing the plexus branches. Removal of the submandibular gland. Cut through the digastric muscle and enter the oropharynx. Now pull through the tumor and complete the tumor resection from transcervical. Remove marginal samples and send the specimen on cork for histology. All marginal samples are free of tumor and carcinoma in situ. Moderate dysplasia was found in the soft palate area. Further resection is recommended here. This is carried out and sent for final histology. Finally, clearing of level I a on the right side. Neck dissection on the left and tracheotomy by <CLINICIAN_NAME>. Exposure of the anterior border of the sternocleidomastoid muscle and exposure of the omohyoid muscle. Dissection of the omohyoid muscle to the cranial side of the digaster muscle. Exposure of the accessorius nerve. Locate the submandibular gland and expose the gland. Fold up the gland and expose the digaster muscle. Dissection in the direction of the hyoid bone and mastoid. Dissection of the internal jugular vein. Free dissection of the vein from caudal to cranial. Easy dissection and visualization of the facial vein. Locating and preserving the hypoglossal nerve at the jugulofacial angle. Careful removal of the medial neck preparation while preserving all structures. Dissection of the lateral neck preparation and removal of this while preserving the plexus branches. No increased bleeding, no chyle. Tracheotomy: Marking of the landmarks and dissection through the prelaryngeal muscles in the linea alba onto the cricoid cartilage. Push the prelaryngeal musculature to the side. Exposure of the thyroid gland and undermining of the thyroid gland with the Pean clamp. Bipolar coagulation of the thyroid gland and careful transection of the thyroid gland. Move the thyroid gland to the side and expose the trachea. Opening of the trachea between the 2nd and 3rd interspace. Entering the trachea and creating a Björ flap. Suturing of the tracheostoma at the caudal edge. Now hand over the operation to the reconstruction team with <CLINICIAN_NAME>. First measure the required dimensions of the flap, these are max. 12 cm long and 10 cm wide. The flap is then raised on the radialis flap on the left forearm: Mark the flap dimensions according to the required size and three-dimensional configuration. Then recut the flap, initially ulnarly. The incision is extended in the direction of the ulnar flexion. Exposure of the superficial venous system, which is integrated into the flap. Lift the flap initially from the ulnar side. Subsequent incision also from the radial side with subfascial and ulnar elevation of the flap. The lateral antebrachial cutaneous nerve is exposed and preserved as far as possible. Distal exposure of the radial artery, which is clamped off. .................................. Lateral exposure of the superficial venous system up to the crook of the elbow. This shows the cephalic vein with two good ends, a good connection to the deep venous system. Depiction of the deep venous system. Exposure of the vascular pedicle. Subsequent transection of the radial artery with good saturation. This is treated proximally and distally with 4.0 Prolene single-button stitches. Lift the flap subfascially. Outgoing vessels are coagulated or clipped. Dissection up to the crook of the elbow. After clamping, cut the interosseous artery. Exposure of the venous confluence, which is lifted with a total of 2 ends. The veins, which are ligated, are then removed and the artery, which is supplied with a 6.0 Prolene suture in the area of the end of the brachial artery, is removed. Flush the flap with heparin solution. Subsequent insertion of the flap into the defect. Successive suturing of the flap, first from the transcervical and then from the transoral side, partly with the sutures in place using 3.0 Vicryl single-button sutures. The result is a tension-free, complete and anatomically correct reconstruction. Flap pedicle is prepared. The radial artery and 2 ends of the cephalic vein are conditioned, as are the superior thyroid artery, the middle thyroid vein and the external jugular vein. The arteries are sutured using 9.0 Ethilon single-button sutures. The veins are anastomosed using 3 and 2 couplers. Positive smear phenomenon after opening the clamps. Arterial flow after opening the clamp before the vein anastomosis is also regular. Subsequent careful irrigation of the wound area and hemostasis. Wound closure of the neck sides is carried out by suturing the skin on the tracheostoma area and inserting Redon drainage on the left and 2 flaps on the right. The cannula is fixed with sutures. Flap vital after repeated transoral inspection. Completion of the procedure without complications. Patient goes to the intensive care unit for postoperative monitoring. Please continue the antibiotic treatment with Unacid for 1 week. Nutrition via the inserted PEG tube until the 7th-10th day, then gruel and, if necessary, diet build-up. Regular checks of the flap perfusion clinically or via the Doppler in the neck area in the area of the marking threads. Checks according to the schedule for 5 days. Wait for the final histology and presentation at the interdisciplinary tumor conference.

746/InvasionFront_CD8_block4_x1_y12_patient746_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3623.1,
+    "Centroid Y µm": 34894.4,
+    "Num Detections": 26054,
+    "Num Negative": 21796,
+    "Num Positive": 4258,
+    "Positive %": 16.34,
+    "Num Positive per mm^2": 1688.4
+  }
+}

746/InvasionFront_CD8_block4_x2_y12_patient746_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6396.6,
+    "Centroid Y µm": 34931.5,
+    "Num Detections": 27646,
+    "Num Negative": 25731,
+    "Num Positive": 1915,
+    "Positive %": 6.927,
+    "Num Positive per mm^2": 754.89
+  }
+}

746/TumorCenter_CD3_block4_x2_y12_patient746_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6521.5,
+    "Centroid Y µm": 30858.7,
+    "Num Detections": 22066,
+    "Num Negative": 19596,
+    "Num Positive": 2470,
+    "Positive %": 11.19,
+    "Num Positive per mm^2": 1090.9
+  }
+}

746/TumorCenter_CD8_block4_x1_y12_patient746_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3473.2,
+    "Centroid Y µm": 30483.9,
+    "Num Detections": 27105,
+    "Num Negative": 23865,
+    "Num Positive": 3240,
+    "Positive %": 11.95,
+    "Num Positive per mm^2": 1168.2
+  }
+}

746/TumorCenter_CD8_block4_x2_y12_patient746_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6046.8,
+    "Centroid Y µm": 30533.8,
+    "Num Detections": 23331,
+    "Num Negative": 22333,
+    "Num Positive": 998,
+    "Positive %": 4.278,
+    "Num Positive per mm^2": 430.84
+  }
+}

746/history_text.txt

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+The patient has a histologically confirmed cT2 cN2a tongue base carcinoma on the left side. There is a post-panendoscopy in domo <2016>. Histologically a squamous cell carcinoma (G2, p16 positive) was confirmed. In the B-scan sonographic examination of the head and soft tissues of the neck performed by us, a cystic mass in region II on the left shows a cN2a neck status. Based on the diagnosis, the above-mentioned operation is indicated. The patient was informed in detail about the procedure and had sufficient time to ask questions.

746/ops_codes.txt

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+Inzision Zungengrund[5-250.x ] Transorale Tumortonsillektomie[5-281.2 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 4 Regionen[5-403.03 B] Anwendung eines komplexen OP-Roboters (Zusatzkode)[5-987.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte diagnostische Pharyngoskopie[1-611.0 ] Diagnostische Ösophagogastroskopie bei normalem Situs[1-631.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ]

746/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2016,
+  "age_at_initial_diagnosis": 66,
+  "sex": "male",
+  "smoking_status": "non-smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 38,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": "cisplatin",
+  "adjuvant_radiochemotherapy": "yes"
+}

746/patient_pathological_data.json

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+{
+  "patient_id": "746",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT2",
+  "pN_stage": "pN3b",
+  "grading": "hpv_association_p16",
+  "hpv_association_p16": "positive",
+  "number_of_positive_lymph_nodes": 1.0,
+  "number_of_resected_lymph_nodes": 26,
+  "perinodal_invasion": "yes",
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "0.5",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 8.0
+}

746/surgery_description.txt

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+Tumor resection TORS, Bilateral neck dissection, PEG placement, Panendoscopy

746/surgery_report.txt

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+Transfer of the patient to the operating theater. Carry out another panendoscopy. Head declination by the surgeon and insertion with the Kleinsasser tube size C. An approx. 3 cm large, partially exophytic mass is seen extending from the lower tonsil pole into the base of the tongue. The midline is not crossed. The piriform sinus is tumor-free. The other findings in the mirror are unremarkable. Perform a flexible gastroesophagoscopy. The mucosal conditions are also unremarkable here. Insertion of a PEG tube using the thread pull-through method in the usual manner without complications. Insertion of the Spantex. Insertion of the mouth blocker and docking of the robotic arms. Adjustment of the robotic arms and positioning of the tumor under endoscopic control. Start with tumor resection from the cranial part to the caudal side. This is done without further bleeding. Removal of the tumor specimen. Obtain several representative marginal samples from the tumor bed. Sending for frozen section diagnostics: The frozen sections are tumor-free. Repeated site check: dry wound conditions on all sides, no evidence of bleeding. Removal of the robotic arms and completion of the tumor resection without complications. Now injection of Supra and wiping of the neck for neck dissection. Start of neck dissection on the left side. Separation of the skin and subcutaneous tissue as well as the platysma at the anterior margin of the sternocleidomastoid muscle 2 QF below the mandible. Dissection of a subplatysmal flap. Identification of the submandibular gland. Dissection along the muscle in depth down to the deep cervical fascia. The plexus branches of the cervical plexus are spared. Identification of the accessorius nerve. There is a metastasis-like mass lateral to the nerve, adjacent to the digastric muscle. From the underside, the internal jugular vein can be reliably separated from the mass by dissection. The accessory nerve can also be safely removed from the metastasis. There are no signs of infiltration. Now detach the remaining neck preparation from the depths while sparing the plexus branches. Identification of the common carotid artery and the vagus nerve. These can be spared without any problems. Identification of the hypoglossal nerve. This should also be spared. Placement of a 10-gauge Redon drain and two-layer wound closure. Now turn to the right side. Here also incision of the skin and subcutaneous tissue. Incision of the platysma and creation of a platysmal flap. Identification of the submandibular gland. Removal of the submandibular gland from its glandular bed. Identification of the digastric muscle. Identification of the accessorius nerve. Division of the neck preparation on the internal jugular vein. Identification of the vagus nerve and common carotid artery. Detachment of the neck preparation on the right side from the depth while sparing the plexus branches. No metastasis-suspicious nodes are visible on the right side. Completion of the neck dissection without complications. As on the left side, the right side is also irrigated with hydrogen and Ringer. Dry wound conditions at the end of the operation. Placement of a 10-gauge Redon drain and two-layer wound closure. The operation is completed without complications.

747/InvasionFront_CD3_block16_x1_y5_patient747_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4454.5,
+    "Centroid Y µm": 17002.3,
+    "Num Detections": 14000,
+    "Num Negative": 13257,
+    "Num Positive": 743,
+    "Positive %": 5.307,
+    "Num Positive per mm^2": 323.39
+  }
+}

747/InvasionFront_CD3_block16_x2_y5_patient747_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7086.6,
+    "Centroid Y µm": 16923.7,
+    "Num Detections": 22015,
+    "Num Negative": 21432,
+    "Num Positive": 583,
+    "Positive %": 2.648,
+    "Num Positive per mm^2": 231.88
+  }
+}

747/InvasionFront_CD8_block16_x1_y5_patient747_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3483.5,
+    "Centroid Y µm": 12088.0,
+    "Num Detections": 17305,
+    "Num Negative": 16676,
+    "Num Positive": 629,
+    "Positive %": 3.635,
+    "Num Positive per mm^2": 291.79
+  }
+}

747/InvasionFront_CD8_block16_x2_y5_patient747_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6240.3,
+    "Centroid Y µm": 12118.3,
+    "Num Detections": 23988,
+    "Num Negative": 23626,
+    "Num Positive": 362,
+    "Positive %": 1.509,
+    "Num Positive per mm^2": 141.57
+  }
+}

747/TumorCenter_CD3_block16_x1_y5_patient747_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4422.7,
+    "Centroid Y µm": 12393.4,
+    "Num Detections": 21408,
+    "Num Negative": 20229,
+    "Num Positive": 1179,
+    "Positive %": 5.507,
+    "Num Positive per mm^2": 445.28
+  }
+}

747/TumorCenter_CD3_block16_x2_y5_patient747_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 7046.3,
+    "Centroid Y µm": 12568.3,
+    "Num Detections": 23093,
+    "Num Negative": 21623,
+    "Num Positive": 1470,
+    "Positive %": 6.366,
+    "Num Positive per mm^2": 543.21
+  }
+}

747/TumorCenter_CD8_block16_x1_y5_patient747_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3423.2,
+    "Centroid Y µm": 12868.2,
+    "Num Detections": 22311,
+    "Num Negative": 21602,
+    "Num Positive": 709,
+    "Positive %": 3.178,
+    "Num Positive per mm^2": 273.83
+  }
+}

747/TumorCenter_CD8_block16_x2_y5_patient747_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6046.8,
+    "Centroid Y µm": 12893.2,
+    "Num Detections": 25076,
+    "Num Negative": 24670,
+    "Num Positive": 406,
+    "Positive %": 1.619,
+    "Num Positive per mm^2": 153.12
+  }
+}

747/history_text.txt

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+The patient presented with a painful mass on the left edge of the tongue. A biopsy was taken externally, which revealed a G2 squamous cell carcinoma. Hence the indication for the above-mentioned procedure.

747/icd_codes.txt

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+Bösartige Neubildung: Zungenrand[C02.1 ]

747/ops_codes.txt

@@ -0,0 +1 @@
+Inzision erkranktes Gewebe Zungenrand[5-250.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Diagnostische Tracheobronchoskopie mit starrem Instrument ohne weitere Maßnahmen[1-620.10 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Direkte Hypopharyngoskopie[1-611.0 ]

747/patient_clinical_data.json

@@ -0,0 +1,18 @@
+{
+  "year_of_initial_diagnosis": 2013,
+  "age_at_initial_diagnosis": 67,
+  "sex": "female",
+  "smoking_status": "non-smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 11,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "brachytherapy",
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

747/patient_pathological_data.json

@@ -0,0 +1,20 @@
+{
+  "patient_id": "747",
+  "primary_tumor_site": "Oral_Cavity",
+  "pT_stage": "pT1",
+  "pN_stage": "NX",
+  "grading": "G2",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": NaN,
+  "number_of_resected_lymph_nodes": 0,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "yes",
+  "closest_resection_margin_in_cm": "0.2",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 2.0
+}

747/surgery_description.txt

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+Excisional biopsy, Panendoscopy

747/surgery_report.txt

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+First induction of anesthesia by the anesthetist. Then the tracheoscopy is performed. Enter with the 0-degree scope and inspect the vocal folds and trachea up to the carina. Inconspicuous conditions on all sides. Intubation by the surgeon. Entry with the flexible esophagoscope and inspection of the esophagus and stomach. No abnormalities here. Intubation with the Kleinsasser tube and inspection of the oropharynx, tonsil larynx, posterior pharyngeal wall, base of tongue, all unremarkable. Inspection of the hypopharynx and in particular the left side, as the patient reported pain here. Even on close inspection, no mucosal lesion or mass was found. The posterior pharyngeal wall, the hypopharyngeal side walls, the piriform sinuses, the postcricoid region and the esophageal entrance are completely unremarkable. Adjustment of the arytenoid region and inspection of the arytenoid cusps and the interaryngeal region. Inconspicuous on all sides. Inspection of the glottic plane, the pocket folds, morgue sinus, no mass here either. Now insertion of a covered retractor and inspection of the oral cavity. Apart from the mass on the tongue, no other lesion can be seen here either. The mass on the tongue is approx. 0.5 cm in diameter. It is cut around on all sides with a safety margin of 1 cm. The specimen is sent to histology in one piece, marked with a suture. Hemostasis with bipolar coagulation and completion of the procedure.

748/InvasionFront_CD3_block22_x3_y11_patient748_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 11868.7,
+    "Centroid Y µm": 39104.3,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

748/InvasionFront_CD3_block22_x4_y11_patient748_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 14392.4,
+    "Centroid Y µm": 39154.3,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

748/InvasionFront_CD8_block22_x3_y11_patient748_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 14369.3,
+    "Centroid Y µm": 27096.0,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

748/InvasionFront_CD8_block22_x4_y11_patient748_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16807.5,
+    "Centroid Y µm": 27087.7,
+    "Num Detections": 2815,
+    "Num Negative": 2599,
+    "Num Positive": 216,
+    "Positive %": 7.673,
+    "Num Positive per mm^2": 515.58
+  }
+}

748/TumorCenter_CD3_block22_x3_y11_patient748_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10762.6,
+    "Centroid Y µm": 27999.3,
+    "Num Detections": 8433,
+    "Num Negative": 7965,
+    "Num Positive": 468,
+    "Positive %": 5.55,
+    "Num Positive per mm^2": 309.6
+  }
+}

748/TumorCenter_CD3_block22_x4_y11_patient748_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13505.3,
+    "Centroid Y µm": 28010.2,
+    "Num Detections": 19819,
+    "Num Negative": 19372,
+    "Num Positive": 447,
+    "Positive %": 2.255,
+    "Num Positive per mm^2": 202.28
+  }
+}

748/TumorCenter_CD8_block22_x3_y11_patient748_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 12968.1,
+    "Centroid Y µm": 37805.0,
+    "Num Detections": 8332,
+    "Num Negative": 7833,
+    "Num Positive": 499,
+    "Positive %": 5.989,
+    "Num Positive per mm^2": 443.52
+  }
+}

748/TumorCenter_CD8_block22_x4_y11_patient748_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 15666.7,
+    "Centroid Y µm": 37979.9,
+    "Num Detections": 19761,
+    "Num Negative": 18737,
+    "Num Positive": 1024,
+    "Positive %": 5.182,
+    "Num Positive per mm^2": 448.49
+  }
+}

748/history_text.txt

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+Preoperative findings: After partial laryngectomy and radiotherapy in 2006, histologically confirmed tumor in the area of the glottis and subglottis in the sense of a second carcinoma. After appropriate explanation to the patient, indication for surgical intervention. No indication for neck revision in the absence of lymph nodes in the area of both sides of the neck.

748/icd_codes.txt

@@ -0,0 +1 @@
+Subglottisches Karzinom[C32.2 ]

748/ops_codes.txt

@@ -0,0 +1 @@
+Sonstige Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.x1 ] Resektion an der Trachea mit Anlegen eines Tracheostomas[5-314.12 ]