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159/surgery_description.txt

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+Resection, Neck dissection, Tracheotomy, Defect coverage, Free flap (Radial), PEG placement

160/InvasionFront_CD3_block16_x4_y11_patient160_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 14104.6,
+    "Centroid Y µm": 31940.6,
+    "Num Detections": 20418,
+    "Num Negative": 19666,
+    "Num Positive": 752,
+    "Positive %": 3.683,
+    "Num Positive per mm^2": 326.13
+  }
+}

160/InvasionFront_CD8_block16_x3_y11_patient160_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10570.8,
+    "Centroid Y µm": 26977.4,
+    "Num Detections": 19772,
+    "Num Negative": 19451,
+    "Num Positive": 321,
+    "Positive %": 1.624,
+    "Num Positive per mm^2": 147.56
+  }
+}

160/InvasionFront_CD8_block16_x4_y11_patient160_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13080.4,
+    "Centroid Y µm": 26821.0,
+    "Num Detections": 19284,
+    "Num Negative": 19065,
+    "Num Positive": 219,
+    "Positive %": 1.136,
+    "Num Positive per mm^2": 104.75
+  }
+}

160/TumorCenter_CD3_block16_x4_y12_patient160_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13342.9,
+    "Centroid Y µm": 30883.6,
+    "Num Detections": 15487,
+    "Num Negative": 14897,
+    "Num Positive": 590,
+    "Positive %": 3.81,
+    "Num Positive per mm^2": 276.91
+  }
+}

160/TumorCenter_CD8_block16_x3_y11_patient160_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10419.5,
+    "Centroid Y µm": 27910.2,
+    "Num Detections": 15340,
+    "Num Negative": 15069,
+    "Num Positive": 271,
+    "Positive %": 1.767,
+    "Num Positive per mm^2": 160.24
+  }
+}

160/TumorCenter_CD8_block16_x4_y11_patient160_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13317.9,
+    "Centroid Y µm": 27810.3,
+    "Num Detections": 8020,
+    "Num Negative": 6710,
+    "Num Positive": 1310,
+    "Positive %": 16.33,
+    "Num Positive per mm^2": 1240.6
+  }
+}

160/history_text.txt

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+The patient has an unclear change in the right edge of the tongue. A PE had revealed a Cis with transition to an invasive carcinoma. In the interdisciplinary tumor conference, the indication for an excisional biopsy was made.

160/icd_codes.txt

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+Zungenrandkarzinom[C02.1 ]

160/ops_codes.txt

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+Diagnostische Laryngoskopie: Direkt[1-610.0 ] Diagnostische Pharyngoskopie: Direkt[1-611.0 ] Diagnostische Tracheobronchoskopie: Mit starrem Instrument[1-620.1 ] Diagnostische Ösophagogastroskopie[1-631 ] Biopsie an der Zunge durch Inzision[1-541 ] Inzision, Exzision und Destruktion von erkranktem Gewebe der Zunge: Inzision am Zungenrand[5-250.0 ]

160/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2009,
+  "age_at_initial_diagnosis": 48,
+  "sex": "female",
+  "smoking_status": "non-smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 25,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": null,
+  "adjuvant_systemic_therapy": "yes",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "yes"
+}

160/patient_pathological_data.json

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+{
+  "patient_id": "160",
+  "primary_tumor_site": "Oral_Cavity",
+  "pT_stage": "pT2",
+  "pN_stage": "pN0",
+  "grading": "G2",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": 0.0,
+  "number_of_resected_lymph_nodes": 15,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "yes",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "yes",
+  "closest_resection_margin_in_cm": "0.1",
+  "histologic_type": "SCC_Conventional-NonKeratinizing",
+  "infiltration_depth_in_mm": 15.0
+}

160/surgery_description.txt

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+Excision of right tongue margin RF (Radial Forearm) flap, Panendoscopy

160/surgery_report.txt

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+After induction of anesthesia by the anesthesia colleagues, rigid tracheoscopy is performed under laryngoscopic control. This is successful without any problems. Mirroring up to the carina. This is clear on all sides. In the area of the posterior tracheal wall, a small induration or protrusion can be seen paramedian to the left about 5 cm subglottically. This is not exophytic and does not appear primarily suspicious for malignancy. Then problem-free intubation by the surgeon. Positioning by the surgeon. Esophagogastroscopy is performed first. Enter with the gastroscope under laryngoscopic control. Mirroring into the stomach without any problems. Here, food residues are clearly visible, but after aspiration of these, the mucosal conditions are unremarkable on all sides. On endoscopy, clear mucosal changes in the sense of reflux esophagitis are noticeable. Otherwise, however, no exophytic masses. Now enter with the small bore tube. Inspection of the hypopharynx. The hypopharynx is clearly visible up to the esophageal entrance, even the postcricoid region is clear without exophytic masses. No suspicious changes in the area of the base of the tongue, vallecula and epiglottis. Adjustment of the endolarynx. Inconspicuous mucosal conditions without exophytic tumor growth. Inspection of the oral cavity. A coarse, whitish, circumscribed change in the right glossotonsillar groove is seen in the area of the transition to the alveolar ridge anteriorly on the edge of the tongue, the mucosa is slightly reddened and uneven and leads to clearly leukoplakic changes in the area of the edge of the tongue, transitioning to the floor of the mouth, with whitish, non-wipeable coatings. The decision is made to excise the suspicious, indurated mass, which, however, does not move into the base of the tongue on palpation, while at the same time taking the suspicious mucosal changes anteriorly. Now first insert the mouth retractor and mark the resection margins with the electric needle. Dissection with scissors, removing the mucosal changes in the area of the tumorous changes. Removal of the mucosa and the underlying submucosal tissue up to the former tonsil lobe or base of the tongue. All preparation steps under careful hemostasis using bipolar coagulation. The preparation is now marked with sutures. It extends from the right glossotonsillar groove over the alveolar ridge to the anterior third of the right edge of the tongue, passing over to the floor of the mouth. This is followed by thread marking in the anterior (long/long) and lateral (short/short) directions. Representative edge samples are then taken in the area of the anterior edge of the tongue as well as halfway along the area of the floor of the mouth transition and the back of the tongue medially and finally a resection in the area of the cranial tonsil lobe. Then renewed careful inspection and hemostasis using bipolar coagulation. Insertion of hydrogen and Ringer swabs. Meticulous hemostasis. Finally, absolutely dry wound conditions. End of the procedure at this point without any indication of complications.

161/InvasionFront_CD3_block18_x1_y12_patient161_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3248.3,
+    "Centroid Y µm": 34281.8,
+    "Num Detections": 18277,
+    "Num Negative": 18013,
+    "Num Positive": 264,
+    "Positive %": 1.444,
+    "Num Positive per mm^2": 122.23
+  }
+}

161/InvasionFront_CD3_block18_x2_y12_patient161_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 5921.9,
+    "Centroid Y µm": 34431.8,
+    "Num Detections": 22764,
+    "Num Negative": 22658,
+    "Num Positive": 106,
+    "Positive %": 0.4656,
+    "Num Positive per mm^2": 45.63
+  }
+}

161/InvasionFront_CD8_block18_x1_y12_patient161_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4145.1,
+    "Centroid Y µm": 36933.0,
+    "Num Detections": 10937,
+    "Num Negative": 10817,
+    "Num Positive": 120,
+    "Positive %": 1.097,
+    "Num Positive per mm^2": 70.8
+  }
+}

161/InvasionFront_CD8_block18_x2_y12_patient161_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6921.3,
+    "Centroid Y µm": 37055.4,
+    "Num Detections": 17637,
+    "Num Negative": 17585,
+    "Num Positive": 52,
+    "Positive %": 0.2948,
+    "Num Positive per mm^2": 25.3
+  }
+}

161/TumorCenter_CD3_block18_x1_y12_patient161_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3408.4,
+    "Centroid Y µm": 28802.8,
+    "Num Detections": 20127,
+    "Num Negative": 20105,
+    "Num Positive": 22,
+    "Positive %": 0.1093,
+    "Num Positive per mm^2": 10.82
+  }
+}

161/TumorCenter_CD3_block18_x2_y12_patient161_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 5836.3,
+    "Centroid Y µm": 28816.6,
+    "Num Detections": 8856,
+    "Num Negative": 8665,
+    "Num Positive": 191,
+    "Positive %": 2.157,
+    "Num Positive per mm^2": 119.02
+  }
+}

161/TumorCenter_CD8_block18_x1_y12_patient161_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3398.2,
+    "Centroid Y µm": 29859.2,
+    "Num Detections": 16428,
+    "Num Negative": 16397,
+    "Num Positive": 31,
+    "Positive %": 0.1887,
+    "Num Positive per mm^2": 15.03
+  }
+}

161/TumorCenter_CD8_block18_x2_y12_patient161_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 5871.9,
+    "Centroid Y µm": 29884.2,
+    "Num Detections": 15882,
+    "Num Negative": 15762,
+    "Num Positive": 120,
+    "Positive %": 0.7556,
+    "Num Positive per mm^2": 65.87
+  }
+}

161/history_text.txt

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+The patient has a histologically confirmed G2 squamous cell carcinoma, which is growing transglottically and infiltrating on both sides, hence the indication for surgical treatment.

161/icd_codes.txt

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+Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B]

161/ops_codes.txt

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+Einfache Laryngektomie mit Rekonstruktion mit lokaler Schleimhaut[5-303.01 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 B] Myotomie M. constrictor pharyngis mit Pharyngotomie[5-299.01 ] Einlegen einer Stimmprothese[5-319.9 ] Anlage ösophagotracheale Fistel[5-429.0 ]

161/patient_clinical_data.json

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+{
+  "year_of_initial_diagnosis": 2017,
+  "age_at_initial_diagnosis": 52,
+  "sex": "male",
+  "smoking_status": "smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "deceased",
+  "survival_status_with_cause": "deceased not tumor specific",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 27,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "percutaneous radiotherapy",
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

161/patient_pathological_data.json

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+{
+  "patient_id": "161",
+  "primary_tumor_site": "Larynx",
+  "pT_stage": "pT2",
+  "pN_stage": "pN0",
+  "grading": "G3",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": 0.0,
+  "number_of_resected_lymph_nodes": 45,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "CIS Absent",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "0.6",
+  "histologic_type": "SCC_Conventional-NonKeratinizing",
+  "infiltration_depth_in_mm": 2.5
+}

161/surgery_description.txt

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+Laryngectomy, Bilateral neck dissection, Provox insertion

161/surgery_report.txt

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+First, induction of anesthesia by the anesthesia colleagues. Then direct laryngoscopy with the small bore tube and confirmation of findings and indication by <CLINICIAN_NAME> and insertion of a nasogastric tube. Sterile wiping and draping. Skin incision. Dissection of the subcutaneous tissue and the platysma and formation of a subplatysmal apron flap in the typical manner. First dissection of the prelaryngeal and pretracheal fatty tissue in the sense of a level VI neck dissection, followed by exposure and dissection of the prelaryngeal musculature. Exposure of the thyroid isthmus. Dissection of the thyroid gland and visualization of the anterior wall of the trachea. Identification of the hyoid bone. Skeletonization of the hyoid bone and transection of the inferior constrictor muscle along the thyroid cartilage from both sides. Opening of the trachea against the second tracheal ring and re-intubation. Dissection in the direction of the vallecula up to the mucosal level. Opening of the vallecula and exposure of the epiglottis. Disluxation of the epiglottis. Incision along the lateral edges of the epiglottis and along the aryepiglottic folds on both sides. Strict care is taken to maximally preserve the mucosa of the piriform sinus on both sides. The incision is made in the postcricoid area and the mucosa of the hypopharynx is pushed away from the laryngeal skeleton and further dissection between the oesophagus and the posterior wall of the trachea. The larynx is then completely removed. This reveals a large macroscopic safety margin. A frozen section of the postcricoid region and tracheal separation border is sent for frozen section and later assessed as free of carcinoma. Then neck dissection on the right side. Identification of the anterior border of the sternocleidomastoid muscle. Dissection along the jugular vein in a cranial direction. In the cranial section, identification of the accessorius nerve and sparing of the accessorius nerve. The hypoglossal nerve is also identified and spared here. Level II b is then removed. Slide the preparation below the accessorius nerve. Further placement of the preparation caudally with protection of the cervical plexus branches. Modified functional neck dissection Level II to IV is performed, followed by neck dissection on the left side. Here also dissection along the anterior border of the sternocleidomastoid muscle. Exposure and sparing of the accessorius nerve. Exposure of the posterior venter of the digaster muscle and exposure of the internal jugular vein as well as the vagus nerve and the common carotid artery. Dissection along the cervical vascular sheath from caudal to cranial. Successive removal of the posterior and anterior neck preparation while protecting the above-mentioned structures and the plexus branches. A tracheoesophageal fistula is then created and a Provox prosthesis size 10 is inserted approx. 1 cm caudal to the upper tracheal margin. Subsequent palpation of the esophageal entrance. This revealed a relatively wide esophageal entrance. A myotomy was performed on the left side to prevent subsequent narrowing. Adaptation of the tracheal free edge with the stoma and fixation with Ethibond suture. Irrigation of the wound area with hydrogen and Ringer. Hemostasis. Subcutaneous and skin suturing and completion of the procedure without complications. Note: Nasogastric tube until the 10th postoperative day, then perform an X-ray gruel swallow, if this is inconspicuous, then diet build-up. Continue antibiotics for a total of 1 week.

162/InvasionFront_CD3_block1_x1_y4_patient162_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4422.7,
+    "Centroid Y µm": 11568.9,
+    "Num Detections": 19790,
+    "Num Negative": 19169,
+    "Num Positive": 621,
+    "Positive %": 3.138,
+    "Num Positive per mm^2": 286.16
+  }
+}

162/InvasionFront_CD3_block1_x2_y4_patient162_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6921.3,
+    "Centroid Y µm": 11518.9,
+    "Num Detections": 14458,
+    "Num Negative": 14200,
+    "Num Positive": 258,
+    "Positive %": 1.784,
+    "Num Positive per mm^2": 125.23
+  }
+}

162/InvasionFront_CD8_block1_x1_y4_patient162_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 4472.6,
+    "Centroid Y µm": 10119.6,
+    "Num Detections": 17719,
+    "Num Negative": 17207,
+    "Num Positive": 512,
+    "Positive %": 2.89,
+    "Num Positive per mm^2": 256.96
+  }
+}

162/InvasionFront_CD8_block1_x2_y4_patient162_1.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6971.3,
+    "Centroid Y µm": 10219.6,
+    "Num Detections": 11321,
+    "Num Negative": 11200,
+    "Num Positive": 121,
+    "Positive %": 1.069,
+    "Num Positive per mm^2": 74.39
+  }
+}

162/TumorCenter_CD3_block1_x1_y6_patient162_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 3623.1,
+    "Centroid Y µm": 15441.8,
+    "Num Detections": 18042,
+    "Num Negative": 17078,
+    "Num Positive": 964,
+    "Positive %": 5.343,
+    "Num Positive per mm^2": 400.26
+  }
+}

162/TumorCenter_CD3_block1_x2_y6_patient162_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6071.8,
+    "Centroid Y µm": 15366.9,
+    "Num Detections": 16567,
+    "Num Negative": 13149,
+    "Num Positive": 3418,
+    "Positive %": 20.63,
+    "Num Positive per mm^2": 1425.7
+  }
+}

162/TumorCenter_CD8_block1_x1_y4_patient162_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 6221.7,
+    "Centroid Y µm": 18740.1,
+    "Num Detections": 18216,
+    "Num Negative": 16677,
+    "Num Positive": 1539,
+    "Positive %": 8.449,
+    "Num Positive per mm^2": 720.4
+  }
+}

162/TumorCenter_CD8_block1_x2_y4_patient162_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 8820.3,
+    "Centroid Y µm": 18790.1,
+    "Num Detections": 17504,
+    "Num Negative": 16785,
+    "Num Positive": 719,
+    "Positive %": 4.108,
+    "Num Positive per mm^2": 333.73
+  }
+}

162/history_text.txt

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+Post-panendoscopy from <2016> with ablation of leukoplakia in the area of the right alveolar ridge and right anterior palatal arch. Histology revealed a carcinoma in situ on the right alveolar ridge and a G3 differentiated squamous cell carcinoma and carcinoma in situ on the right anterior palatal arch. Post-resection with intraoperative frozen section diagnostics was discussed at the interdisciplinary tumor conference.

162/icd_codes.txt

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+Bösartige Neubildung des weichen Gaumens[C05.1 R]

162/ops_codes.txt

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+Gaumenbogenkarzinom-Resektion[5-272.1 ] Biopsie am Gaumen ohne Inzision[1-420.2 ]

162/patient_clinical_data.json

@@ -0,0 +1,18 @@
+{
+  "year_of_initial_diagnosis": 2016,
+  "age_at_initial_diagnosis": 65,
+  "sex": "male",
+  "smoking_status": "smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 0,
+  "adjuvant_treatment_intent": null,
+  "adjuvant_radiotherapy": "no",
+  "adjuvant_radiotherapy_modality": null,
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

162/patient_pathological_data.json

@@ -0,0 +1,20 @@
+{
+  "patient_id": "162",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT1",
+  "pN_stage": "NX",
+  "grading": "G3",
+  "hpv_association_p16": "negative",
+  "number_of_positive_lymph_nodes": NaN,
+  "number_of_resected_lymph_nodes": 0,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "yes",
+  "closest_resection_margin_in_cm": "<0.1",
+  "histologic_type": "SCC_Conventional-NonKeratinizing",
+  "infiltration_depth_in_mm": 4.0
+}

162/surgery_description.txt

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+Excisional biopsy

162/surgery_report.txt

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+Team time out and induction of anesthesia by the anesthesia colleagues with intubation. Dental status determined. Insertion of the Mc Ivor oral spatula and exposure of the right oropharynx: A slightly rough, spherical protrusion with smooth mucosa, approx. 0.8 cm in diameter, can be seen in the area of the former ablation on the anterior right palatal arch. Laterocaudally, the alveolar ridge is somewhat exposed after previous surgery. In addition, there is a leukoplakia on the right posterior palatal arch, which was not present 4 weeks ago, measuring approx. 3 x 6 mm longitudinally oval. No other new mucosal abnormalities in the rest of the oropharynx. Infiltration of the anterior and posterior right palatal arch with local anesthesia, Ultracaine 2% with the addition of Suprarenin. Now excision biopsy of the leukoplakia on the right posterior palatal arch with a 5 mm safety margin using a scalpel and pointed scissors. Suture marking still in the surgical site at 12 o'clock (cranial) and at 9 o'clock (lateral). The frozen section examination according to the telephone announcement by the pathologists shows a 2 cm large carcinoma in situ in the resectate, whereby a marginal formation in the frozen section at 12 o'clock cannot be ruled out, thus recommendation for subsequent resection, which takes place later. First, the already planned resection on the anterior palatal arch on the right: with a safety margin of approx. 5 mm, the raised, rough mass is cut around with the scalpel and pointed scissors on a smooth mucosal surface. Here too, suture marking in the surgical site at 6 o'clock (caudal) and 9 o'clock (lateral). The required size of the resection results in a defect in the anterior palatal arch, which is later adapted. According to the pathology department, the frozen section examination shows an invasive carcinoma of 0.2 cm originating from the CIS, which forms the cranial margin and also a moderate degree of dysplasia laterally, whereby it cannot be clearly distinguished from the CIS in the frozen section. Therefore recommendation for resection here as well. Preoperative demonstration to the previous surgeon <CLINICIAN_NAME>. Now case discussion with <CLINICIAN_NAME>, also based on the tumor conference decision, see file. Now indication for subsequent resection at the above-mentioned sites in accordance with the pathological recommendation, this time for definitive histology as well as an additional biopsy on the left anterior palatal arch in macroscopically unremarkable conditions to clarify whether a carcinoma in situ is also present here in the current case of field carcinomatization. Then discussion at the tumor conference and no PEG placement today. Now follow-up resections: Posterior palatal arch on the right: cranial resection of an approx. 5 mm wide strip of mucosa using a scalpel and pointed scissors. This is marked with sutures in the operating theater, both medially and cranially. Send in for definitive histology. Right anterior palatal arch resection: resection of a 5 mm wide strip of mucosa using a scalpel and pointed scissors, covering the entire area from medial to cranial to laterocaudal, triple suture markings. Sketch/photo with all markings see file. Finally, the right anterior palatal arch is adapted into the wound bed with Vicryl 4-0. No bleeding. In addition, biopsy of the left anterior palatal arch. No bleeding. Finally, insertion of a nasogastric feeding tube due to the extensive resection defect in the right oropharynx. Position control under direct vision and auscultatory with air insufflation. The procedure was completed without complications. Conclusion: Post-resection of the anterior right palatal arch for invasive squamous cell carcinoma originating from a carcinoma in situ and excisional biopsy of the posterior right palatal arch for carcinoma in situ; frozen section control. An additional resection of both sites was performed and will be followed by definitive histology. In case of suspected field carcinoma, biopsy of the left anterior palatal arch in a pale mucosal area. Procedure: Discussion in the tumor conference of the definitive histologies of the frozen section and the post-resectates. A PEG was deliberately avoided (see above). A PEG should only be inserted if radiochemotherapy is definitely indicated. Nasogastric tube in the right oropharynx for 3-5 days depending on the findings.

163/InvasionFront_CD3_block17_x3_y12_patient163_0.json

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+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10419.5,
+    "Centroid Y µm": 35056.4,
+    "Num Detections": 16805,
+    "Num Negative": 16485,
+    "Num Positive": 320,
+    "Positive %": 1.904,
+    "Num Positive per mm^2": 145.36
+  }
+}

163/InvasionFront_CD3_block17_x4_y12_patient163_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 12968.1,
+    "Centroid Y µm": 35181.4,
+    "Num Detections": 19494,
+    "Num Negative": 18844,
+    "Num Positive": 650,
+    "Positive %": 3.334,
+    "Num Positive per mm^2": 291.3
+  }
+}

163/InvasionFront_CD8_block17_x3_y12_patient163_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 11119.1,
+    "Centroid Y µm": 29734.3,
+    "Num Detections": 17188,
+    "Num Negative": 17045,
+    "Num Positive": 143,
+    "Positive %": 0.832,
+    "Num Positive per mm^2": 63.65
+  }
+}

163/InvasionFront_CD8_block17_x4_y12_patient163_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13617.8,
+    "Centroid Y µm": 29684.3,
+    "Num Detections": 17843,
+    "Num Negative": 17510,
+    "Num Positive": 333,
+    "Positive %": 1.866,
+    "Num Positive per mm^2": 141.92
+  }
+}

163/TumorCenter_CD3_block17_x3_y12_patient163_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10644.4,
+    "Centroid Y µm": 29634.3,
+    "Num Detections": 16633,
+    "Num Negative": 16041,
+    "Num Positive": 592,
+    "Positive %": 3.559,
+    "Num Positive per mm^2": 282.46
+  }
+}

163/TumorCenter_CD3_block17_x4_y12_patient163_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 12993.1,
+    "Centroid Y µm": 29609.3,
+    "Num Detections": 14937,
+    "Num Negative": 14737,
+    "Num Positive": 200,
+    "Positive %": 1.339,
+    "Num Positive per mm^2": 110.54
+  }
+}