Add files using upload-large-folder tool

375/icd_codes.txt

@@ -0,0 +1 @@
+Bösartige Neubildung Larynx mehrere Teilbereiche überlappend[C32.8 B]

375/surgery_description.txt

@@ -0,0 +1 @@
+Laryngectomy, Bilateral neck dissection, Provox insertion, Pharyngoscopy, Laryngoscopy

375/surgery_report.txt

@@ -0,0 +1 @@
+First, pharyngoscopy and laryngoscopy again, showing the exophytic tumor, which runs from the interary area centrally over both vocal folds, the anterior commissure to the arytenoid region on the left. Overall, not a large voluminous tumor, but rather a very extensive flat finding, which makes a larynx-preserving procedure inappropriate. Cartilage infiltration in the area of the anterior commissure, at least from the inside, cannot be ruled out. Therefore, repositioning for surgical therapy. Skin disinfection. Sterile draping. Injection of a total of 10 ml Ultracaine 1% with adrenaline in the area of the planned incision. Then elevation of the apron flap and neck dissection on both sides. Start with the neck dissection on the left side: dissection of the sternocleidomastoid muscle, exposure and protection of the XI nerve. Dissection of the cranial border with exposure of the lower edge of the gl. submandibularis and the digaster muscle. Locate and dissect the omohyoid muscle. No macroscopically suspicious nodes. On this side, regions Ib-V are completely removed while preserving all non-lymphatic structures. Transition to neck dissection on the right side, here the procedure is carried out in the same way. Final demonstration of findings on <CLINICIAN_NAME>." Subsequent laryngectomy: Dissection of the suprahyoid muscles from the hyoid bone, which is completely skeletonized. Exposure of the superior chorda on both sides and release of this on both sides. Exposure of the thyroid gland on both sides, transection of the isthmus. Thyroid gland is dissected caudo-laterally on both sides. Infrahyoid muscles are detached from the hyoid bone and beaten downwards. Constrictor muscle, pharynx with pharyngeal tube is dissected away from the pharyngeal skeleton as far as possible. Tracheotomy is then performed. Re-intubation. Then enter the larynx in the area of the epiglottis. The area of the lingual epiglottis mucosa is spared as far as possible. Then successive release of the larynx with maximum preservation of the pharyngeal mucosa. Separate the laryngeal skeleton from the pharyngeal tube up to the beginning of the trachea. Here the larynx is set down in a typical manner. In the case of subglottic growth, creation of the tracheostoma in the typical manner. Larynx is sent in for frozen section, here in frozen section cranial and caudal in the area of the mucosal settling points or trachea and epiglottis in sano. Subsequently, myotomy on the left side in the typical manner. The muscles of the pharyngeal tube are severed. Then separation of the sternocleidomastoid muscle in the area of the medial insertions on both sides. Then insertion of a 10 mm Provox prosthesis in the typical manner. This is positioned correctly. Then closure of the pharynx in a single layer using single button sutures. Further inverted suture in the second layer. Suturing of the pharyngeal tube or constrictor pharyngis and suprahyoidal muscles cranially, also using single Vicryl 3-0 button sutures. Then irrigation and careful hemostasis. Wound closure in layers with insertion of Redon drainage on both sides and epithelialization of the tracheostoma. Subsequent completion of the procedure without complications. Overall cT3-4 carcinoma endolaryngeal. Due to questionable cartilage infiltration to the front and the overall extension, laryngectomy was performed with neck dissection on both sides. Please feed via the inserted nasogastric tube for 8-10 days, then after swallowing gruel, if necessary, build up the diet. Please continue antibiotics, which were started with Unacid, for one week. After receiving the final histology, please attend the interdisciplinary tumor conference for further treatment planning.

376/InvasionFront_CD3_block5_x5_y8_patient376_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16441.3,
+    "Centroid Y µm": 20414.2,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

376/InvasionFront_CD3_block5_x6_y8_patient376_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 18865.0,
+    "Centroid Y µm": 20389.2,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

376/InvasionFront_CD8_block5_x5_y6_patient376_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16241.4,
+    "Centroid Y µm": 15366.9,
+    "Num Detections": 21036,
+    "Num Negative": 20691,
+    "Num Positive": 345,
+    "Positive %": 1.64,
+    "Num Positive per mm^2": 138.12
+  }
+}

376/InvasionFront_CD8_block5_x6_y6_patient376_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 18840.0,
+    "Centroid Y µm": 15466.8,
+    "Num Detections": 23202,
+    "Num Negative": 22987,
+    "Num Positive": 215,
+    "Positive %": 0.9266,
+    "Num Positive per mm^2": 82.24
+  }
+}

376/TumorCenter_CD3_block5_x5_y6_patient376_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 17066.0,
+    "Centroid Y µm": 15441.8,
+    "Num Detections": 23360,
+    "Num Negative": 22635,
+    "Num Positive": 725,
+    "Positive %": 3.104,
+    "Num Positive per mm^2": 273.84
+  }
+}

376/TumorCenter_CD3_block5_x6_y6_patient376_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 19614.6,
+    "Centroid Y µm": 15716.7,
+    "Num Detections": 22701,
+    "Num Negative": 21528,
+    "Num Positive": 1173,
+    "Positive %": 5.167,
+    "Num Positive per mm^2": 430.36
+  }
+}

376/TumorCenter_CD8_block5_x5_y6_patient376_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16141.5,
+    "Centroid Y µm": 15192.0,
+    "Num Detections": 22861,
+    "Num Negative": 22708,
+    "Num Positive": 153,
+    "Positive %": 0.6693,
+    "Num Positive per mm^2": 57.77
+  }
+}

376/TumorCenter_CD8_block5_x6_y6_patient376_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 18715.1,
+    "Centroid Y µm": 15241.9,
+    "Num Detections": 22223,
+    "Num Negative": 21866,
+    "Num Positive": 357,
+    "Positive %": 1.606,
+    "Num Positive per mm^2": 131.48
+  }
+}

376/history_text.txt

@@ -0,0 +1 @@
+The patient has been suffering from difficulty swallowing in the right-sided tongue area for 1 year. The panendoscopy revealed a squamous cell carcinoma G1.

376/icd_codes.txt

@@ -0,0 +1 @@
+Karzinom Oropharynx mehrere Teilbereiche überlappend[C10.8 R]

376/ops_codes.txt

@@ -0,0 +1 @@
+Direkte diagnostische Pharyngoskopie[1-611.0 ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroduodenoskopie bei normalem Situs[1-632.0 ] Perkutan-endoskopische Gastrostomie durch Fadendurchzugsmethode[5-431.20 ] Gaumentumorexzision[5-272.0 ] Radikale zervikale Lymphadenektomie [Neck dissection] selektiv [funktionell] 3 Regionen[5-403.02 B] Transplantat[5-295.14 ] Deckung mit freiem Radialis-Lappen Kopf und Hals[5-858.70 R] Entnahme freier Radialis-Lappen[5-858.23 L] Spalthaut Entnahmestelle Oberschenkel und Knie[5-901.0e R] Spalthautdeckung großflächig Empfängerstelle Unterarm[5-902.48 L] Permanente Tracheotomie mit mukokutaner Anastomose[5-312.2 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Wechsel Implantat Gefäße Kopf und Hals extrakraniell[5-394.3 ] Mikrochirurgische Technik (Zusatzkode)[5-984 ] Entfernung Glandula submandibularis ohne intraoperatives Monitoring des Ramus marginalis N. facialis[5-262.40 R]

376/patient_clinical_data.json

@@ -0,0 +1,18 @@
+{
+  "year_of_initial_diagnosis": 2017,
+  "age_at_initial_diagnosis": 72,
+  "sex": "male",
+  "smoking_status": "smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 10,
+  "adjuvant_treatment_intent": "curative",
+  "adjuvant_radiotherapy": "yes",
+  "adjuvant_radiotherapy_modality": "brachytherapy",
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

376/patient_pathological_data.json

@@ -0,0 +1,20 @@
+{
+  "patient_id": "376",
+  "primary_tumor_site": "Oropharynx",
+  "pT_stage": "pT2",
+  "pN_stage": "pN0",
+  "grading": "G3",
+  "hpv_association_p16": "negative",
+  "number_of_positive_lymph_nodes": 0.0,
+  "number_of_resected_lymph_nodes": 47,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "no",
+  "closest_resection_margin_in_cm": "0.5",
+  "histologic_type": "SCC_Conventional-NonKeratinizing",
+  "infiltration_depth_in_mm": 5.0
+}

376/surgery_description.txt

@@ -0,0 +1 @@
+Tumor resection, Bilateral neck dissection, Flap coverage, Free flap (Radial), Tracheotomy, PEG placement

376/surgery_report.txt

@@ -0,0 +1 @@
+Induction of anesthesia and intubation by the anesthesia colleagues. Then first sterile washing and draping of the neck area and performance of the tracheotomy by <CLINICIAN_NAME> and <CLINICIAN_NAME>, here skin incision below the cricoid cartilage, preparation of the prelaryngeal musculature, splitting of the musculature at the linea alba. Exposure of the thyroid isthmus, separation of the thyroid isthmus. Exposure of the anterior wall of the trachea. Insertion between the 2nd and 3rd tracheal cartilage. Creation of a visor tracheotomy. Then repositioning and remaining washing and draping. Neck dissection on the right, PEG placement and tracheostomy by <CLINICIAN_NAME>. Start of PEG insertion: insertion with the flexible oesophagogastroscope and easy pre-scanning with air insufflation into the stomach. Positive diaphanoscopy and problem-free placement of a PEG using the thread pull-through method without any problems. Dressing application. Transition to tracheotomy: positioning of the patient and marking of the incision and skin incision, subcutaneous preparation, pushing apart the infrahyoid muscles and exposing the thyroid isthmus. Undermining of the same, bipolar coagulation and separation of the isthmus from the trachea. Locate the space between the 2nd and 3rd tracheal cartilage and carefully enter. Creation of a visor tracheotomy. Transfer to a laryngectomy tube. Repositioning for tumor removal and neck dissection, primarily on the right side. Injection of 10 ml local anesthetic with adrenaline along the planned incision and along the right side of the neck. Skin incision, exposure of the sternocleidomastoid muscle, exposure of its profound surface, exposure and sparing of the accessorius nerve. Exposure of the posterior belly of the digastric muscle. Exposure and protection of the hypoglossal nerve. Exposure of the cervical vascular sheath. Visualization of the vagus nerve. Dissection of the lateral neck preparation, transection in the cranial area. Removal of the submandibular gland together with the attached lymph nodes. Dissection and gentle removal of the facial artery as a connecting vessel for subsequent flap preparation. Separation of the facial vein. Dissection inferiorly and exposure of the omohyoid muscle. Further dissection in a superior direction and lifting of the medial neck preparation. Hemostasis and leaving the site open for later flap preparation. Simultaneously, the tumor is released enorally by <CLINICIAN_NAME> and counter-operated on transcervically. This is followed by transoral, transcervical tumor resection: first insertion of the Mc Ivor blade and re-inspection of the tumor. The tumor is mainly located in the middle to lower part of the tonsillar lobe, passing just over the base of the tongue and growing slightly towards the glosso-alveolar groove or alveolar ridge, but at a clear distance. The tumor is now removed macroscopically with a safety margin of at least 1.5 to even 2 cm on all sides. The anterior palatal arch, the tonsil and parts of the posterior palatal arch are removed. During removal, the bone on the alveolar ridge is also exposed at the back by pushing away the periosteum here. Caudal resection of parts of the base of the tongue is carried out here at a clear distance. The beginning of the posterior wall of the hypopharynx and posterior wall of the oropharynx is also resected. Due to the growth at one point in depth in the direction of the submandibular gland, the tumor is then resected from the transcervical side as part of the neck dissection. After cutting the digastric muscle, the submandibular gland is mobilized. The hypoglossal nerve is exposed and spared for this purpose. The lingual nerve was already severed during the resection from the enoral side, as it runs too close to the tumor or was infiltrated by the tumor. Glandula submandibularis is now pushed into the oral cavity en bloc with the tumor and attached soft tissue. It can be seen that the tumor was resected macroscopically with a wide safety margin on all sides. Nevertheless, another marginal sample was taken at the alveolar ridge extending to the glossotonsillar groove. Tumor is marked with a thread and sent for frozen section together with the marginal sample. The frozen section shows carcinoma in situ on all sides, partly with transition to microcarcinoma, only in the area of the posterior palatal arch there is no carcinoma in situ. A large strip of mucosa is now removed from the alveolar ridge, whereby the mucosa is removed down to the alveoli. In addition, a large resectate is removed from the caudal pharyngeal wall, as well as a wide resectate from the pharyngeal entrance, vallecula area to the base of the tongue. All resected specimens are sent for re-examination as frozen sections, with the sutures placed away from the tumor. Carcinoma in situ again in almost all specimens. After consultation with the pathologists, this appears to be a field carcinoma. Therefore, only the specimen in the caudal pharyngeal region appears to be free of tumor and no carcinoma in situ is detectable. This is followed by a final marginal sample from the vallecula/base of tongue area, where the sutures are again placed away from the tumor. However, this is no longer a frozen section examination but a final examination. It is no longer possible to take a mucosal sample from the alveolar ridge, as the resection has already reached the beginning of the alveolus. The mucosa is healthy towards the floor of the mouth. R1 affected areas are therefore the dorsal alveolar ridge and the base of the tongue/valley area. Overall tendency towards field carcinomatization after consultation with the pathologist. Neck dissection on the left side (<CLINICIAN_NAME>): Injection of 10 ml ultracaine solution, making a skin incision from the mastoid at the anterior margin of the sternocleidomastoid caudally with a slight swing laterally. Expose the platysma. Create a platysma flap anteriorly, expose the sternocleidomastoid. Mobilization of the muscle, sharp dissection in depth up to the plexus branches. The cranial accessorius nerve is exposed. Now follow and mobilize the omohyoid muscle and expose the substructure of the submandibular gland. The gland is now pulled upwards until the digaster muscle is exposed. Exposure of the digaster muscle. Now insert a retractor in the caudal region. Expose the internal jugular vein. Dissect the vein from caudal to cranial, follow the outlets anteriorly, coagulate a small outlet. Now mobilize the neck preparation in level II in the anterior triangle, exposing the hypoglossal nerve and the facial artery. There is bleeding from a small branch of the facial artery, which is ligated. Separation of the anterior triangle up to the omohyoid muscle. Now evacuate level IIa. Pass the neck preparation under the accessorius and dissect caudally via levels III and IV, sparing the plexus branches of the vagus nerve and the internal carotid artery, which is exposed. Finally, check for bloodlessness, which is present. Insertion of a Redon drainage and two-layer wound closure. At the same time, the radial artery graft is lifted from the arm. The extent of the visible tumor was measured to be 8 x 6 cm. A buffer with a final graft size of 12 x 8 cm is also lifted from the forearm. For this purpose, the graft is marked, the graft is cut around and the skin is incised in the proximal forearm area. Exposure of the vein star. The second concomitant vein of the flap stalk has no contact with the superficial system or the venous confluence. The first concomitant vein opens into the venous confluence. Then lift the radialis graft, exposing the brachioradialis muscle of the superficial ramus of the radial nerve, the radial artery and lift the graft from the tendon bed and dissect the pedicle in the usual manner. Deposition of the graft in the usual manner and closure of the forearm with split skin from the thigh. The frozen section still showed carcinoma in situ with microinvasion in the marginal samples, therefore <CLINICIAN_NAME> resected 3 more times and the 2nd resection also showed carcinoma in situ with microinvasion, the third resection was taken in the area of the vallecula and sent for final histology. In the end, the resection significantly enlarged the defect so that the graft could only be sutured in under tension and with difficulty. The anastomosis was then performed using the facial artery. The facial artery is altered like a plaque and the endothelium has already detached over a long distance within the vessel. Therefore, 2 suture attempts were necessary to connect the radial artery with the facial artery. Two veins were couplers, one directly from the concomitant vein with an outlet from the internal jugular vein and then two outlets from the venous confluence with two outlets from the facial vein. At the end, insertion of a Redon drainage (Jackson type) and two-layer wound closure and insertion of an 8-gauge tracheostomy tube. Inspection of the oral cavity and the graft. The graft shows a good blood supply (random sample). Prior to the tumor resection, a PEG was inserted using the thread pull-through method without any problems.

377/InvasionFront_CD3_block10_x3_y4_patient377_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13692.7,
+    "Centroid Y µm": 15316.9,
+    "Num Detections": 20807,
+    "Num Negative": 20129,
+    "Num Positive": 678,
+    "Positive %": 3.259,
+    "Num Positive per mm^2": 258.09
+  }
+}

377/InvasionFront_CD3_block10_x4_y4_patient377_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16341.3,
+    "Centroid Y µm": 15566.8,
+    "Num Detections": 23207,
+    "Num Negative": 22690,
+    "Num Positive": 517,
+    "Positive %": 2.228,
+    "Num Positive per mm^2": 194.4
+  }
+}

377/InvasionFront_CD8_block10_x3_y4_patient377_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 12693.3,
+    "Centroid Y µm": 15541.8,
+    "Num Detections": 22329,
+    "Num Negative": 22038,
+    "Num Positive": 291,
+    "Positive %": 1.303,
+    "Num Positive per mm^2": 109.94
+  }
+}

377/InvasionFront_CD8_block10_x4_y4_patient377_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 15366.9,
+    "Centroid Y µm": 15666.7,
+    "Num Detections": 24686,
+    "Num Negative": 24345,
+    "Num Positive": 341,
+    "Positive %": 1.381,
+    "Num Positive per mm^2": 126.21
+  }
+}

377/TumorCenter_CD3_block10_x3_y4_patient377_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13617.8,
+    "Centroid Y µm": 9844.8,
+    "Num Detections": 3405,
+    "Num Negative": 2974,
+    "Num Positive": 431,
+    "Positive %": 12.66,
+    "Num Positive per mm^2": 977.06
+  }
+}

377/TumorCenter_CD3_block10_x4_y4_patient377_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 16216.4,
+    "Centroid Y µm": 9794.8,
+    "Num Detections": 4677,
+    "Num Negative": 4383,
+    "Num Positive": 294,
+    "Positive %": 6.286,
+    "Num Positive per mm^2": 487.14
+  }
+}

377/TumorCenter_CD8_block10_x3_y4_patient377_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10869.2,
+    "Centroid Y µm": 10544.4,
+    "Num Detections": 21049,
+    "Num Negative": 19876,
+    "Num Positive": 1173,
+    "Positive %": 5.573,
+    "Num Positive per mm^2": 519.01
+  }
+}

377/TumorCenter_CD8_block10_x4_y4_patient377_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13442.9,
+    "Centroid Y µm": 10494.4,
+    "Num Detections": 18780,
+    "Num Negative": 18142,
+    "Num Positive": 638,
+    "Positive %": 3.397,
+    "Num Positive per mm^2": 296.3
+  }
+}

377/history_text.txt

@@ -0,0 +1 @@
+In the patient, a differentiated squamous cell carcinoma in the right hypopharyngeal region had already been histologically confirmed externally.  <2013> the extension was determined. Suspicion of tumor growth towards the cervical vascular sheath. Sonographic and computed tomographic cN0 and cM0 status. In our interdisciplinary tumor conference, primary surgical treatment was recommended; due to the growth, an external approach with flap coverage if necessary was favoured.

377/icd_codes.txt

@@ -0,0 +1 @@
+Bösartige Neubildung: Hypopharynx, nicht näher bezeichnet[C13.9 ]

377/ops_codes.txt

@@ -0,0 +1 @@
+Sonstige diagnostische Pharyngoskopie[1-611.x ] Direkte diagnostische Laryngoskopie[1-610.0 ] Diagnostische Ösophagogastroskopie[1-631 ] Sonstige partielle Resektion des Pharynx [Pharynxteilresektion] ohne Rekonstruktion[5-295.x0 ] Transorale partielle Resektion des Pharynx ohne Rekonstruktion[5-295.00 ] Radikale zervikale Lymphadenektomie [Neck dissection] radikal modifiziert 5 Regionen[5-403.21 B] Anlage perkutan-endoskopische Gastrostomie [PEG][5-431.2 ]

377/patient_clinical_data.json

@@ -0,0 +1,18 @@
+{
+  "year_of_initial_diagnosis": 2013,
+  "age_at_initial_diagnosis": 64,
+  "sex": "female",
+  "smoking_status": "smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "deceased",
+  "survival_status_with_cause": "deceased not tumor specific",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 38,
+  "adjuvant_treatment_intent": null,
+  "adjuvant_radiotherapy": "no",
+  "adjuvant_radiotherapy_modality": null,
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

377/patient_pathological_data.json

@@ -0,0 +1,20 @@
+{
+  "patient_id": "377",
+  "primary_tumor_site": "Hypopharynx",
+  "pT_stage": "pT1",
+  "pN_stage": "pN0",
+  "grading": "G2",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": 0.0,
+  "number_of_resected_lymph_nodes": 23,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "yes",
+  "closest_resection_margin_in_cm": "<0.1",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 6.0
+}

377/surgery_description.txt

@@ -0,0 +1 @@
+Transoral partial laser resection, PEG, Neck dissection

377/surgery_report.txt

@@ -0,0 +1 @@
+First, after induction and intubation by the anesthesia colleagues, re-inspection with the Kleinsasser tube. Here, entry with the Kleinsasser tube under dental protection. Inconspicuous oral cavity and oropharynx. As described above, there is an exophytic mass in the area of the right hypopharynx, mainly located in the area of the posterior wall and just reaching the lateral wall in the current status. Otherwise no laryngeal affection. The tip of the piriform sinus as well as the anterior wall and the medial wall are tumor-free, so that the initial description of the tumor must be qualified if the tumor is palpably displaceable. With good displacement, good possibility for laser resection. Therefore resection after adjustment of the tumor, microscopically controlled with the 5 Watt CO2 laser, with adequate safety distance. Regular tissue conditions on all sides, even at depth. No growth towards the vascular nerve sheath. The tumor can now be resected macroscopically and palpatorily in depth and to the side completely in sano. In the area of the mucosal level and the submucosal area, completely forming marginal specimens follow; these are described in the frozen section diagnostics as completely free of dysplasia and tumor. Therefore a clear R0 situation. Careful hemostasis using monopolar coagulation and, if the wound is finally dry, proceed to neck dissection. Neck dissection. First to the right side. Skin incision made at the front edge of the sternocleidomastoid muscle. Cut through skin and subcutaneous tissue. Dissection of the platysma. Exposure and preservation of the external jugular vein and auricular nerve. Exposure of the sternocleidomastoid muscle, omohyoid muscle. Exposure of the submandibular gland, including the caudal capsule, and exposure of the digastric muscle. Release of the anterior neck preparation while carefully protecting the facial vein, the superior thyroid artery and the cervical artery. In the area of the lateral pharyngeal wall, no evidence of a penetrating defect. Dissection of the internal jugular vein. Clearing of the accessorius triangle while protecting the nerve and clearing of level V while carefully protecting the cervical plexus branches. Final wound irrigation and, if dry and intact, insertion of a 10 Redon drain and careful two-layer wound closure. Then turn to the opposite side. Exactly the same procedure here. The incision is also made on the anterior edge of the sternocleidomastoid muscle. Exposure of the limiting musculature. Expose the submandibular gland, also taking the caudal capsule with it. Evacuation of level II a to V a while sparing the facial vein, the superior thyroid artery, the cervical sinus, the accessorius nerve and the cervical plexus. Followed by wound irrigation. Insertion of a 10-gauge Redon drain and two-layer wound closure. Macroscopic cervical confirmation of cN0 neck status on both sides. Due to the location of the tumor, <CLINICIAN_NAME> indicated the placement of a PEG. For this purpose, insertion with the flexible esophagogastroscope under laryngoscopic control. Easy to see through to the stomach. However, computed tomography reveals a suspected thoracic stomach with a clear cranial displacement. Nevertheless, with excellent diaphanoscopy, puncture of the stomach and subsequent insertion of the PEG tube using the usual suture pull-through method was successful. Finally, the findings region is adjusted. This shows dry and slim conditions. Completely slender endolarynx, so that the procedure is terminated at this point. Conclusion: Intraoperative R0-resected cT1 cN0 hypopharyngeal carcinoma on the right. Postoperatively, please abstain from food for 7 days, then carefully and gradually build up the diet and after receiving the definitive histology, presentation at our interdisciplinary tumor conference to discuss adjuvant therapy.  

378/InvasionFront_CD3_block18_x3_y3_patient378_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 11743.8,
+    "Centroid Y µm": 12093.6,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

378/InvasionFront_CD3_block18_x4_y3_patient378_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 14442.4,
+    "Centroid Y µm": 12243.5,
+    "Num Detections": 0,
+    "Num Negative": 0,
+    "Num Positive": 0,
+    "Positive %": NaN,
+    "Num Positive per mm^2": NaN
+  }
+}

378/InvasionFront_CD8_block18_x3_y3_patient378_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 11608.3,
+    "Centroid Y µm": 15422.9,
+    "Num Detections": 14234,
+    "Num Negative": 13001,
+    "Num Positive": 1233,
+    "Positive %": 8.662,
+    "Num Positive per mm^2": 788.55
+  }
+}

378/InvasionFront_CD8_block18_x4_y3_patient378_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 14008.7,
+    "Centroid Y µm": 15393.3,
+    "Num Detections": 20567,
+    "Num Negative": 18834,
+    "Num Positive": 1733,
+    "Positive %": 8.426,
+    "Num Positive per mm^2": 776.38
+  }
+}

378/TumorCenter_CD3_block18_x3_y3_patient378_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10944.6,
+    "Centroid Y µm": 7341.1,
+    "Num Detections": 16022,
+    "Num Negative": 15533,
+    "Num Positive": 489,
+    "Positive %": 3.052,
+    "Num Positive per mm^2": 213.62
+  }
+}

378/TumorCenter_CD3_block18_x4_y3_patient378_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13426.8,
+    "Centroid Y µm": 7364.3,
+    "Num Detections": 16758,
+    "Num Negative": 16337,
+    "Num Positive": 421,
+    "Positive %": 2.512,
+    "Num Positive per mm^2": 185.02
+  }
+}

378/TumorCenter_CD8_block18_x3_y3_patient378_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10894.2,
+    "Centroid Y µm": 7995.8,
+    "Num Detections": 17445,
+    "Num Negative": 16337,
+    "Num Positive": 1108,
+    "Positive %": 6.351,
+    "Num Positive per mm^2": 470.83
+  }
+}

378/TumorCenter_CD8_block18_x4_y3_patient378_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13392.9,
+    "Centroid Y µm": 8020.8,
+    "Num Detections": 18652,
+    "Num Negative": 17526,
+    "Num Positive": 1126,
+    "Positive %": 6.037,
+    "Num Positive per mm^2": 474.07
+  }
+}

378/history_text.txt

@@ -0,0 +1 @@
+Patient with histologically confirmed cT2 cN0 G2 squamous cell carcinoma of the right glottis and subglottis on the right side with clear involvement of the anterior commissure and slight transition into the left glottis. Thus indication for the above-mentioned measures.

378/icd_codes.txt

@@ -0,0 +1 @@
+cT1a glott. Larynx-Ca[C32.0 ]

378/ops_codes.txt

@@ -0,0 +1 @@
+Partielle Laryngektomie Teilresektion frontolateral [Leroux-Robert][5-302.7 ] Direkte diagnostische Laryngoskopie[1-610.0 ]

378/patient_clinical_data.json

@@ -0,0 +1,18 @@
+{
+  "year_of_initial_diagnosis": 2018,
+  "age_at_initial_diagnosis": 72,
+  "sex": "male",
+  "smoking_status": "non-smoker",
+  "primarily_metastasis": "no",
+  "survival_status": "living",
+  "survival_status_with_cause": "living",
+  "first_treatment_intent": "curative",
+  "first_treatment_modality": "local surgery",
+  "days_to_first_treatment": 15,
+  "adjuvant_treatment_intent": null,
+  "adjuvant_radiotherapy": "no",
+  "adjuvant_radiotherapy_modality": null,
+  "adjuvant_systemic_therapy": "no",
+  "adjuvant_systemic_therapy_modality": null,
+  "adjuvant_radiochemotherapy": "no"
+}

378/patient_pathological_data.json

@@ -0,0 +1,20 @@
+{
+  "patient_id": "378",
+  "primary_tumor_site": "Larynx",
+  "pT_stage": "pT1",
+  "pN_stage": "NX",
+  "grading": "G2",
+  "hpv_association_p16": "not_tested",
+  "number_of_positive_lymph_nodes": NaN,
+  "number_of_resected_lymph_nodes": 0,
+  "perinodal_invasion": null,
+  "lymphovascular_invasion_L": "no",
+  "vascular_invasion_V": "no",
+  "perineural_invasion_Pn": "no",
+  "resection_status": "R0",
+  "resection_status_carcinoma_in_situ": "Ris0",
+  "carcinoma_in_situ": "yes",
+  "closest_resection_margin_in_cm": "0.1",
+  "histologic_type": "SCC_Conventional-Keratinizing",
+  "infiltration_depth_in_mm": 2.0
+}

378/surgery_description.txt

@@ -0,0 +1 @@
+Partial resection, frontolateral (Leroux-Robert)

378/surgery_report.txt

@@ -0,0 +1 @@
+First induction of anesthesia. Transoral endotracheal intubation by the anesthetist. Positioning of the patient by the surgeon. Laryngoscopy and microlaryngoscopy are performed. This shows an uneven mucosal change, clearly growing in depth, which infiltrates the right vocal fold from posterior to anterior (and caudally in its subglottic slope) and then passes over the anterior commissure to the left side. Due to the clear deep infiltration of the anterior commissure and after demonstration of the findings on <CLINICIAN_NAME>, the decision was made to perform a transcervical partial laryngectomy. Removal of the Kleinsasser C-tube and subsequent skin spray disinfection. Application of local anesthesia in a skin fold at the level of the thyroid cartilage. Ablate the skin and cover sterilely. Creation of a skin incision approx. 5 cm long. Cut through the subcutaneous tissue and the platysma. Creation of a subplatysmal flap up to the thyroid incisura cranially and below the cricoid cartilage caudally. Exposure and ligation of the anterior jugular vein. Exposure and transection of the prelaryngeal muscles in the midline. Exposure of the thyroid cartilage, the ligamentum conicum and the cricoid cartilage. Scalpel incision of the perichondrium of the thyroid cartilage. Formation of two laterally pedicled perichondrium lobes. Cutting of the conic ligament. Paramedian thyrotomy on the left using a wheel and entering the laryngeal lumen. Checking the findings from the cranial and caudal side using 30° optics. Subsequent insertion subperichondrally on the right side. Inclusion in the preparation of the inner perichondrium of the thyroid cartilage. Inclusion in the preparation of a part of the sinus morgagni and the subglottic slope of the right vocal fold in order to create a large safety margin. Posteriorly, the vocal process of the arytenoid cartilage is removed together with the preparation. The anterior third of the left vocal fold is then included in the preparation. Removal of marginal samples (right subglottis, right supraglottis, right arytenoid cartilage, right base of the wound, left anterior vocal fold), which are found to be free of tumor and dysplasia by the pathology colleagues. Hemostasis in the area of the tumor resection using bipolar coagulation. Drilling of four holes using a Lindemann reamer on the thyroid cartilage and fitting of a size 16 Keel prosthesis. Suture adaptation of the conic ligament. Creation of a flap. Suture adaptation of the prelaryngeal musculature in the midline. Platysma suture. Single-button skin suture, application of a pressure bandage. Completion of the procedure without complications. Placement of a nasogastric feeding tube through which the patient is to be fed for the next 5 days. Control MLE and, depending on the findings, removal of the cone planned in 6 weeks.

379/InvasionFront_CD3_block13_x3_y6_patient379_0.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 10994.2,
+    "Centroid Y µm": 14117.5,
+    "Num Detections": 15108,
+    "Num Negative": 11342,
+    "Num Positive": 3766,
+    "Positive %": 24.93,
+    "Num Positive per mm^2": 2323.3
+  }
+}

379/InvasionFront_CD3_block13_x4_y6_patient379_1.json

@@ -0,0 +1,11 @@
+{
+  "patient_tma_measurements": {
+    "Centroid X µm": 13542.8,
+    "Centroid Y µm": 14217.5,
+    "Num Detections": 16617,
+    "Num Negative": 15091,
+    "Num Positive": 1526,
+    "Positive %": 9.183,
+    "Num Positive per mm^2": 891.64
+  }
+}