text
stringlengths 31
999
| source
stringclasses 5
values |
|---|---|
An urban oasis is a public open space, park, or plaza which is located in between buildings or formed by surrounding buildings in an urban setting. It can exist in any kind of culture. There are various sizes of urban oases
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Urban sprawl (also known as suburban sprawl or urban encroachment) is defined as "the spreading of urban developments (such as houses and shopping centers) on undeveloped land near a city". Urban sprawl has been described as the unrestricted growth in many urban areas of housing, commercial development, and roads over large expanses of land, with little concern for urban planning. In addition to describing a special form of urbanization, the term also relates to the social and environmental consequences associated with this development
|
https://huggingface.co/datasets/fmars/wiki_stem
|
YVR Sustainability is an operations department at Vancouver International Airport that is concerned with airport green initiatives. Its focus is to expand the airport quality of YVR without harm to the environment or affecting the community in a negative way. It focuses on a variety of initiatives having to do with heating, transport, energy consumption, recycling and noise
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The 100 percent corner is the busiest area in a city. Often it is a crossroads of several major streets, and the place with the highest land value and/or where grid plan numbering is based upon. The term is also used for the place for ideal real estate projects, sometimes considered the intersection of two highways in a suburban area
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Accessibility is the design of products, devices, services, vehicles, or environments so as to be usable by people with disabilities. The concept of accessible design and practice of accessible development ensures both "direct access" (i. e
|
https://huggingface.co/datasets/fmars/wiki_stem
|
An alley house is a style of house constructed in an alley that serves the back of other homes rather than a larger residential street. Often, these take the form of terraced houses, which can maximize the use of the spatial limitations of an alley. Alley houses were prevalent in the late nineteenth and early twentieth centuries; their small size made them less expensive in high demand property markets
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Arcology, a portmanteau of "architecture" and "ecology", is a field of creating architectural design principles for very densely populated and ecologically low-impact human habitats.
The term was coined in 1969 by architect Paolo Soleri, who believed that a completed arcology would provide space for a variety of residential, commercial, and agricultural facilities while minimizing individual human environmental impact. These structures have been largely hypothetical, as no arcology, even one envisioned by Soleri himself, has yet been built
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Beautification is the process of making visual improvements to a town, city, or urban area. This most often involves planting trees, shrubbery, and other greenery, but frequently also includes adding decorative or historic-style street lights and other lighting and replacing broken pavement, often with brick or other natural materials. Old-fashioned cobblestones are sometimes used for crosswalks; they provide the additional benefit of slowing motorists
|
https://huggingface.co/datasets/fmars/wiki_stem
|
A boomtown is a community that undergoes sudden and rapid population and economic growth, or that is started from scratch. The growth is normally attributed to the nearby discovery of a precious resource such as gold, silver, or oil, although the term can also be applied to communities growing very rapidly for different reasons, such as a proximity to a major metropolitan area, huge construction project, or attractive climate.
First boomtowns
Early boomtowns, such as Leeds, Liverpool, and Manchester, experienced a dramatic surge in population and economic activity during the Industrial Revolution at the turn of the 19th century
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Brownfield refers to land that is abandoned or underutilized due to pollution from industrial use. The specific definition of brownfield land varies and is decided by policy makers and/or land developers within different countries. The main difference in definitions of whether a piece of land is considered a brownfield or not depends on the presence or absence of pollution
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Build-out is an urban planner’s estimate of the amount and location of potential development for an area. Sometimes called a "lot-yield analysis", build-out is one step of the land use planning process. Evaluation of potential development impacts begins with a build-out analysis
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The term built environment refers to human-made conditions and is often used in architecture, landscape architecture, urban planning, public health, sociology, and anthropology, among others. These curated spaces provide the setting for human activity and were created to fulfill human desires and needs. The term can refer to a plethora of components including the traditionally associated buildings, cities, public infrastructure, transportation, open space, as well as more conceptual components like farmlands, dammed rivers, wildlife management, and even domesticated animals
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Californication is a portmanteau of California and fornication, appearing in Time on May 6, 1966 and written about on August 21, 1972, additionally seen on bumper stickers in the U. S. states of Idaho, Washington, Colorado, Oklahoma, and Texas
|
https://huggingface.co/datasets/fmars/wiki_stem
|
A canal estate, canal development, waterway estate or marine suburb is a residential subdivision made up of canals and reclaimed land, such that many or all of the lots can incorporate a private mooring or boat ramp. Canal estates are typically constructed on floodplains or swampland in estuaries, providing ready access to larger waterways and the ocean. To build the estate, civil contractors will dredge parts of the site to create deep, navigable channels, and use the resulting fill to form islands and headlands above the flood level
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The Cartesian sky-scraper, designed by Le Corbusier in 1938, is a type of tower known for its modern and rational design. This type of modern administration building has its origin in the first sketches for the Pavillon de l'Esprit Nouveau in 1919, which proposed a cruciform shape for skyscrapers, radiating light and stability. In principle, the cruciform plan (with two axes) does not adapt itself to the path of the sun, which has only one axis
|
https://huggingface.co/datasets/fmars/wiki_stem
|
A city block, residential block, urban block, or simply block is a central element of urban planning and urban design.
A city block is the smallest group of buildings that is surrounded by streets, not counting any type of thoroughfare within the area of a building or comparable structure. City blocks are the space for buildings within the street pattern of a city, and form the basic unit of a city's urban fabric
|
https://huggingface.co/datasets/fmars/wiki_stem
|
City networks can either refer to a membership organization city leaders join to connect their city to other municipalities, or to a geographical concept used to describe inter-connectivity of cities on different levels (trade, railways, culture etc. ).
City networks in international cooperation
In the perspective of international cooperation, the term "city network" refers to a membership organization that cities join either to take part to specific projects, to be represented by geographical specificity, or to assert political commitments
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The City Protocol is a new open, global, and progressive working framework for cities worldwide to assess and improve performance in environmental sustainability, economic competitiveness, quality of life, and city services, by innovating and demonstrating new leadership models, new ways of engaging society, and by leveraging new information and communication technologies (ICT).
Many initiatives exist today on various indicators (quality, performance and life) and on normalization of trade. The City Protocol addresses the city under a systemic approach
|
https://huggingface.co/datasets/fmars/wiki_stem
|
City region is a term in use since about 1950 by urbanists, economists and urban planners to mean a metropolitan area and hinterland, often having a shared administration. Typically, it denotes a city, conurbation or urban zone with multiple administrative districts, but sharing resources like a central business district, labour market and transport network such that it functions as a single economic unit In studying human geography, urban and regional planning or the regional dynamics of business it is often worthwhile to have closer regard to dominant travel patterns during the working day (to the extent that these can be estimated and recorded) than to the rather arbitrary boundaries assigned to administrative bodies such as councils, prefectures, or localities defined merely to optimise postal services. Inevitably, city regions change their shapes over time and quite reasonably, politicians seek to redraw administrative boundaries by perceived geographic reality
|
https://huggingface.co/datasets/fmars/wiki_stem
|
A civic center or civic centre is a prominent land area within a community that is constructed to be its focal point or center. It usually contains one or more dominant public buildings, which may also include a government building. Recently, the term "civic center" has been used in reference to an entire central business district of a community or a major shopping center in the middle of a community
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Commercial areas in a city are areas, districts, or neighborhoods primarily composed of commercial buildings, such as a strip mall, office parks, downtown, central business district, financial district, "Main Street", or shopping centers. Commercial activity within cities includes the buying and selling of goods and services in retail businesses, wholesale buying and selling, financial establishments, and a wide variety of uses that are broadly classified as "business. " While commercial activities typically take up a relatively small amount of land, they are extremely important to a community's economy
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Community displacement is the movement of a population out of a neighborhood as formal or informal redevelopment occurs. It may be a result of gentrification, the informal redevelopment that occurs when new, and typically richer people, move into a neighborhood. It is the result of urban redevelopment of a residential neighborhood to non-residential uses including retail, education, healthcare, and transportation
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Community Greens, sometimes referred to as backyard commons, urban commons, or pocket neighborhoods, are shared open green spaces on the inside of city blocks, created either when residents merge backyard space or reclaim underutilized urban land such as vacant lots and alleyways. These shared spaces are communally used and managed only by the residents whose homes abut them. They are not a public park, a private backyard, or a community garden; however, they can function as all three
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Comprehensive planning is an ordered process that determines community goals and aspirations in terms of community development. The end product is called a comprehensive plan, also known as a general plan, or master plan. This resulting document expresses and regulates public policies on transportation, utilities, land use, recreation, and housing
|
https://huggingface.co/datasets/fmars/wiki_stem
|
A conscious city is a large built environment that is aware of the needs and activities of its inhabitants and responds to them. Research in conscious cities explores how architecture and urban design can better consider and respond to human needs through data analysis, artificial intelligence, and the application of cognitive sciences in design. While a smart city focuses on improving efficiency of services, a conscious city applies new technology and behavioral insight into improving an experience and its mental and physiological effects
|
https://huggingface.co/datasets/fmars/wiki_stem
|
A conurbation is a region comprising a number of metropolises, cities, large towns, and other urban areas which through population growth and physical expansion, have merged to form one continuous urban or industrially developed area. In most cases, a conurbation is a polycentric urbanised area in which transportation has developed to link areas. They create a single urban labour market or travel to work area
|
https://huggingface.co/datasets/fmars/wiki_stem
|
In urban planning, a historic core city or central city is the municipality with the largest 1940 population in the present metropolitan area (metropolitan statistical area). This term was retired by the US census bureau and replaced by the term principal city, which can include historic core cities and post WW2 cities. Metropolitan areas are no longer considered monocentric, but had become polycentric due to suburbanization of employment
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Coving is a method of Suburban planning used in subdivision and redevelopment of cities characterized by organic lot shapes and home placement along meandering setbacks. When combined with a new form of street patterns, lot area is increased and road area and length is reduced - a demonstrated average 25% compared to conventional suburban platting. Coving is used as an alternative to conventional urban "grid" and suburban land development layouts in order to enhance curb appeal, eliminate monotony, reduce costs, such as road surfacing and street length, while increasing the amount of land available for construction
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The creative city is a concept that argues creativity should be considered a strategic factor in urban development. In addition to cities being efficient and fair, a creative city provides places, experiences, favorites, attractions, and opportunities to foster creativity among its citizens.
Creativity and imagination in urban activities
The creative city, when introduced, was seen as aspirational; a clarion call to encourage open-mindedness and imagination implying a dramatic impact on organizational culture
|
https://huggingface.co/datasets/fmars/wiki_stem
|
This article was the subject of a Wiki Education Foundation-supported course assignment, between 26 August 2021 and 24 December 2021. Further details are available on the course page. Student editor(s): Andrew 43333
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Downtown is a term primarily used in North America by English speakers to refer to a city's sometimes commercial, cultural and often the historical, political and geographic heart. It is often synonymous with its central business district (CBD). Downtowns typically contain a small percentage of a city’s employment
|
https://huggingface.co/datasets/fmars/wiki_stem
|
"Eco-municipality" has a specific meaning. For a more general discussion of the sustainability of cities, see Sustainable city. An eco-municipality or eco-town is a local government area that has adopted ecological and social justice values in its charter
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The ecology of contexts is a term used in many disciplines and refers to the dynamic interplay of contexts and demands that constrain and define an entity.
Environmental ecology
An agroecosystem exists amid contexts including climate, soil, plant genetics, government policies, and the personal beliefs and predilections of the agriculturalist. Not only are these contexts too numerous to list in their entirety for any agroecosystem, but their interactions are so complex it is impossible to perfectly characterize a system, let alone predict the effect a given perturbation will have on the whole
|
https://huggingface.co/datasets/fmars/wiki_stem
|
An ecovillage is a traditional or intentional community with the goal of becoming more socially, culturally, economically, and/or ecologically sustainable. An ecovillage strives to produce the least possible negative impact on the natural environment through intentional physical design and resident behavior choices. It is consciously designed through locally owned, participatory processes to regenerate and restore its social and natural environments
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Ekistics is the science of human settlements including regional, city, community planning and dwelling design. Its major incentive was the emergence of increasingly large and complex conurbations, tending even to a worldwide city. The study involves every kind of human settlement, with particular attention to geography, ecology, human psychology, anthropology, culture, politics, and occasionally aesthetics
|
https://huggingface.co/datasets/fmars/wiki_stem
|
In geography and urban planning, elbow roomers are people who leave a city for the countryside to seek more land and greater freedom from governmental and neighborhood interference. Some are carrying out activities such as large-scale gardening, the raising of horses or other animals, or farming, or otherwise have a genuine need for the space. Others wish to pursue a rural lifestyle for reasons unrelated to space itself
|
https://huggingface.co/datasets/fmars/wiki_stem
|
An exurb (or alternately: exurban area) is an area outside the typically denser inner suburban area, at the edge of a metropolitan area, which has some economic and commuting connection to the metro area, low housing density, and growth. It shapes an interface between urban and rural landscapes holding a limited urban nature for its functional, economic, and social interaction with the urban center, due to its dominant residential character. Exurbs consist of "agglomerations of housing and jobs outside the municipal boundaries of a primary city" and beyond the surrounding suburbs
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Facadism, façadism, or façadomy is the architectural and construction practice where the facade of a building is designed or constructed separately from the rest of a building, or when only the facade of a building is preserved with new buildings erected behind or around it.
There are aesthetic and historical reasons for preserving building facades. Facadism can be the response to the interiors of a building becoming unusable, such as being damaged by fire
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Floor area ratio (FAR) is the ratio of a building's total floor area (gross floor area) to the size of the piece of land upon which it is built. It is often used as one of the regulations in city planning along with the building-to-land ratio. The terms can also refer to limits imposed on such a ratio through zoning
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The fused grid is a street network pattern first proposed in 2002 and subsequently applied in Calgary, Alberta (2006) and Stratford, Ontario (2004). It represents a synthesis of two well known and extensively used network concepts: the "grid" and the "Radburn" pattern, derivatives of which are found in most city suburbs. Both concepts were conscious attempts to organize urban space for habitation
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Gateway communities are cities or towns that lie just outside major tourist attractions such as national parks, wilderness areas, or nature resort areas. Examples of gateway communities in the US include Jackson, Wyoming; Tusayan, Arizona; and Gardiner, Montana.
These places provide services for guests of the adjacent attractions, such as gas, food, and lodging, and as a result rely upon these attractions to sustain their economy
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Max-interacting transcriptional repressor MAD4 is a protein that in humans is encoded by the MXD4 gene.
Function
This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex
|
https://huggingface.co/datasets/fmars/wiki_stem
|
MAX-interacting protein 1 is a protein that in humans is encoded by the MXI1 gene.
Function
Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Myb genes are part of a large gene family of transcription factors found in animals and plants. In humans, it includes Myb proto-oncogene like 1 and Myb-related protein B in addition to MYB proper. Members of the extended SANT/Myb family also include the SANT domain and other similar all-helical homeobox-like domains
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Myb-related protein B is a protein that in humans is encoded by the MYBL2 gene.
Function
The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Myc is a family of regulator genes and proto-oncogenes that code for transcription factors. The Myc family consists of three related human genes: c-myc (MYC), l-myc (MYCL), and n-myc (MYCN). c-myc (also sometimes referred to as MYC) was the first gene to be discovered in this family, due to homology with the viral gene v-myc
|
https://huggingface.co/datasets/fmars/wiki_stem
|
MYC proto-oncogene, bHLH transcription factor is a protein that in humans is encoded by the MYC gene which is a member of the myc family of transcription factors. The protein contains basic helix-loop-helix (bHLH) structural motif.
Function
This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation
|
https://huggingface.co/datasets/fmars/wiki_stem
|
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene. MYCL1 is a bHLH (basic helix-loop-helix) transcription factor implicated in lung cancer.
Interactions
MYCL1 has been shown to interact with MAX
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene.
It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs)
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Myogenic factor 6 (also known as Mrf4 or herculin) is a protein that in humans is encoded by the MYF6 gene.
This gene is also known in the biomedical literature as MRF4 and herculin. MYF6 is a myogenic regulatory factor (MRF) involved in the process known as myogenesis
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Myocyte-specific enhancer factor 2A is a protein that in humans is encoded by the MEF2A gene. MEF2A is a transcription factor in the Mef2 family. In humans it is located on chromosome 15q26
|
https://huggingface.co/datasets/fmars/wiki_stem
|
MyoD, also known as myoblast determination protein 1, is a protein in animals that plays a major role in regulating muscle differentiation. MyoD, which was discovered in the laboratory of Harold M. Weintraub, belongs to a family of proteins known as myogenic regulatory factors (MRFs)
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Myogenic regulatory factors (MRF) are basic helix-loop-helix (bHLH) transcription factors that regulate myogenesis: MyoD, Myf5, myogenin, and MRF4. These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif. They dimerize with other HLH containing proteins through an HLH-HLH interaction
|
https://huggingface.co/datasets/fmars/wiki_stem
|
N-myc proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is encoded by the MYCN gene.
Function
The MYCN gene is a member of the MYC family of transcription factors and encodes a protein with a basic helix-loop-helix (bHLH) domain. This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA
|
https://huggingface.co/datasets/fmars/wiki_stem
|
In molecular biology, the NELF (negative elongation factor) is a four-subunit protein complex (NELF-A, NELF-B, NELF-C/NELF-D, and NELF-E) that negatively impacts transcription by RNA polymerase II (Pol II) by pausing about 20-60 nucleotides downstream from the transcription start site (TSS).
Structure
The NELF has four subunits within its complex which are the following: NELF-A, NELF-B, NELF-C/NELF-D, and NELF-E. The NELF-A subunit is encoded by the gene WHSC2 (Wolf-Hirschhorn syndrome candidate 2)
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.
Function
This gene encodes a member of the neuroD family of neurogenic basic helix-loop-helix (bHLH) proteins. Expression of this gene can induce transcription from neuron-specific promoters, such as the GAP-43 promoter, which contain a specific DNA sequence known as an E-box
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) is a protein complex that controls transcription of DNA, cytokine production and cell survival. NF-κB is found in almost all animal cell types and is involved in cellular responses to stimuli such as stress, cytokines, free radicals, heavy metals, ultraviolet irradiation, oxidized LDL, and bacterial or viral antigens. NF-κB plays a key role in regulating the immune response to infection
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of the immune system. NFAT is also involved in the development of cardiac, skeletal muscle, and nervous systems
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor of activated T-cells 5, also known as NFAT5 and sometimes TonEBP, is a human gene that encodes a transcription factor that regulates the expression of genes involved in the osmotic stress. The product of this gene is a member of the nuclear factors of activated T cells (NFAT) family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor of activated T-cells, cytoplasmic 1 is a protein that in humans is encoded by the NFATC1 gene.
Function
The product of this gene is a component of the nuclear factor of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation, and an inducible nuclear component
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor of activated T-cells, cytoplasmic 2 is a protein that in humans is encoded by the NFATC2 gene.
Function
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR)
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor of activated T-cells, cytoplasmic 3 is a protein that in humans is encoded by the NFATC3 gene.
Function
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor of activated T-cells, cytoplasmic 4 is a protein that in humans is encoded by the NFATC4 gene.
Function
The product of this gene is a member of the nuclear factors of activated T cells DNA-binding transcription complex. This complex consists of at least two components: a preexisting cytosolic component that translocates to the nucleus upon T cell receptor (TCR) stimulation and an inducible nuclear component
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Transcription factor NF-E2 45 kDa subunit is a protein that in humans is encoded by the NFE2 gene. It is involved in megakaryocyte production.
Interactions
NFE2 has been shown to interact with CREB-binding protein
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor erythroid 2-related factor 1 (Nrf1) also known as nuclear factor erythroid-2-like 1 (NFE2L1) is a protein that in humans is encoded by the NFE2L1 gene. Since NFE2L1 is referred to as Nrf1, it is often confused with nuclear respiratory factor 1 (Nrf1).
NFE2L1 is a cap ‘n’ collar, basic-leucine zipper (bZIP) transcription factor
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor erythroid 2-related factor 2 (NRF2), also known as nuclear factor erythroid-derived 2-like 2, is a transcription factor that in humans is encoded by the NFE2L2 gene. NRF2 is a basic leucine zipper (bZIP) protein that may regulate the expression of antioxidant proteins that protect against oxidative damage triggered by injury and inflammation, according to preliminary research. In vitro, NRF2 binds to antioxidant response elements (AREs) in the promoter regions of genes encoding cytoprotective proteins
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor (erythroid 2)-like factor 3, also known as NFE2L3 or 'NRF3', is a transcription factor that in humans is encoded by the Nfe2l3 gene. Nrf3 is a basic leucine zipper (bZIP) transcription factor belonging to the Cap ‘n’ Collar (CNC) family of proteins. In 1989, the first CNC transcription factor NFE2L2 was identified
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor 1 A-type is a protein that in humans is encoded by the NFIA gene.
Function
Nuclear factor I (NFI) proteins constitute a family of dimeric DNA-binding proteins with similar, and possibly identical, DNA-binding specificity. They function as cellular transcription factors and as replication factors for adenovirus DNA replication
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor 1 B-type is a protein that in humans is encoded by the NFIB gene. NFIB haploinsufficiency is also associated with intellectual disability and macrocephaly, as are NFIA and NFIX.
Embryonic Development
The NFIB gene is a part of the NFI gene complex that includes three other genes (NFIA, NFIC and NFIX)
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor 1 X-type is a protein that in humans is encoded by the NFIX gene. NFI-X3, a splice variant of NFIX, regulates Glial fibrillary acidic protein and YKL-40 in astrocytes.
Interactions
Nfix has been shown to interact with SKI protein and it is also known to interact with AP-1
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear factor NF-kappa-B p105 subunit is a protein that in humans is encoded by the NFKB1 gene. This gene encodes a 105 kD protein which can undergo cotranslational processing by the 26S proteasome to produce a 50 kD protein. The 105 kD protein is a Rel protein-specific transcription inhibitor and the 50 kD protein is a DNA binding subunit of the NF-kappaB (NF-κB) protein complex
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Transcriptional repressor NF-X1 is a protein that in humans is encoded by the NFX1 gene. MHC class II gene expression is controlled primarily at the transcriptional level by transcription factors that bind to the X and Y boxes, two highly conserved elements in the proximal promoter of MHC class II genes. The protein encoded by this gene is a transcriptional repressor capable of binding to the conserved X box motif of HLA-DRA and other MHC class II genes in vitro
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear transcription factor Y subunit alpha is a protein that in humans is encoded by the NFYA gene.
Function
The protein encoded by this gene is one subunit of a trimeric complex NF-Y, forming a highly conserved transcription factor that binds to CCAAT motifs in the promoter regions in a variety of genes. Subunit NFYA associates with a tight dimer composed of the NFYB and NFYC subunits, resulting in a trimer that binds to DNA with high specificity and affinity
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear transcription factor Y subunit gamma is a protein that in humans is encoded by the NFYC gene.
Function
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit C, forms a tight dimer with the B subunit (NFYB), a prerequisite for subunit A (NFYA) association
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The NR4A1 gene is a transcription factor important in the development of cells that secrete the hormone insulin-like 3 (INSL3). In general, the NR4A gene family regulates cell growth and differentiation.
In humans, INSL3 aids in the regulation of testicular descent during fetal development
|
https://huggingface.co/datasets/fmars/wiki_stem
|
NK2 homeobox 1 (NKX2-1), also known as thyroid transcription factor 1 (TTF-1), is a protein which in humans is encoded by the NKX2-1 gene.
Function
Thyroid transcription factor-1 (TTF-1) is a protein that regulates transcription of genes specific for the thyroid, lung, and diencephalon. It is also known as thyroid specific enhancer binding protein
|
https://huggingface.co/datasets/fmars/wiki_stem
|
== Function ==
Nkx 2. 9 is a transcription factor responsible for the formation of the branchial and visceral motor neuron subtypes of cranial motor nerves in vertebrates. Nkx 2
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Homeobox protein Nkx-2. 2 is a protein that in humans is encoded by the NKX2-2 gene. Homeobox protein Nkx-2
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Homeobox protein Nkx-3. 1, also known as NKX3-1, NKX3, BAPX2, NKX3A and NKX3. 1 is a protein that in humans is encoded by the NKX3-1 gene located on chromosome 8p
|
https://huggingface.co/datasets/fmars/wiki_stem
|
NK3 homeobox 2 also known as NKX3-2 is a human gene. It is a homolog of bagpipe (bap) in Drosophila and therefore also known as Bapx1 (bagpipe homeobox homolog 1). The protein encoded by this gene is a homeodomain containing transcription factor
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Homeobox protein NOBOX, also known as newborn ovary homeobox protein, is a protein that in humans is encoded by the NOBOX gene. The official symbol (NOBOX) and the official full name (NOBOX oogenesis homeobox) are maintained by the HGNC. The NOBOX gene is conserved in chimpanzee, Rhesus monkey, cow, mouse, and rat
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Neuronal PAS domain protein 2 (NPAS2) also known as member of PAS protein 4 (MOP4) is a transcription factor protein that in humans is encoded by the NPAS2 gene. NPAS2 is paralogous to CLOCK, and both are key proteins involved in the maintenance of circadian rhythms in mammals. In the brain, NPAS2 functions as a generator and maintainer of mammalian circadian rhythms
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Nuclear respiratory factor 1, also known as Nrf1, Nrf-1, NRF1 and NRF-1, encodes a protein that homodimerizes and functions as a transcription factor which activates the expression of some key metabolic genes regulating cellular growth and nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication. The protein has also been associated with the regulation of neurite outgrowth. Alternate transcriptional splice variants, which encode the same protein, have been characterized
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Neural retina-specific leucine zipper protein is a protein that in humans is encoded by the NRL gene.
Function
This gene encodes a basic motif-leucine zipper transcription factor of the Maf subfamily. The encoded protein is conserved among vertebrates and is a critical intrinsic regulator of photoreceptor cell development and function
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The nuclear receptor 4A1 (NR4A1 for "nuclear receptor subfamily 4 group A member 1") also known as Nur77, TR3, and NGFI-B is a protein that in humans is encoded by the NR4A1 gene. Nuclear receptor 4A1 (NR4A1) is a member of the NR4A nuclear receptor family of intracellular transcription factors. NR4A1 is involved in cell cycle mediation, inflammation and apoptosis
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The nuclear receptor 4A2 (NR4A2) (nuclear receptor subfamily 4 group A member 2) also known as nuclear receptor related 1 protein (NURR1) is a protein that in humans is encoded by the NR4A2 gene. NR4A2 is a member of the nuclear receptor family of intracellular transcription factors.
NR4A2 plays a key role in the maintenance of the dopaminergic system of the brain
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The nuclear receptor 4A3 (NR4A3) (nuclear receptor subfamily 4, group A, member 3) also known as neuron-derived orphan receptor 1 (NOR1) is a protein that in humans is encoded by the NR4A3 gene. NR4A3 is a member of the nuclear receptor family of intracellular transcription factors.
NR4A3 plays a central regulatory role in cell proliferation, differentiation, mitochondrial respiration, metabolism and apoptosis
Interactions
NR4A3 has been shown to interact with SIX3
|
https://huggingface.co/datasets/fmars/wiki_stem
|
The NucleaRDB is a database of nuclear receptors. It contains data about the sequences, ligand binding constants and mutations of those proteins.
See also
Nuclear receptor
References
External links
https://web
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Oligodendrocyte transcription factor (OLIG2) is a basic helix-loop-helix (bHLH) transcription factor encoded by the Olig2 gene. The protein is of 329 amino acids in length, 32 kDa in size and contains one basic helix-loop-helix DNA-binding domain. It is one of the three members of the bHLH family
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Homeobox protein OTX2 is a protein that in humans is encoded by the OTX2 gene.
Function
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and plays a role in brain and sensory organ development
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Protein odd-skipped-related 1 is a transcription factor that in humans is encoded by the OSR1 gene. The OSR1 and OSR2 transcription factors participate in the normal development of body parts such as the kidney. Protein odd-skipped related 1 is a zinc-finger transcription factor that, in humans, is encoded by the OSR1 gene found on chromosome 2 (2p24
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Homeobox protein OTX1 is a protein that in humans is encoded by the OTX1 gene.
Function
This gene encodes a member of the bicoid sub-family of homeodomain-containing transcription factors. The encoded protein acts as a transcription factor and may play a role in brain and sensory organ development
|
https://huggingface.co/datasets/fmars/wiki_stem
|
p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation
|
https://huggingface.co/datasets/fmars/wiki_stem
|
In evolutionary developmental biology, Paired box (Pax) genes are a family of genes coding for tissue specific transcription factors containing an N-terminal paired domain and usually a partial, or in the case of four family members (PAX3, PAX4, PAX6 and PAX7), a complete homeodomain to the C-terminus. An octapeptide as well as a Pro-Ser-Thr-rich C terminus may also be present. Pax proteins are important in early animal development for the specification of specific tissues, as well as during epimorphic limb regeneration in animals capable of such
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Paired box protein Pax-1 is a protein that in humans is encoded by the PAX1 gene.
Function
This gene is a member of the paired box (PAX) family of transcription factors which are essential during fetal development. It is required for the development of the ventral vertebral column
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Paired box gene 4, also known as PAX4, is a protein which in humans is encoded by the PAX4 gene.
Function
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically contain a paired box domain, an octapeptide, and a paired-type homeodomain
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Paired box protein Pax-5 is a protein that in humans is encoded by the PAX5 gene.
Function
The PAX5 gene is a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding domain, known as the paired box
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Paired box protein Pax-7 is a protein that in humans is encoded by the PAX7 gene.
Function
Pax-7 plays a role in neural crest development and gastrulation, and it is an important factor in the expression of neural crest markers such as Slug, Sox9, Sox10 and HNK-1. PAX7 is expressed in the palatal shelf of the maxilla, Meckel's cartilage, mesencephalon, nasal cavity, nasal epithelium, nasal capsule and pons
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Paired box gene 8, also known as PAX8, is a protein which in humans is encoded by the PAX8 gene.
Function
This gene is a member of the paired box (PAX) family of transcription factors. Members of this gene family typically encode proteins which contain a paired box domain, an octapeptide, and a paired-type homeodomain
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Paired box gene 9, also known as PAX9, is a protein which in humans is encoded by the PAX9 gene. It is also found in other mammals.
Expression and function
This gene is a member of the paired box (PAX) family of transcription factors
|
https://huggingface.co/datasets/fmars/wiki_stem
|
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.