id stringlengths 40 40 | source stringclasses 9
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caae35392be79c5a627cb645104249e4f6956715 | wikidoc | LIG4 | LIG4
DNA ligase 4 is an enzyme that in humans is encoded by the LIG4 gene.
# Function
The protein encoded by this gene is an ATP-dependent DNA ligase that joins double-strand breaks during the non-homologous end joining pathway of double-strand break repair. It is also essential for V(D)J recombination. Lig4 forms a... | LIG4
DNA ligase 4 is an enzyme that in humans is encoded by the LIG4 gene.[1]
# Function
The protein encoded by this gene is an ATP-dependent DNA ligase that joins double-strand breaks during the non-homologous end joining pathway of double-strand break repair. It is also essential for V(D)J recombination. Lig4 for... | https://www.wikidoc.org/index.php/LIG4 | |
5b6b83445ef985cbdd35f8a0b530f61e11985d88 | wikidoc | LIM2 | LIM2
Lens fiber membrane intrinsic protein is a protein that in humans is encoded by the LIM2 gene.
The mammalian lens fiber cell membrane contains 5 major proteins ranging from 70 kD to 19 kD in size. The specific function of these proteins is unknown. Some of them have been shown to be involved in the formation of ca... | LIM2
Lens fiber membrane intrinsic protein is a protein that in humans is encoded by the LIM2 gene.[1][2]
The mammalian lens fiber cell membrane contains 5 major proteins ranging from 70 kD to 19 kD in size. The specific function of these proteins is unknown. Some of them have been shown to be involved in the formatio... | https://www.wikidoc.org/index.php/LIM2 | |
b4a8caffc022c8ed5c45bc5bd6cc139ac5124e49 | wikidoc | LL37 | LL37
LL-37 (or CAP-18 for cathelicidin antimicrobial peptide, 18 kDa) is a gene encoding for the only member of the human cathelicidin family. Cathelicidin-related antimicrobial peptides are a family of polypeptides found in lysosomes of macrophages and polymorphonuclear leukocytes (PMNs), and keratinocytes. Cathelicid... | LL37
LL-37 (or CAP-18 for cathelicidin antimicrobial peptide, 18 kDa) is a gene encoding for the only member of the human cathelicidin family. Cathelicidin-related antimicrobial peptides are a family of polypeptides found in lysosomes of macrophages and polymorphonuclear leukocytes (PMNs), and keratinocytes.[1] Cathel... | https://www.wikidoc.org/index.php/LL37 | |
d99c08ef0e9d8a9da129de5ebb05a0ba91af57f3 | wikidoc | LMNA | LMNA
Lamin A/C also known as LMNA is a protein that in humans is encoded by the LMNA gene. Lamin A/C belongs to the lamin family of proteins.
# Function
In the setting of ZMPSTE24 deficiency, the final step of lamin processing does not occur, resulting in an accumulation of farnesyl-prelamin A. In Hutchinson–Gilford p... | LMNA
Lamin A/C also known as LMNA is a protein that in humans is encoded by the LMNA gene.[1][2] Lamin A/C belongs to the lamin family of proteins.
# Function
[3]
In the setting of ZMPSTE24 deficiency, the final step of lamin processing does not occur, resulting in an accumulation of farnesyl-prelamin A. In Hutchinso... | https://www.wikidoc.org/index.php/LMNA | |
8950a34c755a17e37acd3f7f8eb210b74a2bbc94 | wikidoc | LMO2 | LMO2
LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene.
# Function
LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropoiesi... | LMO2
LIM domain only 2 (rhombotin-like 1), also known as LMO2, RBTNL1, RBTN2, RHOM2, LIM Domain Only Protein 2, TTG2, and T-Cell Translocation Protein 2, is a protein which in humans is encoded by the LMO2 gene.[1]
# Function
LMO2 encodes a cysteine-rich, two LIM domain protein that is required for yolk sac erythropo... | https://www.wikidoc.org/index.php/LMO2 | |
84e75bd8549679b7fbe149cd084356e539fa37d7 | wikidoc | LMO4 | LMO4
LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.
LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple ATTT m... | LMO4
LIM domain transcription factor LMO4 is a protein that in humans is encoded by the LMO4 gene.[1]
LIM domain only 4 is a cysteine-rich, two LIM domain-containing protein that may play a role as a transcriptional regulator or possibly an oncogene. Its mRNA is characterized by a GC-rich 5' region and by multiple AT... | https://www.wikidoc.org/index.php/LMO4 | |
c279739b7a4c3c2486143d0539c3af1bcfa6a2bb | wikidoc | LQT1 | LQT1
# Overview
LQT1 is the most common subtype of long QT syndrome making up to 55% of all cases of long QT syndrome. It often presents as a cardiac event that occurs after exercise, and especially during underwater exercise such as swimming or diving. Homozygous recessive mutations in the gene for LQT1 appear to c... | LQT1
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
# Overview
LQT1 is the most common subtype of long QT syndrome making up to 55% of all cases of long QT syndrome. It often presents as a cardiac event that occurs after exercise, and especially during underwater exercise such as swimming or diving. Homozygous ... | https://www.wikidoc.org/index.php/LQT1 | |
5e35d54605837fed3a18b5c7070e51d8d629ca6f | wikidoc | LQT2 | LQT2
# Overview
LQT2 is the second most common subtype of mutations within long QT syndrome, occurring in 35-45% of LQTS patients. This subtype has been known to come to the attention of the cardiologist as a result of a cardiac event during the post-partum period, or after being triggered by an alarm clock or other a... | LQT2
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
# Overview
LQT2 is the second most common subtype of mutations within long QT syndrome, occurring in 35-45% of LQTS patients. This subtype has been known to come to the attention of the cardiologist as a result of a cardiac event during the post-partum period, o... | https://www.wikidoc.org/index.php/LQT2 | |
2876f4dbc65dea1514d186fdf23996f4b08ccdd8 | wikidoc | LQT3 | LQT3
# Overview
LQT3 is the third most common subtype of long QT syndrome, occurring in 5-10% of LQTS cases. It is most commonly associated with cardiac events that occur during sleep. It is also associated with Brugada syndrome and sudden infant death syndrome. This subtype is highly likely to show shortening of the ... | LQT3
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
# Overview
LQT3 is the third most common subtype of long QT syndrome, occurring in 5-10% of LQTS cases. It is most commonly associated with cardiac events that occur during sleep. It is also associated with Brugada syndrome and sudden infant death syndrome. This... | https://www.wikidoc.org/index.php/LQT3 | |
7c62d386d38e1ee681a88bc3e4354a7e88ce11a6 | wikidoc | LQT4 | LQT4
# Overview
The LTQ4 subtype of long QT syndrome is caused by a mutation in the genes which code for proteins cause ankyrins. People with this mutation experience sinus bradycardia, junctional escape rhythms, atrial fibrillation, and sudden death after physical or emotional stress. Ankyrins are important proteins ... | LQT4
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [3]
# Overview
The LTQ4 subtype of long QT syndrome is caused by a mutation in the genes which code for proteins cause ankyrins. People with this mutation experience sinus bradycardia, junctional escape rhyth... | https://www.wikidoc.org/index.php/LQT4 | |
d60e9ef7575b502184ae65bf70148fa1a8d98e7b | wikidoc | LQT5 | LQT5
# Overview
LQT5 subtype of long QT syndrome is an autosomal dominant mutation that leads to a defect in the potassium channel. In its rare homozygous form it can cause Jervell and Lange-Nielsen syndrome.
# LQT5 Subtype
## Genetics and Pathophysiology
LQT5 is an autosomal dominant relatively uncommon form of LQT... | LQT5
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
# Overview
LQT5 subtype of long QT syndrome is an autosomal dominant mutation that leads to a defect in the potassium channel. In its rare homozygous form it can cause Jervell and Lange-Nielsen syndrome.
# LQT5 Subtype
## Genetics and Pathophysiology
LQT5 is a... | https://www.wikidoc.org/index.php/LQT5 | |
f1c936bd8092333a0863ae2d0f2758f24b01a488 | wikidoc | LQT6 | LQT6
# Overview
LQT6 is a rare form of long QT syndrome.
# LQT6 Subtype
LQT6 is an autosomal dominant relatively uncommon form of LQTS. It involves mutations in the gene KCNE2 which encodes for the potassium channel beta subunit MiRP1, constituting part of the IKr repolarizing K+ current.
## History and Symptoms
- S... | LQT6
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
# Overview
LQT6 is a rare form of long QT syndrome.
# LQT6 Subtype
LQT6 is an autosomal dominant relatively uncommon form of LQTS. It involves mutations in the gene KCNE2 which encodes for the potassium channel beta subunit MiRP1, constituting part of the IKr r... | https://www.wikidoc.org/index.php/LQT6 | |
348efdfd2e850278958cc719102a7953913d7a06 | wikidoc | LQT8 | LQT8
# Overview
LQT8 subtype of long QT syndrome, also known as Timothy's syndrome is due to mutations causing abnormalities in calcium channels. LQT8 is associated with the finding of syndactyly.
# LQT8 Subtype
Timothy's syndrome is due to mutations in the calcium channel Cav1.2 encoded by the gene CACNA1c. Since th... | LQT8
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]; Associate Editor(s)-in-Chief: Charmaine Patel, M.D. [3]
# Overview
LQT8 subtype of long QT syndrome, also known as Timothy's syndrome is due to mutations causing abnormalities in calcium channels. LQT8 is associated with the finding of syndactyly.
# LQT8 Subt... | https://www.wikidoc.org/index.php/LQT8 | |
b41034f3e67cb81ff833e27532eb22819025d854 | wikidoc | LQT9 | LQT9
# Overview
LQT9 subtype is a variant of long QT syndrome, which causes abnormalities in a membrane protein called caveolin.
# LQT9
This newly discovered variant is caused by mutations in the membrane structural protein,caveolin-3. Caveolins form specific membrane domains called caveolae in which among others th... | LQT9
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [2]
# Overview
LQT9 subtype is a variant of long QT syndrome, which causes abnormalities in a membrane protein called caveolin.
# LQT9
This newly discovered variant is caused by mutations in the membrane structural protein,caveolin-3. Caveolins form specific membr... | https://www.wikidoc.org/index.php/LQT9 | |
a83152f8075eba98bd78f66a3b89f70755d3bf0e | wikidoc | LRBA | LRBA
Lipopolysaccharide-responsive and beige-like anchor protein is a protein that in humans is encoded by the LRBA gene.
Patients with Chediak-Higashi syndrome (CHS1; MIM 214500) suffer from a systemic immunodeficiency involving defects in polarized trafficking of vesicles in a number of immune system cell types. In m... | LRBA
Lipopolysaccharide-responsive and beige-like anchor protein is a protein that in humans is encoded by the LRBA gene.[1][2][3]
Patients with Chediak-Higashi syndrome (CHS1; MIM 214500) suffer from a systemic immunodeficiency involving defects in polarized trafficking of vesicles in a number of immune system cell t... | https://www.wikidoc.org/index.php/LRBA | |
94eb5d1eb0e1922e1acddae4984ccc92c9499ffa | wikidoc | LRG1 | LRG1
Leucine-rich alpha-2-glycoprotein 1 is a protein which in humans is encoded by the gene LRG1.
# Function
The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed durin... | LRG1
Leucine-rich alpha-2-glycoprotein 1 is a protein which in humans is encoded by the gene LRG1.[1]
# Function
The leucine-rich repeat (LRR) family of proteins, including LRG1, have been shown to be involved in protein-protein interaction, signal transduction, and cell adhesion and development. LRG1 is expressed d... | https://www.wikidoc.org/index.php/LRG1 | |
cfeb1b534d201dd1d392044bec0e1328ef1a641b | wikidoc | LRP1 | LRP1
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, the... | LRP1
Low density lipoprotein receptor-related protein 1 (LRP1), also known as alpha-2-macroglobulin receptor (A2MR), apolipoprotein E receptor (APOER) or cluster of differentiation 91 (CD91), is a protein forming a receptor found in the plasma membrane of cells involved in receptor-mediated endocytosis. In humans, th... | https://www.wikidoc.org/index.php/LRP1 | |
eecf1fda0cba5aa49405eaba2a30a6f36e2b87fe | wikidoc | LRP2 | LRP2
Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a protein which in humans is encoded by the LRP2 gene.
# Function
LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin and later LRP2. LRP2/me... | LRP2
Low density lipoprotein-related protein 2 also known as LRP2 or megalin is a protein which in humans is encoded by the LRP2 gene.[1][2][3]
# Function
LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin[4] and later ... | https://www.wikidoc.org/index.php/LRP2 | |
329deb8280bbfe62d7a3fafb37334b3e83cd00f4 | wikidoc | LRP5 | LRP5
Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene. LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mutation cau... | LRP5
Low-density lipoprotein receptor-related protein 5 is a protein that in humans is encoded by the LRP5 gene.[1][2][3] LRP5 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway. Mutations in LRP5 can lead to considerable changes in bone mass. A loss-of-function mu... | https://www.wikidoc.org/index.php/LRP5 | |
482da908e09e66327fc21aa1c9314b24451b4a12 | wikidoc | LRP6 | LRP6
Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene. LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.
# Structure
LRP6 is a transmembrane low-density lipoprotein receptor that shares a similar stru... | LRP6
Low-density lipoprotein receptor-related protein 6 is a protein that in humans is encoded by the LRP6 gene.[1][2] LRP6 is a key component of the LRP5/LRP6/Frizzled co-receptor group that is involved in canonical Wnt pathway.
# Structure
LRP6 is a transmembrane low-density lipoprotein receptor that shares a simil... | https://www.wikidoc.org/index.php/LRP6 | |
343ad3340d48f97c612865332cc6320a0f10de66 | wikidoc | LSM2 | LSM2
U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the LSM2 gene.
# Function
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which consists of ... | LSM2
U6 snRNA-associated Sm-like protein LSm2 is a protein that in humans is encoded by the LSM2 gene.[1][2][3]
# Function
Sm-like proteins were identified in a variety of organisms based on sequence homology with the Sm protein family (see SNRPD2; MIM 601061). Sm-like proteins contain the Sm sequence motif, which co... | https://www.wikidoc.org/index.php/LSM2 | |
754ed6ae8615d21f2465407f23461bf3f0036a7b | wikidoc | LYK5 | LYK5
Protein kinase LYK5, also known as LYK5 or STRADα, is a human protein and also denotes the gene encoding it.
# Function
Endogenous LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in phosphorylation of both partners. Removal of endogenous LYK5 by small interfering RNA abrogates LKB1-induce... | LYK5
Protein kinase LYK5, also known as LYK5 or STRADα, is a human protein and also denotes the gene encoding it.[1][2]
# Function
Endogenous LKB1 and STRADα form a complex in which STRADα activates LKB1, resulting in phosphorylation of both partners. Removal of endogenous LYK5 by small interfering RNA abrogates LKB1... | https://www.wikidoc.org/index.php/LYK5 | |
170a18bd50846616a7216a3a3f7c95bba303f688 | wikidoc | Leaf | Leaf
In botany, a leaf is an above-ground plant organ specialized for photosynthesis. For this purpose, a leaf is typically flat (laminar) and thin, to expose the cells containing chloroplast to light over a broad area, and to allow light to penetrate fully into the tissues. Leaves are also the sites in most plants whe... | Leaf
Template:Pp-semi
In botany, a leaf is an above-ground plant organ specialized for photosynthesis. For this purpose, a leaf is typically flat (laminar) and thin, to expose the cells containing chloroplast to light over a broad area, and to allow light to penetrate fully into the tissues. Leaves are also the sites ... | https://www.wikidoc.org/index.php/Leaf | |
ff14e2acc3c3d0cca9b3ecd02e4b6342f0a81e17 | wikidoc | Lisp | Lisp
# Background
A lisp (O E wlisp, stammering) is a speech impediment, historically also known as sigmatism. Stereotypically, people with a lisp are unable to pronounce sibilants (like the sound ]), and replace them with interdentals (like the sound ]), though there are actually several kinds of lisp. The result is ... | Lisp
Template:DiseaseDisorder infobox
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
# Background
A lisp (O E wlisp, stammering)[1] is a speech impediment, historically also known as sigmatism.[2] Stereotypically, people with a lisp are unable to pronounce sibilants (like the sound [[Voiceless alveolar fricative|... | https://www.wikidoc.org/index.php/Lisp | |
4f65189be8b679a660ead6be24f621f41a706463 | wikidoc | Luck | Luck
Luck (also called fortuity) is a chance happening, or that which happens beyond a person's control. Luck can be good or bad.
# Luck as lack of control
Luck refers to that which happens beyond a person's control. This view incorporates phenomena that are chance happenings, a person's place of birth for example, bu... | Luck
Luck (also called fortuity) is a chance happening, or that which happens beyond a person's control. Luck can be good or bad.
# Luck as lack of control
Luck refers to that which happens beyond a person's control. This view incorporates phenomena that are chance happenings, a person's place of birth for example, b... | https://www.wikidoc.org/index.php/Luck | |
c4b3da298dddc9122083cef20a34f25589ae822f | wikidoc | Lung | Lung
The lung is the essential respiration organ in air-breathing vertebrates, the most primitive being the lungfish. Its principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide from the bloodstream into the atmosphere. This exchange of gases is accomplished in ... | Lung
Template:WikiDoc Cardiology News
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
The lung is the essential respiration organ in air-breathing vertebrates, the most primitive being the lungfish. Its principal function is to transport oxygen from the atmosphere into the bloodstream, and to release carbon dioxide... | https://www.wikidoc.org/index.php/Lung | |
94d930976fb433ce81078362863300e788544909 | wikidoc | Lust | Lust
Lust is any intense desire or craving for gratification and excitement. Lust can mean strictly sexual lust, although it is also common to speak of a "lust for men", "lust for blood (bloodlust for short)" or a "lust for power", or other goals and to "lust for love". The Greek word which translates as lust is epith... | Lust
Lust is any intense desire or craving for gratification and excitement. Lust can mean strictly sexual lust, although it is also common to speak of a "lust for men", "lust for blood (bloodlust for short)" or a "lust for power", or other goals and to "lust for love". The Greek word which translates as lust is epit... | https://www.wikidoc.org/index.php/Lust | |
e10d1cf588a9dc80df8543f886fbbb1ad9bf1ecb | wikidoc | MAFG | MAFG
Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene.
MafG is one of the small Maf proteins, which are basic region and basic leucine zipper (bZIP)-type transcription factors. The HUGO Gene Nomenclature Committee-approved gene name of MAFG is “v-maf avian ... | MAFG
Transcription factor MafG is a bZip Maf transcription factor protein that in humans is encoded by the MAFG gene.[1][2]
MafG is one of the small Maf proteins, which are basic region and basic leucine zipper (bZIP)-type transcription factors. The HUGO Gene Nomenclature Committee-approved gene name of MAFG is “v-maf... | https://www.wikidoc.org/index.php/MAFG | |
f2a541937b3f08c35d511a3a90aa6b81767d706e | wikidoc | MAFK | MAFK
Transcription factor MafK is a bZip Maf transcription factor protein that in humans is encoded by the MAFK gene.
MafK is one of the small Maf proteins, which are basic region and basic leucine zipper (bZIP)-type transcription factors. The HUGO Gene Nomenclature Committee-approved gene name of MAFK is “v-maf avian ... | MAFK
Transcription factor MafK is a bZip Maf transcription factor protein that in humans is encoded by the MAFK gene.[1][2]
MafK is one of the small Maf proteins, which are basic region and basic leucine zipper (bZIP)-type transcription factors. The HUGO Gene Nomenclature Committee-approved gene name of MAFK is “v-maf... | https://www.wikidoc.org/index.php/MAFK | |
99b8966f8ec68b47544b58d029c3ce22eb96dff9 | wikidoc | MAP4 | MAP4
Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtub... | MAP4
Microtubule-associated protein 4 is a protein that in humans is encoded by the MAP4 gene.[1]
The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and micr... | https://www.wikidoc.org/index.php/MAP4 | |
94a27c52d74d6ae668b1b5103cfc7f6f5b9ec2ad | wikidoc | MAS1 | MAS1
MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA,MAS,MGRA""), is a protein that in humans is encoded by the MAS1 gene.
The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural motif, w... | MAS1
MAS proto-oncogene, or MAS1 proto-oncogene, G protein-coupled receptor (MRGA,MAS,MGRA""), is a protein that in humans is encoded by the MAS1 gene.[1]
The structure of the MAS1 product indicates that it belongs to the class of receptors that are coupled to GTP-binding proteins and share a conserved structural moti... | https://www.wikidoc.org/index.php/MAS1 | |
a559f36de96b1c46fb8a42b7295e9e2682bf48e8 | wikidoc | MBD1 | MBD1
Methyl-CpG-binding domain protein 1 is a protein that in humans is encoded by the MBD1 gene. The protein encoded by MBD1 binds to methylated sequences in DNA, and thereby influences transcription. It binds to a variety of methylated sequences, and appears to mediate repression of gene expression. It has been sho... | MBD1
Methyl-CpG-binding domain protein 1 is a protein that in humans is encoded by the MBD1 gene.[1][2][3] The protein encoded by MBD1 binds to methylated sequences in DNA, and thereby influences transcription. It binds to a variety of methylated sequences, and appears to mediate repression of gene expression. It ha... | https://www.wikidoc.org/index.php/MBD1 | |
a99a0834bb4e42e97bdfb9df44e4b5453856fec6 | wikidoc | MBD3 | MBD3
Methyl-CpG-binding domain protein 3 is a protein that in humans is encoded by the MBD3 gene.
# Function
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins relat... | MBD3
Methyl-CpG-binding domain protein 3 is a protein that in humans is encoded by the MBD3 gene.[1][2][3]
# Function
DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear prot... | https://www.wikidoc.org/index.php/MBD3 | |
9ca5f048f2c187cbd9d0fc008b6f1d92ff6fb681 | wikidoc | MBD4 | MBD4
Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.
# Structure
Human MBD4 protein has 580 amino acids with a methyl-CpG-binding domain at amino acids 82–147 and a C-terminal DNA glycosylase domain at amino acids 426–580. These domains are separated by an intervening regi... | MBD4
Methyl-CpG-binding domain protein 4 is a protein that in humans is encoded by the MBD4 gene.[1][2][3]
# Structure
Human MBD4 protein has 580 amino acids with a methyl-CpG-binding domain at amino acids 82–147 and a C-terminal DNA glycosylase domain at amino acids 426–580.[4] These domains are separated by an int... | https://www.wikidoc.org/index.php/MBD4 | |
e2457d2fa48293dc3132ec5d637eaeea79b0738b | wikidoc | MBDB | MBDB
MBDB, or 3,4-methylenedioxy-alpha-ethyl-N-methylphenethylamine, is a lesser-known hallucinogenic phenethylamine. It is also known as "EDEN" or "Methyl-J." It is the alpha-ethyl-N-methyl analog of MDMA (Esctasy). It was first synthesized by David E. Nichols, a leading pharmacologist and chemist, and later tested ... | MBDB
MBDB, or 3,4-methylenedioxy-alpha-ethyl-N-methylphenethylamine, is a lesser-known hallucinogenic phenethylamine. It is also known as "EDEN" or "Methyl-J." It is the alpha-ethyl-N-methyl analog of MDMA (Esctasy). It was first synthesized by David E. Nichols, a leading pharmacologist and chemist, and later tested... | https://www.wikidoc.org/index.php/MBDB | |
d3cf20bb1adee4348510f3b7920a6b85974093df | wikidoc | MCEF | MCEF
MCEF or Major Cdk9-interacting elongation factor is a transcription factor related to Af4. It is the fourth member of the Af4 family (AFF) of transcription factors, involved in numerous pathologies, including Acute Lymphoblastic Leukemia (ALL), abnormal CNS development, breast cancer and azoospermia.
Because it a... | MCEF
MCEF or Major Cdk9-interacting elongation factor is a transcription factor related to Af4. It is the fourth member of the Af4 family (AFF) of transcription factors, involved in numerous pathologies, including Acute Lymphoblastic Leukemia (ALL), abnormal CNS development, breast cancer and azoospermia.
Because it ... | https://www.wikidoc.org/index.php/MCEF | |
e1823721beff530b63c6b341ecf38c3bed3013e2 | wikidoc | MCL1 | MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene.
# Function
The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified. The l... | MCL1
Induced myeloid leukemia cell differentiation protein Mcl-1 is a protein that in humans is encoded by the MCL1 gene.[1][2]
# Function
The protein encoded by this gene belongs to the Bcl-2 family. Alternative splicing occurs at this locus and two transcript variants encoding distinct isoforms have been identified... | https://www.wikidoc.org/index.php/MCL1 | |
cdfae99964906474c2eadfcc09304eac9e406ce7 | wikidoc | MCM6 | MCM6
DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene. MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.
# Function
The MCM complex consisting of MCM6 (this protein) and MCM... | MCM6
DNA replication licensing factor MCM6 is a protein that in humans is encoded by the MCM6 gene.[1] MCM6 is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication.
# Function
The MCM complex consisting of MCM6 (this protein) and... | https://www.wikidoc.org/index.php/MCM6 | |
defa2865ffb8a84a63292ec5605d872eac7caa73 | wikidoc | MCM8 | MCM8
DNA replication licensing factor MCM8 is a protein that in humans is encoded by the MCM8 gene.
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by t... | MCM8
DNA replication licensing factor MCM8 is a protein that in humans is encoded by the MCM8 gene.[1][2]
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex form... | https://www.wikidoc.org/index.php/MCM8 | |
f8cb31b0e527739fca419eed19125001252087a6 | wikidoc | MCMI | MCMI
The Millon Clinical Multiaxial Inventory-III (MCMI-III) is a psychological assessment tool intended to provide information on psychopathology, including specific disorders outlined in the DSM-IV. It is intended for adults (18 and over) with at least an 8th grade reading level. It is composed of 175 true-false ques... | MCMI
The Millon Clinical Multiaxial Inventory-III (MCMI-III) is a psychological assessment tool intended to provide information on psychopathology, including specific disorders outlined in the DSM-IV. It is intended for adults (18 and over) with at least an 8th grade reading level. It is composed of 175 true-false que... | https://www.wikidoc.org/index.php/MCMI | |
5240c018fd3c3c089d32da333a83d82584e97484 | wikidoc | MCPA | MCPA
MCPA (2-methyl-4-chlorophenoxy-acetic acid, IUPAC (4-chloro-2-methylphenoxy)acetic acid, C9H9ClO3) is a powerful and selective phenoxy herbicide. The pure compound is brown-colored powder.
# History
Synthesis of MCPA was first reported by Synerholme and Zimmerman in 1945 and by Templeman and Foster in 1946. Templ... | MCPA
Template:Chembox new
MCPA (2-methyl-4-chlorophenoxy-acetic acid, IUPAC (4-chloro-2-methylphenoxy)acetic acid, C9H9ClO3) is a powerful and selective phenoxy herbicide. The pure compound is brown-colored powder.
# History
Synthesis of MCPA was first reported by Synerholme and Zimmerman in 1945 and by Templeman an... | https://www.wikidoc.org/index.php/MCPA | |
18e7227c5f00219e1bae97a844a526706ae09009 | wikidoc | MDA5 | MDA5
MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene. MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is a se... | MDA5
MDA5 (Melanoma Differentiation-Associated protein 5) is a RIG-I-like receptor dsRNA helicase enzyme that in humans is encoded by the IFIH1 gene.[1] MDA5 is part of the RIG-I-like receptor (RLR) family, which also includes RIG-I and LGP2, and functions as a pattern recognition receptor (recognizing dsRNA) that is ... | https://www.wikidoc.org/index.php/MDA5 | |
6c5c67b6a4a2f7945a3be8b0a6c3d8a5cc14bb2e | wikidoc | MDC1 | MDC1
Mediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene located on the short arm (p) of chromosome 6. MDC1 protein is a regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damage. It is i... | MDC1
Mediator of DNA damage checkpoint protein 1 is a 2080 amino acid long protein that in humans is encoded by the MDC1 gene[1][2][3] located on the short arm (p) of chromosome 6. MDC1 protein is a regulator of the Intra-S phase and the G2/M cell cycle checkpoints and recruits repair proteins to the site of DNA damag... | https://www.wikidoc.org/index.php/MDC1 | |
e5d9938f7f4bcd97d5146c8d368865162a19269f | wikidoc | MDH1 | MDH1
Malate dehydrogenase, cytoplasmic also known as malate dehydrogenase 1 is an enzyme that in humans is encoded by the MDH1 gene.
# Function
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this... | MDH1
Malate dehydrogenase, cytoplasmic also known as malate dehydrogenase 1 is an enzyme that in humans is encoded by the MDH1 gene.[1]
# Function
Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by ... | https://www.wikidoc.org/index.php/MDH1 | |
c2b87bb8e477c251fe3c02a0b5606f5cb4308947 | wikidoc | MDM4 | MDM4
Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.
# Function
The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins ... | MDM4
Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.[1][2]
# Function
The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm pr... | https://www.wikidoc.org/index.php/MDM4 | |
fac00be98c1232abed7171ba3f6cb8055db12856 | wikidoc | MDN1 | MDN1
MDN1, midasin homolog (yeast) is a protein that in humans is encoded by the MDN1 gene.
# Model organisms
Model organisms have been used in the study of MDN1 function. A conditional knockout mouse line, called Mdn1tm1a(KOMP)Wtsi was generated as part of the International Knockout Mouse Consortium program — a high-... | MDN1
MDN1, midasin homolog (yeast) is a protein that in humans is encoded by the MDN1 gene.[1]
# Model organisms
Model organisms have been used in the study of MDN1 function. A conditional knockout mouse line, called Mdn1tm1a(KOMP)Wtsi[6][7] was generated as part of the International Knockout Mouse Consortium program... | https://www.wikidoc.org/index.php/MDN1 | |
23dab689a18f993fe2bfb14b1d60c69d0ed70139 | wikidoc | MDPV | MDPV
# Overview
Methylenedioxypyrovalerone, also known as MDPK or 1-(3,4-methylenedioxyphenyl)-2-pyrrolidinyl-pentan-1-one, is a stimulant drug which acts as a norepinephrine and dopamine reuptake inhibitor, reportedly with four times the potency of methylphenidate. This compound is reported to be used as a stimulant... | MDPV
# Overview
Methylenedioxypyrovalerone, also known as MDPK or 1-(3,4-methylenedioxyphenyl)-2-pyrrolidinyl-pentan-1-one, is a stimulant drug which acts as a norepinephrine and dopamine reuptake inhibitor, reportedly with four times the potency of methylphenidate. [1] This compound is reported to be used as a stimul... | https://www.wikidoc.org/index.php/MDPV | |
4b2619bb66e9f8da8473f70d942794859c2e600e | wikidoc | MECR | MECR
Trans-2-enoyl-CoA reductase, mitochondrial is an enzyme that in humans is encoded by the MECR gene.
# Structure
The MECR gene is located on the 1st chromosome, with its specific location being 1p35.3. The gene contains 15 exons. MECR encodes a 21.2 kDa protein that is composed of 189 amino acids; 10 peptides have... | MECR
Trans-2-enoyl-CoA reductase, mitochondrial is an enzyme that in humans is encoded by the MECR gene.[1][2][3]
# Structure
The MECR gene is located on the 1st chromosome, with its specific location being 1p35.3.[3] The gene contains 15 exons.[3] MECR encodes a 21.2 kDa protein that is composed of 189 amino acids; ... | https://www.wikidoc.org/index.php/MECR | |
5086d64725e493625fe993eda3e9a8a1e2a2cc21 | wikidoc | MED1 | MED1
Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene. MED1 functions as a nuclear receptor coactivator.
# Function
The activation of gene transcription is a multistep process that is ... | MED1
Mediator of RNA polymerase II transcription subunit 1 also known as DRIP205 or Trap220 is a subunit of the Mediator complex and is a protein that in humans is encoded by the MED1 gene.[1][2][3] MED1 functions as a nuclear receptor coactivator.
# Function
The activation of gene transcription is a multistep proces... | https://www.wikidoc.org/index.php/MED1 | |
d98a1f688cfcc8738d85b1042f7a0baa1d203835 | wikidoc | MEFV | MEFV
MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin). Pyrin is produced in certain white blood cells (neutrophils, eosinophils and monocytes) that play a role in inflammation and in fighting infection. Inside these white blood cells, py... | MEFV
MEFV (Mediterranean fever) is a human gene that provides instructions for making a protein called pyrin (also known as marenostrin). Pyrin is produced in certain white blood cells (neutrophils, eosinophils and monocytes) that play a role in inflammation and in fighting infection. Inside these white blood cells, p... | https://www.wikidoc.org/index.php/MEFV | |
4dd053e0f2448ae279fccd76caa00676b8fe8905 | wikidoc | MEN1 | MEN1
Menin is a protein that in humans is encoded by the MEN1 gene. Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome).
In vitro studies have shown that menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits transcrip... | MEN1
Menin is a protein that in humans is encoded by the MEN1 gene.[1] Menin is a putative tumor suppressor associated with multiple endocrine neoplasia type 1 (MEN-1 syndrome).[2]
In vitro studies have shown that menin is localized to the nucleus, possesses two functional nuclear localization signals, and inhibits tr... | https://www.wikidoc.org/index.php/MEN1 | |
b3f36cd55001fdeb00f6d6fbcd744b668b4a8dfd | wikidoc | MFN2 | MFN2
Mitofusin-2 is a protein that in humans is encoded by the MFN2 gene. Mitofusins are GTPases embedded in the outer membrane of the mitochondria. In mammals MFN1 and MFN2 are essential for mitochondrial fusion. In addition to the mitofusins, OPA1 regulates inner mitochondrial membrane fusion, and DRP1 is responsible... | MFN2
Mitofusin-2 is a protein that in humans is encoded by the MFN2 gene.[1][2] Mitofusins are GTPases embedded in the outer membrane of the mitochondria. In mammals MFN1 and MFN2 are essential for mitochondrial fusion.[3] In addition to the mitofusins, OPA1 regulates inner mitochondrial membrane fusion, and DRP1 is r... | https://www.wikidoc.org/index.php/MFN2 | |
9cae1106768d73725af9a7aea1673d75aa4372e3 | wikidoc | MFNG | MFNG
Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene,
a member of the fringe gene family which also includes the radical fringe (RFNG) and lunatic fringe (LFNG).
They all encode evolutionarily conserved proteins that act in the Notch receptor pathway to dema... | MFNG
Beta-1,3-N-acetylglucosaminyltransferase manic fringe is an enzyme that in humans is encoded by the MFNG gene,[1][2][3]
a member of the fringe gene family which also includes the radical fringe (RFNG) and lunatic fringe (LFNG).[4][5]
They all encode evolutionarily conserved proteins that act in the Notch receptor... | https://www.wikidoc.org/index.php/MFNG | |
85eddd1c41e81f03022db565202ed09d78796b2b | wikidoc | MKL1 | MKL1
MKL/megakaryoblastic leukemia 1 (also termed MRTFA/myocardin related transcription factor A) is a protein that in humans is encoded by the MKL1 gene.
# Function
l
The protein encoded by this gene interacts with the transcription factor serum response factor, a key regulator of smooth muscle cell differentiation. ... | MKL1
MKL/megakaryoblastic leukemia 1 (also termed MRTFA/myocardin related transcription factor A) is a protein that in humans is encoded by the MKL1 gene.[1][2][3][4]
# Function
l
The protein encoded by this gene interacts with the transcription factor serum response factor,[5] a key regulator of smooth muscle cell d... | https://www.wikidoc.org/index.php/MKL1 | |
99c53768e5a781be4a6014de08741bb7320f8877 | wikidoc | MKS1 | MKS1
Meckel syndrome, type 1 also known as MKS1 is a protein that in humans is encoded by the MKS1 gene.
# Function
The MKS1 protein along with meckelin are part of the flagellar apparatus basal body proteome and are required for cilium formation.
# Clinical significance
Mutations in the MKS1 are associated with Meck... | MKS1
Meckel syndrome, type 1 also known as MKS1 is a protein that in humans is encoded by the MKS1 gene.[1]
# Function
The MKS1 protein along with meckelin are part of the flagellar apparatus basal body proteome and are required for cilium formation.[2]
# Clinical significance
Mutations in the MKS1 are associated wi... | https://www.wikidoc.org/index.php/MKS1 | |
90fbb707186a846295a55e17e0b01480c5b1c24b | wikidoc | MLC1 | MLC1
Membrane protein MLC1 is a protein that in humans is encoded by the MLC1 gene.
MLC1 (also called WKL1) is the only human gene currently associated with megalencephalic leukoencephalopathy with subcortical cysts (MLC). Evidence exists for at least one other gene for MLC, but it has not been mapped or identified.
#... | MLC1
Membrane protein MLC1 is a protein that in humans is encoded by the MLC1 gene.[1][2]
MLC1 (also called WKL1[3][4]) is the only human gene currently associated with megalencephalic leukoencephalopathy with subcortical cysts (MLC).[5] Evidence exists for at least one other gene for MLC, but it has not been mapped o... | https://www.wikidoc.org/index.php/MLC1 | |
168b684d38b8d3304cd287691a873dfe53927b01 | wikidoc | MLH3 | MLH3
DNA mismatch repair protein Mlh3 is a protein that in humans is encoded by the MLH3 gene.
# Function
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. The prot... | MLH3
DNA mismatch repair protein Mlh3 is a protein that in humans is encoded by the MLH3 gene.[1][2]
# Function
This gene is a member of the MutL-homolog (MLH) family of DNA mismatch repair (MMR) genes. MLH genes are implicated in maintaining genomic integrity during DNA replication and after meiotic recombination. T... | https://www.wikidoc.org/index.php/MLH3 | |
b080aa3ea7c7e52d709269cf065c41502eb6bdf5 | wikidoc | MMAB | MMAB
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial is an enzyme that in humans is encoded by the MMAB gene.
# Function
This gene encodes an enzyme (cob(I)yrinic acid a,c-diamide adenosyltransferase) that catalyzes the final step in the conversion of vitamin B12 into adenosylcobalamin (AdoCbl), a vit... | MMAB
Cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial is an enzyme that in humans is encoded by the MMAB gene.[1][2][3]
# Function
This gene encodes an enzyme (cob(I)yrinic acid a,c-diamide adenosyltransferase) that catalyzes the final step in the conversion of vitamin B12 into adenosylcobalamin (AdoC... | https://www.wikidoc.org/index.php/MMAB | |
45cedc0e3c1430179dd3c56b1557fe697052b469 | wikidoc | MMP1 | MMP1
Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase is an enzyme that in humans is encoded by the MMP1 gene. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. MMP-1 was the first vertebrate collagenase both purified to homogeneity as... | MMP1
Matrix metalloproteinase-1 (MMP-1) also known as interstitial collagenase and fibroblast collagenase is an enzyme that in humans is encoded by the MMP1 gene.[1][2][3] The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[1] MMP-1 was the first vertebrate collagenase both purified to h... | https://www.wikidoc.org/index.php/MMP1 | |
6b42d41b41710efb94acbe97bc302d5677e00521 | wikidoc | MMP2 | MMP2
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene. The MMP2 gene is located on chromosome 16 at position 12.2.
# Function
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extra... | MMP2
72 kDa type IV collagenase also known as matrix metalloproteinase-2 (MMP-2) and gelatinase A is an enzyme that in humans is encoded by the MMP2 gene.[1] The MMP2 gene is located on chromosome 16 at position 12.2.[2]
# Function
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown o... | https://www.wikidoc.org/index.php/MMP2 | |
dbf1ee884c95ea8aadd7bcfb776583ef76f96947 | wikidoc | MMP3 | MMP3
Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. MMP-3 has an estimated molecular weight of 54 kDa.
# Function
Proteins of the matrix metalloproteinase (MMP)... | MMP3
Stromelysin-1 also known as matrix metalloproteinase-3 (MMP-3) is an enzyme that in humans is encoded by the MMP3 gene. The MMP3 gene is part of a cluster of MMP genes which localize to chromosome 11q22.3.[1] MMP-3 has an estimated molecular weight of 54 kDa.[2]
# Function
Proteins of the matrix metalloproteinas... | https://www.wikidoc.org/index.php/MMP3 | |
20a64e7aa8db933eaba0f91d9f19d3f56aa997ee | wikidoc | MMP7 | MMP7
Matrilysin also known as matrix metalloproteinase-7 (MMP-7), pump-1 protease (PUMP-1), or uterine metalloproteinase is an enzyme in humans that is encoded by the MMP7 gene.
Matrilysin was discovered by Sellers and Woessner in the uterus of the rat in 1988. The complementary DNA (cDNA) of human MMP7 was isolated i... | MMP7
Matrilysin also known as matrix metalloproteinase-7 (MMP-7), pump-1 protease (PUMP-1), or uterine metalloproteinase is an enzyme in humans that is encoded by the MMP7 gene.[1]
Matrilysin was discovered by Sellers and Woessner in the uterus of the rat in 1988.[2] The complementary DNA (cDNA) of human MMP7 was iso... | https://www.wikidoc.org/index.php/MMP7 | |
add4624d2bd02fdc1c1b7a85eaba906cbf6f1e2c | wikidoc | MMP9 | MMP9
Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene encodes for a signal peptide, ... | MMP9
Matrix metallopeptidase 9 (MMP-9), also known as 92 kDa type IV collagenase, 92 kDa gelatinase or gelatinase B (GELB), is a matrixin, a class of enzymes that belong to the zinc-metalloproteinases family involved in the degradation of the extracellular matrix. In humans the MMP9 gene [1] encodes for a signal pepti... | https://www.wikidoc.org/index.php/MMP9 | |
3d1fdc39d26cade197d70da028e8235ea21e3891 | wikidoc | MoCA | MoCA
# Overview
The Montreal Cognitive Assessment (MoCA) was created in 1996 by Dr. Ziad Nasreddine in Montreal, Canada. It was validated in the setting of mild cognitive impairment, and has subsequently been adopted in numerous other settings clinically.
The MoCA test is a one-page 30-point test administered in appr... | MoCA
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] ; Associate Editor(s)-in-Chief: Pratik Bahekar, MBBS [2]
# Overview
The Montreal Cognitive Assessment (MoCA) was created in 1996 by Dr. Ziad Nasreddine in Montreal, Canada. It was validated in the setting of mild cognitive impairment, and has subsequently been... | https://www.wikidoc.org/index.php/MOCA | |
f9b833cbdf347dbd36712e5546c06ed4a0477897 | wikidoc | MPPP | MPPP
MPPP (1-methyl-4-phenyl-4-propionoxypiperidine, Desmethylprodine) is an opioid analgesic drug. It is not used in clinical practice, but has been illegally manufactured for recreational drug use. It is an analog of meperidine (Demerol), but since it is not used in medicine, the DEA has labeled it a Schedule I drug ... | MPPP
MPPP (1-methyl-4-phenyl-4-propionoxypiperidine, Desmethylprodine) is an opioid analgesic drug. It is not used in clinical practice, but has been illegally manufactured for recreational drug use. It is an analog of meperidine (Demerol), but since it is not used in medicine, the DEA has labeled it a Schedule I drug... | https://www.wikidoc.org/index.php/MPPP | |
ee517ad48d47b42ab0f8aca2c39fe601538ea3e3 | wikidoc | MPTP | MPTP
MPTP (1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine) is a neurotoxin that causes permanent symptoms of Parkinson's disease by killing certain neurons in the substantia nigra of the brain. It is used to study the disease in monkeys.
While MPTP itself does not have opioid effects, it is related to MPPP, a synthetic o... | MPTP
Template:Chembox new
MPTP (1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine) is a neurotoxin that causes permanent symptoms of Parkinson's disease by killing certain neurons in the substantia nigra of the brain. It is used to study the disease in monkeys.
While MPTP itself does not have opioid effects, it is related ... | https://www.wikidoc.org/index.php/MPTP | |
bd10f48a92abe7592ea59443b1765eb7215cd326 | wikidoc | MRAS | MRAS
Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the MRAS gene on chromosome 3. It is ubiquitously expressed in many tissues and cell types. This protein functions as a signal transducer for a wide variety of signaling pathways, including th... | MRAS
Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the MRAS gene on chromosome 3.[1][2][3] It is ubiquitously expressed in many tissues and cell types.[4] This protein functions as a signal transducer for a wide variety of signaling pathways,... | https://www.wikidoc.org/index.php/MRAS | |
1f05df0d088099af1a9985fc0b4d2eb035fef6a5 | wikidoc | MSDS | MSDS
A material safety data sheet (MSDS) is a form containing data regarding the properties of a particular substance. An important component of product stewardship and workplace safety, it is intended to provide workers and emergency personnel with procedures for handling or working with that substance in a safe manne... | MSDS
A material safety data sheet (MSDS) is a form containing data regarding the properties of a particular substance. An important component of product stewardship and workplace safety, it is intended to provide workers and emergency personnel with procedures for handling or working with that substance in a safe mann... | https://www.wikidoc.org/index.php/MSDS | |
ef8612c52bdf49302cadddd4e99f19d7bd8cd770 | wikidoc | MSH2 | MSH2
DNA mismatch repair protein Msh2 also known as MutS protein homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a het... | MSH2
DNA mismatch repair protein Msh2 also known as MutS protein homolog 2 or MSH2 is a protein that in humans is encoded by the MSH2 gene, which is located on chromosome 2. MSH2 is a tumor suppressor gene and more specifically a caretaker gene that codes for a DNA mismatch repair (MMR) protein, MSH2, which forms a he... | https://www.wikidoc.org/index.php/MSH2 | |
c461f109ccd16638679939745ba525c2e39ee741 | wikidoc | MSH3 | MSH3
DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs in microsatellit... | MSH3
DNA mismatch repair protein, MutS Homolog 3 (MSH3) is a human homologue of the bacterial mismatch repair protein MutS that participates in the mismatch repair (MMR) system. MSH3 typically forms the heterodimer MutSβ with MSH2 in order to correct long insertion/deletion loops and base-base mispairs in microsatelli... | https://www.wikidoc.org/index.php/MSH3 | |
63a03cc0b950d9b1681cf9aa27e638f3a8e1ce6a | wikidoc | MSH4 | MSH4
MutS protein homolog 4 is a protein that in humans is encoded by the MSH4 gene.
# Function
The MSH4 and MSH5 proteins form a hetero-oligomeric structure (heterodimer) in yeast and humans. In the yeast Saccharomyces cerevisiae MSH4 and MSH5 act specifically to facilitate crossovers between homologous chromosomes ... | MSH4
MutS protein homolog 4 is a protein that in humans is encoded by the MSH4 gene.[1][2]
# Function
The MSH4 and MSH5 proteins form a hetero-oligomeric structure (heterodimer) in yeast and humans.[3][4][5] In the yeast Saccharomyces cerevisiae MSH4 and MSH5 act specifically to facilitate crossovers between homolog... | https://www.wikidoc.org/index.php/MSH4 | |
9fd1ee7ee8b1c9730604ca0eaa028672fef49a60 | wikidoc | MSH5 | MSH5
MutS protein homolog 5 is a protein that in humans is encoded by the MSH5 gene.
# Function
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae protein that participates in meiot... | MSH5
MutS protein homolog 5 is a protein that in humans is encoded by the MSH5 gene.[1][2][3][4]
# Function
This gene encodes a member of the mutS family of proteins that are involved in DNA mismatch repair or meiotic recombination processes. This protein is similar to a Saccharomyces cerevisiae protein that particip... | https://www.wikidoc.org/index.php/MSH5 | |
949e4076978f67f47d55e67a9f3d211a0d5c8b36 | wikidoc | MSH6 | MSH6
MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. It is the homologue of the human "G/T binding protein," (GTBP) also called p160 or hMSH6 (human MSH6). The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are inv... | MSH6
MSH6 or mutS homolog 6 is a gene that codes for DNA mismatch repair protein Msh6 in the budding yeast Saccharomyces cerevisiae. It is the homologue of the human "G/T binding protein," (GTBP) also called p160 or hMSH6 (human MSH6). The MSH6 protein is a member of the Mutator S (MutS) family of proteins that are in... | https://www.wikidoc.org/index.php/MSH6 | |
a88b938351c4c0b7fd70dc4c70c4e39f272b0a41 | wikidoc | MSI1 | MSI1
RNA-binding protein Musashi homolog 1 also known as Musashi-1 is a protein that in humans is encoded by the MSI1 gene.
# Function
This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA binding protein that is involved in post-transcriptional gene editing. It is... | MSI1
RNA-binding protein Musashi homolog 1 also known as Musashi-1 is a protein that in humans is encoded by the MSI1 gene.[1][2]
# Function
This gene encodes a protein containing two conserved tandem RNA recognition motifs and functions as an RNA binding protein that is involved in post-transcriptional gene editing.... | https://www.wikidoc.org/index.php/MSI1 | |
7dda57e930a55e46c111770c5ae8698825ce839c | wikidoc | MSMB | MSMB
Beta-microseminoprotein is a protein that in humans is encoded by the MSMB gene. For historical reasons, the scientific literature may also refer to this protein as Prostate secretory protein 94 (PSP94), microseminoprotein (MSP), microseminoprotein-beta (MSMB), beta-inhibitin, prostatic inhibin peptide (PIP), and ... | MSMB
Beta-microseminoprotein is a protein that in humans is encoded by the MSMB gene.[1][2] For historical reasons, the scientific literature may also refer to this protein as Prostate secretory protein 94 (PSP94), microseminoprotein (MSP), microseminoprotein-beta (MSMB), beta-inhibitin, prostatic inhibin peptide (PIP... | https://www.wikidoc.org/index.php/MSMB | |
66d19f58ae901ba8a7341096cc48802960fc0e84 | wikidoc | MSR1 | MSR1
Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene.
MSR1 has also recently been designated CD204 (cluster of differentiation 204).
# Function
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) gener... | MSR1
Macrophage scavenger receptor 1, also known as MSR1, is a protein which in humans is encoded by the MSR1 gene.[1][2]
MSR1 has also recently been designated CD204 (cluster of differentiation 204).
# Function
This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3... | https://www.wikidoc.org/index.php/MSR1 | |
46e17f125d464fc761862f7f384387d6ac2eac40 | wikidoc | MSX1 | MSX1
Msh homeobox 1, also known as MSX1, is a protein that in humans is encoded by the MSX1 gene. MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is responsive to ... | MSX1
Msh homeobox 1, also known as MSX1, is a protein that in humans is encoded by the MSX1 gene.[1][2] MSX1 transcripts are not only found in thyrotrope-derived TSH cells, but also in the TtT97 thyrotropic tumor, which is a well differentiated hyperplastic tissue that produces both TSHß- and a-subunits and is respons... | https://www.wikidoc.org/index.php/MSX1 | |
b91524954d4393e9452e4918f3bb840428609f65 | wikidoc | MTA1 | MTA1
Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. MTA1 is the founding member of the MTA family of genes. MTA1 is primarily localized in the nucleus but also found to be distributed in the extra-nuclear compartments. MTA1 is a component of several chromatin remodeling com... | MTA1
Metastasis-associated protein MTA1 is a protein that in humans is encoded by the MTA1 gene. MTA1 is the founding member of the MTA family of genes.[1][2] MTA1 is primarily localized in the nucleus but also found to be distributed in the extra-nuclear compartments.[3][4] MTA1 is a component of several chromatin r... | https://www.wikidoc.org/index.php/MTA1 | |
1254008c1fd91afa52c9dc990177a4018929691b | wikidoc | MTA2 | MTA2
Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.
MTA2 is the second member of the MTA family of genes. MTA2 protein localizes in the nucleus and is a component of the nucleosome remodeling and the deacetylation complex (NuRD). Similar to the founding family member MTA1, ... | MTA2
Metastasis-associated protein MTA2 is a protein that in humans is encoded by the MTA2 gene.[1][2]
MTA2 is the second member of the MTA family of genes.[1][3][4] MTA2 protein localizes in the nucleus and is a component of the nucleosome remodeling and the deacetylation complex (NuRD).[4] Similar to the founding f... | https://www.wikidoc.org/index.php/MTA2 | |
95000247884ff18ecca0a9d3974b7a07b3ee31d5 | wikidoc | MTA3 | MTA3
Metastasis-associated protein MTA3 is a protein that in humans is encoded by the MTA3 gene. MTA3 protein localizes in the nucleus as well as in other cellular compartments MTA3 is a component of the nucleosome remodeling and deacetylate (NuRD) complex and participates in gene expression. The expression pattern of ... | MTA3
Metastasis-associated protein MTA3 is a protein that in humans is encoded by the MTA3 gene.[1][2][3][4] MTA3 protein localizes in the nucleus as well as in other cellular compartments[5] MTA3 is a component of the nucleosome remodeling and deacetylate (NuRD) complex and participates in gene expression.[6][7][8] T... | https://www.wikidoc.org/index.php/MTA3 | |
73bcaf74ddf4bd5abd49e7ee65ad04c29ee4e886 | wikidoc | MTDH | MTDH
Metadherin, also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene.
# Function
AEG-1 is involved in HIF-1alpha mediated angiogenesis. AEG-1 also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays very importa... | MTDH
Metadherin, also known as protein LYRIC or astrocyte elevated gene-1 protein (AEG-1) is a protein that in humans is encoded by the MTDH gene.[1][2][3]
# Function
AEG-1 is involved in HIF-1alpha mediated angiogenesis. AEG-1 also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays ve... | https://www.wikidoc.org/index.php/MTDH | |
24ed1b38d68256d70a821120446542a4624c9d56 | wikidoc | mTOR | mTOR
The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene. mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein kinases.
m... | mTOR
The mammalian target of rapamycin (mTOR), also known as the mechanistic target of rapamycin and FK506-binding protein 12-rapamycin-associated protein 1 (FRAP1), is a kinase that in humans is encoded by the MTOR gene.[1][2][3] mTOR is a member of the phosphatidylinositol 3-kinase-related kinase family of protein ... | https://www.wikidoc.org/index.php/MTOR | |
5193008feb20cb2b46b705cc67c973d4f5a37221 | wikidoc | MUC1 | MUC1
Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans. MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and seve... | MUC1
Mucin 1, cell surface associated (MUC1) or polymorphic epithelial mucin (PEM) is a mucin encoded by the MUC1 gene in humans.[1] MUC1 is a glycoprotein with extensive O-linked glycosylation of its extracellular domain. Mucins line the apical surface of epithelial cells in the lungs, stomach, intestines, eyes and ... | https://www.wikidoc.org/index.php/MUC1 | |
113bb7bade2f5af0cb51379f0dc4bafcab1dbd1e | wikidoc | MUL1 | MUL1
Mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1. This enzyme localizes to the outer mitochondrial membrane, where it regulates mitochondrial morphology and apoptosis through multiple pathways, including the Akt, JNK, and NF-κB. Its proapopo... | MUL1
Mitochondrial E3 ubiquitin protein ligase 1 (MUL1) is an enzyme that in humans is encoded by the MUL1 gene on chromosome 1. This enzyme localizes to the outer mitochondrial membrane, where it regulates mitochondrial morphology and apoptosis through multiple pathways, including the Akt, JNK, and NF-κB.[1][2][3] It... | https://www.wikidoc.org/index.php/MUL1 | |
f925f798ccd8e38c16d83917dda54ce1ff972fb2 | wikidoc | MXD1 | MXD1
MAD protein is a protein that in humans is encoded by the MXD1 gene.
MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to function... | MXD1
MAD protein is a protein that in humans is encoded by the MXD1 gene.[1][2]
MAD-MAX dimerization protein belongs to a subfamily of MAX-interacting proteins. This protein competes with MYC for binding to MAX to form a sequence-specific DNA-binding complex, acts as a transcriptional repressor (while MYC appears to f... | https://www.wikidoc.org/index.php/MXD1 | |
18f2d4bd220db04f8a4fa5a19bc419af0bc2c57c | wikidoc | MYF5 | MYF5
Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene.
It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop he... | MYF5
Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene.
[1]
It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix lo... | https://www.wikidoc.org/index.php/MYF5 | |
ab796efe30c45823314cdd36e3a1ec148b4600c9 | wikidoc | MYF6 | MYF6
Myogenic factor 6 (herculin) is a protein that in humans is encoded by the MYF6 gene.
Also known in the medical literature as MRF4 and herculin), MYF6 is a myogenic regulatory factor (MRF) in the process known as myogenesis.
# Function
MYF6 is a member of the myogenic factors (MYF) family that regulate myogenesis... | MYF6
Myogenic factor 6 (herculin) is a protein that in humans is encoded by the MYF6 gene.
[1]
Also known in the medical literature as MRF4 and herculin), MYF6 is a myogenic regulatory factor (MRF) in the process known as myogenesis.[2][3]
# Function
MYF6 is a member of the myogenic factors (MYF) family that regulate... | https://www.wikidoc.org/index.php/MYF6 | |
7e7eb9564bd9b8d350145abf5a298130249edb5d | wikidoc | MYH6 | MYH6
Myosin heavy chain, α isoform (MHC-α) is a protein that in humans is encoded by the MYH6 gene. This isoform is distinct from the ventricular/slow myosin heavy chain isoform, MYH7, referred to as MHC-β. MHC-α isoform is expressed predominantly in human cardiac atria, exhibiting only minor expression in human cardia... | MYH6
Myosin heavy chain, α isoform (MHC-α) is a protein that in humans is encoded by the MYH6 gene.[1][2] This isoform is distinct from the ventricular/slow myosin heavy chain isoform, MYH7, referred to as MHC-β. MHC-α isoform is expressed predominantly in human cardiac atria, exhibiting only minor expression in human... | https://www.wikidoc.org/index.php/MYH6 | |
7c28b219988c186297871cea1cee700321095677 | wikidoc | MYH7 | MYH7
MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in skeletal muscles (type I fibers). This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. MHC-β is the major protein comprising the thick f... | MYH7
MYH7 is a gene encoding a myosin heavy chain beta (MHC-β) isoform (slow twitch) expressed primarily in the heart, but also in skeletal muscles (type I fibers).[1] This isoform is distinct from the fast isoform of cardiac myosin heavy chain, MYH6, referred to as MHC-α. MHC-β is the major protein comprising the thi... | https://www.wikidoc.org/index.php/MYH7 | |
64431ba98097b836822502a9d4aada54b1d5054b | wikidoc | MYH9 | MYH9
Myosin-9 also known as myosin, heavy chain 9, non-muscle or non-muscle myosin heavy chain IIa (NMMHC-IIA) is a protein which in humans is encoded by the MYH9 gene.
Non-muscle myosin IIA (NM IIA) is expressed in most cells and tissues where it participates in a variety of processes requiring contractile force, such... | MYH9
Myosin-9 also known as myosin, heavy chain 9, non-muscle or non-muscle myosin heavy chain IIa (NMMHC-IIA) is a protein which in humans is encoded by the MYH9 gene.[1][2]
Non-muscle myosin IIA (NM IIA) is expressed in most cells and tissues where it participates in a variety of processes requiring contractile forc... | https://www.wikidoc.org/index.php/MYH9 | |
21b7a70ab79a1601d0edac838b2be3eb70da086a | wikidoc | MYL2 | MYL2
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene. This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle (MYLPF), smooth muscle (MYL12B) and c... | MYL2
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform (MLC-2) also known as the regulatory light chain of myosin (RLC) is a protein that in humans is encoded by the MYL2 gene.[1][2] This cardiac ventricular RLC isoform is distinct from that expressed in skeletal muscle (MYLPF), smooth muscle (MYL12B... | https://www.wikidoc.org/index.php/MYL2 | |
ad5b2a58cabd0575d4f39b16e6ca3dd1a7e61927 | wikidoc | MYL3 | MYL3
Myosin essential light chain (ELC), ventricular/cardiac isoform is a protein that in humans is encoded by the MYL3 gene. This cardiac ventricular/slow skeletal ELC isoform is distinct from that expressed in fast skeletal muscle (MYL1) and cardiac atrial muscle (MYL4). Ventricular ELC is part of the myosin molecule... | MYL3
Myosin essential light chain (ELC), ventricular/cardiac isoform is a protein that in humans is encoded by the MYL3 gene.[1][2][3] This cardiac ventricular/slow skeletal ELC isoform is distinct from that expressed in fast skeletal muscle (MYL1) and cardiac atrial muscle (MYL4). Ventricular ELC is part of the myosi... | https://www.wikidoc.org/index.php/MYL3 | |
9b064745a28603c714893511eedc0187e2798325 | wikidoc | MYL4 | MYL4
Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene. ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular myocar... | MYL4
Atrial Light Chain-1 (ALC-1), also known as Essential Light Chain, Atrial is a protein that in humans is encoded by the MYL4 gene.[1][2] ALC-1 is expressed in fetal cardiac ventricular and fetal skeletal muscle, as well as fetal and adult cardiac atrial tissue. ALC-1 expression is reactivated in human ventricular... | https://www.wikidoc.org/index.php/MYL4 | |
8ecb28300bb44263b19c5f63b36dec1cfb2492f6 | wikidoc | MYL7 | MYL7
Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans is encoded by the MYL7 gene. ALC-2 expression is restricted to cardiac muscle atria in healthy individuals, where it functions to modulate cardiac development and contractility. In human d... | MYL7
Atrial Light Chain-2 (ALC-2) also known as Myosin regulatory light chain 2, atrial isoform (MLC2a) is a protein that in humans is encoded by the MYL7 gene.[1][2] ALC-2 expression is restricted to cardiac muscle atria in healthy individuals, where it functions to modulate cardiac development and contractility. In ... | https://www.wikidoc.org/index.php/MYL7 | |
9e579eaf1f9109eb9c156e1ec7c66e24718f09e5 | wikidoc | MYOT | MYOT
Myotilin is a protein that in humans is encoded by the MYOT gene. Myotilin (myofibrillar titin-like protein) also known as TTID (TiTin Immunoglobulin Domain) is a muscle protein that is found within the Z-disc of sarcomeres.
# Structure
Myotilin is a 55.3 kDa protein composed of 496 amino acids. Myotilin was orig... | MYOT
Myotilin is a protein that in humans is encoded by the MYOT gene.[1][2][3] Myotilin (myofibrillar titin-like protein) also known as TTID (TiTin Immunoglobulin Domain) is a muscle protein that is found within the Z-disc of sarcomeres.
# Structure
Myotilin is a 55.3 kDa protein composed of 496 amino acids.[4] Myot... | https://www.wikidoc.org/index.php/MYOT | |
b3ea4867c99ab1ea3622607f339ad8d7e0310c55 | wikidoc | MYPN | MYPN
Myopalladin is a protein that in humans is encoded by the MYPN gene. Myopalladin is a muscle protein responsible for tethering proteins at the Z-disc and for communicating between the sarcomere and the nucleus in cardiac and skeletal muscle
# Structure
Myopalladin is a 145.2 kDa protein composed of 1320 amino aci... | MYPN
Myopalladin is a protein that in humans is encoded by the MYPN gene. Myopalladin is a muscle protein responsible for tethering proteins at the Z-disc and for communicating between the sarcomere and the nucleus in cardiac and skeletal muscle[1][2][3]
# Structure
Myopalladin is a 145.2 kDa protein composed of 1320... | https://www.wikidoc.org/index.php/MYPN | |
2d710737be9db686849b5162cc5c864912abfe79 | wikidoc | MYT1 | MYT1
Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.
# Function
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central nervous syste... | MYT1
Myelin transcription factor 1 is a protein that in humans is encoded by the MYT1 gene.[1][2][3]
# Function
The protein encoded by this gene is a member of a family of neural specific, zinc finger-containing DNA-binding proteins. The protein binds to the promoter regions of proteolipid proteins of the central ner... | https://www.wikidoc.org/index.php/MYT1 | |
a75264a42edc11f7d505330ba334458cdb8cbdc6 | wikidoc | Male | Male
# Overview
Male (♂) refers to the sex of an organism, or part of an organism, which produces small mobile gametes, called spermatozoa. Each spermatozoon can fuse with a larger female gamete or ovum, in the process of fertilisation. A male cannot reproduce sexually without access to at least one ovum from a female... | Male
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
# Overview
Male (♂) refers to the sex of an organism, or part of an organism, which produces small mobile gametes, called spermatozoa. Each spermatozoon can fuse with a larger female gamete or ovum, in the process of fertilisation. A male cannot reproduce sexual... | https://www.wikidoc.org/index.php/Male | |
07a018722a76254aedb9130939399d7211e93eb6 | wikidoc | Mass | Mass
Mass is a fundamental concept in physics, roughly corresponding to the intuitive idea of "how much matter there is in an object". Mass is a central concept of classical mechanics and related subjects, and there are several definitions of mass within the framework of relativistic kinematics (see mass in special rel... | Mass
Template:Tfd
Mass is a fundamental concept in physics, roughly corresponding to the intuitive idea of "how much matter there is in an object". Mass is a central concept of classical mechanics and related subjects, and there are several definitions of mass within the framework of relativistic kinematics (see mass ... | https://www.wikidoc.org/index.php/Mass | |
b0f7085318f828b27cff5296d2680e71b633002c | wikidoc | Mdm2 | Mdm2
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation do... | Mdm2
Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene.[1][2] Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activa... | https://www.wikidoc.org/index.php/Mdm2 |
Subsets and Splits
Medical Guidelines Search Results
Identifies and retrieves distinct research paper titles related to various medical and psychological conditions, revealing the scope and focus areas within the dataset that might be relevant for understanding disease prevalence or research interest patterns.
SQL Console for epfl-llm/guidelines
This query extracts and contextualizes date patterns from text data, revealing temporal information embedded within documents which can help identify time-related trends and patterns in the content.
Count and Percentage of 'None'
The query reveals the frequency of 'none' values in raw and clean text fields, their percentage in the dataset, and average text length differences, providing valuable insights for data cleaning and quality assessment.
Unique titles stigmatized conditions
Filters and retrieves distinct article titles containing various mental health, behavioral, and chronic condition related terms to identify research topics in psychology and medicine.
ME/CFS, Obesity, SUD, ED Studies
Retrieves distinct article titles containing keywords related to specific medical conditions, providing a useful starting point for exploring research topics in chronic fatigue, obesity, substance use, and eating disorders.
Guidelines with Date Context Extraction
Extracts text snippets containing month names to identify temporal references, which could help in understanding time-related patterns in the training data.
SQL Console for epfl-llm/guidelines
Identifies records containing frequent occurrences of mental health keywords, providing basic filtering for text analysis but offering limited insight beyond keyword frequency counting.
Top Texts with Bisplar Disorder
Identifies texts with high frequency of "bipolar disorder" mentions, useful for understanding how often this term appears in the dataset but doesn't reveal deeper patterns or relationships.
Peptic Ulcer and H. Pylori
Retrieves distinct article titles containing specific medical terms related to digestive disorders and mental health conditions, providing basic filtering of relevant literature but offering limited analytical value beyond simple keyword matching.
Filter Bipolar, Depression Mentions
Filters for records containing the terms "bipolar_disorder" or "depression" at least 5 times each, but doesn't provide meaningful analysis beyond basic keyword frequency counting.
Bipolar Disorder Training Data
Performs basic filtering to find records containing "bipolar disorder" in the clean_text field, which is useful for initial topic exploration but doesn't provide deeper analytical insights.
PubMed Guidelines Sample
Retrieves 100 samples from the 'train' dataset where the source is 'pubmed', providing a basic view of the data but limited analytical value.
Text Length Statistics
Provides the minimum and maximum lengths of both cleaned and raw text, offering basic insights into text length variation.
Count None Values in Text Columns
Counts the occurrences and percentages of rows where 'raw_text' or 'clean_text' is 'none', providing a basic overview of missing or placeholder data.
Top 100 Longest Clean Texts
Retrieves the 100 longest cleaned text entries along with their raw text versions, offering basic insight into text length differences.
Longest Clean Text Entries
Returns the 100 longest clean texts in the dataset, which could help identify unusually long entries for quality review.
Longest Clean Text Entries
Returns the 100 longest cleaned text entries by id and title, providing basic information about the longest entries without significant analytical insight.