Datasets:

everycure
/

matrix-scores

source string	target string	source_ec_id string	is_known_positive bool	is_known_negative bool	trial_sig_better bool	trial_non_sig_better bool	trial_sig_worse bool	trial_non_sig_worse bool	off_label bool	ec_indications_list_off_label bool	ec_indications_list_on_label bool	ec_indications_list bool	not treat score float64	untransformed_treat_score float64	unknown score float64	untransformed_rank int64	quantile_rank float64	rank_drug int32	quantile_drug float64	rank_disease int32	quantile_disease float64	transformed_treat_score float64	rank int32	y int32
CHEBI:28304	MONDO:0003307	EC:00780	false	false	false	false	false	false	false	false	false	false	0.000029	0.000795	0.999177	5,769,882	0.193166	393	0.224828	6,100	0.270139	3.245988	7,619,351	null
CHEBI:8357	MONDO:0011403	EC:01328	false	false	false	false	false	false	false	false	false	false	0.001731	0.000627	0.997642	6,292,681	0.194127	253	0.144737	8,886	0.393517	3.245321	7,657,262	null
CHEBI:50122	MONDO:0100521	EC:01440	false	false	false	false	false	false	false	false	false	false	0.000019	0.000001	0.999981	29,824,940	0.501059	280	0.160183	19,302	0.854789	3.117847	19,764,097	null
CHEBI:76128	MONDO:0017907	EC:00481	false	false	false	false	false	false	false	false	false	false	0	0	1	31,129,330	0.515988	306	0.175057	18,190	0.805544	3.113819	20,352,967	null
CHEBI:45863	MONDO:0800310	EC:01218	false	false	false	false	false	false	false	false	false	false	0.000615	0.000644	0.99874	6,230,213	0.203117	228	0.130435	11,273	0.499225	3.239222	8,011,864	null
CHEBI:50378	MONDO:0800101	EC:01147	false	false	false	false	false	false	false	false	false	false	0.00072	0.000188	0.999092	9,438,158	0.197258	364	0.208238	4,225	0.187104	3.243155	7,780,776	null
PUBCHEM.COMPOUND:11979316	MONDO:0100156	EC:01726	false	false	false	false	false	false	false	false	false	false	0.000122	0.000547	0.999331	6,608,473	0.196964	511	0.292334	4,297	0.190293	3.243359	7,769,174	null
CHEBI:81567	MONDO:0011165	EC:01621	false	false	false	false	false	false	false	false	false	false	0.000059	0.000048	0.999893	13,825,219	0.517363	1,209	0.691648	10,104	0.447456	3.113452	20,407,221	null
CHEBI:62984	MONDO:0019120	EC:01779	false	false	false	false	false	false	false	false	false	false	0.000002	0.000086	0.999911	11,866,520	0.201238	98	0.056064	14,157	0.626943	3.240476	7,937,774	null
CHEBI:107736	MONDO:0003412	EC:01037	false	false	false	false	false	false	false	false	false	false	0.00018	0.000364	0.999455	7,607,779	0.182704	177	0.101259	9,111	0.403481	3.25351	7,206,696	null
CHEBI:50885	MONDO:0030700	EC:00694	false	false	false	false	false	false	false	false	false	false	0.000016	0.000255	0.999728	8,555,777	0.200855	175	0.100114	10,432	0.461981	3.240731	7,922,670	null
CHEBI:116735	MONDO:0003034	EC:00180	false	false	false	false	false	false	false	false	false	false	0.000019	0.000008	0.999973	20,435,824	0.514683	612	0.350114	13,289	0.588504	3.114166	20,301,501	null
CHEBI:7907	MONDO:0019249	EC:01230	false	false	false	false	false	false	false	false	false	false	0.000853	0.000022	0.999125	16,680,927	0.519256	1,451	0.830092	7,091	0.314025	3.112949	20,481,883	null
CHEBI:29013	MONDO:0017682	EC:00730	false	false	false	false	false	false	false	false	false	false	0	0.000001	0.999999	27,143,893	0.200241	36	0.020595	19,249	0.852442	3.241138	7,898,420	null
CHEBI:3216	MONDO:0010347	EC:00241	false	false	false	false	false	false	false	false	false	false	0.000052	0.000013	0.999935	18,683,614	0.515814	729	0.417048	12,239	0.542004	3.113865	20,346,082	null
CHEBI:8412	MONDO:0005212	EC:01342	false	false	false	false	false	false	false	false	false	false	0.000004	0.000112	0.999883	11,001,317	0.503057	1,042	0.59611	13,734	0.60821	3.117304	19,842,921	null
CHEBI:18385	MONDO:0010692	EC:01613	false	false	false	false	false	false	false	false	false	false	0.000144	0.000005	0.999851	22,096,668	0.500931	437	0.25	16,210	0.71786	3.117883	19,759,060	null
CHEBI:71219	MONDO:0010505	EC:01243	false	false	false	false	false	false	false	false	false	false	0.000003	0.00001	0.999986	19,495,186	0.515676	605	0.34611	14,175	0.62774	3.113902	20,340,643	null
CHEBI:5004	MONDO:0009621	EC:00669	false	false	false	false	false	false	false	false	false	false	0	0	1	32,764,879	0.514777	262	0.149886	20,324	0.900049	3.114142	20,305,186	null
CHEBI:63635	MONDO:0001186	EC:01715	false	false	false	false	false	false	false	false	false	false	0.000004	0.000027	0.999969	15,892,973	0.499689	1,010	0.577803	9,559	0.42332	3.118224	19,710,047	null
CHEBI:31759	MONDO:0009672	EC:01795	false	false	false	false	false	false	false	false	false	false	0.000003	0.000121	0.999876	10,764,460	0.194661	1,432	0.819222	1,014	0.044905	3.244952	7,678,322	null
CHEBI:85662	MONDO:0001030	EC:00939	false	false	false	false	false	false	false	false	false	false	0	0.000015	0.999985	18,111,328	0.516259	1,012	0.578947	9,123	0.404012	3.113747	20,363,638	null
UNII:70BSQ12069	MONDO:0020369	EC:00963	false	false	false	false	false	false	false	false	false	false	0.000016	0.000196	0.999788	9,305,656	0.205044	1,337	0.764874	1,390	0.061556	3.23795	8,087,886	null
UNII:15C2VL427D	MONDO:0018975	EC:00032	false	false	false	false	false	false	false	false	false	false	0	0.000067	0.999933	12,710,210	0.22002	124	0.070938	12,810	0.567291	3.228456	8,678,595	null
UNII:UYB6UOF69L	MONDO:0957254	EC:00984	false	false	false	false	false	false	false	false	false	false	0.000001	0.000131	0.999868	10,513,010	0.210479	792	0.453089	2,115	0.093663	3.234423	8,302,257	null
CHEBI:183811	MONDO:0010405	EC:01086	false	false	false	false	false	false	false	false	false	false	0.000024	0.000013	0.999963	18,587,099	0.518445	1,385	0.792334	6,639	0.294008	3.113164	20,449,864	null
CHEBI:3766	MONDO:0005995	EC:00379	false	false	false	false	false	false	false	false	false	false	0.01321	0.000616	0.986174	6,334,067	0.218558	284	0.162471	10,613	0.469997	3.229351	8,620,945	null
CHEBI:78543	MONDO:0043771	EC:01312	false	false	false	false	false	false	false	false	false	false	0	0.00039	0.999609	7,432,386	0.196123	539	0.308352	3,590	0.158983	3.243932	7,736,000	null
CHEBI:291342	MONDO:0030770	EC:00468	false	false	false	false	false	false	false	false	false	false	0.000006	0.000144	0.99985	10,232,232	0.215259	163	0.093249	11,207	0.496302	3.231391	8,490,818	null
CHEBI:27834	MONDO:0858957	EC:01261	false	false	false	false	false	false	false	false	false	false	0.000172	0.000116	0.999712	10,897,420	0.192624	113	0.064645	11,756	0.520615	3.246369	7,598,000	null
UNII:L1F3R18W77	MONDO:0003098	EC:00114	false	false	false	false	false	false	false	false	false	false	0.000001	0.000213	0.999786	9,070,315	0.202681	904	0.517162	1,969	0.087197	3.239513	7,994,661	null
CHEBI:31159	MONDO:0015048	EC:00011	false	false	false	false	false	false	false	false	false	false	0	0.000007	0.999993	20,906,119	0.514952	498	0.284897	16,103	0.713122	3.114095	20,312,093	null
CHEBI:29105	MONDO:0020466	EC:01730	false	false	false	false	false	false	false	false	false	false	0.000005	0.000126	0.999869	10,632,672	0.217389	1,378	0.78833	1,371	0.060715	3.230071	8,574,837	null
DRUGBANK:DB16802	MONDO:0013510	EC:00459	false	false	false	false	false	false	false	false	false	false	0.000001	0.000005	0.999993	21,957,650	0.517918	1,038	0.593822	7,426	0.328861	3.113305	20,429,082	null
CHEBI:4822	MONDO:0004922	EC:00614	false	false	false	false	false	false	false	false	false	false	0.000001	0.00028	0.999719	8,302,078	0.21356	505	0.288902	4,228	0.187237	3.232465	8,423,805	null
CHEBI:230846	MONDO:0013818	EC:01248	false	false	false	false	false	false	false	false	false	false	0.000002	0.00009	0.999907	11,706,232	0.216342	612	0.350114	2,596	0.114964	3.23072	8,533,524	null
CHEBI:135809	MONDO:0008962	EC:00879	false	false	false	false	false	false	false	false	false	false	0	0.000014	0.999986	18,292,229	0.500917	964	0.551487	8,755	0.387715	3.117887	19,758,492	null
CHEBI:724125	MONDO:0006841	EC:01029	false	false	false	false	false	false	false	false	false	false	0.000012	0.000176	0.999812	9,624,807	0.221168	796	0.455378	2,580	0.114255	3.227756	8,723,879	null
CHEBI:6413	MONDO:0002078	EC:00902	false	false	false	false	false	false	false	false	false	false	0.001072	0.000764	0.998164	5,855,120	0.183035	687	0.393021	3,044	0.134804	3.253266	7,219,762	null
CHEBI:135923	MONDO:0005559	EC:01053	false	false	false	false	false	false	false	false	false	false	0.000005	0.000128	0.999867	10,582,107	0.212934	1,532	0.87643	1,196	0.052965	3.232861	8,399,107	null
CHEBI:8066	MONDO:0014938	EC:01273	false	false	false	false	false	false	false	false	false	false	0.000021	0.000135	0.999844	10,429,185	0.218456	941	0.53833	1,988	0.088039	3.229413	8,616,905	null
CHEBI:63916	MONDO:0017019	EC:00814	false	false	false	false	false	false	false	false	false	false	0	0.000159	0.999841	9,922,284	0.197861	255	0.145881	5,806	0.257119	3.242745	7,804,576	null
CHEBI:599440	MONDO:0005193	EC:00079	false	false	false	false	false	false	false	false	false	false	0.000001	0.000271	0.999729	8,398,244	0.220028	983	0.562357	2,390	0.105841	3.228451	8,678,923	null
CHEBI:4031	MONDO:0008673	EC:00414	false	false	false	false	false	false	false	false	false	false	0.000001	0.000084	0.999916	11,950,196	0.207834	104	0.059497	14,310	0.633719	3.236126	8,197,937	null
CHEBI:3698	MONDO:0018015	EC:00341	false	false	false	false	false	false	false	false	false	false	0	0.000002	0.999998	25,683,578	0.515236	1,520	0.869565	4,391	0.194456	3.11402	20,323,300	null
CHEBI:3696	MONDO:0007762	EC:00340	false	false	false	false	false	false	false	false	false	false	0.000021	0.000781	0.999198	5,807,813	0.20765	764	0.437071	3,781	0.167442	3.236243	8,190,666	null
CHEBI:3478	MONDO:0859339	EC:00291	false	false	false	false	false	false	false	false	false	false	0	0	1	31,786,319	0.516014	278	0.159039	19,769	0.875471	3.113812	20,354,000	null
CHEBI:6339	MONDO:0005888	EC:00647	false	false	false	false	false	false	false	false	false	false	0.000003	0.000367	0.99963	7,592,979	0.21875	783	0.447941	3,214	0.142332	3.229233	8,628,526	null
UNII:P0GVQ9A4S5	MONDO:0006629	EC:00533	false	false	false	false	false	false	false	false	false	false	0	0.000182	0.999818	9,520,717	0.207055	1,526	0.872998	1,240	0.054913	3.236627	8,167,223	null
CHEBI:40279	MONDO:0006118	EC:00049	false	false	false	false	false	false	false	false	false	false	0.000033	0.001007	0.99896	5,279,434	0.198246	341	0.19508	8,263	0.365927	3.242483	7,819,759	null
UMLS:C5557539	MONDO:0011014	EC:01225	false	false	false	false	false	false	false	false	false	false	0	0.000005	0.999995	22,366,399	0.507048	1,602	0.916476	4,577	0.202693	3.116218	20,000,333	null
UNII:YI437801BE	MONDO:0006774	EC:01076	false	false	false	false	false	false	false	false	false	false	0	0.000376	0.999624	7,530,730	0.19051	1,195	0.683638	1,577	0.069837	3.247858	7,514,607	null
CHEBI:90908	MONDO:0008599	EC:01434	false	false	false	false	false	false	false	false	false	false	0	0.000077	0.999923	12,257,310	0.190608	1,620	0.926773	773	0.034232	3.247789	7,518,456	null
CHEBI:63630	MONDO:0011739	EC:01650	false	false	false	false	false	false	false	false	false	false	0.000046	0.00001	0.999944	19,607,319	0.518026	540	0.308924	16,050	0.710775	3.113276	20,433,364	null
CHEBI:4798	MONDO:0100403	EC:00594	false	false	false	false	false	false	false	false	false	false	0.00001	0.000001	0.999989	29,978,754	0.519057	296	0.169336	19,903	0.881405	3.113002	20,474,026	null
CHEBI:16664	MONDO:0859282	EC:00035	false	false	false	false	false	false	false	false	false	false	0.000007	0.001179	0.998814	4,969,258	0.194188	264	0.15103	10,915	0.483371	3.245278	7,659,666	null
CHEBI:71019	MONDO:0001188	EC:01183	false	false	false	false	false	false	false	false	false	false	0	0.000005	0.999995	22,173,520	0.513584	506	0.289474	14,816	0.656127	3.114458	20,258,137	null
CHEBI:140628	MONDO:0012146	EC:01467	false	false	false	false	false	false	false	false	false	false	0.000186	0.000486	0.999328	6,890,464	0.18479	712	0.407323	2,565	0.113591	3.251979	7,288,992	null
UMLS:C0032140	MONDO:0008102	EC:01302	false	false	false	false	false	false	false	false	false	false	0.000394	0.000331	0.999275	7,854,942	0.19604	445	0.254577	4,092	0.181214	3.243991	7,732,736	null
CHEBI:50859	MONDO:0003588	EC:00200	false	false	false	false	false	false	false	false	false	false	0.000001	0.00006	0.999939	13,100,092	0.200702	152	0.086957	7,845	0.347416	3.240831	7,916,603	null
CHEBI:3398	MONDO:0010945	EC:00278	false	false	false	false	false	false	false	false	false	false	0.000581	0.000418	0.999001	7,258,784	0.188987	372	0.212815	4,828	0.213808	3.248944	7,454,523	null
CHEBI:49960	MONDO:0021187	EC:01722	false	false	false	false	false	false	false	false	false	false	0.717472	0.000853	0.281675	5,618,742	0.204777	939	0.537185	3,109	0.137682	3.238124	8,077,373	null
CHEBI:16382	MONDO:0014393	EC:00840	false	false	false	false	false	false	false	false	false	false	0	0.000006	0.999994	21,477,066	0.500513	706	0.40389	10,156	0.449759	3.117997	19,742,560	null
CHEBI:64733	MONDO:0015516	EC:01318	false	false	false	false	false	false	false	false	false	false	0	0	1	37,118,665	0.516618	224	0.128146	21,517	0.952881	3.113651	20,377,817	null
CHEBI:133017	MONDO:0013911	EC:01285	false	false	false	false	false	false	false	false	false	false	0	0.000621	0.999378	6,313,351	0.185419	483	0.276316	4,092	0.181214	3.251519	7,313,791	null
CHEBI:83766	MONDO:0024279	EC:01174	false	false	false	false	false	false	false	false	false	false	0	0.000255	0.999745	8,558,198	0.220739	453	0.259153	4,956	0.219477	3.228017	8,706,958	null
UNII:GK1LYB375A	MONDO:0005753	EC:01663	false	false	false	false	false	false	false	false	false	false	0	0.000157	0.999843	9,975,306	0.196575	960	0.549199	1,585	0.070192	3.243627	7,753,830	null
CHEBI:16664	MONDO:0020796	EC:00035	false	false	false	false	false	false	false	false	false	false	0.000008	0.000684	0.999308	6,096,311	0.193563	193	0.110412	12,172	0.539037	3.245714	7,635,026	null
CHEBI:94563	MONDO:0020088	EC:00184	false	false	false	false	false	false	false	false	false	false	0.00058	0.000243	0.999177	8,692,889	0.187789	1,142	0.653318	1,386	0.061379	3.249803	7,407,264	null
CHEBI:6067	MONDO:0968983	EC:00854	false	false	false	false	false	false	false	false	false	false	0.028637	0.000512	0.970851	6,763,885	0.210685	188	0.107551	14,003	0.620123	3.23429	8,310,400	null
CHEBI:15551	MONDO:0008090	EC:00509	false	false	false	false	false	false	false	false	false	false	0.000401	0.000823	0.998776	5,696,252	0.199856	431	0.246568	6,139	0.271866	3.241394	7,883,232	null
UNII:21904A5386	MONDO:0006304	EC:00893	false	false	false	false	false	false	false	false	false	false	0	0.000001	0.999999	27,123,117	0.505298	340	0.194508	17,619	0.780258	3.116694	19,931,319	null
UNII:G6UF363ECX	MONDO:0010648	EC:00970	false	false	false	false	false	false	false	false	false	false	0.000002	0.000009	0.999989	19,856,705	0.503267	1,323	0.756865	6,023	0.266729	3.117248	19,851,189	null
UMLS:C2350656	MONDO:0004861	EC:01246	false	false	false	false	false	false	false	false	false	false	0	0.00002	0.99998	17,057,597	0.51488	1,150	0.657895	8,486	0.375803	3.114114	20,309,255	null
CHEBI:6794	MONDO:0019897	EC:01014	false	false	false	false	false	false	false	false	false	false	0	0.000001	0.999999	28,476,644	0.197882	34	0.019451	19,038	0.843098	3.24273	7,805,384	null
CHEBI:39211	MONDO:0004336	EC:01520	false	false	false	false	false	false	false	false	false	false	0.000001	0.000019	0.99998	17,147,807	0.5152	1,192	0.681922	8,166	0.361631	3.114029	20,321,871	null
CHEBI:8493	MONDO:0019280	EC:01354	false	false	false	false	false	false	false	false	false	false	0.000003	0.000249	0.999747	8,623,522	0.193032	785	0.449085	2,094	0.092733	3.246083	7,614,095	null
CHEBI:4885	MONDO:0005525	EC:00642	false	false	false	false	false	false	false	false	false	false	0.000023	0.000825	0.999152	5,690,840	0.204817	443	0.253432	6,359	0.281608	3.238098	8,078,939	null
CHEBI:167574	MONDO:0004580	EC:01476	false	false	false	false	false	false	false	false	false	false	0.005958	0.000241	0.993801	8,713,989	0.204619	1,307	0.747712	1,501	0.066472	3.23823	8,071,143	null
RXCUI:967089	MONDO:0032596	EC:00797	false	false	false	false	false	false	false	false	false	false	0.000001	0.000009	0.999991	20,182,000	0.516768	813	0.465103	10,203	0.45184	3.113611	20,383,740	null
CHEBI:94449	MONDO:0002174	EC:00764	false	false	false	false	false	false	false	false	false	false	0.009072	0.000999	0.98993	5,295,808	0.186911	485	0.27746	4,970	0.220097	3.250437	7,372,656	null
CHEBI:8207	MONDO:0005729	EC:01284	false	false	false	false	false	false	false	false	false	false	0.001504	0.000719	0.997777	5,986,184	0.205114	388	0.221968	6,925	0.306674	3.237904	8,090,657	null
CHEBI:2675	MONDO:0004397	EC:00080	false	false	false	false	false	false	false	false	false	false	0.004216	0.000255	0.995528	8,555,319	0.210468	694	0.397025	2,917	0.129179	3.23443	8,301,817	null
CHEBI:4717	MONDO:0016175	EC:00542	false	false	false	false	false	false	false	false	false	false	0.066496	0.000717	0.932787	5,994,066	0.203426	409	0.233982	6,420	0.28431	3.239018	8,024,073	null
CHEBI:5818	MONDO:0007509	EC:00795	false	false	false	false	false	false	false	false	false	false	0.00001	0.000267	0.999723	8,435,007	0.19978	257	0.147025	6,953	0.307914	3.241446	7,880,241	null
CHEBI:136051	MONDO:0800027	EC:00968	false	false	false	false	false	false	false	false	false	false	0	0.000482	0.999518	6,909,067	0.218285	540	0.308924	5,026	0.222577	3.229519	8,610,179	null
CHEBI:8871	MONDO:0004239	EC:01425	false	false	false	false	false	false	false	false	false	false	0.000141	0.000054	0.999804	13,423,084	0.502761	748	0.427918	15,603	0.690979	3.117384	19,831,219	null
CHEMBL.COMPOUND:CHEMBL4582651	MONDO:0007809	EC:01325	false	false	false	false	false	false	false	false	false	false	0	0.000008	0.999992	20,585,751	0.500026	1,016	0.581236	7,370	0.326381	3.118132	19,723,339	null
CHEBI:5147	MONDO:0019268	EC:00716	false	false	false	false	false	false	false	false	false	false	0.009286	0.000295	0.990419	8,161,005	0.189447	714	0.408467	2,305	0.102077	3.248613	7,472,671	null
UNII:B72HH48FLU	MONDO:0006081	EC:00829	false	false	false	false	false	false	false	false	false	false	0.000001	0.000288	0.999712	8,231,927	0.211248	255	0.145881	8,286	0.366946	3.233932	8,332,611	null
CHEBI:107736	MONDO:0024282	EC:01037	false	false	false	false	false	false	false	false	false	false	0.000012	0.000005	0.999983	21,985,270	0.519024	450	0.257437	17,389	0.770072	3.113011	20,472,717	null
CHEBI:3175	MONDO:0012581	EC:00228	false	false	false	false	false	false	false	false	false	false	0.000106	0.000007	0.999887	20,921,935	0.505652	443	0.253432	17,323	0.767149	3.116598	19,945,250	null
CHEBI:9130	MONDO:0023601	EC:01484	false	false	false	false	false	false	false	false	false	false	0.000001	0.000014	0.999985	18,459,218	0.510873	1,598	0.914188	5,622	0.24897	3.115187	20,151,223	null
CHEBI:50381	MONDO:0020790	EC:01055	false	false	false	false	false	false	false	false	false	false	0	0.000062	0.999938	12,973,394	0.216699	240	0.1373	5,951	0.26354	3.2305	8,547,628	null
UNII:35A26E427H	MONDO:0020716	EC:01398	false	false	false	false	false	false	false	false	false	false	0.000001	0.000014	0.999985	18,327,273	0.506721	1,581	0.904462	5,600	0.247996	3.116307	19,987,424	null
CHEBI:9757	MONDO:0018369	EC:01699	false	false	false	false	false	false	false	false	false	false	0.000003	0.000387	0.99961	7,452,718	0.219536	334	0.191076	7,653	0.338913	3.228751	8,659,514	null
UNII:4B93MGE4AL	MONDO:0019053	EC:00731	false	false	false	false	false	false	false	false	false	false	0.000001	0.000081	0.999917	12,059,203	0.221884	733	0.419336	2,264	0.100261	3.227328	8,752,119	null
CHEBI:17688	MONDO:0957388	EC:01133	false	false	false	false	false	false	false	false	false	false	0.038005	0.000147	0.961849	10,174,978	0.215682	232	0.132723	7,771	0.344139	3.231128	8,507,483	null
CHEBI:3738	MONDO:0004509	EC:00357	false	false	false	false	false	false	false	false	false	false	0.000839	0.000104	0.999057	11,264,884	0.220392	219	0.125286	7,869	0.348479	3.228231	8,693,266	null
CHEBI:45863	MONDO:0011570	EC:01218	false	false	false	false	false	false	false	false	false	false	0.004324	0.000165	0.995511	9,819,157	0.208023	130	0.074371	13,714	0.607325	3.236004	8,205,384	null

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Dataset Description

This dataset contains the output of the MATRIX pipeline — Every Cure's computational drug repurposing scoring system. It provides ML-generated treatment probability scores for ~39.5 million drug-disease pairs, covering ~1,800 drugs × ~22,000 diseases.

⚠️ Research use only. These scores are the output of a computational research pipeline and do not constitute medical advice, clinical recommendations, or endorsement of any drug for any use. All findings require independent scientific and clinical validation before any clinical application.

Column Definitions

Identifiers

Column	Type	Description
`source`	string	Drug identifier in a standard ontology format (e.g. `CHEBI:28304`, `PUBCHEM:5284616`, `DRUGBANK:DB00945`, `UNII:...`)
`target`	string	Disease identifier in MONDO format (e.g. `MONDO:0003307`)
`source_ec_id`	string	Every Cure internal drug identifier (e.g. `EC:00780`)

Ground Truth Labels

These flags indicate whether a drug-disease pair appears in curated reference datasets used during model training and evaluation.

Column	Type	Description
`y`	int	Training label: `1` = known positive (treats), `0` = known negative (does not treat), `2` = unknown
`is_known_positive`	boolean	`true` if this pair is a confirmed drug-disease treatment association in the training data
`is_known_negative`	boolean	`true` if this pair is a confirmed non-treatment association in the training data
`trial_sig_better`	boolean	`true` if the drug showed statistically significant improvement over control in clinical trials for this disease
`trial_non_sig_better`	boolean	`true` if the drug showed non-significant improvement in clinical trials for this disease
`trial_sig_worse`	boolean	`true` if the drug showed statistically significant worsening in clinical trials for this disease
`trial_non_sig_worse`	boolean	`true` if the drug showed non-significant worsening in clinical trials for this disease
`off_label`	boolean	`true` if this pair is documented as an off-label drug use
`ec_indications_list`	boolean	`true` if the pair appears in the Every Cure indications list (on-label or off-label)
`ec_indications_list_on_label`	boolean	`true` if the pair appears as an on-label indication in the Every Cure indications list
`ec_indications_list_off_label`	boolean	`true` if the pair appears as an off-label indication in the Every Cure indications list

ML Prediction Scores

The model outputs three probability scores that sum to approximately 1.0 for each drug-disease pair.

Column	Type	Description
`untransformed_treat_score`	float	Raw model probability that the drug treats the disease (class 1). Higher = more likely to treat.
`not_treat_score`	float	Raw model probability that the drug does not treat the disease (class 0)
`unknown_score`	float	Raw model probability that the relationship is unknown or uncertain (class 2)
`transformed_treat_score`	float	Final treatment score after combining the raw treatment probability with drug-specific and disease-specific ranking signals (see below)

Rankings

Rankings are computed globally across all ~39.5M pairs. Lower rank = higher predicted treatment probability.

Column	Type	Description
`untransformed_rank`	int	Global rank of the pair by `untransformed_treat_score` (1 = highest raw score)
`quantile_rank`	float	`untransformed_rank` normalized to [0, 1]; values near 0 indicate top-ranked pairs
`rank`	int	Global rank of the pair by `transformed_treat_score` (1 = highest final score)
`rank_drug`	int	Rank of this pair among all diseases for the same drug (1 = top disease for this drug)
`quantile_drug`	float	`rank_drug` normalized to [0, 1]
`rank_disease`	int	Rank of this pair among all drugs for the same disease (1 = top drug for this disease)
`quantile_disease`	float	`rank_disease` normalized to [0, 1]

Score Transformation

The transformed_treat_score combines the raw model output with relative rankings to surface candidates that rank highly both globally and within their drug or disease context:

transformed_treat_score = untransformed_treat_score
                        + drug_weight   × rank_drug^(−decay_drug)
                        + disease_weight × rank_disease^(−decay_disease)

Loading the Dataset

from datasets import load_dataset

ds = load_dataset("everycure/matrix-scores", split="train")
df = ds.to_pandas()

For large-scale use, load as a streaming dataset or use the Parquet files directly:

import polars as pl
df = pl.read_parquet("hf://datasets/everycure/matrix-scores/data/train-*.parquet")

Related Resources

Interactive heatmap explorer
Open source pipeline
Drug list · Disease list · KG nodes · KG edges

Disclaimer

The scores and predictions shown in this tool are the output of a computational research pipeline and are intended for research purposes only. They do not constitute medical advice, clinical recommendations, or endorsement of any drug for any use. Every Cure makes no warranties, express or implied, regarding the accuracy, completeness, or fitness for any particular purpose of the information presented. Drug repurposing opportunities identified here require rigorous independent scientific and clinical validation before any clinical application.

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