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Good news re Morning Style!
The skinny tees are brilliant. I have them in all the colours including the new 4! What I really love about them is that stop trousers etc that are a little loose slipping. They are much more comfortable than wearing a belt! Can we please have more of the dark colours – I love them all but the white ones are pretty unforgiving with nothing else on even if you are slim! But the dark ones are extra good.
Also, more of the vercella vita crop tops. There must be a really strong demand as they always sell out within minutes of going to air, and they are rarely put up before the show ( presumably as they would sell out too quickly!) There are loads of longer vest tops but no crop tops online almost all the time. Doesn’t that say that you need to get more of them!! Especially in the summer.
Linda McCluskey’s scrapbook of memories is forged from oil paint and brush strokes.
Many of the images are familiar — Middle Street, The Worthen, downtown canalways — places you might have passed a thousand times. But when McCluskey reimagines them on canvas, the familiar begins to stir.
Brick and mortar. Cobblestones and canals. All bend, curve, twist and turn. You can almost hear the music. Feel the energy. It’s an invitation to step inside McCluskey’s world, where cityscapes seem to breathe.
Lowell, after all, is where she found inspiration to pick up a paintbrush again at age 40. Her success as a full-time working artist in Paris is proof, she says, that it’s never too late to pursue a dream.
Slogging along the daily grind, McCluskey’s art supplies ended up in boxes in a basement. She carried old photos of her favorite works with her as a reminder from time to time of who she was before becoming a mom, a wife and a cubicle dweller.
Sometimes life holds up a mirror and forces you to take a long hard look. Maybe it was the milestone, but McCluskey recalls her 40th birthday jogging something awake inside her.
And just like that, she put her dreams in action. With her kids Jake and Carly all grown up, she enrolled in college courses at UMass Lowell. Back at school, she travelled to France for a painting workshop and fell in love with her life all over again.
She was the happiest she had been in a long time, then tragedy struck. Her partner of six years, Ed McCabe, was killed in a motorcycle accident in 2001.
“I felt like my life was over,” McCluskey admits.
But in the shadow of her grief, she managed to find a sliver of light.
A close friend told her not to focus on the long and rolling highway. Follow the little paths life offers up instead. With nothing left to lose, McCluskey moved to France in January 2002. She was 44.
Picking up her brushes and paint again, she was reborn. Enter Linda McCluskey, the artist. Paris gave her freedom to rediscover and reinvent herself.
“In Paris, if you say you’re a painter, people don’t ask, ‘what do you really do?’ ” she explains.
In 2004, a move into a 6th floor studio overlooking St. Germaine Boulevard gave her a new perspective. Being a “country girl” born and raised in Chelmsford, she had never lived up so high.
The scenes unfolding on her canvas were well painted but still focused on proper form, until a trip to surrealist painter Salvador Dali’s beloved village of Cadaques in Spain pushed her brush in a whole new direction.
The natural beauty of Cadaques inspired Dali and the way he interpreted that on canvas brought attention to the region. Taking in the breathtaking view from a hillside, McCluskey did a Dali-esque painting of the village and the church melting over the mountains.
“After painting traditional views for so long, this felt like freedom to play and make up the impossible,” she says.
It was the beginning of McCluskey’s imaginative “distortion” pieces, and she gained recognition as a unique artist in Paris and in Lowell.
She returns to Lowell each year for inspiration.
Where Middle and Palmer streets intersect.
She points to her painting of Lowell’s Middle Street, one of her favorite downtown spots.
Today she has her own studio at Paris’ 59 Rivoli — one of the top three visited galleries in France — where she was accepted for a permanent residency. Her advice to others: If you love something do it.
Chances are if you’ve been affected by cybercrime in the past year, you’ve been the victim of a banking trojan. Proofpoint’s latest quarterly threat report notes that over half of all successful email-based attacks were propagated by banking trojans (meanwhile ransomware, once one of the greatest threats to enterprises, came in at a mere .1% of total attacks).
This is no coincidence. Unlike the obtrusiveness of most ransomware attacks, where the attacker makes money by getting the victim to pay for the return of their files, a banking trojan is much more pernicious: infected hosts contribute to identity theft by quietly siphoning off sensitive information and login credentials, all the while using the host’s computing power to mine cryptocurrencies and send out spam emails in the background.
A look at Emotet, one of the most prominent banking trojan from the past 18 months, gives insight into the advanced and destructive nature that these attacks can wreak upon an organization.
Emotet, also known as Geodo, has been around for almost five years and started off primarily self-distributed through attempts at brute-forcing user accounts. Attackers would attempt easily-guessable passwords and those found from compromised sites that were sold or published on the darkweb. Instituting password requirements, password rotation, and password lock outs were enough to thwart most initial Emotet iterations. Recently, however, it has gained and maintained relevance by switching to phishing campaigns that use enticing emails and malicious payloads that resist detection and analysis.
An attack usually starts by a victim receiving an email from either a spoofed sender address or a compromised legitimate account. The email and link/attachment are usually themed as something the user would want to click on due to its urgent (invoices, shipping notifications) or contextual (tax season, holiday season) nature. Recent iterations of these malspam emails have a malicious link or macro-enabled Word document which launch when clicked upon, in turn running a PowerShell script that either downloads or runs an already-downloaded malicious payload.
Emotet is largely resistant to signature-based detection because it is polymorphic, meaning it will change its code in slight but meaningful ways every time it is downloaded. Attackers will routinely change the IP addresses and domains that the links and attachments will reach out to, further evading detection solutions. It can also frustrate analysts looking to study the malware because if it senses that it’s in a virtual machine, it won’t download or execute its payload like it would in a normal environment.
1. A spoofed email attempts to convince a user that their tax return transcript was emailed by the IRS, encouraging them to click on a malicious, macro-enabled Word document which would download the Emotet payload.
Emotet is also modular in nature, meaning attackers are able to customize the payload and specify their malware campaign to fit their particular goals. While it primarily delivers trojans that scrape credentials and mine Monero (a cryptocurrency that obscures the source, amount, and destination of its transaction), it’s able to release a host of other attacks into an organization’s network, including ransomware. Once a system is compromised, however, most variations will look to establish persistence on the machine its currently on and spread to more machines by using captured credentials and send out more malicious emails via the victim’s email accounts.
An organization affected by a banking trojan like Emotet could have their sensitive or proprietary information stolen or altered and could witness a disruption to their productivity, files, and reputation. In some cases the cost for the remediation of an incident caused by Emotet costs upwards of $1 million (according to https://www.us-cert.gov/ncas/alerts/TA18-201A and https://www.infosecurity-magazine.com/news/allentown-struggles-with-1-million/).
Purple Teams: Test yourself and inspect what you expect. Conducting a purple team campaign focused on the TTP’s that the Emotet campaigns use you’ll be able to create a defensive playbook to implement.
Email Defense: Help users discern a malicious email from a legitimate one by enabling DMARC and rules to mark external emails, which let your users know when an email is masquerading as an internal email. Security Risk Advisors encourages organizations to utilize an email defense platform that monitors and quarantines malicious emails at the gateway before a user ever sees that email.
Limit Macro Functionality: If a user clicks on an attachment and opens it, Emotet will attempt to run macros or PowerShell scripts to download payloads and establish persistence. By disabling auto-enabled macros and PowerShell for users that don’t need PowerShell, you limit the ability for an attacker to compromise a user’s endpoint via malicious attachment.
LSA Protection and Credential Guard: An attacker is going to want to escalate their privileges by gaining new credentials, oftentimes succeeding by dumping cleartext or hashed credentials stored in memory or a suspended VM. On Windows machines, you can prevent some of these credential attacks by enabling LSA Protection as well as Credential Guard within Windows 10. Both of these protections look to isolate credential processes that attackers love to exploit. While not bulletproof, both help to mitigate common credential dumping techniques.
Monitor, Alert and Hunt: Emotet will attempt to maintain persistence by creating other services and scheduled tasks that a user would never notice. Utilize built-in Windows functionality or a third-party application to monitor for scheduled task or service creation. Conduct threat hunting exercises on the network looking for previously compromised systems.
Quarantine and Investigate: Do your best to quarantine infected hosts from the rest of your network. Perform an investigation upon how the payload propagated and determine what variant it is. Depending on the variant, a simple restart after removing the malicious files could be enough to re-image the endpoint; others will require more serious changes, like backup restoration and the removal of current registry keys, startup items, or services. Security Risk Advisors recommends an EDR solution that will quarantine devices immediately upon detection of a malware infection.
Determine Blast Radius: Using your initial investigation, identify other hosts with similar activity and perform recovery upon those endpoints as well. Determining the vector of attack and the methods through which the attack propagated could reveal vulnerabilities in your architecture.
Reset Credentials: After devices have been successfully segmented and reimaged, make sure to reset accounts passwords for the hosts and applications that have been compromised. Don’t authenticate to infected systems with domain or shared local administrator credentials, as you could allow an attacker to gain further footholds in your network.
Implement Additional Monitoring: Continue to closely monitor those endpoints and your network as a whole for indicators of compromise gathered from your investigation and quarantining. Block those suspicious IP and domain addresses, hashes, macros, and filepaths that were found to execute during the attack. Seeing these still in your environment will be an indicator that a new infection has occurred or the old infection persists.
Emotet isn’t going away, but that doesn’t mean you have to fear it. By practicing common sense principles regarding email and web use, a phishing campaign can be stopped before a banking trojan reaches your network.
“When I received my diagnoses of thyroid cancer I went into total shock. I just closed down, I did not know how I was going to get through this difficult time, I did not know how the French health care worked and I did not speak French.
I telephoned Cancer Support France and asked so many questions; I was then given an "active listener”.
On our first meeting, we discussed my needs, my fears and concerns. The amount of help that I received was invaluable; my new friend came to see me every week. She attended hospital appointments and translated for me. She arranged all my medical papers and correspondence. She also spoke and supported my family. She allowed me to open up and let out all my emotions, it was handled with great respect and privacy.
I can honestly say that the help that I received was instrumental to my recovery.
We're Brunswick Cushion Company from Brunswick, Maine and we serve the greater Maine and New England area - including your town of Rumford, Maine. Our products are custom marine and home cushions, awnings, outdoor furniture and more.
We start by visiting your boat at Rumford where we'll create a unique full size template of each cushion area. These templates enable our skilled craftsmen to create cushions that fit perfectly and look fantastic. watch our interview by BoatMaine.us.
This specification covers the requirements for hose and hose assemblies (see 6.9) which supply breathing oxygen to aircrews during the operation of high performance aircraft.
The hose assembly covered by this specification is for supplying breathing oxygen to aircrew members during the operation of aircraft. The hose assembly extends from the breathing regulator to the application connector. These hose assemblies are part of the Aircraft Life Support System..
There has been a two vehicle crash on the A158 by Hatton, in between Wragby and Horncastle.
Police were called to the crash, involving a white Nissan and a blue Rover, at 4.16pm today, Tuesday, November 20.
Drivers are being treated for minor injuries on the scene.
The site is currently being cleared by Lincolnshire Police, as of 5.40pm.
The road remains open, although drivers should avoid the area as there is traffic disruption that has been caused by the incident.
Ryan Beaumont tweeted to say: "Accident again on the A158 just as you come out of Wragby - there’s a car in the middle on the road, beware for it right on the corner!"
We'll release more details when they come in.
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How long does it take the flu to evade a vaccine?
With all the recent Presidential attention to the threat from the H5N1 Avian Flu, and the many billions now earmarked for stockpiling vaccines and drugs, it seems like a good idea to ask on what time scale the virus might be able to evade these countermeasures. Vaccination is of particular interest, as it is regarded as by far the best tool to combat viral infection at the population level.
Genomic analyses of H5N1 isolates from birds and humans showed 2 distinct clades with a nonoverlapping geographic distribution. All the viral genes were of avian influenza origin, which indicates absence of reassortment with human influenza viruses.
Genetic and antigenic analyses have shown that, compared to previous H5N1 isolates, 2004-2005 isolates share several amino acid changes that modulate antigenicity and perhaps other biological function. Furthermore, our molecular analysis of the HA from isolates collected in 2005 suggests that several amino acids located near the receptor-binding site are undergoing change, some of which may affect antigenicity or transmisibility.
Despite the recent "Isolation of drug-resistant H5N1 virus," (Nature, 20 October 2005), the WHO Global Influenza team determined that recent isolates are "sensitive to 2 neuraminidase inhibitors that are recommended for prophylactic or therapeutic intervention against human infections." So obviously the specific details of which viral isolate one is working with determine its sensitivity to drugs. In the case of the drug-resistant strain, it was isolated in February 2005 from a Vietnamese girl who may have contracted the virus while she cared for her brother. Human-to-human transmission is supported by the girl's lack of contact with poultry and the fact that the neuraminidase gene from virus isolated from the girl was virtually identical to that isolated from her brother. Thus there are evidently drug resistant strains running around in the wild.
As far as I can tell, it just isn't yet clear how fast drug-resistance traits can spread. There is now at least a little data about how long it takes a particular viral strain to find work-arounds for vaccines. A recent initial effort to sequence many flu strains in parallel indicates that mutations that provide ways around vaccines can rapidly dominate a population of flu viruses.
Perhaps the most dramatic finding in our data is the discovery of an epidemiologically significant reassortment that explains the appearance, during the 2003-2004 season, of the 'Fujian/411/2002'-like strain, for which the existing vaccine had limited effectiveness. ...Phylogenetic analysis of 156 H3N2 genomes from our project revealed the clear presence of multiple, distinct clades circulating in the population. Through a reassortment event, a minor clade provided the haemagglutinin gene that later became part of the dominant strain after the 2002-2003 season.
This finding illustrates not only that the influenza virus population contains multiple lineages at any given time, but also that alternate, minor lineages can contribute genetic variation to the dominant lineage, resulting in epidemiologically significant, antigenically novel strains. It is worth emphasizing that our sequence-based sampling approach--in contrast to traditional serologically based sampling--will reveal co-circulating strains even before they become antigenically novel.
In other words, the authors assert that amongst viruses that we give the same name there is considerable variation that may be hard to distinguish using traditional techniques. Sequencing the genomes of many isolates can provide a map of how a population of viruses is changing in response to vaccines. Ghedin, et al., note that their work demonstrates significant change of the dominant flu strain even within the 2003-2004 flu season. That variation appeared to originate and then dominate the population of viruses within 12 months.
Which brings me to the core of this post, namely that we now have real-world data demonstrating that flu viruses can escape vaccines in less than a year, far shorter than the time it takes to produce significant quantities of effective vaccines. It is important to note that this is a different problem than producing a new vaccine for new annual flu strains every year. If a pandemic strain emerges, our problem is not planning ahead just far enough to deploy a vaccine for next year's strain, but rather to combat a strain already killing people worldwide. It took most of a year for the CDC and Sanofi to come up with a hypothetical H5N1 vaccine, and the new National Strategy for Pandemic Influenza contains the expectation of years to accumulate enough vaccine to be useful for large populations. Never mind that the existing whole virus vaccine may not be effective against a pandemic strain.
The fact that the minor Fujian-like clade has donated its HA to the previously dominant strain rather than itself becoming the dominant circulating virus indicates that there may be important amino acid co-substitutions in the other proteins essential for viral fitness.
...Even within a geographically constrained set of isolates, we have found surprising genetic diversity, indicating that the reservoir of influenza A strains in the human population -- and the concomitant potential for segment exchange between strains -- may be greater than was previously suspected.
We cannot think of the H5N1, or any other strain, as either a clonal population experiencing selection or as a bunch of individuals producing descendants that may accumulate mutations leading to a pandemic strain. Rather, flu viruses exists as elements of a population that appear to be constantly innovating and trading parts. This is a critical distinction, particularly in light of rapid human and avian intercontinental travel. Not only have we now learned that there is greater variation in any given set of geographically linked isolates, but because of human travel we can expect all kinds of novel parts to show up in populations that were otherwise isolated and appeared to be of no immediate threat.
The Ghedin paper doesn't necessarily teach us directly about the evolution of pandemic flu strains, but it does suggest our current plan for pandemic vaccination is not well suited for the problem at hand.
After studying synthetic vaccines for Bio-ERA, amongst other clients, I think DNA vaccines are the best bet for rapid response on a time scale shorter than flu strains seem to evolve. I've a draft paper on synthetic vaccines in for consideration at Biosecurity and Bioterrorism, and will shortly embark on another paper specifically about distributed manufacture of DNA vaccines. PowderMed is waiting for publication of their (already accepted) first paper on their plasmid vaccine for the annual flu and will be starting trials of an H5N1 DNA vaccine early next year. Unfortunately, it seems the folks in DC aren't taking this technology seriously, and instead blowing billions on developing cell culture production of whole virus vaccines. Even the folks who manufacture vaccines in cell culture acknowledge this will only cut a month or two off the response time.
View Full Information → Sydney, Stanley H.
Dianne (Morretti) Dingolo, of Saugus, the retired Principal of the Cheverus School in Malden, died Saturday morning at Lighthouse Nursing Care Center, Revere. She was 68. Born and raised in Lynn, Dianne spent most of her life as an educator.
RAYNHAM – John M. Valadao, longtime Raynham resident, died at Tufts – New England Medical Center in Boston on Jan. 20, 2012. He was 82. Born in Taunton, he was the son of the late Manuel M. and Maria R.
Kelly, Elena M. (DiBiase) of Jamaica Plain on January 21, 2012. Beloved wife of the late Daniel E. Kelly. Loving mother of Janet O’Brien and her husband Paul of Brockton and Daniel J. Kelly and his wife Gail of Sharon.
View Full Information → Sagarin, Bart S.
well it was big fat electric, for sure. Very techno, mathematical sounding. Sort of maddening but I like it. I could see it as one of those Chariot of Fire style film backings.
No salutation DET. DR. MISS MR. MRS. MS. REV.
To protect your personal information, passwords/passphrases must be at least 8 characters long and include at least one letter and at least one digit. Spaces and basic punctuation are okay. It is recommended that you create a passphrase that is easy to remember but hard to guess (e.g,, ""I l0ve Pit Bull$"") rather than a regular password, and that you not use your name or common words like ""password"" in it.
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