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In temperate climates , winter deaths exceed summer ones . However , there is limited information on the timing and the relative magnitudes of maximum and minimum mortality , by local climate , age group , sex and medical cause of death . We used geo-coded mortality data and wavelets to analyse the seasonality of morta... | In the USA , more deaths happen in the winter than the summer . But when deaths occur varies greatly by sex , age , cause of death , and possibly region . Seasonal differences in death rates can change over time due to changes in factors that cause disease or affect treatment . Analyzing the seasonality of deaths can h... |
Whether complement dysregulation directly contributes to the pathogenesis of peripheral nervous system diseases , including sensory neuropathies , is unclear . We addressed this important question in a mouse model of ocular HSV-1 infection , where sensory nerve damage is a common clinical problem . Through genetic and ... | Most people have likely experienced the discomfort of an eyelash falling onto the surface of their eye . Or that gritty sensation when dust blows into the eye and irritates the surface . These sensations are warnings from sensory nerves in the cornea , the transparent tissue that covers the iris and pupil . Corneal ner... |
Variation in the presentation of hereditary immunodeficiencies may be explained by genetic or environmental factors . Patients with mutations in HOIL1 ( RBCK1 ) present with amylopectinosis-associated myopathy with or without hyper-inflammation and immunodeficiency . We report that barrier-raised HOIL-1-deficient mice ... | The immune system protects an individual from invading bacteria , viruses and parasites , as well as malfunctioning or cancerous host cells . However , some people inherit genetic defects that cause part of the immune system to be missing or to not work properly . This is called a genetic immunodeficiency , and puts in... |
Rapid and flexible interpretation of conflicting sensory inputs in the context of current goals is a critical component of cognitive control that is orchestrated by frontal cortex . The relative roles of distinct subregions within frontal cortex are poorly understood . To examine the dynamics underlying cognitive contr... | The brain adapts to control our behavior in different ways depending on the specific situation , which is particularly useful when deciding how to interpret conflicting sets of information . The 'Stroop task' is a classic demonstration of this process . In this task , individuals are shown words where the color and the... |
"Myosin 5a is a dual-headed molecular motor that transports cargo along actin filaments . By followi(...TRUNCATED) | "Cells use motor proteins that to move organelles and other cargos from one place to another . The m(...TRUNCATED) |
"The latent reservoir is a major barrier to HIV cure . As latently infected cells cannot be phenotyp(...TRUNCATED) | "There is no cure for the human immunodeficiency virus infection ( HIV ) , but anti-retroviral drugs(...TRUNCATED) |
"Object manufacture in insects is typically inherited , and believed to be highly stereotyped . Opti(...TRUNCATED) | "Male tree crickets produce sounds at a specific pitch to attract females . The louder the call , th(...TRUNCATED) |
"Missense mutations of valosin-containing protein ( VCP ) cause an autosomal dominant disease known (...TRUNCATED) | "A disease called “inclusion body myopathy , Paget disease and frontotemporal dementia ( IBMPFD ) (...TRUNCATED) |
"Mammals produce volatile odours that convey different types of societal information . In Homo sapie(...TRUNCATED) | "Human body odour contains a number of chemicals , but the most pungent and recognisable are thioalc(...TRUNCATED) |
"Monocytes are phagocytic effector cells in the blood and precursors of resident and inflammatory ti(...TRUNCATED) | "White blood cells form part of the immune system , which protects the body against infectious disea(...TRUNCATED) |
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