pubid int32 113k 27.9M | question stringlengths 17 664 | context dict | long_answer stringlengths 1 3.34k | final_decision stringclasses 2
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25,425,321 | Does prolonged P wave duration predict stroke mortality among type 2 diabetic patients with prevalent non-major macrovascular disease? | {
"contexts": [
"Prolonged P wave duration is a marker of delayed inter-atrial conduction which may predict cardiovascular disease (CVD). Type 2 diabetes is a risk factor for all atherosclerotic manifestations including stroke. We evaluated the prognostic significance of prolonged P wave duration among middle-age... | As an easily measurable factor P wave duration merits further studies with higher number of patients to evaluate its importance in the estimation of stroke risk in type 2 diabetic patients with PNMMVD. | yes |
25,447,449 | Do central adenosine A1 and A2A receptors mediate the antinociceptive effects of neuropeptide S in the mouse formalin test? | {
"contexts": [
"The present study aimed to investigate the intraplantar (ipl) and central (icv) effects of neuropeptide S (NPS) in the formalin test and to evaluate the role of adenosine receptors, mainly A1 and A2A, in mediating such effects.",
"The ipl injection of formalin was used to assess the nocicepti... | The above findings suggest that: (i) NPS evokes central antinociceptive effects by activating both A1 and A2A receptors during phase 1, but (ii) only the adenosine A2A receptor during phase 2 of the formalin test. | yes |
25,443,746 | Does experimental diabetes mellitus type 1 increase hippocampal content of kynurenic acid in rats? | {
"contexts": [
"Diabetes mellitus (DM) is frequently associated with peripheral and central complications and has recently emerged as a risk factor for cognitive impairment and dementia. Kynurenic acid (KYNA), a unique tryptophan derivative, displays pleiotropic effects including blockade of ionotropic glutamate... | A novel factor potentially implicated in diabetic hippocampal dysfunction has been identified. Observed increase of KYNA level may stem from the activation of endogenous neuroprotection, however, it may also have negative impact on cognition. | yes |
25,445,962 | Does blockade of p38 mitogen-activated protein kinase pathway ameliorate delayed gastric emptying in streptozotocin-induced diabetic rats? | {
"contexts": [
"Gastrointestinal dysfunction is one of the major complications of diabetes. The roles of inflammation in diabetes and its associated complications are increasingly recognized. p38 mitogen-activated protein kinase (MAPK) has been shown to be involved in the production of pro-inflammatory mediators... | Inflammation was associated with the development of delayed gastric emptying, and blockade of p38 MAPK pathway with SB203580 ameliorates delayed gastric emptying in diabetic rats, at least in part, by inhibiting the expression of iNOS, TNF-a and IL-1β. Therefore, p38MAPK may serve as a novel target for the therapy of d... | yes |
25,423,087 | Is high level of plasma matrix metalloproteinase-11 associated with clinicopathological characteristics in patients with oral squamous cell carcinoma? | {
"contexts": [
"Matrix metalloproteinase-11 (MMP-11) is reported to be overexpressed in several cancers and may contribute to tumorigenesis. The current study investigated the association between the clinicopathological characteristics and plasma level of MMP-11 in oral squamous cell carcinoma (OSCC) patients.",... | Our study showed that plasma level of MMP-11 may be useful for assessment of the disease progression, especially lymph node metastasis, in patients with OSCC. | yes |
25,446,338 | Is interferon lambda-3 associated with clinical outcome in patients with HCV-induced compensated cirrhosis : a long-term cohort study? | {
"contexts": [
"Interferon Lambda-3 (IFN-λ3) gene polymorphism is associated with spontaneous clearance of hepatitis C virus (HCV) and response to IFN-based therapy (IFN). However, very few data are available about its value in predicting sustained virologic response (SVR) in patients with cirrhosis, and whether... | IFN-λ3 determination is fundamental for allocating cirrhotic patients to be treated with IFN, while it has no value in predicting the outcome of the disease. | no |
25,444,169 | Does dorsomedial Prefrontal Cortex mediate the Impact of Serotonin Transporter Linked Polymorphic Region Genotype on Anticipatory Threat Reactions? | {
"contexts": [
"Excessive anticipatory reactions to potential future adversity are observed across a range of anxiety disorders, but the neurogenetic mechanisms driving interindividual differences are largely unknown. We aimed to discover and validate a gene-brain-behavior pathway by linking presumed genetic ris... | The converging results from these experiments demonstrate that innate 5-HTTLPR linked variation in dmPFC activity predicts psychophysiological responsivity to pending threats. Our results reveal a neurogenetic pathway mediating interindividual variability in anticipatory responses to threat and yield a novel mechanisti... | yes |
25,451,672 | Does intensity-modulated whole pelvic radiotherapy provide effective dosimetric outcomes for cervical cancer treatment with lower toxicities? | {
"contexts": [
"To compare the efficacy of intensity-modulated radiotherapy, three-dimensional conformal radiotherapy, and conventional radiotherapy for cervical cancer treatment.",
"Whole pelvis intensity-modulated radiotherapy, three-dimensional conformal radiotherapy, and conventional radiotherapy plans w... | An intensity-modulated radiotherapy plan with appropriate margins encompassing the primary tumour and potential microscopic pelvic disease reduces the dose to organs at risk without compromising target coverage. Intensity-modulated radiotherapy is an appropriate definitive treatment for patients with cervical cancer. | yes |
25,433,014 | Does treatment with anti-C5a antibody improve the outcome of H7N9 virus infection in African green monkeys? | {
"contexts": [
"Patients infected with influenza A(H7N9) virus present with acute lung injury (ALI) that is due to severe pneumonia and systemic inflammation. It is often fatal because there are few effective treatment options. Complement activation has been implicated in the pathogenesis of virus-induced lung i... | Antihuman C5a antibody treatment remarkably reduced the ALI and systemic inflammation induced by H7N9 virus infection. Complement inhibition may be a promising adjunctive therapy for severe viral pneumonia. | yes |
25,428,334 | Are socioeconomic inequalities still a barrier to full child vaccine coverage in the Brazilian Amazon : a cross-sectional study in Assis Brasil , Acre , Brazil? | {
"contexts": [
"Vaccines are very important to reduce morbidity and mortality by preventable infectious diseases, especially during childhood. Optimal coverage is not always achieved, for several reasons. Here we assessed vaccine coverage for the first 12 months of age in children between 12 and 59 months old, r... | This study showed that vaccine coverage in the first twelve months of life in Assis Brasil is similar to other areas in the Amazon and it is below the coverage postulated by the Brazilian Ministry of Health. Low vaccine coverage was associated with socioeconomic inequities that still prevail in the Brazilian Amazon. Sh... | yes |
25,425,259 | Does mental fatigue affect maximal anaerobic exercise performance? | {
"contexts": [
"Mental fatigue can negatively impact on submaximal endurance exercise and has been attributed to changes in perceived exertion rather than changes in physiological variables. The impact of mental fatigue on maximal anaerobic performance is, however, unclear. Therefore, the aim of the present stud... | Near identical responses in performance and physiological parameters between mental fatigue and control conditions suggest that peripheral mechanisms primarily regulate maximal anaerobic exercise. Whereas mental fatigue can negatively impact submaximal endurance exercise, it appears that explosive power, voluntary maxi... | no |
25,436,609 | Is tP53 Pro72 allele enriched in oral tongue cancer and frequently mutated in esophageal cancer in India? | {
"contexts": [
"The tumor suppressor p53 is known to be inactivated frequently in various cancers. In addition, germline polymorphisms in TP53 are known to affect protein function and influence risk of developing different types of cancers. In this study, we analyzed the association of TP53 Pro72Arg polymorphism... | Our study revealed the association of Pro72 allele with SCCOT suggesting the effect of this polymorphism on SCCOT risk. Preferential mutation of Pro72 allele exclusively in ESCC indicates the need for further studies to understand the tissue specific effect of p53 polymorphism. | yes |
25,446,184 | Does α-Enolase play a catalytically independent role in doxorubicin-induced cardiomyocyte apoptosis and mitochondrial dysfunction? | {
"contexts": [
"α-Enolase is a glycolytic enzyme with \"second jobs\" beyond its catalytic activity. However, its possible contribution to cardiac dysfunction remains to be determined. The present study aimed to investigate the role of α-enolase in doxorubicin (Dox)-induced cardiomyopathy as well as the underlyi... | Our findings provided the evidence that α-enolase has a catalytically independent role in inducing cardiomyocyte apoptosis and mitochondrial dysfunction, which could be at least partially contributed to the inhibition of AMPK phosphorylation. | yes |
25,433,681 | Do a qualitative study of the background and in-hospital medicolegal response to female burn injuries in India? | {
"contexts": [
"Most burns happen in low- and middle-income countries. In India, deaths related to burns are more common in women than in men and occur against a complex background in which the cause - accidental or non-accidental, suicidal or homicidal - is often unclear. Our study aimed to understand the antec... | The similarities between accident and intention cluster so tightly as to make them challenging to distinguish, especially given women's understandable reticence to describe burns as non-accidental. The contested status of forensic evidence and a reliance on testimony means that only a minority of cases lead to convicti... | yes |
25,450,037 | Is african-american race a predictor of seminal vesicle invasion after radical prostatectomy? | {
"contexts": [
"The purpose of the study was to determine whether racial differences exist in the pattern of local disease progression among men treated with radical prostatectomy (RP) for localized prostate cancer (PCa), which is currently unknown. In this study we evaluated the pattern of adverse pathologic fe... | AA men have an increased risk of SVI after RP, particularly among men with Gleason ≤ 6 disease. This might represent racial differences in the biology of PCa disease progression, which contribute to poorer outcomes in AA men. | yes |
25,432,074 | Is self-rated health associated with the length of stay at the intensive care unit and hospital following cardiac surgery? | {
"contexts": [
"Recently, a considerable amount of evidence suggested that anxiety, depression and other psychosocial variables might influence the outcomes of cardiac surgery. This study investigated the relationship between length of stay at the intensive care unit (ICU) and hospital after surgery and differen... | Lower happiness and self-rated health may influence the outcome of cardiac surgery. Therefore, these variables should be assessed in patients. | yes |
25,445,155 | Is integrin-based meningioma cell migration promoted by photon but not by carbon-ion irradiation? | {
"contexts": [
"Sublethal doses of photon irradiation (IR) are suspected to increase tumor cell migration and support locoregional recurrence of disease, which has already been shown in other cell lines. This manuscript describes the effect of photon and carbon-ion IR on WHO class I meningioma cell migration and... | Photon but not carbon-ion IR promotes serum-based meningioma cell migration. Fibronectin receptor integrin ανβ1 signaling can be identified as an important mechanism for serum- and photon-induced migration of WHO class I meningioma cells. | yes |
25,443,141 | Does early-life stress selectively affect gastrointestinal but not behavioral responses in a genetic model of brain-gut axis dysfunction? | {
"contexts": [
"Early-life stress and a genetic predisposition to display an anxiety- and depressive-like phenotype are associated with behavioral and gastrointestinal (GI) dysfunction. Animals exposed to early-life stress, and those genetically predisposed to display anxiety or depressive behaviors, have proven... | Our data suggest that early-life stress, on the background of a genetic predisposition to display an anxiety- and depressive-like phenotype, selectively influences GI function rather than stress-related behaviors. Thus, our findings highlight the importance of genetic predisposition on the outcome of early-life adversi... | yes |
25,449,247 | Are historic and current hepatitis B viral DNA and quantitative HBsAg level associated with cirrhosis in non-Asian women with chronic hepatitis B? | {
"contexts": [
"Some studies done in Asian patients have shown that serum levels of hepatitis B virus (HBV) DNA predict the development of cirrhosis. However, it is unclear whether this also applies for non-Asian patients. This study investigated historic and current HBV DNA and quantitative hepatitis B surface ... | Neither historic nor current HBV DNA or the quantitative HBsAg level is associated with the development of HBV-related cirrhosis in non-Asian women. | no |
25,428,555 | Does patatin-related phospholipase pPLAIIIδ influence auxin-responsive cell morphology and organ size in Arabidopsis and Brassica napus? | {
"contexts": [
"The members of the patatin-related phospholipase subfamily III (pPLAIIIs) have been implicated in the auxin response. However, it is not clear whether and how these genes affect plant and cell morphogenesis. Here, we studied the roles of the patatin-related phospholipase pPLAIIIδ in auxin-respons... | These data suggest that the PLAIIIδ gene plays an important role in cell morphology and organ size through its involvement in the regulation of auxin distribution in plants. | yes |
25,443,925 | Does histoscanning have low sensitivity and specificity for seminal vesicle invasion? | {
"contexts": [
"To examine the accuracy of HistoScanning (HS) in detecting seminal vesicle (SV) invasion (SVI) within prostate cancer (PCa) patients.",
"We relied on our prospective institutional database. Patients who received HS before radical prostatectomy were included in the study cohort. An experienced... | HS results did not allow a reliable prediction of SVI within PCa patients. Despite, the application of HS signal volume cut-offs (>0.2 and >0.5 mL), the prediction of SVI within PCa patients remained insufficient. | yes |
25,443,923 | Is low percentage of free prostate-specific antigen ( PSA ) a strong predictor of later detection of prostate cancer among Japanese men with serum levels of total PSA of 4.0 ng/mL or less? | {
"contexts": [
"To investigate the effect of the percentage of free prostate-specific antigen (%fPSA) on future prostate cancer risk.",
"We examined serum total PSA (tPSA) and %fPSA annually in a prostate cancer-screening cohort between July 2001 and June 2011. Men with tPSA >4.0 ng/mL or tPSA of 2.0-4.0 ng/... | A low %fPSA is a strong predictor of a subsequent diagnosis of prostate cancer among men with tPSA levels ≤4.0 ng/mL. Measurement of %fPSA might enhance the detection of high-grade cancer that warrants aggressive treatment. | yes |
25,446,158 | Is permanent His-bundle pacing feasible , safe , and superior to right ventricular pacing in routine clinical practice? | {
"contexts": [
"Right ventricular pacing (RVP) has been associated with heart failure and increased mortality. His-bundle pacing (HBP) is more physiological but requires a mapping catheter or a backup right ventricular lead and is technically challenging.",
"We sought to assess the feasibility, safety, and c... | Permanent HBP without a mapping catheter or a backup right ventricular lead was successfully achieved in 80% of patients. PTh was higher and FT was comparable to those of the RVP group. Clinical outcomes were better in the HBP group than in the RVP group. | yes |
25,446,153 | Are clinical and serum-based markers associated with death within 1 year of de novo implant in primary prevention ICD recipients? | {
"contexts": [
"Implantable cardioverter-defibrillator (ICD) implantation is contraindicated in those with <1-year life expectancy.",
"The aim of this study was to develop a risk prediction score for 1-year mortality in patients with primary prevention ICDs and to determine the incremental improvement in dis... | Individuals with more comorbidities and elevation of specific serum biomarkers were at increased risk of all-cause mortality despite being deemed as having a reasonable 1-year life expectancy. A simple risk score composed of readily available clinical data and serum biomarkers may better identify patients at high risk ... | yes |
25,450,180 | Does astaxanthin prevent TGFβ1-induced pro-fibrogenic gene expression by inhibiting Smad3 activation in hepatic stellate cells? | {
"contexts": [
"Non-alcoholic steatohepatitis (NASH) is a subset of non-alcoholic fatty liver disease, the most common chronic liver disease in the U.S. Fibrosis, a common feature of NASH, results from the dysregulation of fibrogenesis in hepatic stellate cells (HSCs). In this study, we investigated whether asta... | Taken together, ASTX exerted anti-fibrogenic effects by blocking TGFβ1-signaling, consequently inhibiting the activation of Smad3 pathway in HSCs. | yes |
25,442,486 | Is vitamin D deficiency in mycosis fungoides and Sézary syndrome patients similar to other cancer patients? | {
"contexts": [
"The purpose of this study was to determine the prevalence of vitamin D deficiency in CTCL patients and whether supplementation corrects vitamin D deficiency or treatment outcome.",
"Three hundred eleven CTCL patients including 27/311 (8.7%) with Sézary syndrome (SS), 169 cancer controls, and ... | To our knowledge,this is the first study of vitamin D status in CTCL patients. Vitamin D deficiency was present in CTCL and other cancer patients compared with normal and historical controls. Correction of vitamin D deficiency and type of vitamin D supplementation used did not affect the overall clinical disease respon... | yes |
25,451,450 | Does genome wide association study identify variants in NBEA associated with migraine in bipolar disorder? | {
"contexts": [
"Migraine is a common comorbidity among individuals with bipolar disorder, but the underlying mechanisms for this co-occurrence are poorly understood. The aim of this study was to investigate the genetic background of bipolar patients with and without migraine.",
"We performed a genome-wide as... | Our study is based on self-reported migraine. | yes |
25,429,853 | Is nASH resolution associated with improvements in HDL and triglyceride levels but not improvement in LDL or non-HDL-C levels? | {
"contexts": [
"Nonalcoholic steatohepatitis (NASH) is associated with dyslipidemia and cardiovascular disease (CVD).",
"To determine the relationship between resolution of NASH and dyslipidemia.",
"Individuals in the Pioglitazone vs. Vitamin E vs. Placebo for the Treatment of Nondiabetic Patients with N... | NASH resolution is associated with improvements in TG and HDL but not in other cardiovascular disease risk factors including LDL and non-HDL-C levels. Individuals with resolution of NASH may still be at increased risk of cardiovascular disease. ClinicalTrials.gov identifier: NCT00063622. | yes |
25,424,750 | Is aberrant P-cadherin expression associated to aggressive feline mammary carcinomas? | {
"contexts": [
"Cadherins are calcium-dependent cell-to-cell adhesion glycoproteins playing a critical role in the formation and maintenance of normal tissue architecture. In normal mammary gland, E-cadherin is expressed by luminal epithelial cells, while P-cadherin is restricted to myoepithelial cells. Changes ... | The results demonstrate a relationship between P-cadherin expression and aggressive biological behaviour of feline mammary carcinomas, suggesting that P-cadherin may be considered an indicator of poor prognosis in this animal species. Moreover, it indicates that, in queens, the aberrant expression of P-cadherin is a be... | yes |
25,446,583 | Does casticin inhibit COX-2 and iNOS expression via suppression of NF-κB and MAPK signaling in lipopolysaccharide-stimulated mouse macrophages? | {
"contexts": [
"The fruits of Vitex rotundifolia L. are widely used to treat inflammation of the airway in Traditional Chinese medicine. Previous studies found that casticin, isolated from Vitex rotundifolia, could induce apoptosis of tumor cells. In this study, we evaluated the anti-inflammatory effects of cast... | These results suggest that the anti-inflammatory effect of casticin is due to inhibition of proinflammatory cytokines and mediators by blocking the NF-κB, Akt, and MAPK signaling pathways. | yes |
25,431,836 | Do transcriptome sequencing and comparative analysis reveal long-term flowing mechanisms in Hevea brasiliensis latex? | {
"contexts": [
"The rubber tree, Hevea brasiliensis, is a major commercial source of natural rubber. Increasing the rubber yield of rubber trees is a very serious problem since the demands for high quality rubber materials are great. Establishment of a tapping system is based on an estimate of tapping intensity ... | We conducted high-resolution transcriptome profiling related to LFL in H. brasiliensis. The research facilitates further studies on gene discovery and on the molecular mechanisms related to the estimation of tapping intensity and prolonging latex flowing time. We concluded that it was necessary to improve energy suppli... | yes |
25,425,111 | Does cannabidiol fail to reverse hypothermia or locomotor suppression induced by Δ ( 9 ) -tetrahydrocannabinol in Sprague-Dawley rats? | {
"contexts": [
"Growing evidence shows cannabidiol (CBD) modulates some of the effects of Δ(9) -tetrahydrocannabinol (THC). CBD is a constituent of some strains of recreational cannabis but its content is highly variable. High CBD strains may have less memory-impairing effects than low-CBD strains and CBD can re... | There is no evidence from this study that elevated CBD content in cannabis could provide protection from the physiological effects of THC, in rats. | yes |
25,422,913 | Does miR-1228 promote the proliferation and metastasis of hepatoma cells through a p53 forward feedback loop? | {
"contexts": [
"The effective mechanisms of microRNAs (miRNAs) functions as oncogenes or tumour suppressors in human hepatocellular carcinoma (HCC) are still obscure. Here, we investigated the function and expression of miR-1228 in HCC.",
"The role of miR-1228 in HCC was determined by colony formation, trans... | miR-1228 functions as an oncogene by promoting cell cycle progression and cell mobility and negatively regulates the expression of p53. p53 downregulation in turn leads to an increase in miR-1228 expression, thereby forming a positive feedback loop that contributes to cancerogenesis in HCC. | yes |
25,430,449 | Does over-expression of small ubiquitin-like modifier proteases 1 predict chemo-sensitivity and poor survival in non-small cell lung cancer? | {
"contexts": [
"Non-small cell lung cancer (NSCLC) is one of the most common malignant tumors. Despite the advances in therapy over the years, its mortality remains high. The aim of this study was to evaluate the expression of small ubiquitin-like modifier (SUMO) proteases 1 (SENP1) in NSCLC tissues and its role... | SENP1 may be a promising predictor of survival, a predictive factor of chemo-sensitivity for NSCLC patients, and potentially a desirable drug target for lung carcinoma target therapy. | yes |
25,428,027 | Is wnt signaling involved in 6-benzylthioinosine-induced AML cell differentiation? | {
"contexts": [
"We previously demonstrated that 6-benzylthioinosine (6-BT) could induce the differentiation of a subset of acute myeloid leukemia (AML) cell lines and primary AML cells regardless of their cytogenetics. In this study we investigated whether Wnt signaling pathways played roles in 6-BT-induced diff... | Both canonical and non-canonical Wnt signaling were involved in 6-BT-induced differentiation of HL-60 cells, and played opposite roles in this process. Wnt signaling could be involved in the pathogenesis of AML not only by regulating self-renewal of hematopoietic stem cells, but also by playing a role in the differenti... | yes |
25,442,300 | Does ginsenoside Rg3 improve erectile function in streptozotocin-induced diabetic rats? | {
"contexts": [
"Ginsenoside Rg3 is one of the active ingredients isolated from Panax ginseng C.A. Meyer. Previous studies demonstrated that Rg3 has antioxidant and neuroprotective abilities.",
"The purpose of this study was to evaluate the protective effect of Rg3 on erectile function in streptozotocin (STZ)... | Oral gavage with Rg3 appears to both prevent degeneration of neurons in the dorsal nerves and exert an antioxidant effect in the corpus cavernosum of rats. | yes |
25,429,984 | Does serum alanine aminotransferase predict the histological course of non-alcoholic steatohepatitis in Japanese patients? | {
"contexts": [
"Some cases with non-alcoholic fatty liver disease (NAFLD), particularly non-alcoholic steatohepatitis (NASH), can ultimately progress to liver cirrhosis. However, studies to clarify factors predictive of histological change in patients with NASH remain scarce. Our aim is to determine predictors o... | A lack of reduction in serum ALT level by at least 30% from baseline was a predictor for histological progression in patients with NASH. Serum ALT level is a better predictor of histological change than insulin resistance or bodyweight and can be a valid index in treatment. Serum ALT should be strictly controlled to pr... | yes |
25,446,530 | Does hepatic Notch2 deficiency lead to bile duct agenesis perinatally and secondary bile duct formation after weaning? | {
"contexts": [
"Notch signaling plays an acknowledged role in bile-duct development, but its involvement in cholangiocyte-fate determination remains incompletely understood. We investigated the effects of early Notch2 deletion in Notch2(fl/fl)/Alfp-Cre(tg/-) (\"Notch2-cKO\") and Notch2(fl/fl)/Alfp-Cre(-/-) (\"co... | Cholangiocyte differentiation becomes progressively less dependent on NOTCH2 signaling with age, suggesting that ductal-plate formation is dependent on NOTCH2, but subsequent cholangiocyte differentiation is not. | yes |
25,450,716 | Does recipient T cell TIM-3 and hepatocyte galectin-9 signalling protect mouse liver transplants against ischemia-reperfusion injury? | {
"contexts": [
"By binding to T cell immunoglobulin mucin-3 (TIM-3) on activated Th1 cells, galectin-9 (Gal-9) negatively regulates Th1-type alloimmunity. Although T cells contribute to hepatic ischemia-reperfusion injury (IRI), it is unknown whether negative T cell-dependent TIM-3 co-stimulation may rescue IR-s... | Harnessing TIM-3/Gal-9 signalling at the T cell-hepatocyte interface facilitates homeostasis in IR-stressed orthotopic liver transplants. Enhancing anti-oxidant hepatocyte Gal-9 potentiates liver IR-resistance. Negative regulation by recipient TIM-3+CD4+ cells provides evidence for cytoprotective functions of a discret... | yes |
25,447,971 | Does contrast enhancement pattern on multidetector CT predict malignancy in pancreatic endocrine tumours? | {
"contexts": [
"Preoperative suspicion of malignancy in pancreatic neuroendocrine tumours (pNETs) is mostly based on tumour size. We retrospectively reviewed the contrast enhancement pattern (CEP) of a series of pNETs on multiphasic multidetector computed tomography (MDCT), to identify further imaging features p... | Correlating with the lesion grading and other histological prognostic predictors, CEP may preoperatively suggest the behaviour of pNETs, assisting decisions about treatment. Moreover CEP allows recognition of malignant small tumours, incorrectly classified on the basis of their dimension. | yes |
25,427,956 | Does ketamine inhibit proliferation of neural stem cell from neonatal rat hippocampus in vitro? | {
"contexts": [
"Ketamine is a widely used anesthetic in obstetric and pediatric anesthesia. In the developing brain, the widespread neuron apoptosis triggered by ketamine has been demonstrated. However, little is known about its effect on neural stem cells (NSCs) function. This study aimed to investigate the eff... | Ketamine inhibited proliferation of NSCs from neonatal rat hippocampus in vitro. Suppressing Ca(2+)-PKCα-ERK1/2 signaling pathway may be involved in this inhibitory effect of ketamine on NSCs proliferation. | yes |
25,427,527 | Does iTRAQ-based quantitative proteome and phosphoprotein characterization reveal the central metabolism changes involved in wheat grain development? | {
"contexts": [
"Wheat (Triticum aestivum L.) is an economically important grain crop. Two-dimensional gel-based approaches are limited by the low identification rate of proteins and lack of accurate protein quantitation. The recently developed isobaric tag for relative and absolute quantitation (iTRAQ) method al... | Our results revealed a complex quantitative proteome and phosphorylation profile during wheat grain development. Numerous DEPs are involved in grain starch and protein syntheses as well as adverse defense, which set an important basis for wheat yield and quality. Particularly, some key DEPs involved in starch biosynthe... | yes |
25,437,008 | Are low serum 25-hydroxyvitamin d concentrations associated with increased risk for melanoma and unfavourable prognosis? | {
"contexts": [
"Low vitamin D status (serum 25(OH)D concentration) is associated with increased incidence and unfavourable outcome of various types of cancer. However, there are limited data on influence of serum 25(OH)D on risk and prognosis of malignant melanoma.",
"Basal serum 25(OH)D concentrations were ... | Our data support the concept that serum 25(OH)D concentrations are associated with risk and prognosis of melanoma. Whether normalizing serum 25(OH)D concentrations in these patients improves outcomes will require testing in future clinical trials. | yes |
25,428,423 | Does [ Descriptive study of healthcare professionals ' management of tick bite ]? | {
"contexts": [
"Rural primary health centers frequently treat patients with tick bites. This study compares everyday clinical practice at our primary healthcare center to practices recommended by current scientific evidence.",
"To describe the everyday management of tick bites by different healthcare profess... | We conclude that the performance of the healthcare providers that integrate this study does not closely follow general recommendations for extraction, treatment and follow-up care in patients with tick bites. Therefore, there is a need to improve the level of knowledge to ensure quality care in these instances. | yes |
25,443,176 | Do left ventricular end-diastolic pressure and ejection fraction correlate independently with high-sensitivity cardiac troponin-T concentrations in stable heart failure? | {
"contexts": [
"Cardiac troponin is widely accepted as a biomarker of myocyte injury in patients with myocardial ischemia. Patients with congestive heart failure are also associated with elevated cardiac troponin and it is a very sensitive prognostic marker. However, the mechanisms of troponin elevation in patie... | In patients with stable chronic HF, LVEDP and LVEF correlate with the serum concentrations of hs-cTnT, independently of other correlates of elevated plasma concentrations of hs-cTnT. | yes |
25,440,481 | Does image-guided placement of long-term central venous catheters reduce complications and cost? | {
"contexts": [
"The goals of this study were to evaluate the complication rate for intraoperative placement of a long-term central venous catheter (CVC) using intraoperative ultrasound (US) and fluoroscopy and to examine the feasibility for eliminating routine postprocedure chest X-ray.",
"Retrospective data... | This review supports the use of US for CVC placement with fluoroscopy in reducing the rate of procedural complications. Additionally, with fluoroscopic imaging, postprocedural CXR can be eliminated with associated healthcare savings. | yes |
25,428,807 | Does exosome-mediated transfer of miR-10b promote cell invasion in breast cancer? | {
"contexts": [
"Exosomes are 30-100 nm membrane vesicles of endocytic origin, mediating diverse biological functions including tumor cell invasion, cell-cell communication and antigen presentation through transfer of proteins, mRNAs and microRNAs. Recent evidence suggests that microRNAs can be released through c... | Together, our results suggest that a set of specific microRNAs may play an important role in modulating tumor microenvironment through exosomes. Thus, a better understanding of this process may aid in the development of novel therapeutic agents. | yes |
25,423,953 | Does biolimus-eluting stent with biodegradable polymer improve clinical outcomes in patients with acute myocardial infarction? | {
"contexts": [
"To investigate clinical outcomes of coronary intervention using a biolimus-eluting stent (BES) compared with a sirolimus-eluting stent (SES) in patients with acute myocardial infarction (AMI) in the Limus Eluted from A Durable versus ERodable Stent (LEADERS) coating trial at the final 5-year foll... | BES, compared with SES, significantly improved safety and efficacy outcomes in patients with AMI, especially those with STEMI, at 5-year follow-up. | yes |
25,447,441 | Does triptolide inhibit TGF-β1-induced cell proliferation in rat airway smooth muscle cells by suppressing Smad signaling? | {
"contexts": [
"We have reported that triptolide can inhibit airway remodeling in a murine model of asthma via TGF-β1/Smad signaling. In the present study, we aimed to investigate the effect of triptolide on airway smooth muscle cells (ASMCs) proliferation and the possible mechanism.",
"Rat airway smooth mus... | Triptolide may function as an inhibitor of asthma airway remodeling by suppressing ASMCs proliferation via negative regulation of Smad signaling pathway. | yes |
25,443,649 | Are aerobic capacity and upper limb strength reduced in women diagnosed with breast cancer : a systematic review? | {
"contexts": [
"What are typical values of physical function for women diagnosed with breast cancer and how do these compare to normative data?",
"Systematic review with meta-analysis.",
"Women diagnosed with breast cancer who were before, during or after treatment.",
"Physical function was divided i... | Aerobic capacity and upper extremity strength in women diagnosed with breast cancer are generally lower than population norms. Assessment of values for lower extremity strength is less conclusive. As more research is published, expected values for sub-groups by age, treatment, and co-morbidities should be developed. [N... | yes |
25,445,666 | Is same-day intrauterine device placement rarely complicated by pelvic infection? | {
"contexts": [
"To compare rates of pelvic inflammatory disease (PID) among women who did and did not receive an intrauterine device (IUD) the day they sought emergency contraception (EC) or pregnancy testing.",
"Women, 15 to 45 years of age, who sought EC or pregnancy testing from an urban family planning c... | Same-day IUD placement was not associated with higher rates of PID. Concern for asymptomatic STI should not delay IUD placement, and efforts to increase the uptake of this highly effective reversible contraception should not be limited to populations at low risk of STI. | yes |
25,423,015 | Do obese first-degree relatives of patients with type 2 diabetes with elevated triglyceride levels exhibit increased β-cell function? | {
"contexts": [
"Type 2 diabetes mellitus (T2DM) is characterized as a disease continuum that is marked by metabolic changes that are present for several years, sometimes well before frank diagnosis of T2DM. Genetic predisposition, ethnicity, geography, alterations in BMI, and lipid profile are considered importa... | We characterized FDR-T2DM subjects from central Mexico with NGT and revealed a class of obese subjects with elevated TGs and β-cell function, which may precede PT2DM. | yes |
25,441,547 | Do identification of methicillin-resistant Staphylococcus aureus ( MRSA ) strains isolated from burn patients by multiplex PCR? | {
"contexts": [
"Methicillin-resistant Staphylococcus aureus (MRSA) and methicillin-resistant coagulase-negative staphylococci (MRCoNS) as important human pathogens are causes of nosocomial infections worldwide. Burn patients are at a higher risk of local and systemic infections with these microorganisms.",
"... | This study presented a high MRSA rate in the region under investigation. The 16S rRNA-mecA-nuc multiplex PCR is a good tool for the rapid characterization of MRSA strains. This paper emphasizes the need for preventive measures and choosing effective antimicrobials against MRSA and MRCoNS infections in the burn units. | yes |
25,436,461 | Is coexpression of IQ-domain GTPase-activating protein 1 ( IQGAP1 ) and Dishevelled ( Dvl ) correlated with poor prognosis in non-small cell lung cancer? | {
"contexts": [
"IQ-domain GTPase-activating protein 1 (IQGAP1) binds to Dishevelled (Dvl) and functions as a modulator of Dvl nuclear localization in Xenopus embryos. However, the relationship between IQGAP1 and Dvl in tumor tissues is unclear.",
"We used immunohistochemistry to assess the expressions of IQG... | Coexpression of IQGAP1 and Dvl in the cytoplasm and nucleus was correlated with the lymph nodal metastase and poor prognosis of NSCLC, and coexpression in nucleus might play a critical role in the activation of canonical Wnt pathway. | yes |
25,449,451 | Do ethnobotanical survey of medicinal plants used for pregnant women׳s health conditions in Menoua division-West Cameroon? | {
"contexts": [
"In Cameroon, most women use traditional medicine for the treatment of pregnancy and childbirth complaints. In order to identify some of the medicinal plants locally used to alleviate these complaints, an ethnobotanical survey was undertaken in five villages of Menoua Division (West-Cameroon).",
... | Many herbal remedies used for the treatment of pregnant women׳s health conditions in Menoua division-West Cameroon have been revealed. It would therefore be judicious for our government and research institution to evaluate the therapeutic and toxicological potentials of these plants in order to valorize their use. | yes |
25,449,459 | Does shexiang Tongxin dropping pill attenuate atherosclerotic lesions in ApoE deficient mouse model? | {
"contexts": [
"Shexiang Tongxin dropping pill (STDP) is a formulation of Traditional Chinese Medicine mainly used for clinical treatment of stable angina pectoris in China.",
"To investigate the effects and mechanisms of STDP treatment on atherosclerosis.",
"ApoE deficient (ApoE(-/-)) mice were utilized... | Our results demonstrated for the first time that STDP attenuated atherosclerotic lesions in ApoE(-/-) mouse model. Moreover, STDP treatment exhibited multi-targeting effects on pathological, biochemical and molecular aspects of atherosclerosis implicating lipid regulation, fibrosis, inflammation and oxidative stress. F... | yes |
25,439,211 | Do aCTN3 R577X genotypes associate with Class II and deepbite malocclusions? | {
"contexts": [
"α-Actinins are myofibril anchor proteins that influence the contractile properties of skeletal muscles. ACTN2 is expressed in slow type I and fast type II fibers, whereas ACTN3 is expressed only in fast fibers. ACTN3 homozygosity for the 577X stop codon (ie, changing 577RR to 577XX, the R577X pol... | ACTN3 577XX is overrepresented in subjects with skeletal Class II malocclusion, suggesting a biologic influence during bone growth. ACTN3 577XX is underrepresented in subjects with deepbite malocclusion, suggesting that muscle differences contribute to variations in vertical facial dimensions. | yes |
25,442,459 | Is percutaneous intervention of circumflex chronic total occlusions associated with worse procedural outcomes : insights from a Multicentre US Registry? | {
"contexts": [
"We sought to determine whether outcomes of chronic total occlusion (CTO) percutaneous coronary intervention (PCI) vary according to CTO target vessel: left anterior descending artery (LAD), left circumflex artery (LCX), and right coronary artery (RCA).",
"We evaluated the clinical and angiogr... | In a contemporary, multicentre CTO PCI registry, LCX was the least common target vessel. Compared with LAD and RCA, PCI of LCX CTOs was associated with a lower rate of procedural success, less efficiency, and a nonsignificant trend for higher rates of complications. | yes |
25,446,837 | Does fiber supplementation lower plasma p-cresol in chronic kidney disease patients? | {
"contexts": [
"To determine the effects of supplemental fiber on plasma p-cresol, stool frequency, and quality of life (QoL) in chronic kidney disease (CKD) patients.",
"In a 12-week single-blind study, participants were provided with control muffins and supplements (5.5 g sucrose/day) for 2 weeks, muffins ... | Supplementing the diet of CKD patients with fiber may be a dietary therapy to reduce p-cresol and improve stool frequency. | yes |
25,434,364 | Do antiphospholipid antibodies correlate with stroke severity and outcome in patients with antiphospholipid syndrome? | {
"contexts": [
"Our goal was to analyze the association of the level of antiphospholipid antibodies (aPLs) with stroke severity and outcome in patients with antiphospholipid syndrome (APS).",
"Observational study included consecutive patients with ischemic stroke younger than 55 years (2007-2012). We analyze... | In young stroke patients with APS, serum levels of IgM aCL within 48 h are correlated with stroke severity and levels of IgG anti-β2GPI within 48 h are correlated with three-month outcomes. | yes |
25,432,866 | Are `` There bugs in condoms '' : Tanzanian close-to-community providers ' ability to offer effective adolescent reproductive health services? | {
"contexts": [
"Young people in Tanzania are known to access reproductive health services from a range of close-to-community providers outside formal health settings such as drug stores, village AIDS committees, traditional healers and traditional birth attendants (TBAs). However, questions remain about the qual... | Although close-to-community providers are considered a key resource in the community, most have limited capacity to provide ARH services. Without capacity-building investments such as training and cooperation with the mainstream health sector, their contribution to positive reproductive health outcomes is limited, or c... | yes |
25,445,439 | Does engineered heart tissue transplantation alter electrical-conduction function in rats with myocardial infarction? | {
"contexts": [
"To investigate how affects electrical-conduction function following myocardial infarction (MI) in rats.",
"Thirty SD rats of either sex (220-250 g) were anesthetized using chlorine hydrate and were randomly divided into three groups: control group, MI group and transplantation group. The fiel... | EHT transplantation can improve electrical-conduction and function of MI rats. | yes |
25,450,094 | Does protein kinase D1 deficiency promote differentiation in epidermal keratinocytes? | {
"contexts": [
"Protein kinase D (PKD or PKD1) is a serine/threonine protein kinase that has been shown to play a role in a variety of cellular processes; however, the function of PKD1 in the skin has not been fully investigated. The balance between proliferation and differentiation processes in the predominant ... | Cre-recombinase-mediated knockdown represents an additional approach demonstrating that PKD1 is an anti-differentiative, pro-proliferative signal in mouse keratinocytes. | yes |
25,436,343 | Is cD133 expression correlated with poor prognosis in colorectal cancer? | {
"contexts": [
"Cancer stem cells (CSC) was reported to play an important role in various kinds of cancer. CD133 is one of the cancer stem cell markers in solid cancers. However, the correlation between CD133 expression and the clinicopathological factors in colorectal cancer (CRC) remains unclear.",
"Forty ... | CD133 expression is correlated with poor prognosis in CRC. | yes |
25,450,119 | Does atomoxetine reduce hyperactive/impulsive behaviours in neurokinin-1 receptor 'knockout ' mice? | {
"contexts": [
"Mice with functional ablation of the neurokinin-1 receptor gene (NK1R(-/-)) display behavioural abnormalities which resemble the hyperactivity, inattention and impulsivity seen in Attention Deficit Hyperactivity Disorder (ADHD). Here, we investigated whether the established ADHD treatment, atomox... | This evidence that atomoxetine reduces hyperactive/impulsive behaviours in NK1R(-/-) mice consolidates the validity of using NK1R(-/-) mice in research of the aetiology and treatment of ADHD. | yes |
25,432,775 | Do pre-treatment serum total bilirubin level as an indicator of optimal CPT-11 dosage? | {
"contexts": [
"Irinotecan (CPT-11), a highly effective chemotherapeutic agent, can cause severe neutropenia and diarrhea. The area under the curve of plasma levels over time of SN-38, an active metabolite of CPT-11, was previously reported to correlate with the pre-treatment serum total bilirubin level (PTB). H... | PTB can be used as a predictive marker of CPT-11-induced severe neutropenia and FN. In patients with PTB ≥0.8 mg/dL, the CPT-11 dose should be reduced to less than 80 mg/m(2) with weekly dosing. | yes |
25,443,620 | Does the indole derivative NecroX-7 improve nonalcoholic steatohepatitis in ob/ob mice through suppression of mitochondrial ROS/RNS and inflammation? | {
"contexts": [
"Nonalcoholic steatohepatitis (NASH) is associated with cirrhosis and hepatocellular carcinoma. Reactive oxygen species (ROS) and reactive nitrogen species (RNS) play key roles in the development of the disease. However, the therapeutic target of NASH has not been fully defined and new treatments ... | NecroX-7 treatment improved hepatic steatosis and fibrosis in murine NASH models. These effects occurred through the suppression of whole-cell ROS/RNS and inflammatory responses and suggest that NecroX-7 has a potential therapeutic benefit in steatohepatitis. | yes |
25,451,268 | Does fluorescent labelling of intestinal epithelial cells reveal independent long-lived intestinal stem cells in a crypt? | {
"contexts": [
"The dynamics of intestinal stem cells are crucial for regulation of intestinal function and maintenance. Although crypt stem cells have been identified in the intestine by genetic marking methods, identification of plural crypt stem cells has not yet been achieved as they are visualised in the sa... | The use of our original lentiviral transgene system to mark individual organoid crypt stem cells showed that long-lived plural crypt stem cells might independently serve as intestinal epithelial cells, resulting in the formation of a completely functional villus. | yes |
25,423,126 | Does noble-Collip Drum Trauma induce Disseminated Intravascular Coagulation But Not Acute Coagulopathy of Trauma-Shock? | {
"contexts": [
"There are two opposing possibilities for the main pathogenesis of trauma-induced coagulopathy: an acute coagulopathy of trauma shock and disseminated intravascular coagulation with the fibrinolytic phenotype.",
"The objective of this study was to clarify the main pathogenesis of trauma-induce... | The systemic thrombin generation accelerated by insufficient antithrombin control leads to the consumption of platelets and coagulation factors associated with hyperfibrin(ogen)olysis. These changes are collectively termed disseminated intravascular coagulation with the fibrinolytic phenotype. | yes |
25,445,437 | Does aminoguanidine inhibit ventricular fibrosis and remodeling process in isoproterenol-induced hypertrophied rat hearts by suppressing ROS and MMPs? | {
"contexts": [
"Aminoguanidine (AG), a well known inhibitor of advanced glycation end products, has been reported to attenuate cardiac hypertrophy and fibrosis. However, the underlying mechanism by which AG exerts its anti-fibrotic activity is not well understood. Reactive oxygen species (ROS) and matrix metallo... | Anti-fibrotic and anti-hypertrophic activities of AG were mainly attributed to its ROS quenching efficacy and its direct interaction with MMP-2 and MMP-9. | yes |
25,433,691 | Is biliary-enteric reconstruction with hepaticoduodenostomy following laparoscopic excision of choledochal cyst associated with better postoperative outcomes : a single-centre experience? | {
"contexts": [
"With the advent of laparoscopic surgery, more choledochal cysts are excised laparoscopically. In this study, we compared the outcomes from laparoscopic hepaticojejunostomy (HJ) and hepaticoduodenostomy (HD) for biliary-enteric reconstruction.",
"A retrospective analysis of patients who had un... | Laparoscopic excision of choledochal cyst with hepaticoduodenostomy reconstruction is safe and feasible with shorter operative time, ICU stay and overall hospital stay. It is not inferior to HJ in terms of short-term postoperative outcomes. | yes |
25,445,003 | Do international observational study of nutritional support in mechanically ventilated patients following burn injury? | {
"contexts": [
"It has been proposed that nutritional therapy in critically ill patients after major burn reduces mortality. However, the actual practice of nutrient delivery, and the effect on outcome, has not been described.",
"To evaluate international practices related to nutritional support and outcomes... | Mechanically ventilated patients following burn develop substantial energy and protein deficits, with lesser deficits observed in survivors. | yes |
25,440,013 | Is rs2070424 of the SOD1 gene associated with risk of Alzheimer 's disease? | {
"contexts": [
"Oxidative stress plays an important role in Alzheimer's disease (AD) etiopathogenesis. There were several studies that showed impaired antioxidant defense system (ADS) enzymes expression or activity in AD patients. There are only few studies evaluating the importance of ADS gene single nucleotide... | rs2070424 polymorphism of the SOD1 gene is a risk factor for AD in Polish population. Allel G and genotype AG and GG are protective factors for AD. | yes |
25,422,241 | Is structural maintenance of chromosomes 4 a predictor of survival and a novel therapeutic target in colorectal cancer? | {
"contexts": [
"Structural maintenance of chromosomes 4 (SMC-4) is a chromosomal ATPase which plays an important role in regulate chromosome assembly and segregation. However, the role of SMC-4 in the incidence of malignancies, especially colorectal cancer is still poorly understood.",
"We here used quantita... | Our clinical and experimental data suggest that SMC-4 may contribute to the progression of colorectal carcinogenesis. Our study provides a new therapeutic target for colorectal cancer treatment. | yes |
25,428,542 | Is intermediate filament protein nestin expressed in developing meninges? | {
"contexts": [
"Nestin is a type VI intermediate filament protein known as a marker for progenitor cells that can be mostly found in tissues during the embryonic and fetal periods. In our study, we aimed to determine the expression of nestin in meninges covering the brain tissue at different developmental stages... | In the present study, nestin positive cells gradually diminished in the developing and maturing meninges during the fetal period. This probably depends on initiation of a decrease in nestin expression and replacement with other tissue-specific intermediate filaments while the differentiation process continues. These di... | yes |
25,443,939 | Is dorsal plication without degloving safe and effective for correcting ventral penile deformities? | {
"contexts": [
"To compare the safety and efficacy of patients undergoing dorsal penile plication with patients undergoing ventral and lateral plication.",
"A retrospective review was performed of all patients who underwent penile plication between 2007 and 2013. Plication was performed through a 2-cm longit... | Penile plication is a safe and effective technique for correcting all directions of curvature. Dorsal plication without degloving produces favorable objective and subjective results comparable to ventral and lateral plication. | yes |
25,425,494 | Is work disability related to the presence of arthritis and not to a specific diagnosis . Results from a large early arthritis cohort in Argentina? | {
"contexts": [
"The objective of the study was to evaluate work disability and its main associated factors in patients with early arthritis. Argentine Consortium for Early Arthritis (CONAART) is the first early arthritis cohort in Argentina. Patients with one or more swollen joints and less than 2 years of sympt... | 1. Work disability is higher in patients with inflammatory arthritis as compared to the general population. 2. Prevalence of work disability is comparable among patients with undifferentiated and rheumatoid arthritis. 3. Disease activity is the main disease variable associated with work disability. | yes |
25,442,495 | Is the highly prevalent H3F3A mutation in giant cell tumours of bone shared by sporadic central giant cell lesion of the jaws? | {
"contexts": [
"Central giant cell lesion (CGCL) and giant cell tumour (GCT) are bone lesions that share similar microscopic features. Recently, it was reported that 90% of bone GCT exhibit either p.Gly34 Trp or p.Gly34 Leu in H3F3A, one of two genes for histone H3.3 located on chromosome 1. We aimed to test whe... | On the basis of our findings, H3F3A p.Gly34 Trp or p.Gly34 Leu mutations are not a frequent event in CGCL. If these alterations are confirmed to be exclusive of GCT, the assessment of H3F3A mutations may help in the differential diagnosis of GCT and CGCL of the jaws. | no |
25,449,047 | Is chronic thromboembolic pulmonary hypertension associated with iron overload? | {
"contexts": [
"Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized as the incomplete resolution of emboli after pulmonary embolism (PE) and the subsequent fibrotic organization and remodeling of pulmonary vascular bed. It has been reported that abnormal fibrin probably contributes to the inco... | CTEPH has no association with iron overload. The iron status evaluated by sTfR and ferritin is within the normal limits in this CTEPH population. | no |
25,429,844 | Does immunological profiling in chronic rhinosinusitis with nasal polyps reveal distinct VEGF and GM-CSF signatures during symptomatic exacerbations? | {
"contexts": [
"The mechanisms and immune pathways associated with chronic rhinosinusitis (CRS) are not fully understood. Immunological changes during acute exacerbation of CRS may provide valuable clues to the pathogenesis and perpetuation of the disease.",
"To characterize local and systemic immune respons... | CRSwNP patients demonstrate distinct immunological changes locally and systemically during acute exacerbation. Growth factors VEGF and GM-CSF may be involved in the immunopathogenesis of subjects with CRS and nasal polyps experiencing exacerbation. | yes |
25,424,745 | Do adolescents and young adults with type 1 diabetes display a high prevalence of endothelial dysfunction? | {
"contexts": [
"Little is known about endothelial function in adolescents with type 1 diabetes, and we evaluated endothelial dysfunction, using reactive hyperaemia peripheral arterial tonometry (RH-PAT).",
"This prospective, observational, 1-year study focused on 73 adolescents with type 1 diabetes, using mu... | Adolescents with type 1 diabetes displayed evidence of endothelial dysfunction. Good metabolic control (glycated haemoglobin ≤7.5%, 58 mmol/mol) and regular physical activity of at least 4 h a week might be protective. | yes |
25,441,375 | Do azo pigments and quinacridones induce delayed hypersensitivity in red tattoos? | {
"contexts": [
"Induction of delayed hypersensitivity reactions by red tattoos has been occasionally reported. Little is known about the inks used. Azo pigments have been implicated in some instances, but there is only one reported case involving quinacridones.",
"To describe the clinical and pathological fe... | Azo pigments and quinacridones both triggered reactions with similar clinical aspects but with varying histological findings. Patch and prick test results were disappointing with both. Reactions occurred following laser use in 1 case. | yes |
25,442,991 | Is neoadjuvant treatment response in negative nodes an important prognosticator after esophagectomy? | {
"contexts": [
"The current American Joint Committee on Cancer Seventh Edition (AJCC7) pathologic staging for esophageal adenocarcinoma (EAC) is derived from data assessing the outcomes of patients having undergone esophagectomy without neoadjuvant treatment and has unclear significance in patients who have rece... | Treatment-response lymph nodes detected from esophagectomy specimens in patients having undergone neoadjuvant chemotherapy or combined chemoradiation for EAC provide valuable prognostic information, particularly in patients with limited nodal disease. The current practice of considering lymph nodes lacking viable cance... | yes |
25,442,996 | Do adult aortic valve interstitial cells have greater responses to toll-like receptor 4 stimulation? | {
"contexts": [
"Aortic valve interstitial cells (AVICs) have been implicated in the pathogenesis of calcific aortic valve disease. Signal transducer and activator of transcription 3 (Stat3) possesses antiinflammatory effects. Given that calcification occurs in adult valves, we hypothesized that AVICs from adult ... | Adult AVICs exhibit greater inflammatory and osteogenic responses to TLR4 stimulation. The enhanced responses in adult AVICs are at least partly due to lower levels of Stat3 activation in response to TLR4 stimulation relative to pediatric cells. Stat3 functions as a negative regulator of the TLR4 responses in human AVI... | yes |
25,434,027 | Do pollen tube cell walls of wild and domesticated tomatoes contain arabinosylated and fucosylated xyloglucan? | {
"contexts": [
"In flowering plants, fertilization relies on the delivery of the sperm cells carried by the pollen tube to the ovule. During the tip growth of the pollen tube, proper assembly of the cell wall polymers is required to maintain the mechanical properties of the cell wall. Xyloglucan (XyG) is a cell ... | The results clearly indicate that the male gametophyte (pollen tube) and the sporophyte have structurally different XyG. This suggests that fucosylated XyG may have an important role in the tip growth of pollen tubes, and that they must have a specific set of functional XyG fucosyltransferases, which are yet to be char... | yes |
25,445,774 | Do clinical events after cessation of lamivudine therapy in patients recovered from hepatitis B flare with hepatic decompensation? | {
"contexts": [
"Before guidelines were issued, many patients with hepatitis B flare and hepatic decompensation had discontinued lamivudine therapy instead of indefinite therapy. We investigated their outcomes.",
"We performed a retrospective cohort study of 263 consecutive patients with chronic hepatitis B (... | Cessation of lamivudine therapy after recovery from hepatitis B flare with decompensation was safe for most patients. However, 8.2% develop decompensation within 1 year and can be rescued by timely retreatment. With close monitoring, the stopping strategy could be a feasible alternative to indefinite therapy, especiall... | yes |
25,427,583 | Is miRNA-205 a candidate tumor suppressor that targets ZEB2 in renal cell carcinoma? | {
"contexts": [
"This study aims to characterize the function of downregulated MicroRNA miR-205 in renal cell carcinoma (RCC), and show how the downstream zinc finger E-box-binding homeobox 2 (ZEB2) is negatively regulated by miR-205.",
"The expression of miR-205 was detected in RCC and adjacent non-tumor tis... | miR-205 is a candidate tumor suppressor that targets ZEB2 in RCC. | yes |
25,427,582 | Does the functional SNP rs3746804 in C20orf54 modify susceptibility to esophageal squamous cell carcinoma? | {
"contexts": [
"The aim of the present study was to explore the association of the functional single-nucleotide polymorphism (SNP) rs3746804 in C20orf54 with the susceptibility to esophageal squamous cell carcinoma (ESCC).",
"SNP rs3746804 in C20orf54 was detected by direct sequencing in 434 ESCC patients an... | A close association exists between functional SNP rs3746804 in C20orf54 and susceptibility to ESCC. | yes |
25,446,808 | Does soluble CD30 predict late acute rejection or safe tapering of immunosuppression in renal transplantation? | {
"contexts": [
"Previous reports revealed the potential value of the soluble CD30 level (sCD30) as biomarker for the risk of acute rejection and graft failure after renal transplantation, here we examined its use for the prediction of safe tapering of calcineurin inhibitors as well as late acute rejection.",
... | In two prospectively followed cohorts of renal transplant patients we found no association between sCD30 and the occurrence of either late acute rejection or acute rejection after reduction of immunosuppression. | no |
25,427,271 | Is generalized , severe , chronic periodontitis associated with anemia of chronic disease : a pilot study in urban , Indian males? | {
"contexts": [
"Anemia of chronic disease, a cytokine-mediated anemia, is a frequent complication of many chronic inflammatory conditions. The present case-control study was aimed to evaluate levels of systemic hematological markers indicative of anemia in patients with generalized, severe, chronic periodontitis... | Severe periodontal disease can be linked with anemic status. | yes |
25,427,270 | Does progressive periodontal disease have a simultaneous incremental elevation of gingival crevicular fluid and serum CRP levels? | {
"contexts": [
"Increased C-reactive protein levels have been found in all active inflammations, including periodontitis. This study aims to assess the C-reactive protein levels in periodontal disease progression.",
"Forty-five patients were divided into the following three groups (n=15) based on gingival in... | C-reactive protein levels in gingival crevicular fluid and serum increased proportionately with the severity of periodontal disease. They correlated positively with clinical parameters, including gingival index, probing pocket depth, and clinical attachment level. Thus, it can be considered as a periodontal inflammator... | yes |
25,433,903 | Is the anterior cingulate cortex a critical hub for pain-induced depression? | {
"contexts": [
"Besides chronic stress, chronic pain is a prevalent determinant for depression. Changes induced in specific brain regions by sustained pain may alter the processing of affective information, thus resulting in anxiodepressive disorders. Here, we compared the role of the anterior cingulate cortex (... | Our results show that, at cortical level, the sensory component of chronic pain remains functionally segregated from its affective and anxiodepressive components. Spontaneous tonic pain and evoked allodynia can be experimentally dissociated. Furthermore, the ACC appears as a critical hub for mood disorders, including f... | yes |
25,427,660 | Is the low level of glucagon-like peptide-1 ( glp-1 ) a risk factor of type 2 diabetes mellitus? | {
"contexts": [
"Glucagon like peptide-1 (GLP-1), an incretin hormone, regulates glucose metabolism by inducing insulin secretion and suppressing glucagon secretion. The aim of the study is to assess the levels of fasting and post-prandial GLP-1 and their risk for T2DM. A case control study was conducted at the d... | From this study it can be concluded that levels of intact GLP-1 are an important risk factor for T2DM in the Indonesian population. | yes |
25,428,031 | Does shinzami Korean purple-fleshed sweet potato extract prevent ischaemia-reperfusion-induced liver damage in rats? | {
"contexts": [
"This study was designed to investigate the hepatoprotective effect of an extract from Shinzami, a variety of purple sweet potato, in rats injured by hepatic ischaemia-reperfusion (I/R).",
"Pretreatment with Shinzami extract decreased the aspirate aminotransferase and alanine aminotransferase ... | Shinzami extract and anthocyanins have a hepatoprotective effect on the liver damage induced by hepatic I/R by improving antioxidant status. Furthermore, the Shinzami extract may have a more potent effect on the antioxidant status compared with the Shinzami anthocyanins alone. | yes |
25,444,592 | Does vagus nerve stimulation have antidepressant effects in the kainic acid model for temporal lobe epilepsy? | {
"contexts": [
"Depression is the most common psychiatric comorbidity in epilepsy patients. The lack of success with current pharmacological interventions for this patient population, highlights the importance of optimizing non-pharmacological neuromodulatory treatments such as vagus nerve stimulation (VNS). Stu... | The KA rats displayed anhedonia which was significantly decreased by VNS, indicating that this neuromodulatory treatment could likewise diminish depressive symptoms in patients suffering from temporal lobe epilepsy and comorbid depression. | yes |
25,442,336 | Is epidermal growth factor receptor mutation associated with longer local control after definitive chemoradiotherapy in patients with stage III nonsquamous non-small-cell lung cancer? | {
"contexts": [
"To determine the frequency and clinical significance of epidermal growth factor receptor (EGFR) mutations in patients with potentially curable stage III non-small-cell lung cancer (NSCLC) who are eligible for definitive chemoradiotherapy (CRT).",
"Between January 2001 and December 2010, we an... | Our study is the first to show radiosensitive biology of EGFR-mutated tumors in definitive CRT with curative intent. This finding could serve as a credible baseline estimate of EGFR-mutated population in stage III nonsquamous NSCLC. | yes |
25,428,923 | Is epidemic MRSA clone ST22-IV more resistant to multiple host- and environment-related stresses compared with ST228-I? | {
"contexts": [
"ST22-IV is a successful hospital-associated MRSA clone. Due to its known ability to replace other MRSA clones in hospitals, it became a dominant clone in Europe and beyond. So far, there are no studies investigating the relationship between the epidemiological success of MRSA clones and their cap... | Our results support our hypothesis that ST22-IV has a fitness advantage over ST228-I. This fitness advantage could have allowed ST22-IV to displace ST228-I without acquiring additional resistances and could help explain its epidemic success in hospital settings and its spread in Europe and beyond. | yes |
25,428,920 | Is virological failure after 1 year of first-line ART associated with HIV minority drug resistance in rural Cameroon? | {
"contexts": [
"The aim of this study was to describe clinical and virological outcomes in therapy-naive HIV-1-positive patients treated in a routine ART programme in rural Cameroon.",
"In a prospective cohort, 300 consecutive patients starting first-line ART were enrolled and followed for 12 months. Among 2... | Virological failure after 1 year of ART was not associated with minority drug resistance at baseline but with incomplete adherence. Strategies to assure adherence and uninterrupted drug supplies are pivotal factors for therapy success. | no |
25,446,481 | Is blood transfusion associated with recurrence of hepatocellular carcinoma after hepatectomy in Child-Pugh class A patients? | {
"contexts": [
"Previous reports have indicated an association between blood transfusion and prognosis of hepatocellular carcinoma (HCC) after hepatectomy. However, clinicopathological biases were not adjusted in these studies. We aimed to clarify the effect of blood transfusions in patients with HCC and Child-P... | These results suggest that blood transfusion was associated with recurrence of HCC after hepatectomy in patients with HCC and Child-Pugh class A. | yes |
25,431,933 | Does transcutaneous oxygen tension measurements following peripheral transluminal angioplasty procedure have more specificity and sensitivity than ankle brachial index? | {
"contexts": [
"To evaluate the superiority of transcutaneous oxygen pressure (TcPO2) before, during and after peripheral transluminal angioplasty (PTA) in comparison with ankle brachial index (ABI) in patients with diabetes.",
"40 consecutive patients with diabetes treated by PTA where included. This study ... | The increase in TcPO2 measurements following PTA procedure has more specificity and sensitivity than does ABI. The use of TcPO2 may represent a more accurate alternative than traditional methods (ABI) used in assessing PTA results. The TcPO2 also allows the radiologist to assess changes in tissue oxygenation during PTA... | yes |
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