journal stringlengths 3 239 | meshMajor listlengths 1 47 | year int64 2.02k 2.02k | abstractText stringlengths 1 31.2k | pmid stringlengths 8 8 | title stringlengths 0 1.06k |
|---|---|---|---|---|---|
The American journal of emergency medicine | [
"Acute Kidney Injury",
"Adult",
"Aged",
"Biomarkers",
"Creatine",
"Creatine Kinase",
"Emergency Service, Hospital",
"Female",
"Fluid Therapy",
"Humans",
"Length of Stay",
"Male",
"Middle Aged",
"Retrospective Studies",
"Rhabdomyolysis",
"Young Adult"
] | 2,019 | OBJECTIVE: To evaluate the occurrence of renal injury in hospitalized patients with the diagnosis of rhabdomyolysis among a series of patients presenting to an urban emergency department.METHODS: A retrospective chart review between January 2006 and February 2017 was conducted on patients aged 21-65 years old that were... | 30902360 | Rhabdomyolysis - Go big or go home. |
Food research international (Ottawa, Ont.) | [
"Animals",
"Bacteria",
"Cooking",
"Dietary Proteins",
"Digestion",
"Fatty Acids",
"Food Microbiology",
"Hot Temperature",
"Humans",
"Insect Proteins",
"Nutritive Value",
"Tenebrio"
] | 2,018 | Mealworms are new food products in Europe, but consumers do not know how to cook them. Although cooking could increase the safety, acceptability, palatability, and digestibility of insects, the heating process could have deleterious effects on protein and lipid quality. Therefore, this study characterized the effects o... | 29579954 | Effect of household cooking techniques on the microbiological load and the nutritional quality of mealworms (Tenebrio molitor L. 1758). |
Prenatal diagnosis | [
"DNA",
"Decision Making",
"Down Syndrome",
"Female",
"Genetic Diseases, Inborn",
"Genetic Testing",
"Humans",
"Newspapers as Topic",
"Pregnancy",
"Prenatal Diagnosis",
"Sex Determination Analysis",
"United Kingdom"
] | 2,015 | OBJECTIVE: To investigate how non-invasive prenatal testing (NIPT) is portrayed in the UK press media.METHODS: Content analysis of the ten most widely circulated print/digital news sources in the UK.RESULTS: Seventy-nine articles were identified focusing on NIPT for Down syndrome (n = 67) including single gene disorder... | 25233815 | 'Hope for safe prenatal gene tests'. A content analysis of how the UK press media are reporting advances in non-invasive prenatal testing. |
International journal of clinical and experimental pathology | [
"Adult",
"Aged",
"Asians",
"Colorectal Neoplasms",
"Female",
"Genetic Predisposition to Disease",
"Genotype",
"Glucuronidase",
"Humans",
"Klotho Proteins",
"Linkage Disequilibrium",
"Male",
"Middle Aged",
"Polymerase Chain Reaction",
"Polymorphism, Restriction Fragment Length",
"Polymo... | 2,015 | AIM: The purpose of this study was to investigate the relationship of Klotho gene G-395A and C1818T polymorphisms with colorectal cancer (CRC) susceptibility.METHODS: 125 CRC patients and 125 controls were enrolled in the study. G-395A and C1818T polymorphisms were genotyped with polymerase chain reaction-restriction f... | 26261651 | Klotho gene polymorphisms are related to colorectal cancer susceptibility. |
British journal of cancer | [
"Adult",
"Aged",
"Aged, 80 and over",
"Antineoplastic Agents",
"Carcinoma",
"Chemotherapy, Adjuvant",
"Cohort Studies",
"Female",
"Humans",
"Lymphocytes, Tumor-Infiltrating",
"Middle Aged",
"Neoadjuvant Therapy",
"Retrospective Studies",
"Tumor Microenvironment",
"Uterine Cervical Neopla... | 2,021 | BACKGROUND: We aimed to comprehensively evaluate the immunologic landscape at baseline and upon chemotherapy in cervical cancer. The information should aid ongoing clinical investigations of checkpoint blockade immunotherapies in this disease setting.METHODS: A series of 109 cervical carcinoma patients was retrospectiv... | 33087896 | Baseline immunity and impact of chemotherapy on immune microenvironment in cervical cancer. |
Tissue engineering. Part A | [
"Animals",
"Disease Models, Animal",
"Gene Transfer Techniques",
"HEK293 Cells",
"Humans",
"Luciferases",
"Mice",
"Myocardial Infarction",
"Myocytes, Cardiac",
"RNA, Messenger",
"Swine"
] | 2,019 | IMPACT STATEMENT: The M3RNA (microencapsulated modified messenger RNA) platform is an approach to deliver messenger RNA (mRNA) in vivo, achieving a nonintegrating and viral-free approach to gene therapy. This technology was, in this study, tested for its utility in the myocardium, providing a unique avenue for targeted... | 30047313 | M3RNA Drives Targeted Gene Delivery in Acute Myocardial Infarction. |
World neurosurgery | [
"Brain Stem Neoplasms",
"Endoscopy",
"Hemangioma, Cavernous, Central Nervous System",
"Humans",
"Neurosurgical Procedures",
"Treatment Outcome"
] | 2,021 | Surgical treatment of brainstem cavernoma is controversial.1 With modern surgical technique, safe and complete removal of selected brainstem cavernoma is possible.2 The choice of optimal corridor must consider various factors, including eloquent structures of the brainstem, cavernoma shape and location, as well as the ... | 33753321 | Endoscopic Endonasal Resection of a Pontine Brainstem Cavernoma. |
Virus genes | [
"Animals",
"Base Sequence",
"Chickens",
"China",
"Coronavirus Infections",
"Genome, Viral",
"Genotype",
"Infectious bronchitis virus",
"Mutation",
"Phylogeny",
"Poultry Diseases",
"Recombination, Genetic",
"Sequence Analysis, DNA",
"Vaccines, Attenuated",
"Virulence"
] | 2,016 | Recombination between infectious bronchitis viruses (IBVs), together with point mutations, insertions, and deletions, is thought to be responsible for the emergence of new IBV variants. SAIBK2 is a nephropathogenic strain isolated from layer flocks vaccinated with live attenuated H120 vaccine in Sichuan province, China... | 27108998 | Genome sequence and origin analyses of the recombinant novel IBV virulent isolate SAIBK2. |
Communications biology | [
"Biomarkers",
"Brain",
"Cerebrovascular Circulation",
"Electroencephalography",
"Humans",
"Image Interpretation, Computer-Assisted",
"Image Processing, Computer-Assisted",
"Magnetic Resonance Imaging",
"Oxygen",
"Sympathetic Nervous System"
] | 2,019 | The interpretation of functional magnetic resonance imaging (fMRI) studies of brain activity is often hampered by the presence of brain-wide signal variations that may arise from a variety of neuronal and non-neuronal sources. Recent work suggests a contribution from the sympathetic vascular innervation, which may affe... | 31754651 | Sympathetic activity contributes to the fMRI signal. |
Methods in molecular biology (Clifton, N.J.) | [
"Anti-Bacterial Agents",
"Bacterial Proteins",
"Biofilms",
"Cyclic GMP",
"Gene Expression",
"Gene Expression Regulation, Bacterial",
"Genes, Reporter",
"Genetic Testing",
"Luminescent Measurements",
"Plasmids",
"Promoter Regions, Genetic",
"Pseudomonas aeruginosa",
"Signal Transduction"
] | 2,017 | Pseudomonas aeruginosa infections are often difficult or impossible to treat, mainly due to its ability to form antibiotic-resistant biofilms. Since c-di-GMP signaling strongly influences P. aeruginosa biofilm development and sensitivity to antibiotics, it is considered a promising target for the development of anti-bi... | 28889314 | Genetic Tools to Study c-di-GMP-Dependent Signaling in Pseudomonas aeruginosa. |
Cell death and differentiation | [
"Acetylation",
"Antineoplastic Agents",
"Apoptosis",
"Caspase 3",
"Caspase 7",
"Cell Line, Tumor",
"Drug Resistance, Neoplasm",
"Drug Synergism",
"Genome, Human",
"HCT116 Cells",
"Histone Deacetylase Inhibitors",
"Histones",
"Humans",
"Hydroxamic Acids",
"Proto-Oncogene Proteins c-bcl-2"... | 2,016 | Vorinostat is an FDA-approved histone deacetylase inhibitor (HDACi) that has proven clinical success in some patients; however, it remains unclear why certain patients remain unresponsive to this agent and other HDACis. Constitutive STAT (signal transducer and activator of transcription) activation, overexpression of p... | 26868908 | A genome scale RNAi screen identifies GLI1 as a novel gene regulating vorinostat sensitivity. |
Journal of Crohn's & colitis | [
"Acetic Acid",
"Aminopyridines",
"Animals",
"Colitis",
"Disease Models, Animal",
"Intestinal Mucosa",
"Intracellular Signaling Peptides and Proteins",
"Male",
"Morpholines",
"Oxazines",
"Protein-Tyrosine Kinases",
"Pyridines",
"Pyrimidines",
"Rats",
"Rats, Sprague-Dawley",
"Syk Kinase"... | 2,015 | BACKGROUND AND AIMS: Inflammatory bowel disease is a chronic inflammatory disease of the gastrointestinal system. In some cases, current medications used for inflammatory bowel disease may not be enough for remission, creating a need for more potent and reliable medications. There is no study showing the efficacy of fo... | 26116555 | The Syk Inhibitor Fostamatinib Decreases the Severity of Colonic Mucosal Damage in a Rodent Model of Colitis. |
Pediatric neurology | [
"Brain",
"Brain Mapping",
"Cross-Sectional Studies",
"Female",
"Humans",
"Image Processing, Computer-Assisted",
"Infant",
"Infant, Extremely Premature",
"Longitudinal Studies",
"Magnetic Resonance Imaging",
"Male",
"Neural Pathways",
"Organ Size",
"Pattern Recognition, Automated",
"Rest"... | 2,015 | BACKGROUND: Diffuse white matter abnormalities are identified in up to 80% of very preterm infants on magnetic resonance imaging at 40 weeks' postmenstrual age. Several studies have observed an association between diffuse white matter abnormalities and cognitive deficits. We hypothesized that very preterm infants (gest... | 26216502 | Aberrant Executive and Frontoparietal Functional Connectivity in Very Preterm Infants With Diffuse White Matter Abnormalities. |
Journal of environmental radioactivity | [
"Adsorption",
"Aluminum Silicates",
"Groundwater",
"Hydrogen-Ion Concentration",
"Minerals",
"Soil",
"Soil Pollutants, Radioactive",
"Spectrum Analysis",
"Uranium"
] | 2,019 | This research studied the sorption behavior of uranium(VI) onto two different kinds of soils: surface soil and undersurface soil that taken from the depth of 30 m undersurface. The soil samples were collected from a low and medium-level radioactive waste disposal site in the southwest of China. The effects of pH, solid... | 30921606 | Sorption of U(VI) onto natural soils and different mineral compositions: The batch method and spectroscopy analysis. |
Journal of neuroinflammation | [
"Aging",
"Animals",
"Antiparkinson Agents",
"Brain",
"Calcium-Binding Proteins",
"Cognition Disorders",
"Cytokines",
"Dose-Response Relationship, Drug",
"Exploratory Behavior",
"Gene Expression",
"Histocompatibility Antigens",
"Inflammation",
"Male",
"Maze Learning",
"Microfilament Prote... | 2,016 | BACKGROUND: Clinical studies have shown an association between long-term anticholinergic (AC) drug exposure and Alzheimer's disease (AD) pathogenesis, which has been primarily investigated in Parkinson's disease (PD). However, long-term AC exposure as a risk factor for developing neurodegenerative disorders and the exa... | 27411393 | Long-term trihexyphenidyl exposure alters neuroimmune response and inflammation in aging rat: relevance to age and Alzheimer's disease. |
La Revue de medecine interne | [
"Adrenal Gland Diseases",
"Adrenal Glands",
"Antiphospholipid Syndrome",
"Hemorrhage",
"Humans",
"Male",
"Middle Aged",
"Necrosis",
"Pyrazoles",
"Pyridones",
"Venous Thromboembolism"
] | 2,020 | INTRODUCTION: Adrenal hemorrhage is a classical but rare complication of antiphospholipid syndrome, revealing diagnosis in one third of the cases. Anti-vitamin K therapy is the standard treatment but direct oral anticoagulants are discussed as an alternative. In the latest recommendations, it is advised not to use dire... | 31672255 | [Bilateral adrenal hemorrhage under apixaban in primary antiphospholipid syndrome]. |
Nederlands tijdschrift voor geneeskunde | [
"Colitis, Ulcerative",
"Humans",
"Leukopenia",
"Male",
"Mercaptopurine",
"Middle Aged",
"Pancytopenia",
"Thioguanine"
] | 2,018 | Thiopurine drugs, such as thioguanine, mercaptopurine and azathioprine, are used for treating inflammatory bowel disease, such as ulcerative colitis. One must be aware of the serious side effects these drugs can have (e.g. bone marrow depression). A 56-year-old man with ulcerative colitis was treated with mercaptopurin... | 30379500 | [Pancytopenia associated with thioguanine use]. |
Protein science : a publication of the Protein Society | [
"Base Sequence",
"Binding Sites",
"Crystallography, X-Ray",
"DNA",
"DNA-Binding Proteins",
"GATA1 Transcription Factor",
"LIM Domain Proteins",
"Models, Biological",
"Transcription Factors"
] | 2,015 | The transcription factor GATA1 helps regulate the expression of thousands of genes involved in blood development, by binding to single or double GATA sites on DNA. An important part of gene activation is chromatin looping, the bringing together of DNA elements that lie up to many thousands of basepairs apart in the gen... | 26234528 | GATA1 directly mediates interactions with closely spaced pseudopalindromic but not distantly spaced double GATA sites on DNA. |
Breastfeeding medicine : the official journal of the Academy of Breastfeeding Medicine | [
"3-Hydroxybutyric Acid",
"Austria",
"Diet, Ketogenic",
"Epilepsy",
"Feasibility Studies",
"Female",
"Humans",
"Infant",
"Male",
"Milk, Human",
"Retrospective Studies"
] | 2,020 | Objective: The ketogenic diet (KD) is a high-fat and restricted carbohydrate diet for treating severe childhood epilepsy. In infants, breast milk is usually fully replaced by a ketogenic formula. At our center, mothers are encouraged to include breastfeeding into the KD if still breastfeeding. This retrospective study ... | 31770024 | The Ketogenic Diet Including Breast Milk for Treatment of Infants with Severe Childhood Epilepsy: Feasibility, Safety, and Effectiveness. |
Investigative radiology | [
"Adult",
"Aged",
"Aged, 80 and over",
"Blood Flow Velocity",
"Computer Simulation",
"Contrast Media",
"Female",
"Gadolinium DTPA",
"Humans",
"Image Interpretation, Computer-Assisted",
"Liver",
"Liver Circulation",
"Liver Cirrhosis",
"Liver Function Tests",
"Magnetic Resonance Angiography... | 2,015 | OBJECTIVE: The purpose of this study was to estimate perfusion metrics in healthy and cirrhotic liver with pharmacokinetic modeling of high-temporal resolution reconstruction of continuously acquired free-breathing gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced acquisition in patients undergoing c... | 25333309 | Estimating liver perfusion from free-breathing continuously acquired dynamic gadolinium-ethoxybenzyl-diethylenetriamine pentaacetic acid-enhanced acquisition with compressed sensing reconstruction. |
The Pan African medical journal | [
"Adult",
"Anti-HIV Agents",
"Cross-Sectional Studies",
"Education, Nursing, Continuing",
"Female",
"HIV Infections",
"Health Facilities",
"Humans",
"Implementation Science",
"Infant, Newborn",
"Infant, Newborn, Diseases",
"Infectious Disease Transmission, Vertical",
"Mass Screening",
"Ment... | 2,020 | This was a cross-sectional study describing HIV testing uptake and ART initiation for pregnant women and HIV-exposed infants after one-off clinical mentorship training in 2013 for nurses in 56 peripheral health-facilities, Zimbabwe. Between 2014-2018, 92% of 106411 pregnant women were HIV tested and 98% of HIV-positive... | 32874410 | Prevention of mother-to-child transmission activities after one-off clinical mentorship training in selected health facilities, Zimbabwe: 2014-2018. |
The Journal of urology | [
"Adult",
"Aged",
"Certification",
"Female",
"Humans",
"Male",
"Middle Aged",
"North America",
"Practice Patterns, Physicians'",
"Societies, Medical",
"Surgeons",
"Surgical Oncology",
"Urologic Surgical Procedures",
"Urologists"
] | 2,017 | PURPOSE: Objective data on patterns of oncology practice among pediatric urologists are lacking. We reviewed surgical case logs submitted to the American Board of Urology by those self-reporting as pediatric urologists. We hypothesized that logs would reveal a low oncology volume (fewer than 5 cases) and identify orchi... | 27986529 | Patterns of Performance of Oncologic Surgery by North American Pediatric Urologists: A Report from the Pediatric Urologic Oncology Working Group of the Society for Pediatric Urology. |
Methods in molecular biology (Clifton, N.J.) | [
"Actins",
"Animals",
"Biomarkers",
"CCN Intercellular Signaling Proteins",
"Chromatin Immunoprecipitation",
"Collagen Type I",
"Connective Tissue Growth Factor",
"Disease Models, Animal",
"Enzyme-Linked Immunosorbent Assay",
"Gene Expression",
"Genes, Reporter",
"Hepatic Stellate Cells",
"Hu... | 2,017 | Hepatic fibrosis is a complex pathology arising from chronic injury. Pathological features are dominated by the excessive production of extracellular matrix proteins, particularly collagens which are deposited as insoluble scar material that can compromise tissue function. Fibrosis in the liver can often be assessed by... | 27734396 | Analysis of Pathological Activities of CCN Proteins in Fibrotic Diseases: Liver Fibrosis. |
Environmental science and pollution research international | [
"Air Pollutants",
"Air Pollution",
"Cardiovascular Diseases",
"Environmental Exposure",
"Humans",
"Incidence",
"Iran",
"Nitrogen Dioxide",
"Ozone",
"Particulate Matter",
"Risk Factors"
] | 2,017 | Air pollution is emerging as a risk factor for human health like cancer and other health outcomes in developing countries, especially Iran where air pollutant concentrations are elevated. Additionally, some of the crucial environmental problems are caused by air pollution. Nevertheless, the data on health effects of ai... | 27837472 | Exposure to PM10, NO2, and O3 and impacts on human health. |
Journal of hypertension | [
"Cardiac Imaging Techniques",
"Humans",
"Hypertension",
"Practice Guidelines as Topic",
"Risk",
"Societies, Medical"
] | 2,017 | : Arterial hypertension accounts for the largest amount of attributable cardiovascular mortality worldwide, and risk stratification in hypertensive patients is of crucial importance to manage treatment and prevent adverse events. Asymptomatic involvement of different organs in patients affected by hypertension represen... | 28767484 | Noninvasive cardiovascular imaging for evaluating subclinical target organ damage in hypertensive patients: a consensus article from the European Association of Cardiovascular Imaging, the European Society of Cardiology Council on Hypertension and the European Society of Hypertension. |
PLoS computational biology | [
"Adenine",
"Amino Acid Motifs",
"Binding Sites",
"Computational Biology",
"Computer Simulation",
"Databases, Protein",
"Glycine",
"Magnetic Resonance Spectroscopy",
"Methionine Adenosyltransferase",
"Molecular Dynamics Simulation",
"Principal Component Analysis",
"Protein Binding",
"Protein ... | 2,020 | S-adenosylmethionine (SAM) is one of the most important enzyme substrates. It is vital for the function of various proteins, including large group of methyltransferases (MTs). Intriguingly, some bacterial and eukaryotic MTs, while catalysing the same reaction, possess significantly different topologies, with the former... | 32453784 | Restriction of S-adenosylmethionine conformational freedom by knotted protein binding sites. |
Shanghai kou qiang yi xue = Shanghai journal of stomatology | [
"Animals",
"Cell Adhesion",
"Cell Line",
"Cell Proliferation",
"Gene Expression",
"Mice",
"Microscopy, Electron, Scanning",
"Osteoblasts",
"Osteogenesis",
"Oxidation-Reduction",
"Real-Time Polymerase Chain Reaction",
"Surface Properties",
"Titanium"
] | 2,015 | PURPOSE: This study was intended to modify the surface of pure titanium by micro-arc oxidation (MAO), and to investigate the effects of MAO process on the biological behavior of MC3T3-E1 osteoblastic cells.METHODS: MAO treatment of specimens were carried out using a staggered voltage boost procedure. The surface topogr... | 26598187 | [Effects of micro-arc oxidation on the biological behaviors of MC3T3-E1 cells on titanium]. |
Nature neuroscience | [
"Autism Spectrum Disorder",
"Gene Regulatory Networks",
"Humans",
"Induced Pluripotent Stem Cells",
"Inhibitory Postsynaptic Potentials",
"Nerve Net",
"Neural Stem Cells",
"Neurons"
] | 2,019 | Autism spectrum disorder (ASD) is thought to emerge during early cortical development. However, the exact developmental stages and associated molecular networks that prime disease propensity are elusive. To profile early neurodevelopmental alterations in ASD with macrocephaly, we monitored subject-derived induced pluri... | 30617258 | Pathological priming causes developmental gene network heterochronicity in autistic subject-derived neurons. |
Journal of diabetes investigation | [
"Adult",
"Amino Acids, Essential",
"Asians",
"Blood Glucose",
"Body Mass Index",
"China",
"Glucose Clamp Technique",
"Humans",
"India",
"Insulin",
"Insulin Resistance",
"Male",
"Muscle, Skeletal",
"Young Adult"
] | 2,018 | AIMS/INTRODUCTION: Indian individuals are more insulin resistant (IR) than Chinese individuals, even among those with a non-obese body mass index (BMI). However, BMI often underestimates body fat in Indian individuals, and it remains unclear whether Indians would remain more IR than Chinese individuals when both BMI an... | 29582571 | Comprehensive assessment of insulin resistance in non-obese Asian Indian and Chinese men. |
The Journal of psychology | [
"Academic Success",
"Adolescent",
"Adult",
"Attitude",
"Female",
"Humans",
"Intelligence",
"Male",
"Mexico",
"Personal Satisfaction",
"Students",
"Universities",
"Young Adult"
] | 2,019 | "Mindsets (or implicit theories) are people's lay beliefs about the nature of human attributes, such as intelligence or personality". Individuals with a fixed mindset believe that intelligence is an unchangeable trait, whereas those with a growth mindset think of it as a malleable quality that can be increased and deve... | 31314699 | Do Mindsets Shape Students' Well-Being and Performance? |
Applied physiology, nutrition, and metabolism = Physiologie appliquee, nutrition et metabolisme | [
"AMP-Activated Protein Kinases",
"Age Factors",
"Aminoimidazole Carboxamide",
"Animals",
"Enzyme Activation",
"Enzyme Activators",
"GTPase-Activating Proteins",
"Glucose",
"Glucose Transporter Type 4",
"Hexokinase",
"In Vitro Techniques",
"Insulin",
"Male",
"Muscle, Skeletal",
"Phosphory... | 2,018 | 5' AMP-activated protein kinase (AMPK) activation may be part of the exercise-induced process that enhances insulin sensitivity. Independent of exercise, acute prior treatment of skeletal muscles isolated from young rats with a pharmacological AMPK activator, 5-aminoimidazole-4-carboxamide-1-�-d-ribofuranoside (AICAR),... | 29518344 | Prior treatment with the AMPK activator AICAR induces subsequently enhanced glucose uptake in isolated skeletal muscles from 24-month-old rats. |
Chemosphere | [
"Anion Exchange Resins",
"Flocculation",
"Hydrophobic and Hydrophilic Interactions",
"Ion Exchange",
"Organic Chemicals",
"Water Pollutants, Chemical",
"Water Purification"
] | 2,020 | Three different source waters were investigated using virgin and pre-used anion exchange resins, coagulation, and ion exchange combined with coagulation (IEX&Coagulation). The hydrophobicity, size distribution and charge of natural organic matter (NOM) were used to evaluate its removal. Dissolved organic carbon (DOC) r... | 31454747 | The combined influence of hydrophobicity, charge and molecular weight on natural organic matter removal by ion exchange and coagulation. |
The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians | [
"Adult",
"Delivery, Obstetric",
"Female",
"Hong Kong",
"Humans",
"Infant, Newborn",
"Obstetrics and Gynecology Department, Hospital",
"Pregnancy",
"Pregnancy Outcome",
"Pregnancy, Twin",
"Retrospective Studies",
"Twins",
"Vagina"
] | 2,016 | OBJECTIVE: To determine any change in adverse neonatal/maternal outcomes after increasing the rate of vaginal twin delivery by comparing vaginal twin delivery and caesarean delivery with our previous cohort study.METHODS: In a retrospective cohort study, all twins booked at a Hong Kong regional obstetrics unit were eva... | 25893547 | Twin pregnancy outcomes after increasing rate of vaginal twin delivery: retrospective cohort study in a Hong Kong regional obstetric unit. |
The Journal of pediatrics | [
"Adolescent",
"Boston",
"Child",
"Child, Preschool",
"DNA Copy Number Variations",
"Developmental Disabilities",
"Female",
"Fetal Alcohol Spectrum Disorders",
"Genetic Testing",
"Humans",
"Infant",
"Infant, Newborn",
"Male",
"Pregnancy",
"Prenatal Exposure Delayed Effects",
"Retrospect... | 2,018 | OBJECTIVE: To study the utility of genetic evaluation and testing in patients with suspected fetal alcohol spectrum disorder (FASD).STUDY DESIGN: We performed a retrospective chart review of all patients (n = 36) referred for evaluation for suspected FASD to the genetics clinic at Boston Children's Hospital between Jan... | 29398060 | Utility of Genetic Testing in Fetal Alcohol Spectrum Disorder. |
International journal of molecular sciences | [
"Arabidopsis",
"Biosynthetic Pathways",
"Endosomes",
"Fatty Acids",
"Phosphatidylinositol Phosphates",
"Sphingolipids",
"trans-Golgi Network"
] | 2,021 | A main characteristic of sphingolipids is the presence of a very long chain fatty acid (VLCFA) whose function in cellular processes is not yet fully understood. VLCFAs of sphingolipids are involved in the intracellular traffic to the vacuole and the maturation of early endosomes into late endosomes is one of the major ... | 34445155 | Inhibition of Very Long Chain Fatty Acids Synthesis Mediates PI3P Homeostasis at Endosomal Compartments. |
Annals of vascular surgery | [
"Adult",
"Blood Vessel Prosthesis Implantation",
"Catheterization, Central Venous",
"Computed Tomography Angiography",
"Contrast Media",
"Endovascular Procedures",
"Female",
"Fluoroscopy",
"Humans",
"Iatrogenic Disease",
"Imaging, Three-Dimensional",
"Multidetector Computed Tomography",
"Pat... | 2,020 | CT angiography with multislice detector has become the preferred method for assessment of hemodynamically stable patients suspected of great vessel injury from iatrogenic and blunt trauma. The CT images obtained can be transformed into a three-dimensional (3D) model using the software within minutes. This allows the cl... | 31705991 | CT Three-Dimensional (3D) Modeling Maintains Fluoroscopy Time and Contrast Volume to a Minimum in the Endovascular Treatment of Great Vessel Injury from Iatrogenic Trauma. |
Clinical cancer research : an official journal of the American Association for Cancer Research | [
"Animals",
"Antineoplastic Agents",
"Apoptosis",
"Cell Line, Tumor",
"Cell Proliferation",
"Cell Survival",
"Colonic Neoplasms",
"Cryptoxanthins",
"DNA-Binding Proteins",
"Disease Models, Animal",
"Down-Regulation",
"Drug Synergism",
"Female",
"Gene Expression Regulation, Neoplastic",
"H... | 2,015 | BACKGROUND: The acquired resistance to chemotherapy represents the major limitation in the treatment of cancer. New strategies to solve this failure and improve patients' outcomes are necessary. The cancer preventive effect of �-cryptoxanthin has been widely described in population studies. Few reports support its puta... | 26023082 | �-Cryptoxanthin Synergistically Enhances the Antitumoral Activity of Oxaliplatin through �NP73 Negative Regulation in Colon Cancer. |
Academic medicine : journal of the Association of American Medical Colleges | [
"Certification",
"Education, Medical, Graduate",
"Humans",
"Licensure, Medical",
"Specialty Boards",
"State Government",
"United States"
] | 2,016 | Approaches to postgraduate medical training have evolved substantially in recent years, reflecting the complexity of the educational mission. Residency programs seek to produce clinicians who achieve board certification as an attestation of their competency. Certification criteria are established by the American Board ... | 26445079 | Is It Time to Rethink Postgraduate Training Requirements for Licensure? |
JACC. Cardiovascular interventions | [
"Aged",
"Angina Pectoris",
"Antigens, CD34",
"Biomarkers",
"Double-Blind Method",
"Early Termination of Clinical Trials",
"Endothelial Progenitor Cells",
"Exercise Tolerance",
"Female",
"Humans",
"Male",
"Middle Aged",
"Neovascularization, Physiologic",
"Recovery of Function",
"Risk Fact... | 2,016 | OBJECTIVES: This study tested whether intramyocardial (IM) administration of mobilized, purified autologous CD34(+) cells would improve total exercise time (TET) and angina frequency in patients with refractory angina.BACKGROUND: IM administration of autologous CD34(+) cells has been associated consistently with improv... | 27491607 | The RENEW Trial: Efficacy and Safety of Intramyocardial Autologous CD34(+) Cell Administration in Patients With Refractory Angina. |
Acta clinica Croatica | [
"Adolescent",
"Adult",
"Aged",
"Aged, 80 and over",
"Cross-Sectional Studies",
"Female",
"Food Hypersensitivity",
"Fruit",
"Humans",
"Male",
"Middle Aged",
"Prevalence",
"Rhinitis, Allergic, Seasonal",
"Risk Factors",
"Syndrome",
"Vegetables",
"Young Adult"
] | 2,015 | The aim of this study was to assess the prevalence of oral allergy syndrome (OAS) in patients with seasonal allergic rhinitis (SAR) and the possible risk factors for its development. This cross-sectional study was conducted in primary care offices in the Split-Dalmatia County during the period from March 1 to September... | 26058239 | Prevalence and risk factors for developing oral allergy syndrome in adult patients with seasonal allergic rhinitis. |
International journal of systematic and evolutionary microbiology | [
"Acetophenones",
"Bacillaceae",
"Bacterial Typing Techniques",
"Base Composition",
"Cell Wall",
"DNA, Bacterial",
"Fatty Acids",
"Glycolipids",
"Molecular Sequence Data",
"Nucleic Acid Hybridization",
"Peptidoglycan",
"Phospholipids",
"Phylogeny",
"RNA, Ribosomal, 16S",
"Sequence Analysi... | 2,015 | A Gram-stain-positive, solvent-tolerating, aerobic, rod-shaped bacterium that formed terminal endospores was isolated from the organic solvent acetophenone. The strain, designated JC23T, was oxidase- and catalase-positive. The strain grew in the presence of a wide range of organic solvents with partition coefficients (... | 25740932 | Lysinibacillus acetophenoni sp. nov., a solvent-tolerant bacterium isolated from acetophenone. |
The Journal of neuroscience : the official journal of the Society for Neuroscience | [
"Animals",
"Basal Nucleus of Meynert",
"Cholinergic Agents",
"Cholinergic Neurons",
"Female",
"Male",
"Membrane Potentials",
"Mice",
"Mice, 129 Strain",
"Mice, Inbred C57BL",
"Mice, Transgenic",
"Nerve Net",
"Optogenetics",
"Signal-To-Noise Ratio",
"Somatosensory Cortex"
] | 2,018 | The nucleus basalis (NB) projects cholinergic axons to the cortex, where they play a major role in arousal, attention, and learning. Cholinergic inputs shift cortical dynamics from synchronous to asynchronous and improve the signal-to-noise ratio (SNR) of sensory responses. However, the underlying mechanisms of these c... | 30373769 | Membrane Potential Correlates of Network Decorrelation and Improved SNR by Cholinergic Activation in the Somatosensory Cortex. |
Physical chemistry chemical physics : PCCP | [
"Base Pairing",
"DNA",
"Intercalating Agents",
"Nucleic Acid Conformation",
"Phenanthrolines",
"Solvents",
"Static Electricity",
"Thermodynamics"
] | 2,017 | The effects of oxygen in positions 4,7 and 5,6 of phenanthroline when this ligand intercalates between guanine-cytosine and adenine-thymine DNA base pairs (GC/CG and AT/TA) have been studied at the M06-2X/6-31+G(d,p) level of calculation. We focused on the changes in the structure, stabilization and energy contribution... | 28621352 | Effects of oxygenation on the intercalation of 1,10-phenanthroline-5,6/4,7-dione between DNA base pairs: a computational study. |
Parasitology | [
"Adolescent",
"Adult",
"Animals",
"Antigens, Helminth",
"Brazil",
"Child",
"Child, Preschool",
"Endemic Diseases",
"Enzyme-Linked Immunosorbent Assay",
"Feces",
"Female",
"Humans",
"Male",
"Middle Aged",
"Point-of-Care Testing",
"Prevalence",
"ROC Curve",
"Schistosoma mansoni",
"... | 2,021 | This study aimed to evaluate the performance of the point-of-care circulating cathodic antigen (POC-CCA) test in a highly endemic area in Brazil, comparing it to the Kato-Katz (KK) technique for sensitivity, specificity and the intensity of the reaction of the test in relation to the parasitic load. The community in Se... | 33190646 | Diagnostic comparison of stool exam and point-of-care circulating cathodic antigen (POC-CCA) test for schistosomiasis mansoni diagnosis in a high endemicity area in northeastern Brazil. |
Journal of magnetic resonance (San Diego, Calif. : 1997) | [
"Algorithms",
"Arginine",
"Carbon Isotopes",
"Computer Simulation",
"Electromagnetic Fields",
"Magnetic Resonance Spectroscopy",
"Protons",
"Reproducibility of Results"
] | 2,016 | The paper describes the design of broadband excitation and inversion pulses by method of multiple rotating frame technique. The ideal situation for perfect excitation and inversion is to have no chemical shift offset and thereby everything on resonance. However, when chemical shifts span a wide range, this condition is... | 26896867 | Ultra broadband NMR spectroscopy using multiple rotating frame technique. |
The Science of the total environment | [
"Agriculture",
"Biofuels",
"Brassica rapa",
"Crops, Agricultural",
"Greenhouse Effect",
"Seasons"
] | 2,018 | Rape is a non-grain feedstock with several characteristics that make it suitable for biofuel production, such as high oil yields and low environmental impact. Planting rape on winter fallow fields could allow for seasonal rotation between the bioenergy production and agricultural production. In the present study, the G... | 29428852 | Efficiency analysis of bioenergy potential on winter fallow fields: A case study of rape. |
European radiology experimental | [
"Breast",
"Breast Neoplasms",
"Female",
"Humans",
"Mammography",
"Phantoms, Imaging",
"Radiation Dosage"
] | 2,020 | BACKGROUND: To propose a practical and simple method to individually evaluate the average absorbed dose for digital breast tomosynthesis.METHODS: The method is based on the estimate of incident air kerma (ka,i) on the breast surface. An analytical model was developed to calculate the ka,i from the tube voltage, tube lo... | 32632827 | Average absorbed breast dose (2ABD): an easy radiation dose index for digital breast tomosynthesis. |
Cancer immunology research | [
"Adult",
"Aged",
"Aged, 80 and over",
"CD4-Positive T-Lymphocytes",
"CD8-Positive T-Lymphocytes",
"Cancer Vaccines",
"Combined Modality Therapy",
"Dendritic Cells",
"Female",
"Humans",
"Immunogenicity, Vaccine",
"Inducible T-Cell Co-Stimulator Ligand",
"Interferon-alpha",
"Male",
"Melano... | 2,020 | Therapeutic cancer vaccines targeting melanoma-associated antigens are commonly immunogenic but are rarely effective in promoting objective clinical responses. To identify critical molecules for activation of effective antitumor immunity, we have profiled autologous dendritic cell (DC) vaccines used to treat 35 patient... | 33051240 | Dysregulated NF-�B-Dependent ICOSL Expression in Human Dendritic Cell Vaccines Impairs T-cell Responses in Patients with Melanoma. |
Biochimica et biophysica acta. General subjects | [
"Circular Dichroism",
"DNA",
"DNA Probes",
"Hydrogen-Ion Concentration",
"Nucleic Acid Conformation"
] | 2,018 | I-motif DNA, which can fold and unfold reversibly in various environments, plays a significant role in DNA nanotechnology and biological functions. Thus, it is of fundamental importance to identify the different conformations of i-motif DNA. Here, we demonstrate that distinct structures of i-motif DNA conjugated to pol... | 30048743 | Probing the conformational switch of I-motif DNA using tunable resistive pulse sensing. |
World neurosurgery | [
"Brain Neoplasms",
"Craniotomy",
"Diagnosis, Differential",
"Dizziness",
"Histiocytes",
"Histiocytosis, Sinus",
"Humans",
"Lymph Nodes",
"Male",
"Meningioma",
"Middle Aged",
"Neurosurgical Procedures",
"Treatment Outcome"
] | 2,020 | BACKGROUND: Rosai-Dorfman disease (RDD) is a rare idiopathic benign proliferative disorder of histiocytes, predominantly affecting the lymph nodes. RDD can also present in extranodal tissues and is occasionally found within the central nervous system.CASE DESCRIPTION: We report the case of a 52-year-old man presenting ... | 32035213 | Isolated Intracranial Rosai-Dorfman Disease: Case Report and Review of the Literature. |
Nutrients | [
"Adult",
"Antioxidants",
"Biomarkers",
"Cardiovascular Diseases",
"Cholesterol",
"Cholesterol, HDL",
"Cholesterol, LDL",
"Dietary Supplements",
"Double-Blind Method",
"Healthy Volunteers",
"Humans",
"Hypercholesterolemia",
"Isoflavones",
"Lipids",
"Male",
"Middle Aged",
"Probiotics",... | 2,016 | BACKGROUND: Cardiovascular disease is the leading cause of worldwide morbidity and mortality. Several studies have demonstrated that specific probiotics affect the host's metabolism and may influence the cardiovascular disease risk.OBJECTIVES: The aim of this study was to investigate the influence of an isoflavone-supp... | 26797632 | Probiotic Soy Product Supplemented with Isoflavones Improves the Lipid Profile of Moderately Hypercholesterolemic Men: A Randomized Controlled Trial. |
Journal of proteomics | [
"Aneurysm, Ruptured",
"Cell-Matrix Junctions",
"Focal Adhesions",
"Gene Expression Profiling",
"Humans",
"Inflammation",
"Intracranial Aneurysm",
"Phagosomes",
"Proteomics"
] | 2,018 | The underlying pathophysiological mechanisms involved in cerebral aneurysms rupture remain unclear. This study was performed to investigate the differentially expressed proteins between ruptured and unruptured aneurysms using quantitative proteomics. The aneurysmal walls of six ruptured aneurysms and six unruptured ane... | 29729990 | Quantitative proteomics analysis of differentially expressed proteins in ruptured and unruptured cerebral aneurysms by iTRAQ. |
Angewandte Chemie (International ed. in English) | [
"Alkynes",
"Amino Acids, Cyclic",
"Azepines",
"Benzaldehydes",
"Benzene Derivatives",
"Catalysis",
"Combinatorial Chemistry Techniques",
"Cyclization",
"Indoles",
"Quinolines"
] | 2,015 | A one pot synthesis of 1H-benzo[g]indoles, tetrahydrobenzo[h]quinolines, and naphtho[1,2-b]azepines from 2-alkynyl benzaldehydes and cyclic amino acids is reported. The salient feature of the strategy involves formation of three new bonds (one C-N and two C-C bonds) by a metal-free decarboxylation/cyclization/one-carbo... | 26148838 | Metal-Free Decarboxylative Cyclization/Ring Expansion: Construction of Five-, Six-, and Seven-Membered Heterocycles from 2-Alkynyl Benzaldehydes and Cyclic Amino Acids. |
Nature communications | [
"Aspartic Acid",
"Catalytic Domain",
"Computer Simulation",
"Crystallography, X-Ray",
"Cytoplasm",
"Escherichia coli",
"Escherichia coli Proteins",
"Hydrogen-Ion Concentration",
"Hydrophobic and Hydrophilic Interactions",
"Ions",
"Lysine",
"Molecular Dynamics Simulation",
"Protein Conformati... | 2,016 | Escherichia coli NhaA is a prototype sodium-proton antiporter, which has been extensively characterized by X-ray crystallography, biochemical and biophysical experiments. However, the identities of proton carriers and details of pH-regulated mechanism remain controversial. Here we report constant pH molecular dynamics ... | 27708266 | Mechanism of pH-dependent activation of the sodium-proton antiporter NhaA. |
BMC research notes | [
"Adult",
"Age Distribution",
"Female",
"Geography",
"Humans",
"Kidney Failure, Chronic",
"Male",
"Middle Aged",
"Renal Dialysis",
"Sudan"
] | 2,015 | BACKGROUND: End stage renal failure (ESRF) has become a major health problem in Sub Saharan Africa (SSA). There were limited data about causes of ESRF in the Sudan.METHODS: This is a cross sectional hospital based descriptive study. The subjects of the study are ESRF adults' patients on regular haemodialysis treatment ... | 26419536 | Causes of end stage renal failure among haemodialysis patients in Khartoum State/Sudan. |
The American journal of emergency medicine | [
"Adolescent",
"Adult",
"Aged",
"Alcoholism",
"Asphyxia",
"Bipolar Disorder",
"Blood Glucose",
"Blood Pressure",
"Child",
"Depressive Disorder",
"Diastole",
"Female",
"Follow-Up Studies",
"Glasgow Coma Scale",
"Heart Arrest",
"Humans",
"Hyperglycemia",
"Hypertension",
"Intensive C... | 2,017 | INTRODUCTION: Patients surviving a self-attempted hanging have a total neurological recovery in 57-77% of cases at hospital discharge, but no long-term data are available.METHODS: In this observational study, all patients hospitalized post-self-attempted hanging in the intensive care unit (ICU) in a 5-year period were ... | 28551089 | Prognosis at 6 and 12months after self-attempted hanging. |
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology | [
"3' Untranslated Regions",
"Apoptosis",
"Cell Line, Tumor",
"Cell Proliferation",
"Gene Expression Regulation, Neoplastic",
"Humans",
"MicroRNAs",
"Prognosis",
"Proto-Oncogene Proteins c-met",
"Thyroid Neoplasms"
] | 2,016 | BACKGROUND/AIMS: Thyroid carcinoma (TC) is a highly lethal malignant cancer and its carcinogenesis remains undetermined. Dysregulation of microRNAs (miRNAs) is well known to be involved in the development of various cancers, including TC, whereas a role of miR-3666 in the pathogenesis of TC has not been appreciated.MET... | 26937629 | MicroRNA-3666 Regulates Thyroid Carcinoma Cell Proliferation via MET. |
Journal of burn care & research : official publication of the American Burn Association | [
"Burns",
"Cicatrix, Hypertrophic",
"Contracture",
"Esthetics",
"Facial Injuries",
"Female",
"Humans",
"Osteotomy",
"Reconstructive Surgical Procedures",
"Skin Transplantation",
"Young Adult"
] | 2,019 | Postburn contracture is an undesirable sequel of burn injury which affects patients in many ways. A secondary deformity of the growing skeleton in case of pediatric burn patients is a challenging problem to reconstructive surgeons, and careful planning and staged correction is required for such patients. Here we discus... | 30753524 | Childhood Burns Leading to Skeletal and Soft Tissue Deformities: A Case Report. |
Current biology : CB | [
"Animals",
"Biomechanical Phenomena",
"Escape Reaction",
"Neurons",
"Reaction Time",
"Visual Perception",
"Zebrafish"
] | 2,017 | All visual animals must decide whether approaching objects are a threat. Our current understanding of this process has identified a proximity-based mechanism where an evasive maneuver is triggered when a looming stimulus passes a subtended visual angle threshold. However, some escape strategies are more costly than oth... | 28889979 | Visual Threat Assessment and Reticulospinal Encoding of Calibrated Responses in Larval Zebrafish. |
Physiological research | [
"Aged",
"Aged, 80 and over",
"Cerebrovascular Circulation",
"Cohort Studies",
"Cross-Sectional Studies",
"Female",
"Humans",
"Hypoxia, Brain",
"Kidney Failure, Chronic",
"Male",
"Middle Aged",
"Oximetry",
"Population Surveillance",
"Renal Dialysis",
"Risk Factors"
] | 2,019 | Brain tissue oxygenation (rSO(2)) measured by near-infrared spectroscopy (NIRS) is lower in hemodialysis patients than in the healthy population and is associated with cognitive dysfunction. The involved mechanisms are not known. We conducted this study to identify the factors that influence the rSO2 values in end-stag... | 31177793 | Factors responsible for cerebral hypoxia in hemodialysis population. |
British journal of psychology (London, England : 1953) | [
"Adult",
"Awareness",
"Female",
"Humans",
"Intention",
"Male",
"Memory, Episodic",
"Mental Recall",
"Thinking",
"Young Adult"
] | 2,018 | Involuntary autobiographical memories come to mind effortlessly and unintended, but the mechanisms of their retrieval are not fully understood. We hypothesize that involuntary retrieval depends on memories that are highly accessible (e.g., intense, unusual, recent, rehearsed), while the elaborate search that characteri... | 28872657 | How intention and monitoring your thoughts influence characteristics of autobiographical memories. |
Microbial genomics | [
"Anti-Bacterial Agents",
"Bacteria",
"Carbapenems",
"Ciprofloxacin",
"Computational Biology",
"Drug Resistance, Bacterial",
"Genome, Bacterial",
"Humans",
"Microbial Sensitivity Tests"
] | 2,020 | Antimicrobial resistance (AMR) poses a threat to public health. Clinical microbiology laboratories typically rely on culturing bacteria for antimicrobial-susceptibility testing (AST). As the implementation costs and technical barriers fall, whole-genome sequencing (WGS) has emerged as a 'one-stop' test for epidemiologi... | 32048983 | Discordant bioinformatic predictions of antimicrobial resistance from whole-genome sequencing data of bacterial isolates: an inter-laboratory study. |
Journal of the American Heart Association | [
"Aged",
"Aged, 80 and over",
"Ambulatory Care",
"Emergency Service, Hospital",
"Female",
"Health Status",
"Heart Failure",
"Hospitalization",
"Humans",
"Male",
"Mental Health",
"Middle Aged",
"Minnesota",
"Patient Reported Outcome Measures",
"Prognosis",
"Prospective Studies",
"Risk ... | 2,018 | BACKGROUND: Perceived social isolation has been shown to have a negative impact on health outcomes, particularly among older adults. However, these relationships have not been fully examined among patients with heart failure.METHODS AND RESULTS: Residents from 11 southeast Minnesota counties with a first-ever Internati... | 29794038 | Perceived Social Isolation and Outcomes in Patients With Heart Failure. |
Current gene therapy | [
"Animals",
"Antigen-Presenting Cells",
"Dipeptides",
"Escherichia coli",
"Female",
"Gene Targeting",
"Gene Transfer Techniques",
"Genetic Vectors",
"HEK293 Cells",
"Humans",
"Luciferases",
"Male",
"Mice",
"Mice, Inbred BALB C",
"MicroRNAs",
"Microsatellite Repeats",
"Muscle, Skeletal... | 2,015 | Immune responses to expressed foreign transgenes continue to hamper progress of gene therapy development. Translated foreign proteins with intracellular location are generally less accessible to the immune system, nevertheless they can be presented to the immune system through both MHC Class I and Class II pathways. Wh... | 25545919 | Effects of APC De-targeting and GAr modification on the duration of luciferase expression from plasmid DNA delivered to skeletal muscle. |
Journal of psychosomatic research | [
"Accelerometry",
"Adult",
"Case-Control Studies",
"Exercise",
"Fatigue Syndrome, Chronic",
"Female",
"Humans",
"Middle Aged",
"Quality of Life",
"Reproducibility of Results",
"Self Report",
"Young Adult"
] | 2,021 | OBJECTIVE: To explore the ability of a self-report activity diary to measure the physical activity level (PAL) in female patients with chronic fatigue syndrome (CFS) and whether illness-related complaints, health-related quality of life domains (HRQOL) or demographic factors are associated with discrepancies between se... | 33773330 | An exploratory study of discrepancies between objective and subjective measurement of the physical activity level in female patients with chronic fatigue syndrome. |
Journal of critical care | [
"Aged",
"Aged, 80 and over",
"Aorta",
"Critical Illness",
"Echocardiography",
"Female",
"Hospitalization",
"Humans",
"Hypertension, Pulmonary",
"Intensive Care Units",
"Male",
"Middle Aged",
"Morgue",
"Prognosis",
"Pulmonary Artery",
"Pulmonary Disease, Chronic Obstructive",
"Pulmona... | 2,016 | AIM: Chronic obstructive pulmonary disease (COPD) is one of the leading chronic diseases and a common cause of death. Identification of COPD patients at high risk for complications and mortality is of utmost importance. Computed tomography (CT) can be used to measure the ratio of the diameter of the pulmonary artery (P... | 26936041 | Measurement of pulmonary artery to aorta ratio in computed tomography is correlated with pulmonary artery pressure in critically ill chronic obstructive pulmonary disease patients. |
Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) | [
"Computer Simulation",
"Head and Neck Neoplasms",
"Humans",
"Models, Statistical",
"Phantoms, Imaging",
"Radiation Dosage",
"Radiotherapy Dosage",
"Radiotherapy Planning, Computer-Assisted",
"Radiotherapy, Intensity-Modulated"
] | 2,018 | PURPOSE: To investigate the statistical distribution of the gamma value under error-free conditions, in order to study the relation between the gamma evaluation failure rate and statistically significant deviations in the general situation.METHODS: The 2D absorbed dose distribution for 30 clinical head-and-neck IMRT fi... | 30139608 | Statistical analysis of the gamma evaluation acceptance criteria: A simulation study of 2D dose distributions under error free conditions. |
Nucleic acids research | [
"Amino Acid Motifs",
"Binding Sites",
"Protein Binding",
"Protein Engineering",
"RNA",
"RNA-Binding Proteins",
"Repetitive Sequences, Amino Acid"
] | 2,018 | Pentatricopeptide repeat (PPR) proteins are helical-repeat proteins that offer a promising scaffold for the engineering of proteins to bind specified RNAs. PPR tracts bind RNA in a modular 1-repeat, 1-nucleotide fashion. An amino acid code specifying the bound nucleotide has been elucidated. However, this code does not... | 29294070 | RNA-binding specificity landscapes of designer pentatricopeptide repeat proteins elucidate principles of PPR-RNA interactions. |
The European journal of neuroscience | [
"Adolescent",
"Anorexia Nervosa",
"Brain",
"Case-Control Studies",
"Diffusion Magnetic Resonance Imaging",
"Female",
"Gray Matter",
"Humans"
] | 2,017 | Anorexia nervosa (AN) is a mental health disorder of complex aetiology. Previous neuroimaging studies have found consistent global reductions in global grey matter volume of underweight girls with AN; however, differences in regional grey matter volumes are less consistent. The aims of this study were to investigate gr... | 28833732 | Grey matter volume in adolescents with anorexia nervosa and associated eating disorder symptoms. |
Journal of fish diseases | [
"Animals",
"Asymptomatic Infections",
"Feces",
"Fish Diseases",
"Limit of Detection",
"Oncorhynchus mykiss",
"RNA, Ribosomal, 16S",
"Real-Time Polymerase Chain Reaction",
"Sensitivity and Specificity",
"Yersinia Infections",
"Yersinia ruckeri"
] | 2,018 | Finfish with asymptomatic Yersinia ruckeri infections pose a major risk as they can transmit the pathogen and cause clinical outbreaks in stock populations. Current tools have insufficient quantitative ability for accurately detecting the trace levels of Y.�ruckeri typically associated with asymptomatic infection, nece... | 29926930 | A highly sensitive, non-invasive qPCR-based strategy for direct quantification of Yersinia ruckeri in fish faeces. |
Environmental science and pollution research international | [
"Animals",
"Benzopyrans",
"Carbon",
"Composting",
"Estradiol",
"Estrogens",
"Hydrophobic and Hydrophilic Interactions",
"Manure",
"Soil"
] | 2,018 | Steroid estrogens, such as 17�-estradiol (E2), in animal manure pose a potential threat to the aquatic environment. The transport and estrogenicity of estrogens influence the sorption of estrogens to dissolved organic matter (DOM) in animal manure, and composting treatment alters the structure and composition of the ma... | 29619641 | Sorption of 17�-estradiol to the dissolved organic matter from animal wastes: effects of composting and the role of fulvic acid-like aggregates. |
Journal of psychopharmacology (Oxford, England) | [
"Amygdala",
"Analgesics, Opioid",
"Animals",
"Behavior, Addictive",
"Behavior, Animal",
"Eukaryotic Initiation Factors",
"Extinction, Psychological",
"Gene Expression Regulation",
"Male",
"Morphine",
"Rats",
"Rats, Inbred Lew",
"Regulatory-Associated Protein of mTOR",
"Self Administration"... | 2,019 | BACKGROUND: Addiction is a chronic disorder with a high risk of relapse. The neural mechanisms mediating addictions require protein synthesis, which could be relevant for the development of more effective treatments. The mTOR signaling pathway regulates protein synthesis processes that have recently been linked to the ... | 30887859 | Morphine self-administration alters the expression of translational machinery genes in the amygdala of male Lewis rats. |
The British journal of social psychology | [
"Adult",
"Asians",
"Canada",
"China",
"Cross-Cultural Comparison",
"Female",
"Friends",
"Hong Kong",
"Humans",
"Male",
"Parents",
"Self Concept",
"Social Behavior",
"Whites",
"Young Adult"
] | 2,017 | Personality research has been focused on different aspects of the self, including traits, attitudes, beliefs, goals, and motivation. These aspects of the self are used to explain and predict social behaviour. The present research assessed generalized beliefs about the world, termed 'social axioms' (Leung et�al., ), and... | 28436083 | The added value of world views over self-views: Predicting modest behaviour in Eastern and Western cultures. |
The Lancet. Neurology | [
"Adult",
"Aged",
"Antibodies, Monoclonal, Humanized",
"Double-Blind Method",
"Female",
"Guillain-Barre Syndrome",
"Humans",
"Japan",
"Male",
"Middle Aged",
"Motor Activity",
"Recovery of Function",
"Treatment Outcome"
] | 2,018 | BACKGROUND: Despite the introduction of plasmapheresis and immunoglobulin therapy, many patients with Guillain-Barr? syndrome still have an incomplete recovery. Evidence from pathogenesis studies suggests the involvement of complement-mediated peripheral nerve damage. We aimed to investigate the safety and efficacy of ... | 29685815 | Safety and efficacy of eculizumab in Guillain-Barr? syndrome: a multicentre, double-blind, randomised phase 2 trial. |
mBio | [
"Bacteria",
"Computer Simulation",
"Environmental Microbiology",
"Gene Transfer, Horizontal",
"Genome, Bacterial",
"Interspersed Repetitive Sequences",
"Transformation, Bacterial"
] | 2,020 | Horizontal gene transfer (HGT) promotes the spread of genes within bacterial communities. Among the HGT mechanisms, natural transformation stands out as being encoded by the bacterial core genome. Natural transformation is often viewed as a way to acquire new genes and to generate genetic mixing within bacterial popula... | 32127449 | Bacterial Transformation Buffers Environmental Fluctuations through the Reversible Integration of Mobile Genetic Elements. |
Neotropical entomology | [
"Aedes",
"Animals",
"Brazil",
"Humans",
"Insecticides",
"Larva",
"Lippia",
"Mosquito Control",
"Oils, Volatile",
"Xylopia"
] | 2,017 | In order to find new alternatives for vector control and personal protection, we evaluated the larvicidal and repellent activity of essentials oils from plants found in the Northeast of Brazil against Aedes aegypti Linnaeus mosquitoes. The plants tested include Xylopia laevigata, Xylopia frutescens, and Lippia peduncul... | 27844468 | Repellency and Larvicidal Activity of Essential oils from Xylopia laevigata, Xylopia frutescens, Lippia pedunculosa, and Their Individual Compounds against Aedes aegypti Linnaeus. |
The Analyst | [
"Biosensing Techniques",
"Guanine",
"HeLa Cells",
"Humans",
"Spectrum Analysis, Raman",
"Ultraviolet Rays"
] | 2,017 | In this work, we develop, fabricate, and characterize a plasmonic nanocone array surface enhanced Raman spectroscopy (SERS) substrate with a uniform enhancement factor on the micron scale for qualitative and quantiative cell and cell lysate analysis. This work demonstrates how SERS substrates can be used as cell-based ... | 29068441 | Plasmonic nanocone arrays for rapid and detailed cell lysate surface enhanced Raman spectroscopy analysis. |
American journal of public health | [
"Beverages",
"California",
"Commerce",
"Cross-Sectional Studies",
"Drinking Water",
"Female",
"Humans",
"Male",
"Surveys and Questionnaires",
"Sweetening Agents",
"Taxes"
] | 2,019 | OBJECTIVES: To estimate changes in sugar-sweetened beverage (SSB) and water consumption 3 years after an SSB tax in Berkeley, California, relative to unexposed comparison neighborhoods.METHODS: Data came from repeated annual cross-sectional beverage frequency questionnaires from 2014 to 2017 in demographically diverse ... | 30789776 | Sugar-Sweetened Beverage Consumption 3 Years After the Berkeley, California, Sugar-Sweetened Beverage Tax. |
Journal of aging studies | [
"Aged",
"Aging",
"Emotions",
"Female",
"Humans",
"Interpersonal Relations",
"Male",
"Qualitative Research"
] | 2,020 | PURPOSE: This phenomenological inquiry explored what it is like to become and to be old. The principal aims of this study were to first characterize participants' lived experience of becoming and being an older person, then to determine the extent to which they were aging in a conscious way that evidenced aspects of ge... | 32972615 | Becoming and being an older adult: A mixed methods study of the lived experience of aging. |
Journal of biomedical science | [
"Animals",
"Cell Line",
"Dogs",
"Lactic Acid",
"Mice",
"Nanoparticles",
"Parvovirus, Canine",
"Peptides",
"Polyglycolic Acid",
"Polylactic Acid-Polyglycolic Acid Copolymer"
] | 2,015 | BACKGROUND: Canine parvovirus 2 (CPV-2) remains a significant worldwide canine pathogen and the most common cause of viral enteritis in dogs. The 1 L15 and 7 L15 peptides overlap each other with QPDGGQPAV residues (7-15 of VP2 capsid protein of CPV) is shown to produce high immune response. PLGA nanoparticles were demo... | 26482775 | Preparation, characterization and immunological evaluation: canine parvovirus synthetic peptide loaded PLGA nanoparticles. |
Analytical chemistry | [
"Cystic Fibrosis",
"DNA, Bacterial",
"Humans",
"Point Mutation",
"Pseudomonas aeruginosa",
"Surface Properties"
] | 2,015 | Mictoroids, as optical biosensors, can provide beneficial biosensing platforms to understand DNA alterations. These alterations could have significant clinical importance, such as the case of Pseudomonas aeruginosa, which is a commonly found pathogen in Cystic Fibrosis (CF) patients-causing poor prognosis by undergoing... | 26457918 | Real-Time and Selective Detection of Single Nucleotide DNA Mutations Using Surface Engineered Microtoroids. |
Methods in molecular biology (Clifton, N.J.) | [
"Animals",
"Autopsy",
"Disease Models, Animal",
"Female",
"Humans",
"Mice",
"Mice, Inbred CBA",
"Proteus Infections",
"Proteus mirabilis",
"Urinary Tract Infections"
] | 2,019 | Live animal modeling enables more in-depth realistic methods for studying the pathogenesis of urinary tract infections. Initiating a transurethral urinary tract infection in the female mouse is a challenging endeavor. However, when done with consistency and care, this infection model yields irreplaceable data. The meth... | 31309504 | Independent Transurethral Urinary Tract Inoculation in a Murine Model of Ascending Infection with Proteus mirabilis. |
Emotion (Washington, D.C.) | [
"Adult",
"Communication",
"Emotions",
"Face",
"Facial Expression",
"Facial Recognition",
"Fear",
"Female",
"Humans",
"Male",
"Reproducibility of Results",
"Software",
"Stereotyping",
"Young Adult"
] | 2,017 | According to dominant theories of affect, humans innately and universally express a set of emotions using specific configurations of prototypical facial activity. Accordingly, thousands of studies have tested emotion recognition using sets of highly intense and stereotypical facial expressions, yet their incidence in r... | 28406679 | Gently does it: Humans outperform a software classifier in recognizing subtle, nonstereotypical facial expressions. |
Disability and rehabilitation | [
"Accelerometry",
"Adult",
"Ankle",
"Equipment Design",
"Exercise",
"Female",
"Humans",
"Male",
"Myotonic Dystrophy",
"Physical Functional Performance",
"Reproducibility of Results",
"Task Performance and Analysis",
"Walking Speed",
"Wrist"
] | 2,019 | Background: Accelerometers are accurate tools to assess movement and physical activity. However, interpreting standardly used outputs is not straightforward for populations with impaired mobility.Methods: The applicability of GENEActiv was explored in a group of 30 participants with myotonic dystrophy and compared to a... | 29987963 | Analyzing walking speeds with ankle and wrist worn accelerometers in a cohort with myotonic dystrophy. |
Scientific reports | [
"Antineoplastic Agents, Phytogenic",
"Apoptosis",
"Cell Line, Tumor",
"Cell Proliferation",
"Down-Regulation",
"Drug Screening Assays, Antitumor",
"Female",
"Fruit",
"G2 Phase Cell Cycle Checkpoints",
"Gene Expression Regulation, Neoplastic",
"Humans",
"Phoeniceae",
"Plant Extracts",
"Prot... | 2,021 | Ajwa dates (Phoenix dactylifera L.) have been described in traditional and alternative medicine to provide several health benefits, but their mechanism of apoptosis induction against human triple-negative breast cancer MDA-MB-231 cells remains to be investigated. In this study, we analyzed the phytoconstituents in etha... | 33990623 | Phytochemicals from Ajwa dates pulp extract induce apoptosis in human triple-negative breast cancer by inhibiting AKT/mTOR pathway and modulating Bcl-2 family proteins. |
Zentralblatt fur Chirurgie | [
"Chest Tubes",
"Humans",
"Multiple Trauma",
"Pneumothorax",
"Thoracic Injuries",
"Thoracic Surgical Procedures",
"Wounds, Nonpenetrating"
] | 2,020 | The therapy of severely injured patients is demanding and promising only in an interdisciplinary context. From a thoracic surgical perspective, the blunt chest trauma is in the foreground; as it is the 2nd leading cause of death after traumatic brain injury. The first step is to identify the potentially life-threatenin... | 32097982 | [Thoracic Surgical Aspects of Seriously Injured Patients]. |
British journal of cancer | [
"Adult",
"Aged",
"Alphapapillomavirus",
"Antibodies, Monoclonal, Humanized",
"Antineoplastic Agents, Immunological",
"Biomarkers, Tumor",
"Cell Nucleus",
"Chemoradiotherapy",
"Cisplatin",
"ErbB Receptors",
"Female",
"Gene Dosage",
"Head and Neck Neoplasms",
"Humans",
"Hypoxia-Inducible F... | 2,020 | BACKGROUND: Anti-EGFR-based therapies have limited success in HNSCC patients. Predictive biomarkers are greatly needed to identify the patients likely to be benefited from these targeted therapies. Here, we present the prognostic and predictive association of biomarkers in HPV-negative locally advanced (LA) HNSCC patie... | 32939054 | Prognostic and predictive significance of nuclear HIF1� expression in locally advanced HNSCC patients treated with chemoradiation with or without nimotuzumab. |
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics | [
"Animals",
"Behavior, Animal",
"Brain",
"Brain-Derived Neurotrophic Factor",
"Female",
"Male",
"Maze Learning",
"Memory",
"Mice",
"Mice, Inbred C57BL",
"Mice, Knockout",
"Neurons",
"Receptor, trkB",
"Signal Transduction",
"Sodium-Hydrogen Exchangers",
"Up-Regulation"
] | 2,017 | Nhe5, a Na+ /H+ exchanger, is predominantly expressed in brain tissue and is proposed to act as a negative regulator of dendritic spine growth. Up to now, its physiological function in vivo remains unclear. Here we show that Nhe5-deficient mice exhibit markedly enhanced learning and memory in Morris water maze, novel o... | 28981195 | Nhe5 deficiency enhances learning and memory via upregulating Bdnf/TrkB signaling in mice. |
Neural networks : the official journal of the International Neural Network Society | [
"Artificial Intelligence",
"Computer Simulation",
"Heuristics",
"Neural Networks, Computer",
"Time Perception"
] | 2,017 | Simulation and positioning are very important aspects of computer aided engineering. To process these two, we can apply traditional methods or intelligent techniques. The difference between them is in the way they process information. In the first case, to simulate an object in a particular state of action, we need to ... | 28544890 | Hybrid neuro-heuristic methodology for simulation and control of dynamic systems over time interval. |
Nuclear medicine communications | [
"Adult",
"Aged",
"Arthroplasty, Replacement, Hip",
"Early Diagnosis",
"Female",
"Humans",
"Male",
"Middle Aged",
"Prosthesis Failure",
"Single Photon Emission Computed Tomography Computed Tomography",
"Stress, Mechanical"
] | 2,021 | OBJECTIVE: Hip pain arising from implant instability is generally caused by repetitive stress injury, which subsequently leads to induction or exacerbation of abnormal metabolism of bone around the implant. single photon emission tomography/computed tomography (SPECT-CT) has advantages in localizing areas of increased ... | 33306622 | Clinical usefulness of single photon emission tomography/computed tomography with stress analysis in early diagnoses of stem instability of noncemented hip arthroplasty. |
Acta biomaterialia | [
"Chitosan",
"Humans",
"Porosity",
"Stents",
"Ureter"
] | 2,019 | As a new strategy for improved urinary drainage, in parallel to the potential for additional functions such as drug release and self-removal, highly porous chitosan stents are manufactured by radial, bi-directional freeze-casting. Inserting the porous stent in to a silicone tube to emulate its placement in the ureter s... | 30414484 | Freeze-casting porous chitosan ureteral stents for improved drainage. |
Cytokine | [
"Adolescent",
"Adult",
"Aged",
"Biomarkers",
"Case-Control Studies",
"Cell Adhesion Molecules",
"Cytokines",
"Female",
"Humans",
"Inflammation",
"Male",
"Middle Aged",
"Monitoring, Physiologic",
"Mycobacterium tuberculosis",
"Recurrence",
"Th1 Cells",
"Th17 Cells",
"Th2 Cells",
"... | 2,018 | Relapse of pulmonary tuberculosis (PTB) is associated with a failure of the host immune system to control the invading Mycobacterium tuberculosis. Severe immunodeficiency or immune disorders may be the main reason for TB recurrence. This study aimed to quantify serum inflammatory cytokine and soluble adhesion molecule ... | 29554572 | Cytokine and soluble adhesion molecule profiles and biomarkers for treatment monitoring in Re-treated smear-positive patients with pulmonary tuberculosis. |
Journal of economic entomology | [
"Amino Acid Sequence",
"Animals",
"Escherichia coli",
"Insecticides",
"Mitochondria",
"Moths",
"Recombinant Proteins",
"Sequence Analysis, DNA",
"Stress, Physiological",
"Superoxide Dismutase",
"Temperature"
] | 2,018 | In insects, superoxide dismutases (SODs) play a critical role in the scavenging of harmful reactive oxygen species (ROS) and protecting against oxidative stress induced by various environmental stresses. The Asiatic rice borer, Chilo suppressalis (Walker) (Lepidoptera: Crambidae), is an economically important insect pe... | 29939281 | Molecular Characterization of a Mitochondrial Manganese Superoxide Dismutase From Chilo suppressalis (Lepidoptera: Crambidae). |
Leukemia | [
"Animals",
"Antineoplastic Agents",
"Cell Line, Tumor",
"Disease Models, Animal",
"Gene Deletion",
"Gene Expression Regulation, Leukemic",
"Gene Rearrangement",
"Histone-Lysine N-Methyltransferase",
"Leukemia, Myeloid, Acute",
"Mice",
"Mice, Inbred NOD",
"Mice, SCID",
"Myeloid-Lymphoid Leuke... | 2,018 | The hematological malignancies classified as mixed lineage leukemias (MLL) harbor fusions of the MLL1 gene to partners that are members of transcriptional elongation complexes. MLL-rearranged leukemias are associated with extremely poor prognosis, and response to conventional therapies and efforts to identify molecular... | 28663579 | Genetic deletion or small-molecule inhibition of the arginine methyltransferase PRMT5 exhibit anti-tumoral activity in mouse models of MLL-rearranged AML. |
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology | [
"Electrophoresis, Agar Gel",
"Electrophoresis, Gel, Pulsed-Field",
"Europe",
"Humans",
"Laboratory Proficiency Testing",
"Minisatellite Repeats",
"Molecular Typing",
"Salmonella"
] | 2,017 | We report the results of three consecutive External Quality Assessments (EQAs) for molecular subtyping of Salmonella to assess the performance of the European national public health reference laboratories (NPHRLs). The EQA included the molecular typing methods used for European enhanced surveillance of human Salmonella... | 28573470 | External quality assessment for molecular typing of Salmonella 2013-2015: performance of the European national public health reference laboratories. |
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery | [
"Bone Plates",
"Female",
"Femoral Fractures",
"Fracture Fixation, Internal",
"Fracture Healing",
"Humans",
"Male",
"Retrospective Studies",
"Treatment Outcome"
] | 2,019 | Objective: To explore the early effectiveness and advantages of mini-Swashbuckler approach in treatment of distal femoral type C fractures by comparing with Swashbuckler approach.Methods: A retrospective analysis was made on 43 patients with distal femoral type C fractures between January 2014 and June 2018. Twenty-two... | 31512454 | [Early effectiveness of mini-Swashbuckler approach for distal femoral type C fractures]. |
Forensic science international | [
"Aged",
"Calcaneus",
"Discriminant Analysis",
"Female",
"Forensic Anthropology",
"Greece",
"Humans",
"Male",
"Sex Determination by Skeleton"
] | 2,017 | During the past decade, several studies have been carried out using the calcaneus bone for sex estimation. This paper collected data using ten variables for metric characteristics of the calcaneus of 144 modern Cretans and examined their correlation with known sex. Secondly, the formulae developed by Peckmann et al. (2... | 28625510 | Sexual dimorphism of the calcaneus in contemporary Cretans. |
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