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patrepeval

patent_id large_string	title large_string	abstract large_string	year_filed int16	year_granted int16	label int8
6248077	System for sensing a characteristic of fluid flowing to or from a body	A system for sensing a characteristic of fluid flowing to or from the body of a human or a comprising a conduit having a first end adapted to be outside the body, a second end adapted to be received within the body, and a flow passage through which fluid can flow between the first and second ends and a probe including...	1,985	2,001	1
6608241	Protection of plants against viral infection	The invention involves recombinant, double-stranded DNA that contains a promoter which functions in plant cells to cause the production of RNA sequences of a plant virus, a DNA sequence that causes the production of an RNA sequence encoding the coat protein of said plant virus, and a 3′ non-translated region whic...	1,986	2,003	1
7056866	Superconductivity in square-planar compound systems	Described is a superconducting composition comprising an oxide complex of the formula [L1−xMx]aAbOy wherein L is lanthanum, lutetium, yttrium, or scandium; A is copper, bismuth, titanium, tungsten, zirconium, tantalum, niobium, or vanadium; M is barium, strontium, calcium, magnesium or mercury; and “a” is 1 to 2; “b” i...	1,987	2,006	1
8757167	Precise snuff portion packaging machine	A machine for forming, continuously, distinct portions of particulate matter such as smokeless tobacco, i.e., snuff, in a pouch or pocket form, and continuously forming individual pouches or pockets containing the distinct portions of the particulate matter.	1,987	2,014	1
6307030	Androgen receptor proteins, recombinant DNA molecules coding for such, and use of such compositions	DNA sequences encoding human androgen receptor protein and polypeptides and proteins having substantially the same biological activity as human androgen receptor protein and the amino acid sequences of human androgen receptor protein and polypeptides and proteins having substantially the same biological activity as hu...	1,988	2,001	1
6544757	Synthesis of human virus antigens by yeast	The present invention relates to synthesis of HBSAg in yeast. Yeast expression vectors comprising a yeast promoter, ADH1, have been constructed. The region of the HBV genome coding for the S-protein, excluding a possible 163 amino acid presequence, has been transferred to the yeast expression vector. Using the describe...	1,988	2,003	1
7709418	High transition temperature superconducting compositions	Described is a superconducting composition comprising an oxide complex of the formula [L1−xMx]aAbOy wherein L is lanthanum, lutetium, yttrium or scandium; A is copper, bismuth, titanium, tungsten, zirconium, tantalum, niobium, or vanadium; M is barium, strontium, calcium, magnesium or mercury; and “a” is 1 to 2; “b” is...	1,989	2,010	1
8227191	Method for amplification and detection of RNA sequences	A process for identifying a viral RNA nucleotide sequence present in a sample of peripheral blood cells which comprises amplifying such RNA simultaneously with at least one other RNA nucleotide sequence present in a virus infected cell in said sample, and thereafter separately and sequentially analyzing the amplificati...	1,989	2,012	1
6692941	Bovine growth hormone	A DNA comprising a deoxynucleotide sequence coding for bovine growth hormone is described. A transfer vector and an expression vector containing this DNA and microorganisms transformed by these vectors are also described.	1,990	2,004	1
6448381	DNA encoding heparin-binding growth factor	A novel heparin-binding growth factor of 18.9 kDa mol. wt. is disclosed which is purified from bovine uterus and human placenta and has a unique 25 N-terminal amino acid sequence as follows:Gly-Lys-Lys-Glu-Lys-Pro-Glu-Lys-Lys-Val-Lys-Lys-Ser-Asp-Cys-Gly-Glu-Trp-Gln-Trp-Ser-Val-Cys-Val-Pro.	1,990	2,002	1
6248577	Hypoxanthine-guanine phosphoribosyl transferase	The present invention describes the previously unreported cloning and isolation of HGPRT cDNA containing an open reading frame corresponding to the HGPRT of Plasmodium falciparum, present the complete nucleotide sequence of the Plasmodium falciparum HGPRT Dral/Pstl cDNA fragment, and the expression of this gene produc...	1,990	2,001	1
6682906	Cloned glutamic acid decarboxylase	cDNA molecules coding for GAD65 polypeptide are disclosed. The invention provides cDNA molecules comprising a part of the cDNA sequence of GAD65 which encode at least one epitope for autoantibodies to GAD65. The invention also provides cloning vehicles capable of replication and expression comprising cDNA molecules cod...	1,990	2,004	1
6265214	Methods and compositions for inducing monocyte cytotoxicity	The present disclosure relates to a new lymphokine molecule, referred to as Monocyte Cytotoxicity Inducing Factor (MCF), and its use as in cancer and other types of therapy. The disclosure further relates to the development of novel Sezary cell hybridomas which secrete MCF and thereby provide a ready source for MCF is...	1,990	2,001	1
6215439	Emitter identification from radio signals using filter bank algorithm	An algorithm for emitter identification of a transmitting platform using spectral energy analysis, and a system utilizing said algorithm, wherein said algorithm processes audio signals from transmission data using a fast fourier transform, detecting gaps in said processed transmission data. It then extracts spectral f...	1,990	2,001	1
6215440	Emitter identification from radio signals using keyclick algorithm	An algorithm for emitter identification of a transmitting platform using microphone keyclick analysis, and a system utilizing said algorithm, wherein said algorithm processes audio signals to detect transmission activity on a radio channel in the audio frequency range, detects the boundaries of transmitter keyclicks a...	1,990	2,001	1
6303339	DNA segments encoding autoimmune polypeptide epitopes of Ro/ss-A antigen	The present disclosure relates to DNA sequences encoding one or more antigenic epitopes of the Ro 60 kD autoantigen, as well as to antigenic peptides themselves which correspond antigenically to epitopes found on the Ro/SS-A ribonucleoprotein (RNP) particle. Peptides which incorporate the antigenic epitopic core seque...	1,991	2,001	1
6263878	Means for protecting living systems from adverse effects of electric, magnetic and electromagnetic fields	An arrangement for inhibiting the adverse effect of an ambient time varying field having an electric component of 5 Kv/M or less and/or a magnetic component of 500 .mu.T or less on a living system. To provide protection, at least one of the characteristic parameters of said field to which the living system is exposed ...	1,991	2,001	1
6432919	Bone morphogenetic protein-3 and compositions	Purified BMP-3 proteins and processes for producing them are disclosed. They may be used in the treatment of bone and cartilage defects and in wound healing and related tissue repair.	1,991	2,002	1
6492137	Response element compositions and assays employing same	DNA segments have been discovered, and characterized by sequence, which are response elements operative to confer responsiveness to ligands for several members of the steroid/thyroid superfamily of receptors, for the transcriptional activation and/or repression of promoters in cells. By using transcriptional control re...	1,991	2,002	1
6261825	Production of amino acids using auxotrophic mutants of methylotrophic bacillus	A method of producing amino acids by culturing an amino acid auxotroph of a biologically pure strain of a type I methylotrophic bacterium of the genus Bacillus which exhibits sustained growth at 50.degree. C. using methanol as a carbon and energy source and requiring vitamin B.sub.12 and biotin is provided.	1,991	2,001	1
6348191	Production and use of IL-6	IL-6 is produced via recombinant DNA techniques. The peptide is useful in the treatment of disorders characterized by deficiencies in hematopoietic cells and in combination with other hematopoietins in cancer therapies.	1,991	2,002	1
6287792	Drug delivery of antisense oligonucleotides and peptides to tissues in vivo and to cells using avidin-biotin technology	A composition for delivering an agent to cells in vitro or to tissues or organs in vivo. The composition comprises either avidin or an avidin fusion protein bonded to a biotinylated agent to form an avidin-biotin-agent complex. A method is further provided for delivering an agent to cells using the avidin-biotin-agent...	1,991	2,001	1
6180337	Diagnosis of the fragile X syndrome	A sequence of the FMR-1 gene is disclosed. This sequence and related probes, cosmids and unique repeats are used to detect X-linked diseases and especially the fragile X syndrome. Also, methods using methylation-sensitive restriction endonuclease and PCR primer probes were used to detect X-linked disease.	1,991	2,001	1
6433142	Megakaryocyte stimulating factors	Novel human megakaryocyte stimulating factors (MSFS) capable of stimulating the growth and development of colonies of megakaryocytes, pharmaceutical compositions containing same, and methods for their preparation and use are provided.	1,991	2,002	1
6230233	Wear leveling techniques for flash EEPROM systems	A mass storage system made of flash electrically erasable and programmable read only memory ("EEPROM") cells organized into blocks, the blocks in turn being grouped into memory banks, is managed to even out the numbers of erase and rewrite cycles experienced by the memory banks in order to extend the service lifetime o...	1,991	2,001	1
6475787	Method for producing monoclonal antibodies	An improved method for the production of monoclonal antibodies is disclosed.	1,991	2,002	1
6225449	Hormone analogs with multiple CTP extensions	The invention provides peptide and protein pharmaceuticals with extended half-lives. The modified peptides and proteins of the invention contain at least two tandem extensions at their C-terminus comprising the carboxy terminal portion of human chorionic gonadotropin. These "CTP units" consist essentially of the native...	1,991	2,001	1
6391590	Recombinant streptavidin-metallothionein chimeric protein having biological recognition specificity	Streptavidin-metallothionein chimeric proteins with biological recognition specificity in which the streptavidin moiety provides high affinity biotin binding and the metallothionein moiety provides a high affinity metal binding. The binding affinity of the streptavidin-metallothionein chimeric protein both for biotin a...	1,991	2,002	1
6649379	Method and deregulated enzyme for threonine production	Mutagenesis of the gene encoding homoserine dehydrogenase (hom) for production of the amino acid threonine is described. The mutation causes an alteration in the carboxy terminus of the enzyme that interferes with end-product inhibition by threonine. The lack of end-product inhibition causes an overproduction of threon...	1,991	2,003	1
6210873	Methods and compositions for the priming of specific cytotoxic T-lymphocyte response	The present invention discloses a novel method for the rapid screening of candidate cytotoxic T lymphocyte- (CTL-) inducing compounds, such as peptides, by the in vivo priming of CTLs with synthetic peptides. The use of compounds so identified for the development of CTL vaccines for the treatment of various infectious...	1,991	2,001	1
6185024	Laser multiplexing system	A plurality of copper lasers, as radiant power sources, emits a beam of power carrying radiation. A plurality of fiber injection assemblies receives power from the plurality of copper lasers and injects such power into a plurality of fibers for individually transmitting the received power to a plurality of power-recei...	1,991	2,001	1
8003342	Method for identifying farnesyl transferase inhibitors	Disclosed are methods and compositions for the identification of inhibitors of farnesyl protein transferases, enzymes involved in the farnesylation of various cellular proteins, including cancer related ras proteins such as p21ras. One farnesyl protein transferase which is disclosed herein exhibits a molecular weight o...	1,991	2,011	1
6200747	Method and kits for detection of fragile X specific, GC-rich DNA sequences	A method is provided for amplifying and detecting specific GC-rich nucleic acid sequences contained in a nucleic acid or in a mixture of nucleic acids, which includes treating a separate nucleic acid containing the specific sequence with a molar excess of primers and a polymerase and extending the primers in the prese...	1,992	2,001	1
6242173	Immunoassays for catalytically-active, serine proteases	Methods for detecting and/or quantifying catalytically-active, serine proteases in a biological fluid are disclosed. The methods are useful for measuring the active enzymes of the coagulation/fibrinolytic system and evaluating the system or components of the system as indicative of thrombosis-related disorders. The me...	1,992	2,001	1
6384191	Receptors for fibroblast growth factors	A fibroblast growth factor (FGF) receptor including a basic fibroblast growth factor receptor has been purified. Various forms have been identified including soluble forms lacking any transmembrane segment. DNA sequences encoding full-length fibroblast growth factor receptors and polypeptides comprising a portion of an...	1,992	2,002	1
6265539	Prophylaxis and therapy of acquired immunodeficiency syndrome	An active peptide consisting essentially of 7 to about 30 residue and having a sequence that corresponds to a conserved domain of an HIV protein is disclosed, as is a multimer containing that peptide, an aqueous composition containing the multimer and methods of using and making the same. The aqueous composition conta...	1,992	2,001	1
6335008	Hybrid genes incorporating a DNA fragment containing at least one gene encoding an insecticidal protein and a gene encoding a glutamine synthase inhibitor, plasmids, transformed cyanobacteria expressing such proteins and method for use as biocontrol agent	Cyanobacteria incorporating a gene from Bacillus sp. encoding for insecticidal proteins (endotoxins) is described. The endotoxins are particularly effective against Diptera (mosquito) larvae. Recombinant vectors for transforming DNA fragments of the endotoxin gene or genes into the Cyanobacterium are described. The Cya...	1,992	2,002	1
6429208	Methods and compositions for restoring impaired cellular immune function	The effect of HIV components on lymphocytes, as exemplified by peripheral blood mononuclear cells (PBMC) in retarding their proliferation can be reversed by inhibiting the PKA/cAMP pathway. By using protocols which inhibit this pathway, the ability of lymphocytes to proliferate can be restored. The restoration of this ...	1,992	2,002	1
6897287	Ro/SSA peptide reagents for diagnosis of autoantibodies	A number of octapeptides were generated from the sequences encoding the 60 kDa Ro/SSA peptide, the La/SSB autoantigen, the 70 kD nuclear ribonucleoprotein (nRNP), and the Sm B/B′ polypeptide, which represent linear epitopes for autoantibodies present in the sera of SLE and SS patients. These peptides are useful in soli...	1,992	2,005	1
6197346	Bioadhesive microspheres and their use as drug delivery and imaging systems	Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, diagnostic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres all have a bioadhesive force of at least 11 mN/cm.sup....	1,992	2,001	1
6613317	Volatile attractants for diabrotica species	Disclosed are attractants and lures for attracting and controlling the adult form of Diabrotica species, in particular northern corn rootworm, useful individually or in mixtures and in combination with insecticides and compulsive feeding stimulants, such as cucurbitacins.	1,992	2,003	1
6780630	Parenteral immunization against rotavirus	The invention relates to an improved rotavirus vaccine for man and animals and methods of using them. The invention comprises a method of immunizing humans, particularly children, and animals against rotavirus infections by parenteral immunization. The immunization may be carried out in a series of injections using liv...	1,992	2,004	1
6656477	43 Kd protein vaccine and method for the production thereof	A protein derivable from Actinobacillus pleuropneumoniae (APP) having a molecular size ranging between 43 Kd on SDS PAGE is described. The protein is soluble on sodium lauryl sarcosinate (SLS) and not heat modifiable. The protein can also be derived by recombinant methods. The protein in a vaccine provides immunity aga...	1,992	2,003	1
6214538	Differentiation of avian infectious bronchitis virus serotypes	The present invention relates, in general, to the genetics of viruses. In particular, the present invention provides methods of distinguishing between serotypes of avian infectious bronchitis virus based on restriction fragment length polymorphisms derived from the region of the S1 gene of IBV, peptides derived from t...	1,992	2,001	1
6355476	Nucleic acid encoding MIP-1&agr; Lymphokine	Full length cDNAs, L2G25B and 4-1BB, were isolated and sequenced. The cDNA L2G25B encodes for the lymphokine, macrophage inflammatory protein-1&agr; or MIP-1&agr;. The studies disclosed herein suggest that MIP-1&agr; and MIP-&bgr; can, through rapid action, modulate early myeloid progenitor cell proliferation. Recombin...	1,992	2,002	1
10016914	Positive displacement molding of plastic parts	The present invention is a method and apparatus for molding plastic parts and placing and orienting reinforcing fibers within structurally thin sections. More specifically, the method of the present invention is a molding technique wherein positive displacement is applied to incremental sections of a charge (plastic mi...	1,992	2,018	1
6500488	Method of forming fluorine-bearing diamond layer on substrates, including tool substrates	A method of forming a fluorine-bearing diamond layer on non-diamond substrates, especially on tool substrates comprising a metal matrix and hard particles, such as tungsten carbide particles, in the metal matrix. The substrate and a fluorine-bearing plasma or other gas are then contacted under temperature and pressure ...	1,992	2,002	1
6446032	Designing compounds specifically inhibiting ribonucleic acid by binding to the minor groove	A method for designing compounds specifically targeting RNA sequences, based on the discovery of short, specific sequences within RNA that are critical to function, using modeling of the compound to effect binding to the nucleotide sequences in the RNA in combination with secondary and/or tertiary structure associated ...	1,992	2,002	1
6258938	Method for the purification and isolation of blood clotting proteins using conformation specific antibodies	A method of isolating a protein from a mixture containing the protein, the method including providing an antibody immobilized on a solid support, which antibody is reactive with the protein complexed with a ligand and substantially unreactive with the protein not complexed with the ligand; contacting the mixture, in t...	1,992	2,001	1
6291158	Method for tapping the immunological repertoire	The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.	1,992	2,001	1
6291159	Method for producing polymers having a preselected activity	The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.	1,992	2,001	1
6291160	Method for producing polymers having a preselected activity	The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.	1,992	2,001	1
6291161	Method for tapping the immunological repertiore	The present invention relates to a method for isolating from the immunological gene repertoire a gene coding for a receptor having the ability to bind a preselected ligand. Receptors produced by the gene isolated by the method, particularly catalytic receptors, are also contemplated.	1,992	2,001	1
6458360	Soluble complement regulatory molecules	This invention is directed to a soluble recombinant fused protein which is stable in the mammalian circulatory system comprising a polypeptide which contains a recognition site for a target molecule, such as a complement receptor site, and is joined to the N-terminal end of an immunoglobulin chain. The invention is als...	1,992	2,002	1
6262375	Room temperature dielectric HTSC cable	A high temperature superconducting cable comprises a cryogenic core, with a superconducting material either inside the cryogenic core or wrapped around the core. A space maintained at a vacuum and functioning as a cryostat surrounds the core; within this space are a separator and superinsulation. A conventional dielec...	1,992	2,001	1
6262798	Method and apparatus for direct spectrophotometric measurements in unaltered whole blood	A method and apparatus that allows accurate spectrophotometric determination of the concentrations of various hemoglobin species in whole blood without hemolysis or dilution. To overcome the complex optical properties of whole blood, the invention employs 1) an optical apparatus designed to maximize the true optical a...	1,992	2,001	1
6471962	Monoclonal antibodies for infectious bursal disease, vaccines and assays for use therewith	Two monoclonal antibodies which neutralize all infectious bursal disease viruses are employed in the preparation of infectious bursal disease vaccines. A panel of monoclonal antibodies can be used to characterize the infectious bursal disease virus strains present, according to neutralization site characteristics.	1,992	2,002	1
6294593	Method and crosslinkable polymers for forming crosslinked second order nonlinear optical polymers	Crosslinkable polymers which can exhibit second order nonlinear optical properties and methods of forming and crosslinking such polymers are disclosed. The crosslinkable polymers are combined with a crosslinking agent. Optionally, the crosslinking agent can exhibit second order nonlinear optical properties. In one emb...	1,992	2,001	1
6329436	Process to recycle shredder residue	A system and process for recycling shredder residue, in which separating any polyurethane foam materials are first separated. Then separate a fines fraction of less than about 1/4 inch leaving a plastics-rich fraction. Thereafter, the plastics rich fraction is sequentially contacted with a series of solvents beginning...	1,992	2,001	1
6218525	Nucleic acid encoding CD28	A simple and highly efficient method for cloning cDNAs from mammalian expression libraries based on transient expression in mammalian host cells has been discovered. Novel expression vectors allowing highly efficient construction of mammalian cDNA libraries are disclosed. The cloning method of the invention which has ...	1,992	2,001	1
6436700	Anti-sense p21 k-ras	Disclosed are methods and compositions for the selective inhibition gene expression through the application of antisense RNA technology. Antisense RNA constructs of the present invention employ the use of antisense intron DNA corresponding to distinct intron regions of the gene whose expression is targeted for down-reg...	1,992	2,002	1
6518418	Nucleotide sugars	Phosphite linked nucleotide sugars, e.g. nucleoside-monophosphite-glycosides, are synthesized using phosphoramiditing agents. The success of the synthetic method is largely independent of the choice of sugar and of nucleotide. The phosphite linked nucleotide sugars are shown to be useful, in the presence of an oxidizin...	1,992	2,003	1
6387363	Biocompatible medical devices	Biocompatible medical devices, including sutures, are disclosed which are produced from polyesters formed from lactide and glycolide copolymers. In a preferred mode of the invention, the biocompatible medical devices are absorbable.	1,992	2,002	1
6238861	Neurofibromatosis gene	The invention relates to the gene involved in the von Recklinghausen neurofibromatosis (NF1) disease process and to the identification, isolation and cloning of a nucleic acid sequence corresponding to the gene. The invention further relates to the NF1 gene product and sequence and antibodies raised thereto. The inven...	1,993	2,001	1
6335159	Retinoic acid receptor &egr;(rar&egr;)	This invention relates to substantially purified Retinoic Acid Receptor &egr; (RAR&egr;), having the amino acid sequence given in FIG. 1, and to the isolated nucleic acid encoding RAR&egr;. In addition, polypeptides comprising, and nucleic acids encoding, the DNA-binding and hormone-binding domain of the receptor are p...	1,993	2,002	1
6362325	Murine 4-1BB gene	The present invention includes the receptor protein 4-1BB and the cDNA gene encoding for receptor protein 4-1BB. The nucleotide sequence of the isolated cDNA is disclosed herein along with the deduced amino acid sequence. The 4-1BB protein and fragments and derivatives can be used: 1) as a probe to isolate ligands to r...	1,993	2,002	1
6197541	Recombinant thrombin receptors and assays using them	The DNA encoding the cell surface receptor for thrombin has been cloned and sequenced. The availability of this DNA permits the recombinant production of thrombin receptor which can be produced at cell surfaces and is useful in assay systems both for the detection of thrombin and for the evaluation of candidate thromb...	1,993	2,001	1
8062642	Production of papillomavirus capsid protein and virus-like particles	The present invention is directed to a method of expressing the papillomavirus capsid protein coding sequence in a cell using an expression system under conditions facilitating expression of the protein in the cell.In another aspect of the invention, it has been discovered that virus-like particle(s) (VLPs), fragment(s...	1,993	2,011	1
6265442	Treatment of neurological diseases by increasing brain concentrations of kynurenic acid	Neurological diseases such as Huntington's caused by the toxic effects of excetatory amino acids are alleviated by administering metabolic precursors of kynurenic acid to afflicted individuals. These metabolic precursors include kynurenine and tryptophan. Since the amount of kynurenic acid in Huntington's Disease pati...	1,993	2,001	1
6203775	Chelating polymers for labeling of proteins	A method of labelling a protein with a metal involving chelating a metal to a compound, with a molecular weight of at least 1,000, and a reactive group capable of forming a covalent bond with a target protein, and conjugating the metallically-labelled compound to a protein.	1,993	2,001	1
6800617	Methods for restoring wild-type p53 gene function	Methods are provided for restoring wild-type p53 gene function to a cell. Such methods include gene therapy. Typically, this will stop tumor cells from proliferating.	1,993	2,004	1
6235525	Isolated nucleic acid molecules coding for tumor rejection antigen precursor MAGE-3 and uses thereof	The invention relates to nucleic acid molecules which code for the tumor rejection antigen precursor MAGE-3. Also disclosed are vectors, cell lines, and so forth, which utilize the nucleic acid molecule, and optionally, molecules coding for human leukocyte antigen HLA-A1. Uses of these materials in therapeutic and dia...	1,993	2,001	1
6326017	Methods for the localized delivery of agents to blood vessels	Methods for the localized delivery of agents to blood vessels are disclosed. The methods of the present invention provide advantages over existing methods for treating, diagnosing, or preventing, vascular disorders. Localized delivery of agents permits the use of agents, such as heparin, for which systemic distributio...	1,993	2,001	1
6217908	Bioadhesive microspheres and their use as drug delivery and imaging systems	Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. The polymeric microspheres all have a bioadhesive force of at least 11 mN/cm.sup.2 (110 N/m.s...	1,993	2,001	1
6175000	Nucleic acids encoding human trithorax protein	In accordance with the present invention, there is provided an isolated peptide having the characteristics of human trithorax protein (as well as DNA encoding same, antisense DNA derived therefrom and antagonists therefor). The invention peptide is characterized by having a DNA binding domain comprising multiple zinc ...	1,993	2,001	1
6333168	Cloning, expression and uses of dorsalin-1	This invention provides an isolated vertebrate nucleic acid molecule which encodes dorsalin-1. This invention also provides a nucleic acid probe capable of specifically hybridizing with a sequence included within the sequence of a nucleic acid molecule encoding a dorsalin-1. The invention also provides a vector and ho...	1,993	2,001	1
6576784	Antiviral agents	Novel antiviral (including antiretroviral) compounds are mono- or dicarboxylic acid esters of hypericin in which one or both of the methyl groups of hypericin are substituted by carboxylic acid ester groups of the formula COOR3 in which R3 is alkyl, the chain of which is optionally interrupted by one or more oxygen or ...	1,993	2,003	1
6326361	Gangliosides with immunosuppressive activity	A method for suppressing immune responses in animals by administering gangliosides to the animal. Gangliosides having terminal sialic acid groups are disclosed as being especially effective as immunosuppressive agents. The especially effective immunosuppressive gangliosides include G.sub.M4 and G.sub.M5. Ganglioside c...	1,993	2,001	1
6224608	Tissue holding device and method	A tissue gripping thread configuration for securely positioning an elongated medical instrument relative to body tissue. The tissue gripping thread includes curved distal and proximal foot sections connected to a thread base, a curved distal thread surface extending from the distal foot section to a thread apex, and a...	1,993	2,001	1
6696061	Immunomodulatory peptides	A purified preparation of a peptide consisting essentially of an amino acid sequence identical to that of a segment of a naturally-occurring human protein, said segment being of 10 to 30 residues in length, inclusive, wherein said peptide binds to a human major histocompatibility complex (MHC) class II allotype.	1,993	2,004	1
6184232	Analogs of biologically active, naturally occurring polyamines, pharmaceutical compositions and methods of treatment	Polyamines having the formula: ##STR1## or a salt thereof with a pharmaceutically acceptable acid wherein: R.sub.1 -R.sub.6 may be the same or different and are alkyl, aryl, aryl alkyl, cycloalkyl, optionally having an alkyl chain interrupted by at least one etheric oxygen atom, or hydrogen; PA1 N.sup.1, N.sup.2, N.su...	1,993	2,001	1
6849427	Nucleic acids encoding a house dust mite allergen, Der p VII, and uses therefor	A novel protein allergen Der p VII of Dermatophagoides pteronyssinus is described. A cDNA clone encoding Der p VII was isolated from a λgt11 library of D. pteronyssinus cDNA. The nucleic acid sequence of Der p VII encodes a 198 residue mature processed protein having a predicted molecular weight of 22,177 daltons. Der ...	1,993	2,005	1
6362160	Immunophilin-binding agents prevent glutamate neurotoxicity associated with vascular stroke and neurodegenerative diseases	Immunophilin-binding agents inhibit the phosphatase calcineurin, leading to the increased phosphorylation of certain brain proteins, including nitric oxide synthase. The increased levels of phosphorylation of nitric oxide synthase inhibits the enzymatic production of nitric oxide. Thus the neurotoxic effects of glutama...	1,993	2,002	1
6274134	Human cell adhesion protein AAMP-1 and uses thereof	The present invention relates, in general, to AAMP-1, and to a peptide derived from the amino-terminal region of AAMP, P189. In particular, the present invention relates to a DNA segment encoding AAMP-1, P189 or fragments thereof; polypeptides encoded by said DNA segment; recombinant DNA molecules containing the DNA s...	1,993	2,001	1
6365578	Drug cominbations containing AZT	Combinations of 3′-azido-3′-deoxythymidine (AZT) with 5-fluorouracil (FUra) or its precursor 5-fluoro-2′-deoxyuridine (FUDR) or methoxtrexate (MTX) exhibit increased cytotoxicity and increased therapeutic index in treatment of carcinomas.	1,993	2,002	1
6965059	Method of protecting plants by introducing a gene coded for a protein which enhances virus infection of host insects	Recent advances of the research on synergistic effect of a mixed baculovirus infection demonstrated the presence of viral molecules enhancing the early event of infection. The enhancins from the Trichoplusia ni was identified to have such a function, i.e., disrupting the structural integrity of peritrophic membrane of ...	1,993	2,005	1
6271201	Methods for the selective regulation of placental prostanoids and inhibition of labor using IGF-I	Methods for inhibiting the production of specific vasoconstrictive prostanoids, such as thromboxane and prostaglandin F.sub.2.alpha., through the addition of insulin like growth factor, particularly IGF-I or IGF-II, to human placental cells are disclosed. IGF-I is demonstrated to avoid affecting material and placental...	1,993	2,001	1
6482655	Immunoassay procedure utilizing fluorogenic tracer antigens	Disclosed are fluorescent energy transfer dyes which are capable of moving between a more stacked configuration to exhibit fluorescent quenching and a more spaced configuration to exhibit fluorescence can be conjugated to a peptide epitope for use in the detection of an unknown antibody in bulk solution. The resulting ...	1,993	2,002	1
6690966	Methods of molecular spectroscopy to provide for the diagnosis of tissue	Systems and methods for spectroscopic diagnosis and treatment are employed which utilize molecular spectroscopy to accurately diagnose the condition of tissue. Infrared Raman spectroscopy and infrared attenuated total reflectance measurements are performed utilizing a laser radiation source and a fourier transform spec...	1,993	2,004	1
6737041	Non-ozone depleting vapocoolants	Chemical compositions are provided, for use as topical anesthetics or skin refrigerants. These compositions do not cause the depletion of the stratospheric ozone layer and are non-toxic, non-carcinogenic and less flammable than ethyl chloride. Also these chemical compositions match the skin temperature versus time prof...	1,993	2,004	1
6498147	Suppression of nuclear factor-&kgr;b dependent processes using oligonucleotides	Antisense oligonucleotides which hybridize with nuclear factor-&kgr;B(NF-&kgr;B) mRNA and methods of using these oligonucleotides.	1,993	2,002	1
6235496	Nucleic acid encoding mammalian mu opioid receptor	The invention relates generally to compositions of and methods for obtaining mu opioid receptor polypeptides. The invention relates as well to polynucleotides encoding mu opioid receptor polypeptides, the recombinant vectors carrying those sequences, the recombinant host cells including either the sequences or vectors...	1,993	2,001	1
6197041	Trocar	A pneumatically powered trocar assembly includes a source of compressed gas which releases a metered amount of gas to a chamber. A piston slidably positioned within the chamber is driven forward by the compressed gas introduced therein, and an obturator with a tissue piercing tip are advanced thereby. Optionally, a se...	1,993	2,001	1
6984487	Cystic fibrosis gene	The cystic fibrosis gene and its gene product are described for both the normal and mutant forms. The genetic and protein information is used in developing DNA diagnosis, protein diagnosis, carrier and patient screening, drug and gene therapy, cloning of the gene and manufacture of the protein, and development of cysti...	1,993	2,006	1
6291206	BMP receptor proteins	Novel serine/threonine receptor proteins and BMP receptor proteins are disclosed, as well as DNA molecules encoding said proteins and methods of using the receptor proteins. Further disclosed are truncated BMP receptor proteins and molecules which act as ligands to said BMP receptor proteins.	1,993	2,001	1
6897290	Modified RCA proteins	Analogs of regulators of complement activation (RCA) proteins which have altered specificities and affinities for the targets C3b and/or C4b are described. These analogs are obtained by substituting amino acids which affect the complement inhibitory activities of these proteins, substituting, rearranging or adding SCRs...	1,993	2,005	1
7202333	DNA encoding IgE Receptor α-subunit or fragment thereof	A cDNA sequence encoding the α-subunit of human mast cell IgE surface receptor or an IgE binding fragment thereof.	1,993	2,007	1
6528487	Peptide inhibitors of inflammation mediated by selectins	Peptides derived from three regions of the lectin domain of GMP-140 and the related selectins, ELAM-1 and the lymphocyte homing receptor, have seen found to inhibit neutrophil adhesion to GMP-140. These and additional peptides have been synthesized, having as their core region portions of the 56-60 amino acid sequence ...	1,993	2,003	1
6362175	Porphyrin compounds for imaging tissue oxygen	Methods and compounds for the measurement in vivo of oxygen in living tissue. The compounds preferably comprise a substituted porphyrin which is soluble in aqueous solution which is capable of absorbing an amount of energy and subsequently releasing the energy as phosphorescent light. In preferred embodiments, the porp...	1,993	2,002	1
6218520	DNA sequences encoding human membrane cofactor protein (MCP)	Human membrane cofactor protein, a protein involved in regulation of complement activity, has been purified to homogeneity. The gene encoding this protein has been retrieved and permits deduction of the entire amino acid sequence and the recombinant production of this material. Pharmaceutical compositions in which MCP...	1,993	2,001	1

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PaTRepEval — version v0.4

A SciRepEval-equivalent evaluation suite for patent-trained embedding models. Built on USPTO Open Data Portal granted-patent and pre-grant publication tables, plus external sources (Kogan KPSS, Marx & Fuegi Reliance on Science) for the Pool B / Phase 5 tasks.

Configs

Config	Family	Task type	Metric	Notes
`pool_a`	corpus	—	—	~1.05M utility patents, year × CPC stratified.
`academic_public`	clf	single_label_classification	f1_binary	2 classes
`assignee_patent_match`	prx	retrieval	p@5, p@10, map	queries aggregated by `mean_by_query_id`
`assignee_type`	clf	single_label_classification	f1_macro	3 classes
`cpc_section`	clf	single_label_classification	f1_macro	8 classes
`cpc_subclass`	clf	multi_label_classification	f1_macro	50 classes
`forward_citation`	rgn	regression	kendall_tau	5y window
`grant_abandon`	clf	single_label_classification	f1_binary	2 classes
`grant_year`	rgn	regression	kendall_tau	—
`kogan_value`	rgn	regression	kendall_tau	—
`paper_patent_retrieval`	prx	retrieval	map, ndcg@10	—
`paper_patent_retrieval_hard`	prx	retrieval	map, ndcg@10	—
`papers_cocite`	prx	retrieval	map, ndcg@10	—
`papers_cocite_hard`	prx	retrieval	map, ndcg@10	—
`patent_cite`	prx	retrieval	map, ndcg@10	—
`patent_cocite`	prx	retrieval	map, ndcg@10	—
`patent_paper_citation`	prx	retrieval	map, ndcg@10	—
`patent_paper_citation_hard`	prx	retrieval	map, ndcg@10	—
`ppp_paper`	clf	single_label_classification	f1_binary	2 classes
`ppp_paper_patent`	prx	retrieval	map, ndcg@10	—
`ppp_paper_patent_hard`	prx	retrieval	map, ndcg@10	—
`ppp_patent`	clf	single_label_classification	f1_binary	2 classes
`pqr_paper`	clf	single_label_classification	f1_binary	2 classes
`pqr_paper_patent`	prx	retrieval	map, ndcg@10	—
`pqr_patent`	clf	single_label_classification	f1_binary	2 classes
`pqr_patent_paper`	prx	retrieval	map, ndcg@10	—
`renewal`	clf	single_label_classification	f1_binary	2 classes
`same_initial_assignee`	prx	retrieval	map, ndcg@10	—
`same_initial_assignee_hard`	prx	retrieval	map, ndcg@10	—
`same_inventor`	prx	retrieval	map, ndcg@10	—
`science_uptake`	rgn	regression	kendall_tau	—
`us_foreign`	clf	single_label_classification	f1_binary	2 classes
`vc_backed`	clf	single_label_classification	f1_binary	2 classes

Usage

from datasets import load_dataset

# CLF / RGN: train + test parquets
ds = load_dataset('gebhart/patrepeval', name='cpc_section')
ds['train'][0]  # patent_id, title, abstract, label, year_filed, year_granted

# PRX: corpus + queries + qrels parquets
corpus  = load_dataset('gebhart/patrepeval', name='same_inventor', split='corpus')
queries = load_dataset('gebhart/patrepeval', name='same_inventor', split='queries')
qrels   = load_dataset('gebhart/patrepeval', name='same_inventor', split='qrels')

# Pool A base corpus (read once, share across CLF/RGN at eval time)
pool_a = load_dataset('gebhart/patrepeval', name='pool_a', split='pool_a')

Versioning

This release is v0.4. Use the matching git tag (git checkout <version> after a git clone) when reproducing a paper, since later versions add task configs and may refine splits.

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