tuberculosis_metadata.json

{
  "dataset_name": "tuberculosis",
  "download_urls": {
    "GSE19433": "https://ftp.ncbi.nlm.nih.gov/geo/series/GSE19nnn/GSE19433/matrix/GSE19433_series_matrix.txt.gz",
    "GPL9790_platform": "https://ftp.ncbi.nlm.nih.gov/geo/platforms/GPL9nnn/GPL9790/soft/GPL9790_family.soft.gz",
    "UniProt_H37Rv_proteome": "https://rest.uniprot.org/uniprotkb/stream?query=proteome:UP000001584&fields=accession,reviewed,gene_oln&format=tsv"
  },
  "download_timestamp": "2026-06-30T11:57:18.314708",
  "statistics": {
    "num_samples": 561,
    "num_features": 3814,
    "target_stats": {
      "class_mapping": {
        "NEG": 0,
        "POS": 1
      },
      "num_classes": 2,
      "class_names": [
        "NEG",
        "POS"
      ],
      "samples_per_class": {
        "NEG": 307,
        "POS": 254
      }
    }
  },
  "preprocessing_notes": "GSE19433 M. tuberculosis full-proteome antibody microarray (platform GPL9790, log-transformed raw intensities without normalization). The classification target is the M. tuberculosis culture result (0=NEG, 1=POS); samples with culture \"not applicable\" are dropped. Microarray spot ids (block_row_column) are mapped to M. tuberculosis ORFs (Rv locus tags) via the GPL9790 platform table; array-specific segment/alt spots (\"-s1\", \"-alt\") are collapsed to the base locus tag by averaging. Rv locus tags are mapped to UniProt accessions via the H37Rv reference proteome (UP000001584); spots that do not resolve to a UniProt accession are discarded."
}